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1. Practice variation and outcomes of minimally invasive minor liver resections in patients with colorectal liver metastases: a population-based study

Author

de Graaff, Michelle R., Klaase, Joost M., de Kleine, Ruben, Elfrink, Arthur K. E., Swijnenburg, Rutger-Jan, M. Zonderhuis, Babs, D. Mieog, J. Sven, Derksen, Wouter J. M., Hagendoorn, Jeroen, van den Boezem, Peter B., Rijken, Arjen M., Gobardhan, Paul D., Marsman, Hendrik A., Liem, Mike S. L., Leclercq, Wouter K. G., van Heek, Tjarda N. T., Pantijn, Gijs A., Bosscha, Koop, Belt, Eric J. T., Vermaas, Maarten, Torrenga, Hans, Manusama, Eric R., van den Tol, Petrousjka, Oosterling, Steven J., den Dulk, Marcel, Grünhagen, Dirk J., and Kok, Niels F. M.

Published
2023
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2. Association of modified textbook outcome and overall survival after surgery for colorectal liver metastases: A nationwide analysis

Author

Manusama, Hans Torrenga E., van Heek, Tjarda N., Oosterling, S.J., Voigt, Kelly R., de Graaff, Michelle R., Verhoef, Cornelis, Kazemier, Geert, Swijneburg, Rutger J., Mieog, J.Sven D., Derksen, Wouter J.M., Buis, Carlijn I., Gobardhan, Paul D., Dulk, Marcel den, van Dam, Ronald M., Liem, Mike S.L., Leclercq, Wouter K.G., Bosscha, Koop, Belt, Eric J.T., Vermaas, Maarten, Kok, Niels F.M., Patijn, Gijs A., Marsman, H.M., van den Boezem, Peter B., Klaase, Joost M., and Grünhagen, Dirk J.

Published
2024
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4. Hospital variation in combined liver resection and thermal ablation for colorectal liver metastases and impact on short-term postoperative outcomes: a nationwide population-based study

Author

te Riele, Wouter W., de Boer, Marieke T., Dejong, Cees H.C., van Gulik, Thomas H., Hoogwater, Frederik J.H., Molenaar, I.Q., van der Leij, Christiaan, Moelker, Adriaan, Besselink, Marc G.H., Buis, Carlijn I., den Dulk, Marcel, Bosscha, Koop, Belt, Eric J.Th., Vermaas, Maarten, van Heek, Tjarda N.T., Oosterling, Steven J., Torrenga, Hans, Eker, Hasan H., Consten, Esther C.J., Elfrink, Arthur K.E., Nieuwenhuizen, Sanne, van den Tol, M. Petrousjka, Burgmans, Mark C., Prevoo, Warner, Coolsen, Marielle M.E., van den Boezem, Peter B., van Delden, Otto M., Hagendoorn, Jeroen, Patijn, Gijs A., Leclercq, Wouter K.G., Liem, Mike S.L., Rijken, Arjen M., Verhoef, Cornelis, Kuhlmann, Koert F.D., Ruiter, Simeon J.S., Grünhagen, Dirk J., Klaase, Joost M., Kok, Niels F.M., Meijerink, Martijn R., and Swijnenburg, Rutger-Jan

Published
2021
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5. Biotransformation and Epithelial Toxicity of Prenylated Phenolics from Licorice Roots (Glycyrrhizaspp.) in 3D Apical-Out Mucus-Producing Human Enteroids

Author

van Dinteren, Sarah, Araya-Cloutier, Carla, Bastiaan-Net, Shanna, Boudewijn, Anouk, van Heek, Tjarda, Vincken, Jean-Paul, Witkamp, Renger, and Meijerink, Jocelijn

