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2. Radiologic Assessment of Interbody Fusion: A Systematic Review on the Use, Reliability, and Accuracy of Current Fusion Criteria

Author

Duits, Anneli A.A. (author), Van Urk, Paul R. (author), Lehr, A. Mechteld (author), Nutzinger, Don (author), Reijnders, Maarten R.L. (author), Weinans, Harrie (author), Foppen, Wouter (author), Oner, F. Cuhmur (author), Van Gaalen, Steven M. (author), Kruyt, Moyo C. (author), Duits, Anneli A.A. (author), Van Urk, Paul R. (author), Lehr, A. Mechteld (author), Nutzinger, Don (author), Reijnders, Maarten R.L. (author), Weinans, Harrie (author), Foppen, Wouter (author), Oner, F. Cuhmur (author), Van Gaalen, Steven M. (author), and Kruyt, Moyo C. (author)

Abstract

Background: Lumbar interbody fusion (IF) is a common procedure to fuse the anterior spine. However, a lack of consensus on image-based fusion assessment limits the validity and comparison of IF studies. This systematic review aims to (1) report on IF assessment strategies and definitions and (2) summarize available literature on the diagnostic reliability and accuracy of these assessments. Methods: Two searches were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Search 1 identified studies on adult lumbar IF that provided a detailed description of image-based fusion assessment. Search 2 analyzed studies on the reliability of specific fusion criteria/classifications and the accuracy assessed with surgical exploration. Results: A total of 442 studies were included for search 1 and 8 studies for search 2. Fusion assessment throughout the literature was highly variable. Eighteen definitions and more than 250 unique fusion assessment methods were identified. The criteria that showed most consistent use were continuity of bony bridging, radiolucency around the cage, and angular motion <5°. However, reliability and accuracy studies were scarce. Conclusion: This review highlights the challenges in reaching consensus on IF assessment. The variability in IF assessment is very high, which limits the translatability of studies. Accuracy studies are needed to guide innovations of assessment. Future IF assessment strategies should focus on the standardization of computed tomography-based continuity of bony bridging. Knowledge from preclinical and imaging studies can add valuable information to this ongoing discussion., Biomaterials & Tissue Biomechanics

Published
2024
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3. Radiologic Assessment of Interbody Fusion: A Systematic Review on the Use, Reliability, and Accuracy of Current Fusion Criteria

Author

ORT Research, MS Orthopaedie Algemeen, Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Radiologie, Duits, Anneli A A, van Urk, Paul R, Lehr, A Mechteld, Nutzinger, Don, Reijnders, Maarten R L, Weinans, Harrie, Foppen, Wouter, Oner, F Cuhmur, van Gaalen, Steven M, Kruyt, Moyo C, ORT Research, MS Orthopaedie Algemeen, Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Radiologie, Duits, Anneli A A, van Urk, Paul R, Lehr, A Mechteld, Nutzinger, Don, Reijnders, Maarten R L, Weinans, Harrie, Foppen, Wouter, Oner, F Cuhmur, van Gaalen, Steven M, and Kruyt, Moyo C

Published
2024

5. Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial

Author

Nauth, Aaron, Creek, Aaron T., Zellar, Abby, Lawendy, Abdel-Rahman, Dowrick, Adam, Gupta, Ajay, Dadi, Akhil, van Kampen, Albert, Yee, Albert, de Vries, Alexander C., de Mol van Otterloo, Alexander, Garibaldi, Alisha, Liew, Allen, McIntyre, Allison W., Prasad, Amal Shankar, Romero, Amanda W., Rangan, Amar, Oatt, Amber, Sanghavi, Amir, Foley, Amy L., Karlsten, Anders, Dolenc, Andrea, Bucknill, Andrew, Chia, Andrew, Evans, Andrew, Gong, Andrew, Schmidt, Andrew H., Marcantonio, Andrew J., Jennings, Andrew, Ward, Angela, Khanna, Angshuman, Rai, Anil, Smits, Anke B., Horan, Annamarie D., Brekke, Anne Christine, Flynn, Annette, Duraikannan, Aravin, Stødle, Are, van Vugt, Arie B., Luther, Arlene, Zurcher, Arthur W., Jain, Arvind, Amundsen, Asgeir, Moaveni, Ash, Carr, Ashley, Sharma, Ateet, Hill, Austin D., Trommer, Axel, Rai, B. Sachidananda, Hileman, Barbara, Schreurs, Bart, Verhoeven, Bart, Barden, Benjamin B., Flatøy, Bernhard, Cleffken, Berry I., Bøe, Berthe, Perey, Bertrand, Hanusch, Birgit C., Weening, Brad, Fioole, Bram, Rijbroek, Bram, Crist, Brett D., Halliday, Brett, Peterson, Brett, Mullis, Brian, Richardson, C. Glen, Clark, Callum, Sagebien, Carlos A., van der Pol, Carmen C., Bowler, Carol, Humphrey, Catherine A., Coady, Catherine, Koppert, Cees L., Coles, Chad, Tannoury, Chadi, DePaolo, Charles J., Gayton, Chris, Herriott, Chris, Reeves, Christina, Tieszer, Christina, Dobb, Christine, Anderson, Christopher G., Sage, Claire, Cuento, Claudine, Jones, Clifford B., Bosman, Coks H.R., Linehan, Colleen, van der Hart, Cor P., Henderson, Corey, Lewis, Courtland G., Davis, Craig A., Donohue, Craig, Mauffrey, Cyril, Sundaresh, D.C., Farrell, Dana J., Whelan, Daniel B., Horwitz, Daniel, Stinner, Daniel, Viskontas, Darius, Roffey, Darren M., Alexander, David, Karges, David E., Hak, David, Johnston, David, Love, David, Wright, David M., Zamorano, David P., Goetz, David R., Sanders, David, Stephen, David, Yen, David, Bardana, Davide, Olakkengil, Davy J, Lawson, Deanna, Maddock, Deborah, Sietsema, Debra L., Pourmand, Deeba, Den Hartog, Dennis, Donegan, Derek, Heels-Ansdell, Diane, Nam, Diane, Inman, Dominic, Boyer, Dory, Li, Doug, Gibula, Douglas, Price, Dustin M., Watson, Dylan J., Hammerberg, E. Mark, Tan, Edward T.C.H., de Graaf, Eelco J.R., Vesterhus, Elise Berg, Roper, Elizabeth, Edwards, Elton, Schemitsch, Emil H., Hammacher, Eric R., Henderson, Eric R., Whatley, Erica, Torres, Erick T., Vermeulen, Erik G.J., Finn, Erin, Van Lieshout, Esther M.M., Wai, Eugene K., Bannister, Evan R., Kile, Evelyn, Theunissen, Evert B.M., Ritchie, Ewan D., Khan, Farah, Moola, Farhad, Howells, Fiona, de Nies, Frank, van der Heijden, Frank H.W.M., de Meulemeester, Frank R.A.J., Frihagen, Frede, Nilsen, Fredrik, Schmidt, G. Ben, Albers, G.H. Robert, Gudger, Garland K., Jr, Johnson, Garth, Gruen, Gary, Zohman, Gary, Sharma, Gaurav, Wood, Gavin, Tetteroo, Geert W.M., Hjorthaug, Geir, Jomaas, Geir, Donald, Geoff, Rieser, Geoffrey Ryan, Reardon, Gerald, Slobogean, Gerard P., Roukema, Gert R, Visser, Gijs A., Moatshe, Gilbert, Horner, Gillian, Rose, Glynis, Guyatt, Gordon, Chuter, Graham, Etherington, Greg, Rocca, Gregory J. Della, Ekås, Guri, Dobbin, Gwendolyn, Lemke, H. Michael, Curry, Hamish, Boxma, Han, Gissel, Hannah, Kreder, Hans, Kuiken, Hans, Brom, Hans L.F., Pape, Hans-Christoph, van der Vis, Harm M, Bedi, Harvinder, Vallier, Heather A., Brien, Heather, Silva, Heather, Newman, Heike, Viveiros, Helena, van der Hoeven, Henk, Ahn, Henry, Johal, Herman, Rijna, Herman, Stockmann, Heyn, Josaputra, Hong A., Carlisle, Hope, van der Brand, Igor, Dawson, Imro, Tarkin, Ivan, Wong, Ivan, Parr, J. Andrew, Trenholm, J. Andrew, Goslings, J. Carel, Amirault, J. David, Broderick, J. Scott, Snellen, Jaap P., Zijl, Jacco A.C., Ahn, Jaimo, Ficke, James, Irrgang, James, Powell, James, Ringler, James R., Shaer, James, Monica, James T., Biert, Jan, Bosma, Jan, Brattgjerd, Jan Egil, Frölke, Jan Paul M., Wille, Jan, Rajakumar, Janakiraman, Walker, Jane E., Baker, Janell K., Ertl, Janos P., de Vries, Jean Paul P.M., Gardeniers, Jean W.M., May, Jedediah, Yach, Jeff, Hidy, Jennifer T., Westberg, Jerald R., Hall, Jeremy A., van Mulken, Jeroen, McBeth, Jessica Cooper, Hoogendoorn, Jochem, Hoffman, Jodi M., Cherian, Joe Joseph, Tanksley, John A., Jr., Clarke-Jenssen, John, Adams, John D., Esterhai, John, Tilzey, John F., Murnaghan, John, Ketz, John P., Garfi, John S., Schwappach, John, Gorczyca, John T., Wyrick, John, Rydinge, Jonas, Foret, Jonathan L., Gross, Jonathan M., Keeve, Jonathan P., Meijer, Joost, Scheepers, Joris J.G., Baele, Joseph, O'Neil, Joseph, Cass, Joseph R., Hsu, Joseph R., Dumais, Jules, Lee, Julia, Switzer, Julie A., Agel, Julie, Richards, Justin E., Langan, Justin W., Turckan, Kahn, Pecorella, Kaili, Rai, Kamal, Aurang, Kamran, Shively, Karl, van Wessem, Karlijn, Moon, Karyn, Eke, Kate, Erwin, Katie, Milner, Katrine, Ponsen, Kees Jan, Mills, Kelli, Apostle, Kelly, Johnston, Kelly, Trask, Kelly, Strohecker, Kent, Stringfellow, Kenya, Kruse, Kevin K., III, Tetsworth, Kevin, Mitchell, Khalis, Browner, Kieran, Hemlock, Kim, Carcary, Kimberly, Jørgen Haug, Knut, Noble, Krista, Robbins, Kristin, Payton, Krystal, Jeray, Kyle J., Rubino, L. Joseph, Nastoff, Lauren A., Leffler, Lauren C., Stassen, Laurents P.S., O'Malley, Lawrence K., II, Specht, Lawrence M., Thabane, Lehana, Geeraedts, Leo M.G., Shell, Leslie E., Anderson, Linda K., Eickhoff, Linda S., Lyle, Lindsey, Pilling, Lindsey, Buckingham, Lisa, Cannada, Lisa K., Wild, Lisa M., Dulaney-Cripe, Liz, Poelhekke, Lodewijk M.S.J., Govaert, Lonneke, Ton, Lu, Kottam, Lucksy, Leenen, Luke P.H., Clipper, Lydia, Jackson, Lyle T., Hampton, Lynne, de Waal Malefijt, Maarten C., Simons, Maarten P., van der Elst, Maarten, Bronkhorst, Maarten W.G.A., Bhatia, Mahesh, Swiontkowski, Marc, Lobo, Margaret J., Swinton, Marilyn, Pirpiris, Marinis, Molund, Marius, Gichuru, Mark, Glazebrook, Mark, Harrison, Mark, Jenkins, Mark, MacLeod, Mark, de Vries, Mark R., Butler, Mark S., Nousiainen, Markku, van 't Riet, Martijne, Tynan, Martin C., Campo, Martin, Eversdijk, Martin G., Heetveld, Martin J., Richardson, Martin, Breslin, Mary, Fan, Mary, Edison, Matt, Napierala, Matthew, Knobe, Matthias, Russ, Matthias, Zomar, Mauri, de Brauw, Maurits, Esser, Max, Hurley, Meghan, Peters, Melissa E., Lorenzo, Melissa, Li, Mengnai, Archdeacon, Michael, Biddulph, Michael, Charlton, Michael, McDonald, Michael D., McKee, Michael D., Dunbar, Michael, Torchia, Michael E., Gross, Michael, Hewitt, Michael, Holt, Michael, Prayson, Michael J., Edwards, Michael J.R., Beckish, Michael L., Brennan, Michael L., Dohm, Michael P., Kain, Michael S.H., Vogt, Michelle, Yu, Michelle, Verhofstad, Michiel H.J., Segers, Michiel J.M., Siroen, Michiel P.C., Reed, Mike, Vicente, Milena R., Bruijninckx, Milko M.M., Trivedi, Mittal, Bhandari, Mohit, Moore, Molly M., Kunz, Monica, Smedsrud, Morten, Palla, Naveen, Jain, Neeraj, Out, Nico J.M., Simunovic, Nicole, Schep, Niels W.L., Müller, Oliver, Guicherit, Onno R., Van Waes, Oscar J.F., Wang, Otis, Doornebosch, Pascal G., Seuffert, Patricia, Hesketh, Patrick J., Weinrauch, Patrick, Duffy, Paul, Keller, Paul, Lafferty, Paul M., Pincus, Paul, Tornetta, Paul, III, Zalzal, Paul, McKay, Paula, Cole, Peter A., de Rooij, Peter D., Hull, Peter, Go, Peter M.N.Y.M., Patka, Peter, Siska, Peter, Weingarten, Peter, Kregor, Philip, Stahel, Philip, Stull, Philip, Wittich, Philippe, de Rijcke, Piet A.R., Oprel, Pim, Devereaux, PJ, Zhou, Qi, Lee Murphy, R., Jr., Alosky, Rachel, Clarkson, Rachel, Moon, Raely, Logishetty, Rajanikanth, Nanda, Rajesh, Sullivan, Raymond J., Snider, Rebecca G., Buckley, Richard E., Iorio, Richard, Farrugia, Richard J, Jenkinson, Richard, Laughlin, Richard, Groenendijk, Richard P.R., Gurich, Richard W., Jr, Worman, Ripley, Silvis, Rob, Haverlag, Robert, Teasdall, Robert J., Korley, Robert, McCormack, Robert, Probe, Robert, Cantu, Robert V., Huff, Roger B., Simmermacher, Rogier K.J., Peters, Rolf, Pfeifer, Roman, Liem, Ronald, Wessel, Ronald N., Verhagen, Ronald, Vuylsteke, Ronald, Leighton, Ross, McKercher, Ross, Poolman, Rudolf W., Miller, Russell, Bicknell, Ryan, Finnan, Ryan, Khan, Ryan M., Mehta, Samir, Vang, Sandy, Singh, Sanjay, Anand, Sanjeev, Anderson, Sarah A., Dawson, Sarah A., Marston, Scott B., Porter, Scott E., Watson, Scott T., Festen, Sebastiaan, Lieberman, Shane, Puloski, Shannon, Bielby, Shea A., Sprague, Sheila, Hess, Shelley, MacDonald, Shelley, Evans, Simone, Bzovsky, Sofia, Hasselund, Sondre, Lewis, Sophie, Ugland, Stein, Caminiti, Stephanie, Tanner, Stephanie L., Zielinski, Stephanie M., Shepard, Stephanie, Sems, Stephen A., Walter, Stephen D., Doig, Stephen, Finley, Stephen H., Kates, Stephen, Lindenbaum, Stephen, Kingwell, Stephen P., Csongvay, Steve, Papp, Steve, Buijk, Steven E., Rhemrev, Steven J., Hollenbeck, Steven M., van Gaalen, Steven M., Yang, Steven, Weinerman, Stuart, Subash, Lambert, Sue, Liew, Susan, Meylaerts, Sven A.G., Blokhuis, Taco J., de Vries Reilingh, Tammo S., Lona, Tarjei, Scott, Taryn, Swenson, Teresa K., Endres, Terrence J., Axelrod, Terry, van Egmond, Teun, Pace, Thomas B., Kibsgård, Thomas, Schaller, Thomas M., Ly, Thuan V., Miller, Timothy J., Weber, Timothy, Le, Toan, Oliver, Todd M., Karsten, Tom M., Borch, Tor, Hoseth, Tor Magne, Nicolaisen, Tor, Ianssen, Torben, Rutherford, Tori, Nanney, Tracy, Gervais, Trevor, Stone, Trevor, Schrickel, Tyson, Scrabeck, Tyson, Ganguly, Utsav, Naumetz, V., Frizzell, Valda, Wadey, Veronica, Jones, Vicki, Avram, Victoria, Mishra, Vimlesh, Yadav, Vineet, Arora, Vinod, Tyagi, Vivek, Borsella, Vivian, Willems, W. Jaap, Hoffman, W.H., Gofton, Wade T., Lackey, Wesley G., Ghent, Wesley, Obremskey, William, Oxner, William, Cross, William W., III, Murtha, Yvonne M., and Murdoch, Zoe

