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Your search keyword '"van Maren, E. A."' showing total 6 results
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6 results on '"van Maren, E. A."'

1. T2-FLAIR Mismatch: An Imaging Biomarker for Children's MYB/MYBL1-Altered Diffuse Astrocytoma or Angiocentric Glioma.

Author

MS Radiologie, Cancer, Circulatory Health, Brain, Pathologie Pathologen staf, PMC Medisch specialisten, Neurochirurgen, Neurochirurgie, Neurologen, PMC Research, Klinisch Verloskundigen, van Maren, E A, Dankbaar, J W, Wesseling, P, Plasschaert, S, Muhlebner, A, Hoving, E W, Robe, P A, Snijders, T J, Hoogendijk, R, Kranendonk, M E G, Lequin, M H, MS Radiologie, Cancer, Circulatory Health, Brain, Pathologie Pathologen staf, PMC Medisch specialisten, Neurochirurgen, Neurochirurgie, Neurologen, PMC Research, Klinisch Verloskundigen, van Maren, E A, Dankbaar, J W, Wesseling, P, Plasschaert, S, Muhlebner, A, Hoving, E W, Robe, P A, Snijders, T J, Hoogendijk, R, Kranendonk, M E G, and Lequin, M H

Published
2024

3. Resting energy expenditure in children at risk of hypothalamic dysfunction

Author

Van Schaik, J, primary, Burghard, M, additional, Lequin, M H, additional, van Maren, E A, additional, van Dijk, A M, additional, Takken, T, additional, Rehorst-Kleinlugtenbelt, L B, additional, Bakker, B, additional, Meijer, L, additional, Hoving, E W, additional, Fiocco, M, additional, Schouten-van Meeteren, A Y N, additional, Tissing, W J E, additional, and van Santen, H M, additional

Published
2022
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4. Resting energy expenditure in children at risk of hypothalamic dysfunction

Author

MS Radiologie, Activity&Health sectie exercise, Circulatory Health, Cancer, MS Neonatologie, Child Health, Endocrinologie patientenzorg, Huisartsopleiding Ontwikk, Neurochirurgen, PMC Medisch specialisten, Brain, Van Schaik, J., Burghard, M., Lequin, M. H., van Maren, E. A., van Dijk, A. M., Takken, T., Rehorst-Kleinlugtenbelt, L. B., Bakker, B., Meijer, L., Hoving, E. W., Fiocco, M., Schouten-Van Meeteren, A. Y.N., Tissing, W. J.E., van Santen, H. M., MS Radiologie, Activity&Health sectie exercise, Circulatory Health, Cancer, MS Neonatologie, Child Health, Endocrinologie patientenzorg, Huisartsopleiding Ontwikk, Neurochirurgen, PMC Medisch specialisten, Brain, Van Schaik, J., Burghard, M., Lequin, M. H., van Maren, E. A., van Dijk, A. M., Takken, T., Rehorst-Kleinlugtenbelt, L. B., Bakker, B., Meijer, L., Hoving, E. W., Fiocco, M., Schouten-Van Meeteren, A. Y.N., Tissing, W. J.E., and van Santen, H. M.

Published
2022

6. T2-FLAIR Mismatch: An Imaging Biomarker for Children's MYB/MYBL1 -Altered Diffuse Astrocytoma or Angiocentric Glioma.

Author

van Maren EA, Dankbaar JW, Wesseling P, Plasschaert S, Muhlebner A, Hoving EW, Robe PA, Snijders TJ, Hoogendijk R, Kranendonk MEG, and Lequin MH

Subjects
Humans, Child, Male, Female, Adolescent, Child, Preschool, Trans-Activators genetics, Biomarkers, Tumor genetics, Isocitrate Dehydrogenase genetics, Infant, Mutation, Retrospective Studies, Proto-Oncogene Proteins, Astrocytoma diagnostic imaging, Astrocytoma genetics, Astrocytoma pathology, Brain Neoplasms diagnostic imaging, Brain Neoplasms genetics, Brain Neoplasms pathology, Glioma diagnostic imaging, Glioma genetics, Glioma pathology, Magnetic Resonance Imaging methods, Proto-Oncogene Proteins c-myb genetics
Abstract

Background and Purpose: T2-FLAIR mismatch is a highly specific imaging biomarker of IDH -mutant diffuse astrocytoma in adults. It has however also been described in MYB/MYBL1 -altered low grade tumors. Our aim was to assess the diagnostic power of the T2-FLAIR mismatch in IDH -mutant astrocytoma and MYB/MYBL1 -altered low-grade tumors in children and correlate this mismatch with histology., Materials and Methods: We evaluated MR imaging examinations of all pediatric patients, performed at the Princess Máxima Center for Pediatric Oncology and the University Medical Center Utrecht between January 2012 and January 2023, with the histomolecular diagnosis of IDH -mutant astrocytoma, diffuse astrocytoma MYB/MYBL1 -altered, or angiocentric glioma, and the presence of T2-FLAIR mismatch was assessed. Histologically, the presence of microcysts in the tumor (a phenomenon suggested to be correlated with T2-FLAIR mismatch in IDH -mutant astrocytomas in adults) was evaluated., Results: Nineteen pediatric patients were diagnosed with either IDH -mutant astrocytoma ( n  = 8) or MYB/MYBL1 -altered tumor ( n  = 11: diffuse astrocytoma , MYB- or MYBL1 -altered n  = 8; or angiocentric glioma n  = 3). T2-FLAIR mismatch was present in 11 patients, 3 (38%) in the IDH -mutant group and 8 (73%) in the MYB/MYBL1 group. No correlation was found between T2-FLAIR mismatch and the presence of microcysts or an enlarged intercellular space in either IDH -mutant astrocytoma ( P  = .38 and P  = .56, respectively) or MYB/MYBL1 -altered tumors ( P  = .36 and P  = .90, respectively)., Conclusions: In our pediatric population, T2-FLAIR mismatch was more often found in MYB/MYBL1 -altered tumors than in IDH -mutant astrocytomas. In contrast to what has been reported for IDH -mutant astrocytomas in adults, no correlation was found with microcystic changes in the tumor tissue. This finding challenges the hypothesis that such microcystic changes and/or enlarged intercellular spaces in the tissue of these tumors are an important part of explaining the occurrence of the T2-FLAIR mismatch., (© 2024 by American Journal of Neuroradiology.)

Published
2024
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