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3. Cost-effectiveness of Diagnostic Testing Strategies Including Cervical-Length Measurement and Fibronectin Testing in Women With Symptoms of Preterm Labor

Author

van Baaren, G.-J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C. J., Spaanderman, M. E. A., Bloemenkamp, K. W. M., Haak, M. C., Bax, C. J., Cornette, J. M. J., Duvekot, J. J., Nij Bijvanck, B. W. A., van Eyck, J., Franssen, M. T. M., Sollie, K. M., Vandenbussche, F. P. H. A., Woiski, M., Bolte, A. C., van der Post, J. A. M., Bossuyt, P. M. M., Opmeer, B. C., and Mol, B. W. J.

Published
2018
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4. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Brezinka, C., Derks, J.B., Diemert, A., Duvekot, J.J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A.T., Schlembach, D., Schneider, K.T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A, Visser, G.H.A., Aktas, A., Borgione, S., Chaoui, R., Cornette, J.M.J., Diehl, T., van Eyck, J, Fratelli, N., van Haastert, I.C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M, Oepkes, D., Ogge, G., van der Post, J.A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I.K.M., Scheepers, L.S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., and Lees, Christoph

Published
2017
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8. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

Author

Lees, C., Marlow, N., Arabin, B., Bilardo, C. M., Brezinka, C., Derks, J. B., Duvekot, J., Frusca, T., Diemert, A., Ferrazzi, E., Ganzevoort, W., Hecher, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T. M., Thilaganathan, B., Todros, T., van Wassenaer-Leemhuis, A., Valcamonico, A., Visser, G. H. A., Wolf, H., Scheepers, H. C. J., Spaanderman, M., Calvert, S., Missfelder-Lobos, H., van Eyck, J., Oepkes, D., Fratelli, N., Prefumo, F., Napolitano, R., Chaoui, R., Maso, G., Ogge, G., Oberto, M., and van Charante, Mensing N.

Published
2013
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12. Neurodevelopmental outcomes at five years after early-onset fetal growth restriction: Analyses in a Dutch subgroup participating in a European management trial

Author

Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., van Wassenaer-Leemhuis, A. G., Kinderbewegingszorg patientenzorg, Brain, MS Neonatologie, UMC Utrecht, MS Verloskunde, Other research (not in main researchprogram), Pels, A., Knaven, O. C., Wijnberg-Williams, B. J., Eijsermans, M. J.C., Mulder-de Tollenaer, S. M., Aarnoudse-Moens, C. S.H., Koopman-Esseboom, C., van Eyck, J., Derks, J. B., Ganzevoort, W., and van Wassenaer-Leemhuis, A. G.

Published
2019

18. Neurodevelopmental Outcomes at Five Years After Early-Onset Fetal Growth Restriction: Analyses in a Dutch Subgroup Participating in a European Management Trial

Author

Pels, A., primary, Knaven, O. C., additional, Wijnberg-Williams, B. J., additional, Eijsermans, M. J. C., additional, Mulder-de Tollenaer, S. M., additional, Aarnoudse-Moens, C. S. H., additional, Koopman-Esseboom, C., additional, van Eyck, J., additional, Derks, J. B., additional, Ganzevoort, W., additional, and van Wassenaer-Leemhuis, A. G., additional

Published
2019
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21. Cost-effectiveness of diagnostic testing strategies including cervical-length measurement and fibronectin testing in women with symptoms of preterm labor

Author

van Baaren, G. J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., Vandenbussche, F. P.H.A., Woiski, M., Bolte, A. C., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., Mol, B. W.J., van Baaren, G. J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., Vandenbussche, F. P.H.A., Woiski, M., Bolte, A. C., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., and Mol, B. W.J.

Published
2018

22. Cost-effectiveness of diagnostic testing strategies including cervical-length measurement and fibronectin testing in women with symptoms of preterm labor

Author

UMC Utrecht, CDL Klinisch Chemici in opleiding, MS Verloskunde, Other research (not in main researchprogram), Geboortecentrum voorzitterschap, van Baaren, G. J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., Vandenbussche, F. P.H.A., Woiski, M., Bolte, A. C., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., Mol, B. W.J., UMC Utrecht, CDL Klinisch Chemici in opleiding, MS Verloskunde, Other research (not in main researchprogram), Geboortecentrum voorzitterschap, van Baaren, G. J., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., Vandenbussche, F. P.H.A., Woiski, M., Bolte, A. C., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., and Mol, B. W.J.

Published
2018

23. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study

Author

Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, and Rattue, H.

