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154 results on '"van Grevenstein, Wilhelmina M. U."'

1. Towards Equal Access to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy and Survival in Patients with Isolated Colorectal Peritoneal Metastases: A Nationwide Population-Based Study

Author

van der Ven, Roos G. F. M., van den Heuvel, Teun B. M., Rovers, Koen P. B., Nienhuijs, Simon W., Boerma, Djamila, van Grevenstein, Wilhelmina M. U., Hemmer, Patrick H. J., Kok, Niels F. M., Madsen, Eva V. E., de Reuver, Philip, Tuynman, Jurriaan B., van Erning, Felice N., and de Hingh, Ignace H. J. T.

Published
2024
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2. ASO Visual Abstract: Towards Equal Access to Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy and Survival in Patients with Isolated Colorectal Peritoneal Metastases—A Nationwide Population-Based Study

Author

van der Ven, Roos G. F. M., van den Heuvel, Teun B. M., Rovers, Koen P. B., Nienhuijs, Simon W., Boerma, Djamila, van Grevenstein, Wilhelmina M. U., Hemmer, Patrick H. J., Kok, Niels F. M., Madsen, Eva V. E., de Reuver, Philip, Tuynman, Jurriaan B., van Erning, Felice N., and de Hingh, Ignace H. J. T.

Published
2024
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3. Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Author

Zwart, Koen, van der Baan, Frederieke H., Punt, Cornelis J. A., Wensink, G. Emerens, Bolhuis, Karen, Laclé, Miangela M., van Grevenstein, Wilhelmina M. U., Hagendoorn, Jeroen, de Hingh, Ignace H., Koopman, Miriam, Vink, Geraldine, and Roodhart, Jeanine

Published
2023
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4. Towards patient-led follow-up after curative surgical resection of stage I, II and III colorectal cancer (DISTANCE-trial): a study protocol for a stepped-wedge cluster-randomised trial

Author

Swartjes, Hidde, Qaderi, Seyed M., Teerenstra, Steven, Custers, Jose A. E., Elferink, Marloes A. G., van Wely, Bob J., Burger, Jacobus W. A., van Grevenstein, Wilhelmina M. U., van Duijvendijk, Peter, Verdaasdonk, Emiel G. G., de Roos, Marnix A. J., Coupé, Veerle M. H., Vink, Geraldine R., Verhoef, Cornelis, and de Wilt, Johannes H. W.

Published
2023
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5. ASO Visual Abstract: Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Author

Zwart, Koen, van der Baan, Frederieke H., Punt, Cornelis J. A., Wensink, G. Emerens, Bolhuis, Karen, Laclé, Miangela M., van Grevenstein, Wilhelmina M. U., Hagendoorn, Jeroen, de Hingh, Ignace H., Koopman, Miriam, Vink, Geraldine, and Roodhart, Jeanine

Published
2023
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6. Colonoscopic-Assisted Laparoscopic Wedge Resection for Colonic Lesions: A Prospective Multicentre Cohort Study (LIMERIC-Study)

Author

Leicher, Laura W., Huisman, Jelle F., van Grevenstein, Wilhelmina M. U., Didden, Paul, Backes, Yara, Offerhaus, G. Johan A., Laclé, Miangela M., Moll, Freek C. P., Geesing, Joost M. J., Smakman, Niels, Droste, Jochim S. Terhaar Sive, Verdaasdonk, Emiel G. G., ter Borg, Frank, Talsma, A. Koen, Erkelens, G. Willemien, van der Zaag, Edwin S., Schrauwen, Ruud W. M., van Wely, Bob J., Schot, Ingrid, Vermaas, Maarten, van Bergeijk, Jeroen D., Sietses, Colin, Hazen, Wouter L., Wasowicz, Dareczka K., Ramsoekh, Dewkoemar, Tuynman, Jurriaan B., Alderlieste, Yasser A., Renger, Rutger-Jan, Oort, Frank A., Bilgen, Ernst Jan Spillenaar, Vleggaar, Frank P., Vasen, Hans F. A., Cappel, Wouter H. de Vos tot Nederveen, Moons, Leon M. G., and van Westreenen, Henderik L.

Published
2022
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7. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial

Author

Andeweg, Caroline S., Bastiaenen, Vivian P., Bemelman, Willem A., van der Bilt, Jarmila D.W., Bloemen, Johanne, den Boer, Frank C., Boerma, Djamila, ten Bokkel Huinink, Daan, Brokelman, Walter J.A., Cense, Huib A., Consten, Esther C.J., Creemers, Geert-Jan, Crolla, Rogier M.P.H., Dekker, Jan-Willem T., Demelinne, Jennifer, van Det, Marc J., van Diepen, Karin K., Diepeveen, Marjolein, van Duyn, Eino B., van den Ende, Esther D., Evers, Pauline, van Geloven, Anna A.W., van der Harst, Erwin, Heemskerk, Jeroen, Heikens, Joost T., Hess, Daniel A., Inberg, Bas, Jansen, Jan, Kloppenberg, Frank W.H., Kootstra, Thomas J.M., Kortekaas, R.T.J., Los, Maartje, Madsen, Eva V.E., van der Mijle, H.C.J., Mol, Linda, Neijenhuis, Peter A., Nienhuijs, Simon W., van den Nieuwenhof, Loes, Peeters, Koen C.M.J., Polle, Sebastiaan W., Pon, Jolien, Poortman, Pieter, Radema, Sandra A., van Ramshorst, Bert, de Reuver, Philip R., Rovers, Koen P., Schmitz, Roderick F., Sluiter, Nina, Sommeijer, Dirkje W., Sonneveld, D.J.A., van Sprundel, T.C., Veltkamp, Sanne C., Vermaas, Maarten, Verwaal, Victor J., Wassenaar, Emma, Wegdam, Johannes A., de Wilt, Johannes H.W., Westerterp, Marinke, Wit, Fennie, Witkamp, Arjen J., van Woensdregt, Karlijn, van der Zaag, Edwin S., Zournas, Mandy, Klaver, Charlotte E L, Wisselink, Daniel D, Punt, Cornelis J A, Snaebjornsson, Petur, Crezee, Johannes, Aalbers, Arend G J, Brandt, Alexandra, Bremers, Andre J A, Burger, Jacobus W A, Fabry, Hans F J, Ferenschild, Floris, Festen, Sebastiaan, van Grevenstein, Wilhelmina M U, Hemmer, Patrick H J, de Hingh, Ignace H J T, Kok, Niels F M, Musters, Gijsbert D, Schoonderwoerd, Lotte, Tuynman, Jurriaan B, van de Ven, Anthony W H, van Westreenen, Henderik L, Wiezer, Marinus J, Zimmerman, David D E, van Zweeden, Annette A, Dijkgraaf, Marcel G W, and Tanis, Pieter J

