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293 results on '"van Ittersum, Frans J"'

1. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Ahn, Curie, Berger, Stefan P., Caskey, Fergus J., Cho, Min Hyun, Cho, Heeyeon, Dekker, Friedo W., Diwan, Vishal, Drechsler, Christiane, Eckardt, Kai-Uwe, Evans, Marie, Ferreiro, Alejandro, Floege, Jürgen, Gadola, Liliana, Haller, Hermann, Han, Kyung Hee, Healy, Helen G., Heerspink, Hiddo Lambers, Hemmelder, Marc, Hiemstra, Thomas, Hilbrands, Luuk, Kim, Seong Heon, Klyprayong, Pinkaew, Köttgen, Anna, Kronenberg, Florian, Lamadrid, Veronica, Lee, Joo Hoo, Mark, Patrick, Matheson, Matt, Mi, Eun, Noppakun, Kajohnsak, Oefner, Peter, Panaput, Thanachai, Park, Young Seo, Prokosch, Hans-Ulrich, Reis, André, Rios, Pablo, Rosivall, Laszlo, Rotmans, Joris I., Sackeyfio, Alfred, Sangthawan, Pornpen, Schmid, Matthias, Shin, Jae Il, Silavarino, Ricardo, Sitter, Thomas, Sommerer, Claudia, Szymczak, Maciej, Torino, Claudia, Toth, Janos, van Ittersum, Frans J., Venuthurupalli, Sree Krishna, Verhaar, Marianne C., Wang, Zaimin, Wanner, Christoph, Wiecek, Andrzej, Wolf, Gunter, de Zeeuw, Dick, Zhang, Luxia, Zheng, Yuyan, Zhao, Ming-Hui, Zietse, Robert, Canney, Mark, Induruwage, Dilshani, Tang, Mila, Alencar de Pinho, Natalia, Er, Lee, Zhao, Yinshan, Djurdjev, Ognjenka, Ahn, Yo Han, Behnisch, Rouven, Calice-Silva, Viviane, Chesnaye, Nicholas C., de Borst, Martin H., Dember, Laura M., Dionne, Janis, Ebert, Natalie, Eder, Susanne, Fenton, Anthony, Fukagawa, Masafumi, Furth, Susan L., Hoy, Wendy E., Imaizumi, Takahiro, Jager, Kitty J., Jha, Vivekanand, Kang, Hee Gyung, Kitiyakara, Chagriya, Mayer, Gert, Oh, Kook-Hwan, Onu, Ugochi, Pecoits-Filho, Roberto, Reichel, Helmut, Richards, Anna, Schaefer, Franz, Schaeffner, Elke, Scheppach, Johannes B., Sola, Laura, Ulasi, Ifeoma, Wang, Jinwei, Yadav, Ashok K., Zhang, Jianzhen, Feldman, Harold I., Taal, Maarten W., Stengel, Bénédicte, and Levin, Adeera

Published
2023
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3. The association and contribution of gender-related characteristics to prevalent chronic kidney disease in women and men in a multi-ethnic population - The HELIUS study.

Author

Vosters, Taryn G., Kingma, Frouke M., Stel, Vianda S., Jager, Kitty J., van Ittersum, Frans J., van den Born, Bert-Jan H., Vogt, Liffert, and van Valkengoed, Irene G. M.

Subjects
CHRONIC kidney failure, OCCUPATIONAL segregation, PART-time employment, POISSON regression, ETHNIC groups
Abstract