Subjects
ductus venosus, fetal growth restriction, Radiological and Ultrasound Technology, Reproductive Medicine, Radiology Nuclear Medicine and imaging, Obstetrics and Gynaecology, Journal Article, cardiotocography, preterm delivery, fetal heart rate variation
Abstract

Objective: In the TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe) study on the outcome of early fetal growth restriction, women were allocated to one of three groups of indication for delivery according to the following monitoring strategies: (1) reduced fetal heart rate (FHR) short-term variation (STV) on cardiotocography (CTG); (2) early changes in fetal ductus venosus (DV) waveform (DV-p95); and (3) late changes in fetal DV waveform (DV-no-A). However, many infants per monitoring protocol were delivered because of safety-net criteria, for maternal or other fetal indications, or after 32 weeks of gestation when the protocol was no longer applied. The objective of the present posthoc subanalysis was to investigate the indications for delivery in relation to 2-year outcome in infants delivered before 32 weeks to further refine management proposals. Methods: We included all 310 cases of the TRUFFLE study with known outcome at 2 years' corrected age and seven fetal deaths, excluding seven cases with inevitable perinatal death. Data were analyzed according to the allocated fetal monitoring strategy in combination with the indication for delivery. Results: Overall, only 32% of liveborn infants were delivered according to the specified monitoring parameter for indication for delivery; 38% were delivered because of safety-net criteria, 15% for other fetal reasons and 15% for maternal reasons. In the CTG-STV group, 51% of infants were delivered because of reduced STV. In the DV-p95 group, 34% of infants were delivered because of abnormal DV and, in the DV-no-A group, only 10% of infants were delivered accordingly. The majority of infants in the DV groups were delivered for the safety-net criterion of spontaneous decelerations in FHR. Two-year intact survival was highest in the DV groups combined compared with the CTG-STV group (P = 0.05 for live births only, P = 0.21 including fetal death), with no difference between DV groups. A poorer outcome in the CTG-STV group was restricted to infants delivered because of FHR decelerations in the safety-net subgroup. Infants delivered because of maternal reasons had the highest birth weight and a non-significantly higher intact survival. Conclusions: In this subanalysis of infants delivered before 32 weeks, the majority were delivered for reasons other than the allocated monitoring strategy indication. Since, in the DV group, CTG-STV criteria were used as a safety net but in the CTG-STV group, no DV safety-net criteria were applied, we speculate that the slightly poorer outcome in the CTG-STV group might be explained by the absence of DV data. The optimal timing of delivery of fetuses with early intrauterine growth restriction may therefore be best determined by monitoring them longitudinally, with both DV and CTG monitoring.

Published
2017

24. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks : post-hoc analysis of TRUFFLE study

Author

Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Subjects
ductus venosus, fetal growth restriction, intrauterine growth restriction, Radiological and Ultrasound Technology, Reproductive Medicine, Radiology Nuclear Medicine and imaging, Obstetrics and Gynaecology, Journal Article, cardiotocography
Abstract

Objectives: In the recent TRUFFLE study, it appeared that, in pregnancies complicated by fetal growth restriction (FGR) between 26 and 32 weeks' gestation, monitoring of the fetal ductus venosus (DV) waveform combined with computed cardiotocography (CTG) to determine timing of delivery increased the chance of infant survival without neurological impairment. However, concerns with the interpretation were raised, as DV monitoring appeared to be associated with a non-significant increase in fetal death, and some infants were delivered after 32 weeks, at which time the study protocol no longer applied. This secondary sensitivity analysis of the TRUFFLE study focuses on women who delivered before 32 completed weeks' gestation and analyzes in detail the cases of fetal death. Methods: Monitoring data of 317 pregnancies with FGR that delivered before 32 weeks were analyzed, excluding those with absent outcome data or inevitable perinatal death. Women were allocated randomly to one of three groups of indication for delivery according to the following monitoring strategies: (1) reduced fetal heart rate short-term variation (STV) on CTG; (2) early changes in fetal DV waveform; and (3) late changes in fetal DV waveform. Primary outcome was 2-year survival without neurological impairment. The association of the last monitoring data before delivery and infant outcome was assessed by multivariable analysis. Results: Two-year survival without neurological impairment occurred more often in the two DV groups (both 83%) than in the CTG-STV group (77%), however, the difference was not statistically significant (P = 0.21). Among the surviving infants in the DV groups, 93% were free of neurological impairment vs 85% of surviving infants in the CTG-STV group (P = 0.049). All fetal deaths (n = 7) occurred in the groups with DV monitoring. Of the monitoring parameters obtained shortly before fetal death in these seven cases, an abnormal CTG was observed in only one case. Multivariable regression analysis of factors at study entry demonstrated that a later gestational age, higher estimated fetal weight-to-50th percentile ratio and lower umbilical artery pulsatility index (PI)/fetal middle cerebral artery-PI ratio were significantly associated with normal outcome. Allocation to DV monitoring had a smaller effect on outcome, but remained in the model (P < 0.1). Abnormal fetal arterial Doppler before delivery was significantly associated with adverse outcome in the CTG-STV group. In contrast, abnormal DV flow was the only monitoring parameter associated with adverse outcome in the DV groups, while fetal arterial Doppler, STV below the cut-off used in the CTG-STV group and recurrent decelerations in fetal heart rate were not. Conclusions: In accordance with the findings of the TRUFFLE study on monitoring and intervention management of very preterm FGR, we found that the proportion of infants surviving without neuroimpairment was not significantly different when the decision for delivery was based on changes in DV waveform vs reduced STV on CTG. The uneven distribution of fetal deaths towards the DV groups was probably a chance effect, and neurological outcome was better among surviving children in these groups. Before 32 weeks, delaying delivery until abnormalities in DV-PI or STV and/or recurrent decelerations in fetal heat rate occur, as defined by the study protocol, is likely to be safe and possibly benefits long-term outcome.