Abstract

Apical-out enteroids mimic the in vivoenvironment well due to their accessible apical surface and mucus layer, making them an ideal model for studying the impact of (bioactive) food compounds. Generated human ileal apical-out enteroids showed a fucose-containing mucus layer surrounding the apical brush border on their exposure side, indicating their physiological relevance. Effects on the mucosal epithelium of antibacterial prenylated phenolics (glabridin, licochalcone A, and glycycoumarin) from licorice roots were investigated for cytotoxicity, cell viability, barrier integrity, and biotransformation. At concentrations up to 500 μg mL–1, licochalcone A and glycycoumarin did not significantly affect apical-out enteroids, with cytotoxicities of −6 ± 2 and −2 ± 2% and cell viabilities of 77 ± 22 and 77 ± 13%, respectively (p> 0.05). Conversely, 500 μg mL–1glabridin induced significant cytotoxicity (31 ± 25%, p< 0.05) and reduced cell viability (21 ± 14%, p< 0.01). Apical-out enteroids revealed differential sensitivities to prenylated phenolics not observed in apical-in enteroids and Caco-2 cells. Both enteroid models showed phase II biotransformation but differed in the extent of glucuronide conversion. The apical mucus layer of apical-out enteroids likely contributed to these differential interactions, potentially due to differences in electrostatic repulsion. This study underscores the relevance of 3D apical-out enteroid models and highlights the promise of prenylated phenolics for antimicrobial applications.

Published
2024
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6. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis

Author

Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, May, Anne M, Epi Kanker Team B, Cancer, Biostatistiek Onderwijs, Apotheek Bereidingen, Anatomie, MS CGO, MS Hematologie, MS Medische Oncologie, Epi Kanker, JC onderzoeksprogramma Cancer, Smit, Karel C, Derksen, Jeroen W G, Stellato, Rebecca K, van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J Th, Cloos-van Balen, Marissa, Coene, Peter Paul L O, Dekker, Jan Willem T, de Groot, Jan Willem, Haringhuizen, Annebeth W, van Halteren, Henk K, van Heek, Tjarda T, Helgason, Helgi H, Hendriks, Mathijs P, de Hingh, Ignace H J T, Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J B, Kok, Niels, Konsten, Joop L M, Los, Maartje, Meijerink, Martijn R, Mekenkamp, Leonie J M, Peeters, Koen C M J, Polée, Marco B, Rietbroek, Ron C, Schiphorst, Anandi H W, Schrauwen, Ruud W M, Schreinemakers, Jennifer, Sie, Mark P S, Simkens, Lieke, Sonneveld, Eric J A, Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J, Wasowicz-Kemps, Daria K, de Wilt, Johannes H W, Kok, Dieuwertje E, Winkels, Renate M, Kampman, Ellen, van Duijnhoven, Fränzel J B, Koopman, Miriam, and May, Anne M

Published
2024

7. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis

Author

Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, May, Anne M., Smit, Karel C., Derksen, Jeroen W.G., Stellato, Rebecca K., van Lanen, Anne-Sophie, Wesselink, Evertine, Belt, Eric J.T., Cloos-van Balen, Marissa, Coene, Peter Paul L.O., Dekker, Jan Willem T., de Groot, Jan Willem, Haringhuizen, Annebeth W., van Halteren, Henk K., van Heek, Tjarda T., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H.J.T., Hoekstra, Ronald, Houtsma, Danny, Janssen, Johan J.B., Kok, Niels, Konsten, Joop L.M., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J.M., Peeters, Koen C.M.J., Polée, Marco B., Rietbroek, Ron C., Schiphorst, Anandi H.W., Schrauwen, Ruud W.M., Schreinemakers, Jennifer, Sie, Mark P.S., Simkens, Lieke, Sonneveld, Eric J.A., Terheggen, Frederiek, Valkenburg-van Iersel, Liselot, Vles, Wouter J., Wasowicz-Kemps, Daria K., de Wilt, Johannes H.W., Kok, Dieuwertje E., Winkels, Renate M., Kampman, Ellen, van Duijnhoven, Fränzel J.B., Koopman, Miriam, and May, Anne M.

Abstract

Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until five years post-diagnosis.Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and six, twelve, twenty-four, and sixty (T6 to T60) months post-diagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population.Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared to men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared to the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6.Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at six months post-diagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.

Published
2024

8. Association of modified textbook outcome and overall survival after surgery for colorectal liver metastases: A nationwide analysis

Author

Voigt, Kelly R., primary, de Graaff, Michelle R., additional, Verhoef, Cornelis, additional, Kazemier, Geert, additional, Swijneburg, Rutger J., additional, Mieog, J.Sven D., additional, Derksen, Wouter J.M., additional, Buis, Carlijn I., additional, Gobardhan, Paul D., additional, Dulk, Marcel den, additional, van Dam, RonaldM., additional, Liem, Mike S.L., additional, Leclercq, Wouter K.G., additional, Bosscha, Koop, additional, Belt, Eric J.T., additional, Vermaas, Maarten, additional, Kok, Niels F.M., additional, Patijn, Gijs A., additional, Marsman, H.M., additional, van den Boezem, Peter B., additional, Klaase, Joost M., additional, Grünhagen, Dirk J., additional, Manusama, Hans Torrenga E., additional, van Heek, Tjarda N., additional, and Oosterling, S.J., additional

