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Your search keyword '"van Kroonenburgh, M.J.P.G."' showing total 13 results
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13 results on '"van Kroonenburgh, M.J.P.G."'

3. MR imaging, Single-photon emission CT and Neurocognitive performance after mild traumatic brain injury

Author

Hofman, P.A.M., Stapert, S.Z., van Kroonenburgh, M.J.P.G., Jolles, J., de Kruijk, J.R., Wilmink, J.T., RS: FPN NPPP I, Beeldvorming, Neuropsychology & Psychopharmacology, and MUMC+: DA BV Medisch Specialisten Nucleaire Geneesk (9)

Abstract

BACKGROUND AND PURPOSE: Mild traumatic brain injury (mTBI) (Glasgow Coma Scale = 14-15) is a common neurologic disorder and a common cause of neurocognitive deficits in the young population. Most patients recover fully from mTBI, but 15% to 29% of patients have persistent neurocognitive problems. Although a partially organic origin is considered likely, little brain imaging evidence exists for this assumption. The aims of the present study were to establish the prevalence of posttraumatic lesions in mTBI patients on MR images and to assess the relation between these imaging findings and posttraumatic symptoms, Secondly, we explored the value of early posttraumatic single-photon emission CT (SPECT) for the evaluation of mTBI, METHODS: Twenty-one consecutive patients were included in the study. Patients underwent MR examination, technetium-99m hexamethylpropylene amine oxime SPECT, and neurocognitive assessment within 5 days after injury. Neurocognitive follow-up was conducted 2 and 6 months after injury, and MR imaging was repeated after 6 months. Lesion size and brain atrophy were measured on the MR studies. RESULTS: Twelve (57%) of 21 patients had abnormal MR findings, and 11 (61%) of 18 had abnormal SPECT findings. Patients with abnormal MR or SPECT findings had brain atrophy at follow-up. The mean neurocognitive performance of all subjects was within normal range. There was no difference in neurocognitive performance between patients with normal and abnormal MR findings, Patients with abnormal MR findings only showed significantly slower reaction times during a reaction-time task. Seven patients had persistent neurocognitive complaints and one patient met the criteria for a postconcussional syndrome, CONCLUSION: Brain lesions are common after mTBI; up to 77% of patients may have abnormal findings either on MR images or SPECT scans, and these lesions may lead to brain atrophy, The association between hypoperfusion seen on acute SPECT and brain atrophy after 6 months suggests the possibility of (secondary) ischemic brain damage. There is only a weak correlation between neuroimaging findings and neurocognitive outcome.

Published
2001

6. Inflammatory activity assessment by F18 FDG-PET/CT in persistent symptomatic sarcoidosis

Author

Mostard, R.L., Mostard, R.L., Vöö, S., van Kroonenburgh, M.J.P.G., Verschakelen, J.A., Wijnen, P.A.H.M., Nelemans, P.J., Erckens, R.J., Drent, M., Mostard, R.L., Mostard, R.L., Vöö, S., van Kroonenburgh, M.J.P.G., Verschakelen, J.A., Wijnen, P.A.H.M., Nelemans, P.J., Erckens, R.J., and Drent, M.

Abstract

Background: Establishing inflammatory activity in sarcoidosis patients with persistent disabling symptoms is important. Whole body F-18-FDG PET/CT (PET) appeared to be a sensitive method to detect inflammatory activity in newly diagnosed symptomatic sarcoidosis. The aim was to assess the presence of inflammatory activity using PET in sarcoidosis patients with unexplained persistent disabling symptoms and the association between PET findings and serological inflammatory markers. Methods: Sarcoidosis patients who underwent a PET between June 2005 and June 2010 (n = 89), were retrospectively included. All PET scans were examined and positive findings were classified as thoracic and/or extrathoracic. As serological markers of inflammatory activity angiotensine-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), and neopterine were considered. Results: In 65/89 (73%) of the studied patients PET was positive, 52 of them (80%) had serological signs of inflammatory activity. In 14/15 patients with a Chest X-ray stage IV PET was positive. In 80% of the PET positive patients extrathoracic inflammatory activity was found. Sensitivity of combined serological inflammatory markers for the presence of inflammatory activity as detected by PET was 80%, specificity 100%, positive predictive value 100%, negative predictive value 65%. Conclusions: The majority of sarcoidosis patients with persistent disabling symptoms, even those with radiological stage IV, had PET positive findings with remarkably 80% extrathoracic lesions. In 20% PET was positive without signs of serological inflammatory activity. PET appeared to be of additional value to assess inflammatory activity in patients with persistent symptoms in the absence of signs of serological inflammatory activity and to detect extrathoracic lesions.