In chronic kidney disease (CKD), prevalence differences between sexes have been reported. While biological factors have been investigated, research on sociocultural factors is scarce. We explore the extent gender-related characteristics associate with, and contribute to, CKD prevalence in women and men in a multi-ethnic population. Cross-sectional analyses were performed on data of 12,221 women and 8,930 men aged 18–70 years across six ethnic groups from the HELIUS Study. Using age-, education-, and ethnicity adjusted Poisson regression, we determined associations between time spent on housework; primary earner status; employment status; and occupational segregation, and CKD. Population attributable fractions estimated the contribution to CKD and the extent traditional CKD risk factors explained these contributions. In women, associations with CKD were found for doing little housework, part-time work, and unemployment. In men, primary-earnership and unemployment were associated. Associations aligned across ethnic groups. Estimated contributions ranged from 1.8% for women doing little housework to 26.5% for part-time employment and 12.1% for unemployment to 37.5% for primary-earnership in men, and were hardly explained by traditional risk factors. In our study, gender-related characteristics are associated with CKD in women and men across ethnic groups. Contributions to population prevalence may hardly be explained by CKD risk factors. Lay Summary: The prevalence of chronic kidney disease (CKD) differs between women and men. We explored to what extent the risk may be associated with sociocultural expectations for women and men. We analysed data of 12,221 women and 8,930 men from six different ethnic groups. CKD was more common in all women who did little housework, worked part-time or were unemployed, and in men whose financial contribution was equal to their partners or who were unemployed. The higher risk of CKD was not explained by a higher occurrence of known risk factors. In future, specific policies or targeted interventions may be developed to reduce the risk of CKD overall and in certain population subgroups. Highlights: This study found that several gender-related characteristics were associated with higher CKD prevalence, specifically low amounts of time spent on household work and working part-time in women and having an equal financial contribution and being unemployed in men. Ethnicity also influenced these results. The contribution of these characteristics to the prevalence in the population was not explained by differences in traditional risk factors. In future, specific policies or targeted interventions may be developed to reduce the risk of CKD overall and in certain population subgroups. [ABSTRACT FROM AUTHOR]

Published
2025
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8. Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

Author

CTI Otten, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Unit SKIM, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G, Wisse, Bram W, Reteig, Leon, Gruijters, Maartje L, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, Otten, Henny G, CTI Otten, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Unit SKIM, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G, Wisse, Bram W, Reteig, Leon, Gruijters, Maartje L, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, and Otten, Henny G

Published
2024

9. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author

Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.

Abstract

In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants.

Published
2024

10. Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation

Author

Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, Otten, Henny G., Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Reteig, Leon, Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Senev, Aleksandar, Naesens, Maarten, Heidt, Sebastiaan, and Otten, Henny G.

Abstract

In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs. irrelevant HLA antibodies. To evaluate which donor epitope-specific HLA antibodies (DESAs) are clinically important in kidney graft survival, relevant and irrelevant DESAs were discerned in a Dutch cohort of 4690 patients using Kaplan–Meier analysis and tested in a cox proportional hazard (CPH) model including nonimmunological variables. Pre-transplant DESAs were detected in 439 patients (9.4%). The presence of certain clinically relevant DESAs was significantly associated with increased risk on graft loss in deceased donor transplantations (p < 0.0001). The antibodies recognized six epitopes of HLA Class I, 3 of HLA-DR, and 1 of HLA-DQ, and most antibodies were directed to HLA-B (47%). Fifty-three patients (69.7%) had DESA against one donor epitope (range 1–5). Long-term graft survival rate in patients with clinically relevant DESA was 32%, rendering DESA a superior parameter to classical DSA (60%). In the CPH model, the hazard ratio (95% CI) of clinically relevant DESAs was 2.45 (1.84–3.25) in deceased donation, and 2.22 (1.25–3.95) in living donation. In conclusion, the developed model shows the deleterious effect of clinically relevant DESAs on graft outcome which outperformed traditional DSA-based risk analysis on antigen level.

Published
2024

11. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival

Author

CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, Otten, Henny G., CTI Otten, CTI, CDL Cluster Speciële Diagnostiek, Cancer, Infection & Immunity, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Unit SKIM, CTI CFF, Kardol-Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Kroesen, Bart Jan, Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., Heidt, Sebastiaan, and Otten, Henny G.

Published
2024

12. Antibodies against ARHGDIB are associated with long-term kidney graft loss

Author

Kamburova, Elena G., Gruijters, Maartje L., Kardol-Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Melchers, Rowena C.A., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J.A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christina E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Hoitsma, Andries, van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.