Published
2017
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9. Reliability, Validity, and Responsiveness of the Western Ontario and McMaster Universities Osteoarthritis Index for Elderly Patients with a Femoral Neck Fracture

Author

Burgers, Paul T.P.W., Poolman, Rudolf W, Van Bakel, Theodorus MJ, Tuinebreijer, Wim E, Zielinski, Stephanie M, Bhandari, Mohit, Patka, Peter, Van Lieshout, Esther MM, Bhandari, Mohit, Devereaux, P J, Guyatt, Gordon H, Einhorn, Thomas A, Thabane, Lehana, Schemitsch, Emil H, Koval, Kenneth J, Frihagen, Frede, Poolman, Rudolf W, Tetsworth, Kevin, Guerra-Farfan, Ernesto, Walter, Stephen D, Sprague, Sheila, Swinton, Marilyn, Scott, Taryn, McKay, Paula, Madden, Kim, Heels-Ansdell, Diane, Buckingham, Lisa, Duraikannan, Aravin, Silva, Heather, Heetveld, Martin J, Van Lieshout, Esther MM, Burgers, Paul T.P.W., Zura, Robert D, Avram, Victoria, Manjoo, Ajay, Williams, Dale, Antoniou, John, Ramsay, Tim, Bogoch, Earl R, Trenholm, Andrew, Lyman, Stephen, Mazumdar, Madhu, Bozic, Kevin J, Luborsky, Mark, Goodman, Stuart, Muray, Susan, Korley, Rob, Buckley, Richard, Duffy, Paul, Puloski, Shannon, Carcary, Kimberly, Lorenzo, Melissa, McKee, Michael D, Hall, Jeremy A, Nauth, Aaron, Whelan, Daniel, Daniels, Timothy R, Waddell, James P, Ahn, Henry, Vicente, Milena R, Hidy, Jennifer T, MacNevin, Melanie T, Kreder, Hans, Axelrod, Terry, Jenkinson, Richard, Nousiainen, Markku, Stephen, David, Wadey, Veronica, Kunz, Monica, Milner, Katrine, Cagaanan, Ria, MacNevin, Melanie, O’Brien, Peter J, Blachut, Piotr A, Broekhuyse, Henry M, Guy, Pierre, Lefaivre, Kelly A, Slobogean, Gerard P, Johal, Raman, Leung, Irene, Coles, Chad, Leighton, Ross, Richardson, C. Glen, Biddulph, Michael, Gross, Michael, Dunbar, Michael, Amirault, J. David, Alexander, David, Coady, Catherine, Glazebrook, Mark, Johnston, David, Oxner, William, Reardon, Gerald, Wong, Ivan, Trask, Kelly, MacDonald, Shelley, Furey, Andrew, Stone, Craig, Parsons, Minnie, Stone, Trevor, Zomar, Mauri, McCormack, Robert, Apostle, Kelly, Boyer, Dory, Moola, Farhad, Perey, Bertrand, Viskontas, Darius, Moon, Karyn, Moon, Raely, Laflamme, Yves, Benoit, Benoit, Ranger, Pierre, Malo, Michel, Fernandes, Julio, Tardif, Karine, Fournier, Julie, Vendittoli, Pascal André, Massé, Vincent, Roy, Alain G, Lavigne, Martin, Lusignan, Daniel, Davis, Craig, Stull, Philip, Weinerman, Stewart, Weingarten, Peter, Lindenbaum, Steven, Hewitt, Michael, Danielwicz, Rebecca, Baker, Janell, Mont, Michael, Delanois, Donald E, Kapadia, Bhaveen, Issa, Kimona, Mullen, Marylou, Sems, Andrew, Foreman, Barb, Parvizi, Javad, Morrison, Tiffany, Lewis, Courtland, Caminiti, Stephanie, Tornetta, Paul, III, Creevy, William R, Lespasio, Michelle J, Carlisle, Hope, Marcantonio, Andrew, Kain, Michael, Specht, Lawrence, Tilzey, John, Garfi, John, Mehta, Samir, Esterhai, John L, Jr., Ahn, Jaimo, Donegan, Derek, Horan, Annamarie, McGinnis, Kelly, Roberson, James, Bradbury, Thomas, Erens, Greg, Webb, Kyle, Mullis, Brian, Shively, Karl, Parr, Andrew, Ertl, Janos, Worman, Ripley, Webster, Mark, Cummings, Judd, Frizzell, Valda, Moore, Molly, Jones, Clifford B, Ringler, James R, Sietsema, Debra L, Walker, Jane E, Kanlic, Enes, Abdelgawad, Amr, Shunia, Juan, DePaolo, Charles, Sutherland, Susan, Alosky, Rachel, Zura, Robert, Manson, Maria, Strathy, Gregg, Peter, Kathleen, Johnson, Paul, Morton, Meaghan, Shaer, James, Schrickel, Tyson, Hileman, Barbara, Hanes, Marina, Chance, Elisha, Heinrich, E. Matthew, Dodgin, David, LaBadie, Michele, Zamorano, David, Tynan, Martin, Schwarzkopf, Ran, Scolaro, John A, Gupta, Ranjan, Bederman, Samuel, Bhatia, Nitin, Hoang, Bang, Kiester, Douglas, Jones, Neil, Rafijah, Gregory, Alavekios, Damon, Lee, Jason, Mehta, Akshay, Schroder, Steven, Chao, Tom, Colin, Vincent, Dang, Phuc (Phil), Heng, Stephen Keun, Lopez, Gregory, Galle, Samuel, Pahlavan, Sohrab, Phan, Duy L, Tapadia, Minal, Bui, Christopher, Jain, Nickul, Moore, Tyler, Moroski, Nathan, Pourmand, Deeba, Kubiak, Erik N, Gililland, Jeremy, Rothberg, David, Peters, Christopher, Pelt, Christopher, Stuart, Ami R, Corbey, Kirby, Shuler, Franklin D, Day, James, Garabekyan, Tigran, Cheung, Felix, Oliashirazi, Ali, Salava, Jonathon, Morgan, Linda, Wilson-Byrne, Timothy, Cordle, Mary Beth, Elmans, Leon H.G.J., van den Hout, Joost A.A.M., Joosten, Adrianus JP, van Beurden, Ad FA, Bolder, Stefan BT, Eygendaal, Denise, Moonen, Adrianus F.C.M., van Geenen, Rutger CI, Hoebink, Eric A, Wagenmakers, Robert, van Helden, Wouter, van Jonbergen, Hans-Peter W, Roerdink, Herbert, Reuver, Joost M, Barnaart, Alexander FW, Flikweert, Elvira R, Krips, Rover, Mullers, J. Bernard, Schüller, Hans, Falke, Mark LM, Kurek, Frans J, Slingerland, Adrianus CH, van Dijk, Jan P, van Helden, Wouter H, Bolhuis, Hugo W, Bullens, Pieter HJ, Hogervorst, Mike, de Kroon, Karin E, Jansen, Rob H, Steenstra, Ferry, Raven, Eric EJ, Fontijne, W. Peter J, Wiersma, Saskia C, Boetes, Bastiaan, ten Holder, Edgar JT, van der Heide, Huub JL, Nagels, Jochem, van der Linden-van der Zwaag, Enrike H.M.J., Keizer, Stefan B, Swen, Jan-Willem A, den Hollander, Peter HC, Thomassen, Bregje JW, Molekamp, Willem Jan Kleyn, de Meulemeester, Frank R.A.J., Kleipool, Arthur EB, Haverlag, Robert, Simons, Maarten P, Mutsaerts, Eduard L.A.R., Kooijman, Rob, Postema, Roelf R, Bleker, René J.T.M., Lampe, Harald IH, Schuman, Lein, Cheung, John, van Bommel, Frank, Winia, W. Paul, Haverkamp, Daniel, van der Vis, Harm, Nolte, Peter A, van den Bekerom, Michel PJ, de Jong, Tjitte, van Noort, Arthur, Vergroesen, Diederik A, Schutte, Bernard G, van der Vis, Harm M, Beimers, Lijkele, de Vries, Jasper, Zurcher, Arthur W, Albers, G.H. Rob, Rademakers, Maarten, Breugem, Stefan, van der Haven, Ibo, Jan Damen, Pieter, Bulstra, Gythe H, Campo, Martin M, Somford, Mathijs P, Haverkamp, Daniël, Liew, Susan, Bedi, Harvinder, Carr, Ashley, Chia, Andrew, Csongvay, Steve, Donohue, Craig, Doig, Stephen, Edwards, Elton, Esser, Max, Freeman, Richard, Gong, Andrew, Li, Doug, Miller, Russell, Ton, Lu, Wang, Otis, Young, Ian, Dowrick, Adam, Murdoch, Zoe, Sage, Claire, Page, Richard, Bainbridge, David, Angliss, Richard, Miller, Ben, Thomson, Andrew, Brown, Graeme, Williams, Simon, Eng, Kevin, Bowyer, David, Skelley, John, Goyal, Chatar, Beattie, Sally, Guerado, Enrique, Cruz, Encarnacion, Cano, Juan Ramon, Froufe, Miguel Angel, Serra, Lluis Marull, Al-dirra, Samer, Martinez, Cristina, Tarazona Santabalbina, Francisco José, Serra, Jordi Teixidor, Hernandez, Jordi Tomas, Garcia, Marc Aguilar, Garcia, Vicente Molero, Barrera, Sergi, Garrido, Miriam, Nordsletten, Lars, Clarke-Jenssen, John, Hjorthaug, Geir, Brekke, Anne Christine, Vesterhus, Elise Berg, Skaugrud, Ingunn, Tripathi, Pradeep, Katiyar, Sandesh, Shukla, Preksha, Swiontkowski, Marc, Guyatt, Gordon, Jeray, Kyle, Walter, Stephen, Viveiros, Helena, Truong, Victoria, Koo, Kaitlin, Zhou, Qi, Maddock, Deborah, Simunovic, Nicole, Agel, Julie, Zielinski, Stephanie M, Rangan, Amar, Hanusch, Birgit