Published
2017

25. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study

Author

Visser, Gha, Bilardo, Cm, Derks, Jb, Ferrazzi, E, Fratelli, N, Frusca, T, Ganzevoort, W, Lees, Cc, Napolitano, R, Todros, T, Wolf, H, Hecher, K, Marlow, N, Arabin, B, Brezinka, C, Diemert, A, Duvekot, Jj, Martinelli, P, Ostermayer, E, Papageorghiou, At, Schlembach, D, Schneider, Ktm, Thilaganathan, B, Valcamonico, A, Aktas, A, Borgione, S, Chaoui, R, Cornette, Jmj, Diehl, T, van Eyck, J, van Haastert, Ic, Kingdom, J, Lobmaier, S, Lopriore, E, Missfelder-Lobos, H, Mansi, G, Martelli, P, Maso, G, Marsal, K, Maurer-Fellbaum, U, Mensing van Charante, N, Mulder-de Tollenaer, S, Oberto, M, Oepkes, D, Ogge, G, van der Post, Jam, Prefumo, F, Preston, L, Raimondi, F, Rattue, H, Reiss, Ikm, Scheepers, Ls, Skabar, A, Spaanderman, M, Thornton, J, Valensise, H, Weisglas-Kuperus, N, and Zimmermann, A

Subjects
Male, cardiotocography, ductus venosus, fetal growth restriction, fetal heart rate variation, preterm delivery, Cardiotocography, Female, Fetal Growth Retardation, Fetus, Gestational Age, Humans, Infant, Newborn, Netherlands, Pregnancy, Pregnancy Outcome, Pulsatile Flow, Survival Analysis, Umbilical Arteries, Delivery, Obstetric, Fetal Monitoring, Ultrasonography, Prenatal, Prenatal, Ultrasonography, Infant, Obstetric, Newborn, Settore MED/40, Delivery
Abstract

In the TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe) study on the outcome of early fetal growth restriction, women were allocated to one of three groups of indication for delivery according to the following monitoring strategies: (1) reduced fetal heart rate (FHR) short-term variation (STV) on cardiotocography (CTG); (2) early changes in fetal ductus venosus (DV) waveform (DV-p95); and (3) late changes in fetal DV waveform (DV-no-A). However, many infants per monitoring protocol were delivered because of safety-net criteria, for maternal or other fetal indications, or after 32 weeks of gestation when the protocol was no longer applied. The objective of the present posthoc subanalysis was to investigate the indications for delivery in relation to 2-year outcome in infants delivered before 32 weeks to further refine management proposals.We included all 310 cases of the TRUFFLE study with known outcome at 2 years' corrected age and seven fetal deaths, excluding seven cases with inevitable perinatal death. Data were analyzed according to the allocated fetal monitoring strategy in combination with the indication for delivery.Overall, only 32% of liveborn infants were delivered according to the specified monitoring parameter for indication for delivery; 38% were delivered because of safety-net criteria, 15% for other fetal reasons and 15% for maternal reasons. In the CTG-STV group, 51% of infants were delivered because of reduced STV. In the DV-p95 group, 34% of infants were delivered because of abnormal DV and, in the DV-no-A group, only 10% of infants were delivered accordingly. The majority of infants in the DV groups were delivered for the safety-net criterion of spontaneous decelerations in FHR. Two-year intact survival was highest in the DV groups combined compared with the CTG-STV group (P = 0.05 for live births only, P = 0.21 including fetal death), with no difference between DV groups. A poorer outcome in the CTG-STV group was restricted to infants delivered because of FHR decelerations in the safety-net subgroup. Infants delivered because of maternal reasons had the highest birth weight and a non-significantly higher intact survival.In this subanalysis of infants delivered before 32 weeks, the majority were delivered for reasons other than the allocated monitoring strategy indication. Since, in the DV group, CTG-STV criteria were used as a safety net but in the CTG-STV group, no DV safety-net criteria were applied, we speculate that the slightly poorer outcome in the CTG-STV group might be explained by the absence of DV data. The optimal timing of delivery of fetuses with early intrauterine growth restriction may therefore be best determined by monitoring them longitudinally, with both DV and CTG monitoring. Copyright © 2016 ISUOG. Published by John WileySons Ltd.

Published
2017

26. Longitudinal study of computerized cardiotocography in early fetal growth restriction

Author

Wolf, H., Arabin, B., Lees, C. C., Oepkes, D., Prefumo, F., Thilaganathan, B., Todros, T., Visser, G. H. A., Bilardo, C. M., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Scheepers, H. C. J., Schlembach, D., Schneider, K. T. M., Valcamonico, A., van Wassenaer-Leemhuis, A., Ganzevoort, W., Aktas, A., Borgione, S., Brezinka, C., Calvert, S., Chaoui, R., Cornette, J. M. J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. -L., Johnson, S., Lobmaier, S., Lopriore, E., Mansi, G., Missfelder-Lobos, H., Martelli, P., Maso, G., Maurer-Fellbaum, U., van Charante, N. M., De Tollenaer, S. M., Moore, T., Napolitano, R., Oberto, M., Ogge, G., van der Post, J., Preston, L., Raimondi, F., Reiss, I. K. M., Rigano, S., Schuit, E., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Subjects
ductus venosus, fetal growth restriction, fetal monitoring, short-term variation, cardiotocography, preterm
Published
2017

27. Motor Development and Learning Difficulties. Part One.

Author

van Eyck, J. W. L.