Published
2019
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13. Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease

Author

Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Fukagawa, Masafumi, Fujii, Naohiki, Maruyama, Shoichi, Imaizumi, Takahiro, Hoy, Wendy E., Zhang, Jianzhen, Wang, Zaimin, Healy, Helen G., Alencar de Pinho, Natalia, Stengel, Bénédicte, Massy, Ziad A., Combe, Christian, Laville, Maurice, Filho, Roberto Pecoits, Lopes, Antonio, Reichel, Helmut, Robinson, Bruce, Pisoni, Ronald, Bieber, Brian, Tu, Charlotte, Kitiyakara, Chagriya, Sangthawan, Pornpen, Pichaiwong, Warangkana, Klyprayong, Pinkaew, Feldman, Harold I., Orlandi, Paula, Townsend, Raymond, Go, Alan, Wang, Jinwei, Zhang, Luxia, Eckardt, Kai-Uwe, Jha, Vivekanand, Kumar, Vivek, Yadav, Ashok Kumar, Baid-Agrawal, Seema, Oh, Kook-Hwan, Ahn, Curie, Chae, Dong Wan, Han, Seung Hyeok, Sola, Laura, Rios, Pablo G., Gadola, Liliana, Lamadrid, Veronica, Eder, Susanne, Leierer, Johannes, Kerschbaum, Julia, de Borst, Martin H., Van Ittersum, Frans J., Van den Brand, Jan A., De Jong, Maarten A., Taal, Maarten W., Shardlow, Adam, Pecoits-Filho, Roberto, de Borst, Martin, and Taal, Maarten

Published
2019
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15. Sex differences in CKD risk factors across ethnic groups

Author

Vosters, Taryn G, primary, Kingma, Frouke M, additional, Stel, Vianda S, additional, van den Born, Bert-Jan H, additional, Huisman, Brechje J M V, additional, van Ittersum, Frans J, additional, Jager, Kitty J, additional, Vogt, Liffert, additional, and van Valkengoed, Irene G M, additional

Published
2024
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16. Determination of the clinical relevance of donor epitope‐specific HLA‐antibodies in kidney transplantation

Author

Kardol‐Hoefnagel, Tineke, primary, Senejohnny, Danial Mohammadi, additional, Kamburova, Elena G., additional, Wisse, Bram W., additional, Reteig, Leon, additional, Gruijters, Maartje L., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Melchers, Rowena C. A., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Bemelman, Frederike J., additional, Senev, Aleksandar, additional, Naesens, Maarten, additional, Heidt, Sebastiaan, additional, and Otten, Henny G., additional

Published
2024
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17. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Canney, Mark, primary, Induruwage, Dilshani, additional, Tang, Mila, additional, Alencar de Pinho, Natalia, additional, Er, Lee, additional, Zhao, Yinshan, additional, Djurdjev, Ognjenka, additional, Ahn, Yo Han, additional, Behnisch, Rouven, additional, Calice-Silva, Viviane, additional, Chesnaye, Nicholas C., additional, de Borst, Martin H., additional, Dember, Laura M., additional, Dionne, Janis, additional, Ebert, Natalie, additional, Eder, Susanne, additional, Fenton, Anthony, additional, Fukagawa, Masafumi, additional, Furth, Susan L., additional, Hoy, Wendy E., additional, Imaizumi, Takahiro, additional, Jager, Kitty J., additional, Jha, Vivekanand, additional, Kang, Hee Gyung, additional, Kitiyakara, Chagriya, additional, Mayer, Gert, additional, Oh, Kook-Hwan, additional, Onu, Ugochi, additional, Pecoits-Filho, Roberto, additional, Reichel, Helmut, additional, Richards, Anna, additional, Schaefer, Franz, additional, Schaeffner, Elke, additional, Scheppach, Johannes B., additional, Sola, Laura, additional, Ulasi, Ifeoma, additional, Wang, Jinwei, additional, Yadav, Ashok K., additional, Zhang, Jianzhen, additional, Feldman, Harold I., additional, Taal, Maarten W., additional, Stengel, Bénédicte, additional, Levin, Adeera, additional, Ahn, Curie, additional, Berger, Stefan P., additional, Caskey, Fergus J., additional, Cho, Min Hyun, additional, Cho, Heeyeon, additional, Dekker, Friedo W., additional, Diwan, Vishal, additional, Drechsler, Christiane, additional, Eckardt, Kai-Uwe, additional, Evans, Marie, additional, Ferreiro, Alejandro, additional, Floege, Jürgen, additional, Gadola, Liliana, additional, Haller, Hermann, additional, Han, Kyung Hee, additional, Healy, Helen G., additional, Heerspink, Hiddo Lambers, additional, Hemmelder, Marc, additional, Hiemstra, Thomas, additional, Hilbrands, Luuk, additional, Kim, Seong Heon, additional, Klyprayong, Pinkaew, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Lamadrid, Veronica, additional, Lee, Joo Hoo, additional, Mark, Patrick, additional, Matheson, Matt, additional, Mi, Eun, additional, Noppakun, Kajohnsak, additional, Oefner, Peter, additional, Panaput, Thanachai, additional, Park, Young Seo, additional, Prokosch, Hans-Ulrich, additional, Reis, André, additional, Rios, Pablo, additional, Rosivall, Laszlo, additional, Rotmans, Joris I., additional, Sackeyfio, Alfred, additional, Sangthawan, Pornpen, additional, Schmid, Matthias, additional, Shin, Jae Il, additional, Silavarino, Ricardo, additional, Sitter, Thomas, additional, Sommerer, Claudia, additional, Szymczak, Maciej, additional, Torino, Claudia, additional, Toth, Janos, additional, van Ittersum, Frans J., additional, Venuthurupalli, Sree Krishna, additional, Verhaar, Marianne C., additional, Wang, Zaimin, additional, Wanner, Christoph, additional, Wiecek, Andrzej, additional, Wolf, Gunter, additional, de Zeeuw, Dick, additional, Zhang, Luxia, additional, Zheng, Yuyan, additional, Zhao, Ming-Hui, additional, and Zietse, Robert, additional

