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783 results on '"van Kerrebroeck, Philip"'

7. Inclusion of functional measures and frailty in the development and evaluation of medicines for older adults

Author

Denkinger, Michael, Knol, Wilma, Cherubini, Antonio, Simonds, Anita, Lionis, Christos, Lacombe, Denis, Petelos, Elena, McCarthy, Mary, Ouvrard, Patrick, Van Kerrebroeck, Philip, Szymański, Piotr, Cupelli, Amelia, Laslop, Andrea, Koch, Armin, Sepodes, Bruno, Torre, Carla, Rönnemaa, Elina, Bałkowiec-Iskra, Ewa, Herdeiro, Maria Teresa, Rosa, Mário Miguel, Trauffler, Martine, Mirošević Skvrce, Nikica, Mayrhofer, Sabine, Berntgen, Michael, Silva, Ivana, and Cerreta, Francesca

Published
2023
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8. Two-year outcomes of the ARTISAN-SNM study for the treatment of urinary urgency incontinence using the Axonics rechargeable sacral neuromodulation system.

Author

Pezzella, Andrea, McCrery, Rebecca, Lane, Felicia, Benson, Kevin, Taylor, Chris, Padron, Osvaldo, Blok, Bertil, de Wachter, Stefan, Gruenenfelder, Jennifer, Pakzad, Mahreen, Perrouin-Verbe, Marie-Aimee, van Kerrebroeck, Philip, Mangel, Jeffrey, Peters, Kenneth, Kennelly, Michael, Shapiro, Andrew, Lee, Una, Comiter, Craig, Mueller, Margaret, and Goldman, Howard B

Subjects
clinical trial, implantable neurostimulator, overactive bladder, sacral neuromodulation, urinary urgency incontinence, Clinical Sciences, Neurosciences, Urology & Nephrology
Abstract

AimsSacral neuromodulation (SNM) is a guideline-recommended treatment with proven therapeutic benefit for urinary urgency incontinence (UUI) patients. The Axonics® System is the first Food and Drug Administration-approved rechargeable SNM system and is designed to deliver therapy for a minimum of 15 years. The ARTISAN-SNM study was designed to evaluate UUI participants treated with the Axonics System. Two-year follow-up results are presented.MethodsOne hundred and twenty-nine UUI participants underwent implantation with the Axonics System. Therapeutic response rate, participant quality of life (QoL), and satisfaction were determined using 3-day voiding diaries, ICIQ-OABqol, and satisfaction questionnaires. Participants were considered responders if they had a 50% or greater reduction in UUI episodes post-treatment. As-treated and Completers analyses are presented.ResultsAt 2 years, 93% of the participants (n = 121 Completers at 2 years) were therapy responders, of which 82% achieved ≥ 75% reduction in UUI episodes and 37% were dry (100% reduction). Daily UUI episodes reduced from 5.6 ± 0.3 at baseline to 1.0 ± 0.2 at 2 years. Statistically significant improvements in ICIQ-OABqol were reported. All participants were able to recharge their device and 94% of participants reported that the recharging frequency and duration were acceptable. Participant demographics nor condition severity were correlated with clinical outcomes or recharging experience. No unanticipated or serious device-related adverse events occurred.ConclusionsAt 2 years, participants treated with the Axonics System demonstrated sustained safety and efficacy, high levels of satisfaction with therapy and recharging. Participant-related factors were not associated with efficacy or recharging outcomes, indicating the reported results are applicable to a diverse population.

Published
2021

9. One‐year outcomes of the ARTISAN‐SNM study with the Axonics System for the treatment of urinary urgency incontinence

Author

Benson, Kevin, McCrery, Rebecca, Taylor, Chris, Padron, Osvaldo, Blok, Bertil, Wachter, Stefan, Pezzella, Andrea, Gruenenfelder, Jennifer, Pakzad, Mahreen, Perrouin‐Verbe, Marie‐Aimee, Van Kerrebroeck, Philip, Mangel, Jeffrey, Peters, Kenneth, Kennelly, Michael, Shapiro, Andrew, Lee, Una, Comiter, Craig, Mueller, Margaret, Goldman, Howard, and Lane, Felicia

Subjects
Clinical Trials and Supportive Activities, Bioengineering, Clinical Research, Aging, Urologic Diseases, Renal and urogenital, Adult, Aged, Aged, 80 and over, Electric Stimulation Therapy, Electrodes, Implanted, Fecal Incontinence, Female, Follow-Up Studies, Humans, Lumbosacral Plexus, Male, Middle Aged, Patient Satisfaction, Prostheses and Implants, Quality of Life, Surveys and Questionnaires, Treatment Outcome, Urinary Incontinence, Urge, Urinary Retention, Urologic Surgical Procedures, Young Adult, clinical trial, implantable neurostimulator, overactive bladder, sacral neuromodulation, urinary urgency incontinence, Clinical Sciences, Neurosciences, Urology & Nephrology
Abstract