C, Kottam, Lucksy, Clarkson, Rachel, Della Rocca, Gregory J, Slobogean, Gerard, Katz, Jeffrey, Gillespie, Brenda, Greendale, Gail A, Hartman, Curtis, Rubin, Craig, Waddell, James, Lemke, H. Michael, Oatt, Amber, Buckley, Richard E, Korley, Robert, Johnston, Kelly, Powell, James, Sanders, David, Lawendy, Abdel, Tieszer, Christina, Murnaghan, John, Nam, Diane, Yee, Albert, Whelan, Daniel B, Wild, Lisa M, Khan, Ryan M, Coady, Cathy, Amirault, David, Richardson, Glen, Dobbin, Gwen, Bicknell, Ryan, Yach, Jeff, Bardana, Davide, Wood, Gavin, Harrison, Mark, Yen, David, Lambert, Sue, Howells, Fiona, Ward, Angela, Zalzal, Paul, Brien, Heather, Naumetz, V, Weening, Brad, Wai, Eugene K, Papp, Steve, Gofton, Wade T, Kingwell, Stephen P, Johnson, Garth, O’Neil, Joseph, Roffey, Darren M, Borsella, Vivian, Oliver, Todd M, Jones, Vicki, Endres, Terrence J, Agnew, Samuel G, Jeray, Kyle J, Broderick, J. Scott, Goetz, David R, Pace, Thomas B, Schaller, Thomas M, Porter, Scott E, Tanner, Stephanie L, Snider, Rebecca G, Nastoff, Lauren A, Bielby, Shea A, Switzer, Julie A, Cole, Peter A, Anderson, Sarah A, Lafferty, Paul M, Li, Mengnai, Ly, Thuan V, Marston, Scott B, Foley, Amy L, Vang, Sandy, Wright, David M, Marcantonio, Andrew J, Kain, Michael SH, Iorio, Richard, Specht, Lawrence M, Tilzey, John F, Lobo, Margaret J, Garfi, John S, Vallier, Heather A, Dolenc, Andrea, Robinson, Chalitha, Prayson, Michael J, Laughlin, Richard, Rubino, L. Joseph, May, Jedediah, Rieser, Geoffrey Ryan, Dulaney-Cripe, Liz, Gayton, Chris, Gorczyca, John T, Gross, Jonathan M, Humphrey, Catherine A, Kates, Stephen, Noble, Krista, McIntyre, Allison W, Pecorella, Kaili, Davis, Craig A, Lindenbaum, Stephen, Schwappach, John, Baker, Janell K, Rutherford, Tori, Newman, Heike, Lieberman, Shane, Finn, Erin, Robbins, Kristin, Hurley, Meghan, Lyle, Lindsey, Mitchell, Khalis, Browner, Kieran, Whatley, Erica, Payton, Krystal, Reeves, Christina, Cannada, Lisa K, Karges, David, Hill, Leslie, Esterhai, John, Horan, Annamarie D, Kaminski, Christine A, Kowalski, Brynn N, Keeve, Jonathan P, Anderson, Christopher G, McDonald, Michael D, Hoffman, Jodi M, Tarkin, Ivan, Siska, Peter, Gruen, Gary, Evans, Andrew, Farrell, Dana J, Irrgang, James, Luther, Arlene, Cross, William W, III, Cass, Joseph R, Sems, Stephen A, Torchia, Michael E, Scrabeck, Tyson, Jenkins, Mark, Dumais, Jules, Romero, Amanda W, Sagebien, Carlos A, Butler, Mark S, Monica, James T, Seuffert, Patricia, Hsu, Joseph R, Ficke, James, Charlton, Michael, Napierala, Matthew, Fan, Mary, Tannoury, Chadi, Archdeacon, Michael, Finnan, Ryan, Le, Toan, Wyrick, John, Hess, Shelley, Brennan, Michael L, Probe, Robert, Kile, Evelyn, Mills, Kelli, Clipper, Lydia, Yu, Michelle, Erwin, Katie, Horwitz, Daniel, Strohecker, Kent, Swenson, Teresa K, Schmidt, Andrew H, Westberg, Jerald R, Aurang, Kamran, Zohman, Gary, Peterson, Brett, Huff, Roger B, Baele, Joseph, Weber, Timothy, Edison, Matt, McBeth, Jessica, Ertl, Janos P, Parr, J. Andrew, Moore, Molly M, Tobias, Erin, Thomas, Emily, DePaolo, Charles J, Shell, Leslie E, Hampton, Lynne, Shepard, Stephanie, Nanney, Tracy, Cuento, Claudine, Cantu, Robert V, Henderson, Eric R, Eickhoff, Linda S, Hammerberg, E. Mark, Stahel, Philip, Hak, David, Mauffrey, Cyril, Gibula, Douglas, Gissel, Hannah, Henderson, Corey, Zamorano, David P, Tynan, Martin C, Lawson, Deanna, Crist, Brett D, Murtha, Yvonne M, Anderson, Linda K, Linehan, Colleen, Pilling, Lindsey, Lewis, Courtland G, Sullivan, Raymond J, Roper, Elizabeth, Obremskey, William, Kregor, Philip, Richards, Justin E, Stringfellow, Kenya, Dohm, Michael P, Zellar, Abby, Segers, Michiel JM, Zijl, Jacco AC, Verhoeven, Bart, Smits, Anke B, de Vries, Jean Paul PM, Fioole, Bram, van der Hoeven, Henk, Theunissen, Evert BM, de Vries Reilingh, Tammo S, Govaert, Lonneke, Wittich, Philippe, de Brauw, Maurits, Wille, Jan, Go, Peter M.N.Y.M., Ritchie, Ewan D, Wessel, Ronald N, Hammacher, Eric R, Visser, Gijs A, Stockmann, Heyn, Silvis, Rob, Snellen, Jaap P, Rijbroek, Bram, Scheepers, Joris JG, Vermeulen, Erik GJ, Siroen, Michiel PC, Vuylsteke, Ronald, Brom, Hans LF, Rijna, Herman, de Rijcke, Piet AR, Koppert, Cees L, Buijk, Steven E, Groenendijk, Richard PR, Dawson, Imro, Tetteroo, Geert WM, Bruijninckx, Milko MM, Doornebosch, Pascal G, de Graaf, Eelco JR, van der Elst, Maarten, van der Pol, Carmen C, van’t Riet, Martijne, Karsten, Tom M, de Vries, Mark R, Stassen, Laurents PS, Schep, Niels WL, Ben Schmidt, G, Hoffman, W H, van der Heijden, Frank H.W.M., Willems, W. Jaap, van der Hart, Cor P, Turckan, Kahn, Festen, Sebastiaan, de Nies, Frank, Out, Nico JM, Bosma, Jan, van Kampen, Albert, Biert, Jan, van Vugt, Arie B, Edwards, Michael JR, Blokhuis, Taco J, Frölke, Jan Paul M, Geeraedts, Leo MG, Gardeniers, Jean WM, Tan, Edward T.C.H., Poelhekke, Lodewijk M.S.J., de Waal Malefijt, Maarten C, Schreurs, Bart, Roukema, Gert R, Josaputra, Hong A, Keller, Paul, de Rooij, Peter D, Kuiken, Hans, Boxma, Han, Cleffken, Berry I, Liem, Ronald, Rhemrev, Steven J, Bosman, Coks HR, de Mol van Otterloo, Alexander, Hoogendoorn, Jochem, de Vries, Alexander C, Meylaerts, Sven AG, Verhofstad, Michiel HJ, Meijer, Joost, van Egmond, Teun, van der Brand, Igor, Patka, Peter, Eversdijk, Martin G, Peters, Rolf, Den Hartog, Dennis, Van Waes, Oscar JF, Oprel, Pim, Campo, Martin, Verhagen, Ronald, Albers, G.H. Robert, Simmermacher, Rogier KJ, van Mulken, Jeroen, van Wessem, Karlijn, van Gaalen, Steven M, Leenen, Luke PH, Bronkhorst, Maarten W.G.A., Guicherit, Onno R, Goslings, J. Carel, Ponsen, Kees Jan, Bhatia, Mahesh, Arora, Vinod, Tyagi, Vivek, Gupta, Ajay, Jain, Neeraj, Khan, Farah, Sharma, Ateet, Sanghavi, Amir, Trivedi, Mittal, Rai, Anil, Subash, Rai, Kamal, Yadav, Vineet, Singh, Sanjay, Prasad, Amal Shankar, Mishra, Vimlesh, Sundaresh, D C, Khanna, Angshuman, Cherian, Joe Joseph, Olakkengil, Davy J, Sharma, Gaurav, Dadi, Akhil, Palla, Naveen, Ganguly, Utsav, Rai, B. Sachidananda, Rajakumar, Janakiraman, Hull, Peter, Lewis, Sophie, Evans, Simone, Nanda, Rajesh, Logishetty, Rajanikanth, Anand, Sanjeev, Bowler, Carol, Jennings, Andrew, Chuter, Graham, Rose, Glynis, Horner, Gillian, Clark, Callum, Eke, Kate, Reed, Mike, Herriott, Chris, Dobb, Christine, Curry, Hamish, Etherington, Greg, Jain, Arvind, Moaveni, Ash, Russ, Matthias, Donald, Geoff, Weinrauch, Patrick, Pincus, Paul, Yang, Steven, Halliday, Brett, Gervais, Trevor, Holt, Michael, Flynn, Annette, Pirpiris, Marinis, Love, David, Bucknill, Andrew, Farrugia, Richard J, Ianssen, Torben, Amundsen, Asgeir, Brattgjerd, Jan Egil, Borch, Tor, Bøe, Berthe, Flatøy, Bernhard, Hasselund, Sondre, Haug, Knut Jørgen, Hemlock, Kim, Hoseth, Tor Magne, Jomaas, Geir, Kibsgård, Thomas, Lona, Tarjei, Moatshe, Gilbert, Müller, Oliver, Molund, Marius, Nicolaisen, Tor, Nilsen, Fredrik, Rydinge, Jonas, Smedsrud, Morten, Stødle, Are, Trommer, Axel, Ugland, Stein, Karlsten, Anders, Ekås, Guri, Pape, Hans-Christoph, Knobe, Matthias, and Pfeifer, Roman

