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830 results on '"van Griensven, M"'

8. Enthesis

Author

Peniche Silva, C J, Müller, S A, Quirk, N, De la Vega, R E, Coenen, M J, Evans, C H, Balmayor, E R, van Griensven, M, CBITE, and RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE)

Subjects
Rotator Cuff, Osteogenesis, Animals, Fibrocartilage, Achilles Tendon/pathology, Achilles Tendon, Bone and Bones, Rats
Abstract

European cells & materials : eCM 44, 43-55 (2022). doi:10.22203/eCM.v044a03, Published by Univ. of Wales, Aberystwyth, Wales

Published
2022

9. Mechanical and strain behaviour of human Achilles tendon during in vitro testing to failure

Author

Nagelli, C V, Hooke, A, Quirk, N, De Padilla, C L, Hewett, T E, van Griensven, M, Coenen, M, Berglund, L, Evans, C H, Müller, S A, CBITE, and RS: MERLN - Cell Biology - Inspired Tissue Engineering (CBITE)

Subjects
Rupture, tendon rupture, Achilles tendon, Tendinopathy, Strain behaviour, &nbsp, Humans, digital image correlation, In Vitro Techniques, musculoskeletal system, Biomechanical Phenomena
Abstract

The Achilles tendon is the strongest tendon in the human body but its mechanical behaviour during failure has been little studied and the basis of its high tensile strength has not been elucidated in detail. In the present study, healthy, human, Achilles tendons were loaded to failure in an anatomically authentic fashion while the local deformation and strains were studied in real time, with very high precision, using digital image correlation (DIC). The values determined for the strength of the Achilles tendon were at the high end of those reported in the literature, consistent with the absence of a pre-existing tendinopathy in the samples, as determined by careful gross inspection and histology. Early in the loading cycle, the proximal region of the tendon accumulated high lateral strains while longitudinal strains remained low. However, immediately before rupture, the mid-substance of the Achilles tendon, its weakest part, started to show high longitudinal strains. These new insights advance the understanding of the mechanical behaviour of tendons as they are stretched to failure.

Published
2022

29. Effects of cyclic longitudinal mechanical strain and dexamethasone on osteogenic differentiation of human bone marrow stromal cells

Author

Jagodzinski M., Drescher M., Zeichen J., Hankemeier S., Krettek C., Bosch U., and van Griensven M.

Subjects
Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811
Abstract

The aim of the study was to investigate the effect of cyclic mechanical strain on differentiation markers in the presence or absence of dexamethasone. Human bone marrow stromal cells (BMSC) from seven donors (32.5±6.2 years) were cultivated with (D+) or without (D-) dexamethasone. A cyclic mechanical strain with an elongation of 2% (D+2; D-2) or 8% (D+8; D-8) was applied for three days with a stimulation time of three times two hours each day. Levels of alkaline phosphatase (ALP) and osteocalcin (OC) were compared after time intervals of four and seven days. mRNA expression of Collagen I, III and Cbfa1 was investigated after one, four, and seven days. ALP levels were significantly increased in the D+8 group after four and seven days (147.1±6.3%; p

Published
2004

33. Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing

Author

MS Nefrologie, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Circulatory Health, Schumacher, A., Rookmaaker, M. B., Joles, J. A., Kramann, R., Nguyen, T. Q., van Griensven, M., LaPointe, V. L.S., MS Nefrologie, Regenerative Medicine and Stem Cells, Pathologie Pathologen staf, Circulatory Health, Schumacher, A., Rookmaaker, M. B., Joles, J. A., Kramann, R., Nguyen, T. Q., van Griensven, M., and LaPointe, V. L.S.

Published
2021

38. MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

Author

Munkhbaatar, E, Dietzen, M, Agrawal, D, Anton, M, Jesinghaus, M, Boxberg, M, Pfarr, N, Bidola, P, Uhrig, S, Hoeckendorf, U, Meinhardt, A-L, Wahida, A, Heid, I, Braren, R, Mishra, R, Warth, A, Muley, T, Poh, PSP, Wang, X, Froehling, S, Steiger, K, Slotta-Huspenina, J, van Griensven, M, Pfeiffer, F, Lange, S, Rad, R, Spella, M, Stathopoulos, GT, Ruland, J, Bassermann, F, Weichert, W, Strasser, A, Branca, C, Heikenwalder, M, Swanton, C, McGranahan, N, Jost, PJ, Munkhbaatar, E, Dietzen, M, Agrawal, D, Anton, M, Jesinghaus, M, Boxberg, M, Pfarr, N, Bidola, P, Uhrig, S, Hoeckendorf, U, Meinhardt, A-L, Wahida, A, Heid, I, Braren, R, Mishra, R, Warth, A, Muley, T, Poh, PSP, Wang, X, Froehling, S, Steiger, K, Slotta-Huspenina, J, van Griensven, M, Pfeiffer, F, Lange, S, Rad, R, Spella, M, Stathopoulos, GT, Ruland, J, Bassermann, F, Weichert, W, Strasser, A, Branca, C, Heikenwalder, M, Swanton, C, McGranahan, N, and Jost, PJ

Abstract

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role of pro-survival genes in cancer cell integrity during clonal evolution in non-small cell lung cancer (NSCLC). We identify gains of MCL-1 at high frequency in multiple independent NSCLC cohorts, occurring both clonally and subclonally. Clonal loss of functional TP53 is significantly associated with subclonal gains of MCL-1. In mice, tumour progression is delayed upon pharmacologic or genetic inhibition of MCL-1. These findings reveal that MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.

Published
2020

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