Published
2023
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18. Toward a sensible single antigen bead cut-off based on kidney graft survival

Author

Wisse, Bram W., Kamburova, Elena G., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C.A.D., Plaisier, Loes, Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Junior N.M., Swelsen, Wendy, van der Pant, Karlijn A.M.I., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Frederike J., Hoitsma, Andries J., van der Boog, Paul J.M., de Fijter, Johan W., Betjes, Michiel G.H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., and Otten, Henny G.

Published
2018
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21. Technique failure in peritoneal dialysis: Modifiable causes and patient-specific risk factors

Author

Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Bonenkamp, Anna A, der Sluijs, Anita van Eck van, Dekker, Friedo W, Struijk, Dirk G, de Fijter, Carola Wh, Vermeeren, Yolande M, van Ittersum, Frans J, Verhaar, Marianne C, van Jaarsveld, Brigit C, Abrahams, Alferso C, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, Bonenkamp, Anna A, der Sluijs, Anita van Eck van, Dekker, Friedo W, Struijk, Dirk G, de Fijter, Carola Wh, Vermeeren, Yolande M, van Ittersum, Frans J, Verhaar, Marianne C, van Jaarsveld, Brigit C, and Abrahams, Alferso C

Published
2023

22. Supplemental Material, sj-pdf-1-ptd-10.1177_08968608221077461 - Technique failure in peritoneal dialysis: Modifiable causes and patient-specific risk factors

Author

Bonenkamp, Anna A, der Sluijs, Anita van Eck van, Dekker, Friedo W, Struijk, Dirk G, de Fijter, Carola WH, Vermeeren, Yolande M, van Ittersum, Frans J, Verhaar, Marianne C, van Jaarsveld, Brigit C, and Abrahams, Alferso C

Subjects
Medicine
Abstract

Supplemental Material, sj-pdf-1-ptd-10.1177_08968608221077461 for Technique failure in peritoneal dialysis: Modifiable causes and patient-specific risk factors by Anna A Bonenkamp, Anita van Eck van der Sluijs, Friedo W Dekker, Dirk G Struijk, Carola WH de Fijter, Yolande M Vermeeren, Frans J van Ittersum, Marianne C Verhaar, Brigit C van Jaarsveld, Alferso C Abrahams and on behalf of the DOMESTICO study group. in Peritoneal Dialysis International

Published
2023
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23. Nocturnal Hemodialysis Leads to Improvement in Physical Performance in Comparison with Conventional Hemodialysis