Published
2015
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11. Letter to the editor regarding 'Two-year results of a double-blind multicenter randomized controlled non-inferiority trial of polyetheretherketone (PEEK) versus silicon nitride spinal fusion cages in patients with symptomatic degenerative lumbar disc disorders'

Author

Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, Roel F M R, Öner, F Cumhur, Arts, Mark P, Mitroiu, Marian, Roes, Kit C B, de Gast, Arthur, van Gaalen, Steven M, Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, MS Orthopaedie Algemeen, CTM & Statistical consultation, Kersten, Roel F M R, Öner, F Cumhur, Arts, Mark P, Mitroiu, Marian, Roes, Kit C B, de Gast, Arthur, and van Gaalen, Steven M

Published
2021

12. Letter to the editor regarding “Two-year results of a double-blind multicenter randomized controlled non-inferiority trial of polyetheretherketone (PEEK) versus silicon nitride spinal fusion cages in patients with symptomatic degenerative lumbar disc disorders”

Author

Kersten, Roel F. M. R., primary, Öner, F. Cumhur, additional, Arts, Mark P., additional, Mitroiu, Marian, additional, Roes, Kit C. B., additional, de Gast, Arthur, additional, and van Gaalen, Steven M., additional

Published
2021
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13. Injuries related to bicycle accidents: an epidemiological study in The Netherlands

Author

Zorgeenheid Vaatchirurgie Medisch, Orthopaedie Opleiding, Verpleegafd Vaatchirurgie D4 Oost, Zorgeenheid Traumatologie, Infection & Immunity, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, de Guerre, Livia E.V.M., Sadiqi, Said, Leenen, Loek P.H., Oner, Cumhur F., van Gaalen, Steven M., Zorgeenheid Vaatchirurgie Medisch, Orthopaedie Opleiding, Verpleegafd Vaatchirurgie D4 Oost, Zorgeenheid Traumatologie, Infection & Immunity, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, de Guerre, Livia E.V.M., Sadiqi, Said, Leenen, Loek P.H., Oner, Cumhur F., and van Gaalen, Steven M.

Published
2020

14. Comparison of polyetheretherketone versus silicon nitride intervertebral spinal spacers in a caprine model

Author

Kersten, Roel F.M.R., Wu, Gang, Pouran, Behdad, van der Veen, Albert J., Weinans, Harrie H., de Gast, Arthur, Öner, F. Cumhur, and van Gaalen, Steven M.

Subjects
caprine animal model, Biomaterials, silicon nitride, interbody cage, polyetheretherketone, Biomedical Engineering, Journal Article, osseointegration
Abstract

Polyetheretherketone (PEEK) is commonly used as a spinal spacer for intervertebral fusion surgery. Unfortunately, PEEK is bioinert and does not effectively osseointegrate into living bone. In contrast, comparable spacers made of silicon nitride (Si3N4) possess a surface nanostructure and chemistry that encourage appositional bone healing. This observational study was designed to compare the outcomes of these two biomaterials when implanted as spacers in an adult caprine model. Lumbar interbody fusion surgeries were performed at two adjacent levels in eight adult goats using implants of PEEK and Si3N4. At six-months after surgery, the operative and adjacent spinal segments were extracted and measured for bone fusion, bone volume, bone-implant contact (BIC) and soft-tissue implant contact (SIC) ratios, and biodynamic stability. The null hypothesis was that no differences in these parameters would be apparent between the two groups. Fusion was observed in seven of eight implants in each group with greater bone formation in the Si3N4 group (52.6%) versus PEEK (27.9%; p = 0.2). There were no significant differences in BIC ratios between PEEK and Si3N4, and the biodynamic stability of the two groups was also comparable. The results suggest that Si3N4 spacers are not inferior to PEEK and they may be more effective in promoting arthrodesis.

Published
2019

15. Non-equivalent results from different anteversion measurements methods for the evaluation of the acetabular cup orientation in total hip arthroplasty

Author

Snijders, Thom E. (author), Schlösser, Tom P.C. (author), van Gaalen, Steven M. (author), Castelein, Rene M. (author), Weinans, H.H. (author), de Gast, Arthur (author), Snijders, Thom E. (author), Schlösser, Tom P.C. (author), van Gaalen, Steven M. (author), Castelein, Rene M. (author), Weinans, H.H. (author), and de Gast, Arthur (author)

Abstract

Objective: To determine the comparability among 10 radiographic anteversion methods for acetabular cup orientation in total hip arthroplasty (THA) found in the literature and the “gold” standard of assessing the anteversion with CT. Methods: This is a retrospective study that blindly compares 10 different conventional radiographic anteversion measurements with the “gold” standard, the measurement of anteversion on the transverse plane of the 3-D images made with CT. The patient archiving and communications system (PACS) was systematically searched for subjects that had undergone a CT angiogram of the abdomen and lower extremities, including the pelvis, had at least one THA in situ and had undergone anterior-posterior (AP) and cross-lateral pelvic radiography between January 2013 and August 2016 in the Diakonessenhuis Hospital Utrecht/Zeist, a non-academic institution. CT scans of patients (n = 16) were systematically collected. Three observers independently measured cup anteversion from radiographs, using a total of 10 different methods, and measured the “gold” standard on CT images. The outcomes of the 10 radiographic anteversion were compared in terms of linear correlation with the “gold” standard on CT images. Results: The correlations of the radiographic measured anteversions with the “gold” standard measured on CT images were 0.528 for the method of Liaw, 0.556 for Wan, 0.562 for the cross-lateral method, 0.586 for Hassan, 0.594 for Dorr, 0.602 for Lewinnek, 0.624 for Widmer, 0.671 for the lateral CT, 0.747 for Ackland, and 0.771 for the method of Riten Pradham. Conclusion: Anteversion measurement methods represent different projectional angles of the acetabular cup in different planes around different axes. Therefore, they differ from the “gold” standard and are not interchangeable, as is shown by this study. We consider the anatomical anteversion in the transverse plane rotating around the longitudinal axis as the “gold” standard and recommend avoiding usi, Biomaterials & Tissue Biomechanics

Published
2019
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16. Comparison of polyetheretherketone versus silicon nitride intervertebral spinal spacers in a caprine model

Author

Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, Kersten, Roel F.M.R., Wu, Gang, Pouran, Behdad, van der Veen, Albert J., Weinans, Harrie H., de Gast, Arthur, Öner, F. Cumhur, van Gaalen, Steven M., Orthopaedie Onderzoek, Regenerative Medicine and Stem Cells, MS Orthopaedie Spine, Kersten, Roel F.M.R., Wu, Gang, Pouran, Behdad, van der Veen, Albert J., Weinans, Harrie H., de Gast, Arthur, Öner, F. Cumhur, and van Gaalen, Steven M.

