384 results on '"van Hylckama Vlieg, Astrid"'
Search Results
2. Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism
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Lindstrom, Sara, Wang, Lu, Smith, Erin, Gordon, William, Van Hylckama Vlieg, Astrid, De Andrade, Mariza, Brody, Jennifer, Pattee, Jack, Haessler, Jeffrey, Brumpton, Ben, Chasman, Daniel, Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri, MacDonald, James, Braekkan, Sigrid, Armasu, Sebastian, Pankratz, Nathan, Jackson, Rabecca, Nielsen, Jonas, Giulianini, Franco, Puurunen, Marja, Ibrahim, Manal, Heckbert, Susan, Bammler, Theo, Frazer, Kelly, McCauley, Bryan, Taylor, Kent, Pankow, James, Reiner, Alexander, Gabrielsen, Maiken, Deleuze, Jean-François, O'Donnell, Chris, Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits, Heit, John, Psaty, Bruce, Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul, Morange, Pierre-Emmanuel, Johnson, Andrew, Kabrhel, Christopher, Trégouët, David-Alexandre, Smith, Nicholas, Tan, Marcus C.B., Isom, Chelsea A., Liu, Yangzi, Wu, Lang, Zhou, Dan, and Gamazon, Eric R.
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- 2024
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3. Genome-wide investigation of exogenous female hormones, genetic variation, and venous thromboembolism risk
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Hasser, Emily K., Brody, Jennifer A., Bartz, Traci M., Thibord, Florian, Li-Gao, Ruifang, Kauko, Anni, Wiggins, Kerri L., Teder-Laving, Maris, Kim, Jihye, Munsch, Gaëlle, Haile, Helen G., Deleuze, Jean-Francois, van Hylckama Vlieg, Astrid, Wolberg, Alisa S., Boland, Anne, Morange, Pierre-Emmanuel, Kraft, Peter, Lowenstein, Charles J., Emmerich, Joseph, Sitlani, Colleen M., Suchon, Pierre, Rosendaal, Frits R., Niiranen, Teemu, Kabrhel, Christopher, Trégouët, David-Alexandre, and Smith, Nicholas L.
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- 2024
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4. Hormonal contraceptive use after a first venous thrombotic event and the risk of recurrence in premenopausal women
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Verlaan, Judith P.L., Stegeman, Bernadine H., Timp, Jasmijn F., Scheres, Luuk J.J., Flinterman, Linda E., Helmerhorst, Frans M., Rosendaal, Frits R., Cannegieter, Suzanne C., and van Hylckama Vlieg, Astrid
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- 2024
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5. Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
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Temprano‐Sagrera, Gerard, Sitlani, Colleen M, Bone, William P, Martin‐Bornez, Miguel, Voight, Benjamin F, Morrison, Alanna C, Damrauer, Scott M, de Vries, Paul S, Smith, Nicholas L, Sabater‐Lleal, Maria, Dehghan, Abbas, Heath, Adam S, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward‐Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook‐Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank WG, Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Liu, Melissa, Brown, Michael R, Conomos, Matthew P, Jhun, Min‐A, Chen, Ming‐Huei, de Maat, Moniek PM, Pankratz, Nathan, Peyser, Patricia A, Elliot, Paul, Wei, Peng, Wild, Philipp S, Morange, Pierre E, van der Harst, Pim, Yang, Qiong, Le, Ngoc‐Quynh, Marioni, Riccardo, Li, Ruifang, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J Wouter, Guo, Xiuqing, Lindstrom, Sara, Wang, Lu, Smith, Erin N, Gordon, William, de Andrade, Mariza, Brody, Jennifer A, Pattee, Jack W, Haessler, Jeffrey, Brumpton, Ben M, Chasman, Daniel I, Suchon, Pierre, Turman, Constance, Germain, Marine, MacDonald, James, and Braekkan, Sigrid K
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Genetics ,Biotechnology ,Human Genome ,Atherosclerosis ,Prevention ,Cardiovascular ,Hematology ,2.1 Biological and endogenous factors ,Aetiology ,Cardiovascular Diseases ,Factor XI ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Hemostasis ,Hemostatics ,Humans ,Phenotype ,Polymorphism ,Single Nucleotide ,Tissue Plasminogen Activator ,blood coagulation ,cardiovascular diseases ,genetic pleiotropy ,genome-wide association study ,hemostasis ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
BackgroundMulti-phenotype analysis of genetically correlated phenotypes can increase the statistical power to detect loci associated with multiple traits, leading to the discovery of novel loci. This is the first study to date to comprehensively analyze the shared genetic effects within different hemostatic traits, and between these and their associated disease outcomes.ObjectivesTo discover novel genetic associations by combining summary data of correlated hemostatic traits and disease events.MethodsSummary statistics from genome wide-association studies (GWAS) from seven hemostatic traits (factor VII [FVII], factor VIII [FVIII], von Willebrand factor [VWF] factor XI [FXI], fibrinogen, tissue plasminogen activator [tPA], plasminogen activator inhibitor 1 [PAI-1]) and three major cardiovascular (CV) events (venous thromboembolism [VTE], coronary artery disease [CAD], ischemic stroke [IS]), were combined in 27 multi-trait combinations using metaUSAT. Genetic correlations between phenotypes were calculated using Linkage Disequilibrium Score Regression (LDSC). Newly associated loci were investigated for colocalization. We considered a significance threshold of 1.85 × 10-9 obtained after applying Bonferroni correction for the number of multi-trait combinations performed (n = 27).ResultsAcross the 27 multi-trait analyses, we found 4 novel pleiotropic loci (XXYLT1, KNG1, SUGP1/MAU2, TBL2/MLXIPL) that were not significant in the original individual datasets, were not described in previous GWAS for the individual traits, and that presented a common associated variant between the studied phenotypes.ConclusionsThe discovery of four novel loci contributes to the understanding of the relationship between hemostasis and CV events and elucidate common genetic factors between these traits.
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- 2022
6. A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels
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Abe, Namiko, Abecasis, Gonçalo, Aguet, Francois, Albert, Christine, Almasy, Laura, Alonso, Alvaro, Ament, Seth, Anderson, Peter, Anugu, Pramod, Applebaum-Bowden, Deborah, Ardlie, Kristin, Arking, Dan, Arnett, Donna K, Ashley-Koch, Allison, Aslibekyan, Stella, Assimes, Tim, Auer, Paul, Avramopoulos, Dimitrios, Ayas, Najib, Balasubramanian, Adithya, Barnard, John, Barnes, Kathleen, Barr, R. Graham, Barron-Casella, Emily, Barwick, Lucas, Beaty, Terri, Beck, Gerald, Becker, Diane, Becker, Lewis, Beer, Rebecca, Beitelshees, Amber, Benjamin, Emelia, Benos, Takis, Bezerra, Marcos, Bielak, Larry, Bis, Joshua, Blackwell, Thomas, Blangero, John, Blue, Nathan, Boerwinkle, Eric, Bowden, Donald W., Bowler, Russell, Brody, Jennifer, Broeckel, Ulrich, Broome, Jai, Brown, Deborah, Bunting, Karen, Burchard, Esteban, Bustamante, Carlos, Buth, Erin, Cade, Brian, Cardwell, Jonathan, Carey, Vincent, Carrier, Julie, Carson, April P., Carty, Cara, Casaburi, Richard, Casas Romero, Juan