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3. Prevalence and 3-month follow-up of cerebrovascular MRI markers in hospitalized COVID-19 patients: the CORONIS study

Author

Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Neurologen, Stroke, van Lith, Theresa J., Sluis, Wouter M., Wijers, Naomi T., Meijer, Frederick J.A., Ulzen, Karin Kamphuis van, de Bresser, Jeroen, Dankbaar, Jan Willem, de Mast, Quirijn, Klok, Frederikus A., Cannegieter, Suzanne C., Wermer, Marieke J.H., Huisman, Menno V., Tuladhar, Anil M., van der Worp, H. Bart, de Leeuw, Frank Erik, Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Neurologen, Stroke, van Lith, Theresa J., Sluis, Wouter M., Wijers, Naomi T., Meijer, Frederick J.A., Ulzen, Karin Kamphuis van, de Bresser, Jeroen, Dankbaar, Jan Willem, de Mast, Quirijn, Klok, Frederikus A., Cannegieter, Suzanne C., Wermer, Marieke J.H., Huisman, Menno V., Tuladhar, Anil M., van der Worp, H. Bart, and de Leeuw, Frank Erik

Published
2024

4. White matter integrity in hospitalized COVID-19 patients is not associated with short- and long-term clinical outcomes

Author

Opleiding Neurologie, van Lith, Theresa J, Li, Hao, van der Wijk, Marte W, Wijers, Naomi T, Sluis, Wouter M, Wermer, Marieke J H, de Leeuw, Frank-Erik, Meijer, Frederick J A, Tuladhar, Anil M, Opleiding Neurologie, van Lith, Theresa J, Li, Hao, van der Wijk, Marte W, Wijers, Naomi T, Sluis, Wouter M, Wermer, Marieke J H, de Leeuw, Frank-Erik, Meijer, Frederick J A, and Tuladhar, Anil M

Published
2024

5. White matter integrity in hospitalized COVID-19 patients is not associated with short- and long-term clinical outcomes.

Author

van Lith, Theresa J., Hao Li, van der Wijk, Marte W., Wijers, Naomi T., Sluis, Wouter M., Wermer, Marieke J. H., de Leeuw, Frank-Erik, Meijer, Frederick J. A., and Tuladhar, Anil M.

Subjects
POST-acute COVID-19 syndrome, COVID-19, DIFFUSION tensor imaging, PATIENT experience, VISUAL analog scale
Abstract

Objectives: SARS-CoV-2 infection is associated with a decline in functional outcomes; many patients experience persistent symptoms, while the underlying pathophysiology remains unclear. This study investigated white matter (WM) integrity on brain MRI in hospitalized COVID-19 patients and its associations with clinical outcomes, including long COVID. Materials and methods: We included hospitalized COVID-19 patients and controls from CORONavirus and Ischemic Stroke (CORONIS), an observational cohort study, who underwent MRI-DWI imaging at baseline shortly after discharge (<3 months after positive PCR) and 3 months after baseline scanning. We assessed WM integrity using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) and performed comparisons between groups and within patients. Clinical assessment was conducted at 3 and 12 months with functional outcomes such as modified Rankin Scale (mRS), Post-COVID-19 Functional Status scale (PCFS), Visual Analogue Scale (VAS), and long COVID, cognitive assessment was conducted by the Modified Telephone Interview for Cognitive Status (TICS-M), and the Hospital Anxiety and Depression Scale (HADS) was used to assess mood disorder. Associations between WM integrity and clinical outcomes were evaluated using logistic regression and linear regression. Results: A total of 49 patients (mean age 59.5 years) showed higher overall peak width of skeletonized mean diffusivity (PSMD) (p = 0.030) and lower neurite density index (NDI) in several WM regions compared with 25 controls at the baseline (p < 0.05; FWE-corrected) but did not remain statistically significant after adjusting for WM hyperintensities. Orientation dispersion index (ODI) increased after 3-month follow-up in several WM regions within patients (p < 0.05), which remained significant after correction for changes in WMH volume. Patients exhibited worse clinical outcomes compared with controls. Low NDI at baseline was associated with worse performance on the Post-COVID-19 Functional Status scale after 12 months (p = 0.018). Conclusion: After adjusting for WMH, hospitalized COVID-19 patients no longer exhibited lower WM integrity compared with controls. WM integrity was generally not associated with clinical assessments as measured shortly after discharge, suggesting that factors other than underlying WM integrity play a role in worse clinical outcomes or long COVID. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study: A multicentre prospective cohort study

Author

Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Neurologen, Stroke, van Lith, Theresa J, Sluis, Wouter M, Wijers, Naomi T, Meijer, Frederick Ja, Kamphuis-van Ulzen, Karin, de Bresser, Jeroen, Dankbaar, Jan Willem, van den Heuvel, Frederik Ma, Antoni, M Louisa, Mulders-Manders, Catharina M, de Mast, Quirijn, van de Veerdonk, Frank L, Klok, Frederikus A, Tuladhar, Anil M, Cannegieter, Suzanne C, Wermer, Marieke Jh, van der Worp, H Bart, Huisman, Menno V, de Leeuw, Frank-Erik, Opleiding Neurologie, MS Radiologie, Brain, Cancer, Circulatory Health, Neurologen, Stroke, van Lith, Theresa J, Sluis, Wouter M, Wijers, Naomi T, Meijer, Frederick Ja, Kamphuis-van Ulzen, Karin, de Bresser, Jeroen, Dankbaar, Jan Willem, van den Heuvel, Frederik Ma, Antoni, M Louisa, Mulders-Manders, Catharina M, de Mast, Quirijn, van de Veerdonk, Frank L, Klok, Frederikus A, Tuladhar, Anil M, Cannegieter, Suzanne C, Wermer, Marieke Jh, van der Worp, H Bart, Huisman, Menno V, and de Leeuw, Frank-Erik

Published
2022

10. Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients – study rationale and protocol of the CORONIS study: A multicentre prospective cohort study

Author

van Lith, Theresa J, primary, Sluis, Wouter M, additional, Wijers, Naomi T, additional, Meijer, Frederick JA, additional, Kamphuis-van Ulzen, Karin, additional, de Bresser, Jeroen, additional, Dankbaar, Jan Willem, additional, van den Heuvel, Frederik MA, additional, Antoni, M Louisa, additional, Mulders-Manders, Catharina M, additional, de Mast, Quirijn, additional, van de Veerdonk, Frank L, additional, Klok, Frederikus A, additional, Tuladhar, Anil M, additional, Cannegieter, Suzanne C, additional, Wermer, Marieke JH, additional, van der Worp, H Bart, additional, Huisman, Menno V, additional, and de Leeuw, Frank-Erik, additional

Published
2022
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