Author

Dam, Manouk, Weijs, Peter J. M., van Ittersum, Frans J., Hoekstra, Tiny, Douma, Caroline E., van Jaarsveld, Brigit C., Lectoraat Voeding en Beweging, Urban Vitality, Internal medicine, AMS - Ageing & Vitality, APH - Aging & Later Life, Nephrology, ACS - Atherosclerosis & ischemic syndromes, and ACS - Diabetes & metabolism

Subjects
Nutrition and Dietetics, nocturnal hemodialysis (NHD), physical performance, protein-energy wasting (PEW), conventional hemodialysis (CHD), short physical performance battery (SPPB), quality of life (QOL), linear mixed models (LMM), Food Science
Abstract

End-stage kidney disease patients treated with conventional hemodialysis (CHD) are known to have impaired physical performance and protein-energy wasting (PEW). Nocturnal hemodialysis (NHD) was shown to improve clinical outcomes, but the evidence is limited on physical performance and PEW. We investigate whether NHD improves physical performance and PEW. This prospective, multicenter, non-randomized cohort study compared patients who changed from CHD (2–4 times/week 3–5 h) to NHD (2–3 times/week 7–8 h), with patients who continued CHD. The primary outcome was physical performance at 3, 6 and 12 months, assessed with the short physical performance battery (SPPB). Secondary outcomes were a 6-minute walk test (6MWT), physical activity monitor, handgrip muscle strength, KDQOL-SF physical component score (PCS) and LAPAQ physical activity questionnaire. PEW was assessed with a dietary record, dual-energy X-ray absorptiometry, bioelectrical impedance spectroscopy and subjective global assessment (SGA). Linear mixed models were used to analyze the differences between groups. This study included 33 patients on CHD and 32 who converted to NHD (mean age 55 ± 15.3). No significant difference was found in the SPPB after 1-year of NHD compared to CHD (+0.24, [95% confidence interval −0.51 to 0.99], p = 0.53). Scores of 6MWT, PCS and SGA improved (+54.3 [95%CI 7.78 to 100.8], p = 0.02; +5.61 [−0.51 to 10.7], p = 0.03; +0.71 [0.36 to 1.05], p < 0.001; resp.) in NHD patients, no changes were found in other parameters. We conclude that NHD patients did not experience an improved SPPB score compared to CHD patients; they did obtain an improved walking distance and self-reported PCS as well as SGA after 1-year of NHD, which might be related to the younger age of these patients.

Published
2023
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27. Validity and reliability of the Patient-Reported Outcomes Measurement Information System (PROMIS®) using computerized adaptive testing in patients with advanced chronic kidney disease

Author

van der Willik, Esmee M, primary, van Breda, Fenna, additional, van Jaarsveld, Brigit C, additional, van de Putte, Marlon, additional, Jetten, Isabelle W, additional, Dekker, Friedo W, additional, Meuleman, Yvette, additional, van Ittersum, Frans J, additional, and Terwee, Caroline B, additional

Published
2022
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28. Differences in hospitalisation between peritoneal dialysis and haemodialysis patients

Author

van Eck van der Sluijs, Anita, Bonenkamp, Anna A., van Wallene, Vera A., Hoekstra, Tiny, Lissenberg-Witte, Birgit I., Dekker, Friedo W., van Ittersum, Frans J., Verhaar, Marianne C., van Jaarsveld, Brigit C., Abrahams, Alferso C., van Eck van der Sluijs, Anita, Bonenkamp, Anna A., van Wallene, Vera A., Hoekstra, Tiny, Lissenberg-Witte, Birgit I., Dekker, Friedo W., van Ittersum, Frans J., Verhaar, Marianne C., van Jaarsveld, Brigit C., and Abrahams, Alferso C.