P, Casella, James, Castaldi, Peter, Chaffin, Mark, Chang, Christy, Chang, Yi-Cheng, Chasman, Daniel, Chavan, Sameer, Chen, Bo-Juen, Chen, Wei-Min, Ida Chen, Yii-Der, Cho, Michael, Choi, Seung Hoan, Chuang, Lee-Ming, Chung, Mina, Chung, Ren-Hua, Clish, Clary, Comhair, Suzy, Conomos, Matthew, Cornell, Elaine, Correa, Adolfo, Crandall, Carolyn, Crapo, James, Cupples, L. Adrienne, Curran, Joanne, Curtis, Jeffrey, Custer, Brian, Damcott, Coleen, Darbar, Dawood, David, Sean, Davis, Colleen, Daya, Michelle, de Andrade, Mariza, de las Fuentes, Lisa, de Vries, Paul, DeBaun, Michael, Deka, Ranjan, DeMeo, Dawn, Devine, Scott, Dinh, Huyen, Doddapaneni, Harsha, Duan, Qing, Dugan-Perez, Shannon, Duggirala, Ravi, Durda, Jon Peter, Dutcher, Susan K., Eaton, Charles, Ekunwe, Lynette, El Boueiz, Adel, Ellinor, Patrick, Emery, Leslie, Erzurum, Serpil, Farber, Charles, Farek, Jesse, Fingerlin, Tasha, Flickinger, Matthew, Fornage, Myriam, Franceschini, Nora, Frazar, Chris, Fu, Mao, Fullerton, Stephanie M., Fulton, Lucinda, Gabriel, Stacey, Gan, Weiniu, Gao, Shanshan, Gao, Yan, Gass, Margery, Geiger, Heather, Gelb, Bruce, Geraci, Mark, Germer, Soren, Gerszten, Robert, Ghosh, Auyon, Gibbs, Richard, Gignoux, Chris, Gladwin, Mark, Glahn, David, Gogarten, Stephanie, Gong, Da-Wei, Goring, Harald, Graw, Sharon, Gray, Kathryn J., Grine, Daniel, Gross, Colin, Gu, C. Charles, Guan, Yue, Guo, Xiuqing, Gupta, Namrata, Haessler, Jeff, Hall, Michael, Han, Yi, Hanly, Patrick, Harris, Daniel, Hawley, Nicola L., He, Jiang, Heavner, Ben, Heckbert, Susan, Hernandez, Ryan, Herrington, David, Hersh, Craig, Hidalgo, Bertha, Hixson, James, Hobbs, Brian, Hokanson, John, Hong, Elliott, Hoth, Karin, Hsiung, Chao (Agnes), Hu, Jianhong, Hung, Yi-Jen, Huston, Haley, Hwu, Chii Min, Irvin, Marguerite Ryan, Jackson, Rebecca, Jain, Deepti, Jaquish, Cashell, Johnsen, Jill, Johnson, Andrew, Johnson, Craig, Johnston, Rich, Jones, Kimberly, Kang, Hyun Min, Kaplan, Robert, Kardia, Sharon, Kelly, Shannon, Kenny, Eimear, Kessler, Michael, Khan, Alyna, Khan, Ziad, Kim, Wonji, Kimoff, John, Kinney, Greg, Konkle, Barbara, Kooperberg, Charles, Kramer, Holly, Lange, Christoph, Lange, Ethan, Lange, Leslie, Laurie, Cathy, Laurie, Cecelia, LeBoff, Meryl, Lee, Jiwon, Lee, Sandra, Lee, Wen-Jane, LeFaive, Jonathon, Levine, David, Levy, Dan, Lewis, Joshua, Li, Xiaohui, Li, Yun, Lin, Henry, Lin, Honghuang, Lin, Xihong, Liu, Simin, Liu, Yongmei, Liu, Yu, Loos, Ruth J. F., Lubitz, Steven, Lunetta, Kathryn, Luo, James, Magalang, Ulysses, Mahaney, Michael, Make, Barry, Manichaikul, Ani, Manning, Alisa, Manson, JoAnn, Martin, Lisa, Marton, Melissa, Mathai, Susan, Mathias, Rasika, May, Susanne, McArdle, Patrick, McDonald, Merry-Lynn, McFarland, Sean, McGarvey, Stephen, McGoldrick, Daniel, McHugh, Caitlin, McNeil, Becky, Mei, Hao, Meigs, James, Menon, Vipin, Mestroni, Luisa, Metcalf, Ginger, Meyers, Deborah A, Mignot, Emmanuel, Mikulla, Julie, Min, Nancy, Minear, Mollie, Minster, Ryan L, Mitchell, Braxton D., Moll, Matt, Momin, Zeineen, Montasser, May E., Montgomery, Courtney, Muzny, Donna, Mychaleckyj, Josyf C, Nadkarni, Girish, Naik, Rakhi, Naseri, Take, Natarajan, Pradeep, Nekhai, Sergei, Nelson, Sarah C., Neltner, Bonnie, Nessner, Caitlin, Nickerson, Deborah, Nkechinyere, Osuji, North, Kari, O'Connell, Jeff, O'Connor, Tim, Ochs-Balcom, Heather, Okwuonu, Geoffrey, Pack, Allan, Paik, David T., Palmer, Nicholette, Pankow, James, Papanicolaou, George, Parker, Cora, Peloso, Gina, Peralta, Juan Manuel, Perez, Marco, Perry, James, Peters, Ulrike, Peyser, Patricia, Phillips, Lawrence S, Pleiness, Jacob, Pollin, Toni, Post, Wendy, Becker, Julia Powers, Boorgula, Meher Preethi, Preuss, Michael, Psaty, Bruce, Qasba, Pankaj, Qiao, Dandi, Qin, Zhaohui, Rafaels, Nicholas, Raffield, Laura, Rajendran, Mahitha, Ramachandran, Vasan S., Rao, D. C., Rasmussen-Torvik, Laura, Ratan, Aakrosh, Redline, Susan, Reed, Robert, Reeves, Catherine, Regan, Elizabeth, Reiner, Alex, Reupena, Muagututi‘a Sefuiva, Rice, Ken, Rich, Stephen, Robillard, Rebecca, Robine, Nicolas, Roden, Dan, Roselli, Carolina, Rotter, Jerome, Ruczinski, Ingo, Runnels, Alexi, Russell, Pamela, Ruuska, Sarah, Ryan, Kathleen, Sabino, Ester Cerdeira, Saleheen, Danish, Salimi, Shabnam, Salvi, Sejal, Salzberg, Steven, Sandow, Kevin, Sankaran, Vijay G., Santibanez, Jireh, Schwander, Karen, Schwartz, David, Sciurba, Frank, Seidman, Christine, Seidman, Jonathan, Sériès, Frédéric, Sheehan, Vivien, Sherman, Stephanie L., Shetty, Amol, Shetty, Aniket, Hui-Heng Sheu, Wayne, Shoemaker, M. Benjamin, Silver, Brian, Silverman, Edwin, Skomro, Robert, Smith, Albert Vernon, Smith, Jennifer, Smith, Josh, Smith, Nicholas, Smith, Tanja, Smoller, Sylvia, Snively, Beverly, Snyder, Michael, Sofer, Tamar, Sotoodehnia, Nona, Stilp, Adrienne M., Storm, Garrett, Streeten, Elizabeth, Su, Jessica Lasky, Sung, Yun Ju, Sylvia, Jody, Szpiro, Adam, Taliun, Daniel, Tang, Hua, Taub, Margaret, Taylor, Kent D., Taylor, Matthew, Taylor, Simeon, Telen, Marilyn, Thornton, Timothy A., Threlkeld, Machiko, Tinker, Lesley, Tirschwell, David, Tishkoff, Sarah, Tiwari, Hemant, Tong, Catherine, Tracy, Russell, Tsai, Michael, Vaidya, Dhananjay, Van Den Berg, David, VandeHaar, Peter, Vrieze, Scott, Walker, Tarik, Wallace, Robert, Walts, Avram, Wang, Fei Fei, Wang, Heming, Wang, Jiongming, Watson, Karol, Watt, Jennifer, Weeks, Daniel E., Weinstock, Joshua, Weir, Bruce, Weiss, Scott T, Weng, Lu-Chen, Wessel, Jennifer, Willer, Cristen, Williams, Kayleen, Williams, L. Keoki, Wilson, Carla, Wilson, James, Winterkorn, Lara, Wong, Quenna, Wu, Joseph, Xu, Huichun, Yanek, Lisa, Yang, Ivana, Yu, Ketian, Zekavat, Seyedeh Maryam, Zhang, Yingze, Zhao, Snow Xueyan, Zhao, Wei, Zhu, Xiaofeng, Ziv, Elad, Zody, Michael, Zoellner, Sebastian, Lindstrom, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rabecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, AlexandreTrégouët, David, Smith, Nicholas L., de Vries, Paul S., Reventun, Paula, Brown, Michael R., Heath, Adam S., Huffman, Jennifer E., Le, Ngoc-Quynh, Bebo, Allison, Temprano-Sagrera, Gerard, Raffield, Laura M., Ozel, Ayse Bilge, Thibord, Florian, Lewis, Joshua P., Rodriguez, Benjamin A. T., Polasek, Ozren, Yanek, Lisa R., Carrasquilla, German D., Marioni, Riccardo E., Kleber, Marcus E., Trégouët, David-Alexandre, Yao, Jie, Li-Gao, Ruifang, Joshi, Peter K., Trompet, Stella, Martinez-Perez, Angel, Ghanbari, Mohsen, Howard, Tom E., Reiner, Alex P., Arvanitis, Marios, Ryan, Kathleen A., Bartz, Traci M., Rudan, Igor, Faraday, Nauder, Linneberg, Allan, Davies, Gail, Delgado, Graciela E., Klaric, Lucija, Noordam, Raymond, van Rooij, Frank, Curran, Joanne E., Wheeler, Marsha M., Osburn, William O., O'Connell, Jeffrey R., Beswick, Andrew, Kolcic, Ivana, Souto, Juan Carlos, Becker, Lewis C., Hansen, Torben, Doyle, Margaret F., Harris, Sarah E., Moissl, Angela P., Rich, Stephen S., Campbell, Harry, Stott, David J., Soria, Jose Manuel, de Maat, Moniek P. M., Brody, Lawrence C., Auer, Paul L., Ben-Shlomo, Yoav, Hayward, Caroline, Mathias, Rasika A., Kilpeläinen, Tuomas O., Lange, Leslie A., Cox, Simon R., März, Winfried, Rotter, Jerome I., Mook-Kanamori, Dennis O., Wilson, James F., van der Harst, Pim, Jukema, J. Wouter, Ikram, M. Arfan, Desch, Karl C., Sabater-Lleal, Maria, Lowenstein, Charles J., and Morrison, Alanna C.