Published
2019

17. Temporary Segmental Distraction in a Dog with Degenerative Lumbosacral Stenosis

Author

Willems, Nicole, Kersten, Roel F.M.R., Van Gaalen, Steven M., Öner, F. Cumhur, Strijkers, Gustav J., Veraa, Stefanie, Beukers, Martijn, Tryfonidou, Marianna A., Meij, Björn P., Opleiding chirurgie, Diagnostische beeldvorming, Orthopedie en neurochirurgie, LS Algemene chirurgie, dCSCA RMSC-1, dCSCA AVR, Opleiding chirurgie, Diagnostische beeldvorming, Orthopedie en neurochirurgie, LS Algemene chirurgie, dCSCA RMSC-1, dCSCA AVR, ACS - Atherosclerosis & ischemic syndromes, AMS - Sports & Work, Biomedical Engineering and Physics, and ACS - Heart failure & arrhythmias

Subjects
medicine.medical_specialty, 040301 veterinary sciences, medicine.medical_treatment, education, Lumbar vertebrae, Constriction, Pathologic, Intervertebral Disc Degeneration, behavioral disciplines and activities, 0403 veterinary science, 03 medical and health sciences, 0302 clinical medicine, Dogs, Spinal Stenosis, Pedicle Screws, Distraction, medicine, Back pain, Animals, Dog Diseases, Fixation (histology), Lumbar Vertebrae, General Veterinary, business.industry, Lumbosacral Region, Intervertebral disc, 04 agricultural and veterinary sciences, medicine.disease, lower back pain, humanities, Surgery, Stenosis, medicine.anatomical_structure, Spinal Fusion, Treatment Outcome, Spinal fusion, dog, Animal Science and Zoology, intervertebral disc, medicine.symptom, degenerative lumbosacral stenosis, business, 030217 neurology & neurosurgery, Lumbosacral joint, psychological phenomena and processes, distraction
Abstract

Objectives Degenerative lumbosacral stenosis (DLSS) is characterized by intervertebral disc degeneration and causes lower back pain in dogs. Temporary distraction in rabbit models with induced intervertebral disc degeneration showed signs of intervertebral disc repair. In the present study, we assessed safety and efficacy of temporary segmental distraction in a dog with clinical signs of DLSS. Methods Distraction of the lumbosacral junction by pedicle screw–rod fixation was applied in a 5-year-old Greyhound with DLSS and evaluated by radiography, magnetic resonance imaging, and force plate analysis before and after distraction. Results Safe distraction of the lumbosacral junction was demonstrated, with improvement of clinical signs after removal of the distraction device. Signal intensity of the intervertebral disc showed no changes over time. T2 value was highest directly after removal of the distraction device but decreased by 10% of the preoperative value at 9 months of follow-up. Disc height decreased (8%) immediately after removal of the distraction device, but recovered to the initial value. A decrease in the pelvic/thoracic propulsive force during pedicle screw–rod fixation and distraction was demonstrated, which slowly increased by 4% compared with the initial value. Clinical significance Temporary pedicle screw–rod fixation in combination with distraction in a dog with DLSS was safe, improved clinical signs and retained disc height at 9 months of follow-up.

Published
2018

19. Temporary Segmental Distraction in a Dog with Degenerative Lumbosacral Stenosis

Author

Opleiding chirurgie, Diagnostische beeldvorming, Orthopedie en neurochirurgie, LS Algemene chirurgie, dCSCA RMSC-1, dCSCA AVR, Willems, Nicole, Kersten, Roel F.M.R., Van Gaalen, Steven M., Öner, F. Cumhur, Strijkers, Gustav J., Veraa, Stefanie, Beukers, Martijn, Tryfonidou, Marianna A., Meij, Björn P., Opleiding chirurgie, Diagnostische beeldvorming, Orthopedie en neurochirurgie, LS Algemene chirurgie, dCSCA RMSC-1, dCSCA AVR, Willems, Nicole, Kersten, Roel F.M.R., Van Gaalen, Steven M., Öner, F. Cumhur, Strijkers, Gustav J., Veraa, Stefanie, Beukers, Martijn, Tryfonidou, Marianna A., and Meij, Björn P.

Published
2018

20. Poor intermediate-term survival of the uncemented Optan anatomically adapted femoral component

Author

Heijnens, Luc J M, Halma, Jelle J, van Gaalen, Steven M, and de Gast, Arthur

Subjects
musculoskeletal diseases, Adult, Aged, 80 and over, Male, Reoperation, Femur Neck, Arthroplasty, Replacement, Hip, Bone Cements, Kaplan-Meier Estimate, Middle Aged, Prosthesis Design, Prosthesis Failure, Radiography, Hip and Pelvis, Treatment Outcome, Surveys and Questionnaires, Humans, Female, Hip Prosthesis, Range of Motion, Articular, Aged, Follow-Up Studies, Retrospective Studies
Abstract

Purpose We evaluated the 5-year survival of the uncemented Optan anatomically adapted femoral stem, with revision for aseptic loosening as the endpoint. Methods Between January 2004 and March 2007, 432 total hip arthroplasties (THAs) were performed in 432 patients. After follow-up for a mean time of 5 years, the patients were evaluated using the WOMAC questionnaire and plain radiography. Patients who were unable to attend the follow-up visit were contacted by telephone to determine whether they had had any revision surgery of their THA Results Within 5 years, 39 patients (9%) had died of unrelated causes and 63 patients (15%) had been lost to follow-up. Of the remaining cohort, 224 patients (68%) had full follow-up while 88 patients (27%) were evaluated with WOMAC only and 18 patients (5%) were evaluated with radiography only. The mean WOMAC score of all evaluated patients was 21 (10–100). At 5-year follow-up, there were 26 stem revisions reported (6%), 14 hips (3%) showed aseptic loosening, and 12 hips (3%) had had a periprosthetic femoral fracture. The 5-year survival to revision for any reason was 94%. Worst-case analysis yielded a 5-year survival of 79%. Interpretation The 5-year survival for aseptic loosening of the Optan anatomically adapted femoral component was disappointing. Radiographic evaluation showed evidence of proximal radiolucencies and distal cortical bone hypertrophy, which we attribute to insufficient proximal bone in-growth and increased load transfer at the tip of the stem. We do not recommend the use of the Optan femoral stem.

Published
2014

24. Lack of consensus on optimal acetabular cup orientation because of variation in assessment methods in total hip arthroplasty: a systematic review.

Author

Snijders, Thom E., Willemsen, Koen, van Gaalen, Steven M., Castelein, Rene M., Weinans, Harrie, and de Gast, Arthur

Subjects
ACETABULUM surgery, INFORMATION storage & retrieval systems, MEDICAL databases, MEDICAL information storage & retrieval systems, MEDLINE, ONLINE information services, PATIENT positioning, POSTOPERATIVE care, PREOPERATIVE care, TOTAL hip replacement, SYSTEMATIC reviews, TREATMENT effectiveness
Abstract

Introduction: Dislocation is 1 of the main reasons for revision of total hip arthroplasty but dislocation rates have not changed in the past decades, compromising patients' well-being. Acetabular cup orientation plays a key role in implant stability and has been widely studied. This article investigates whether there is a consensus on optimal cup orientation, which is necessary when using a navigation system. Methods: A systematic search of the literature in the PubMed, Embase and Cochrane databases was performed (March 2017) to identify articles that investigated the direct relationship between cup orientation and dislocation, including a thorough evaluation of postoperative cup orientation assessment methods. Results: 28 relevant articles evaluating a direct relation between dislocation and cup orientation could not come to a consensus. The key reason is a lack of uniformity in the assessment of cup orientation. Cup orientation is assessed with different imaging modalities, different methodologies, different definitions for inclination and anteversion, several reference planes and distinct patient positions. Conclusions: All available studies lack uniformity in cup orientation assessment; therefore it is impossible to reach consensus on optimal cup orientation. Using navigation systems for placement of the cup is inevitably flawed when using different definitions in the preoperative planning, peroperative placement and postoperative evaluation. Further methodological development is required to assess cup orientation. Consequently, the postoperative assessment should be uniform, thus differentiating between anterior and posterior dislocation, use the same definitions for inclination and anteversion with the same reference plane and with the patient in the same position. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures

Author

McCormack, Robert, Apostle, Kelly, Moon, Raely, Bielby, Shea A., Switzer, Julie A., Cole, Peter A., Anderson, Sarah A., Lafferty, Paul M., Li, Mengnai, Ly, Thuan V., Marston, Scott B., Foley, Amy L., Vang, Sandy, Oatt, Amber, Wright, David M., Marcantonio, Andrew J., Kain, Michael S. H., Iorio, Richard, Specht, Lawrence M., Tilzey, John F., Lobo, Margaret J., Garfi, John S., Vallier, Heather A., Dolenc, Andrea, Buckley, Richard E., Robinson, Chalitha, Prayson, Michael J., Laughlin, Richard, Rubino, L. Joseph, May, Jedediah, Rieser, Geoffrey Ryan, Dulaney-Cripe, Liz, Gayton, Chris, Shaer, James, Schrickel, Tyson, Duffy, Paul, Hileman, Barbara, Gorczyca, John T., Gross, Jonathan M., Humphrey, Catherine A., Kates, Stephen, Noble, Krista, McIntyre, Allison W., Pecorella, Kaili, Davis, Craig A., Weinerman, Stewart, Korley, Robert, Weingarten, Peter, Stull, Philip, Lindenbaum, Stephen, Hewitt, Michael, Schwappach, John, Baker, Janell K., Rutherford, Tori, Newman, Heike, Lieberman, Shane, Finn, Erin, Puloski, Shannon, Robbins, Kristin, Hurley, Meghan, Lyle, Lindsey, Mitchell, Khalis, Browner, Kieran, Whatley, Erica, Payton, Krystal, Reeves, Christina, Cannada, Lisa K., Karges, David, Johnston, Kelly, Hill, Leslie, Mehta, Samir, Esterhai, John, Ahn, Jaimo, Horan, Annamarie D., McGinnis, Kelly, Kaminski, Christine A., Kowalski, Brynn N., Keeve, Jonathan P., Anderson, Christopher G., Powell, James, McDonald, Michael D., Hoffman, Jodi M., Tarkin, Ivan, Siska, Peter, Gruen, Gary, Evans, Andrew, Farrell, Dana J., Irrgang, James, Luther, Arlene, Cross III., William W., Carcary, Kimberly, Cass, Joseph R., Sems, Stephen A., Torchia, Michael E., Scrabeck, Tyson, Jenkins, Mark, Dumais, Jules, Romero, Amanda W., Sagebien, Carlos A., Butler, Mark S., Monica, James T., Sanders, David, Seuffert, Patricia, Hsu, Joseph R., Ficke, James, Charlton, Michael, Napierala, Matthew, Fan, Mary, Tornetta III., Paul, Tannoury, Chadi, Carlisle, Hope, Silva, Heather, Boyer, Dory, Lawendy, Abdel, Archdeacon, Michael, Finnan, Ryan, Le, Toan, Wyrick, John, Hess, Shelley, Brennan, Michael L., Probe, Robert, Kile, Evelyn, Mills, Kelli, Clipper, Lydia, Tieszer, Christina, Yu, Michelle, Erwin, Katie, Horwitz, Daniel, Strohecker, Kent, Swenson, Teresa K., Aurang, Kamran, Zohman, Gary, Peterson, Brett, Huff, Roger B., Baele, Joseph, Stephen, David, Weber, Timothy, Edison, Matt, McBeth, Jessica, Shively, Karl, Ertl, Janos P., Mullis, Brian, Parr, J. Andrew, Worman, Ripley, Frizzell, Valda, Moore, Molly M., Kreder, Hans, Tobias, Erin, Thomas, Emily, DePaolo, Charles J., Alosky, Rachel, Shell, Leslie E., Hampton, Lynne, Shepard, Stephanie, Nanney, Tracy, Cuento, Claudine, Cantu, Robert V., Jenkinson, Richard, Henderson, Eric R., Eickhoff, Linda S., Hammerberg, E. Mark, Stahel, Philip, Hak, David, Mauffrey, Cyril, Gibula, Douglas, Gissel, Hannah, Henderson, Corey, Zamorano, David P., Nousiainen, Markku, Tynan, Martin C., Pourmand, Deeba, Lawson, Deanna, Della Rocca, Gregory J., Crist, Brett D., Murtha, Yvonne M., Anderson, Linda K., Linehan, Colleen, Pilling, Lindsey, Lewis, Courtland G., Axelrod, Terry, Caminiti, Stephanie, Sullivan, Raymond J., Roper, Elizabeth, Obremskey, William, Kregor, Philip, Richards, Justin E., Stringfellow, Kenya, Dohm, Michael P., Zellar, Abby, Segers, Michiel J. M., Murnaghan, John, Zijl, Jacco A. C., Verhoeven, Bart, Smits, Anke B., de Vries, Jean Paul P. M., Fioole, Bram, van der Hoeven, Henk, Theunissen, Evert B. M., de Vries Reilingh, Tammo S., Govaert, Lonneke, Wittich, Philippe, Nam, Diane, de Brauw, Maurits, Wille, Jan, Go, Peter M. N. Y. M., Ritchie, Ewan D., Wessel, Ronald N., Hammacher, Eric R., Heetveld, Martin J., Visser, Gijs A., Stockmann, Heyn, Silvis, Rob, Wadey, Veronica, Snellen, Jaap P., Rijbroek, Bram, Scheepers, Joris J. G., Vermeulen, Erik G. J., Siroen, Michiel P. C., Vuylsteke, Ronald, Brom, Hans L. F., Rijna, Herman, de Rijcke, Piet A. R., Koppert, Cees L., Moola, Farhad, Yee, Albert, Buijk, Steven E., Groenendijk, Richard P. R., Dawson, Imro, Tetteroo, Geert W. M., Bruijninckx, Milko M. M., Doornebosch, Pascal G., de Graaf, Eelco J. R., van der Elst, Maarten, van der Pol, Carmen C., van 't Riet, Martijne, Milner, Katrine, Karsten, Tom M., de Vries, Mark R., Stassen, Laurents P. S., Schep, Niels W. L., Schmidt, G. Ben, Hoffman, W. H., Poolman, Rudolf W., Simons, Maarten P., van der Heijden, Frank H. W. M., Willems, W. Jaap, Kunz, Monica, de Meulemeester, Frank R. A. J., van der Hart, Cor P., Turckan, Kahn, Festen, Sebastiaan, de Nies, Frank, Haverlag, Robert, Out, Nico J. M., Bosma, Jan, van Kampen, Albert, Biert, Jan, Schemitsch, Emil H., van Vugt, Arie B., Edwards, Michael J. R., Blokhuis, Taco J., Frolke, Jan Paul M., Geeraedts, Leo M. G., Gardeniers, Jean W. M., Tan, Edward T. C. H., Poelhekke, Lodewijk M. S. J., de Waal Malefijt, Maarten C., Schreurs, Bart, Ahn, Henry, Roukema, Gert R., Josaputra, Hong A., Keller, Paul, de Rooij, Peter D., Kuiken, Hans, Boxma, Han, Cleffken, Berry I., Liem, Ronald, Rhemrev, Steven J., Bosman, Coks H. R., Hall, Jeremy A., de Mol van Otterloo, Alexander, Hoogendoorn, Jochem, de Vries, Alexander C., Meylaerts, Sven A. G., Verhofstad, Michiel H. J., Meijer, Joost, van Egmond, Teun, van der Brand, Igor, Patka, Peter, McKee, Michael D., Eversdijk, Martin G., Peters, Rolf, Den Hartog, Dennis, Van Waes, Oscar J. F., Oprel, Pim, van der Vis, Harm M., Campo, Martin, Verhagen, Ronald, Albers, G. H. Robert, Zurcher, Arthur W., Whelan, Daniel B., Simmermacher, Rogier K. J., van Mulken, Jeroen, van Wessem, Karlijn, van Gaalen, Steven M., Leenen, Luke, Bronkhorst, Maarten W. G. A., Guicherit, Onno R., Goslings, J. Carel, Nauth, Aaron, Ponsen, Kees Jan, Bhatia, Mahesh, Arora, Vinod, Tyagi, Vivek, Liew, Susan, Bedi, Harvinder, Carr, Ashley, Curry, Hamish, Chia, Andrew, Csongvay, Steve, Vicente, Milena R., Donohue, Craig, Doig, Stephen, Edwards, Elton, Etherington, Greg, Esser, Max, Gong, Andrew, Jain, Arvind, Li, Doug, Miller, Russell, Moaveni, Ash, Perey, Bertrand, Wild, Lisa M., Russ, Matthias, Ton, Lu, Wang, Otis, Dowrick, Adam, Murdoch, Zoe, Sage, Claire, Frihagen, Frede, Clarke-Jenssen, John, Hjorthaug, Geir, Ianssen, Torben, Khan, Ryan M., Amundsen, Asgeir, Brattgjerd, Jan Egil, Borch, Tor, Boe, Berthe, Flatoy, Bernhard, Hasselund, Sondre, Haug, Knut Jorgen, Hemlock, Kim, Hoseth, Tor Magne, Jomaas, Geir, Hidy, Jennifer T., Kibsgard, Thomas, Lona, Tarjei, Moatshe, Gilbert, Muller, Oliver, Molund, Marius, Nicolaisen, Tor, Nilsen, Fredrik, Rydinge, Jonas, Smedsrud, Morten, Stodle, Are, Coles, Chad, Trommer, Axel, Ugland, Stein, Karlsten, Anders, Ekas, Guri, Vesterhus, Elise Berg, Brekke, Anne Christine, Gupta, Ajay, Jain, Neeraj, Khan, Farah, Sharma, Ateet, Leighton, Ross, Sanghavi, Amir, Trivedi, Mittal, Rai, Anil, Subash, Rai, Kamal, Yadav, Vineet, Singh, Sanjay, Tetsworth, Kevin, Donald, Geoff, Biddulph, Michael, Weinrauch, Patrick, Pincus, Paul, Yang, Steven, Halliday, Brett, Gervais, Trevor, Holt, Michael, Flynn, Annette, Prasad, Amal Shankar, Mishra, Vimlesh, Sundaresh, D. C., Johnston, David, Khanna, Angshuman, Cherian, Joe Joseph, Olakkengil, Davy J., Sharma, Gaurav, Pirpiris, Marinis, Love, David, Bucknill, Andrew, Farrugia, Richard J., Pape, Hans-Christoph, Knobe, Matthias, Glazebrook, Mark, Pfeifer, Roman, Hull, Peter, Lewis, Sophie, Evans, Simone, Nanda, Rajesh, Logishetty, Rajanikanth, Anand, Sanjeev, Bowler, Carol, Dadi, Akhil, Palla, Naveen, Alexander, David, Ganguly, Utsav, Rai, B. Sachidananda, Rajakumar, Janakiraman, Jennings, Andrew, Chuter, Graham, Rose, Glynis, Horner, Gillian, Clark, Callum, Eke, Kate, Reed, Mike, Coady, Cathy, Herriott, Chris, Dobb, Christine, Bhandari, Mohit, Swiontkowski, Marc, Devereaux, Pj, Jeray, Kyle, Thabane, Lehana, Stone, Trevor, Dunbar, Michael, Walter, Stephen, Sprague, Sheila, Scott, Taryn, Guyatt, Gordon, Amirault, David, Viveiros, Helena, McKay, Paula, Swinton, Marilyn, Gross, Michael, Truong, Victoria, Koo, Kaitlin, Heels-Ansdell, Diane, Zhou, Qi, Buckingham, Lisa, Duraikannan, Aravin, Maddock, Deborah, Simunovic, Nicole, Agel, Julie, Oxner, William, Van Lieshout, Esther M. M., Zielinski, Stephanie M., Rangan, Amar, Hanusch, Birgit C., Kottam, Lucksy, Clarkson, Rachel, Reardon, Gerald, Slobogean, Gerard, Katz, Jeffrey, Gillespie, Brenda, Greendale, Gail A., Guy, Pierre, Hartman, Curtis, Rubin, Craig, Waddell, James, FAITH Investigators, Richardson, Glen, Trenholm, Andrew, Wong, Ivan, Trask, Kelly, MacDonald, Shelley, Viskontas, Darius, Dobbin, Gwen, Bicknell, Ryan, Yach, Jeff, Bardana, Davide, Wood, Gavin, Harrison, Mark, Yen, David, Lambert, Sue, Howells, Fiona, Ward, Angela, Lemke, H. Michael, Zalzal, Paul, Brien, Heather, Naumetz, V., Weening, Brad, Wai, Eugene K., Papp, Steve, Gofton, Wade T., Liew, Allen, Kingwell, Stephen P., Zomar, Mauri, Johnson, Garth, O'Neil, Joseph, Roffey, Darren M., Borsella, Vivian, Avram, Victoria, Oliver, Todd M., Jones, Vicki, Jones, Clifford B., Ringler, James R., Endres, Terrence J., Moon, Karyn, Sietsema, Debra L., Jeray, Kyle J., Broderick, J. Scott, Goetz, David R., Pace, Thomas B., Schaller, Thomas M., Porter, Scott E., Tanner, Stephanie L., Snider, Rebecca G., Nastoff, Lauren A., Surgery, Emergency Medicine, Obstetrics and Gynaecology, Other Research, Other departments, Graduate School, and AMS - Amsterdam Movement Sciences

Subjects
Time Factors, Sports medicine, medicine.medical_treatment, Bone Screws, Dentistry, Femoral Neck Fractures, law.invention, Fracture Fixation, Internal, Study Protocol, Postoperative Complications, 0302 clinical medicine, Clinical Protocols, Randomized controlled trial, law, Fracture fixation, Orthopedics and Sports Medicine, 030212 general & internal medicine, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Likelihood Functions, 030222 orthopedics, Femoral neck fractures, 3. Good health, Europe, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Treatment Outcome, Research Design, Hip fractures, Sliding hip screw, Reoperation, medicine.medical_specialty, Asia, Prosthesis Design, 03 medical and health sciences, Fixation (surgical), Rheumatology, medicine, Humans, Internal fixation, Proportional Hazards Models, business.industry, Australia, Arthroplasty, Surgery, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], North America, Orthopedic surgery, Quality of Life, Cancellous screws, business
Abstract

Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. The FAITH trial is registered at ClinicalTrials.gov (Identifier NCT00761813 ).

