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2. Pulmonary perfusion defects or residual vascular obstruction and persistent symptoms after pulmonary embolism: a systematic review and meta-analysis

Author

Cimini, Ludovica Anna, primary, Luijten, Dieuwke, additional, Barco, Stefano, additional, Ghanima, Waleed, additional, Jervan, Øyvind, additional, Kahn, Susan R., additional, Konstantinides, Stavros, additional, Lachante, Daniel, additional, Nakano, Yoshihisa, additional, Ninaber, Maarten, additional, van Es, Josien, additional, van Mens, Thijs, additional, Vonk Noordegraaf, Anton, additional, Becattini, Cecilia, additional, and Klok, Frederikus A., additional

Published
2024
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4. Bronchoscopic Intrapulmonary Recombinant Factor VIIa for Diffuse Alveolar Hemorrhage-induced Acute Respiratory Failure in MPO-ANCA Vasculitis: A Case Report

Author

Smesseim Illaa, Schaepman-Ruys Titia, Duitman Jan Willem, Vegting Yosta, Raasveld Jorinde, Hilhorst Marc, Vlaar Alexander, van Es Josien, and Bonta Peter

Subjects
ards, diffuse alveolar hemorrhage, dah, novoseven, vasculitis, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Diffuse alveolar haemorrhage (DAH) is a potentially life-threatening disease, characterized by diffuse accumulation of red blood cells within the alveoli. It can be caused by a variety of disorders. In case DAH results in severe respiratory failure, veno-venous extracorporeal membrane oxygenation (VV-ECMO) can be required. Since VV-ECMO coincides with the need for anticoagulation therapy, this results in a major clinical challenge in DAH patients with hemoptysis.

Published
2022
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5. Patients with CTEPH and mild hemodynamic severity of disease improve to a similar level of exercise capacity after pulmonary endarterectomy compared to patients with severe hemodynamic disease

Author

van Kan, Coen, primary, Tramper, Jelco, additional, Bresser, Paul, additional, J. Meijboom, Lilian, additional, Symersky, Petr, additional, Winkelman, Jacobus A., additional, Nossent, Esther J., additional, Aman, Jurjan, additional, Bogaard, Harm Jan, additional, Vonk Noordegraaf, Anton, additional, and van Es, Josien, additional

Published
2024
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7. CTEPH patients with mild hemodynamic severity of disease improve to a similar level of exercise capacity after pulmonary endarterectomy compared to patients with severe hemodynamic disease.

Author

van Kan, Coen, primary, Tramper, Jelco, additional, Bresser, Paul, additional, Meijboom, Lilian, additional, Symersky, Petr, additional, Winkelman, Toon, additional, Nossent, Esther, additional, Aman, Jurjan, additional, Bogaard, Harm Jan, additional, Vonk Noordegraaf, Anton, additional, and Van Es, Josien, additional

Published
2023
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9. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study

Author

Fogteloo, Anne J, Kroft, Lucia J M, Brekelmans, Marjolein P, Vermaire, René M J, Bastiaansen-Bergsma, Hanny, Biedermann, Jossi S, Klijn, Adinda, van der Voort, Sanne, Lieveld, Arthur W E, de Jong, Peter Y, Schaar, Cees G, del Sol, Antonio Iglesias, van der Hulle, Tom, Cheung, Whitney Y, Kooij, Stephanie, Beenen, Ludo F M, van Bemmel, Thomas, van Es, Josien, Faber, Laura M, Hazelaar, Germa M, Heringhaus, Christian, Hofstee, Herman, Hovens, Marcel M C, Kaasjager, Karin A H, van Klink, Rick C J, Kruip, Marieke J H A, Loeffen, Rinske F, Mairuhu, Albert T A, Middeldorp, Saskia, Nijkeuter, Mathilde, van der Pol, Liselotte M, Schol-Gelok, Suzanne, ten Wolde, Marije, Klok, Frederikus A, and Huisman, Menno V

Published
2017
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10. Differences in incidence, nature of symptoms, and duration of long COVID among hospitalised migrant and non-migrant patients in the Netherlands:a retrospective cohort study

Author

Chilunga, Felix Patience, Appelman, Brent, van Vugt, Michele, Kalverda, Kirsten, Smeele, Patrick, van Es, Josien, Wiersinga, Willem Joost, Rostila, Mikael, Prins, Maria, Stronks, Karien, Norredam, Marie, Agyemang, Charles, Chilunga, Felix Patience, Appelman, Brent, van Vugt, Michele, Kalverda, Kirsten, Smeele, Patrick, van Es, Josien, Wiersinga, Willem Joost, Rostila, Mikael, Prins, Maria, Stronks, Karien, Norredam, Marie, and Agyemang, Charles