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- 2024
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7. A multitrait genetic study of hemostatic factors and hemorrhagic transformation after stroke treatment
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Dehghan, Abbas, Heath, Adam S., Morrison, Alanna C., Reiner, Alex P., Johnson, Andrew, Richmond, Anne, Peters, Annette, van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M., Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P., Tregouet, David A., Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W., Leebeek, Frank W.G., Rosendaal, Frits R., Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A., Bressler, Jan, Huffman, Jennifer E., Rotter, Jerome I., Yao, Jie, Wilson, James F., Bis, Joshua C., Hahn, Julie M., Desch, Karl C., Wiggins, Kerri L., Díez-Ahijado, Laia, Raffield, Laura M., Bielak, Lawrence F., Yanek, Lisa R., Kleber, Marcus E., Sabater-Lleal, Maria, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P., Liu, Melissa, Brown, Michael R., Jhun, Min-A, Chen, Ming-Huei, de Maat, Moniek P.M., Pankratz, Nathan, Smith, Nicholas L., Peyser, Patricia A., Elliot, Paul, de Vries, Paul S., Wei, Peng, Wild, Philipp S., Morange, Pierre E., van der Harst, Pim, Yang, Qiong, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M., Cox, Simon R., Trompet, Stella, Felix, Stephan B., Völker, Uwe, Tang, Weihong, Koenig, Wolfgang, Jukema, J. Wouter, Guo, Xiuqing, Gallego-Fabrega, Cristina, Temprano-Sagrera, Gerard, Cárcel-Márquez, Jara, Muiño, Elena, Cullell, Natalia, Lledós, Miquel, Llucià-Carol, Laia, Martin-Campos, Jesús M., Sobrino, Tomás, Castillo, José, Millán, Mònica, Muñoz-Narbona, Lucía, López-Cancio, Elena, Ribó, Marc, Alvarez-Sabin, Jose, Jiménez-Conde, Jordi, Roquer, Jaume, Tur, Silvia, Obach, Victor, Arenillas, Juan F., Segura, Tomas, Serrano-Heras, Gemma, Marti-Fabregas, Joan, Freijo-Guerrero, Marimar, Moniche, Francisco, Castellanos, Maria del Mar, and Fernández-Cadenas, Israel
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- 2024
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8. Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy
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Touw, Carolina E., Nemeth, Banne, van Adrichem, Raymond A., van Hylckama Vlieg, Astrid, Nelissen, Rob G. H. H., Lisman, Ton, and Cannegieter, Suzanne C.
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- 2023
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9. Association of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design
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Munsch, Gaëlle, Goumidi, Louisa, van Hylckama Vlieg, Astrid, Ibrahim-Kosta, Manal, Bruzelius, Maria, Deleuze, Jean-François, Rosendaal, Frits R., Jacqmin-Gadda, Hélène, Morange, Pierre-Emmanuel, and Trégouët, David-Alexandre
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- 2023
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10. Coagulation and inflammatory response after intramuscular or intradermal mRNA-1273 SARS-CoV-2 vaccine: secondary analysis of a randomized trial
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van Dijk, Willian J., Prins, Manon L.M., Roukens, Anna H.E., Roozen, Geert V.T., Roestenberg, Meta, Visser, Leo G., van Hylckama Vlieg, Astrid, and Rosendaal, Frits R.
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- 2024
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11. Incidence rate of venous thrombosis in women switching combined oral contraceptives: a cohort study
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Khialani, Deeksha, de Rooij, Esther, Szépligeti, Szimonetta Komjáthiné, Dudukina, Elena, le Cessie, Saskia, Ehrenstein, Vera, Rosendaal, Frits R., and van Hylckama Vlieg, Astrid
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- 2024
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12. Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
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Huffman, Jennifer E., Nicholas, Jayna, Hahn, Julie, Heath, Adam S., Raffield, Laura M., Yanek, Lisa R., Brody, Jennifer A., Thibord, Florian, Almasy, Laura, Bartz, Traci M., Bielak, Lawrence F., Bowler, Russell P., Carrasquilla, Germán D., Chasman, Daniel I., Chen, Ming-Huei, Emmert, David B., Ghanbari, Mohsen, Haessler, Jeffery, Hottenga, Jouke-Jan, Kleber, Marcus E., Le, Ngoc-Quynh, Lee, Jiwon, Lewis, Joshua P., Li-Gao, Ruifang, Luan, Jian'an, Malmberg, Anni, Mangino, Massimo, Marioni, Riccardo E., Martinez-Perez, Angel, Pankratz, Nathan, Polasek, Ozren, Richmond, Anne, Rodriguez, Benjamin A. T., Rotter, Jerome I., Steri, Maristella, Suchon, Pierre, Trompet, Stella, Weiss, Stefan, Zare, Marjan, Auer, Paul, Cho, Michael H., Christofidou, Paraskevi, Davies, Gail, de Geus, Eco, Deleuze, Jean-François, Delgado, Graciela E., Ekunwe, Lynette, Faraday, Nauder, Gögele, Martin, Greinacher, Andreas, He, Gao, Howard, Tom, Joshi, Peter K., Kilpeläinen, Tuomas O., Lahti, Jari, Linneberg, Allan, Naitza, Silvia, Noordam, Raymond, Paüls-Vergés, Ferran, Rich, Stephen S., Rosendaal, Frits R., Rudan, Igor, Ryan, Kathleen A., Souto, Juan Carlos, van Rooij, Frank J. A., Wang, Heming, Zhao, Wei, Becker, Lewis C., Beswick, Andrew, Brown, Michael R., Cade, Brian E., Campbell, Harry, Cho, Kelly, Crapo, James D., Curran, Joanne E., de Maat, Moniek P. M., Doyle, Margaret, Elliott, Paul, Floyd, James S., Fuchsberger, Christian, Grarup, Niels, Guo, Xiuqing, Harris, Sarah E., Hou, Lifang, Kolcic, Ivana, Kooperberg, Charles, Menni, Cristina, Nauck, Matthias, O'Connell, Jeffrey R., Orrù, Valeria, Psaty, Bruce M., Räikkönen, Katri, Smith, Jennifer A., Soria, Jose Manuel, Stott, David J., van Hylckama Vlieg, Astrid, Watkins, Hugh, Willemsen, Gonneke, Wilson, Peter W. F., Ben-Shlomo, Yoav, Blangero, John, Boomsma, Dorret, Cox, Simon R., Dehghan, Abbas, Eriksson, Johan G., Fiorillo, Edoardo, Fornage, Myriam, Hansen, Torben, Hayward, Caroline, Ikram, M. Arfan, Jukema, J. Wouter, Kardia, Sharon L. R., Lange, Leslie A., März, Winfried, Mathias, Rasika A., Mitchell, Braxton D., Mook-Kanamori, Dennis O., Morange, Pierre-Emmanuel, Pedersen, Oluf, Pramstaller, Peter P., Redline, Susan, Reiner, Alexander, Ridker, Paul M., Silverman, Edwin K., Spector, Tim D., Völker, Uwe, Wareham, Nick, Wilson, James F., Yao, Jie, Trégouët, David-Alexandre, Johnson, Andrew D., Wolberg, Alisa S., de Vries, Paul S., Sabater-Lleal, Maria, Morrison, Alanna C., and Smith, Nicholas L.
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- 2024
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13. Genomic science of risk prediction for venous thromboembolic disease: convenient clarification or compounding complexity
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Han, Jihee, van Hylckama Vlieg, Astrid, and Rosendaal, Frits R.
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- 2023
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14. Plasma levels of coagulation factors VIII and IX and risk of venous thromboembolism: Systematic review and meta-analysis
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Lowe, Gordon, Wu, Olivia, van Hylckama Vlieg, Astrid, Folsom, Aaron, Rosendaal, Frits, and Woodward, Mark
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- 2023
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15. Sex-specific association between microvascular health and coagulation parameters: the Netherlands Epidemiology of Obesity study
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Yuan, Lushun, Han, Jihee, van der Velden, Anouk I.M., Vink, Hans, de Mutsert, Renée, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Li-Gao, Ruifang, Rabelink, Ton J., and van den Berg, Bernard M.