Published
2024
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9. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to Five Years after Diagnosis

Author

Smit, Karel C., primary, Derksen, Jeroen W.G., additional, Stellato, Rebecca K., additional, van Lanen, Anne-Sophie, additional, Wesselink, Evertine, additional, Belt, Eric J. Th., additional, Cloos-van Balen, Marissa, additional, Coene, Peter Paul L.O., additional, Dekker, Jan Willem T., additional, de Groot, Jan Willem, additional, Haringhuizen, Annebeth W., additional, van Halteren, Henk K., additional, van Heek, Tjarda T., additional, Helgason, Helgi H., additional, Hendriks, Mathijs P., additional, de Hingh, Ignace H.J.T., additional, Hoekstra, Ronald, additional, Houtsma, Danny, additional, Janssen, Johan J.B., additional, Kok, Niels, additional, Konsten, Joop L.M., additional, Los, Maartje, additional, Meijerink, Martijn R., additional, Mekenkamp, Leonie J.M., additional, Peeters, Koen C.M.J., additional, Polée, Marco B., additional, Rietbroek, Ron C., additional, Schiphorst, Anandi H.W., additional, Schrauwen, Ruud W.M., additional, Schreinemakers, Jennifer, additional, Sie, Mark P.S., additional, Simkens, Lieke, additional, Sonneveld, Eric J.A., additional, Terheggen, Frederiek, additional, Valkenburg-van Iersel, Liselot, additional, Vles, Wouter J., additional, Wasowicz-Kemps, Daria K., additional, de Wilt, Johannes H.W., additional, Kok, Dieuwertje E., additional, Winkels, Renate M., additional, Kampman, Ellen, additional, van Duijnhoven, Fränzel J.B., additional, Koopman, Miriam, additional, and May, Anne M., additional

Published
2023
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10. Practice variation and outcomes of minimally invasive minor liver resections in patients with colorectal liver metastases:a population-based study

Author

de Graaff, Michelle R., Klaase, Joost M., de Kleine, Ruben, Elfrink, Arthur K.E., Swijnenburg, Rutger Jan, M. Zonderhuis, Babs, D. Mieog, J. Sven, Derksen, Wouter J.M., Hagendoorn, Jeroen, van den Boezem, Peter B., Rijken, Arjen M., Gobardhan, Paul D., Marsman, Hendrik A., Liem, Mike S.L., Leclercq, Wouter K.G., van Heek, Tjarda N.T., Pantijn, Gijs A., Bosscha, Koop, Belt, Eric J.T., Vermaas, Maarten, Torrenga, Hans, Manusama, Eric R., van den Tol, Petrousjka, Oosterling, Steven J., den Dulk, Marcel, Grünhagen, Dirk J., Kok, Niels F.M., de Graaff, Michelle R., Klaase, Joost M., de Kleine, Ruben, Elfrink, Arthur K.E., Swijnenburg, Rutger Jan, M. Zonderhuis, Babs, D. Mieog, J. Sven, Derksen, Wouter J.M., Hagendoorn, Jeroen, van den Boezem, Peter B., Rijken, Arjen M., Gobardhan, Paul D., Marsman, Hendrik A., Liem, Mike S.L., Leclercq, Wouter K.G., van Heek, Tjarda N.T., Pantijn, Gijs A., Bosscha, Koop, Belt, Eric J.T., Vermaas, Maarten, Torrenga, Hans, Manusama, Eric R., van den Tol, Petrousjka, Oosterling, Steven J., den Dulk, Marcel, Grünhagen, Dirk J., and Kok, Niels F.M.