Published
2019
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8. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Hop, WC, Opmeer, BC, Reitsma, JB, Scholte, RA, Waltmann, EWH, Legemate, DA, Bartelsman, JF, Meijer, DW, Ünlü, Ç, Kluit, AB, El-Massoudi, Y, Vuylsteke, RJCLM, Tanis, PJ, Matthijsen, R, Polle, SW, Lagarde, SM, Gisbertz, SS, Wijers, O, van der Bilt, JDW, Boermeester, MA, Blom, R, Gooszen, JAH, Schreinemacher, MHF, van der Zande, T, Leeuwenburgh, MMN, Bartels, SAL, Hesp, WLEM, Koet, L, van der Schelling, GP, van Dessel, E, van Zeeland, MLP, Lensvelt, MMA, Nijhof, H, Verest, S, Buijs, M, Wijsman, JH, Stassen, LPS, Klinkert, M, de Maat, MFG, Sellenraad, G, Jeekel, J, Kleinrensink, GJ, Tha-In, T, Nijboer, WN, Boom, MJ, Verbeek, PCM, Sietses, C, Stommel, MWJ, van Huijstee, PJ, Merkus, JWS, Eefting, D, Mieog, JSD, van Geldere, D, Patijn, GA, de Vries, M, Boskamp, M, Bentohami, A, Bijlsma, TS, de Korte, N, Nio, D, Rijna, H, Luttikhold, J, van Gool, MH, Fekkes, JF, Akkersdijk, GJM, Heuff, G, Jutte, EH, Kortmann, BA, Werkman, JM, Laméris, W, Rietbergen, L, Frankenmolen, P, Draaisma, WA, Stam, MAW, Verweij, MS, Karsten, TM, de Nes, LC, Fortuin, S, de Castro, SM, Doeksen, A, Simons, MP, Koffeman, GI, Steller, EP, Tuynman, JB, Boele van Hensbroek, P, Mok, M, van Diepen, SR, Hulsewé, KWE, Melenhorst, J, Stoot, JHMB, Fransen, S, Sosef, MN, van Bastelaar, J, Vissers, YLJ, Douchy, TPD, Christiaansen, CE, Smeenk, R, Pijnenburg, AM, Tanaydin, V, Veger, HTC, Clermonts, SHEM, Al-Taher, M, de Graaf, EJR, Menon, AG, Vermaas, M, Cense, HA, Jutte, E, Wiezer, MJ, Smits, AB, Westerterp, M, Marsman, HA, Hendriks, ER, van Ruler, O, Vriens, EJC, Vogten, JM, van Rossem, CC, Ohanis, D, Tanis, E, van Grinsven, J, Maring, JK, Heisterkamp, J, Besselink, MGH, Borel Rinkes, IHM, Molenaar, IQ, Joosten, JJA, Jongkind, V, Diepenhorst, GMP, Boute, MC, Smeenge, M, Nielsen, K, Harlaar, JJ, Luyer, MDP, van Montfort, G, Smulders, JF, Daams, F, van Haren, E, Nieuwenhuijzen, GAP, Lauret, GJ, Pereboom, ITA, Stokmans, RA, Birindelli, A, Bianchi, E, Pellegrini, S, Terrasson, I, Wolthuis, A, de Buck van Overstraeten, A, Nijs, S, Lambrichts, Daniël P V, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Hoofwijk, Anton G M, Belgers, Eric H J, Stockmann, Hein B A C, Eijsbouts, Quirijn A J, Gerhards, Michael F, van Wagensveld, Bart A, van Geloven, Anna A W, Crolla, Rogier M P H, Nienhuijs, Simon W, Govaert, Marc J P M, di Saverio, Salomone, D'Hoore, André J L, Consten, Esther C J, van Grevenstein, Wilhelmina M U, Pierik, Robert E G J M, Kruyt, Philip M, van der Hoeven, Joost A B, Steup, Willem H, Catena, Fausto, Konsten, Joop L M, Vermeulen, Jefrey, van Dieren, Susan, Bemelman, Willem A, and Lange, Johan F

Published
2019
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9. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

Manusama, Eric R, Hadithi, Mohammed, Rosman, Camiel, Schaapherder, Alexander F, Schoon, Erik J, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C, Bakker, Olaf J, Besselink, Marc G, Boermeester, Marja A, Bollen, Thomas L, Bosscha, Koop, Bouwense, Stefan A, Bruno, Marco J, Cappendijk, Vincent C, Consten, Esther C, Dejong, Cornelis H, van Eijck, Casper H, Erkelens, Willemien G, van Goor, Harry, van Grevenstein, Wilhelmina M U, Haveman, Jan-Willem, Hofker, Sijbrand H, Jansen, Jeroen M, Laméris, Johan S, van Lienden, Krijn P, Meijssen, Maarten A, Mulder, Chris J, Nieuwenhuijs, Vincent B, Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J, Römkens, Tessa E, Scheepers, Joris J, Schepers, Nicolien J, Schwartz, Matthijs P, Seerden, Tom, Spanier, B W Marcel, Straathof, Jan Willem A, Strijker, Marin, Timmer, Robin, Venneman, Niels G, Vleggaar, Frank P, Voermans, Rogier P, Witteman, Ben J, Gooszen, Hein G, Dijkgraaf, Marcel G, and Fockens, Paul

Published
2018
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10. Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial

Author

Verweij, Maaike E, primary, Tanaka, Max D, additional, Kensen, Chavelli M, additional, van der Heide, Uulke A, additional, Marijnen, Corrie A M, additional, Janssen, Tomas, additional, Vijlbrief, Tineke, additional, van Grevenstein, Wilhelmina M U, additional, Moons, Leon M G, additional, Koopman, Miriam, additional, Lacle, Miangela M, additional, Braat, Manon N G J A, additional, Chalabi, Myriam, additional, Maas, Monique, additional, Huibregtse, Inge L, additional, Snaebjornsson, Petur, additional, Grotenhuis, Brechtje A, additional, Fijneman, Remond, additional, Consten, Esther, additional, Pronk, Apollo, additional, Smits, Anke B, additional, Heikens, Joost T, additional, Eijkelenkamp, Hidde, additional, Elias, Sjoerd G, additional, Verkooijen, Helena M, additional, Schoenmakers, Maartje M C, additional, Meijer, Gert J, additional, Intven, Martijn, additional, and Peters, Femke P, additional

Published
2023
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12. Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

Author

de Mul, Nikki, primary, Verlaan, Diede, additional, Ruurda, Jelle P, additional, van Grevenstein, Wilhelmina M U, additional, Hagendoorn, Jeroen, additional, de Borst, Gert-Jan, additional, Vriens, Menno R, additional, de Bree, Remco, additional, Zweemer, Ronald P, additional, Vogely, Charles, additional, Haitsma Mulier, Jelle L G, additional, Vernooij, Lisette M, additional, Reitsma, Johannes B, additional, de Zoete, Marcel R, additional, Top, Janetta, additional, Kluijtmans, Jan A J, additional, Hoefer, Imo E, additional, Noordzij, Peter, additional, Rettig, Thijs, additional, Marsman, Marije, additional, de Smet, Anne Marie G A, additional, Derde, Lennie, additional, van Waes, Judith, additional, Rijsdijk, Mienke, additional, Schellekens, Willem Jan M, additional, Bonten, Marc J M, additional, Slooter, Arjen J C, additional, and Cremer, Olaf L, additional

Published
2023
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13. ASO Visual Abstract: Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Author

Onderzoek Medische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Unit Opleiding Aios, Pathologie Pathologen staf, MS CGO, MS Medische Oncologie, Zwart, Koen, van der Baan, Frederieke H, Punt, Cornelis J A, Wensink, G Emerens, Bolhuis, Karen, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Hingh, Ignace H, Koopman, Miriam, Vink, Geraldine, Roodhart, Jeanine, Onderzoek Medische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Unit Opleiding Aios, Pathologie Pathologen staf, MS CGO, MS Medische Oncologie, Zwart, Koen, van der Baan, Frederieke H, Punt, Cornelis J A, Wensink, G Emerens, Bolhuis, Karen, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Hingh, Ignace H, Koopman, Miriam, Vink, Geraldine, and Roodhart, Jeanine

Published
2023

14. Survival of Patients with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer Receiving Curative-Intent Local Treatment of Metastases in a Nationwide Cohort

Author

Onderzoek Medische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Researchgr. Nucleaire Geneeskunde, Epi Kanker Team B, Unit Opleiding Aios, Pathologie Pathologen staf, MS CGO, MS Medische Oncologie, Zwart, Koen, van der Baan, Frederieke H, Punt, Cornelis J A, Wensink, G Emerens, Bolhuis, Karen, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Hingh, Ignace H, Koopman, Miriam, Vink, Geraldine, Roodhart, Jeanine, Onderzoek Medische Oncologie, Cancer, JC onderzoeksprogramma Kanker, Researchgr. Nucleaire Geneeskunde, Epi Kanker Team B, Unit Opleiding Aios, Pathologie Pathologen staf, MS CGO, MS Medische Oncologie, Zwart, Koen, van der Baan, Frederieke H, Punt, Cornelis J A, Wensink, G Emerens, Bolhuis, Karen, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Hingh, Ignace H, Koopman, Miriam, Vink, Geraldine, and Roodhart, Jeanine

