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24 results on '"van Dooremalen, Sanne"'

1. Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity

Author

Hiemstra, Ida H., Santegoets, Kim C.M., Janmaat, Maarten L., De Goeij, Bart E.C.G., Ten Hagen, Wessel, van Dooremalen, Sanne, Boross, Peter, van den Brakel, Jeroen, Bosgra, Sieto, Andringa, Grietje, van Kessel-Welmers, Berris, Verzijl, Dennis, Hibbert, Richard G., Frerichs, Kristine A., Mutis, Tuna, van de Donk, Niels W.C.J., Ahmadi, Tahamtan, Satijn, David, Sasser, A. Kate, and Breij, Esther C.W.

Published
2023
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2. Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells

Author

Kierkels, Guido J.J., van Diest, Eline, Hernández-López, Patricia, Scheper, Wouter, de Bruin, Anja C.M., Frijlink, Elselien, Aarts-Riemens, Tineke, van Dooremalen, Sanne F.J., Beringer, Dennis X., Oostvogels, Rimke, Kramer, Lovro, Straetemans, Trudy, Uckert, Wolfgang, Sebestyén, Zsolt, and Kuball, Jürgen

Published
2021
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3. Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

Author

van der Wagen, Lotte E., Miranda-Bedate, Alberto, Janssen, Anke, Fernando, Febilla, Appukudige, Nagesha, van Dooremalen, Sanne, Westinga, Kasper, Admiraal, Rick, Lorenowicz, Magdalena J., Huls, Gerwin, Janssen, Jeroen J. W. M., Broers, Annoek E. C., van der Velden, Walter J. F. M., van Marwijk Kooy, Rien, Hazenberg, Mette D., de Haar, Colin, Lindemans, Caroline, Jan Boelens, Jaap, and Kuball, Jürgen

Published
2020
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Author

CTI Kuball, Unit Opleiding Aios, Infection & Immunity, Cancer, CTI Beringer, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Vyborova, Anna, Janssen, Anke, Gatti, Lucrezia, Karaiskaki, Froso, Yonika, Austin, van Dooremalen, Sanne, Sanders, Jasper, Beringer, Dennis X, Straetemans, Trudy, Sebestyen, Zsolt, Kuball, Jürgen, CTI Kuball, Unit Opleiding Aios, Infection & Immunity, Cancer, CTI Beringer, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Vyborova, Anna, Janssen, Anke, Gatti, Lucrezia, Karaiskaki, Froso, Yonika, Austin, van Dooremalen, Sanne, Sanders, Jasper, Beringer, Dennis X, Straetemans, Trudy, Sebestyen, Zsolt, and Kuball, Jürgen

Published
2022

7. Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Author

van Diest, Eline, primary, Hernández López, Patricia, additional, Meringa, Angelo D, additional, Vyborova, Anna, additional, Karaiskaki, Froso, additional, Heijhuurs, Sabine, additional, Gumathi Bormin, Jan, additional, van Dooremalen, Sanne, additional, Nicolasen, Mara J T, additional, Gatti, Lucrezia C D E, additional, Johanna, Inez, additional, Straetemans, Trudy, additional, Sebestyén, Zsolt, additional, Beringer, Dennis X, additional, and Kuball, Jürgen, additional

Published
2021
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8. γδ T-cell Receptors Derived from Breast Cancer–Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Author

Janssen, Anke, Villacorta Hidalgo, Jose, Beringer, Dennis X, Van Dooremalen, Sanne, Febilla, Fernando, Van Diest, Eline, Terrizzi, Antonela Romina, Bronser, Peter, Kock, Sylvia, Schmitt-Gräff, Annette, Werner, Martin, Fisch, Paul, Heise, Kerstin, Follo, Marie, Straetemans, Trudy, Sebestyen, Zsolt, Chudakov, Dmitry M, Kasatskaya, Sofya A., Kuball, Jurgen, Frenkel, Felix E., Ravens, Sarina, Spierings, Eric, Prinz, Immo, Malkovsky, Miroslav, Küppers, Ralf, Graduate School, and Amsterdam Reproduction & Development (AR&D)

