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1. Immunodeficiëntie

Author

de Vries, E., van Dongen, J. J. M., Driessen, G. J. A., Derksen-Lubsen, G., editor, Moll, H.A., editor, Oudesluys-Murphy, A.M., editor, Sprij, A.J., editor, Bolt-Wieringa, J.W., editor, van den Elzen, A.P.M., editor, Leeuwenburgh-Pronk, W.G., editor, Ropers, F.G., editor, and Verhoeven, J.J., editor

Published
2018
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3. Automated EuroFlow approach for standardized in-depth dissection of human circulating B-cells and plasma cells

Author

Delgado, Alejandro H., primary, Fluxa, Rafael, additional, Perez-Andres, Martin, additional, Diks, Annieck M., additional, van Gaans-van den Brink, Jacqueline A. M., additional, Barkoff, Alex-Mikael, additional, Blanco, Elena, additional, Torres-Valle, Alba, additional, Berkowska, Magdalena A., additional, Grigore, Georgiana, additional, van Dongen, J .J .M., additional, and Orfao, Alberto, additional

Published
2023
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6. Minimal residual disease assessment in B-cell precursor acute lymphoblastic leukemia by semi-automated identification of normal hematopoietic cells: A EuroFlow study

Author

Verbeek, M, Rodríguez, B, Sedek, L, Laqua, A, Buracchi, C, Buysse, M, Reiterová, M, Oliveira, E, Morf, D, Oude Alink, S, Barrena, S, Kohlscheen, S, Nierkens, S, Hofmans, M, Fernandez, P, de Costa, E, Mejstrikova, E, Szczepanski, T, Slota, L, Brüggemann, M, Gaipa, G, Grigore, G, van Dongen, J, Orfao, A, van der Velden, V, Verbeek M. W. C., Rodríguez B. S., Sedek L., Laqua A., Buracchi C., Buysse M., Reiterová M., Oliveira E., Morf D., Oude Alink S. R., Barrena S., Kohlscheen S., Nierkens S., Hofmans M., Fernandez P., de Costa E. S., Mejstrikova E., Szczepanski T., Slota L., Brüggemann M., Gaipa G., Grigore G., van Dongen J. J. M., Orfao A., van der Velden V. H. J., Verbeek, M, Rodríguez, B, Sedek, L, Laqua, A, Buracchi, C, Buysse, M, Reiterová, M, Oliveira, E, Morf, D, Oude Alink, S, Barrena, S, Kohlscheen, S, Nierkens, S, Hofmans, M, Fernandez, P, de Costa, E, Mejstrikova, E, Szczepanski, T, Slota, L, Brüggemann, M, Gaipa, G, Grigore, G, van Dongen, J, Orfao, A, van der Velden, V, Verbeek M. W. C., Rodríguez B. S., Sedek L., Laqua A., Buracchi C., Buysse M., Reiterová M., Oliveira E., Morf D., Oude Alink S. R., Barrena S., Kohlscheen S., Nierkens S., Hofmans M., Fernandez P., de Costa E. S., Mejstrikova E., Szczepanski T., Slota L., Brüggemann M., Gaipa G., Grigore G., van Dongen J. J. M., Orfao A., and van der Velden V. H. J.

Abstract

Presence of minimal residual disease (MRD), detected by flow cytometry, is an important prognostic biomarker in the management of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, data-analysis remains mainly expert-dependent. In this study, we designed and validated an Automated Gating & Identification (AGI) tool for MRD analysis in BCP-ALL patients using the two tubes of the EuroFlow 8-color MRD panel. The accuracy, repeatability, and reproducibility of the AGI tool was validated in a multicenter study using bone marrow follow-up samples from 174 BCP-ALL patients, stained with the EuroFlow BCP-ALL MRD panel. In these patients, MRD was assessed both by manual analysis and by AGI tool supported analysis. Comparison of MRD levels obtained between both approaches showed a concordance rate of 83%, with comparable concordances between MRD tubes (tube 1, 2 or both), treatment received (chemotherapy versus targeted therapy) and flow cytometers (FACSCanto versus FACSLyric). After review of discordant cases by additional experts, the concordance increased to 97%. Furthermore, the AGI tool showed excellent intra-expert concordance (100%) and good inter-expert concordance (90%). In addition to MRD levels, also percentages of normal cell populations showed excellent concordance between manual and AGI tool analysis. We conclude that the AGI tool may facilitate MRD analysis using the EuroFlow BCP-ALL MRD protocol and will contribute to a more standardized and objective MRD assessment. However, appropriate training is required for the correct analysis of MRD data.