Abstract

Introduction: In 2017, the Southampton guideline stated that minimally invasive liver resections (MILR) should considered standard practice for minor liver resections. This study aimed to assess recent implementation rates of minor MILR, factors associated with performing MILR, hospital variation, and outcomes in patients with colorectal liver metastases (CRLM). Methods: This population-based study included all patients who underwent minor liver resection for CRLM in the Netherlands between 2014 and 2021. Factors associated with MILR and nationwide hospital variation were assessed using multilevel multivariable logistic regression. Propensity-score matching (PSM) was applied to compare outcomes between minor MILR and minor open liver resections. Overall survival (OS) was assessed with Kaplan–Meier analysis on patients operated until 2018. Results: Of 4,488 patients included, 1,695 (37.8%) underwent MILR. PSM resulted in 1,338 patients in each group. Implementation of MILR increased to 51.2% in 2021. Factors associated with not performing MILR included treatment with preoperative chemotherapy (aOR 0.61 CI:0.50–0.75, p < 0.001), treatment in a tertiary referral hospital (aOR 0.57 CI:0.50–0.67, p < 0.001), and larger diameter and number of CRLM. Significant hospital variation was observed in use of MILR (7.5% to 93.0%). After case-mix correction, six hospitals performed fewer, and six hospitals performed more MILRs than expected. In the PSM cohort, MILR was associated with a decrease in blood loss (aOR 0.99 CI:0.99–0.99, p < 0.01), cardiac complications (aOR 0.29, CI:0.10–0.70, p = 0.009), IC admissions (aOR 0.66, CI:0.50–0.89, p = 0.005), and shorter hospital stay (aOR CI:0.94–0.99, p < 0.01). Five-year OS rates for MILR and OLR were 53.7% versus 48.6%, p = 0.21. Conclusion: Although uptake of MILR is increasing in the Netherlands, significant hospital variation remains. MILR benefits short-term outcomes, while overall survival is comparable to open liv

Published
2023

11. A nationwide assessment of hepatocellular adenoma resection:Indications and pathological discordance

Author

Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, de Meijer, Vincent E, Haring, Martijn P D, Elfrink, Arthur K E, Oudmaijer, Christiaan A J, Andel, Paul C M, Furumaya, Alicia, de Jong, Nenke, Willems, Colin J J M, Huits, Thijs, Sijmons, Julie M L, Belt, Eric J T, Bosscha, Koop, Consten, Esther C J, Coolsen, Mariëlle M E, van Duijvendijk, Peter, Erdmann, Joris I, Gobardhan, Paul, de Haas, Robbert J, van Heek, Tjarda, Lam, Hwai-Ding, Leclercq, Wouter K G, Liem, Mike S L, Marsman, Hendrik A, Patijn, Gijs A, Terkivatan, Türkan, Zonderhuis, Babs M, Molenaar, Izaak Quintus, Te Riele, Wouter W, Hagendoorn, Jeroen, Schaapherder, Alexander F M, IJzermans, Jan N M, Buis, Carlijn I, Klaase, Joost M, de Jong, Koert P, and de Meijer, Vincent E

Abstract

Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors (p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis.

Published
2023

12. Practice variation and outcomes of minimally invasive minorliver resections in patients with colorectal liver metastases: a population-based study

Author

de Graaff, Michelle R., Klaase, Joost M., de Kleine, Ruben, Elfrink, Arthur K. E., Swijnenburg, Rutger-Jan, M. Zonderhuis, Babs, D. Mieog, J. Sven, Derksen, Wouter J. M., Hagendoorn, Jeroen, van den Boezem, Peter B., Rijken, Arjen M., Gobardhan, Paul D., Marsman, Hendrik A., Liem, Mike S. L., Leclercq, Wouter K. G., van Heek, Tjarda N. T., Pantijn, Gijs A., Bosscha, Koop, Belt, Eric J. T., Vermaas, Maarten, Torrenga, Hans, Manusama, Eric R., van den Tol, Petrousjka, Oosterling, Steven J., den Dulk, Marcel, Grünhagen, Dirk J., and Kok, Niels F. M.