Abstract

The article discusses stimulating motor development as it relates to learning difficulties with reference to the work of Dutch neurologist P. Mesker. It is concluded that disturbance in sensorimotor development is the most important cause of learning difficulties in the first years of elementary school. (SBH)

Published
1980

28. Motor Development and Learning Difficulties. Part Two.

Author

van Eyck, J. W. L.

Abstract

Part Two of the article focuses on the development of manual motor skills in learning disabled children. After a discussion of test methods, the author considers aspects of a medical examination, including a general exam, a neurological exam, an electroencephalogram, and a diagnostic test of hand/motor skill development. (For Part One, see EC 123 286.) (PHR)

Published
1980

30. Cost-effectiveness of diagnostic testing strategies including cervical-length measurement and fibronectin testing in women with symptoms of preterm labor

Author

van Baaren, G.-J., primary, Vis, J. Y., additional, Wilms, F. F., additional, Oudijk, M. A., additional, Kwee, A., additional, Porath, M. M., additional, Scheepers, H. C. J., additional, Spaanderman, M. E. A., additional, Bloemenkamp, K. W. M., additional, Haak, M. C., additional, Bax, C. J., additional, Cornette, J. M. J., additional, Duvekot, J. J., additional, Nij Bijvanck, B. W. A., additional, van Eyck, J., additional, Franssen, M. T. M., additional, Sollie, K. M., additional, Vandenbussche, F. P. H. A., additional, Woiski, M., additional, Bolte, A. C., additional, van der Post, J. A. M., additional, Bossuyt, P. M. M., additional, Opmeer, B. C., additional, and Mol, B. W. J., additional

Published
2018
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31. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

32. STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

Author

Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, A, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, McCowan, LM, Stone, PR, Lee, A, Mackay, L, Oyston, C, Gardener, G, Khashan, A, Eustace, J, Dempsey, E, Jackson, R, Dickinson, J, Gill, A, Muller, P, Sekar, R, Reid, RA, Unterschneider, J, Welsh, A, Marlow, J, Hyett, J, Walker, S, Morris, J, Watson, D, McKinlay, C, Harris, S, Lim, KI, Lalji, S, Magee, LA, Lee, T, Li, J, Hutfield, A, Ansermino, M, Robinson, W, Singer, J, Synnes, AR, Burrows, J, Audibert, F, Bujold, E, Piedboeuf, B, Davidge, ST, Seaward, GR, Dwinnell, S, Gagnon, R, Gaudet, L, Young, C, Murphy, D, Daly, S, McAuliffe, F, Malone, F, Breathnach, F, O'Donoghue, K, Al-Nasiry, S, de Boer, MA, de Groot, CJM, Sueters, M, Derks, JB, van Drongelen, J, Duvekot, HJ, Elvan-Taspinar, A, van Eyck, J, van Laar, J, Morssink, LP, Price, L, Astor, A, Hardman, L, Sharp, A, Turner, M, Cameron, A, Draper, E, Clarke, P, Mckelvey, A, Masson, G, Aquilin, J, Johnstone, E, Bugg, G, Howe, D, Patni, S, Mousa, H, Russell, H, Hannon, T, Kilby, M, David, A, Cohen, K, Impey, L, Stock, S, Poon, L, Pasupath, D, Khalil, A, Pels, A, Kenny, LC, Alfirevic, Z, Baker, PN, von Dadelszen, P, Gluud, C, Kariya, CT, Mol, BW, Papageorghiou, A, van Wassenaer-Leemhuis, AG, Ganzevoort, W, Groom, KM, McCowan, LM, Stone, PR, Lee, A, Mackay, L, Oyston, C, Gardener, G, Khashan, A, Eustace, J, Dempsey, E, Jackson, R, Dickinson, J, Gill, A, Muller, P, Sekar, R, Reid, RA, Unterschneider, J, Welsh, A, Marlow, J, Hyett, J, Walker, S, Morris, J, Watson, D, McKinlay, C, Harris, S, Lim, KI, Lalji, S, Magee, LA, Lee, T, Li, J, Hutfield, A, Ansermino, M, Robinson, W, Singer, J, Synnes, AR, Burrows, J, Audibert, F, Bujold, E, Piedboeuf, B, Davidge, ST, Seaward, GR, Dwinnell, S, Gagnon, R, Gaudet, L, Young, C, Murphy, D, Daly, S, McAuliffe, F, Malone, F, Breathnach, F, O'Donoghue, K, Al-Nasiry, S, de Boer, MA, de Groot, CJM, Sueters, M, Derks, JB, van Drongelen, J, Duvekot, HJ, Elvan-Taspinar, A, van Eyck, J, van Laar, J, Morssink, LP, Price, L, Astor, A, Hardman, L, Sharp, A, Turner, M, Cameron, A, Draper, E, Clarke, P, Mckelvey, A, Masson, G, Aquilin, J, Johnstone, E, Bugg, G, Howe, D, Patni, S, Mousa, H, Russell, H, Hannon, T, Kilby, M, David, A, Cohen, K, Impey, L, Stock, S, Poon, L, Pasupath, D, and Khalil, A

Abstract

Background: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis. Methods: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation. Discussion: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis.