AimsSacral neuromodulation (SNM) is a guideline-recommended treatment for voiding dysfunction including urgency, urge incontinence, and nonobstructive retention as well as fecal incontinence. The Axonics® System is a miniaturized, rechargeable SNM system designed to provide therapy for at least 15 years, which is expected to significantly reduce revision surgeries as it will not require replacement as frequently as the non-rechargeable SNM system. The ARTISAN-SNM study is a pivotal study designed to treat patients with urinary urgency incontinence (UUI). Clinical results at 1-year are presented.MethodsA total of 129 eligible UUI patients were treated. All participants were implanted with a quadripolar tined lead and neurostimulator in a single procedure. Efficacy data were collected using a 3-day bladder diary, a validated quality of life questionnaire (ICIQ-OABqol), and a participant satisfaction questionnaire. Therapy responders were defined as participants with ≥50% reduction in UUI episodes compared to baseline. Data were analyzed on all 129 participants.ResultsAt 1 year, 89% of the participants were therapy responders. The average UUI episodes per day reduced from 5.6 ± 0.3 at baseline to 1.4 ± 0.2. Participants experienced an overall clinically meaningful improvement of 34 points on the ICIQ-OABqol questionnaire. All study participants (100%) were able to recharge their device at 1 year, and 96% of participants reported that the frequency and duration of recharging was acceptable. There were no serious device-related adverse events.ConclusionsThe Axonics System is safe and effective at 1 year, with 89% of participants experiencing clinically and statistically significant improvements in UUI symptoms.

Published
2020

25. Inclusion of functional measures and frailty in the development and evaluation of medicines for older adults

Author

MS Geriatrie, Circulatory Health, Denkinger, Michael, Knol, Wilma, Cherubini, Antonio, Simonds, Anita, Lionis, Christos, Lacombe, Denis, Petelos, Elena, McCarthy, Mary, Ouvrard, Patrick, Van Kerrebroeck, Philip, Szymański, Piotr, Cupelli, Amelia, Laslop, Andrea, Koch, Armin, Sepodes, Bruno, Torre, Carla, Rönnemaa, Elina, Bałkowiec-Iskra, Ewa, Herdeiro, Maria Teresa, Rosa, Mário Miguel, Trauffler, Martine, Mirošević Skvrce, Nikica, Mayrhofer, Sabine, Berntgen, Michael, Silva, Ivana, Cerreta, Francesca, MS Geriatrie, Circulatory Health, Denkinger, Michael, Knol, Wilma, Cherubini, Antonio, Simonds, Anita, Lionis, Christos, Lacombe, Denis, Petelos, Elena, McCarthy, Mary, Ouvrard, Patrick, Van Kerrebroeck, Philip, Szymański, Piotr, Cupelli, Amelia, Laslop, Andrea, Koch, Armin, Sepodes, Bruno, Torre, Carla, Rönnemaa, Elina, Bałkowiec-Iskra, Ewa, Herdeiro, Maria Teresa, Rosa, Mário Miguel, Trauffler, Martine, Mirošević Skvrce, Nikica, Mayrhofer, Sabine, Berntgen, Michael, Silva, Ivana, and Cerreta, Francesca

Published
2023

29. Nocturia and Antidiuretic Pharmacotherapy

Author

Van Kerrebroeck, Philip E. V., Weiss, MD, FACS, Jeffrey P., editor, Blaivas, MD, Jerry G., editor, Van Kerrebroeck, MD, PhD, MMSc, Philip E. V., editor, and Wein, MD, FACS, PhD(hon), Alan J., editor

Published
2012
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43. Patient-tailored healthcare and tibial nerve neuromodulation in the treatment of patients with overactive bladder symptoms

Author

Urologie Medisch volwassenen, Te Dorsthorst, Manon, Digesu, Alex, van Kerrebroeck, Philip, Elneil, Sohier, van Breda, Jetske, Janssen, Dick, Martens, Frank, van Balken, Michael, Heesakkers, John, Urologie Medisch volwassenen, Te Dorsthorst, Manon, Digesu, Alex, van Kerrebroeck, Philip, Elneil, Sohier, van Breda, Jetske, Janssen, Dick, Martens, Frank, van Balken, Michael, and Heesakkers, John

Published
2022

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