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2. Development, Use, and Impact of a Global Laboratory Database During the 2014 Ebola Outbreak in West Africa

Author

Durski, Kara N., Singaravelu, Shalini, Teo, Junxiong, Naidoo, Dhamari, Bawo, Luke, Jambai, Amara, Keita, Sakoba, Yahaya, Ali Ahmed, Muraguri, Beatrice, Ahounou, Brice, Katawera, Victoria, Kuti-George, Fredson, Nebie, Yacouba, Kohar, T. Henry, Hardy, Patrick Jowlehpah, Djingarey, Mamoudou Harouna, Kargbo, David, Mahmoud, Nuha, Assefa, Yewondwossen, Condell, Orla, N'Faly, Magassouba, Van Gurp, Leon, Lamanu, Margaret, Ryan, Julia, Diallo, Boubacar, Daffae, Foday, Jackson, Dikena, Malik, Fayyaz Ahmed, Raftery, Philomena, and Formenty, Pierre

Published
2017

4. Development, Use, and Impact of a Global Laboratory Database During the 2014 Ebola Outbreak in West Africa

Author

Durski, Kara N., Singaravelu, Shalini, Teo, Junxiong, Naidoo, Dhamari, Bawo, Luke, Jambai, Amara, Keita, Sakoba, Yahaya, Ali Ahmed, Muraguri, Beatrice, Ahounou, Brice, Katawera, Victoria, Kuti-George, Fredson, Nebie, Yacouba, Kohar, T. Henry, Hardy, Patrick Jowlehpah, Djingarey, Mamoudou Harouna, Kargbo, David, Mahmoud, Nuha, Assefa, Yewondwossen, Condell, Orla, N'Faly, Magassouba, Van Gurp, Leon, Lamanu, Margaret, Ryan, Julia, Diallo, Boubacar, Daffae, Foday, Jackson, Dikena, Malik, Fayyaz Ahmed, Raftery, Philomena, Formenty, Pierre, Durski, Kara N., Singaravelu, Shalini, Teo, Junxiong, Naidoo, Dhamari, Bawo, Luke, Jambai, Amara, Keita, Sakoba, Yahaya, Ali Ahmed, Muraguri, Beatrice, Ahounou, Brice, Katawera, Victoria, Kuti-George, Fredson, Nebie, Yacouba, Kohar, T. Henry, Hardy, Patrick Jowlehpah, Djingarey, Mamoudou Harouna, Kargbo, David, Mahmoud, Nuha, Assefa, Yewondwossen, Condell, Orla, N'Faly, Magassouba, Van Gurp, Leon, Lamanu, Margaret, Ryan, Julia, Diallo, Boubacar, Daffae, Foday, Jackson, Dikena, Malik, Fayyaz Ahmed, Raftery, Philomena, and Formenty, Pierre

Abstract

The usefulness and value of a multifunctional global laboratory database is far reaching, with uses including but not limited to informing local outbreak interventions, developing global outbreak response strategies, virtual biobanking, and disease forecasting.

Published
2021

5. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

Author

Furuyama, Kenichiro, primary, Chera, Simona, additional, van, Gurp Leon, additional, Oropeza, Daniel, additional, Ghila, Luiza, additional, Damond, Nicolas, additional, Vethe, Heidrun, additional, Paulo, Joao A, additional, Joosten, Antoinette M, additional, Berney, Thierry, additional, Bosco, Domenico, additional, Dorrell, Craig, additional, Grompe, Markus, additional, Raeder, Helge, additional, Roep, Bart O, additional, Thorel, Fabrizio, additional, and Herrera, Pedro L, additional

Published
2019
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8. A Single-Cell Transcriptome Atlas of the Human Pancreas

Author

Muraro, Mauro J., Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A., Carlotti, Francoise, de Koning, Eelco J.P., van Oudenaarden, Alexander, Muraro, Mauro J., Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A., Carlotti, Francoise, de Koning, Eelco J.P., and van Oudenaarden, Alexander

Published
2016

9. A Single-Cell Transcriptome Atlas of the Human Pancreas

Author

Muraro, Mauro J, Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A, Carlotti, Francoise, de Koning, Eelco J P, van Oudenaarden, Alexander, Muraro, Mauro J, Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A, Carlotti, Francoise, de Koning, Eelco J P, and van Oudenaarden, Alexander

Abstract

To understand organ function, it is important to have an inventory of its cell types and of their corresponding marker genes. This is a particularly challenging task for human tissues like the pancreas, because reliable markers are limited. Hence, transcriptome-wide studies are typically done on pooled islets of Langerhans, obscuring contributions from rare cell types and of potential subpopulations. To overcome this challenge, we developed an automated platform that uses FACS, robotics, and the CEL-Seq2 protocol to obtain the transcriptomes of thousands of single pancreatic cells from deceased organ donors, allowing in silico purification of all main pancreatic cell types. We identify cell type-specific transcription factors and a subpopulation of REG3A-positive acinar cells. We also show that CD24 and TM4SF4 expression can be used to sort live alpha and beta cells with high purity. This resource will be useful for developing a deeper understanding of pancreatic biology and pathophysiology of diabetes mellitus.

