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2. Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma

Author

Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, Pharmaceutics, Reiniers, M J, de Haan, L, Weijer, R, Wiggers, J K, Jongejan, A, Moerland, P D, Alles, L K, van Kampen, A H C, van Gulik, T M, Heger, M, van Golen, R F, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, Pharmaceutics, Reiniers, M J, de Haan, L, Weijer, R, Wiggers, J K, Jongejan, A, Moerland, P D, Alles, L K, van Kampen, A H C, van Gulik, T M, Heger, M, and van Golen, R F

Published
2019

4. Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma

Author

Reiniers, M J, de Haan, L, Weijer, R, Wiggers, J K, Jongejan, A, Moerland, P D, Alles, L K, van Kampen, A H C, van Gulik, T M, Heger, M, van Golen, R F, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, Pharmaceutics, Graduate School, Epidemiology and Data Science, APH - Methodology, AII - Inflammatory diseases, CCA - Cancer biology and immunology, Surgery, AGEM - Endocrinology, metabolism and nutrition, AGEM - Re-generation and cancer of the digestive system, Amsterdam Gastroenterology Endocrinology Metabolism, APH - Personalized Medicine, Sub Membrane Biochemistry & Biophysics, Afd Pharmaceutics, and Pharmaceutics

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Down-Regulation, Gene Expression, 030230 surgery, Preoperative care, Gastroenterology, behavioral disciplines and activities, Hepatitis, 03 medical and health sciences, 0302 clinical medicine, Cholestasis, Internal medicine, Preoperative Care, medicine, Humans, Patient group, Perihilar Cholangiocarcinoma, Gene, Biliary drainage, Microarray analysis techniques, business.industry, Middle Aged, medicine.disease, Microarray Analysis, Up-Regulation, Bile Duct Neoplasms, Drainage, 030211 gastroenterology & hepatology, Surgery, Female, business, Klatskin Tumor, Signal Transduction
Abstract

Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.

Published
2019

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