Abstract

Background Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, and duration of long COVID among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, and Surinamese origin, Others). Methods We used COVID-19 admissions and follow up data (January 2021–July 2022) from Amsterdam University Medical Centers. We calculated long COVID incidence proportions per NICE guidelines by migration background and assessed for clinical predictors via robust Poisson regressions. We then examined associations between migration background and long COVID using robust Poisson regressions and adjusted for derived clinical predictors, and other biologically relevant factors. We also assessed long COVID symptom persistence at one-year post-discharge. Findings 1886 patients were included. 483 patients had long COVID (26%, 95% CI 24–28%) at 12 weeks post-discharge. Symptoms like dizziness, joint pain, insomnia, and headache varied by migration background. Clinical predictors of long COVID were female sex, hospital admission duration, intensive care unit admission, and receiving oxygen, or corticosteroid therapy. Long COVID risk was higher among patients with migration background than Dutch origin patients after adjustments for derived clinical predictors, age, smoking, vaccination status, comorbidities and remdesivir treatment. Only 14% of long COVID symptoms persisted at one-year post-discharge. Interpretation There are significant differences in occurrence, nature of symptoms, and duration of long COVID by migration background. Studies assessing the spectrum of functional limitation and access to post-COVID healthcare are needed to help plan for appropriate and accessible healthcare interventions., Background: Comprehensive data on long COVID across ethnic and migrant groups are lacking. We investigated incidence, nature of symptoms, clinical predictors, and duration of long COVID among COVID-19 hospitalised patients in the Netherlands by migration background (Dutch, Turkish, Moroccan, and Surinamese origin, Others). Methods: We used COVID-19 admissions and follow up data (January 2021–July 2022) from Amsterdam University Medical Centers. We calculated long COVID incidence proportions per NICE guidelines by migration background and assessed for clinical predictors via robust Poisson regressions. We then examined associations between migration background and long COVID using robust Poisson regressions and adjusted for derived clinical predictors, and other biologically relevant factors. We also assessed long COVID symptom persistence at one-year post-discharge. Findings: 1886 patients were included. 483 patients had long COVID (26%, 95% CI 24–28%) at 12 weeks post-discharge. Symptoms like dizziness, joint pain, insomnia, and headache varied by migration background. Clinical predictors of long COVID were female sex, hospital admission duration, intensive care unit admission, and receiving oxygen, or corticosteroid therapy. Long COVID risk was higher among patients with migration background than Dutch origin patients after adjustments for derived clinical predictors, age, smoking, vaccination status, comorbidities and remdesivir treatment. Only 14% of long COVID symptoms persisted at one-year post-discharge. Interpretation: There are significant differences in occurrence, nature of symptoms, and duration of long COVID by migration background. Studies assessing the spectrum of functional limitation and access to post-COVID healthcare are needed to help plan for appropriate and accessible healthcare interventions. Funding: The Amsterdam UMC COVID-19 biobank is supported by the Amsterdam UMC Corona Research Fund and the Talud Foundation (Stichting Talud). The cur

Published
2023

14. Evolution of CT findings after anticoagulant treatment for acute pulmonary embolism in patients with and without an ultimate diagnosis of CTEPH 'Evolution of CT findings after acute PE'

Author

Braams, Natalia J., Boon, Gudula J.A.M., De Man, Frances S., Van Es, Josien, Den Exter, Paul L., Kroft, Lucia J.M., Beenen, Ludo F.M., Huisman, Menno V., Nossent, Esther J., Boonstra, Anco, Noordegraaf, Anton Vonk, Ruigrok, Dieuwertje, Klok, Frederikus A., Bogaard, Harm Jan, Meijboom, Lilian J., Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Radiology and nuclear medicine, Pulmonology, Radiology and Nuclear Medicine, ACS - Microcirculation, ANS - Neurovascular Disorders, and Graduate School

Subjects
Anticoagulant drugs, CT angiography, Pulmonary arteries, Pulmonary embolism, Pulmonary hypertension
Abstract