Published
2023

9. Differentiation stage of myeloma plasma cells: biological and clinical significance

Author

Paiva, B, Puig, N, Cedena, M T, de Jong, B G, Ruiz, Y, Rapado, I, Martinez-Lopez, J, Cordon, L, Alignani, D, Delgado, J A, van Zelm, M C, Van Dongen, J J M, Pascual, M, Agirre, X, Prosper, F, Martín-Subero, J I, Vidriales, M-B, Gutierrez, N C, Hernandez, M T, Oriol, A, Echeveste, M A, Gonzalez, Y, Johnson, S K, Epstein, J, Barlogie, B, Morgan, G J, Orfao, A, Blade, J, Mateos, M V, Lahuerta, J J, and San-Miguel, J F

Published
2017
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10. Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

Author

Pfeifer, H., Cazzaniga, G., van der Velden, V. H. J., Cayuela, J. M., Schäfer, B., Spinelli, O., Akiki, S., Avigad, S., Bendit, I., Borg, K., Cavé, H., Elia, L., Reshmi, S. C., Gerrard, G., Hayette, S., Hermanson, M., Juh, A., Jurcek, T., Chillón, M. C., Homburg, C., Martinelli, G., Kairisto, V., Lange, T., Lion, T., Mueller, M. C., Pane, F., Rai, L., Damm-Welk, C., Sacha, T., Schnittger, S., Touloumenidou, T., Valerhaugen, H., Vandenberghe, P., Zuna, J., Serve, H., Herrmann, E., Markovic, S., van Dongen, J. J. M., and Ottmann, O. G.

Published
2020
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11. Next generation flow for minimally-invasive blood characterization of MGUS and multiple myeloma at diagnosis based on circulating tumor plasma cells (CTPC)

Author

Sanoja-Flores, L., Flores-Montero, J., Garcés, J. J., Paiva, B., Puig, N., García-Mateo, A., García-Sánchez, O., Corral-Mateos, A., Burgos, L., Blanco, E., Hernández-Martín, J., Pontes, R., Díez-Campelo, M., Millacoy, P., Rodríguez-Otero, P., Prosper, F., Merino, J., Vidriales, M. B., García-Sanz, R., Romero, A., Palomera, L., Ríos-Tamayo, R., Pérez-Andrés, M., Blanco, J. F., González, M., van Dongen, J. J. M., Durie, B., Mateos, M. V., San-Miguel, J., Orfao, A., and on behalf of the EuroFlow consortium

Published
2018
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14. POS0185 BELIMUMAB DISRUPTS MEMORY B-CELL TRAFFICKING IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Author

Arends, E. J., primary, Zlei, M., additional, Tipton, C. M., additional, Cotic, J., additional, Osmani, Z., additional, de Bie, F., additional, Kamerling, S., additional, van Maurik, A., additional, Dimelow, R., additional, Gregan, Y. I., additional, Fox, N. L., additional, Rabelink, T., additional, Roth, D., additional, Sanz, I., additional, van Dongen, J. J. M., additional, van Kooten, C., additional, and Teng, Y. K. O., additional

Published
2022
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15. Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias

Author

Szczepański, T., Pongers-Willemse, M. J., Langerak, A. W., van Dongen, J. J. M., Compans, R. W., editor, Cooper, M., editor, Hogle, J. M., editor, Koprowski, H., editor, Ito, Y., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Melchers, Fritz, editor, and Potter, Michael, editor

Published
1999
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17. Flow cytometric minimal residual disease assessment in B-cell precursor acute lymphoblastic leukaemia patients treated with CD19-targeted therapies — a EuroFlow study

Author

Verbeek, M. W. C., Buracchi, C., Laqua, A., Nierkens, S., Sedek, L., Flores-Montero, J., Hofmans, M., Sobral de Costa, E., Nováková, M., Mejstrikova, E., Barrena, S., Kohlscheen, S., Szczepanowski, M., Kulis, J., Oliveira, E., Jugooa, R., de Jong, A. X., Szczepanski, T., Philippé, J., van Dongen, J. J. M., Orfao, A., Brüggemann, M., Gaipa, G., van der Velden, V. H. J., Verbeek, M. W. C., Buracchi, C., Laqua, A., Nierkens, S., Sedek, L., Flores-Montero, J., Hofmans, M., Sobral de Costa, E., Nováková, M., Mejstrikova, E., Barrena, S., Kohlscheen, S., Szczepanowski, M., Kulis, J., Oliveira, E., Jugooa, R., de Jong, A. X., Szczepanski, T., Philippé, J., van Dongen, J. J. M., Orfao, A., Brüggemann, M., Gaipa, G., and van der Velden, V. H. J.