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- 2023
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16. Health-related quality of life after first venous thromboembolism in individuals aged 70 years and older
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Wang, Huijie, Klok, Frederikus A., Rosendaal, Frits R., Cushman, Mary, and van Hylckama Vlieg, Astrid
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- 2023
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17. Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial
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Aardenburg-van Huisstede, Astrid, Ammerlaan, Heidi S.M., Boersma, Willem G., Bonten, Marc J.M., van den Bosch, Maurice A.A.J., Brinkman, Kees, Bruijning-Verhagen, Patricia C.J., van Crevel, Reinout, Delsing, Corine, ten Doesschaten, Thijs, Dofferhoff, Anton S.M., Duijkers, Ruud, Fohse, Konstantin, Grobusch, Martin P., Groenwold, Rolf H.H., de Haas, Corine, Hassing, Robert-Jan, de Hoog, Marieke L.A., Hoogerwerf, Jacobien J., Huijts, Susanne M., van Hylckama-Vlieg, Astrid, Jong, Eefje, de Jong, Hanna K., Knap, Martijn, Koekenbier, Eva L., Koenders, Michael, Kouijzer, Ilse J.E., Kramer, Henk, van de Laar, Roel, Lalmohamed, Arief, Lensen, Karel-Jan D.F., Lijfering, Willem M., van de Maat, Josephine S., Magdelijns, Fabienne, Meek, Bob, Middelburg, Rutger A., Moeniralam, Hazra S., Mooijaart, Simon P., van Munster, Barbara C., Netea, Mihai G., van Nieuwkoop, Cees, ten Oever, Jaap, Oosterheert, Jan Jelrik, Goossens, Marc Padros, Peters, Vincent, Postma, Douwe F., Pouw, Niels, Reesink, Herre J., de Regt, Marieke J.A., van der Reijden, Anneli C.J., Rosendaal, Frits R., Schaakxs, R., Slieker, Kitty, Slingerland, Robbert J., van Sluis, Nicolette L.J., Stehouwer, Coen D.A., van de Veerdonk, Frank, Verbon, Annelies, van Werkhoven, C.H. (Henri), van de Wijgert, Janneke H.H., and Werkhoven, C.H. (Henri) van
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- 2023
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18. Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels
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Sabater-Lleal, Maria, Huffman, Jennifer E, de Vries, Paul S, Marten, Jonathan, Mastrangelo, Michael A, Song, Ci, Pankratz, Nathan, Ward-Caviness, Cavin K, Yanek, Lisa R, Trompet, Stella, Delgado, Graciela E, Guo, Xiuqing, Bartz, Traci M, Martinez-Perez, Angel, Germain, Marine, de Haan, Hugoline G, Ozel, Ayse B, Polasek, Ozren, Smith, Albert V, Eicher, John D, Reiner, Alex P, Tang, Weihong, Davies, Neil M, Stott, David J, Rotter, Jerome I, Tofler, Geoffrey H, Boerwinkle, Eric, de Maat, Moniek PM, Kleber, Marcus E, Welsh, Paul, Brody, Jennifer A, Chen, Ming-Huei, Vaidya, Dhananjay, Soria, José Manuel, Suchon, Pierre, van Hylckama Vlieg, Astrid, Desch, Karl C, Kolcic, Ivana, Joshi, Peter K, Launer, Lenore J, Harris, Tamara B, Campbell, Harry, Rudan, Igor, Becker, Diane M, Li, Jun Z, Rivadeneira, Fernando, Uitterlinden, André G, Hofman, Albert, Franco, Oscar H, Cushman, Mary, Psaty, Bruce M, Morange, Pierre-Emmanuel, McKnight, Barbara, Chong, Michael R, Fernandez-Cadenas, Israel, Rosand, Jonathan, Lindgren, Arne, Consortium, INVENT Consortium MEGASTROKE Consortium of the International Stroke Genetics, Gudnason, Vilmundur, Wilson, James F, Hayward, Caroline, Ginsburg, David, Fornage, Myriam, Rosendaal, Frits R, Souto, Juan Carlos, Becker, Lewis C, Jenny, Nancy S, März, Winfried, Jukema, J Wouter, Dehghan, Abbas, Trégouët, David-Alexandre, Morrison, Alanna C, Johnson, Andrew D, O’Donnell, Christopher J, Strachan, David P, Lowenstein, Charles J, and Smith, Nicholas L
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Epidemiology ,Health Sciences ,Hematology ,Biotechnology ,Rare Diseases ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Blood ,Cardiovascular ,Arterial Occlusive Diseases ,Biomarkers ,Blood Coagulation ,Blood Coagulation Disorders ,Inherited ,Factor VIII ,Genetic Loci ,Genetic Markers ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Humans ,Mendelian Randomization Analysis ,Phenotype ,Ribosomal Protein L3 ,Risk Factors ,Venous Thrombosis ,von Willebrand Factor ,cardiovascular diseases ,factor VIII ,genome-wide association studies ,genetics ,risk factors ,von Willebrand factor ,INVENT Consortium ,MEGASTROKE Consortium of the International Stroke Genetics Consortium ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology ,Clinical sciences ,Sports science and exercise - Abstract
BackgroundFactor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF.MethodsWe meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. All studies performed linear regression analysis using an additive genetic model and associated ≈35 million imputed variants with natural log-transformed phenotype levels. In vitro gene silencing in cultured endothelial cells was performed for candidate genes to provide additional evidence on association and function. Two-sample Mendelian randomization analyses were applied to test the causal role of FVIII and VWF plasma levels on the risk of arterial and venous thrombotic events.ResultsWe identified 13 novel genome-wide significant ( P≤2.5×10-8) associations, 7 with FVIII levels ( FCHO2/TMEM171/TNPO1, HLA, SOX17/RP1, LINC00583/NFIB, RAB5C-KAT2A, RPL3/TAB1/SYNGR1, and ARSA) and 11 with VWF levels ( PDHB/PXK/KCTD6, SLC39A8, FCHO2/TMEM171/TNPO1, HLA, GIMAP7/GIMAP4, OR13C5/NIPSNAP, DAB2IP, C2CD4B, RAB5C-KAT2A, TAB1/SYNGR1, and ARSA), beyond 10 previously reported associations with these phenotypes. Functional validation provided further evidence of association for all loci on VWF except ARSA and DAB2IP. Mendelian randomization suggested causal effects of plasma FVIII activity levels on venous thrombosis and coronary artery disease risk and plasma VWF levels on ischemic stroke risk.ConclusionsThe meta-analysis identified 13 novel genetic loci regulating FVIII and VWF plasma levels, 10 of which we validated functionally. We provide some evidence for a causal role of these proteins in thrombotic events.
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- 2019
19. Association between cardiovascular risk factors and venous thromboembolism in the elderly
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Wang, Huijie, Rosendaal, Frits R., Cushman, Mary, and van Hylckama Vlieg, Astrid
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- 2022
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20. Association between venous thromboembolism‐associated genetic variants, coagulation factor levels, and thrombin generation potential
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Han, Jihee, primary, Li‐Gao, Ruifang, additional, de Mutsert, Renée, additional, Rosendaal, Frits R., additional, and van Hylckama Vlieg, Astrid, additional
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- 2024
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21. A genetic association study of circulating coagulation Factor VIII and von Willebrand Factor levels
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de Vries, Paul S., primary, Reventun, Paula, additional, Brown, Michael R, additional, Heath, Adam S, additional, Huffman, Jennifer E., additional, Le, Ngoc-Quynh, additional, Bebo, Allison, additional, Brody, Jennifer A, additional, Temprano-Sagrera, Gerard, additional, Raffield, Laura M, additional, Ozel, Ayse Bilge, additional, Thibord, Florian, additional, Jain, Deepti, additional, Lewis, Joshua P, additional, Rodriguez, Benjamin A.T., additional, Pankratz, Nathan, additional, Taylor, Kent D, additional, Polasek, Ozren, additional, Chen, Ming-Huei, additional, Yanek, Lisa R, additional, Carrasquilla, German, additional, Marioni, Riccardo, additional, Kleber, Marcus E, additional, Trégouët, David-Alexandre, additional, Yao, Jie, additional, Li-Gao, Ruifang, additional, Joshi, Peter K, additional, Trompet, Stella, additional, Martinez-Perez, Angel, additional, Ghanbari, Mohsen, additional, Howard, Tom E., additional, Reiner, Alex P, additional, Arvanitis, Marios, additional, Ryan, Kathleen A, additional, Bartz, Traci M, additional, Rudan, Igor, additional, Faraday, Nauder, additional, Linneberg, Allan, additional, Ekunwe, Lynette, additional, Davies, Gail, additional, Delgado, Graciela E, additional, Suchon, Pierre, additional, Guo, Xiuqing, additional, Rosendaal, Frits R., additional, Klaric, Lucija, additional, Noordam, Raymond, additional, van Rooij, Frank J.A., additional, Curran, Joanne, additional, Wheeler, Marsha Maria, additional, Osburn, William O, additional, O'Connell, Jeffrey R, additional, Boerwinkle, Eric, additional, Beswick, Andrew, additional, Psaty, Bruce M., additional, Kolcic, Ivana, additional, Souto, Juan Carlos Carlos, additional, Becker, Lewis, additional, Hansen, Torben, additional, Doyle, Margaret F., additional, Harris, Sarah, additional, Moissl, Angela Patricia, additional, Deleuze, Jean-François, additional, Rich, Stephen S, additional, van Hylckama Vlieg, Astrid, additional, Campbell, Harry, additional, Stott, David, additional, Soria, Jose Manuel, additional, de Maat, Moniek P.M., additional, Almasy, Laura, additional, Brody, Lawrence C., additional, Auer, Paul, additional, Mitchell, Braxton D, additional, Ben-Shlomo, Yoav, additional, Fornage, Myriam, additional, Hayward, Caroline, additional, Mathias, Rasika, additional, Kilpeläinen, Tuomas O, additional, Lange, Leslie, additional, Cox, Simon R, additional, Maerz, Winfried, additional, Morange, Pierre-Emmanuel, additional, Rotter, Jerome I, additional, Mook-Kanamori, Dennis O, additional, Wilson, James, additional, van der Harst, Pim, additional, Jukema, Johan Wouter W., additional, Ikram, Mohammad Arfan, additional, Blangero, John, additional, Kooperberg, Charles, additional, Desch, Karl, additional, Johnson, Andrew D., additional, Sabater-Lleal, Maria, additional, Lowenstein, Charles, additional, Smith, Nicholas L., additional, and Morrison, Alanna, additional
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- 2024
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22. D‐dimer, thrombin generation, and risk of a first venous thrombosis in the elderly
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Wang, Huijie, Rosendaal, Frits R., Cushman, Mary, and van Hylckama Vlieg, Astrid
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- 2021
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23. Venous thrombosis with oral postmenopausal hormone therapy: Roles of activated protein C resistance and tissue factor pathway inhibitor
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Khialani, Deeksha, Vasan, Sowmya, Cushman, Mary, Dahm, Anders Erik Astrup, Sandset, Per Morten, Rossouw, Jacques, and van Hylckama Vlieg, Astrid
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- 2021
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24. Procoagulant factor levels and risk of venous thrombosis in the elderly
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Wang, Huijie, Rosendaal, Frits R., Cushman, Mary, and van Hylckama Vlieg, Astrid
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- 2021
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25. Increasing levels of von Willebrand factor and factor VIII with age in patients affected by von Willebrand disease
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Biguzzi, Eugenia, Siboni, Simona Maria, le Cessie, Saskia, Baronciani, Luciano, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, and Peyvandi, Flora
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- 2021
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26. Combined hormonal contraceptive use in Europe before and after the European Commission mandated changes in product information
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Khialani, Deeksha, Jones, Mary Elizabeth, Szépligeti, Szimonetta Komjáthiné, Ording, Anne Gulbech, Ehrenstein, Vera, Petersen, Irene, and van Hylckama Vlieg, Astrid
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- 2020
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27. Per- and polyfluoroalkyl substances concentrations are associated with an unfavorable cardio-metabolic risk profile: findings from two population-based cohort studies
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Faquih, Tariq O., primary, Landstra, Elvire N., additional, van Hylckama Vlieg, Astrid, additional, Aziz, N.Ahmad, additional, Li-Gao, Ruifang, additional, de Mutsert, Renée, additional, Rosendaal, Frits R., additional, Noordam, Raymond, additional, van Heemst, Diana, additional, Mook-Kanamori, Dennis O., additional, Willems van Dijk, Ko, additional, and Breteler, Monique M.B., additional
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- 2023
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28. Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism
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Lindström, Sara, Wang, Lu, Smith, Erin N., Gordon, William, van Hylckama Vlieg, Astrid, de Andrade, Mariza, Brody, Jennifer A., Pattee, Jack W., Haessler, Jeffrey, Brumpton, Ben M., Chasman, Daniel I., Suchon, Pierre, Chen, Ming-Huei, Turman, Constance, Germain, Marine, Wiggins, Kerri L., MacDonald, James, Braekkan, Sigrid K., Armasu, Sebastian M., Pankratz, Nathan, Jackson, Rebecca D., Nielsen, Jonas B., Giulianini, Franco, Puurunen, Marja K., Ibrahim, Manal, Heckbert, Susan R., Damrauer, Scott M., Natarajan, Pradeep, Klarin, Derek, de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Bammler, Theo K., Frazer, Kelly A., McCauley, Bryan M., Taylor, Kent, Pankow, James S., Reiner, Alexander P., Gabrielsen, Maiken E., Deleuze, Jean-François, O'Donnell, Chris J., Kim, Jihye, McKnight, Barbara, Kraft, Peter, Hansen, John-Bjarne, Rosendaal, Frits R., Heit, John A., Psaty, Bruce M., Tang, Weihong, Kooperberg, Charles, Hveem, Kristian, Ridker, Paul M., Morange, Pierre-Emmanuel, Johnson, Andrew D., Kabrhel, Christopher, Trégouët, David-Alexandre, and Smith, Nicholas L.