Abstract

Introduction: In 2017, the Southampton guideline stated that minimally invasive liver resections (MILR) should considered standard practice for minor liver resections. This study aimed to assess recent implementation rates of minor MILR, factors associated with performing MILR, hospital variation, and outcomes in patients with colorectal liver metastases (CRLM). Methods: This population-based study included all patients who underwent minor liver resection for CRLM in the Netherlands between 2014 and 2021. Factors associated with MILR and nationwide hospital variation were assessed using multilevel multivariable logistic regression. Propensity-score matching (PSM) was applied to compare outcomes between minor MILR and minor open liver resections. Overall survival (OS) was assessed with Kaplan–Meier analysis on patients operated until 2018. Results: Of 4,488 patients included, 1,695 (37.8%) underwent MILR. PSM resulted in 1,338 patients in each group. Implementation of MILR increased to 51.2% in 2021. Factors associated with not performing MILR included treatment with preoperative chemotherapy (aOR 0.61 CI:0.50–0.75, p&lt; 0.001), treatment in a tertiary referral hospital (aOR 0.57 CI:0.50–0.67, p&lt; 0.001), and larger diameter and number of CRLM. Significant hospital variation was observed in use of MILR (7.5% to 93.0%). After case-mix correction, six hospitals performed fewer, and six hospitals performed more MILRs than expected. In the PSM cohort, MILR was associated with a decrease in blood loss (aOR 0.99 CI:0.99–0.99, p&lt; 0.01), cardiac complications (aOR 0.29, CI:0.10–0.70, p= 0.009), IC admissions (aOR 0.66, CI:0.50–0.89, p= 0.005), and shorter hospital stay (aOR CI:0.94–0.99, p&lt; 0.01). Five-year OS rates for MILR and OLR were 53.7% versus 48.6%, p= 0.21. Conclusion: Although uptake of MILR is increasing in the Netherlands, significant hospital variation remains. MILR benefits short-term outcomes, while overall survival is comparable to open liver surgery. Graphical abstract:

Published
2023
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13. Antibiotic prophylaxis for acute cholecystectomy: PEANUTS II multicentre randomized non-inferiority clinical trial

Author

van Braak, Willemieke G., primary, Ponten, Jeroen E. H., additional, Loozen, Charlotte S., additional, Schots, Judith P. M., additional, van Geloven, Anna A. W., additional, Donkervoort, Sandra C., additional, Nieuwenhuijzen, Grard A. P., additional, Besselink, Marc G., additional, van Heek, Tjarda N. T., additional, de Reuver, Philip R., additional, Vlaminckx, Bart, additional, Kelder, Johannes C., additional, Knibbe, Catherijne A. J., additional, van Santvoort, Hjalmar C., additional, and Boerma, Djamila, additional

Published
2022
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14. A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance.

Author

Haring, Martijn P. D., Elfrink, Arthur K. E., Oudmaijer, Christiaan A. J., Andel, Paul C. M., Furumaya, Alicia, de Jong, Nenke, Willems, Colin J. J. M., Huits, Thijs, Sijmons, Julie M. L., Belt, Eric J. T., Bosscha, Koop, Consten, Esther C. J., Coolsen, Mariëlle M. E., van Duijvendijk, Peter, Erdmann, Joris I., Gobardhan, Paul, de Haas, Robbert J., van Heek, Tjarda, Hwai-Ding Lam, and Leclercq, Wouter K. G.

Subjects
CONTRAST-enhanced magnetic resonance imaging, PREOPERATIVE risk factors, LIVER tumors, LOGISTIC regression analysis
Abstract

Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50mm compared to HCAs = 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (=50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors (p = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre) malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50mm (adjusted odds ratio [aOR], 3.4; p < 0.01), male sex (aOR, 3.7; p = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Hospital variation in combined liver resection and thermal ablation for colorectal liver metastases and impact on short-term postoperative outcomes: a nationwide population-based study

Author

Elfrink, Arthur K.E., primary, Nieuwenhuizen, Sanne, additional, van den Tol, M. Petrousjka, additional, Burgmans, Mark C., additional, Prevoo, Warner, additional, Coolsen, Marielle M.E., additional, van den Boezem, Peter B., additional, van Delden, Otto M., additional, Hagendoorn, Jeroen, additional, Patijn, Gijs A., additional, Leclercq, Wouter K.G., additional, Liem, Mike S.L., additional, Rijken, Arjen M., additional, Verhoef, Cornelis, additional, Kuhlmann, Koert F.D., additional, Ruiter, Simeon J.S., additional, Grünhagen, Dirk J., additional, Klaase, Joost M., additional, Kok, Niels F.M., additional, Meijerink, Martijn R., additional, Swijnenburg, Rutger-Jan, additional, te Riele, Wouter W., additional, de Boer, Marieke T., additional, Dejong, Cees H.C., additional, van Gulik, Thomas H., additional, Hoogwater, Frederik J.H., additional, Molenaar, I.Q., additional, van der Leij, Christiaan, additional, Moelker, Adriaan, additional, Besselink, Marc G.H., additional, Buis, Carlijn I., additional, den Dulk, Marcel, additional, Bosscha, Koop, additional, Belt, Eric J.Th., additional, Vermaas, Maarten, additional, van Heek, Tjarda N.T., additional, Oosterling, Steven J., additional, Torrenga, Hans, additional, Eker, Hasan H., additional, and Consten, Esther C.J., additional