Published
2017

33. Fetal monitoring indications for delivery and 2-year outcome in 310 infants with fetal growth restriction delivered before 32 weeks' gestation in the TRUFFLE study

Author

MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Rattue, H., TRUFFLE group investigators, MS Verloskunde, UMC Utrecht, Other research (not in main researchprogram), MS Neonatologie, Brain, Visser, G.H.A., Bilardo, Caterina M., Derks, J. B., Ferrazzi, E., Fratelli, Nicola, Frusca, T., Ganzevoort, W., Lees, Christoph C., Napolitano, Raffaele, Todros, T., Wolf, H., Hecher, K., Marlow, N., Arabin, B., Brezinka, C., Diemert, A., Duvekot, Johannes J., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Thilaganathan, B., Valcamonico, A., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., van Haastert, I. C., Kingdom, J.C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Marsal, K., Maurer-Fellbaum, Ute, Mensing van Charante, N., Mulder-De Tollenaer, Susanne, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Prefumo, Federico, Preston, Lucy, Raimondi, Francesco, Rattue, H., and TRUFFLE group investigators

Published
2017

34. How to monitor pregnancies complicated by fetal growth restriction and delivery before 32 weeks: post-hoc analysis of TRUFFLE study

Author

MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, on behalf of the TRUFFLE Group, MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Ganzevoort, W., Mensing van Charante, N., Thilaganathan, B., Prefumo, Federico, Arabin, B., Bilardo, Caterina M., Brezinka, C., Derks, J. B., Diemert, A., Duvekot, Johannes J., Ferrazzi, E., Frusca, T., Hecher, K., Marlow, N., Martinelli, P., Ostermayer, E., Papageorghiou, Aris T., Schlembach, D., Schneider, K. T M, Todros, T., Valcamonico, A., Visser, G. H.A., van Wassenaer-Leemhuis, A., Lees, Christoph C., Wolf, H., Aktas, Ayse, Borgione, Silvia, Chaoui, Rabih, Cornette, Jerome M J, Diehl, Thilo, van Eyck, J., Fratelli, Nicola, van Haastert, I. C., Lobmaier, Silvia, Lopriore, E., Missfelder-Lobos, Hannah, Mansi, Giuseppina, Martelli, Paola, Maso, Gianpaolo, Maurer-Fellbaum, Ute, Mulder-De Tollenaer, Susanne, Napolitano, Raffaele, Oberto, Manuela, Oepkes, D., Ogge, Giovanna, van der Post, Joris A. M., Preston, Lucy, Raimondi, Francesco, Rattue, H., Reiss, Irwin K M, and on behalf of the TRUFFLE Group

Published
2017

35. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., Zimmermann, A., MS Verloskunde, Other research (not in main researchprogram), MS Neonatologie, Brain, Stampalija, Tamara, Arabin, Birgit, Wolf, Hans, Bilardo, Caterina M., Lees, Christoph, Brezinka, C., Derks, J. B., Diemert, A., Duvekot, J. J., Ferrazzi, E., Frusca, T., Ganzevoort, W., Hecher, K., Kingdom, J., Marlow, N., Marsal, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Thornton, J., Todros, T., Valcamonico, A., Valensise, H., van Wassenaer-Leemhuis, A., Visser, GHA, Aktas, A., Borgione, S., Chaoui, R., Cornette, J. M.J., Diehl, T., van Eyck, J., Fratelli, N., van Haastert, I. C., Lobmaier, S., Lopriore, E., Missfelder-Lobos, H., Mansi, G., Martelli, P., Maso, G., Maurer-Fellbaum, U., Mensing van Charante, N., Mulder-de Tollenaer, S., Napolitano, R., Oberto, M., Oepkes, D., Ogge, G., van der Post, J. A.M., Prefumo, F., Preston, L., Raimondi, F., Reiss, I. K.M., Scheepers, L. S., Skabar, A., Spaanderman, M., Weisglas-Kuperus, N., and Zimmermann, A.

Published
2017

37. Maintenance Tocolysis With Nifedipine in Threatened Preterm Labour: 2-Year Follow-up of the Offspring in the APOSTEL II Trial

Author

van Vliet, E., primary, Seinen, L., additional, Roos, C., additional, Schuit, E., additional, Scheepers, H., additional, Bloemenkamp, K., additional, Duvekot, J.J., additional, van Eyck, J., additional, Kok, J.H., additional, Lotgering, F.K., additional, van Baar, A., additional, van Wassenaer-Leemhuis, A.G., additional, Franssen, M.T., additional, Porath, M.M., additional, van der Post, J., additional, Franx, A., additional, Mol, B., additional, and Oudijk, M.A., additional

Published
2017
Full Text
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38. Is middle cerebral artery Doppler related to neonatal and 2-year infant outcome in early fetal growth restriction?