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- 2019
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29. Glucose metabolism affects coagulation factors: The NEO study
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van der Toorn, Fréderique A., de Mutsert, Renée, Lijfering, Willem M., Rosendaal, Frits R., and van Hylckama Vlieg, Astrid
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- 2019
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30. SMIM1 absence is associated with reduced energy expenditure and excess weight
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Banasik, Karina, Bay, Jakob, Boldsen, Jens Kjærgaard, Brodersen, Thorsten, Brunak, Søren, Burgdorf, Kristoffer, Chalmer, Mona Ameri, Didriksen, Maria, Dinh, Khoa Manh, Dowsett, Joseph, Erikstrup, Christian, Feenstra, Bjarke, Geller, Frank, Gudbjartsson, Daniel, Hansen, Thomas Folkmann, Hindhede, Lotte, Hjalgrim, Henrik, Jacobsen, Rikke Louise, Jemec, Gregor, Jensen, Bitten Aagaard, Kaspersen, Katrine, Kjerulff, Bertram Dalskov, Kogelman, Lisette, Hørup Larsen, Margit Anita, Louloudis, Ioannis, Lundgaard, Agnete, Susan, Mikkelsen, Christina, Nissen, Ioanna, Nyegaard, Mette, Ostrowski, Sisse Rye, Pedersen, Ole Birger, Henriksen, Alexander Pil, Rohde, Palle Duun, Rostgaard, Klaus, Schwinn, Michael, Stefansson, Kari, Stefánsson, Hreinn, Sørensen, Erik, þorsteinsdóttir, Unnur, Thørner, Lise Wegner, Bruun, Mie Topholm, Ullum, Henrik, Werge, Thomas, Westergaard, David, Chen, Ji, Spracklen, Cassandra N., Marenne, Gaëlle, Varshney, Arushi, Corbin, Laura J., Luan, Jian’an, Willems, Sara M., Wu, Ying, Zhang, Xiaoshuai, Horikoshi, Momoko, Boutin, Thibaud S., Mägi, Reedik, Waage, Johannes, Li-Gao, Ruifang, Katie Chan, Kei Hang, Yao, Jie, Anasanti, Mila D., Chu, Audrey Y., Claringbould, Annique, Heikkinen, Jani, Hong, Jaeyoung, Hottenga, Jouke-Jan, Huo, Shaofeng, Kaakinen, Marika A., Louie, Tin, März, Winfried, Moreno-Macias, Hortensia, Ndungu, Anne, Nelson, Sarah C., Nolte, Ilja M., North, Kari E., Raulerson, Chelsea K., Ray, Debashree, Rohde, Rebecca, Rybin, Denis, Schurmann, Claudia, Sim, Xueling, Southam, Loz, Stewart, Isobel D., Wang, Carol A., Wang, Yujie, Wu, Peitao, Zhang, Weihua, Ahluwalia, Tarunveer S., Appel, Emil V.R., Bielak, Lawrence F., Brody, Jennifer A., Burtt, Noël P., Cabrera, Claudia P., Cade, Brian E., Chai, Jin Fang, Chai, Xiaoran, Chang, Li-Ching, Chen, Chien-Hsiun, Chen, Brian H., Chitrala, Kumaraswamy Naidu, Chiu, Yen-Feng, de Haan, Hugoline G., Delgado, Graciela E., Demirkan, Ayse, Duan, Qing, Engmann, Jorgen, Fatumo, Segun A., Gayán, Javier, Giulianini, Franco, Gong, Jung Ho, Gustafsson, Stefan, Hai, Yang, Hartwig, Fernando P., He, Jing, Heianza, Yoriko, Huang, Tao, Huerta-Chagoya, Alicia, Hwang, Mi Yeong, Jensen, Richard A., Kawaguchi, Takahisa, Kentistou, Katherine A., Kim, Young Jin, Kleber, Marcus E., Kooner, Ishminder K., Lai, Shuiqing, Lange, Leslie A., Langefeld, Carl D., Lauzon, Marie, Li, Man, Ligthart, Symen, Liu, Jun, Loh, Marie, Long, Jirong, Lyssenko, Valeriya, Mangino, Massimo, Marzi, Carola, Montasser, May E., Nag, Abhishek, Nakatochi, Masahiro, Noce, Damia, Noordam, Raymond, Pistis, Giorgio, Preuss, Michael, Raffield, Laura, Rasmussen-Torvik, Laura J., Rich, Stephen S., Robertson, Neil R., Rueedi, Rico, Ryan, Kathleen, Sanna, Serena, Saxena, Richa, Schraut, Katharina E., Sennblad, Bengt, Setoh, Kazuya, Smith, Albert V., Southam, Lorraine, Sparsø, Thomas, Strawbridge, Rona J., Takeuchi, Fumihiko, Tan, Jingyi, Trompet, Stella, van den Akker, Erik, van der Most, Peter J., Verweij, Niek, Vogel, Mandy, Wang, Heming, Wang, Chaolong, Wang, Nan, Warren, Helen R., Wen, Wanqing, Wilsgaard, Tom, Wong, Andrew, Wood, Andrew R., Xie, Tian, Zafarmand, Mohammad Hadi, Zhao, Jing-Hua, Zhao, Wei, Amin, Najaf, Arzumanyan, Zorayr, Astrup, Arne, Bakker, Stephan J.L., Baldassarre, Damiano, Beekman, Marian, Bergman, Richard N., Bertoni, Alain, Blüher, Matthias, Bonnycastle, Lori L., Bornstein, Stefan R., Bowden, Donald W., Cai, Qiuyin, Campbell, Archie, Campbell, Harry, Chang, Yi Cheng, de Geus, Eco J.C., Dehghan, Abbas, Du, Shufa, Eiriksdottir, Gudny, Farmaki, Aliki Eleni, Frånberg, Mattias, Fuchsberger, Christian, Gao, Yutang, Gjesing, Anette P., Goel, Anuj, Han, Sohee, Hartman, Catharina A., Herder, Christian, Hicks, Andrew A., Hsieh, Chang-Hsun, Hsueh, Willa A., Ichihara, Sahoko, Igase, Michiya, Ikram, M. Arfan, Johnson, W. Craig, Jørgensen, Marit E., Joshi, Peter K., Kalyani, Rita R., Kandeel, Fouad R., Katsuya, Tomohiro, Khor, Chiea Chuen, Kiess, Wieland, Kolcic, Ivana, Kuulasmaa, Teemu, Kuusisto, Johanna, Läll, Kristi, Lam, Kelvin, Lawlor, Deborah A., Lee, Nanette R., Lemaitre, Rozenn N., Li, Honglan, Lin, Shih-Yi, Lindström, Jaana, Linneberg, Allan, Liu, Jianjun, Lorenzo, Carlos, Matsubara, Tatsuaki, Matsuda, Fumihiko, Mingrone, Geltrude, Mooijaart, Simon, Moon, Sanghoon, Nabika, Toru, Nadkarni, Girish N., Nadler, Jerry L., Nelis, Mari, Neville, Matt J., Norris, Jill M., Ohyagi, Yasumasa, Peters, Annette, Peyser, Patricia A., Polasek, Ozren, Qi, Qibin, Raven, Dennis, Reilly, Dermot F., Reiner, Alex, Rivideneira, Fernando, Roll, Kathryn, Rudan, Igor, Sabanayagam, Charumathi, Sandow, Kevin, Sattar, Naveed, Schürmann, Annette, Shi, Jinxiu, Stringham, Heather M., Taylor, Kent D., Teslovich, Tanya M., Thuesen, Betina, Timmers, Paul R.H.J., Tremoli, Elena, Tsai, Michael Y., Uitterlinden, Andre, van Dam, Rob M., van Heemst, Diana, van Hylckama Vlieg, Astrid, Van Vliet-Ostaptchouk, Jana V., Vangipurapu, Jagadish, Vestergaard, Henrik, Wang, Tao, Willems van Dijk, Ko, Zemunik, Tatijana, Abecasis, Goncalo R., Adair, Linda S., Aguilar-Salinas, Carlos Alberto, Alarcón-Riquelme, Marta E., An, Ping, Aviles-Santa, Larissa, Becker, Diane M., Beilin, Lawrence J., Bergmann, Sven, Bisgaard, Hans, Black, Corri, Boehnke, Michael, Boerwinkle, Eric, Böhm, Bernhard O., Bønnelykke, Klaus, Boomsma, D.I., Bottinger, Erwin P., Buchanan, Thomas A., Canouil, Mickaël, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Ida Chen, Yii-Der, Cheng, Ching-Yu, Collins, Francis S., Correa, Adolfo, Cucca, Francesco, Janaka de Silva, H., Dedoussis, George, Elmståhl, Sölve, Evans, Michele K., Ferrannini, Ele, Ferrucci, Luigi, Florez, Jose