Published
2021
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17. Multicenter Observational Study of Adhesion Formation After Open-and Laparoscopic Surgery for Colorectal Cancer

Author

Stommel, Martijn W. J., primary, ten Broek, Richard P. G., additional, Strik, Chema, additional, Slooter, Gerrit D., additional, Verhoef, Cornelis, additional, Grünhagen, Dirk J., additional, van Duijvendijk, Peter, additional, Bemelmans, Marc H. A., additional, den Dulk, Marcel, additional, Sietses, Colin, additional, van Heek, Tjarda N. T., additional, van den Boezem, Peter B., additional, de Wilt, Johannes H. W., additional, and van Goor, Harry, additional

Published
2018
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20. Identification of osteopontin as a serum marker of ampullary carcinoma by gene expression profiling

Author

Van Heek, Tjarda, primary, Maitra, Anirban, additional, Koopmann, Jens, additional, Fedarko, Neil, additional, Jain, Alka, additional, Rahman, Ayman, additional, Iacobuzio=Donahue, Christine, additional, Adsay, Volkan, additional, Ashfaq, Raheela, additional, Yeo, Charles, additional, Cameron, John L., additional, Offerhaus, Johan A., additional, Hruban, Ralph, additional, Berg, Karin D., additional, and Goggins, Michael, additional

Published
2003
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22. Discovery of Novel Tumor Markers of Pancreatic Cancer using Global Gene Expression Technology

Author

Iacobuzio-Donahue, Christine A., primary, Maitra, Anirban, additional, Shen-Ong, Grace L., additional, van Heek, Tjarda, additional, Ashfaq, Raheela, additional, Meyer, Renee, additional, Walter, Kimberly, additional, Berg, Karin, additional, Hollingsworth, Michael A., additional, Cameron, John L., additional, Yeo, Charles J., additional, Kern, Scott E., additional, Goggins, Michael, additional, and Hruban, Ralph H., additional

Published
2002
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23. IHPBA Newsletter.

Author

Lau, W. Y. and van Heek, Tjarda

Subjects
*ASSOCIATIONS, institutions, etc., *CONFERENCES & conventions, *LIVER, *PANCREAS, *BILE ducts
Abstract

Presents updates on the International Hepato-Pancreato-Biliary Association as of September 2002. Means to help increase the number of members; Highlights of the 5th World Congress of the organization; Election of officers.

Published
2002
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24. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis.

Author

van Heek, Tjarda, Rader, Anne E, Offerhaus, G Johan A, McCarthy, Denis M, Goggins, Michael, Hruban, Ralph H, and Wilentz, Robb E

Abstract

Between January 1997 and February 2000, 101 fine-needle pancreatic aspirates were obtained. After a cytologic diagnosis was made, possible molecular alterations were determined on the 94 aspirates with adequate tissue using a molecular panel (K-ras, p53, and DPC4 [MAD4] genes). The 94 aspirates were categorized as follows: diagnostic of adenocarcinoma, 48 (51%); atypical (suggestive of but not diagnostic of adenocarcinoma), 19 (20%); negative for adenocarcinoma, 25 (2 7%); diagnostic of a neoplasm other than adenocarcinoma, 2 (2%). Clinical follow-up revealed that 3 patients (12%) with negative cytologic diagnoses and 12 patients (63%) with atypical cytologic diagnoses had adenocarcinoma. Of 63 with a final diagnosis of adenocarcinoma, 42 (67%) had an alteration in at least 1 of the genes analyzed. In contrast, only 2 (6%) of 31 patients without adenocarcinoma had an alteration in 1 gene on the panel. Overall, the molecular analyses supported the diagnosis of adenocarcinoma in 6 (32%) of 19 aspirates originally diagnosed as atypical by cytology alone. A molecular panel that includes the K-ras, p53, and DPC4 (MAD4) genes correlates with and can supplement traditional cytologic diagnosis of pancreatic fine-needle aspirates.

Published
2002
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25. Determinants of Physical Activity among Patients with Colorectal Cancer: From Diagnosis to 5 Years after Diagnosis.

