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29 results on '"van Lindert, A. S.R."'

6. Open communication between patients and relatives about illness & death in advanced cancer—results of the eQuiPe Study

Author

Longziekten, Cancer, Infection & Immunity, Haaksman, Michelle, Ham, Laurien, Brom, Linda, Baars, Arnold, van Basten, Jean Paul, van den Borne, Ben E.E.M., Hendriks, Mathijs P., de Jong, Wouter K., van Laarhoven, Hanneke W.M., van Lindert, Anne S.R., Mandigers, Caroline M.P.W., van der Padt-Pruijsten, Annemieke, Smilde, Tineke J., van Zuylen, Lia C., van Vliet, Liesbeth M., Raijmakers, Natasja J.H., Longziekten, Cancer, Infection & Immunity, Haaksman, Michelle, Ham, Laurien, Brom, Linda, Baars, Arnold, van Basten, Jean Paul, van den Borne, Ben E.E.M., Hendriks, Mathijs P., de Jong, Wouter K., van Laarhoven, Hanneke W.M., van Lindert, Anne S.R., Mandigers, Caroline M.P.W., van der Padt-Pruijsten, Annemieke, Smilde, Tineke J., van Zuylen, Lia C., van Vliet, Liesbeth M., and Raijmakers, Natasja J.H.

Published
2024

7. Hematologic malignancies following immune checkpoint inhibition for solid tumors

Author

MS Medische Oncologie, CTI, Cancer, MS Hematologie, Infection & Immunity, Pathologie Pathologen staf, CDL Cluster Speciële Diagnostiek, Longziekten, CDL Patiëntenzorg MI, CTI Research, van Eijs, Mick J.M., van der Wagen, Lotte E., Mous, Rogier, Leguit, Roos J., van de Corput, Lisette, van Lindert, Anne S.R., Suelmann, Britt B.M., Kamphuis, Anna M., Nierkens, Stefan, Suijkerbuijk, Karijn P.M., MS Medische Oncologie, CTI, Cancer, MS Hematologie, Infection & Immunity, Pathologie Pathologen staf, CDL Cluster Speciële Diagnostiek, Longziekten, CDL Patiëntenzorg MI, CTI Research, van Eijs, Mick J.M., van der Wagen, Lotte E., Mous, Rogier, Leguit, Roos J., van de Corput, Lisette, van Lindert, Anne S.R., Suelmann, Britt B.M., Kamphuis, Anna M., Nierkens, Stefan, and Suijkerbuijk, Karijn P.M.

Published
2023

10. The association between skeletal muscle measures and chemotherapy-induced toxicity in non-small cell lung cancer patients

Author

Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Researchgr. Systems Radiology, Circulatory Health, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Apotheek O&O&O, Brain, Child Health, MS Hoofd-Hals Chirurgische Oncologie, Apotheek Klinische Farmacie, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J.M., van Haarlem, Simone W.A., van der Meer, Femke, van Lindert, Anne S.R., ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A., Devriese, Lot A., Huitema, Alwin D.R., Egberts, Toine C.G., de Bree, Remco, Deneer, Vera H.M., Apotheek Onderzoek, Cancer, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, Researchgr. Systems Radiology, Circulatory Health, Regenerative Medicine and Stem Cells, MS Medische Oncologie, Apotheek O&O&O, Brain, Child Health, MS Hoofd-Hals Chirurgische Oncologie, Apotheek Klinische Farmacie, de Jong, Corine, Chargi, Najiba, Herder, Gerarda J.M., van Haarlem, Simone W.A., van der Meer, Femke, van Lindert, Anne S.R., ten Heuvel, Alexandra, Brouwer, Jan, de Jong, Pim A., Devriese, Lot A., Huitema, Alwin D.R., Egberts, Toine C.G., de Bree, Remco, and Deneer, Vera H.M.