C., Franks, Paul W., Frayling, Timothy M., Froguel, Philippe, Gigante, Bruna, Goodarzi, Mark O., Gordon-Larsen, Penny, Grallert, Harald, Grarup, Niels, Grimsgaard, Sameline, Groop, Leif, Gudnason, Vilmundur, Guo, Xiuqing, Hamsten, Anders, Hansen, Torben, Hayward, Caroline, Heckbert, Susan R., Horta, Bernardo L., Huang, Wei, Ingelsson, Erik, James, Pankow S., Jarvelin, Marjo-Ritta, Jonas, Jost B., Jukema, J. Wouter, Kaleebu, Pontiano, Kaplan, Robert, Kardia, Sharon L.R., Kato, Norihiro, Keinanen-Kiukaanniemi, Sirkka M., Kim, Bong-Jo, Kivimaki, Mika, Koistinen, Heikki A., Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kuh, Diana, Kumari, Meena, Kutalik, Zoltan, Laakso, Markku, Lakka, Timo A., Launer, Lenore J., Leander, Karin, Li, Huaixing, Lin, Xu, Lind, Lars, Lindgren, Cecilia, Liu, Simin, Loos, Ruth J.F., Magnusson, Patrik K.E., Mahajan, Anubha, Metspalu, Andres, Mook-Kanamori, Dennis O., Mori, Trevor A., Munroe, Patricia B., Njølstad, Inger, O'Connell, Jeffrey R., Oldehinkel, Albertine J., Ong, Ken K., Padmanabhan, Sandosh, Palmer, Colin N.A., Palmer, Nicholette D., Pedersen, Oluf, Pennell, Craig E., Porteous, David J., Pramstaller, Peter P., Province, Michael A., Psaty, Bruce M., Qi, Lu, Raffel, Leslie J., Rauramaa, Rainer, Redline, Susan, Ridker, Paul M., Rosendaal, Frits R., Saaristo, Timo E., Sandhu, Manjinder, Saramies, Jouko, Schneiderman, Neil, Schwarz, Peter, Scott, Laura J., Selvin, Elizabeth, Sever, Peter, Shu, Xiao-Ou, Slagboom, P. Eline, Small, Kerrin S., Smith, Blair H., Snieder, Harold, Sofer, Tamar, Sørensen, Thorkild I.A., Spector, Tim D., Stanton, Alice, Steves, Claire J., Stumvoll, Michael, Sun, Liang, Tabara, Yasuharu, Tai, E. Shyong, Timpson, Nicholas J., Tönjes, Anke, Tuomilehto, Jaakko, Tusie, Teresa, Uusitupa, Matti, van der Harst, Pim, van Duijn, Cornelia, Vitart, Veronique, Vollenweider, Peter, Vrijkotte, Tanja G.M., Wagenknecht, Lynne E., Walker, Mark, Wang, Ya X., Wareham, Nick J., Watanabe, Richard M., Watkins, Hugh, Wei, Wen B., Wickremasinghe, Ananda R., Willemsen, Gonneke, Wilson, James F., Wong, Tien-Yin, Wu, Jer-Yuarn, Xiang, Anny H., Yanek, Lisa R., Yengo, Loïc, Yokota, Mitsuhiro, Zeggini, Eleftheria, Zheng, Wei, Zonderman, Alan B., Rotter, Jerome I., Gloyn, Anna L., McCarthy, Mark I., Dupuis, Josée, Meigs, James B., Scott, Robert A., Prokopenko, Inga, Leong, Aaron, Liu, Ching-Ti, Parker, Stephen C.J., Mohlke, Karen L., Langenberg, Claudia, Wheeler, Eleanor, Morris, Andrew P., Barroso, Inês, Stefanucci, Luca, Moslemi, Camous, Tomé, Ana R., Virtue, Samuel, Bidault, Guillaume, Gleadall, Nicholas S., Watson, Laura P.E., Kwa, Jing E., Burden, Frances, Farrow, Samantha, Võsa, Urmo, Burling, Keith, Walker, Lindsay, Ord, John, Barker, Peter, Warner, James, Frary, Amy, Renhstrom, Karola, Ashford, Sofie E., Piper, Jo, Biggs, Gail, Erber, Wendy N., Hoffman, Gary J., Schoenmakers, Nadia, Rieneck, Klaus, Dziegiel, Morten H., Azzu, Vian, Vacca, Michele, Aparicio, Hugo Javier, Hui, Qin, Cho, Kelly, Sun, Yan V., Wilson, Peter W., Bayraktar, Omer A., Vidal-Puig, Antonio, Ostrowski, Sisse R., Astle, William J., Olsson, Martin L., Storry, Jill R., Pedersen, Ole B., Ouwehand, Willem H., Chatterjee, Krishna, Vuckovic, Dragana, and Frontini, Mattia
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- 2024
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31. The association of genetic variants in the cholesteryl ester transfer protein gene with hemostatic factors and a first venous thrombosis
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Li‐Gao, Ruifang, Mook‐Kanamori, Dennis O., Cannegieter, Suzanne C., Willems van Dijk, Ko, Rosendaal, Frits R., and van Hylckama Vlieg, Astrid
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- 2019
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32. Endogenous sex hormones and risk of venous thromboembolism in young women
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Scheres, Luuk J.J., van Hylckama Vlieg, Astrid, Ballieux, Bart E.P.B., Fauser, Bart C.J.M., Rosendaal, Frits R., Middeldorp, Saskia, and Cannegieter, Suzanne C.
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- 2019
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33. A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology
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de Vries, Paul S., Sabater-Lleal, Maria, Huffman, Jennifer E., Marten, Jonathan, Song, Ci, Pankratz, Nathan, Bartz, Traci M., de Haan, Hugoline G., Delgado, Graciela E., Eicher, John D., Martinez-Perez, Angel, Ward-Caviness, Cavin K., Brody, Jennifer A., Chen, Ming-Huei, de Maat, Moniek P.M., Frånberg, Mattias, Gill, Dipender, Kleber, Marcus E., Rivadeneira, Fernando, Soria, José Manuel, Tang, Weihong, Tofler, Geoffrey H., Uitterlinden, André G., van Hylckama Vlieg, Astrid, Seshadri, Sudha, Boerwinkle, Eric, Davies, Neil M., Giese, Anne-Katrin, Ikram, M. Kamran, Kittner, Steven J., McKnight, Barbara, Psaty, Bruce M., Reiner, Alex P., Sargurupremraj, Muralidharan, Taylor, Kent D., Fornage, Myriam, Hamsten, Anders, März, Winfried, Rosendaal, Frits R., Souto, Juan Carlos, Dehghan, Abbas, Johnson, Andrew D., Morrison, Alanna C., O’Donnell, Christopher J., and Smith, Nicholas L.
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- 2019
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34. Rosuvastatin use reduces thrombin generation potential in patients with venous thromboembolism: a randomized controlled trial
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Orsi, Fernanda A., Biedermann, Joseph S., Kruip, Marieke J.H.A., van der Meer, Felix J., Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Bos, Mettine H.A., Leebeek, Frank W.G., Cannegieter, Suzanne C., and Lijfering, Willem M.
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- 2019
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35. Association Between Hepatic Triglyceride Content and Coagulation Factors: The Netherlands Epidemiology of Obesity Study
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Morelli, Vânia M., de Mutsert, Renée, de Roos, Albert, Lamb, Hildo J., van Hylckama Vlieg, Astrid, Bos, Mettine H.A., Rosendaal, Frits R., Lijfering, Willem M., and Cannegieter, Suzanne C.