Published
2014
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26. An uncemented iso-elastic monoblock acetabular component: Preliminary results

Author

MS Orthopaedie Algemeen, Infection & Immunity, Halma, Jelle J., Eshuis, Rienk, Vogely, H. Charles, van Gaalen, Steven M., de Gast, Arthur, MS Orthopaedie Algemeen, Infection & Immunity, Halma, Jelle J., Eshuis, Rienk, Vogely, H. Charles, van Gaalen, Steven M., and de Gast, Arthur

Published
2015

32. Relating cell proliferation to in vivo bone formation in porous Ca/P scaffolds.

Author

van Gaalen, Steven M., de Bruijn, Joost D., Wilson, Clayton E., van Blitterswijk, Clemens A., Verbout, Abraham J., Alblas, Jacqueline, and Dhert, Wouter J. A.

Abstract

Most current methods for cell monitoring on 3D porous scaffolds involve end‐stage investigation of scaffolds. Repeated measurements on scaffolds, without disturbing cell vitality and proliferation, are needed to relate in vitro to in vivo data. Alamar Blue™ was used for this purpose. Two different Ca/P scaffolds were studied, using rat BMSCs with three different seeding densities [2.5 × 104 (SD1), 2.5 × 105 (SD2), 2.5 × 106 (SD3) cells]. Alamar Blue™ readings were done on days 1, 3, 5 and 7. After 7 days all 96 scaffolds (n = 16) were implanted in 16 mice for 4 weeks. Bone histomorphometry was performed. For both scaffolds, seeding efficiencies were highest with SD1 and SD2, cell proliferation was optimal in SD1, whereas SD3 resulted in an initial drop in vital cell number in the first 3 days. In vivo, upscaling from SD1 to SD2 lead to significantly more bone contact% in both scaffolds. Alamar Blue™ was shown to be a valuable tool in relating in vitro to in vivo data. Cell proliferation may differ depending on seeding density and scaffold type used. Seeding more cells may not necessarily result in more in vivo bone contact%. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010 [ABSTRACT FROM AUTHOR]

Published
2010
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33. Use of Fluorochrome Labels in In VivoBone Tissue Engineering Research

Author

van Gaalen, Steven M., Kruyt, Moyo C., Geuze, Ruth E., de Bruijn, Joost D., Alblas, Jacqueline, and Dhert, Wouter J.A.

Abstract

The use of fluorochromes in bone research is a widely accepted technique that dates back to the 1950s. Several pioneers, such as Harold Frost, have thoroughly investigated the potential of fluorochrome use for the study on bone formation and bone remodeling dynamics. Since the development of bone tissue engineering, a renewed interest in the benefits of fluorochrome use was perceived. Fluorochrome use in animal models makes it possible to determine the onset time and location of osteogenesis, which are the fundamental parameters in bone tissue engineering studies. There is, however, a lack of standardized procedures for using this technique. In addition, many types of fluorochromes exist and one could be confused upon selecting the appropriate type, the appropriate concentration, the route of administration, and methods of visualization. All these variables can potentially affect the outcome during fluorescence microscopy. This work aims at providing the bone tissue engineering researcher with an overview of the history, working mechanism, and the potential pitfalls in the use of fluorochromes in animal studies. Experiments using some of the more frequently used fluorochromes are explained and illustrated.

Published
2010
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34. Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws on revision surgery rates and quality of life in the treatment of femoral neck fractures