Introduction: The pulmonary arterial morphology of patients with pulmonary embolism (PE) is diverse and it is unclear how the different vascular lesions evolve after initiation of anticoagulant treatment. A better understanding of the evolution of CTPA findings after the start of anticoagulant treatment may help to better identify those PE patients prone to develop CTEPH. We aimed to assess the evolution of various thromboembolic lesions on CTPA over time after the initiation of adequate anticoagulant treatment in individual acute PE patients with and without an ultimate diagnosis of CTEPH. Methods: We analyzed the CTPA at diagnosis of acute PE (baseline) and at follow-up in 41 patients with CTEPH and 124 patients without an ultimate diagnosis of CTEPH, all receiving anticoagulant treatment. Central and segmental pulmonary arteries were scored by expert chest radiologists as normal or affected. Lesions were further sub-classified as: 1. central thrombus, 2. total thrombotic occlusion, 3. mural thrombus, 4. web or 5. tapered pulmonary artery. Results: Central thrombi resolved after anticoagulant treatment, while mural thrombi and total thrombotic occlusions either resolved or evolved into webs or tapered pulmonary arteries. Only patients with an ultimate diagnosis of CTEPH exhibited webs and tapered pulmonary arteries on the baseline scan. Moreover, such lesions always persisted after follow-up. Conclusion: Webs and tapered pulmonary arteries at the time of PE diagnosis strongly indicate a state of chronic PE and should raise awareness for possible CTEPH, particularly in patients with persistent dyspnea after anticoagulant treatment for acute PE.

Published
2021

17. Evolution of CT findings after anticoagulant treatment for acute pulmonary embolism in patients with and without an ultimate diagnosis of chronic thromboembolic pulmonary hypertension

Author

Braams, Natalia J., primary, Boon, Gudula J.A.M., additional, de Man, Frances S., additional, van Es, Josien, additional, den Exter, Paul L., additional, Kroft, Lucia J.M., additional, Beenen, Ludo F.M., additional, Huisman, Menno V., additional, Nossent, Esther J., additional, Boonstra, Anco, additional, Vonk Noordegraaf, Anton, additional, Ruigrok, Dieuwertje, additional, Klok, Frederikus A., additional, Bogaard, Harm Jan, additional, and Meijboom, Lilian J., additional

Published
2021
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19. Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism: The ADJUST-PE Study

Author

Righini, Marc, Van Es, Josien, Den Exter, Paul L., Roy, Pierre-Marie, Verschuren, Franck, Ghuysen, Alexandre, Rutschmann, Olivier T., Sanchez, Olivier, Jaffrelot, Morgan, Trinh-Duc, Albert, Le Gall, Catherine, Moustafa, Farès, Principe, Alessandra, Van Houten, Anja A., Ten Wolde, Marije, Douma, Renée A., Hazelaar, Germa, Erkens, Petra M. G., Van Kralingen, Klaas W., Grootenboers, Marco J. J. H., Durian, Marc F., Cheung, Whitney Y., Meyer, Guy, Bounameaux, Henri, Huisman, Menno V., Kamphuisen, Pieter W., and Le Gal, Grégoire

Published
2014
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24. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study

Author

van der Hulle, Tom, primary, Cheung, Whitney Y, additional, Kooij, Stephanie, additional, Beenen, Ludo F M, additional, van Bemmel, Thomas, additional, van Es, Josien, additional, Faber, Laura M, additional, Hazelaar, Germa M, additional, Heringhaus, Christian, additional, Hofstee, Herman, additional, Hovens, Marcel M C, additional, Kaasjager, Karin A H, additional, van Klink, Rick C J, additional, Kruip, Marieke J H A, additional, Loeffen, Rinske F, additional, Mairuhu, Albert T A, additional, Middeldorp, Saskia, additional, Nijkeuter, Mathilde, additional, van der Pol, Liselotte M, additional, Schol-Gelok, Suzanne, additional, ten Wolde, Marije, additional, Klok, Frederikus A, additional, Huisman, Menno V, additional, Fogteloo, Anne J, additional, Kroft, Lucia J M, additional, Brekelmans, Marjolein P, additional, Vermaire, René M J, additional, Bastiaansen-Bergsma, Hanny, additional, Biedermann, Jossi S, additional, Klijn, Adinda, additional, van der Voort, Sanne, additional, Lieveld, Arthur W E, additional, de Jong, Peter Y, additional, Schaar, Cees G, additional, and del Sol, Antonio Iglesias, additional

Published
2017
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25. Is a normal computed tomography pulmonary angiography safe to rule out acute pulmonary embolism in patients with a likely clinical probability?