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- 2020
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36. CD36 regulates factor VIII secretion from liver endothelial cells
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Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Jukema, Wouter, Trompet, Stella, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Chasman, Daniel, Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Wolberg, Alisa S., de Vries, Paul S., Osburn, William O., Arvanitis, Marios, and Lowenstein, Charles J.
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- 2024
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37. Robust metabolomic age prediction based on a wide selection of metabolites
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Faquih, Tariq, primary, van Hylckama Vlieg, Astrid, additional, Surendran, Praveen, additional, Butterworth, Adam S., additional, Li-Gao, Ruifang, additional, de Mutsert, Renée, additional, Rosendaa, Frits R., additional, Noordam, Raymond, additional, van Heemst, Diana, additional, van Dijk, Ko Willems, additional, and Mook-Kanamori, Dennis O., additional
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- 2023
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38. Hepatic triglyceride content is intricately associated with numerous metabolites and biochemical pathways
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Faquih, Tariq O., primary, van Klinken, Jan Bert, additional, Li‐Gao, Ruifang, additional, Noordam, Raymond, additional, van Heemst, Diana, additional, Boone, Sebastiaan, additional, Sheridan, Patricia A., additional, Michelotti, Gregory, additional, Lamb, Hildo, additional, de Mutsert, Renée, additional, Rosendaal, Frits R., additional, van Hylckama Vlieg, Astrid, additional, van Dijk, Ko Willems, additional, and Mook‐Kanamori, Dennis O., additional
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- 2023
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39. CD36 regulates factor VIII secretion from liver endothelial cells
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Reventun, Paula, Toledano-Sanz, Pablo, Alcharani, Nunzio, Viskadourou, Maria, Morrison, Alanna C., Sabater-Lleal, Maria, Wolberg, Alisa S., de Vries, Paul S., Smith, Nicholas L., Osburn, William O., Arvanitis, Marios, Lowenstein, Charles J., Dehghan, Abbas, Gill, Dipender, Elliot, Paul, Pankratz, Nathan, Tang, Weihong, Wei, Peng, deVries, Paul, Brown, Michael, Bressler, Jan, Hahn, Julie, Friedman, Rachel K., Heath, Adam, Morrison, Alanna, Strachan, David, Reiner, Alex P., Conomos, Matt, Psaty, Bruce M., Brody, Jen, Bis, Joshua C., Wiggins, Kerri L., Smith, Nicholas L., Hayward, Caroline, Richmond, Anne, O’Donnell, Chris, Huffman, Jenny, Chen, Ming-Huei, Yang, Qiong, Thibord, Florian, Liu, Melissa, Johnson, Andrew, Desch, Karl, Sabater-Lleal, Maria, Temprano, Gerard, Díez, Laia, Yanek, Lisa, Peyser, Patricia, Jhun, Mina, Wild, Philipp, Reiner, Alex, Raffield, Laura, Taylor, Herman, Nicholas, Jayna, Youkhana, Kim, Peters, Annette, Mueller, Martina, Ward-Caviness, Cavin, Koenig, Wolfgang, Cox, Simon, Davies, Gail, Marioni, Riccardo, Kleber, Marcus, Tregouet, David, Morange, Pierre, Rosendaal, Frits R., van Hylckama Vlieg, Astrid, Rotter, Jerry, Yao, Jie, Guo, Xiuqing, O’Donnell, Chris, Damrauer, Scott, Li, Ruifang, Mook, Dennis, Rosendaal, Frits R., Campbell, Harry, van der Harst, Pim, Asselbergs, Folkert, Sabater-Lleal, Maria, Jukema, Wouter, Trompet, Stella, Sabater-Lleal, Maria, Kavousi, Maryam, Leebeek, Frank, de Maat, Moniek, Felix, Stephan, Voelker, Uwe, Homuth, Georg, Mangino, Massimo, Reiner, Alex P., and Chasman, Daniel
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- 2024
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40. Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk
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Stegeman, Bernardine H., Vos, Hans L., Helmerhorst, Frans M., Rosendaal, Frits R., Reitsma, Pieter H., and van Hylckama Vlieg, Astrid
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- 2017
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41. Statin use and risk of recurrent venous thrombosis: results from the MEGA follow‐up study
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Brækkan, Sigrid K., Caram‐Deelder, Camila, Siegerink, Bob, van Hylckama Vlieg, Astrid, le Cessie, Saskia, Rosendaal, Frits R., Cannegieter, Suzanne C., and Lijfering, Willem M.
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- 2017
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42. Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles
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Huffman, Jennifer E, Nicolas, Jayna, Hahn, Julie, Heath, Adam S, Raffield, Laura M, Yanek, Lisa R, Brody, Jennifer A, Thibord, Florian, Almasy, Laura, Bartz, Traci M, Bielak, Lawrence F., Bowler, Russell P, Carrasquilla, Germán D, Chasman, Daniel I, Chen, Ming-Huei, Emmert, David B, Ghanbari, Mohsen, Haessle, Jeffery, Hottenga, Jouke-Jan, Kleber, Marcus E, Le, Ngoc-Quynh, Lee, Jiwon, Lewis, Joshua P, Li-Gao, Ruifang, Luan, Jian’an, Malmberg, Anni, Mangino, Massimo, Marioni, Riccardo E, Martinez-Perez, Angel, Pankratz, Nathan, Polasek, Ozren, Richmond, Anne, Rodriguez, Benjamin AT, Rotter, Jerome I, Steri, Maristella, Suchon, Pierre, Trompet, Stella, Weiss, Stefan, Zare, Marjan, Auer, Paul, Cho, Michael H, Christofidou, Paraskevi, Davies, Gail, de Geus, Eco, Deleuze, Jean-François, Delgado, Graciela E, Ekunwe, Lynette, Faraday, Nauder, Gögele, Martin, Greinacher, Andreas, He, Gao, Howard, Tom, Joshi, Peter K, Kilpeläinen, Tuomas O, Lahti, Jari, Linneberg, Allan, Naitza, Silvia, Noordam, Raymond, Paüls-Vergés, Ferran, Rich, Stephen S, Rosendaal, Frits R, Rudan, Igor, Ryan, Kathleen A, Souto, Juan Carlos, van Rooij, Frank JA, Wang, Heming, Zhao, Wei, Becker, Lewis C, Beswick, Andrew, Brown, Michael R, Cade, Brian E, Campbell, Harry, Cho, Kelly, Crapo, James D, Curran, Joanne E, de Maat, Moniek PM, Doyle, Margaret, Elliott, Paul, Floyd, James S, Fuchsberger, Christian, Grarup, Niels, Guo, Xiuqing, Harris, Sarah E, Hou, Lifang, Kolcic, Ivana, Kooperberg, Charles, Menni, Cristina, Nauck, Matthias, O’Connell, Jeffrey R, Orrù, Valeria, Psaty, Bruce M, Räikkönen, Katri, Smith, Jennifer A, Soria, Jose Manuel, Stott, David J, van Hylckama Vlieg, Astrid, Watkins, Hugh, Willemsen, Gonneke, Wilson, Peter, Ben-Shlomo, Yoav, Blangero, John, Boomsma, Dorret, Cox, Simon R, Dehghan, Abbas, Eriksson, Johan G, Fiorillo, Edoardo, Fornage, Myriam, Hansen, Torben, Hayward, Caroline, Ikram, M. Arfan, Jukema, J Wouter, Kardia, Sharon LR, Lange, Leslie A, März, Winfried, Mathias, Rasika A, Mitchell, Braxton D, Mook-Kanamori, Dennis O, Morange, Pierre-Emmanuel, Pedersen, Oluf, Pramstaller, Peter P, Redline, Susan, Reiner, Alexander, Ridker, Paul M, Silverman, Edwin K, Spector, Tim D, Völker, Uwe, Wareham, Nick, Wilson, James F, Yao, Jie, Trégouët, David-Alexandre, Johnson, Andrew D, Wolberg, Alisa S, de Vries, Paul S, Sabater-Lleal, Maria, Morrison, Alanna C, and Smith, Nicholas L
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Article - Abstract
Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole genome sequencing (WGS) data provides better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analyzed WGS data from the NHLBI’s Trans-Omics for Precision Medicine (TOPMed) program (n=32,572), with array-based genotype data from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (n=131,340) imputed to the TOPMed or Haplotype Reference Consortium panel. We identified 18 loci that have not been identified in prior genetic studies of fibrinogen. Of these, four are driven by common variants of small effect with reported MAF at least 10% higher in African populations. Three ( SERPINA1, ZFP36L2 , and TLR10) signals contain predicted deleterious missense variants. Two loci, SOCS3 and HPN , each harbor two conditionally distinct, non-coding variants. The gene region encoding the protein chain subunits ( FGG;FGB;FGA ), contains 7 distinct signals, including one novel signal driven by rs28577061, a variant common (MAF=0.180) in African reference panels but extremely rare (MAF=0.008) in Europeans. Through phenome-wide association studies in the VA Million Veteran Program, we found associations between fibrinogen polygenic risk scores and thrombotic and inflammatory disease phenotypes, including an association with gout. Our findings demonstrate the utility of WGS to augment genetic discovery in diverse populations and offer new insights for putative mechanisms of fibrinogen regulation. KEY POINTS: Largest and most diverse genetic study of plasma fibrinogen identifies 54 regions (18 novel), housing 69 conditionally distinct variants (20 novel). Sufficient power achieved to identify signal driven by African population variant. Links to (1) liver enzyme, blood cell and lipid genetic signals, (2) liver regulatory elements, and (3) thrombotic and inflammatory disease.