Published
2022

11. The overall survival impact of prophylactic cranial irradiation in limited-stage small-cell lung cancer: A systematic review and meta-analysis

Author

Verpleegkundig Specialisten Longziekten, Longziekten, Infection & Immunity, Cancer, Arts-assistenten Radiotherapie, MS Radiotherapie, Tomassen, Mathijs L., Pomp, Jacquelien, van der Stap, Janneke, van Lindert, Anne S.R., Peters, Max, Belderbos, José S.A., De Ruysscher, Dirk K.M., Lin, Steven H., Verhoeff, Joost J.C., van Rossum, Peter S.N., Verpleegkundig Specialisten Longziekten, Longziekten, Infection & Immunity, Cancer, Arts-assistenten Radiotherapie, MS Radiotherapie, Tomassen, Mathijs L., Pomp, Jacquelien, van der Stap, Janneke, van Lindert, Anne S.R., Peters, Max, Belderbos, José S.A., De Ruysscher, Dirk K.M., Lin, Steven H., Verhoeff, Joost J.C., and van Rossum, Peter S.N.

Published
2022

12. Life-prolonging treatment restrictions and outcomes in patients with cancer and COVID-19: an update from the Dutch Oncology COVID-19 Consortium

Author

MS Medische Oncologie, Infection & Immunity, Cancer, Longziekten, de Joode, Karlijn, Tol, Jolien, Hamberg, Paul, Cloos, Marissa, Kastelijn, Elisabeth A., Borgers, Jessica S.W., Nuij, Veerle J.A.A., Klaver, Yarne, Herder, Gerarda J.M., Mutsaers, Pim G.N.J., Dumoulin, Daphne W., Oomen-de Hoop, Esther, van Diemen, Nico G.J., Libourel, Eduard J., Geraedts, Erica J., Bootsma, Gerben P., van der Leest, Cor H., Peerdeman, Anne L., Herbschleb, Karin H., Visser, Otto J., Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., de Vries, Elisabeth G.E., Hendriks, Lizza E.L., Beerepoot, Laurens V., Westgeest, Hans M., van den Berkmortel, Franchette W.P.J., Haanen, John B.A.G., Dingemans, Anne Marie C., van der Veldt, Astrid A.M., Becker-Commissaris, A., Terheggen, F., van den Borne, B. E.E.M., van Warmerdam, L. J.C., van Leeuwen, L., van der Meer, F. S., Tiemessen, M. A., van Diepen, D. M., Strobbe, L., Koekkoek, J. A.F., Brocken, P., Drooger, J. C., de Groot, J. W.B., Aarts, M. J.B., Cirkel, G. A., Claessens, N. J.M., Jalving, M., Suijkerbuijk, K. P.M., van Lindert, A. S.R., Bakker, S. D., MS Medische Oncologie, Infection & Immunity, Cancer, Longziekten, de Joode, Karlijn, Tol, Jolien, Hamberg, Paul, Cloos, Marissa, Kastelijn, Elisabeth A., Borgers, Jessica S.W., Nuij, Veerle J.A.A., Klaver, Yarne, Herder, Gerarda J.M., Mutsaers, Pim G.N.J., Dumoulin, Daphne W., Oomen-de Hoop, Esther, van Diemen, Nico G.J., Libourel, Eduard J., Geraedts, Erica J., Bootsma, Gerben P., van der Leest, Cor H., Peerdeman, Anne L., Herbschleb, Karin H., Visser, Otto J., Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., de Vries, Elisabeth G.E., Hendriks, Lizza E.L., Beerepoot, Laurens V., Westgeest, Hans M., van den Berkmortel, Franchette W.P.J., Haanen, John B.A.G., Dingemans, Anne Marie C., van der Veldt, Astrid A.M., Becker-Commissaris, A., Terheggen, F., van den Borne, B. E.E.M., van Warmerdam, L. J.C., van Leeuwen, L., van der Meer, F. S., Tiemessen, M. A., van Diepen, D. M., Strobbe, L., Koekkoek, J. A.F., Brocken, P., Drooger, J. C., de Groot, J. W.B., Aarts, M. J.B., Cirkel, G. A., Claessens, N. J.M., Jalving, M., Suijkerbuijk, K. P.M., van Lindert, A. S.R., and Bakker, S. D.

Published
2022

13. Non-Small-Cell Lung Cancer Patients with a High Predicted Risk of Irradical Resection: Can Chemoradiotherapy Offer Similar Survival?