Subjects
0301 basic medicine, Adult, Cancer Research, CIENCIAS MÉDICAS Y DE LA SALUD, T cell, medicine.medical_treatment, Immunology, Medizin, Inmunología, chemical and pharmacologic phenomena, Triple Negative Breast Neoplasms, Biology, Immunotherapy, Adoptive, GAMMA DELTA LYMPHOCYTES, 03 medical and health sciences, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, Antigen, T-Lymphocyte Subsets, BREAST CANCER, Cell Line, Tumor, medicine, Humans, Receptor, Aged, Aged, 80 and over, Innate immune system, T-cell receptor, High-Throughput Nucleotide Sequencing, hemic and immune systems, Receptors, Antigen, T-Cell, gamma-delta, Immunotherapy, Middle Aged, Coculture Techniques, Healthy Volunteers, Medicina Básica, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Case-Control Studies, Cancer cell, Cancer research, Leukocytes, Mononuclear, Female
Abstract

γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCRs) from tumor-infiltrating γδ T lymphocytes (γδ TILs) that were in direct contact with tumor cells in breast cancer lesions from archival material. We observed that the majority of γδ TILs harbored a proinflammatory phenotype and only a minority associated with the expression of IL17. We characterized TCRγ or TCRδ chains of γδ TILs and observed a higher proportion of Vδ2+ T cells compared to other tumor types. By reconstructing matched Vδ2- TCRγ and TCRδ pairs derived from single-cell sequencing, our data suggest that γδ TILs could be active against breast cancer and other tumor types. The reactivity pattern against tumor cells depended on both the TCRγ and TCRδ chains and was independent of additional co-stimulation through other innate immune receptors. We conclude that γδ TILs can mediate tumor reactivity through their individual γδ TCR pairs and that engineered T cells expressing TCRγ and δ chains derived from γδ TILs display potent antitumor reactivity against different cancer cell types and, thus, may be a valuable tool for engineering immune cells for adoptive cell therapies. Fil: Janssen, Anke. University of Utrecht; Países Bajos Fil: Villacorta Hidalgo, Jose. Albert Ludwigs University of Freiburg; Alemania Fil: Beringer, Dennis X. University of Utrecht; Países Bajos Fil: Van Dooremalen, Sanne. University of Utrecht; Países Bajos Fil: Febilla, Fernando. Utrecht University, Netherlands; Argentina Fil: Van Diest, Eline. Utrecht University, Netherlands; Argentina Fil: Terrizzi, Antonela Romina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Fisiología; Argentina Fil: Bronser, Peter. Albert Ludwigs University of Freiburg; Alemania Fil: Kock, Sylvia. Albert Ludwigs University of Freiburg; Alemania Fil: Schmitt-Gräff, Annette. Albert Ludwigs University of Freiburg; Alemania Fil: Werner, Martin. Albert Ludwigs University of Freiburg; Alemania Fil: Fisch, Paul. Albert Ludwigs University of Freiburg; Alemania Fil: Heise, Kerstin. University of Duisburg-Essen; Alemania Fil: Follo, Marie. Albert Ludwigs University of Freiburg; Alemania Fil: Straetemans, Trudy. University of Utrecht; Países Bajos Fil: Sebestyen, Zsolt. University of Utrecht; Países Bajos Fil: Chudakov, Dmitry M. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry; Rusia Fil: Kasatskaya, Sofya A.. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry; Rusia Fil: Kuball, Jurgen. University of Utrecht; Países Bajos Fil: Frenkel, Felix E.. No especifíca; Fil: Ravens, Sarina. Hannover Medical School; Alemania Fil: Spierings, Eric. University of Utrecht; Países Bajos Fil: Prinz, Immo. Hannover Medical School; Alemania Fil: Malkovsky, Miroslav. UW School of Medicine and Public Health; Estados Unidos Fil: Fisch, Paul. Albert Ludwigs University of Freiburg; Alemania Fil: Küppers, Ralf. University of Duisburg-Essen; Alemania