Author

McCormack, Robert, Apostle, Kelly, Boyer, Dory, Moola, Farhad, Perey, Bertrand, Stone, Trevor, Viskontas, Darius, Lemke, H. Michael, Zomar, Mauri, Moon, Karyn, Moon, Raely, Oatt, Amber, Buckley, Richard E., Duffy, Paul, Korley, Robert, Puloski, Shannon, Johnston, Kelly, Powell, James, Carcary, Kimberly, Sanders, David, Lawendy, Abdel, Tieszer, Christina, Stephen, David, Kreder, Hans, Jenkinson, Richard, Nousiainen, Markku, Axelrod, Terry, Murnaghan, John, Nam, Diane, Wadey, Veronica, Yee, Albert, Milner, Katrine, Kunz, Monica, Schemitsch, Emil H., Ahn, Henry, Hall, Jeremy A., McKee, Michael D., Whelan, Daniel B., Nauth, Aaron, Vicente, Milena R., Wild, Lisa M., Khan, Ryan M., Hidy, Jennifer T., Coles, Chad, Leighton, Ross, Biddulph, Michael, Johnston, David, Glazebrook, Mark, Alexander, David, Coady, Cathy, Dunbar, Michael, Amirault, David, Gross, Michael, Oxner, William, Reardon, Gerald, Richardson, Glen, Trenholm, Andrew, Wong, Ivan, Trask, Kelly, MacDonald, Shelley, Dobbin, Gwen, Bicknell, Ryan, Yach, Jeff, Bardana, Davide, Wood, Gavin, Harrison, Mark, Yen, David, Lambert, Sue, Howells, Fiona, Ward, Angela, Zalzal, Paul, Brien, Heather, Naumetz, V., Weening, Brad, Simunovic, Nicole, Wai, Eugene K., Papp, Steve, Gofton, Wade T., Liew, Allen, Kingwell, Stephen P., Johnson, Garth, O'Neil, Joseph, Roffey, Darren M., Borsella, Vivian, Avram, Victoria, Oliver, Todd M., Jones, Vicki, Jones, Clifford B., Ringler, James R., Endres, Terrence J., Sietsema, Debra L., Jeray, Kyle J., Broderick, J. Scott, Goetz, David R., Pace, Thomas B., Schaller, Thomas M., Porter, Scott E., Tanner, Stephanie L., Snider, Rebecca G., Nastoff, Lauren A., Bielby, Shea A., Switzer, Julie A., Cole, Peter A., Anderson, Sarah A., Lafferty, Paul M., Li, Mengnai, Ly, Thuan V., Marston, Scott B., Foley, Amy L., Vang, Sandy, Wright, David M., Marcantonio, Andrew J., Kain, Michael S. H., Iorio, Richard, Specht, Lawrence M., Tilzey, John F., Lobo, Margaret J., Garfi, John S., Vallier, Heather A., Dolenc, Andrea, Robinson, Chalitha, Prayson, Michael J., Laughlin, Richard, Rubino, L. Joseph, May, Jedediah, Rieser, Geoffrey Ryan, Dulaney-Cripe, Liz, Gayton, Chris, Shaer, James, Schrickel, Tyson, Hileman, Barbara, Gorczyca, John T., Gross, Jonathan M., Humphrey, Catherine A., Kates, Stephen, Noble, Krista, McIntyre, Allison W., Pecorella, Kaili, Davis, Craig A., Weinerman, Stewart, Weingarten, Peter, Stull, Philip, Lindenbaum, Stephen, Hewitt, Michael, Schwappach, John, Baker, Janell K., Rutherford, Tori, Newman, Heike, Lieberman, Shane, Finn, Erin, Robbins, Kristin, Hurley, Meghan, Lyle, Lindsey, Mitchell, Khalis, Browner, Kieran, Whatley, Erica, Payton, Krystal, Reeves, Christina, Cannada, Lisa K., Karges, David, Hill, Leslie, Mehta, Samir, Esterhai, John, Ahn, Jaimo, Horan, Annamarie D., McGinnis, Kelly, Kaminski, Christine A., Kowalski, Brynn N., Keeve, Jonathan P., Anderson, Christopher G., McDonald, Michael D., Hoffman, Jodi M., Tarkin, Ivan, Siska, Peter, Gruen, Gary, Evans, Andrew, Farrell, Dana J., Irrgang, James, Luther, Arlene, Cross III., William W., Cass, Joseph R., Sems, Stephen A., Torchia, Michael E., Scrabeck, Tyson, Jenkins, Mark, Dumais, Jules, Romero, Amanda W., Sagebien, Carlos A., Butler, Mark S., Monica, James T., Seuffert, Patricia, Hsu, Joseph R., Ficke, James, Charlton, Michael, Napierala, Matthew, Fan, Mary, Tornetta III., Paul, Tannoury, Chadi, Carlisle, Hope, Silva, Heather, Archdeacon, Michael, Finnan, Ryan, Le, Toan, Wyrick, John, Hess, Shelley, Brennan, Michael L., Probe, Robert, Kile, Evelyn, Mills, Kelli, Clipper, Lydia, Yu, Michelle, Erwin, Katie, Horwitz, Daniel, Strohecker, Kent, Swenson, Teresa K., Aurang, Kamran, Zohman, Gary, Peterson, Brett, Huff, Roger B., Baele, Joseph, Weber, Timothy, Edison, Matt, McBeth, Jessica, Shively, Karl, Ertl, Janos P., Mullis, Brian, Parr, J. Andrew, Worman, Ripley, Frizzell, Valda, Moore, Molly M., Tobias, Erin, Thomas, Emily, DePaolo, Charles J., Alosky, Rachel, Shell, Leslie E., Hampton, Lynne, Shepard, Stephanie, Nanney, Tracy, Cuento, Claudine, Cantu, Robert V., Henderson, Eric R., Eickhoff, Linda S., Hammerberg, E. Mark, Stahel, Philip, Hak, David, Mauffrey, Cyril, Gibula, Douglas, Gissel, Hannah, Henderson, Corey, Zamorano, David P., Tynan, Martin C., Pourmand, Deeba, Lawson, Deanna, Della Rocca, Gregory J., Crist, Brett D., Murtha, Yvonne M., Anderson, Linda K., Linehan, Colleen, Pilling, Lindsey, Lewis, Courtland G., Caminiti, Stephanie, Sullivan, Raymond J., Roper, Elizabeth, Obremskey, William, Kregor, Philip, Richards, Justin E., Stringfellow, Kenya, Dohm, Michael P., Zellar, Abby, Segers, Michiel J. M., Zijl, Jacco A. C., Verhoeven, Bart, Smits, Anke B., De Vries, Jean Paul P. M., Fioole, Bram, Van Der Hoeven, Henk, Theunissen, Evert B. M., De Vries Reilingh, Tammo S., Govaert, Lonneke, Wittich, Philippe, De Brauw, Maurits, Wille, Jan, Go, Peter M. N. Y. M., Ritchie, Ewan D., Wessel, Ronald N., Hammacher, Eric R., Heetveld, Martin J., Visser, Gijs A., Stockmann, Heyn, Silvis, Rob, Snellen, Jaap P., Rijbroek, Bram, Scheepers, Joris J. G., Vermeulen, Erik G. J., Siroen, Michiel P. C., Vuylsteke, Ronald, Brom, Hans L. F., Rijna, Herman, De Rijcke, Piet A. R., Koppert, Cees L., Buijk, Steven E., Groenendijk, Richard P. R., Dawson, Imro, Tetteroo, Geert W. M., Bruijninckx, Milko M. M., Doornebosch, Pascal G., De Graaf, Eelco J. R., Van Der Elst, Maarten, Van Der Pol, Carmen C., Van 'T Riet, Martijne, Karsten, Tom M., De Vries, Mark R., Stassen, Laurents P. S., Schep, Niels W. L., Ben Schmidt, G., Hoffman, W. H., Poolman, Rudolf W., Simons, Maarten P., Van Der Heijden, Frank H. W. M., Willems, W. Jaap, De Meulemeester, Frank R. A. J., Van Der Hart, Cor P., Turckan, Kahn, Festen, Sebastiaan, De Nies, Frank, Haverlag, Robert, Out, Nico J. M., Bosma, Jan, Van Kampen, Albert, Biert, Jan, Van Vugt, Arie B., Edwards, Michael J. R., Blokhuis, Taco J., Frolke, Jan Paul M., Geeraedts, Leo M. G., Gardeniers, Jean W. M., Tan, Edward T. C. H., Poelhekke, Lodewijk M. S. J., De Waal Malefijt, Maarten C., Schreurs, Bart, Roukema, Gert R., Josaputra, Hong A., Keller, Paul, De Rooij, Peter D., Kuiken, Hans, Boxma, Han, Cleffken, Berry I., Liem, Ronald, Rhemrev, Steven J., Bosman, Coks H. R., De Mol Van Otterloo, Alexander, Hoogendoorn, Jochem, De Vries, Alexander C., Meylaerts, Sven A. G., Verhofstad, Michiel H. J., Meijer, Joost, Van Egmond, Teun, Van Der Brand, Igor, Patka, Peter, Eversdijk, Martin G., Peters, Rolf, Den Hartog, Dennis, Van Waes, Oscar J. F., Oprel, Pim, Van Der Vis, Harm M., Campo, Martin, Verhagen, Ronald, Albers, G. H. Robert, Zurcher, Arthur W., Simmermacher, Rogier K. J., Van Mulken, Jeroen, Van Wessem, Karlijn, Van Gaalen, Steven M., Leenen, Luke, Bronkhorst, Maarten W. G. A., Guicherit, Onno R., Goslings, J. Carel, Ponsen, Kees Jan, Bhatia, Mahesh, Arora, Vinod, Tyagi, Vivek, Liew, Susan, Bedi, Harvinder, Carr, Ashley, Curry, Hamish, Chia, Andrew, Csongvay, Steve, Donohue, Craig, Doig, Stephen, Edwards, Elton, Etherington, Greg, Esser, Max, Gong, Andrew, Jain, Arvind, Li, Doug, Miller, Russell, Moaveni, Ash, Russ, Matthias, Ton, Lu, Wang, Otis, Dowrick, Adam, Murdoch, Zoe, Sage, Claire, Frihagen, Frede, Clarke-Jenssen, John, Hjorthaug, Geir, Ianssen, Torben, Amundsen, Asgeir, Brattgjerd, Jan Egil, Borch, Tor, Boe, Berthe, Flatoy, Bernhard, Hasselund, Sondre, Haug, Knut Jorgen, Hemlock, Kim, Hoseth, Tor Magne, Jomaas, Geir, Kibsgard, Thomas, Lona, Tarjei, Moatshe, Gilbert, Muller, Oliver, Molund, Marius, Nicolaisen, Tor, Nilsen, Fredrik, Rydinge, Jonas, Smedsrud, Morten, Stodle, Are, Trommer, Axel, Ugland, Stein, Karlsten, Anders, Ekas, Guri, Vesterhus, Elise Berg, Brekke, Anne Christine, Gupta, Ajay, Jain, Neeraj, Khan, Farah, Sharma, Ateet, Sanghavi, Amir, Trivedi, Mittal, Rai, Anil, Subash, Rai, Kamal, Yadav, Vineet, Singh, Sanjay, Tetsworth, Kevin, Donald, Geoff, Weinrauch, Patrick, Pincus, Paul, Yang, Steven, Halliday, Brett, Gervais, Trevor, Holt, Michael, Flynn, Annette, Prasad, Amal Shankar, Mishra, Vimlesh, Sundaresh, D. C., Khanna, Angshuman, Cherian, Joe Joseph, Olakkengil, Davy J., Sharma, Gaurav, Pirpiris, Marinis, Love, David, Bucknill, Andrew, Farrugia, Richard J., Pape, Hans-Christoph, Knobe, Matthias, Pfeifer, Roman, Hull, Peter, Lewis, Sophie, Evans, Simone, Nanda, Rajesh, Logishetty, Rajanikanth, Anand, Sanjeev, Bowler, Carol, Dadi, Akhil, Palla, Naveen, Ganguly, Utsav, Rai, B. Sachidananda, Rajakumar, Janakiraman, Jennings, Andrew, Chuter, Graham, Rose, Glynis, Horner, Gillian, Clark, Callum, Eke, Kate, Reed, Mike, Herriott, Chris, Dobb, Christine, Bhandari, Mohit, Swiontkowski, Marc, Devereaux, Pj, Jeray, Kyle, Thabane, Lehana, Walter, Stephen, Sprague, Sheila, Scott, Taryn, Guyatt, Gordon, Viveiros, Helena, McKay, Paula, Swinton, Marilyn, Truong, Victoria, Koo, Kaitlin, Heels-Ansdell, Diane, Zhou, Qi, Buckingham, Lisa, Duraikannan, Aravin, Maddock, Deborah, Agel, Julie, Van Lieshout, Esther M. M., Zielinski, Stephanie M., Rangan, Amar, Hanusch, Birgit C., Kottam, Lucksy, Clarkson, Rachel, Slobogean, Gerard, Katz, Jeffrey, Gillespie, Brenda, Greendale, Gail A., Guy, Pierre, Hartman, Curtis, Rubin, Craig, Waddell, James, and FAITH Investigators

Subjects
3. Good health
Abstract

BMC musculoskeletal disorders 15, 219 (2014). doi:10.1186/1471-2474-15-219, Published by BioMed Central, London

35. Comparison of polyetheretherketone versus silicon nitride intervertebral spinal spacers in a caprine model.

Author

Kersten RFMR, Wu G, Pouran B, van der Veen AJ, Weinans HH, de Gast A, Öner FC, and van Gaalen SM

Subjects
Animals, Benzophenones, Female, Goats, Lumbar Vertebrae metabolism, Lumbar Vertebrae pathology, Lumbar Vertebrae surgery, Osteogenesis, Polymers, Silicon Compounds, Biocompatible Materials chemistry, Implants, Experimental, Ketones chemistry, Lumbar Vertebrae chemistry, Polyethylene Glycols chemistry, Spinal Fusion
Abstract

Polyetheretherketone (PEEK) is commonly used as a spinal spacer for intervertebral fusion surgery. Unfortunately, PEEK is bioinert and does not effectively osseointegrate into living bone. In contrast, comparable spacers made of silicon nitride (Si 3 N 4 ) possess a surface nanostructure and chemistry that encourage appositional bone healing. This observational study was designed to compare the outcomes of these two biomaterials when implanted as spacers in an adult caprine model. Lumbar interbody fusion surgeries were performed at two adjacent levels in eight adult goats using implants of PEEK and Si 3 N 4 . At six-months after surgery, the operative and adjacent spinal segments were extracted and measured for bone fusion, bone volume, bone-implant contact (BIC) and soft-tissue implant contact (SIC) ratios, and biodynamic stability. The null hypothesis was that no differences in these parameters would be apparent between the two groups. Fusion was observed in seven of eight implants in each group with greater bone formation in the Si 3 N 4 group (52.6%) versus PEEK (27.9%; p = 0.2). There were no significant differences in BIC ratios between PEEK and Si 3 N 4 , and the biodynamic stability of the two groups was also comparable. The results suggest that Si 3 N 4 spacers are not inferior to PEEK and they may be more effective in promoting arthrodesis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 00B: 000-000, 2018. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 688-699, 2019., (© 2018 Wiley Periodicals, Inc.)

Published
2019
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36. Temporary Segmental Distraction in a Dog with Degenerative Lumbosacral Stenosis.

Author

Willems N, Kersten RFMR, van Gaalen SM, Öner FC, Strijkers GJ, Veraa S, Beukers M, Tryfonidou MA, and Meij BP

Subjects
Animals, Constriction, Pathologic, Dogs, Intervertebral Disc Degeneration surgery, Lumbar Vertebrae, Spinal Fusion, Spinal Stenosis surgery, Treatment Outcome, Dog Diseases surgery, Intervertebral Disc Degeneration veterinary, Lumbosacral Region surgery, Pedicle Screws veterinary, Spinal Stenosis veterinary
Abstract

Objectives:  Degenerative lumbosacral stenosis (DLSS) is characterized by intervertebral disc degeneration and causes lower back pain in dogs. Temporary distraction in rabbit models with induced intervertebral disc degeneration showed signs of intervertebral disc repair. In the present study, we assessed safety and efficacy of temporary segmental distraction in a dog with clinical signs of DLSS., Methods:  Distraction of the lumbosacral junction by pedicle screw-rod fixation was applied in a 5-year-old Greyhound with DLSS and evaluated by radiography, magnetic resonance imaging, and force plate analysis before and after distraction., Results:  Safe distraction of the lumbosacral junction was demonstrated, with improvement of clinical signs after removal of the distraction device. Signal intensity of the intervertebral disc showed no changes over time. T2 value was highest directly after removal of the distraction device but decreased by 10% of the preoperative value at 9 months of follow-up. Disc height decreased (8%) immediately after removal of the distraction device, but recovered to the initial value. A decrease in the pelvic/thoracic propulsive force during pedicle screw-rod fixation and distraction was demonstrated, which slowly increased by 4% compared with the initial value., Clinical Significance:  Temporary pedicle screw-rod fixation in combination with distraction in a dog with DLSS was safe, improved clinical signs and retained disc height at 9 months of follow-up., Competing Interests: None., (Georg Thieme Verlag KG Stuttgart · New York.)

Published
2018
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