Published
2023

15. Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial

Author

Trialbureau Beeld, Cancer, MS CGO, MS MDL 1, MS Medische Oncologie, Pathologie Pathologen staf, MS Radiologie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, MS Radiotherapie, Verweij, Maaike E, Tanaka, Max D, Kensen, Chavelli M, van der Heide, Uulke A, Marijnen, Corrie A M, Janssen, Tomas, Vijlbrief, Tineke, van Grevenstein, Wilhelmina M U, Moons, Leon M G, Koopman, Miriam, Lacle, Miangela M, Braat, Manon N G J A, Chalabi, Myriam, Maas, Monique, Huibregtse, Inge L, Snaebjornsson, Petur, Grotenhuis, Brechtje A, Fijneman, Remond, Consten, Esther, Pronk, Apollo, Smits, Anke B, Heikens, Joost T, Eijkelenkamp, Hidde, Elias, Sjoerd G, Verkooijen, Helena M, Schoenmakers, Maartje M C, Meijer, Gert J, Intven, Martijn, Peters, Femke P, Trialbureau Beeld, Cancer, MS CGO, MS MDL 1, MS Medische Oncologie, Pathologie Pathologen staf, MS Radiologie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, MS Radiotherapie, Verweij, Maaike E, Tanaka, Max D, Kensen, Chavelli M, van der Heide, Uulke A, Marijnen, Corrie A M, Janssen, Tomas, Vijlbrief, Tineke, van Grevenstein, Wilhelmina M U, Moons, Leon M G, Koopman, Miriam, Lacle, Miangela M, Braat, Manon N G J A, Chalabi, Myriam, Maas, Monique, Huibregtse, Inge L, Snaebjornsson, Petur, Grotenhuis, Brechtje A, Fijneman, Remond, Consten, Esther, Pronk, Apollo, Smits, Anke B, Heikens, Joost T, Eijkelenkamp, Hidde, Elias, Sjoerd G, Verkooijen, Helena M, Schoenmakers, Maartje M C, Meijer, Gert J, Intven, Martijn, and Peters, Femke P

Published
2023

16. Timing of rectal cancer surgery after short-course radiotherapy: national database study

Author

Cancer, Trialbureau Beeld, MS CGO, MS Radiotherapie, Verweij, Maaike E, Franzen, Jolien, van Grevenstein, Wilhelmina M U, Verkooijen, Helena M, Intven, Martijn P W, Cancer, Trialbureau Beeld, MS CGO, MS Radiotherapie, Verweij, Maaike E, Franzen, Jolien, van Grevenstein, Wilhelmina M U, Verkooijen, Helena M, and Intven, Martijn P W

Published
2023

17. Cohort profile of PLUTO: a perioperative biobank focusing on prediction and early diagnosis of postoperative complications

Author

AIOS Anesthesiologie, Epi Infectieziekten Team 1, Infection & Immunity, MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, MS Hoofd-Hals Chirurgische Oncologie, MS Gynaecologische Oncologie, MS Orthopaedie Algemeen, Onderzoek, Epi Methoden Team 4, JC onderzoeksprogramma Methodology, MMB Research line 2, Medische Microbiologie, JC onderzoeksprogramma Infectious Diseases, Centraal Diagnostisch Laboratorium, Medische staf Anesthesiologie, DVF Medisch, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, AIOS Psychiatrie, Brain, de Mul, Nikki, Verlaan, Diede, Ruurda, Jelle P, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Borst, Gert-Jan, Vriens, Menno R, de Bree, Remco, Zweemer, Ronald P, Vogely, Charles, Haitsma Mulier, Jelle L G, Vernooij, Lisette M, Reitsma, Johannes B, de Zoete, Marcel R, Top, Janetta, Kluijtmans, Jan A J, Hoefer, Imo E, Noordzij, Peter, Rettig, Thijs, Marsman, Marije, de Smet, Anne Marie G A, Derde, Lennie, van Waes, Judith, Rijsdijk, Mienke, Schellekens, Willem Jan M, Bonten, Marc J M, Slooter, Arjen J C, Cremer, Olaf L, AIOS Anesthesiologie, Epi Infectieziekten Team 1, Infection & Immunity, MS CGO, Cancer, Zorgeenheid Vaatchirurgie Medisch, Circulatory Health, Regenerative Medicine and Stem Cells, Heelkunde Opleiding, MS Hoofd-Hals Chirurgische Oncologie, MS Gynaecologische Oncologie, MS Orthopaedie Algemeen, Onderzoek, Epi Methoden Team 4, JC onderzoeksprogramma Methodology, MMB Research line 2, Medische Microbiologie, JC onderzoeksprogramma Infectious Diseases, Centraal Diagnostisch Laboratorium, Medische staf Anesthesiologie, DVF Medisch, Medische Staf Intensive Care, Epi Infectieziekten, Epidemiology of Sepsis & Inflammation in Critically Ill Patients, AIOS Psychiatrie, Brain, de Mul, Nikki, Verlaan, Diede, Ruurda, Jelle P, van Grevenstein, Wilhelmina M U, Hagendoorn, Jeroen, de Borst, Gert-Jan, Vriens, Menno R, de Bree, Remco, Zweemer, Ronald P, Vogely, Charles, Haitsma Mulier, Jelle L G, Vernooij, Lisette M, Reitsma, Johannes B, de Zoete, Marcel R, Top, Janetta, Kluijtmans, Jan A J, Hoefer, Imo E, Noordzij, Peter, Rettig, Thijs, Marsman, Marije, de Smet, Anne Marie G A, Derde, Lennie, van Waes, Judith, Rijsdijk, Mienke, Schellekens, Willem Jan M, Bonten, Marc J M, Slooter, Arjen J C, and Cremer, Olaf L

Published
2023

18. Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Author

Rovers, Koen P., Bakkers, Checca, Simkens, Geert A. A. M., Burger, Jacobus W. A., Nienhuijs, Simon W., Creemers, Geert-Jan M., Thijs, Anna M. J., Brandt-Kerkhof, Alexandra R. M., Madsen, Eva V. E., Ayez, Ninos, de Boer, Nadine L., van Meerten, Esther, Tuynman, Jurriaan B., Kusters, Miranda, Sluiter, Nina R., Verheul, Henk M. W., van der Vliet, Hans J., Wiezer, Marinus J., Boerma, Djamila, Wassenaar, Emma C. E., Los, Maartje, Hunting, Cornelis B., Aalbers, Arend G. J., Kok, Niels F. M., Kuhlmann, Koert F. D., Boot, Henk, Chalabi, Myriam, Kruijff, Schelto, Been, Lukas B., van Ginkel, Robert J., de Groot, Derk Jan A., Fehrmann, Rudolf S. N., de Wilt, Johannes H. W., Bremers, Andreas J. A., de Reuver, Philip R., Radema, Sandra A., Herbschleb, Karin H., van Grevenstein, Wilhelmina M. U., Witkamp, Arjen J., Koopman, Miriam, Haj Mohammad, Nadia, van Duyn, Eino B., Mastboom, Walter J. B., Mekenkamp, Leonie J. M., Nederend, Joost, Lahaye, Max J., Snaebjornsson, Petur, Verhoef, Cornelis, van Laarhoven, Hanneke W. M., Zwinderman, Aeilko H., Bouma, Jeanette M., Kranenburg, Onno, van ‘t Erve, Iris, Fijneman, Remond J. A., Dijkgraaf, Marcel G. W., Hemmer, Patrick H. J., Punt, Cornelis J. A., Tanis, Pieter J., and de Hingh, Ignace H. J. T.

Published
2019
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19. Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; the COLOPEC 2 randomized multicentre trial

Author

Bastiaenen, Vivian P., Klaver, Charlotte E. L., Kok, Niels F. M., de Wilt, Johannes H. W., de Hingh, Ignace H. J. T., Aalbers, Arend G. J., Boerma, Djamila, Bremers, Andre J. A., Burger, Jacobus W. A., van Duyn, Eino B., Evers, Pauline, van Grevenstein, Wilhelmina M. U., Hemmer, Patrick H. J., Madsen, Eva V. E., Snaebjornsson, Petur, Tuynman, Jurriaan B., Wiezer, Marinus J., Dijkgraaf, Marcel G. W., van der Bilt, Jarmila D. W., and Tanis, Pieter J.