Published
2020

9. Gamma delta TCR anti-CD3 bispecific molecules (GABs) as novel immunotherapeutic compounds

Author

CTI Kuball, Infection & Immunity, Cancer, CTI Sebestyen, Poli Van Creveldkliniek Medisch, CTI Beringer, Hematologie ICAT, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Van Diest, Eline, Hernández López, Patricia, Meringa, Angelo D., Vyborova, Anna, Karaiskaki, Froso, Heijhuurs, Sabine, Gumathi Bormin, Jan, Van Dooremalen, Sanne, Nicolasen, Mara J.T., Gatti, Lucrezia C.D.E., Johanna, Inez, Straetemans, Trudy, Sebestyén, Zsolt, Beringer, Dennis X., Kuball, Jürgen, CTI Kuball, Infection & Immunity, Cancer, CTI Sebestyen, Poli Van Creveldkliniek Medisch, CTI Beringer, Hematologie ICAT, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Van Diest, Eline, Hernández López, Patricia, Meringa, Angelo D., Vyborova, Anna, Karaiskaki, Froso, Heijhuurs, Sabine, Gumathi Bormin, Jan, Van Dooremalen, Sanne, Nicolasen, Mara J.T., Gatti, Lucrezia C.D.E., Johanna, Inez, Straetemans, Trudy, Sebestyén, Zsolt, Beringer, Dennis X., and Kuball, Jürgen

Published
2021

10. Characterization and modulation of anti-alpha beta TCR antibodies and their respective binding sites at the beta TCR chain to enrich engineered T cells

Author

CTI Kuball, Infection & Immunity, Cancer, ZL Neuro-Oncologie Medisch, CTI Beringer, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Kierkels, Guido J J, van Diest, Eline, Hernández-López, Patricia, Scheper, Wouter, de Bruin, Anja C M, Frijlink, Elselien, Aarts-Riemens, Tineke, van Dooremalen, Sanne F J, Beringer, Dennis X, Oostvogels, Rimke, Kramer, Lovro, Straetemans, Trudy, Uckert, Wolfgang, Sebestyén, Zsolt, Kuball, Jürgen, CTI Kuball, Infection & Immunity, Cancer, ZL Neuro-Oncologie Medisch, CTI Beringer, CTI Straetemans, MS Hematologie, Regenerative Medicine and Stem Cells, Kierkels, Guido J J, van Diest, Eline, Hernández-López, Patricia, Scheper, Wouter, de Bruin, Anja C M, Frijlink, Elselien, Aarts-Riemens, Tineke, van Dooremalen, Sanne F J, Beringer, Dennis X, Oostvogels, Rimke, Kramer, Lovro, Straetemans, Trudy, Uckert, Wolfgang, Sebestyén, Zsolt, and Kuball, Jürgen

Published
2021

12. Preclinical Anti-Tumor Activity of Hexabody-CD38 in Patient-Derived B Cell Lymphoma and Acute Myeloid Leukemia Xenograft Models

Author

Hiemstra, Ida H, primary, Janmaat, Maarten L, additional, Boross, Peter, additional, van den Brakel, Jeroen, additional, ten Hagen, Wessel, additional, van Dooremalen, Sanne, additional, Bosgra, Sieto, additional, De Goeij, Bart ECG, additional, Andringa, Grietje, additional, Kil, Laurens, additional, Sasser, A Kate, additional, Ahmadi, Tahamtan, additional, Satijn, David, additional, and Breij, Esther CW, additional

Published
2020
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13. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Author

Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, Kuball, Jürgen, Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, and Kuball, Jürgen

Published
2020

14. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Author

Pathobiologie, dPB RMSC, Dep Biomolecular Health Sciences, Sub Crystal and Structural Chemistry, Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, Kuball, Jürgen, Pathobiologie, dPB RMSC, Dep Biomolecular Health Sciences, Sub Crystal and Structural Chemistry, Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, and Kuball, Jürgen