Author

Stampalija, Tamara, primary, Arabin, Birgit, additional, Wolf, Hans, additional, Bilardo, Caterina M., additional, Lees, Christoph, additional, Brezinka, C., additional, Derks, J.B., additional, Diemert, A., additional, Duvekot, J.J., additional, Ferrazzi, E., additional, Frusca, T., additional, Ganzevoort, W., additional, Hecher, K., additional, Kingdom, J., additional, Marlow, N., additional, Marsal, K., additional, Martinelli, P., additional, Ostermayer, E., additional, Papageorghiou, A.T., additional, Schlembach, D., additional, Schneider, K.T.M., additional, Thilaganathan, B., additional, Thornton, J., additional, Todros, T., additional, Valcamonico, A., additional, Valensise, H., additional, van Wassenaer-Leemhuis, A, additional, Visser, G.H.A., additional, Aktas, A., additional, Borgione, S., additional, Chaoui, R., additional, Cornette, J.M.J., additional, Diehl, T., additional, van Eyck, J, additional, Fratelli, N., additional, van Haastert, I.C., additional, Lobmaier, S., additional, Lopriore, E., additional, Missfelder-Lobos, H., additional, Mansi, G., additional, Martelli, P., additional, Maso, G., additional, Maurer-Fellbaum, U., additional, Mensing van Charante, N., additional, Mulder-de Tollenaer, S., additional, Napolitano, R., additional, Oberto, M, additional, Oepkes, D., additional, Ogge, G., additional, van der Post, J.A.M., additional, Prefumo, F., additional, Preston, L., additional, Raimondi, F., additional, Reiss, I.K.M., additional, Scheepers, L.S., additional, Skabar, A., additional, Spaanderman, M., additional, Weisglas-Kuperus, N., additional, and Zimmermann, A., additional

Published
2017
Full Text
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39. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

Author

Bruijn, Mmc, Vis, J Y, Wilms, F F, Oudijk, M A, Kwee, A, Porath, M M, Oei, G, Scheepers, Hcj, Spaanderman, Mea, Bloemenkamp, Kwm, Haak, M C, Bolte, A C, Vandenbussche, Fpha, Woiski, M D, Bax, C J, Cornette, Jmj, Duvekot, J J, Nij Bijvanck, Bwa, van Eyck, J, Franssen, Mtm, Sollie, K M, van der Post, Jam, Bossuyt, Pmm, Opmeer, B C, Kok, M., Mol, Bwj, van Baaren, G-J, Bruijn, Mmc, Vis, J Y, Wilms, F F, Oudijk, M A, Kwee, A, Porath, M M, Oei, G, Scheepers, Hcj, Spaanderman, Mea, Bloemenkamp, Kwm, Haak, M C, Bolte, A C, Vandenbussche, Fpha, Woiski, M D, Bax, C J, Cornette, Jmj, Duvekot, J J, Nij Bijvanck, Bwa, van Eyck, J, Franssen, Mtm, Sollie, K M, van der Post, Jam, Bossuyt, Pmm, Opmeer, B C, Kok, M., Mol, Bwj, and van Baaren, G-J

Published
2016

40. Maintenance tocolysis with nifedipine in threatened preterm labour : 2-year follow up of the offspring in the APOSTEL II trial

Author

van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

41. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, Oudijk, Ma, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Van Vliet, Eog, Seinen, L, Roos, C, Schuit, E, Scheepers, Hcj, Bloemenkamp, Kwm, Duvekot, Jj, Van Eyck, J, Kok, Jh, Lotgering, Fk, Van Baar, A, Van Wassenaer-leemhuis, Ag, Franssen, Mt, Porath, Mm, Van Der Post, Jam, Franx, A, Mol, Bwj, and Oudijk, Ma

Published
2016

42. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

Author

Bruijn, M. M.C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Oei, G., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bolte, A. C., Vandenbussche, F. P.H.A., Woiski, M. D., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., Kok, M., Mol, B. W.J., van Baaren, G. J., Bruijn, M. M.C., Vis, J. Y., Wilms, F. F., Oudijk, M. A., Kwee, A., Porath, M. M., Oei, G., Scheepers, H. C.J., Spaanderman, M. E.A., Bloemenkamp, K. W.M., Haak, M. C., Bolte, A. C., Vandenbussche, F. P.H.A., Woiski, M. D., Bax, C. J., Cornette, J. M.J., Duvekot, J. J., Nij Bijvanck, B. W.A., van Eyck, J., Franssen, M. T.M., Sollie, K. M., van der Post, J. A.M., Bossuyt, P. M.M., Opmeer, B. C., Kok, M., Mol, B. W.J., and van Baaren, G. J.

Abstract

Objective: To evaluate whether in symptomatic women, the combination of quantitative fetal fibronectin (fFN) testing and cervical length (CL) improves the prediction of preterm delivery (PTD) within 7 days compared with qualitative fFN and CL. Design: Post hoc analysis of frozen fFN samples of a nationwide cohort study. Setting: Ten perinatal centres in the Netherlands. Population: Symptomatic women between 24 and 34 weeks of gestation. Methods: The risk of PTD <7 days was estimated in predefined CL and fFN strata. We used logistic regression to develop a model including quantitative fFN and CL, and one including qualitative fFN (threshold 50 ng/ml) and CL. We compared the models’ capacity to identify women at low risk (<5%) for delivery within 7 days using a reclassification table. Main outcome measures: Spontaneous delivery within 7 days after study entry. Results: We studied 350 women, of whom 69 (20%) delivered within 7 days. The risk of PTD in <7 days ranged from 2% in the lowest fFN group (<10 ng/ml) to 71% in the highest group (>500 ng/ml). Multivariable logistic regression showed an increasing risk of PTD in <7 days with rising fFN concentration [10–49 ng/ml: odds ratio (OR) 1.3, 95% confidence interval (95% CI) 0.23–7.0; 50–199 ng/ml: OR 3.2, 95% CI 0.79–13; 200–499 ng/ml: OR 9.0, 95% CI 2.3–35; >500 ng/ml: OR 39, 95% CI 9.4–164] and shortening of the CL (OR 0.86 per mm, 95% CI 0.82–0.90). Use of quantitative fFN instead of qualitative fFN resulted in reclassification of 18 (5%) women from high to low risk, of whom one (6%) woman delivered within 7 days. Conclusion: In symptomatic women, quantitative fFN testing does not improve the prediction of PTD within 7 days compared with qualitative fFN testing in combination with CL measurement in terms of reclassification from high to low (<5%) risk, but it adds value across the risk range. Tweetable abstract: Quantitative fFN testing adds value to qualitative fFN testing with CL measurem