Published
2019
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20. Patient‐ and physician‐reported radiation‐induced toxicity of short‐course radiotherapy with a prolonged interval to surgery for rectal cancer

Author

Verweij, Maaike E., primary, Hoendervangers, Sieske, additional, von Hebel, Charlotte M., additional, Pronk, Apollo, additional, Schiphorst, Anandi H. W., additional, Consten, Esther C. J., additional, Smits, Anke B., additional, Heikens, Joost T., additional, Verdaasdonk, Emiel G. G., additional, Rozema, Tom, additional, Verkooijen, Helena M., additional, van Grevenstein, Wilhelmina M. U., additional, and Intven, Martijn P. W., additional

Published
2022
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21. Erratum: Impact of surgical versus endoscopic management of complex nonmalignant polyps in a colorectal cancer screening program (Endoscopy DOI: 10.1055/a-1726-9144)

Author

MS CGO, Cancer, Buskermolen, Maaike, Naber, Steffie K, Toes-Zoutendijk, Esther, van der Meulen, Miriam P, van Grevenstein, Wilhelmina M U, van Leerdam, Monique E, Spaander, Manon C W, Lansdorp-Vogelaar, Iris, MS CGO, Cancer, Buskermolen, Maaike, Naber, Steffie K, Toes-Zoutendijk, Esther, van der Meulen, Miriam P, van Grevenstein, Wilhelmina M U, van Leerdam, Monique E, Spaander, Manon C W, and Lansdorp-Vogelaar, Iris

Published
2022

22. Impact of surgical versus endoscopic management of complex nonmalignant polyps in a colorectal cancer screening program

Author

MS CGO, Cancer, Buskermolen, Maaike, Naber, Steffie K, Toes-Zoutendijk, Esther, van der Meulen, Miriam P, van Grevenstein, Wilhelmina M U, van Leerdam, Monique E, Spaander, Manon C W, Lansdorp-Vogelaar, Iris, MS CGO, Cancer, Buskermolen, Maaike, Naber, Steffie K, Toes-Zoutendijk, Esther, van der Meulen, Miriam P, van Grevenstein, Wilhelmina M U, van Leerdam, Monique E, Spaander, Manon C W, and Lansdorp-Vogelaar, Iris

Published
2022

23. Colonoscopic-Assisted Laparoscopic Wedge Resection for Colonic Lesions: A Prospective Multicenter Cohort Study (LIMERIC-Study)

Author

Unit Opleiding MDL, Cancer, MS CGO, MS MDL 1, Pathologie Pathologen staf, CTC, Other research (not in main researchprogram), Leicher, Laura W, Huisman, Jelle F, van Grevenstein, Wilhelmina M U, Didden, Paul, Backes, Yara, Offerhaus, G Johan A, Laclé, Miangela M, Moll, Freek C P, Geesing, Joost M J, Smakman, Niels, Droste, Jochim S Terhaar Sive, Verdaasdonk, Emiel G G, Ter Borg, Frank, Talsma, A Koen, Erkelens, G Willemien, van der Zaag, Edwin S, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, van Bergeijk, Jeroen D, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Oort, Frank A, Bilgen, Ernst Jan Spillenaar, Vleggaar, Frank P, Vasen, Hans F A, Cappel, Wouter H de Vos Tot Nederveen, Moons, Leon M G, van Westreenen, Henderik L, Unit Opleiding MDL, Cancer, MS CGO, MS MDL 1, Pathologie Pathologen staf, CTC, Other research (not in main researchprogram), Leicher, Laura W, Huisman, Jelle F, van Grevenstein, Wilhelmina M U, Didden, Paul, Backes, Yara, Offerhaus, G Johan A, Laclé, Miangela M, Moll, Freek C P, Geesing, Joost M J, Smakman, Niels, Droste, Jochim S Terhaar Sive, Verdaasdonk, Emiel G G, Ter Borg, Frank, Talsma, A Koen, Erkelens, G Willemien, van der Zaag, Edwin S, Schrauwen, Ruud W M, van Wely, Bob J, Schot, Ingrid, Vermaas, Maarten, van Bergeijk, Jeroen D, Sietses, Colin, Hazen, Wouter L, Wasowicz, Dareczka K, Ramsoekh, Dewkoemar, Tuynman, Jurriaan B, Alderlieste, Yasser A, Renger, Rutger-Jan, Oort, Frank A, Bilgen, Ernst Jan Spillenaar, Vleggaar, Frank P, Vasen, Hans F A, Cappel, Wouter H de Vos Tot Nederveen, Moons, Leon M G, and van Westreenen, Henderik L

Published
2022

24. External validation of the MSKCC nomogram to estimate five-year overall survival after surgery for stage I–III colon cancer in a Dutch population

Author

Bond, Marinde J. G., primary, Hamers, Patricia A. H., additional, Vink, Geraldine R., additional, van Grevenstein, Wilhelmina M. U., additional, Laclé, Miangela M., additional, van Smeden, Maarten, additional, Koopman, Miriam, additional, Roodhart, Jeanine M. L., additional, Punt, Cornelis J. A., additional, and May, Anne M., additional

Published
2022
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27. Patient‐ and physician‐reported radiation‐induced toxicity of short‐course radiotherapy with a prolonged interval to surgery for rectal cancer.

Author

Verweij, Maaike E., Hoendervangers, Sieske, von Hebel, Charlotte M., Pronk, Apollo, Schiphorst, Anandi H. W., Consten, Esther C. J., Smits, Anke B., Heikens, Joost T., Verdaasdonk, Emiel G. G., Rozema, Tom, Verkooijen, Helena M., van Grevenstein, Wilhelmina M. U., and Intven, Martijn P. W.

Subjects
RECTAL cancer, RECTAL surgery, RADIOTHERAPY complications, RADIOTHERAPY, ONCOLOGIC surgery, PATIENTS' attitudes
Abstract

Aim: A prolonged interval (>4 weeks) between short‐course radiotherapy (25 Gy in five fractions) (SCRT‐delay) and total mesorectal excision for rectal cancer has been associated with a decreased postoperative complication rate and offers the possibility of organ preservation in the case of a complete tumour response. This prospective cohort study systematically evaluated patient‐reported bowel dysfunction and physician‐reported radiation‐induced toxicity for 8 weeks following SCRT‐delay. Method: Patients who were referred for SCRT‐delay for intermediate risk, oligometastatic or locally advanced rectal cancer were included. Repeated measurements were done for patient‐reported bowel dysfunction (measured by the low anterior resection syndrome [LARS] questionnaire and categorized as no, minor or major LARS) and physician‐reported radiation‐induced toxicity (according to Common Terminology Criteria for Adverse Events version 4.0) before start of treatment (baseline), at completion of SCRT and 1, 2, 3, 4, 6 and 8 weeks thereafter. Results: Fifty‐one patients were included; 31 (61%) were men and the median age was 67 years (range 44–91). Patient‐reported bowel dysfunction and physician‐reported radiation‐induced toxicity peaked at weeks 1–2 after completion of SCRT and gradually declined thereafter. Major LARS was reported by 44 patients (92%) at some time during SCRT‐delay. Grade 3 radiation‐induced toxicity was reported in 17 patients (33%) and concerned predominantly diarrhoea. No Grade 4–5 radiation‐induced toxicity occurred. Conclusion: During SCRT‐delay, almost every patient experiences temporary mild–moderate radiation‐induced toxicity and major LARS, but life‐threatening toxicity is rare. SCRT‐delay is a safe alternative to SCRT‐direct surgery that should be proposed when counselling rectal cancer patients on neoadjuvant strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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28. The Prospective Dutch Colorectal Cancer (PLCRC) cohort: real-world data facilitating research and clinical care