Author

Smit KC, Derksen JWG, Stellato RK, VAN Lanen AS, Wesselink E, Belt EJT, Balen MC, Coene PPLO, Dekker JWT, DE Groot JW, Haringhuizen AW, VAN Halteren HK, VAN Heek TT, Helgason HH, Hendriks MP, DE Hingh IHJT, Hoekstra R, Houtsma D, Janssen JJB, Kok N, Konsten JLM, Los M, Meijerink MR, Mekenkamp LJM, Peeters KCMJ, Polée MB, Rietbroek RC, Schiphorst AHW, Schrauwen RWM, Schreinemakers J, Sie MPS, Simkens L, Sonneveld EJA, Terheggen F, Iersel LV, Vles WJ, Wasowicz-Kemps DK, DE Wilt JHW, Kok DE, Winkels RM, Kampman E, VAN Duijnhoven FJB, Koopman M, and May AM

Subjects
Male, Humans, Female, Exercise, Cohort Studies, Fatigue, Quality of Life, Colorectal Neoplasms diagnosis
Abstract

Introduction: Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis., Methods: Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I-III colon (CC), stage I-III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I-III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population., Results: In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6., Conclusions: Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine.)

Published
2024
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26. A nationwide assessment of hepatocellular adenoma resection: Indications and pathological discordance.

Author

Haring MPD, Elfrink AKE, Oudmaijer CAJ, Andel PCM, Furumaya A, de Jong N, Willems CJJM, Huits T, Sijmons JML, Belt EJT, Bosscha K, Consten ECJ, Coolsen MME, van Duijvendijk P, Erdmann JI, Gobardhan P, de Haas RJ, van Heek T, Lam HD, Leclercq WKG, Liem MSL, Marsman HA, Patijn GA, Terkivatan T, Zonderhuis BM, Molenaar IQ, Te Riele WW, Hagendoorn J, Schaapherder AFM, IJzermans JNM, Buis CI, Klaase JM, de Jong KP, and de Meijer VE

Subjects
Humans, Male, Adult, Middle Aged, Retrospective Studies, Magnetic Resonance Imaging methods, Adenoma, Liver Cell diagnostic imaging, Adenoma, Liver Cell surgery, Liver Neoplasms diagnostic imaging, Liver Neoplasms surgery, Carcinoma, Hepatocellular pathology
Abstract

Hepatocellular adenomas (HCAs) are benign liver tumors associated with bleeding or malignant transformation. Data on the indication for surgery are scarce. We analyzed indications and outcome of patients operated for HCAs < 50 mm compared to HCAs ≥ 50 mm. Changes in final postoperative diagnosis were assessed. We performed a retrospective study that included patients who underwent resection for (suspected) HCAs in the Netherlands from 2014 to 2019. Indication for resection was analyzed and stratified for small (<50 mm) and large (≥50 mm) tumors. Logistic regression analysis was performed on factors influencing change in tumor diagnosis. Out of 222 patients who underwent surgery, 44 (20%) patients had a tumor <50 mm. Median age was 46 (interquartile range [IQR], 33-56) years in patients with small tumors and 37 (IQR, 31-46) years in patients with large tumors ( p  = 0.016). Patients with small tumors were more frequently men (21% vs. 5%, p  = 0.002). Main indications for resection in patients with small tumors were suspicion of (pre)malignancy (55%), (previous) bleeding (14%), and male sex (11%). Patients with large tumors received operations because of tumor size >50 mm (52%), suspicion of (pre)malignancy (28%), and (previous) bleeding (5.1%). No difference was observed in HCA-subtype distribution between small and large tumors. Ninety-six (43%) patients had a postoperative change in diagnosis. Independent risk factors for change in diagnosis were tumor size <50 mm (adjusted odds ratio [aOR], 3.4; p  < 0.01), male sex (aOR, 3.7; p  = 0.03), and lack of hepatobiliary contrast-enhanced magnetic resonance imaging (CE-MRI) (aOR, 1.8; p  = 0.04). Resection for small (suspected) HCAs was mainly indicated by suspicion of (pre)malignancy, whereas for large (suspected) HCAs, tumor size was the most prevalent indication. Male sex, tumor size <50 mm, and lack of hepatobiliary CE-MRI were independent risk factors for postoperative change in tumor diagnosis., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc on behalf of the American Association for the Study of Liver Diseases.)

Published
2022
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