Author

Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, Longziekten, Infection & Immunity, CTC, van Joolingen, W. Hugo, Rasing, Marnix J.A., Peters, Max, van Lindert, Anne S.R., de Heer, Linda M., Aarts, Mieke J., Verhoeff, Joost J.C., van Rossum, Peter S.N., Onderzoek Radiotherapie, Cancer, MS Radiotherapie, Arts-assistenten Radiotherapie, Longziekten, Infection & Immunity, CTC, van Joolingen, W. Hugo, Rasing, Marnix J.A., Peters, Max, van Lindert, Anne S.R., de Heer, Linda M., Aarts, Mieke J., Verhoeff, Joost J.C., and van Rossum, Peter S.N.

Published
2022

14. The association between skeletal muscle measures and chemotherapy‐induced toxicity in non‐small cell lung cancer patients

Author

de Jong, Corine, primary, Chargi, Najiba, additional, Herder, Gerarda J.M., additional, van Haarlem, Simone W.A., additional, van der Meer, Femke, additional, van Lindert, Anne S.R., additional, ten Heuvel, Alexandra, additional, Brouwer, Jan, additional, de Jong, Pim A., additional, Devriese, Lot A., additional, Huitema, Alwin D.R., additional, Egberts, Toine C.G., additional, de Bree, Remco, additional, and Deneer, Vera H.M., additional

Published
2022
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15. Individual treatment effect estimation in the presence of unobserved confounding using proxies: a cohort study in stage III non-small cell lung cancer

Author

van Amsterdam, Wouter A.C., primary, Verhoeff, Joost J.C., additional, Harlianto, Netanja I, additional, Bartholomeus, Gijs A, additional, Manas Puli, Aahlad, additional, de Jong, Pim A, additional, Leiner, Tim, additional, van Lindert, Anne S.R., additional, Eijkemans, Marinus J.C., additional, and Ranganath, Rajesh, additional

Published
2021
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17. Perceptions of involvement in advance care planning and emotional functioning in patients with advanced cancer

Author

Kroon, Lente L., van Roij, Janneke, Korfage, Ida J., Reyners, An K.L., van den Beuken-van Everdingen, Marieke H.J., den Boer, Marien O., Creemers, Geert Jan, de Graeff, Alexander, Hendiks, Mathijs P., Hunting, Jarmo C.B., de Jong, Wouter K., Kuip, Evelien, van Laarhoven, Hanneke W.M., van Leeuwen, Lobke, van Lindert, Anne S.R., Mandigers, Caroline M.P.W., Nieboer, Peter, van der Padt-Pruijsten, Annemieke, Smilde, Tineke J., Sommeijer, Dirkje W., Thijs, Martine F., Tiemessen, Marian A., Vos, Allert H., Vreugdenhil, Art, Werner, Philo T., van Zuylen, Lia, van de Poll-Franse, Lonneke V., Raijmakers, Natasja J.H., Kroon, Lente L., van Roij, Janneke, Korfage, Ida J., Reyners, An K.L., van den Beuken-van Everdingen, Marieke H.J., den Boer, Marien O., Creemers, Geert Jan, de Graeff, Alexander, Hendiks, Mathijs P., Hunting, Jarmo C.B., de Jong, Wouter K., Kuip, Evelien, van Laarhoven, Hanneke W.M., van Leeuwen, Lobke, van Lindert, Anne S.R., Mandigers, Caroline M.P.W., Nieboer, Peter, van der Padt-Pruijsten, Annemieke, Smilde, Tineke J., Sommeijer, Dirkje W., Thijs, Martine F., Tiemessen, Marian A., Vos, Allert H., Vreugdenhil, Art, Werner, Philo T., van Zuylen, Lia, van de Poll-Franse, Lonneke V., and Raijmakers, Natasja J.H.