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- 2023
43. Correction: Prediction of recurrent venous thrombosis in all patients with a first venous thrombotic event: The Leiden Thrombosis Recurrence Risk Prediction model (L-TRRiP)
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Timp, Jasmijn F., Braekkan, Sigrid K., Lijfering, Willem M., van Hylckama Vlieg, Astrid, Hansen, John-Bjarne, Rosendaal, Frits R., le Cessie, Saskia, and Cannegieter, Suzanne C.
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Biological sciences - Abstract
Author(s): Jasmijn F. Timp, Sigrid K. Braekkan, Willem M. Lijfering, Astrid van Hylckama Vlieg, John-Bjarne Hansen, Frits R. Rosendaal, Saskia le Cessie, Suzanne C. Cannegieter In Table 2, the coefficients [...]
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- 2021
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44. Bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities: a randomized controlled trial
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Koekenbier, Eva L., primary, Fohse, Konstantin, additional, van de Maat, Josephine S., additional, Oosterheert, Jan Jelrik, additional, van Nieuwkoop, Cees, additional, Hoogerwerf, Jacobien J., additional, Grobusch, Martin P., additional, van den Bosch, Maurice A.A.J., additional, van de Wijgert, Janneke H.H., additional, Netea, Mihai G., additional, Rosendaal, Frits R., additional, Bonten, Marc J.M., additional, Werkhoven, C.H. (Henri) van, additional, Aardenburg-van Huisstede, Astrid, additional, Ammerlaan, Heidi S.M., additional, Boersma, Willem G., additional, Brinkman, Kees, additional, Bruijning-Verhagen, Patricia C.J., additional, van Crevel, Reinout, additional, Delsing, Corine, additional, ten Doesschaten, Thijs, additional, Dofferhoff, Anton S.M., additional, Duijkers, Ruud, additional, Groenwold, Rolf H.H., additional, de Haas, Corine, additional, Hassing, Robert-Jan, additional, de Hoog, Marieke L.A., additional, Huijts, Susanne M., additional, van Hylckama-Vlieg, Astrid, additional, Jong, Eefje, additional, de Jong, Hanna K., additional, Knap, Martijn, additional, Koekenbier, Eva L., additional, Koenders, Michael, additional, Kouijzer, Ilse J.E., additional, Kramer, Henk, additional, van de Laar, Roel, additional, Lalmohamed, Arief, additional, Lensen, Karel-Jan D.F., additional, Lijfering, Willem M., additional, Magdelijns, Fabienne, additional, Meek, Bob, additional, Middelburg, Rutger A., additional, Moeniralam, Hazra S., additional, Mooijaart, Simon P., additional, van Munster, Barbara C., additional, ten Oever, Jaap, additional, Goossens, Marc Padros, additional, Peters, Vincent, additional, Postma, Douwe F., additional, Pouw, Niels, additional, Reesink, Herre J., additional, de Regt, Marieke J.A., additional, van der Reijden, Anneli C.J., additional, Schaakxs, R., additional, Slieker, Kitty, additional, Slingerland, Robbert J., additional, van Sluis, Nicolette L.J., additional, Stehouwer, Coen D.A., additional, van de Veerdonk, Frank, additional, Verbon, Annelies, additional, and van Werkhoven, C.H. (Henri), additional
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- 2023
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45. Additional file 1 of Association of ABO blood groups with venous thrombosis recurrence in middle-aged patients: insights from a weighted Cox analysis dedicated to ambispective design
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Munsch, Gaëlle, Goumidi, Louisa, van Hylckama Vlieg, Astrid, Ibrahim-Kosta, Manal, Bruzelius, Maria, Deleuze, Jean-François, Rosendaal, Frits R., Jacqmin-Gadda, Hélène, Morange, Pierre-Emmanuel, and Trégouët, David-Alexandre
- Abstract
Additional file 1.
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- 2023
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46. Additional file 1 of Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy
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Touw, Carolina E., Nemeth, Banne, van Adrichem, Raymond A., van Hylckama Vlieg, Astrid, Nelissen, Rob G. H. H., Lisman, Ton, and Cannegieter, Suzanne C.
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Additional file 1.
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- 2023
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47. FFP2-mondmasker of chirurgisch mondkapje bij COVID-19
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van Hylckama Vlieg, Astrid, Rosendaal, Frits, and Mook-Kanamori, Dennis
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- 2020
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48. Assessing the causal relationship between obesity and venous thromboembolism through a Mendelian Randomization study
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Lindström, Sara, Germain, Marine, Crous-Bou, Marta, Smith, Erin N., Morange, Pierre-Emmanuel, van Hylckama Vlieg, Astrid, de Haan, Hugoline G., Chasman, Daniel, Ridker, Paul, Brody, Jennifer, de Andrade, Mariza, Heit, John A., Tang, Weihong, DeVivo, Immaculata, Grodstein, Francine, Smith, Nicholas L., Tregouet, David, Kabrhel, Christopher, and for the INVENT Consortium
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- 2017
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49. Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
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Stacey, David, Chen, Lingyan, Stanczyk, Paulina J, Howson, Joanna MM, Mason, Amy M, Burgess, Stephen, MacDonald, Stephen, Langdown, Jonathan, McKinney, Harriett, Downes, Kate, Farahi, Neda, Peters, James E, Basu, Saonli, Pankow, James S, Tang, Weihong, Pankratz, Nathan, Sabater-Lleal, Maria, De Vries, Paul S, Smith, Nicholas L, Dehghan, Abbas, Heath, Adam S, Morrison, Alanna C, Reiner, Alex P, Johnson, Andrew, Richmond, Anne, Peters, Annette, Van Hylckama Vlieg, Astrid, McKnight, Barbara, Psaty, Bruce M, Hayward, Caroline, Ward-Caviness, Cavin, O’Donnell, Christopher, Chasman, Daniel, Strachan, David P, Tregouet, David A, Mook-Kanamori, Dennis, Gill, Dipender, Thibord, Florian, Asselbergs, Folkert W, Leebeek, Frank WG, Rosendaal, Frits R, Davies, Gail, Homuth, Georg, Temprano, Gerard, Campbell, Harry, Taylor, Herman A, Bressler, Jan, Huffman, Jennifer E, Rotter, Jerome I, Yao, Jie, Wilson, James F, Bis, Joshua C, Hahn, Julie M, Desch, Karl C, Wiggins, Kerri L, Raffield, Laura M, Bielak, Lawrence F, Yanek, Lisa R, Kleber, Marcus E, Mueller, Martina, Kavousi, Maryam, Mangino, Massimo, Conomos, Matthew P, Liu, Melissa, Brown, Michael R, Jhun, Min-A, Chen, Ming-Huei, De Maat, Moniek PM, Peyser, Patricia A, Elliot, Paul, Wei, Peng, Wild, Philipp S, Morange, Pierre E, Van Der Harst, Pim, Yang, Qiong, Le, Ngoc-Quynh, Marioni, Riccardo, Li, Ruifang, Damrauer, Scott M, Cox, Simon R, Trompet, Stella, Felix, Stephan B, Völker, Uwe, Koenig, Wolfgang, Jukema, J Wouter, Guo, Xiuqing, Gelinas, Amy D, Schneider, Daniel J, Janjic, Nebojsa, Samani, Nilesh J, Ye, Shu, Summers, Charlotte, Chilvers, Edwin R, Danesh, John, Paul, Dirk S, Chen, Lingyan [0000-0003-3750-6761], Howson, Joanna MM [0000-0001-7618-0050], Mason, Amy M [0000-0002-8019-0777], Burgess, Stephen [0000-0001-5365-8760], Peters, James E [0000-0002-9415-3440], Pankow, James S [0000-0001-7076-483X], Pankratz, Nathan [0000-0001-5958-693X], Sabater-Lleal, Maria [0000-0002-0128-379X], Schneider, Daniel J [0000-0001-6830-0905], Samani, Nilesh J [0000-0002-3286-8133], Ye, Shu [0000-0002-4126-4278], Summers, Charlotte [0000-0002-7269-2873], Chilvers, Edwin R [0000-0002-4230-9677], Paul, Dirk S [0000-0002-8230-0116], and Apollo - University of Cambridge Repository
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13/31 ,13/1 ,692/4019/592/2727 ,45/43 ,article ,631/208/212/2301 ,45/88 ,13/106 - Abstract
Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR-p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human recall-by-genotype and in vitro experimentation, we demonstrate that PROCR-219Gly increases plasma levels of (activated) protein C through endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, attenuating leukocyte–endothelial cell adhesion and vascular inflammation. We also associate PROCR-219Gly with an increased pro-thrombotic state via coagulation factor VII, a ligand of EPCR. Our study, which links PROCR-219Gly to CAD through anti-inflammatory mechanisms and to VTE through pro-thrombotic mechanisms, provides a framework to reveal the mechanisms underlying similar cross-phenotype associations.
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- 2022
50. Genetic variants in Cell Adhesion Molecule 1 (CADM1): A validation study of a novel endothelial cell venous thrombosis risk factor
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de Haan, Hugoline G., Bezemer, Irene D., Vossen, Carla Y., van Hylckama Vlieg, Astrid, Böehringer, Stefan, Hasstedt, Sandra J., Levy, Samuel, Rosendaal, Frits R., and Bovill, Edwin G.
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- 2014
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- View/download PDF
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