Author

van der Hulle, Tom, additional, van Es, Nick, additional, den Exter, Paul, additional, van Es, Josien, additional, Mos, Inge, additional, Douma, Renée, additional, Kruip, Marieke, additional, Hovens, Marcel, additional, ten Wolde, Marije, additional, Nijkeuter, Mathilde, additional, ten Cate, Hugo, additional, Kamphuisen, Pieter, additional, Büller, Harry, additional, Huisman, Menno, additional, and Klok, Frederikus, additional

Published
2017
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26. Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study

Author

van der Hulle, Tom, Cheung, Whitney Y, Kooij, Stephanie, Beenen, Ludo F M, van Bemmel, Thomas, van Es, Josien, Faber, Laura M, Hazelaar, Germa M, Heringhaus, Christian, Hofstee, Herman, Hovens, Marcel M C, Kaasjager, Karin A H, van Klink, Rick C J, Kruip, Marieke J H A, Loeffen, Rinske F, Mairuhu, Albert T A, Middeldorp, Saskia, Nijkeuter, Mathilde, van der Pol, Liselotte M, Schol-Gelok, Suzanne, ten Wolde, Marije, Klok, Frederikus A, Huisman, Menno V, Fogteloo, Jaap A, Kroft, Lucia J M, Brekelmans, Marjolein P, Vermaire, René M J, Bastiaansen-Bergsma, Hanny, Biedermann, Jossi S, Klijn, Adinda, van der Voort, Sanne, Lieveld, Arthur W E, de Jong, Peter Y, Schaar, Cees G, and del Sol, Antonio Iglesias

Abstract

Validated diagnostic algorithms in patients with suspected pulmonary embolism are often not used correctly or only benefit subgroups of patients, leading to overuse of computed tomography pulmonary angiography (CTPA). The YEARS clinical decision rule that incorporates differential D-dimer cutoff values at presentation, has been developed to be fast, to be compatible with clinical practice, and to reduce the number of CTPA investigations in all age groups. We aimed to prospectively evaluate this novel and simplified diagnostic algorithm for suspected acute pulmonary embolism.

Published
2024
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27. Wells Rule andd-Dimer Testing to Rule Out Pulmonary Embolism

Author

van Es, Nick, primary, van der Hulle, Tom, additional, van Es, Josien, additional, den Exter, Paul L., additional, Douma, Renée A., additional, Goekoop, Robbert J., additional, Mos, Inge C.M., additional, Galipienzo, Javier, additional, Kamphuisen, Pieter W., additional, Huisman, Menno V., additional, Klok, Frederikus A., additional, Büller, Harry R., additional, and Bossuyt, Patrick M., additional

Published
2016
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28. Accuracy of X-ray with perfusion scan in young patients with suspected pulmonary embolism

Author

Van Es, Josien, Douma, Renée R.A., Hezemans, Rachelø E L, Penaloza, Andrea, Motte, Serge, Erkens, Petra G M, Durian, Marc M.F., Van Eck-Smit, Berthe L F, Kamphuisen, Pieter Willem, Van Es, Josien, Douma, Renée R.A., Hezemans, Rachelø E L, Penaloza, Andrea, Motte, Serge, Erkens, Petra G M, Durian, Marc M.F., Van Eck-Smit, Berthe L F, and Kamphuisen, Pieter Willem

Abstract

Background Computed tomography pulmonary angiogram (CTPA) has become the standard test in the diagnostic workup of patients with suspected pulmonary embolism (PE). However, young patients may have an increased risk of cancer with CTPA. Perfusion scanning combined with chest X-ray (X/Q) may offer an adequate alternative, but has never been prospectively validated. We directly compared this strategy with CTPA in patients aged ≤ 50 years with suspected PE. Methods Consecutive patients with a likely clinical probability or an abnormal D-dimer level underwent both CTPA and X/Q. Two trained and experienced nuclear physicians independently analyzed the X/Q-scans. The accuracy of X/Q according to the PISAPED criteria was calculated in terms of sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Results Seventy-six patients were included, with a PE rate of 33%. The inter-observer agreement for X/Q-scan reading was high (κ = 0.89). After consensus reading, 21 patients (28%) were categorized as 'PE present', 53 (70%) as 'PE absent', and two (2.6%) as 'non-diagnostic'. In 22%, there was a discrepancy between the X/Q-scan and CPTA for the diagnosis or exclusion of PE. The PPV and NPV were 71% and 83%, respectively. Conclusion In patients with a high risk of PE, a diagnostic strategy of chest X-ray and perfusion scanning using the PISAPED criteria seems less safe than CTPA. Additional studies should further investigate this diagnostic algorithm., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