Abstract

Purpose: Advance Care Planning (ACP) is positively associated with the quality of care, but its impact on emotional functioning is ambiguous. This study investigated the association between perceptions of ACP involvement and emotional functioning in patients with advanced cancer. Methods: This study analyzed baseline data of 1,001 patients of the eQuiPe study, a prospective, longitudinal, multicenter, observational study on quality of care and quality of life in patients with advanced cancer in the Netherlands. Patients with metastatic solid cancer were asked to participate between November 2017 and January 2020. Patients’ perceptions of ACP involvement were measured by three self-administered statements. Emotional functioning was measured by the EORTC-QLQ-C30. A linear multivariable regression analysis was performed while taking gender, age, migrant background, education, marital status, and symptom burden into account. Results: The majority of patients (87%) reported that they were as much involved as they wanted to be in decisions about their future medical treatment and care. Most patients felt that their relatives (81%) and physicians (75%) were familiar with their preferences for future medical treatment and care. A positive association was found between patients’ perceptions of ACP involvement and their emotional functioning (b=0.162, p<0.001, 95%CI[0.095;0.229]) while controlling for relevant confounders. Conclusions: Perceptions of involvement in ACP are positively associated with emotional functioning in patients with advanced cancer. Future studies are needed to further investigate the effect of ACP on emotional functioning. Trial registration number: NTR6584 Date of registration: 30 June 2017 Implications for Cancer Survivors: Patients’ emotional functioning might improve from routine discussions regarding goals of future care. Therefore, integration of ACP into palliative might be promising.

Published
2021

18. Clinical utility of plasma-based comprehensive molecular profiling in advanced non-small-cell lung cancer

Author

Longziekten, Infection & Immunity, Schouten, Robert D., Vessies, Daan C.L., Bosch, Linda J.W., Barlo, Nicole P., van Lindert, Anne S.R., Cillessen, Saskia A.G.M., van den Broek, Daan, van den Heuvel, Michel M., Monkhorst, Kim, Longziekten, Infection & Immunity, Schouten, Robert D., Vessies, Daan C.L., Bosch, Linda J.W., Barlo, Nicole P., van Lindert, Anne S.R., Cillessen, Saskia A.G.M., van den Broek, Daan, van den Heuvel, Michel M., and Monkhorst, Kim

Published
2021

19. Considerable interlaboratory variation in PD-L1 positivity in a nationwide cohort of non-small cell lung cancer patients

Author

Pathologie Opleiding, Cancer, Pathologie Groep Moelans, Longziekten, Infection & Immunity, Pathologie Pathologen staf, Koomen, Bregje M., Voorham, Quirinus J.M., Epskamp-Kuijpers, Chantal C.H.J., van Dooijeweert, Carmen, van Lindert, Anne S.R., Deckers, Ivette A.G., Willems, Stefan M., Pathologie Opleiding, Cancer, Pathologie Groep Moelans, Longziekten, Infection & Immunity, Pathologie Pathologen staf, Koomen, Bregje M., Voorham, Quirinus J.M., Epskamp-Kuijpers, Chantal C.H.J., van Dooijeweert, Carmen, van Lindert, Anne S.R., Deckers, Ivette A.G., and Willems, Stefan M.

Published
2021

21. Impact of Lung Cancer Treatment on Cognitive Functioning

Author

Unit Opleiding Geriatrie, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, van de Kamp, Henrieke J., Molder, Marthe te, Schulkes, Karlijn J.G., Stellingwerf, Margriet, van Elden, Leontine J.R., van Lindert, Anne S.R., Hamaker, Marije E., Unit Opleiding Geriatrie, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, van de Kamp, Henrieke J., Molder, Marthe te, Schulkes, Karlijn J.G., Stellingwerf, Margriet, van Elden, Leontine J.R., van Lindert, Anne S.R., and Hamaker, Marije E.