Author

Derksen, Jeroen W. G., Vink, Geraldine R., Elferink, Marloes A. G., Roodhart, Jeanine M. L., Verkooijen, Helena M., van Grevenstein, Wilhelmina M. U., Siersema, Peter D., May, Anne M., Koopman, Miriam, Beets, Geerard L., Belt, Eric J. Th., Berbée, Maaike, Beverdam, Frederique H., Blankenburgh, Ruud, Coene, Peter Paul L. O., van Cruijsen, Hester, Dekker, Jan Willem T., van Dodewaard-de Jong, Joyce M., Erdkamp, Frans L. G., de Groot, Jan Willem B., Haringhuizen, Annebeth W., Helgason, Helgi H., Hendriks, Mathijs P., de Hingh, Ignace H. J. T., Hoekstra, Ronald, Ijzermans, Jan N. M., Jansen, Jan, Kloppenberg, Frank W. H., van Lent, Anja U. G., Los, Maartje, Meijerink, Martijn R., Mekenkamp, Leonie J. M., Nieboer, Peter, Peeters, Koen C. M. J., Peters, Natascha A. J. B., Polée, Marco B., Pruijt, Johannes F. M., Punt, Cornelis J. A., van Ufford-Mannesse, Patricia Quarles, Rietbroek, Ron C., Schiphorst, Anandi H. W., van der Velden, Arjan Schouten, Schrauwen, Ruud W. M., Sie, Mark P. S., Simkens, Lieke, Sommeijer, Dirkje W., Sonneveld, Dirk J. A., Spierings, Leontine E. A., Stockmann, Hein B. A. C., Talsma, Koen, Terheggen, Frederiek, ten Tije, Albert J., Tjin-A-Ton, Manuel L. R., Valkenburg-van Iersel, Liselot B. J., Veenstra, Renzo P., van der Velden, Ankie M. T., Vermaas, Maarten, Vles, Wouter J., Vogelaar, Jeroen F. J., van Voorthuizen, Theo, de Vos, Aad I., Wegdam, Johannes A., de Wilt, Johannes H. W., Zimmerman, David D. E., Surgery, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Epidemiologie, CCA - Cancer Treatment and quality of life, Radiology and nuclear medicine, Internal medicine, and VU University medical center

Subjects
Male, medicine.medical_specialty, Colorectal cancer, Epidemiology, Science, Population, MODELS, MEDLINE, Logistic regression, Representativeness heuristic, Article, 03 medical and health sciences, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], 0302 clinical medicine, Cancer epidemiology, Medical research, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Multidisciplinary approach, COLON, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Registries, education, Aged, Netherlands, Aged, 80 and over, education.field_of_study, Multidisciplinary, business.industry, Middle Aged, medicine.disease, Cancer registry, TRIALS, Outcomes research, 030220 oncology & carcinogenesis, Family medicine, Cohort, Medicine, Female, business, Colorectal Neoplasms
Abstract

Real-world data (RWD) sources are important to advance clinical oncology research and evaluate treatments in daily practice. Since 2013, the Prospective Dutch Colorectal Cancer (PLCRC) cohort, linked to the Netherlands Cancer Registry, serves as an infrastructure for scientific research collecting additional patient-reported outcomes (PRO) and biospecimens. Here we report on cohort developments and investigate to what extent PLCRC reflects the “real-world”. Clinical and demographic characteristics of PLCRC participants were compared with the general Dutch CRC population (n = 74,692, Dutch-ref). To study representativeness, standardized differences between PLCRC and Dutch-ref were calculated, and logistic regression models were evaluated on their ability to distinguish cohort participants from the Dutch-ref (AU-ROC 0.5 = preferred, implying participation independent of patient characteristics). Stratified analyses by stage and time-period (2013–2016 and 2017–Aug 2019) were performed to study the evolution towards RWD. In August 2019, 5744 patients were enrolled. Enrollment increased steeply, from 129 participants (1 hospital) in 2013 to 2136 (50 of 75 Dutch hospitals) in 2018. Low AU-ROC (0.65, 95% CI: 0.64–0.65) indicates limited ability to distinguish cohort participants from the Dutch-ref. Characteristics that remained imbalanced in the period 2017–Aug’19 compared with the Dutch-ref were age (65.0 years in PLCRC, 69.3 in the Dutch-ref) and tumor stage (40% stage-III in PLCRC, 30% in the Dutch-ref). PLCRC approaches to represent the Dutch CRC population and will ultimately meet the current demand for high-quality RWD. Efforts are ongoing to improve multidisciplinary recruitment which will further enhance PLCRC’s representativeness and its contribution to a learning healthcare system.

Published
2021
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29. Consensus molecular subtype 4 (CMS4)-targeted therapy in primary colon cancer: A proof-of-concept study.

Author

Peters, Niek A., Constantinides, Alexander, Ubink, Inge, van Kuik, Joyce, Bloemendal, Haiko J., van Dodewaard, Joyce M., Brink, Menno A., Schwartz, Thijs P., Lolkema, Martijn P. J. K., Lacle, Miangela M., Moons, Leon M., Geesing, Joost, van Grevenstein, Wilhelmina M. U., Roodhart, Jeanine M. L., Koopman, Miriam, Elias, Sjoerd G., Borel Rinkes, Inne H. M., and Kranenburg, Onno

Subjects
COLON cancer, GENE expression, CANCER genes, INFORMED consent (Medical law), CONSENSUS (Social sciences)
Abstract

Background: Mesenchymal Consensus Molecular Subtype 4 (CMS4) colon cancer is associated with poor prognosis and therapy resistance. In this proof-of-concept study, we assessed whether a rationally chosen drug could mitigate the distinguishing molecular features of primary CMS4 colon cancer. Methods: In the ImPACCT trial, informed consent was obtained for molecular subtyping at initial diagnosis of colon cancer using a validated RT-qPCR CMS4-test on three biopsies per tumor (Phase-1, n=69 patients), and for neoadjuvant CMS4-targeting therapy with imatinib (Phase-2, n=5). Pre- and post-treatment tumor biopsies were analyzed by RNA-sequencing and immunohistochemistry. Imatinib-induced gene expression changes were associated with molecular subtypes and survival in an independent cohort of 3232 primary colon cancer. Results: The CMS4-test classified 52/172 biopsies as CMS4 (30%). Five patients consented to imatinib treatment prior to surgery, yielding 15 pre- and 15 posttreatment samples for molecular analysis. Imatinib treatment caused significant suppression of mesenchymal genes and upregulation of genes encoding epithelial junctions. The gene expression changes induced by imatinib were associated with improved survival and a shift from CMS4 to CMS2. Conclusion: Imatinib may have value as a CMS-switching drug in primary colon cancer and induces a gene expression program that is associated with improved survival. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Efficacy of Dose-Escalated Chemoradiation on Complete Tumor Response in Patients with Locally Advanced Rectal Cancer (RECTAL-BOOST): A Phase 2 Randomized Controlled Trial

Author

Onderzoek Radiotherapie, Pathologie Pathologen staf, MS Radiologie, Arts-assistenten Radiologie, MS Medische Oncologie, Cancer, Fysica Radiotherapie Research, MS CGO, Trialbureau Beeld, Circulatory Health, JC onderzoeksprogramma Kanker, MS Radiotherapie, Couwenberg, Alice M, Burbach, Johannes P M, Berbee, Maaike, Lacle, Miangela M, Arensman, René, Raicu, Mihaela G, Wessels, Frank J, Verdult, Joanne, Roodhart, Jeanine, Reerink, Onne, Hoendervangers, Sieske, Buijsen, Jeroen, Grabsch, Heike, Pronk, Apollo, Consten, Esther Cj, Smits, Anke B, Heikens, Joost T, Appelt, Ane L, van Grevenstein, Wilhelmina M U, Verkooijen, Helena M, Intven, Martijn P W, Onderzoek Radiotherapie, Pathologie Pathologen staf, MS Radiologie, Arts-assistenten Radiologie, MS Medische Oncologie, Cancer, Fysica Radiotherapie Research, MS CGO, Trialbureau Beeld, Circulatory Health, JC onderzoeksprogramma Kanker, MS Radiotherapie, Couwenberg, Alice M, Burbach, Johannes P M, Berbee, Maaike, Lacle, Miangela M, Arensman, René, Raicu, Mihaela G, Wessels, Frank J, Verdult, Joanne, Roodhart, Jeanine, Reerink, Onne, Hoendervangers, Sieske, Buijsen, Jeroen, Grabsch, Heike, Pronk, Apollo, Consten, Esther Cj, Smits, Anke B, Heikens, Joost T, Appelt, Ane L, van Grevenstein, Wilhelmina M U, Verkooijen, Helena M, and Intven, Martijn P W

Published
2020

33. Systematic review of published literature on oxaliplatin and mitomycin C as chemotherapeutic agents for hyperthermic intraperitoneal chemotherapy in patients with peritoneal metastases from colorectal cancer