Abstract

Background: Dialysis is associated with frequent hospitalisations. Studies comparing hospitalisations between peritoneal dialysis (PD) and haemodialysis (HD) report conflicting results and mostly analyse data of patients that remain on their initial dialysis modality. This cohort study compares hospitalisations between PD and HD patients taking into account transitions between modalities. Methods: The Dutch nOcturnal and hoME dialysis Study To Improve Clinical Outcomes collected hospitalisation data of patients who started dialysis between 2012 and 2017. Primary outcome was hospitalisation rate, analysed with a multi-state model that attributed each hospitalisation to the current dialysis modality. Results: In total, 695 patients (252 PD, 443 HD) treated in 31 Dutch hospitals were included. The crude hospitalisation rate for PD was 2.3 (± 5.0) and for HD 1.4 (± 3.2) hospitalisations per patient-year. The adjusted hazard ratio for hospitalisation rate was 1.1 (95%CI 1.02–1.3) for PD compared with HD. The risk for first hospitalisation was 1.3 times (95%CI 1.1–1.6) higher for PD compared with HD during the first year after dialysis initiation. The number of hospitalisations and number of hospital days per patient-year were significantly higher for PD. The most common causes of PD and HD hospitalisations were peritonitis (23%) and vascular access-related problems (33%). Conclusion: PD was associated with higher hospitalisation rate, higher risk for first hospitalisation and higher number of hospitalisations compared with HD. Since the PD hospitalisations were mainly caused by peritonitis, more attention to infection prevention is necessary for reducing the number of hospitalisations in the future.

Published
2022

29. Differences in hospitalisation between peritoneal dialysis and haemodialysis patients

Author

Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, van Eck van der Sluijs, Anita, Bonenkamp, Anna A, van Wallene, Vera A, Hoekstra, Tiny, Lissenberg-Witte, Birgit I, Dekker, Friedo W, van Ittersum, Frans J, Verhaar, Marianne C, van Jaarsveld, Brigit C, Abrahams, Alferso C, DOMESTICO study group, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Nefrologie, van Eck van der Sluijs, Anita, Bonenkamp, Anna A, van Wallene, Vera A, Hoekstra, Tiny, Lissenberg-Witte, Birgit I, Dekker, Friedo W, van Ittersum, Frans J, Verhaar, Marianne C, van Jaarsveld, Brigit C, Abrahams, Alferso C, and DOMESTICO study group

Published
2022

30. Trends in home dialysis use differ among age categories in past two decades: A Dutch registry study

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A., Hoekstra, Tiny, Hemmelder, Marc H., van Eck van der Sluijs, Anita, Abrahams, Alferso C., van Ittersum, Frans J., van Jaarsveld, Brigit C., Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A., Hoekstra, Tiny, Hemmelder, Marc H., van Eck van der Sluijs, Anita, Abrahams, Alferso C., van Ittersum, Frans J., and van Jaarsveld, Brigit C.

Published
2022

34. Supplemental Material, sj-docx-1-ptd-10.1177_08968608221086734 - Symptom dimensions of anxiety and depression in patients receiving peritoneal dialysis compared to haemodialysis

Author

Nadort, Els, Schouten, Robbert W, Luijkx, Xander, Shaw, Prataap K Chandie, van Ittersum, Frans J, Smets, Yves FC, Vleming, Louis-Jean, Dekker, Friedo W, Broekman, Birit FPH, and Siegert, Carl EH

Subjects
Medicine
Abstract

Supplemental Material, sj-docx-1-ptd-10.1177_08968608221086734 for Symptom dimensions of anxiety and depression in patients receiving peritoneal dialysis compared to haemodialysis by Els Nadort, Robbert W Schouten, Xander Luijkx, Prataap K Chandie Shaw, Frans J van Ittersum, Yves FC Smets, Louis-Jean Vleming, Friedo W Dekker, Birit FPH Broekman and Carl EH Siegert in Peritoneal Dialysis International

Published
2022
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37. Itching in dialysis patients: impact on health-related quality of life and interactions with sleep problems and psychological symptoms—results from the RENINE/PROMs registry

Author

van der Willik, Esmee M, primary, Lengton, Robin, additional, Hemmelder, Marc H, additional, Hoogeveen, Ellen K, additional, Bart, Hans A J, additional, van Ittersum, Frans J, additional, ten Dam, Marc A G J, additional, Bos, Willem Jan W, additional, Dekker, Friedo W, additional, and Meuleman, Yvette, additional

Published
2022
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40. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author