Published
2020

15. Efficacy of MSC for steroid-refractory acute GVHD associates with MSC donor age and a defined molecular profile

Author

MS Hematologie, Cancer, CTI Kuball, Infection & Immunity, Unit Opleiding Aios, Apotheek Celtherapie Faciliteit, Arts-assistenten Kinderen, CMM Groep Coffer, Regenerative Medicine and Stem Cells, SCT patientenzorg, van der Wagen, Lotte E, Miranda-Bedate, Alberto, Janssen, Anke, Fernando, Febilla, Appukudige, Nagesha, van Dooremalen, Sanne F.J., Westinga, Kasper, Admiraal, Rick, Lorenowicz, Magdalena J, Huls, Gerwin, Janssen, Jeroen J W M, Broers, Annoek E C, van der Velden, Walter J F M, van Marwijk Kooy, Rien, Hazenberg, Mette D, de Haar, Colin, Lindemans, Caroline, Jan Boelens, Jaap, Kuball, Jürgen, MS Hematologie, Cancer, CTI Kuball, Infection & Immunity, Unit Opleiding Aios, Apotheek Celtherapie Faciliteit, Arts-assistenten Kinderen, CMM Groep Coffer, Regenerative Medicine and Stem Cells, SCT patientenzorg, van der Wagen, Lotte E, Miranda-Bedate, Alberto, Janssen, Anke, Fernando, Febilla, Appukudige, Nagesha, van Dooremalen, Sanne F.J., Westinga, Kasper, Admiraal, Rick, Lorenowicz, Magdalena J, Huls, Gerwin, Janssen, Jeroen J W M, Broers, Annoek E C, van der Velden, Walter J F M, van Marwijk Kooy, Rien, Hazenberg, Mette D, de Haar, Colin, Lindemans, Caroline, Jan Boelens, Jaap, and Kuball, Jürgen

Published
2020

16. gamma delta T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity

Author

Unit Opleiding Aios, CTI Kuball, CTI Sebestyen, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, UMC Utrecht, MS Hematologie, Janssen, Anke, Villacorta Hidalgo, José, Beringer, Dennis X, van Dooremalen, Sanne F.J., Fernando, Febilla, van Diest, Eline, Terrizzi, Antonela R, Bronsert, Peter, Kock, Sylvia, Schmitt-Graeff, Annette, Werner, Martin, Heise, Kerstin, Follo, Marie, Straetemans, Trudy, Sebestyen, Zsolt, Chudakov, Dmitriy M, Kasatskaya, Sofya A, Frenkel, Felix E, Ravens, Sarina, Spierings, Eric, Prinz, Immo, Küppers, Ralf, Malkovsky, Miroslav, Fisch, Paul, Kuball, Jurgen, Unit Opleiding Aios, CTI Kuball, CTI Sebestyen, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, UMC Utrecht, MS Hematologie, Janssen, Anke, Villacorta Hidalgo, José, Beringer, Dennis X, van Dooremalen, Sanne F.J., Fernando, Febilla, van Diest, Eline, Terrizzi, Antonela R, Bronsert, Peter, Kock, Sylvia, Schmitt-Graeff, Annette, Werner, Martin, Heise, Kerstin, Follo, Marie, Straetemans, Trudy, Sebestyen, Zsolt, Chudakov, Dmitriy M, Kasatskaya, Sofya A, Frenkel, Felix E, Ravens, Sarina, Spierings, Eric, Prinz, Immo, Küppers, Ralf, Malkovsky, Miroslav, Fisch, Paul, and Kuball, Jurgen

Published
2020

17. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Author

CTI Kuball, CTI Sebestyen, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Hematologie, UMC Utrecht, Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, Kuball, Jürgen, CTI Kuball, CTI Sebestyen, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, MS Hematologie, UMC Utrecht, Johanna, Inez, Hernández-López, Patricia, Heijhuurs, Sabine, Bongiovanni, Laura, de Bruin, Alain, Beringer, Dennis, van Dooremalen, Sanne, Shultz, Leonard D, Ishikawa, Fumihiko, Sebestyen, Zsolt, Straetemans, Trudy, and Kuball, Jürgen

Published
2020

18. TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice

Author

Johanna, Inez, primary, Hernández-López, Patricia, additional, Heijhuurs, Sabine, additional, Bongiovanni, Laura, additional, de Bruin, Alain, additional, Beringer, Dennis, additional, van Dooremalen, Sanne, additional, Shultz, Leonard D., additional, Ishikawa, Fumihiko, additional, Sebestyen, Zsolt, additional, Straetemans, Trudy, additional, and Kuball, Jürgen, additional