Abstract

The standardized EuroFlow protocol, including CD19 as primary B-cell marker, enables highly sensitive and reliable minimal residual disease (MRD) assessment in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated with chemotherapy. We developed and validated an alternative gating strategy allowing reliable MRD analysis in BCP-ALL patients treated with CD19-targeting therapies. Concordant data were obtained in 92% of targeted therapy patients who remained CD19-positive, whereas this was 81% in patients that became (partially) CD19-negative. Nevertheless, in both groups median MRD values showed excellent correlation with the original MRD data, indicating that, despite higher interlaboratory variation, the overall MRD analysis was correct.

Published
2022

18. Impact of Pre-Analytical and Analytical Variables Associated with Sample Preparation on Flow Cytometric Stainings Obtained with EuroFlow Panels

Author

Sedek, L, Flores-Montero, J, van der Sluijs, A, Kulis, J, Marvelde, J, Philippe, J, Bottcher, S, Bitter, M, Caetano, J, van der Velden, V, Sonneveld, E, Buracchi, C, Santos, A, Lima, M, Szczepanski, T, van Dongen, J, Orfao, A, Sedek L., Flores-Montero J., van der Sluijs A., Kulis J., Marvelde J. T., Philippe J., Bottcher S., Bitter M., Caetano J., van der Velden V. H. J., Sonneveld E., Buracchi C., Santos A. H., Lima M., Szczepanski T., van Dongen J. J. M., Orfao A., Sedek, L, Flores-Montero, J, van der Sluijs, A, Kulis, J, Marvelde, J, Philippe, J, Bottcher, S, Bitter, M, Caetano, J, van der Velden, V, Sonneveld, E, Buracchi, C, Santos, A, Lima, M, Szczepanski, T, van Dongen, J, Orfao, A, Sedek L., Flores-Montero J., van der Sluijs A., Kulis J., Marvelde J. T., Philippe J., Bottcher S., Bitter M., Caetano J., van der Velden V. H. J., Sonneveld E., Buracchi C., Santos A. H., Lima M., Szczepanski T., van Dongen J. J. M., and Orfao A.

Abstract

Objective interpretation of FC results may still be hampered by limited technical stan-dardization. The EuroFlow consortium conducted a series of experiments to determine the impact of different variables on the relative distribution and the median fluorescence intensity (MFI) of markers stained on different cell populations, from both healthy donors and patients’ samples with distinct hematological malignancies. The use of different anticoagulants; the time interval between sample collection, preparation, and acquisition; pH of washing buffers; and the use of cell surface membrane-only (SM) vs. cell surface plus intracytoplasmic (SM+CY) staining protocols, were evaluated. Our results showed that only monocytes were represented at higher percentages in EDTA-vs. heparin-anticoagulated samples. Application of SM or SM+CY protocols resulted in slight differences in the percentage of neutrophils and debris determined only with particular antibody combinations. In turn, storage of samples for 24 h at RT was associated with greater percentage of debris and cell doublets when the plasma cell disorder panel was used. Furthermore, 24 h storage of stained cells at RT was selectively detrimental for MFI levels of CD19 and CD45 on mature B-and T-cells (but not on leukemic blasts, clonal B-and plasma cells, neutrophils, and NK cells). The obtained results showed that the variables evaluated might need to be tailored for sample and cell type(s) as well as to the specific markers compared; however, defining of well-balanced boundaries for storage time, staining-to-acquisition delay, and pH of washing buffer would be a valid recommendation for most applications and circumstances described herein.

Published
2022

19. Flow cytometric minimal residual disease assessment in B-cell precursor acute lymphoblastic leukaemia patients treated with CD19-targeted therapies — a EuroFlow study

Author

Verbeek, M, Buracchi, C, Laqua, A, Nierkens, S, Sedek, L, Flores-Montero, J, Hofmans, M, Sobral de Costa, E, Novakova, M, Mejstrikova, E, Barrena, S, Kohlscheen, S, Szczepanowski, M, Kulis, J, Oliveira, E, Jugooa, R, de Jong, A, Szczepanski, T, Philippe, J, van Dongen, J, Orfao, A, Bruggemann, M, Gaipa, G, van der Velden, V, Verbeek M. W. C., Buracchi C., Laqua A., Nierkens S., Sedek L., Flores-Montero J., Hofmans M., Sobral de Costa E., Novakova M., Mejstrikova E., Barrena S., Kohlscheen S., Szczepanowski M., Kulis J., Oliveira E., Jugooa R., de Jong A. X., Szczepanski T., Philippe J., van Dongen J. J. M., Orfao A., Bruggemann M., Gaipa G., van der Velden V. H. J., Verbeek, M, Buracchi, C, Laqua, A, Nierkens, S, Sedek, L, Flores-Montero, J, Hofmans, M, Sobral de Costa, E, Novakova, M, Mejstrikova, E, Barrena, S, Kohlscheen, S, Szczepanowski, M, Kulis, J, Oliveira, E, Jugooa, R, de Jong, A, Szczepanski, T, Philippe, J, van Dongen, J, Orfao, A, Bruggemann, M, Gaipa, G, van der Velden, V, Verbeek M. W. C., Buracchi C., Laqua A., Nierkens S., Sedek L., Flores-Montero J., Hofmans M., Sobral de Costa E., Novakova M., Mejstrikova E., Barrena S., Kohlscheen S., Szczepanowski M., Kulis J., Oliveira E., Jugooa R., de Jong A. X., Szczepanski T., Philippe J., van Dongen J. J. M., Orfao A., Bruggemann M., Gaipa G., and van der Velden V. H. J.