Peereboom, Emma T. M., primary, Matern, Benedict M., additional, Tomosugi, Toshihide, additional, Niemann, Matthias, additional, Drylewicz, Julia, additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, van Reekum, Franka E., additional, Verhaar, Marianne C., additional, Kamburova, Elena G., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christien E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Azam, additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Fréderike J., additional, de Vries, Aiko P. J., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Otten, Henny G., additional, Heidt, Sebastiaan, additional, van Zuilen, Arjan D., additional, Kobayashi, Takaaki, additional, Geneugelijk, Kirsten, additional, and Spierings, Eric, additional

Published
2021
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41. The Biobank of Nephrological Diseases in the Netherlands cohort: the String of Pearls Initiative collaboration on chronic kidney disease in the university medical centers in the Netherlands

Author

Navis, Gerjan J., Blankestijn, Peter J., Deegens, Jeroen, De Fijter, Johan W., Homan van der Heide, Jaap J., Rabelink, Ton, Krediet, Raymond T., Kwakernaak, Arjan J., Laverman, Gozewijn D., Leunissen, Karel M., van Paassen, Pieter, Vervloet, Marc G., Wee, Pieter M. Ter, Wetzels, Jack F., Zietse, Robert, and van Ittersum, Frans J.

Published
2014
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42. Supplemental Material, sj-docx-1-ptd-10.1177_08968608211023263 - Key elements in selection of pre-dialysis patients for home dialysis

Author

Bonenkamp, Anna A, Reijnders, Tom D Y, der Sluijs, Anita van Eck van, Hagen, E Christiaan, Abrahams, Alferso C, van Ittersum, Frans J, and van Jaarsveld, Brigit C

Subjects
Medicine
Abstract

Supplemental Material, sj-docx-1-ptd-10.1177_08968608211023263 for Key elements in selection of pre-dialysis patients for home dialysis by Anna A Bonenkamp, Tom D Y Reijnders, Anita van Eck van der Sluijs, E Christiaan Hagen, Alferso C Abrahams, Frans J van Ittersum and Brigit C van Jaarsveld in Peritoneal Dialysis International

Published
2021
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45. Clinical presentation and long-term follow-up of dopamine beta hydroxylase deficiency

Author

Wassenberg, Tessa, Deinum, Jaap, van Ittersum, Frans J., Kamsteeg, Erik Jan, Pennings, Maartje, Verbeek, Marcel M., Wevers, Ron A., van Albada, Mirjam E., Kema, Ido P., Versmissen, Jorie, van den Meiracker, Ton, Lenders, Jacques W.M., Monnens, Leo, Willemsen, Michèl A., Wassenberg, Tessa, Deinum, Jaap, van Ittersum, Frans J., Kamsteeg, Erik Jan, Pennings, Maartje, Verbeek, Marcel M., Wevers, Ron A., van Albada, Mirjam E., Kema, Ido P., Versmissen, Jorie, van den Meiracker, Ton, Lenders, Jacques W.M., Monnens, Leo, and Willemsen, Michèl A.

Abstract

Dopamine beta hydroxylase (DBH) deficiency is an extremely rare autosomal recessive disorder with severe orthostatic hypotension, that can be treated with L-threo-3,4-dihydroxyphenylserine (L-DOPS). We aimed to summarize clinical, biochemical, and genetic data of all world-wide reported patients with DBH-deficiency, and to present detailed new data on long-term follow-up of a relatively large Dutch cohort. We retrospectively describe 10 patients from a Dutch cohort and 15 additional patients from the literature. We identified 25 patients (15 females) from 20 families. Ten patients were diagnosed in the Netherlands. Duration of follow-up of Dutch patients ranged from 1 to 21 years (median 13 years). All patients had severe orthostatic hypotension. Severely decreased or absent (nor)epinephrine, and increased dopamine plasma concentrations were found in 24/25 patients. Impaired kidney function and anemia were present in all Dutch patients, hypomagnesaemia in 5 out of 10. Clinically, all patients responded very well to L-DOPS, with marked reduction of orthostatic complaints. However, orthostatic hypotension remained present, and kidney function, anemia, and hypomagnesaemia only partially improved. Plasma norepinephrine increased and became detectable, while epinephrine remained undetectable in most patients. We confirm the core clinical characteristics of DBH-deficiency and the pathognomonic profile of catecholamines in body fluids. Impaired renal function, anemia, and hypomagnesaemia can be part of the clinical presentation. The subjective response to L-DOPS treatment is excellent and sustained, although the neurotransmitter profile in plasma does not normalize completely. Furthermore, orthostatic hypotension as well as renal function, anemia, and hypomagnesaemia improve only partially.