Published
2020
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20. Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro

Author

Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, CMM, CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Immunologie onderzoek 2, CMM Sectie Stem Cells, Child Health, Infection & Immunity, CMM Groep Coffer, Vonk, Lucienne A., van Dooremalen, Sanne F.J., Liv, Nalan, Klumperman, Judith, Coffer, Paul J., Saris, Daniël B.F., Lorenowicz, Magdalena J., Orthopaedie Opleiding, Regenerative Medicine and Stem Cells, CMM, CMM Groep Klumperman, Cancer, CMM Sectie Celbiologie, Brain, Immunologie onderzoek 2, CMM Sectie Stem Cells, Child Health, Infection & Immunity, CMM Groep Coffer, Vonk, Lucienne A., van Dooremalen, Sanne F.J., Liv, Nalan, Klumperman, Judith, Coffer, Paul J., Saris, Daniël B.F., and Lorenowicz, Magdalena J.

Published
2018

22. Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations

Author

CDL Contact activatie, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, CDL Staf Research, de Maat, Steven, Björkqvist, Jenny, Suffritti, Chiara, Wiesenekker, Chantal P., Nagtegaal, Willem, Koekman, Arnold, van Dooremalen, Sanne, Pasterkamp, Gerard, de Groot, Philip G., Cicardi, Marco, Renné, Thomas, Maas, Coen, CDL Contact activatie, Centraal Diagnostisch Laboratorium, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Cluster Onderzoek en Onderwijs, CDL Staf Research, de Maat, Steven, Björkqvist, Jenny, Suffritti, Chiara, Wiesenekker, Chantal P., Nagtegaal, Willem, Koekman, Arnold, van Dooremalen, Sanne, Pasterkamp, Gerard, de Groot, Philip G., Cicardi, Marco, Renné, Thomas, and Maas, Coen

Published
2016

24. γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.

Author

Janssen A, Villacorta Hidalgo J, Beringer DX, van Dooremalen S, Fernando F, van Diest E, Terrizi AR, Bronsert P, Kock S, Schmitt-Gräff A, Werner M, Heise K, Follo M, Straetemans T, Sebestyen Z, Chudakov DM, Kasatskaya SA, Frenkel FE, Ravens S, Spierings E, Prinz I, Küppers R, Malkovsky M, Fisch P, and Kuball J

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Cell Line, Tumor, Coculture Techniques, Female, Healthy Volunteers, High-Throughput Nucleotide Sequencing methods, Humans, Middle Aged, Receptors, Antigen, T-Cell, gamma-delta genetics, Triple Negative Breast Neoplasms genetics, Triple Negative Breast Neoplasms pathology, Triple Negative Breast Neoplasms therapy, Immunotherapy, Adoptive methods, Leukocytes, Mononuclear immunology, Lymphocytes, Tumor-Infiltrating immunology, Receptors, Antigen, T-Cell, gamma-delta immunology, T-Lymphocyte Subsets immunology, Triple Negative Breast Neoplasms immunology
Abstract

γδ T cells in human solid tumors remain poorly defined. Here, we describe molecular and functional analyses of T-cell receptors (TCR) from tumor-infiltrating γδ T lymphocytes (γδ TIL) that were in direct contact with tumor cells in breast cancer lesions from archival material. We observed that the majority of γδ TILs harbored a proinflammatory phenotype and only a minority associated with the expression of IL17. We characterized TCRγ or TCRδ chains of γδ TILs and observed a higher proportion of Vδ2 + T cells compared with other tumor types. By reconstructing matched Vδ2 - TCRγ and TCRδ pairs derived from single-cell sequencing, our data suggest that γδ TILs could be active against breast cancer and other tumor types. The reactivity pattern against tumor cells depended on both the TCRγ and TCRδ chains and was independent of additional costimulation through other innate immune receptors. We conclude that γδ TILs can mediate tumor reactivity through their individual γδ TCR pairs and that engineered T cells expressing TCRγ and δ chains derived from γδ TILs display potent antitumor reactivity against different cancer cell types and, thus, may be a valuable tool for engineering immune cells for adoptive cell therapies., (©2020 American Association for Cancer Research.)

Published
2020
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