Author

Wisselink, Daan D, Braakhuis, Linde L F, Gallo, Gaetano, van Grevenstein, Wilhelmina M U, van Dieren, Susan, Kok, Niels F M, de Reuver, Philip R, Tanis, Pieter J, de Hingh, Ignace H J T, Wisselink, Daan D, Braakhuis, Linde L F, Gallo, Gaetano, van Grevenstein, Wilhelmina M U, van Dieren, Susan, Kok, Niels F M, de Reuver, Philip R, Tanis, Pieter J, and de Hingh, Ignace H J T

Published
2019

34. Systematic review of published literature on oxaliplatin and mitomycin C as chemotherapeutic agents for hyperthermic intraperitoneal chemotherapy in patients with peritoneal metastases from colorectal cancer

Author

MS CGO, Cancer, Wisselink, Daan D, Braakhuis, Linde L F, Gallo, Gaetano, van Grevenstein, Wilhelmina M U, van Dieren, Susan, Kok, Niels F M, de Reuver, Philip R, Tanis, Pieter J, de Hingh, Ignace H J T, MS CGO, Cancer, Wisselink, Daan D, Braakhuis, Linde L F, Gallo, Gaetano, van Grevenstein, Wilhelmina M U, van Dieren, Susan, Kok, Niels F M, de Reuver, Philip R, Tanis, Pieter J, and de Hingh, Ignace H J T

Published
2019

35. Improving Outcomes in Oncological Colorectal Surgery by Prehabilitation

Author

MS CGO, Cancer, Bruns, Emma R J, van Rooijen, Stefanus J, Argillander, Tanja E, van der Zaag, Edwin S, van Grevenstein, Wilhelmina M U, van Duijvendijk, Peter, Buskens, Christianne J, Bemelman, Willem A, van Munster, Barbara C, Slooter, Gerrit D, van den Heuvel, Baukje, MS CGO, Cancer, Bruns, Emma R J, van Rooijen, Stefanus J, Argillander, Tanja E, van der Zaag, Edwin S, van Grevenstein, Wilhelmina M U, van Duijvendijk, Peter, Buskens, Christianne J, Bemelman, Willem A, van Munster, Barbara C, Slooter, Gerrit D, and van den Heuvel, Baukje

Published
2019

36. Comparison of Systematic Video Documentation With Narrative Operative Report in Colorectal Cancer Surgery

Author

Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, van de Graaf, Floyd W, Lange, Marilyne M, Spakman, Jolanda I, van Grevenstein, Wilhelmina M U, Lips, Daan, de Graaf, Eelco J R, Menon, Anand G, Lange, Johan F, Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, van de Graaf, Floyd W, Lange, Marilyne M, Spakman, Jolanda I, van Grevenstein, Wilhelmina M U, Lips, Daan, de Graaf, Eelco J R, Menon, Anand G, and Lange, Johan F

Published
2019

37. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial

Author

Klaver, Charlotte E L, primary, Wisselink, Daniel D, additional, Punt, Cornelis J A, additional, Snaebjornsson, Petur, additional, Crezee, Johannes, additional, Aalbers, Arend G J, additional, Brandt, Alexandra, additional, Bremers, Andre J A, additional, Burger, Jacobus W A, additional, Fabry, Hans F J, additional, Ferenschild, Floris, additional, Festen, Sebastiaan, additional, van Grevenstein, Wilhelmina M U, additional, Hemmer, Patrick H J, additional, de Hingh, Ignace H J T, additional, Kok, Niels F M, additional, Musters, Gijsbert D, additional, Schoonderwoerd, Lotte, additional, Tuynman, Jurriaan B, additional, van de Ven, Anthony W H, additional, van Westreenen, Henderik L, additional, Wiezer, Marinus J, additional, Zimmerman, David D E, additional, van Zweeden, Annette A, additional, Dijkgraaf, Marcel G W, additional, Tanis, Pieter J, additional, Andeweg, Caroline S., additional, Bastiaenen, Vivian P., additional, Bemelman, Willem A., additional, van der Bilt, Jarmila D.W., additional, Bloemen, Johanne, additional, den Boer, Frank C., additional, Boerma, Djamila, additional, ten Bokkel Huinink, Daan, additional, Brokelman, Walter J.A., additional, Cense, Huib A., additional, Consten, Esther C.J., additional, Creemers, Geert-Jan, additional, Crolla, Rogier M.P.H., additional, Dekker, Jan-Willem T., additional, Demelinne, Jennifer, additional, van Det, Marc J., additional, van Diepen, Karin K., additional, Diepeveen, Marjolein, additional, van Duyn, Eino B., additional, van den Ende, Esther D., additional, Evers, Pauline, additional, van Geloven, Anna A.W., additional, van der Harst, Erwin, additional, Heemskerk, Jeroen, additional, Heikens, Joost T., additional, Hess, Daniel A., additional, Inberg, Bas, additional, Jansen, Jan, additional, Kloppenberg, Frank W.H., additional, Kootstra, Thomas J.M., additional, Kortekaas, R.T.J., additional, Los, Maartje, additional, Madsen, Eva V.E., additional, van der Mijle, H.C.J., additional, Mol, Linda, additional, Neijenhuis, Peter A., additional, Nienhuijs, Simon W., additional, van den Nieuwenhof, Loes, additional, Peeters, Koen C.M.J., additional, Polle, Sebastiaan W., additional, Pon, Jolien, additional, Poortman, Pieter, additional, Radema, Sandra A., additional, van Ramshorst, Bert, additional, de Reuver, Philip R., additional, Rovers, Koen P., additional, Schmitz, Roderick F., additional, Sluiter, Nina, additional, Sommeijer, Dirkje W., additional, Sonneveld, D.J.A., additional, van Sprundel, T.C., additional, Veltkamp, Sanne C., additional, Vermaas, Maarten, additional, Verwaal, Victor J., additional, Wassenaar, Emma, additional, Wegdam, Johannes A., additional, de Wilt, Johannes H.W., additional, Westerterp, Marinke, additional, Wit, Fennie, additional, Witkamp, Arjen J., additional, van Woensdregt, Karlijn, additional, van der Zaag, Edwin S., additional, and Zournas, Mandy, additional

Published
2019
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38. Hartmann's procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial

Author

Lambrichts, Daniël P V, primary, Vennix, Sandra, additional, Musters, Gijsbert D, additional, Mulder, Irene M, additional, Swank, Hilko A, additional, Hoofwijk, Anton G M, additional, Belgers, Eric H J, additional, Stockmann, Hein B A C, additional, Eijsbouts, Quirijn A J, additional, Gerhards, Michael F, additional, van Wagensveld, Bart A, additional, van Geloven, Anna A W, additional, Crolla, Rogier M P H, additional, Nienhuijs, Simon W, additional, Govaert, Marc J P M, additional, di Saverio, Salomone, additional, D'Hoore, André J L, additional, Consten, Esther C J, additional, van Grevenstein, Wilhelmina M U, additional, Pierik, Robert E G J M, additional, Kruyt, Philip M, additional, van der Hoeven, Joost A B, additional, Steup, Willem H, additional, Catena, Fausto, additional, Konsten, Joop L M, additional, Vermeulen, Jefrey, additional, van Dieren, Susan, additional, Bemelman, Willem A, additional, Lange, Johan F, additional, Hop, WC, additional, Opmeer, BC, additional, Reitsma, JB, additional, Scholte, RA, additional, Waltmann, EWH, additional, Legemate, DA, additional, Bartelsman, JF, additional, Meijer, DW, additional, Ünlü, Ç, additional, Kluit, AB, additional, El-Massoudi, Y, additional, Vuylsteke, RJCLM, additional, Tanis, PJ, additional, Matthijsen, R, additional, Polle, SW, additional, Lagarde, SM, additional, Gisbertz, SS, additional, Wijers, O, additional, van der Bilt, JDW, additional, Boermeester, MA, additional, Blom, R, additional, Gooszen, JAH, additional, Schreinemacher, MHF, additional, van der Zande, T, additional, Leeuwenburgh, MMN, additional, Bartels, SAL, additional, Hesp, WLEM, additional, Koet, L, additional, van der Schelling, GP, additional, van Dessel, E, additional, van Zeeland, MLP, additional, Lensvelt, MMA, additional, Nijhof, H, additional, Verest, S, additional, Buijs, M, additional, Wijsman, JH, additional, Stassen, LPS, additional, Klinkert, M, additional, de Maat, MFG, additional, Sellenraad, G, additional, Jeekel, J, additional, Kleinrensink, GJ, additional, Tha-In, T, additional, Nijboer, WN, additional, Boom, MJ, additional, Verbeek, PCM, additional, Sietses, C, additional, Stommel, MWJ, additional, van Huijstee, PJ, additional, Merkus, JWS, additional, Eefting, D, additional, Mieog, JSD, additional, van Geldere, D, additional, Patijn, GA, additional, de Vries, M, additional, Boskamp, M, additional, Bentohami, A, additional, Bijlsma, TS, additional, de Korte, N, additional, Nio, D, additional, Rijna, H, additional, Luttikhold, J, additional, van Gool, MH, additional, Fekkes, JF, additional, Akkersdijk, GJM, additional, Heuff, G, additional, Jutte, EH, additional, Kortmann, BA, additional, Werkman, JM, additional, Laméris, W, additional, Rietbergen, L, additional, Frankenmolen, P, additional, Draaisma, WA, additional, Stam, MAW, additional, Verweij, MS, additional, Karsten, TM, additional, de Nes, LC, additional, Fortuin, S, additional, de Castro, SM, additional, Doeksen, A, additional, Simons, MP, additional, Koffeman, GI, additional, Steller, EP, additional, Tuynman, JB, additional, Boele van Hensbroek, P, additional, Mok, M, additional, van Diepen, SR, additional, Hulsewé, KWE, additional, Melenhorst, J, additional, Stoot, JHMB, additional, Fransen, S, additional, Sosef, MN, additional, van Bastelaar, J, additional, Vissers, YLJ, additional, Douchy, TPD, additional, Christiaansen, CE, additional, Smeenk, R, additional, Pijnenburg, AM, additional, Tanaydin, V, additional, Veger, HTC, additional, Clermonts, SHEM, additional, Al-Taher, M, additional, de Graaf, EJR, additional, Menon, AG, additional, Vermaas, M, additional, Cense, HA, additional, Jutte, E, additional, Wiezer, MJ, additional, Smits, AB, additional, Westerterp, M, additional, Marsman, HA, additional, Hendriks, ER, additional, van Ruler, O, additional, Vriens, EJC, additional, Vogten, JM, additional, van Rossem, CC, additional, Ohanis, D, additional, Tanis, E, additional, van Grinsven, J, additional, Maring, JK, additional, Heisterkamp, J, additional, Besselink, MGH, additional, Borel Rinkes, IHM, additional, Molenaar, IQ, additional, Joosten, JJA, additional, Jongkind, V, additional, Diepenhorst, GMP, additional, Boute, MC, additional, Smeenge, M, additional, Nielsen, K, additional, Harlaar, JJ, additional, Luyer, MDP, additional, van Montfort, G, additional, Smulders, JF, additional, Daams, F, additional, van Haren, E, additional, Nieuwenhuijzen, GAP, additional, Lauret, GJ, additional, Pereboom, ITA, additional, Stokmans, RA, additional, Birindelli, A, additional, Bianchi, E, additional, Pellegrini, S, additional, Terrasson, I, additional, Wolthuis, A, additional, de Buck van Overstraeten, A, additional, and Nijs, S, additional

Published
2019
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40. Adjuvant Hyperthermic Intraperitoneal Chemotherapy in Patients with Locally Advanced Colon Cancer; the COLOPEC Randomized Trial

Author

Klaver, Charlotte, primary, Wisselink, Daniel D., additional, Punt, Cornelis J. A., additional, Snaebjornsson, Petur, additional, Crezee, Johannes, additional, Aalbers, Arend G. J., additional, Brandt, Alexandra, additional, Bremers, Andre J. A., additional, Burger, Jacobus W. A., additional, Fabry, Hans F. J., additional, Ferenschild, Floris, additional, Festen, Sebastiaan, additional, van Grevenstein, Wilhelmina M. U., additional, Hemmer, Patrick H. J., additional, de Hingh, Ignace H. J. T., additional, Kok, Niels F. M., additional, Musters, Gijsbert D., additional, Schoonderwoerd, Lotte, additional, Tuynman, Jurriaan B., additional, van de Ven, Anthony W. H., additional, van Westreenen, Henderik. L., additional, Wiezer, Marinus J., additional, Zimmerman, David D. E., additional, van Zweeden, Annette A., additional, Dijkgraaf, Marcel G. W., additional, Tanis, Pieter J., additional, and Group, COLOPEC Collaborators, additional

Published
2019
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42. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

van Brunschot, Sandra, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M. U., Haveman, Jan-Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lameris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J., Romkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W. Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., Fockens, Paul, Dutch Pancreatitis Study Grp, van Brunschot, Sandra, van Brunschot, Sandra, van Grinsven, Janneke, van Santvoort, Hjalmar C., Bakker, Olaf J., Besselink, Marc G., Boermeester, Marja A., Bollen, Thomas L., Bosscha, Koop, Bouwense, Stefan A., Bruno, Marco J., Cappendijk, Vincent C., Consten, Esther C., Dejong, Cornelis H., van Eijck, Casper H., Erkelens, Willemien G., van Goor, Harry, van Grevenstein, Wilhelmina M. U., Haveman, Jan-Willem, Hofker, Sijbrand H., Jansen, Jeroen M., Lameris, Johan S., van Lienden, Krijn P., Meijssen, Maarten A., Mulder, Chris J., Nieuwenhuijs, Vincent B., Poley, Jan-Werner, Quispel, Rutger, de Ridder, Rogier J., Romkens, Tessa E., Scheepers, Joris J., Schepers, Nicolien J., Schwartz, Matthijs P., Seerden, Tom, Spanier, B. W. Marcel, Straathof, Jan Willem A., Strijker, Marin, Timmer, Robin, Venneman, Niels G., Vleggaar, Frank P., Voermans, Rogier P., Witteman, Ben J., Gooszen, Hein G., Dijkgraaf, Marcel G., Fockens, Paul, and Dutch Pancreatitis Study Grp

Abstract

Background Infected necrotising pancreatitis is a potentially lethal disease and an indication for invasive intervention. The surgical step-up approach is the standard treatment. A promising alternative is the endoscopic step-up approach. We compared both approaches to see whether the endoscopic step-up approach was superior to the surgical step-up approach in terms of clinical and economic outcomes. Methods In this multicentre, randomised, superiority trial, we recruited adult patients with infected necrotising pancreatitis and an indication for invasive intervention from 19 hospitals in the Netherlands. Patients were randomly assigned to either the endoscopic or the surgical step-up approach. The endoscopic approach consisted of endoscopic ultrasound-guided transluminal drainage followed, if necessary, by endoscopic necrosectomy. The surgical approach consisted of percutaneous catheter drainage followed, if necessary, by video-assisted retroperitoneal debridement. The primary endpoint was a composite of major complications or death during 6-month follow-up. Analyses were by intention to treat. Findings Between Sept 20, 2011, and Jan 29, 2015, we screened 418 patients with pancreatic or extrapancreatic necrosis, of which 98 patients were enrolled and randomly assigned to the endoscopic step-up approach (n=51) or the surgical step-up approach (n=47). The primary endpoint occurred in 22 (43%) of 51 patients in the endoscopy group and in 21 (45%) of 47 patients in the surgery group (risk ratio [RR] 0.97, 95% CI 0.62-1.51; p= 0.88). Mortality did not differ between groups (nine [18%] patients in the endoscopy group vs six [13%] patients in the surgery group; RR 1.38, 95% CI 0.53-3.59, p= 0.50), nor did any of the major complications included in the primary endpoint. Interpretation In patients with infected necrotising pancreatitis, the endoscopic step-up approach was not superior to the surgical step-up approach in reducing major complications or death. The rate of pan

Published
2018

43. Utility Scores and Preferences for Surgical and Organ-Sparing Approaches for Treatment of Intermediate and High-Risk Rectal Cancer