Published
2021

46. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author

Peereboom, Emma T.M., Matern, Benedict M., Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., de Vries, Aiko P.J., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Otten, Henny G., Heidt, Sebastiaan, van Zuilen, Arjan D., Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric, Peereboom, Emma T.M., Matern, Benedict M., Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., van Reekum, Franka E., Verhaar, Marianne C., Kamburova, Elena G., Seelen, Marc A.J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G.J., Voorter, Christien E., Wieten, Lotte, van Duijnhoven, Elly M., Gelens, Mariëlle A.C.J., Christiaans, Maarten H.L., van Ittersum, Frans J., Nurmohamed, Azam, Lardy, Neubury M., Swelsen, Wendy, van der Pant, Karlijn A., van der Weerd, Neelke C., ten Berge, Ineke J.M., Bemelman, Fréderike J., de Vries, Aiko P.J., de Fijter, Johan W., Betjes, Michiel G.H., Roelen, Dave L., Claas, Frans H., Otten, Henny G., Heidt, Sebastiaan, van Zuilen, Arjan D., Kobayashi, Takaaki, Geneugelijk, Kirsten, and Spierings, Eric

Abstract

CD4+ T-helper cells play an important role in alloimmune reactions following transplantation by stimulating humoral as well as cellular responses, which might lead to failure of the allograft. CD4+ memory T-helper cells from a previous immunizing event can potentially be reactivated by exposure to HLA mismatches that share T-cell epitopes with the initial immunizing HLA. Consequently, reactivity of CD4+ memory T-helper cells toward T-cell epitopes that are shared between immunizing HLA and donor HLA could increase the risk of alloimmunity following transplantation, thus affecting transplant outcome. In this study, the amount of T-cell epitopes shared between immunizing and donor HLA was used as a surrogate marker to evaluate the effect of donor-reactive CD4+ memory T-helper cells on the 10-year risk of death-censored kidney graft failure in 190 donor/recipient combinations using the PIRCHE-II algorithm. The T-cell epitopes of the initial theoretical immunizing HLA and the donor HLA were estimated and the number of shared PIRCHE-II epitopes was calculated. We show that the natural logarithm-transformed PIRCHE-II overlap score, or Shared T-cell EPitopes (STEP) score, significantly associates with the 10-year risk of death-censored kidney graft failure, suggesting that the presence of pre-transplant donor-reactive CD4+ memory T-helper cells might be a strong indicator for the risk of graft failure following kidney transplantation.

Published
2021

47. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation

Author

CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric, CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, and Spierings, Eric

Published
2021

48. The Impact of COVID-19 on the mental health of dialysis patients

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A., Druiventak, Theresia A., van Eck van der Sluijs, Anita, van Ittersum, Frans J., van Jaarsveld, Brigit C., Abrahams, Alferso C., the DOMESTICO study group, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A., Druiventak, Theresia A., van Eck van der Sluijs, Anita, van Ittersum, Frans J., van Jaarsveld, Brigit C., Abrahams, Alferso C., and the DOMESTICO study group

Published
2021

49. Key elements in selection of pre-dialysis patients for home dialysis

Author

Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A, Reijnders, Tom D Y, der Sluijs, Anita van Eck van, Hagen, E Christiaan, Abrahams, Alferso C, van Ittersum, Frans J, van Jaarsveld, Brigit C, Nefro Vasculaire Geneeskunde, MS Nefrologie, Circulatory Health, Bonenkamp, Anna A, Reijnders, Tom D Y, der Sluijs, Anita van Eck van, Hagen, E Christiaan, Abrahams, Alferso C, van Ittersum, Frans J, and van Jaarsveld, Brigit C

Published
2021

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