30. Age-Adjusted D-Dimer Cut-off Levels to Rule out Pulmonary Embolism: A Prospective Outcome Study

Author

Righini, Marc, primary, Exter, Paul den, additional, van ES, Josien, additional, Verschuren, Franck, additional, Ghuisen, Alexandre, additional, Rutschman, Olivier, additional, Schotté, Thibault, additional, Sanchez, Olivier, additional, Jaffrelot, Morgan, additional, Karre, Meissa, additional, Peudepiece, Pascal, additional, Schmidt, Jeannot, additional, Principe, Alessandra, additional, van Houten, Anja A, additional, Wolde, Marije Ten, additional, Douma, Renée A, additional, Hazelaar, Germa, additional, Erkens, Petra MG, additional, Van Kralingen, Klaas, additional, Grootenboers, Marco, additional, Durian, Marc F, additional, Cheung, Whitney, additional, Bounameaux, Henri, additional, Huisman, Menno V., additional, Kamphuisen, Pieter W., additional, and Le Gal, Gregoire, additional

Published
2013
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32. Wells Rule and d-Dimer Testing to Rule Out Pulmonary Embolism: A Systematic Review and Individual-Patient Data Meta-analysis.

Author

van Es, Nick, van der Hulle, Tom, van Es, Josien, den Exter, Paul L., Douma, Renée A., Goekoop, Robbert J., Mos, Inge C. M., Galipienzo, Javier, Kamphuisen, Pieter W., Huisman, Menno V., Klok, Frederikus A., Büller, Harry R., and Bossuyt, Patrick M.

Subjects
FIBRIN fragment D, PULMONARY embolism, LUNG diseases, THROMBOEMBOLISM, COMPUTED tomography, ANTICOAGULANTS
Abstract

Background: The performance of different diagnostic strategies for pulmonary embolism (PE) in patient subgroups is unclear.Purpose: To evaluate and compare the efficiency and safety of the Wells rule with fixed or age-adjusted d-dimer testing overall and in inpatients and persons with cancer, chronic obstructive pulmonary disease, previous venous thromboembolism, delayed presentation, and age 75 years or older.Data Sources: MEDLINE and EMBASE from 1 January 1988 to 13 February 2016.Study Selection: 6 prospective studies in which the diagnostic management of PE was guided by the dichotomized Wells rule and quantitative d-dimer testing.Data Extraction: Individual data of 7268 patients; risk of bias assessed by 2 investigators with the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool.Data Synthesis: The proportion of patients in whom imaging could be withheld based on a "PE-unlikely" Wells score and a negative d-dimer test result (efficiency) was estimated using fixed (≤500 µg/L) and age-adjusted (age × 10 µg/L in patients aged >50 years) d-dimer thresholds; their 3-month incidence of symptomatic venous thromboembolism (failure rate) was also estimated. Overall, efficiency increased from 28% to 33% when the age-adjusted (instead of the fixed) d-dimer threshold was applied. This increase was more prominent in elderly patients (12%) but less so in inpatients (2.6%). The failure rate of age-adjusted d-dimer testing was less than 3% in all examined subgroups.Limitation: Post hoc analysis, between-study differences in patient characteristics, use of various d-dimer assays, and limited statistical power to assess failure rate.Conclusion: Age-adjusted d-dimer testing is associated with a 5% absolute increase in the proportion of patients with suspected PE in whom imaging can be safely withheld compared with fixed d-dimer testing. This strategy seems safe across different high-risk subgroups, but its efficiency varies.Primary Funding Source: None. [ABSTRACT FROM AUTHOR]

Published
2016
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33. The combination of four different clinical decision rules and an age-adjusted D-dimer cut-off increases the number of patients in whom acute pulmonary embolism can safely be excluded

Author

Mos, Inge, primary, Douma, Renée, primary, Erkens, Petra, primary, Durian, Marc, primary, Nizet, Tessa, primary, van Houten, Anja, primary, Hofstee, Herman, primary, ten Cate, Hugo, primary, Ullmann, Eric, primary, Büller, Harry, primary, Huisman, Menno, primary, Kamphuisen, P. W., primary, and van Es, Josien, additional

Published
2012
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40. Performance of the revised Geneva score in patients with a delayed suspicion of pulmonary embolism.

Author

den Exter PL, van den Hoven P, van der Hulle T, Mos IC, Douma RA, van Es J, Huisman MV, and Klok FA

Subjects
Acute Disease, Adult, Aged, Algorithms, Decision Support Techniques, Female, Fibrin Fibrinogen Degradation Products biosynthesis, Humans, Male, Middle Aged, Probability, Prospective Studies, Pulmonary Embolism blood, Reproducibility of Results, Sensitivity and Specificity, Pulmonary Embolism diagnosis, Severity of Illness Index
Published
2014
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