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Your search keyword '"van Geffen, Ankie J. P."' showing total 4 results
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4 results on '"van Geffen, Ankie J. P."'

1. MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support : Comparison of Continuous and Pulsatile Devices

Author

Lok, Sjoukje I., de Jonge, Nicolaas, van Kuik, Joyce, van Geffen, Ankie J. P., Huibers, Manon M. H., van der Weide, Petra, Siera, Erica, Winkens, Bjorn, Doevendans, Pieter A., de Weger, Roel A., Martins, Paula A. da Costa, Lok, Sjoukje I., de Jonge, Nicolaas, van Kuik, Joyce, van Geffen, Ankie J. P., Huibers, Manon M. H., van der Weide, Petra, Siera, Erica, Winkens, Bjorn, Doevendans, Pieter A., de Weger, Roel A., and Martins, Paula A. da Costa

Published
2015

2. MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices

Author

Cardiologie, Circulatory Health, Pathologie, Pathologie Laboratorium diagnostiek, Regenerative Medicine and Stem Cells, Cancer, Lok, Sjoukje I., de Jonge, Nicolaas, van Kuik, Joyce, van Geffen, Ankie J. P., Huibers, Manon M. H., van der Weide, Petra, Siera, Erica, Winkens, Bjorn, Doevendans, Pieter A., de Weger, Roel A., Martins, Paula A. da Costa, Cardiologie, Circulatory Health, Pathologie, Pathologie Laboratorium diagnostiek, Regenerative Medicine and Stem Cells, Cancer, Lok, Sjoukje I., de Jonge, Nicolaas, van Kuik, Joyce, van Geffen, Ankie J. P., Huibers, Manon M. H., van der Weide, Petra, Siera, Erica, Winkens, Bjorn, Doevendans, Pieter A., de Weger, Roel A., and Martins, Paula A. da Costa

Published
2015

3. MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices

Author

Lok, Sjoukje I., primary, de Jonge, Nicolaas, additional, van Kuik, Joyce, additional, van Geffen, Ankie J. P., additional, Huibers, Manon M. H., additional, van der Weide, Petra, additional, Siera, Erica, additional, Winkens, Bjorn, additional, Doevendans, Pieter A., additional, de Weger, Roel A., additional, and da Costa Martins, Paula A., additional

Published
2015
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4. Circulating growth differentiation factor-15 correlates with myocardial fibrosis in patients with non-ischaemic dilated cardiomyopathy and decreases rapidly after left ventricular assist device support.

Author

Lok SI, Winkens B, Goldschmeding R, van Geffen AJ, Nous FM, van Kuik J, van der Weide P, Klöpping C, Kirkels JH, Lahpor JR, Doevendans PA, de Jonge N, and de Weger RA

Subjects
Adult, Cardiomyopathy, Dilated blood, Cardiomyopathy, Dilated pathology, Cytokines blood, Female, Fibrosis pathology, Health Status Indicators, Humans, Male, Middle Aged, Prognosis, Program Evaluation, Risk Assessment, Statistics, Nonparametric, Time Factors, Ventricular Remodeling, Cardiomyopathy, Dilated therapy, Fibrosis blood, Growth Differentiation Factor 15 blood, Heart Ventricles pathology, Heart-Assist Devices, Ventricular Dysfunction, Left therapy
Abstract

Aims: Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine and is emerging as a biomarker of cardiac remodelling. Left ventricular assist devices (LVADs) provide unloading of the left ventricle, resulting in partial reverse remodelling. Our aim was to study GDF-15 in patients with a non-ischaemic dilated cardiomyopathy (DCM) during LVAD support., Methods and Results: We analysed circulating GDF-15 in 30 patients before and 1, 3, and 6 months after LVAD implantation and before heart transplantation or explantation. In addition, mRNA and protein expression of GDF-15 were evaluated in myocardial tissue obtained prior to and after LVAD support. Circulating GDF-15 was significantly higher before LVAD implantation as compared with healthy controls (P < 0.001). After 1 month of mechanical support, GDF-15 levels were significantly decreased compared with pre-implantation levels (P < 0.001) and remained stable thereafter. Circulating GDF-15 was significantly correlated with kidney function and the severity of myocardial fibrosis. Interestingly, GDF-15 mRNA and protein expression in the myocardium were hardly detectable., Conclusions: High circulating levels of GDF-15 in patients with end-stage non-ischaemic DCM correlate with myocardial fibrosis and kidney function and decline strongly after 1 month of mechanical unloading, remaining stable thereafter. However, cardiac mRNA and protein expression of GDF-15 are very low, suggesting that the heart is not an important source of GDF-15 production in these patients.

Published
2012
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