Published
2016

43. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

Author

CDL Klinisch Chemici in opleiding, Circulatory Health, Other research (not in main researchprogram), MS Verloskunde, Bruijn, Mmc, Vis, J Y, Wilms, F F, Oudijk, M A, Kwee, A, Porath, M M, Oei, G, Scheepers, Hcj, Spaanderman, Mea, Bloemenkamp, Kwm, Haak, M C, Bolte, A C, Vandenbussche, Fpha, Woiski, M D, Bax, C J, Cornette, Jmj, Duvekot, J J, Nij Bijvanck, Bwa, van Eyck, J, Franssen, Mtm, Sollie, K M, van der Post, Jam, Bossuyt, Pmm, Opmeer, B C, Kok, M., Mol, Bwj, van Baaren, G-J, CDL Klinisch Chemici in opleiding, Circulatory Health, Other research (not in main researchprogram), MS Verloskunde, Bruijn, Mmc, Vis, J Y, Wilms, F F, Oudijk, M A, Kwee, A, Porath, M M, Oei, G, Scheepers, Hcj, Spaanderman, Mea, Bloemenkamp, Kwm, Haak, M C, Bolte, A C, Vandenbussche, Fpha, Woiski, M D, Bax, C J, Cornette, Jmj, Duvekot, J J, Nij Bijvanck, Bwa, van Eyck, J, Franssen, Mtm, Sollie, K M, van der Post, Jam, Bossuyt, Pmm, Opmeer, B C, Kok, M., Mol, Bwj, and van Baaren, G-J

Published
2016

44. Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

Author

MS Verloskunde, Epi Methoden Team 1, DV&B-MT-Medisch, Brain, Circulatory Health, Child Health, Other research (not in main researchprogram), van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, Oudijk, M. A., MS Verloskunde, Epi Methoden Team 1, DV&B-MT-Medisch, Brain, Circulatory Health, Child Health, Other research (not in main researchprogram), van Vliet, E.O.G., Seinen, L., Roos, C., Schuit, E., Scheepers, H. C J, Bloemenkamp, K. W M, Duvekot, J. J., van Eyck, J., Kok, J. H., Lotgering, F. K., van Baar, A., van Wassenaer-Leemhuis, A. G., Franssen, M. T., Porath, M. M., van der Post, J. A M, Franx, A., Mol, B. W J, and Oudijk, M. A.

Published
2016

45. Quantitative fetal fibronectin testing in combination with cervical length measurement in the prediction of spontaneous preterm delivery in symptomatic women

Author

Bruijn, MMC, primary, Vis, JY, additional, Wilms, FF, additional, Oudijk, MA, additional, Kwee, A, additional, Porath, MM, additional, Oei, G, additional, Scheepers, HCJ, additional, Spaanderman, MEA, additional, Bloemenkamp, KWM, additional, Haak, MC, additional, Bolte, AC, additional, Vandenbussche, FPHA, additional, Woiski, MD, additional, Bax, CJ, additional, Cornette, JMJ, additional, Duvekot, JJ, additional, Nij Bijvanck, BWA, additional, van Eyck, J, additional, Franssen, MTM, additional, Sollie, KM, additional, van der Post, JAM, additional, Bossuyt, PMM, additional, Opmeer, BC, additional, Kok, M, additional, Mol, BWJ, additional, and van Baaren, G-J, additional

Published
2015
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46. Perinatal morbidity and mortality in early-onset fetal growth restriction:Cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

Author

Lees, C., Marlow, N., Arabin, B., Bilardo, C. M., Brezinka, C., Derks, J. B., Duvekot, J., Frusca, T., Diemert, A., Ferrazzi, E., Ganzevoort, W., Hecher, K., Martinelli, P., Ostermayer, E., Papageorghiou, A. T., Schlembach, D., Schneider, K. T.M., Thilaganathan, B., Todros, T., Van Wassenaer-Leemhuis, A., Valcamonico, A., Visser, G. H.A., Wolf, H., Scheepers, H. C.J., Spaanderman, M., Calvert, S., Missfelder-Lobos, H., Van Eyck, J., Oepkes, D., Fratelli, N., Prefumo, F., Napolitano, R., Chaoui, R., Maso, G., Ogge, G., Oberto, M., Mensing Van Charante, N., and Obstetrics and gynaecology