Published
2020

22. Multicenter Comparison of Molecular Tumor Boards in The Netherlands:Definition, Composition, Methods, and Targeted Therapy Recommendations

Author

Koopman, Bart, Groen, Harry J.M., Ligtenberg, Marjolijn J.L., Grünberg, Katrien, Monkhorst, Kim, de Langen, Adrianus J., Boelens, Mirjam C., Paats, Marthe S., von der Thüsen, Jan H., Dinjens, Winand N.M., Solleveld, Nienke, van Wezel, Tom, Gelderblom, Hans, Hendriks, Lizza E., Speel, Ernst Jan M., Theunissen, Tom E., Kroeze, Leonie I., Mehra, Niven, Piet, Berber, van der Wekken, Anthonie J., ter Elst, Arja, Timens, Wim, Willems, Stefan M., Meijers, Ruud W.J., de Leng, Wendy W.J., van Lindert, Anne S.R., Radonic, Teodora, Hashemi, Sayed M.S., Heideman, Daniëlle A.M., Schuuring, Ed, van Kempen, Léon C., Koopman, Bart, Groen, Harry J.M., Ligtenberg, Marjolijn J.L., Grünberg, Katrien, Monkhorst, Kim, de Langen, Adrianus J., Boelens, Mirjam C., Paats, Marthe S., von der Thüsen, Jan H., Dinjens, Winand N.M., Solleveld, Nienke, van Wezel, Tom, Gelderblom, Hans, Hendriks, Lizza E., Speel, Ernst Jan M., Theunissen, Tom E., Kroeze, Leonie I., Mehra, Niven, Piet, Berber, van der Wekken, Anthonie J., ter Elst, Arja, Timens, Wim, Willems, Stefan M., Meijers, Ruud W.J., de Leng, Wendy W.J., van Lindert, Anne S.R., Radonic, Teodora, Hashemi, Sayed M.S., Heideman, Daniëlle A.M., Schuuring, Ed, and van Kempen, Léon C.

Abstract

Background: Molecular tumor boards (MTBs) provide rational, genomics-driven, patient-tailored treatment recommendations. Worldwide, MTBs differ in terms of scope, composition, methods, and recommendations. This study aimed to assess differences in methods and agreement in treatment recommendations among MTBs from tertiary cancer referral centers in The Netherlands. Materials and Methods: MTBs from all tertiary cancer referral centers in The Netherlands were invited to participate. A survey assessing scope, value, logistics, composition, decision-making method, reporting, and registration of the MTBs was completed through on-site interviews with members from each MTB. Targeted therapy recommendations were compared using 10 anonymized cases. Participating MTBs were asked to provide a treatment recommendation in accordance with their own methods. Agreement was based on which molecular alteration(s) was considered actionable with the next line of targeted therapy. Results: Interviews with 24 members of eight MTBs revealed that all participating MTBs focused on rare or complex mutational cancer profiles, operated independently of cancer type–specific multidisciplinary teams, and consisted of at least (thoracic and/or medical) oncologists, pathologists, and clinical scientists in molecular pathology. Differences were the types of cancer discussed and the methods used to achieve a recommendation. Nevertheless, agreement among MTB recommendations, based on identified actionable molecular alteration(s), was high for the 10 evaluated cases (86%). Conclusion: MTBs associated with tertiary cancer referral centers in The Netherlands are similar in setup and reach a high agreement in recommendations for rare or complex mutational cancer profiles. We propose a “Dutch MTB model” for an optimal, collaborative, and nationally aligned MTB workflow. Implications for Practice: Interpretation of genomic analyses for optimal choice of target therapy for patients with cancer is becoming