Author

MS Radiotherapie, Cancer, Onderzoek Radiotherapie, Trialbureau Beeld, JC onderzoeksprogramma Kanker, MS CGO, Epi Kanker Team A, Circulatory Health, Couwenberg, Alice M, Intven, Martijn P W, Burbach, Johannes P M, Emaus, Marleen J, van Grevenstein, Wilhelmina M U, Verkooijen, Helena M, MS Radiotherapie, Cancer, Onderzoek Radiotherapie, Trialbureau Beeld, JC onderzoeksprogramma Kanker, MS CGO, Epi Kanker Team A, Circulatory Health, Couwenberg, Alice M, Intven, Martijn P W, Burbach, Johannes P M, Emaus, Marleen J, van Grevenstein, Wilhelmina M U, and Verkooijen, Helena M

Published
2018

44. Effect of Neoadjuvant Therapy and Rectal Surgery on Health-related Quality of Life in Patients With Rectal Cancer During the First 2 Years After Diagnosis

Author

Onderzoek Radiotherapie, Cancer, MS CGO, MS Radiotherapie, Trialbureau Beeld, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Couwenberg, Alice M, Burbach, Johannes P M, van Grevenstein, Wilhelmina M U, Smits, Anke B, Consten, Esther C J, Schiphorst, Anandi H W, Wijffels, Niels A T, Heikens, Joost T, Intven, Martijn P W, Verkooijen, Helena M, Onderzoek Radiotherapie, Cancer, MS CGO, MS Radiotherapie, Trialbureau Beeld, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, Couwenberg, Alice M, Burbach, Johannes P M, van Grevenstein, Wilhelmina M U, Smits, Anke B, Consten, Esther C J, Schiphorst, Anandi H W, Wijffels, Niels A T, Heikens, Joost T, Intven, Martijn P W, and Verkooijen, Helena M

Published
2018

45. Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases: A Phase 2 Randomized Clinical Trial

Author

Rovers, Koen P., Bakkers, Checca, Nienhuijs, Simon W., Burger, Jacobus W. A., Creemers, Geert-Jan M., Thijs, Anna M. J., Brandt-Kerkhof, Alexandra R. M., Madsen, Eva V. E., van Meerten, Esther, Tuynman, Jurriaan B., Kusters, Miranda, Versteeg, Kathelijn S., Aalbers, Arend G. J., Kok, Niels F. M., Buffart, Tineke E., Wiezer, Marinus J., Boerma, Djamila, Los, Maartje, de Reuver, Philip R., Bremers, Andreas J. A., Verheul, Henk M. W., Kruijff, Schelto, de Groot, Derk Jan A., Witkamp, Arjen J., van Grevenstein, Wilhelmina M. U., Koopman, Miriam, Nederend, Joost, Lahaye, Max J., Kranenburg, Onno, Fijneman, Remond J. A., van ’t Erve, Iris, Snaebjornsson, Petur, Hemmer, Patrick H. J., Dijkgraaf, Marcel G. W., Punt, Cornelis J. A., Tanis, Pieter J., and de Hingh, Ignace H. J. T.

Abstract

IMPORTANCE: To date, no randomized clinical trials have investigated perioperative systemic therapy relative to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone for resectable colorectal peritoneal metastases (CPM). OBJECTIVE: To assess the feasibility and safety of perioperative systemic therapy in patients with resectable CPM and the response of CPM to neoadjuvant treatment. DESIGN, SETTING, AND PARTICIPANTS: An open-label, parallel-group phase 2 randomized clinical trial in all 9 Dutch tertiary centers for the surgical treatment of CPM enrolled participants between June 15, 2017, and January 9, 2019. Participants were patients with pathologically proven isolated resectable CPM who did not receive systemic therapy within 6 months before enrollment. INTERVENTIONS: Randomization to perioperative systemic therapy or CRS-HIPEC alone. Perioperative systemic therapy comprised either four 3-week neoadjuvant and adjuvant cycles of CAPOX (capecitabine and oxaliplatin), six 2-week neoadjuvant and adjuvant cycles of FOLFOX (fluorouracil, leucovorin, and oxaliplatin), or six 2-week neoadjuvant cycles of FOLFIRI (fluorouracil, leucovorin, and irinotecan) and either four 3-week adjuvant cycles of capecitabine or six 2-week adjuvant cycles of fluorouracil with leucovorin. Bevacizumab was added to the first 3 (CAPOX) or 4 (FOLFOX/FOLFIRI) neoadjuvant cycles. MAIN OUTCOMES AND MEASURES: Proportions of macroscopic complete CRS-HIPEC and Clavien-Dindo grade 3 or higher postoperative morbidity. Key secondary outcomes were centrally assessed rates of objective radiologic and major pathologic response of CPM to neoadjuvant treatment. Analyses were done modified intention-to-treat in patients starting neoadjuvant treatment (experimental arm) or undergoing upfront surgery (control arm). RESULTS: In 79 patients included in the analysis (43 [54%] men; mean [SD] age, 62 [10] years), experimental (n = 37) and control (n = 42) arms did not differ significantly regarding the proportions of macroscopic complete CRS-HIPEC (33 of 37 [89%] vs 36 of 42 [86%] patients; risk ratio, 1.04; 95% CI, 0.88-1.23; P = .74) and Clavien-Dindo grade 3 or higher postoperative morbidity (8 of 37 [22%] vs 14 of 42 [33%] patients; risk ratio, 0.65; 95% CI, 0.31-1.37; P = .25). No treatment-related deaths occurred. Objective radiologic and major pathologic response rates of CPM to neoadjuvant treatment were 28% (9 of 32 evaluable patients) and 38% (13 of 34 evaluable patients), respectively. CONCLUSIONS AND RELEVANCE: In this randomized phase 2 trial in patients diagnosed with resectable CPM, perioperative systemic therapy seemed feasible, safe, and able to induce response of CPM, justifying a phase 3 trial. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02758951

Published
2021
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46. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial

Author

van Brunschot, Sandra, primary, van Grinsven, Janneke, additional, van Santvoort, Hjalmar C, additional, Bakker, Olaf J, additional, Besselink, Marc G, additional, Boermeester, Marja A, additional, Bollen, Thomas L, additional, Bosscha, Koop, additional, Bouwense, Stefan A, additional, Bruno, Marco J, additional, Cappendijk, Vincent C, additional, Consten, Esther C, additional, Dejong, Cornelis H, additional, van Eijck, Casper H, additional, Erkelens, Willemien G, additional, van Goor, Harry, additional, van Grevenstein, Wilhelmina M U, additional, Haveman, Jan-Willem, additional, Hofker, Sijbrand H, additional, Jansen, Jeroen M, additional, Laméris, Johan S, additional, van Lienden, Krijn P, additional, Meijssen, Maarten A, additional, Mulder, Chris J, additional, Nieuwenhuijs, Vincent B, additional, Poley, Jan-Werner, additional, Quispel, Rutger, additional, de Ridder, Rogier J, additional, Römkens, Tessa E, additional, Scheepers, Joris J, additional, Schepers, Nicolien J, additional, Schwartz, Matthijs P, additional, Seerden, Tom, additional, Spanier, B W Marcel, additional, Straathof, Jan Willem A, additional, Strijker, Marin, additional, Timmer, Robin, additional, Venneman, Niels G, additional, Vleggaar, Frank P, additional, Voermans, Rogier P, additional, Witteman, Ben J, additional, Gooszen, Hein G, additional, Dijkgraaf, Marcel G, additional, Fockens, Paul, additional, Manusama, Eric R, additional, Hadithi, Mohammed, additional, Rosman, Camiel, additional, Schaapherder, Alexander F, additional, and Schoon, Erik J, additional

Published
2018
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48. A Novel Diagnostic Tool for Selecting Patients With Mesenchymal-Type Colon Cancer Reveals Intratumor Subtype Heterogeneity

Author

MS CGO, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Groep Van Diest, Pathologie Pathologen staf, Pathologie, Regenerative Medicine and Stem Cells, Ubink, Inge, Elias, Sjoerd G, Moelans, CB, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, van Diest, Paul J, Borel Rinkes, Inne H M, Kranenburg, OW, MS CGO, Cancer, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Pathologie Groep Van Diest, Pathologie Pathologen staf, Pathologie, Regenerative Medicine and Stem Cells, Ubink, Inge, Elias, Sjoerd G, Moelans, CB, Laclé, Miangela M, van Grevenstein, Wilhelmina M U, van Diest, Paul J, Borel Rinkes, Inne H M, and Kranenburg, OW

Published
2017

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