Abstract

Objectives: Few data exist for counseling and perinatal management of women after an antenatal diagnosis of early-onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe perinatal morbidity and mortality following early-onset fetal growth restriction based on time of antenatal diagnosis and delivery. Methods: We report cohort outcomes for a prospective multicenter randomized management study of fetal growth restriction (Trial of Randomized Umbilical and Fetal Flow in Europe (TRUFFLE)) performed in 20 European perinatal centers between 2005 and 2010. Women with a singleton fetus at 26-32 weeks of gestation, with abdominal circumference < 10th percentile and umbilical artery Doppler pulsatility index > 95th percentile, were recruited. The main outcome measure was a composite of fetal or neonatal death or severe morbidity: survival to discharge with severe brain injury, bronchopulmonary dysplasia, proven neonatal sepsis or necrotizing enterocolitis. Results: Five-hundred and three of 542 eligible women formed the study group. Mean ± SD gestational age at diagnosis was 29 ± 1.6 weeks and mean ± SD estimated fetal weight was 881 ± 217 g; 12 (2.4%) babies died in utero. Gestational age at delivery was 30.7 ± 2.3 weeks, and birth weight was 1013 ± 321 g. Overall, 81% of deliveries were indicated by fetal condition and 97% were by Cesarean section. Of 491 liveborn babies, outcomes were available for 490 amongst whom there were 27 (5.5%) deaths and 118 (24%) babies suffered severe morbidity. These babies were smaller at birth (867 ± 251 g) and born earlier (29.6 ± 2.0 weeks). Death and severe morbidity were significantly related to gestational age, both at study entry and delivery and also with the presence of maternal hypertensive morbidity. The median time to delivery was 13 days for women without hypertension, 8 days for those with gestational hypertension, 4 days for pre-eclampsia and 3 days for HELLP syndrome. Conclusions: Fetal outcome in this study was better than expected from contemporary reports: perinatal death was uncommon (8%) and 70% survived without severe neonatal morbidity. The intervals to delivery, death and severe morbidity were related to the presence and severity of maternal hypertensive conditions.

Published
2013

47. Effect of Maintenance Tocolysis With Nifedipine in Threatened Preterm Labor on Perinatal Outcomes: A Randomized Controlled Trial EDITORIAL COMMENT

Author

Roos, C., Spaanderman, M.E.A., Schuit, E., Bloemenkamp, K.W.M., Bolte, A.C., Cornette, J., Duvekot, J.J.J., van Eyck, J., Franssen, M.T.M., de Groot, C.J.M., Kok, J.H., Kwee, A., Merien, A., Bijvank, B.N., Opmeer, B.C., Oudijk, M.A., van Pampus, M.G., Papatsonis, D.N.M., Porath, M.M., Scheepers, H.C.J., Scherjon, S.A., Sollie, K.M., Vijgen, S.M.C., Willekes, C., Mol, B.J., van der Post, J.A.M., Lotgering, F.K., Other departments, Other Research, Neonatology, Clinical Research Unit, Obstetrics and Gynaecology, Amsterdam Public Health, Amsterdam Reproduction & Development (AR&D), Reproductive Origins of Adult Health and Disease (ROAHD), Obstetrics and gynaecology, and ICaR - Ischemia and repair

Published
2013

48. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

Author

Lees, C, Marlow, N, Arabin, B, Bilardo, Cm, Brezinka, C, Derks, Jb, Duvekot, J, Frusca, T, Diemert, A, Ferrazzi, E, Ganzevoort, W, Hecher, K, Martinelli, P, Ostermayer, E, Papageorghiou, At, Schlembach, D, Schneider, Kt, Thilaganathan, B, Todros, Tullia, van Wassenaer Leemhuis, A, Valcamonico, A, Visser, Gh, Wolf, H, on behalf of the TRUFFLE Group##The TRUFFLE Group collaborating authors include: Missfelder Lobos, H, van Eyck, J, Oepkes, D, Fratelli, N, Prefumo, F, Napolitano, R, Chaoui, R, Maso, G, Ogge', Giovanna, Oberto, Manuela, and van Charante NM

Subjects
Perinatal mortality, Perinatal morbidity, Fetal Growth Restriction
Published
2013

49. Predictive Value of Cervical Length Measurement and Fibronectin Testing in Threatened Preterm Labor

Author

van Baaren, G.J., primary, Vis, J.Y., additional, Wilms, F.F., additional, Oudijk, M.A., additional, Kwee, A., additional, Porath, M.M., additional, Oei, G., additional, Scheepers, H.C., additional, Spaanderman, M.E., additional, Bloemenkamp, K.W., additional, Haak, M.C., additional, Bolte, A.C., additional, Bax, C.J., additional, Cornette, J.M., additional, Duvekot, J.J., additional, Nij Bijvanck, B.W., additional, van Eyck, J., additional, Franssen, M.T., additional, Sollie, K.M., additional, Vandenbussche, F.P., additional, Woiski, M., additional, Grobman, W.A., additional, van der Post, J.A., additional, Bossuyt, P.M., additional, Opmeer, B.C., additional, and Mol, B.W., additional

Published
2015
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50. [207-POS]

Author

van Eerden, Leonoor, primary, Zeeman, G.G., additional, Christiaens, G.C.M., additional, Vandenbussche, F., additional, Oei, S.G.., additional, Scheepers, H.C.J., additional, van Eyck, J., additional, Middledorp, J.M., additional, Pajkrt, E., additional, Duvekot, J.J., additional, de Groot, C.J.M., additional, and Bolte, A.C., additional

Published
2015
Full Text
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