Published
2020

23. Dutch Oncology COVID-19 consortium: Outcome of COVID-19 in patients with cancer in a nationwide cohort study

Author

MS Medische Oncologie, Cancer, Infection & Immunity, Longziekten, de Joode, Karlijn, Dumoulin, Daphne W., Tol, Jolien, Westgeest, Hans M., Beerepoot, Laurens V., van den Berkmortel, Franchette W.P.J., Mutsaers, Pim G.N.J., van Diemen, Nico G.J., Visser, Otto J., Oomen-de Hoop, Esther, Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., Hendriks, Lizza E.L., Haanen, John B.A.G., de Vries, Elisabeth G.E., Dingemans, Anne Marie C., van der Veldt, Astrid A.M., van Loenhout, C. J., van der Leest, C. H., Becker-Commissaris, A., Borgers, J. S.W., Terhegggen, F., van den Borne, B. E.E.M., van Warmerdam, L. J.C., van Leeuwen, L., van der Meer, F. S., Tiemessen, M. A., van Diepen, D. M., Klaver, Y., Hamberg, A. P., Libourel, E. J., Strobbe, L., Cloos, M., Geraedts, E. J., Drooger, J. C., Heller, R., de Groot, J. W.B., Stigt, J. A., Nuij, V. J.A.A., Pitz, C. C.M., Slingerland, M., Borm, F. J., Haberkorn, B. C.M., Westeinde, S. C.van t., Aarts, M. J.B., van Putten, J. W.G., Youssef, M., Cirkel, G. A., Herder, G. J.M., van Rooijen, C. R., Citgez, E., Barlo, N. P., Scholtes, B. M.J., Koornstra, R. H.T., Claessens, N. J.M., Faber, L. M., Rikers, C. H., van de Wetering, R. A.W., Veurink, G. L., Bouter, B. W., Houtenbos, I., Bard, M. P.L., Herbschleb, K. H., Kastelijn, E. A., Brocken, P., Douma, G., Jalving, M., Hiltermann, T. J.N., Schuurbiers-Siebers, O. C.J., Suijkerbuijk, K. P.M., van Lindert, A. S.R., van de Wouw, A. J., van den Boogaart, V. E.M., Bakker, S. D., Looysen, E., Peerdeman, A. L., de Jong, W. K., Siemerink, E. J.M., Staal, A. J., Franken, B., van Geffen, W. H., Bootsma, G. P., MS Medische Oncologie, Cancer, Infection & Immunity, Longziekten, de Joode, Karlijn, Dumoulin, Daphne W., Tol, Jolien, Westgeest, Hans M., Beerepoot, Laurens V., van den Berkmortel, Franchette W.P.J., Mutsaers, Pim G.N.J., van Diemen, Nico G.J., Visser, Otto J., Oomen-de Hoop, Esther, Bloemendal, Haiko J., van Laarhoven, Hanneke W.M., Hendriks, Lizza E.L., Haanen, John B.A.G., de Vries, Elisabeth G.E., Dingemans, Anne Marie C., van der Veldt, Astrid A.M., van Loenhout, C. J., van der Leest, C. H., Becker-Commissaris, A., Borgers, J. S.W., Terhegggen, F., van den Borne, B. E.E.M., van Warmerdam, L. J.C., van Leeuwen, L., van der Meer, F. S., Tiemessen, M. A., van Diepen, D. M., Klaver, Y., Hamberg, A. P., Libourel, E. J., Strobbe, L., Cloos, M., Geraedts, E. J., Drooger, J. C., Heller, R., de Groot, J. W.B., Stigt, J. A., Nuij, V. J.A.A., Pitz, C. C.M., Slingerland, M., Borm, F. J., Haberkorn, B. C.M., Westeinde, S. C.van t., Aarts, M. J.B., van Putten, J. W.G., Youssef, M., Cirkel, G. A., Herder, G. J.M., van Rooijen, C. R., Citgez, E., Barlo, N. P., Scholtes, B. M.J., Koornstra, R. H.T., Claessens, N. J.M., Faber, L. M., Rikers, C. H., van de Wetering, R. A.W., Veurink, G. L., Bouter, B. W., Houtenbos, I., Bard, M. P.L., Herbschleb, K. H., Kastelijn, E. A., Brocken, P., Douma, G., Jalving, M., Hiltermann, T. J.N., Schuurbiers-Siebers, O. C.J., Suijkerbuijk, K. P.M., van Lindert, A. S.R., van de Wouw, A. J., van den Boogaart, V. E.M., Bakker, S. D., Looysen, E., Peerdeman, A. L., de Jong, W. K., Siemerink, E. J.M., Staal, A. J., Franken, B., van Geffen, W. H., and Bootsma, G. P.

Published
2020

24. Landelijke variatie in moleculaire diagnostiek bij gemetastaseerde longkanker

Author

Kuijpers, Chantal C.H.J., van den Heuvel, Michel M., Overbeek, Lucy I.H., van Slooten, H. J., van Lindert, Anne S.R., Damhuis, Ronald A.M., and Willems, Stefan M.