Published
2016

10. A Single-Cell Transcriptome Atlas of the Human Pancreas

Author

Regenerative Medicine and Stem Cells, Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, Muraro, Mauro J., Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A., Carlotti, Francoise, de Koning, Eelco J.P., van Oudenaarden, Alexander, Regenerative Medicine and Stem Cells, Hubrecht Institute with UMC, CMM Sectie Molecular Cancer Research, Cancer, Muraro, Mauro J., Dharmadhikari, Gitanjali, Grün, Dominic, Groen, Nathalie, Dielen, Tim, Jansen, Erik, van Gurp, Leon, Engelse, Marten A., Carlotti, Francoise, de Koning, Eelco J.P., and van Oudenaarden, Alexander

Published
2016

11. A Single-Cell Transcriptome Atlas of the Human Pancreas

Author

Muraro, Mauro J., primary, Dharmadhikari, Gitanjali, additional, Grün, Dominic, additional, Groen, Nathalie, additional, Dielen, Tim, additional, Jansen, Erik, additional, van Gurp, Leon, additional, Engelse, Marten A., additional, Carlotti, Francoise, additional, de Koning, Eelco J.P., additional, and van Oudenaarden, Alexander, additional

Published
2016
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12. Intravital Microscopy Through an Abdominal Imaging Window Reveals a Pre-Micrometastasis Stage During Liver Metastasis

Author

Ritsma, Laila, primary, Steller, Ernst J. A., additional, Beerling, Evelyne, additional, Loomans, Cindy J. M., additional, Zomer, Anoek, additional, Gerlach, Carmen, additional, Vrisekoop, Nienke, additional, Seinstra, Daniëlle, additional, van Gurp, Leon, additional, Schäfer, Ronny, additional, Raats, Daniëlle A., additional, de Graaff, Anko, additional, Schumacher, Ton N., additional, de Koning, Eelco J. P., additional, Rinkes, Inne H. Borel, additional, Kranenburg, Onno, additional, and Rheenen, Jacco van, additional

Published
2012
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13. Mo1978 Induced WNT5A Expression is Well-Tolerated in Adult Mice, but Perturbs Outgrowth and Intestinal Elongation in Embryos

Author

Bakker, Elvira R., primary, Raghoebir, Lalini, additional, Franken, Patrick, additional, Helvensteijn, Werner, additional, Van Gurp, Leon, additional, Meijlink, Frits, additional, Van der Valk, Martin A., additional, Rottier, Robbert J., additional, Kuipers, Ernst J., additional, van Veelen, Wendy, additional, and Smits, Ron, additional

Published
2012
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14. C-Terminal Phosphorylation of β-Catenin Increases Wnt Signaling and Intestinal Tumorigenesis

Author

van Veelen, Wendy, primary, Le, Ngoc Hang, additional, Helvensteijn, Werner, additional, Blonden, Lau, additional, Theeuwes, Myrte, additional, Bakker, Elvira, additional, Franken, Patrick, additional, Van Gurp, Leon, additional, Meijlink, Frits, additional, Van der Valk, Martin A., additional, Kuipers, Ernst J., additional, Fodde, Riccardo, additional, and Smits, Ron, additional

Published
2011
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15. Development, Use, and Impact of a Global Laboratory Database During the 2014 Ebola Outbreak in West Africa

Author

Durski, Kara N., Singaravelu, Shalini, Teo, Junxiong, Naidoo, Dhamari, Bawo, Luke, Jambai, Amara, Keita, Sakoba, Yahaya, Ali Ahmed, Muraguri, Beatrice, Ahounou, Brice, Katawera, Victoria, Kuti-George, Fredson, Nebie, Yacouba, Kohar, T. Henry, Hardy, Patrick Jowlehpah, Djingarey, Mamoudou Harouna, Kargbo, David, Mahmoud, Nuha, Assefa, Yewondwossen, Condell, Orla, N'Faly, Magassouba, Van Gurp, Leon, Lamanu, Margaret, Ryan, Julia, Diallo, Boubacar, Daffae, Foday, Jackson, Dikena, Malik, Fayyaz Ahmed, Raftery, Philomena, Formenty, Pierre, Durski, Kara N., Singaravelu, Shalini, Teo, Junxiong, Naidoo, Dhamari, Bawo, Luke, Jambai, Amara, Keita, Sakoba, Yahaya, Ali Ahmed, Muraguri, Beatrice, Ahounou, Brice, Katawera, Victoria, Kuti-George, Fredson, Nebie, Yacouba, Kohar, T. Henry, Hardy, Patrick Jowlehpah, Djingarey, Mamoudou Harouna, Kargbo, David, Mahmoud, Nuha, Assefa, Yewondwossen, Condell, Orla, N'Faly, Magassouba, Van Gurp, Leon, Lamanu, Margaret, Ryan, Julia, Diallo, Boubacar, Daffae, Foday, Jackson, Dikena, Malik, Fayyaz Ahmed, Raftery, Philomena, and Formenty, Pierre

Abstract

The usefulness and value of a multifunctional global laboratory database is far reaching, with uses including but not limited to informing local outbreak interventions, developing global outbreak response strategies, virtual biobanking, and disease forecasting.

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