Published
2011

7. Endocriene klieren en tumoren

Author

Krenning, Eric, Oei, HY, Camps, J.A.J., van Kroonenburgh, M.J.P.G., van Urk, P., Wiarda, K.S., and Radiology & Nuclear Medicine

Published
1999

8. Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD).

Author

Vles, J.S.H., Vles, J.S.H., Feron, F.J.M., Hendriksen, J.G.M., Jolles, J., van Kroonenburgh, M.J.P.G., Weber, W.E.J., Vles, J.S.H., Vles, J.S.H., Feron, F.J.M., Hendriksen, J.G.M., Jolles, J., van Kroonenburgh, M.J.P.G., and Weber, W.E.J.

Abstract

Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD). Vles JS, Feron FJ, Hendriksen JG, Jolles J, van Kroonenburgh MJ, Weber WE. Department of Child Neurology, University Hospital Maastricht, Maastricht, The Netherlands. jvle@sneu.azm.nl Adults suffering from Attention Deficit Hyperactivity Disorder (ADHD) are known to have disturbed central dopaminergic transmission. With Single Photon Emission Computed Tomography (SPECT) we studied brain dopamine transporter and receptor activity in six boys with ADHD. Three months after initiation of treatment with methylphenidate we found a down-regulation of the post-synaptic dopamine receptor with a maximum of 20 % and a down-regulation of the dopamine transporter with a maximum of 74.7 % in the striatal system. This corresponded to a positive clinical response evaluated by neuropsychological questionnaires and tests. We suggest that dopamine transporter imaging by SPECT might be used to monitor psychostimulant treatment in children suffering from ADHD

Published
2003

10. SPECT in the diagnosis of Alzheimer's disease and multi-infarct-dementia

Author

Weinstein, H.C., primary, Haan, J., additional, van Royen, E.O., additional, Derix, M.M.A., additional, Lanser, J.B.K., additional, van der Zant, F., additional, Dunnewold, R.J.W., additional, van Kroonenburgh, M.J.P.G., additional, Pauwels, E.K.J., additional, van der Velde, E.A., additional, Hijdra, A., additional, and Buruma, O.J.S., additional

Published
1991
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11. Bone mineral density in patients with classic galactosaemia.

Author

Rubio-Gozalbo, M.E., Hamming, S., van Kroonenburgh, M.J.P.G., Bakker, J.A., Vermeer, C., and Forget, P. Ph.

Subjects
BONES, GALACTOSEMIA
Abstract

Evaluates bone mineral density (BMD) in children with classic galactosemia. Normal levels of dietary calcium intake, blood calcium, phosphate, vitamin D metabolites, parathormone and bone alkaline phosphatase in the children; Decreased BMD in children of both sexes with classic galactosemia under dietary treatment.

Published
2002
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12. Side-Effects of Monoclonal Antibody Infusions for the Diagnosis and Treatment of Cancer

Author

van der Linden, E.F.H., van Kroonenburgh, M.J.P.G., and Pauwels, E.K.J.

Abstract

This literature review presents an inventory of the nature and incidence of side-effects that arise from the clinical application of monoclonal antibodies (MoAb) for the diagnosis and treatment of cancer. Most side-effects occurred during therapy. Toxic reactions, such as fever, sweating and chills, were more common than immunological skin reactions; they were observed predominantly in association with the elimination of circulating target cells. Dosage and rate of administration of the MoAb appeared to have little influence on the reactions, which disappeared quickly and did not necessitate discontinuation of treatment. Serum sickness, anaphylactic reactions and bronchospasms were not common; the patients reacted quickly to the indicated therapy. Prevention of the side-effects described here, especially during diagnostic applications, was such that they need not form a barrier to the clinical use of MoAb.

Published
1988
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