Subjects
Medicine(all), hemic and lymphatic diseases
Abstract

OBJECTIVE: The objective of this study is to determine at a national level whether patients with metastatic non-small cell lung cancer (NSCLC) are adequately tested for EGFR mutations and ALK rearrangement, because targeted therapy is tailored to the results of molecular diagnostics. DESIGN: Retrospective cohort study. METHOD: Data from all patients with metastatic non-squamous NSCLC diagnosed in 2013 or 2015 were identified from the Netherlands Cancer Registry, and coupled with data from the Netherlands national pathology registry (PALGA). Using information extracted from PALGA we determined what percentage of the tumours were tested for EGFR or KRAS mutations and ALK rearrangement, identified the variables that were associated with the performance of molecular diagnostics and investigated the differences between 48 laboratories. RESULTS: A total of 6,619 patients were included (2013: n = 3,195; 2015: n = 3,424). In 2013, EGFR or KRAS testing was performed on 73.1% of the tumours (variation between laboratories 30.6-91.7%); in 2015 this was 78.9% (variation 40.0-91.0%). In 2013 49.5% of the tumours without EGFR or KRAS mutations underwent ALK testing (variation between laboratories 6.3-100%) and in 2015 ALK testing was performed on 77.4% (32.5-100%). In 2015, 6 and 7 laboratories tested significantly fewer EGFR and ALK tests, respectively, than the national average. CONCLUSION: In 2013, molecular testing for EGFR and KRAS mutations and, in particular, for ALK rearrangement was suboptimal. EGFR and ALK testing was performed significantly more often in 2015. Despite this increase, there is room for improvement in a number of laboratories and hospitals, considering that some patients were possibly wrongly not eligible for targeted therapy.

Published
2018

26. Landelijke variatie in moleculaire diagnostiek bij gemetastaseerde longkanker

Author

Kuijpers, Chantal C.H.J., Van Den Heuvel, Michel M., Overbeek, Lucy I.H., Van Slooten, Henk Jan, Van Lindert, Anne S.R., Damhuis, Ronald A.M., Willems, Stefan M., Kuijpers, Chantal C.H.J., Van Den Heuvel, Michel M., Overbeek, Lucy I.H., Van Slooten, Henk Jan, Van Lindert, Anne S.R., Damhuis, Ronald A.M., and Willems, Stefan M.

Published
2019

27. Landelijke variatie in moleculaire diagnostiek bij gemetastaseerde longkanker

Author

Pathologie Groep Moelans, Cancer, Onderzoeksgroep 6, Longziekten, Infection & Immunity, Pathologie Pathologen staf, Kuijpers, Chantal C.H.J., Van Den Heuvel, Michel M., Overbeek, Lucy I.H., Van Slooten, Henk Jan, Van Lindert, Anne S.R., Damhuis, Ronald A.M., Willems, Stefan M., Pathologie Groep Moelans, Cancer, Onderzoeksgroep 6, Longziekten, Infection & Immunity, Pathologie Pathologen staf, Kuijpers, Chantal C.H.J., Van Den Heuvel, Michel M., Overbeek, Lucy I.H., Van Slooten, Henk Jan, Van Lindert, Anne S.R., Damhuis, Ronald A.M., and Willems, Stefan M.

Published
2019

29. Association of molecular status and metastatic organs at diagnosis in patients with stage IV non-squamous non-small cell lung cancer

Author

Pathologie Groep Moelans, Cancer, MS Verloskunde, Other research (not in main researchprogram), Longziekten, Infection & Immunity, Onderzoeksgroep 6, Pathologie Pathologen staf, Kuijpers, C. C.H.J., Hendriks, L. E.L., Derks, J. L., Dingemans, A. M.C., van Lindert, A. S.R., van den Heuvel, M. M., Damhuis, R. A., Willems, S. M., Pathologie Groep Moelans, Cancer, MS Verloskunde, Other research (not in main researchprogram), Longziekten, Infection & Immunity, Onderzoeksgroep 6, Pathologie Pathologen staf, Kuijpers, C. C.H.J., Hendriks, L. E.L., Derks, J. L., Dingemans, A. M.C., van Lindert, A. S.R., van den Heuvel, M. M., Damhuis, R. A., and Willems, S. M.

Published
2018

Catalog

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