Abstract

The standardized EuroFlow protocol, including CD19 as primary B-cell marker, enables highly sensitive and reliable minimal residual disease (MRD) assessment in B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients treated with chemotherapy. We developed and validated an alternative gating strategy allowing reliable MRD analysis in BCP-ALL patients treated with CD19-targeting therapies. Concordant data were obtained in 92% of targeted therapy patients who remained CD19-positive, whereas this was 81% in patients that became (partially) CD19-negative. Nevertheless, in both groups median MRD values showed excellent correlation with the original MRD data, indicating that, despite higher interlaboratory variation, the overall MRD analysis was correct.

Published
2022

22. Immunophenotypic alterations of bone marrow myeloid cell compartments in multiple myeloma patients predict for myelodysplasia-associated cytogenetic alterations

Author

Matarraz, S, Paiva, B, Díez-Campelo, M, Bárrena, S, Jara-Acevedo, M, Gutiérrez, M L, Sayagués, J M, Sánchez, M-L, Bárcena, P, Garrastazul, M P, Berruezo, M J, Duran, J M, Cerveró, C, García-Erce, J A, Florensa, L, Méndez, G D, Gutierrez, O, del Cañizo, M C, van Dongen, J J M, San Miguel, J F, and Orfao, A

Published
2014
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26. Contribution of Electron Microscopy to the Classification of Minimally Differentiated Acute Leukemias in Children

Author

van Wering, E. R., Brederoo, P., van Staalduinen, G. J., van der Meulen, J., van der Linden-Schrever, B. E. M., van Dongen, J. J. M., Herfarth, Ch., editor, Senn, H.-J., editor, Baum, M., editor, Diehl, V., editor, Gutzwiller, F., editor, Rajewsky, M. F., editor, Wannenmacher, M., editor, Ludwig, Wolf-Dieter, editor, and Thiel, Eckhard, editor

Published
1993
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27. Tissue Distribution and Repertoire Selection of Human γδT Cells: Comparison With the Murine System

Author

Borst, J., Vroom, Thea M., Bos, J. D., Van Dongen, J. J. M., Compans, R. W., editor, Cooper, M., editor, Koprowski, H., editor, McConnell, I., editor, Melchers, F., editor, Nussenzweig, V., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Wilson, I., editor, Pfeffer, Klaus, editor, Heeg, Klaus, editor, Wagner, Hermann, editor, and Riethmüller, Gert, editor

Published
1991
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29. The clinical relevance of minor paroxysmal nocturnal hemoglobinuria clones in refractory cytopenia of childhood: a prospective study by EWOG-MDS

Author

Aalbers, A M, van der Velden, V H J, Yoshimi, A, Fischer, A, Noellke, P, Zwaan, C M, Baumann, I, Beverloo, H B, Dworzak, M, Hasle, H, Locatelli, F, De Moerloose, B, Göhring, G, Schmugge, M, Stary, J, Zecca, M, Langerak, A W, van Dongen, J J M, Pieters, R, Niemeyer, C M, and van den Heuvel-Eibrink, M M

Published
2014
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31. The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation

Author

Lion, T, Watzinger, F, Preuner, S, Kreyenberg, H, Tilanus, M, de Weger, R, van Loon, J, de Vries, L, Cavé, H, Acquaviva, C, Lawler, M, Crampe, M, Serra, A, Saglio, B, Colnaghi, F, Biondi, A, van Dongen, J J M, van der Burg, M, Gonzalez, M, Alcoceba, M, Barbany, G, Hermanson, M, Roosnek, E, Steward, C, Harvey, J, Frommlet, F, and Bader, P

Published
2012
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43. Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18–20 September 2008

Author

Brüggemann, M, Schrauder, A, Raff, T, Pfeifer, H, Dworzak, M, Ottmann, O G, Asnafi, V, Baruchel, A, Bassan, R, Benoit, Y, Biondi, A, Cavé, H, Dombret, H, Fielding, A K, Foà, R, Gökbuget, N, Goldstone, A H, Goulden, N, Henze, G, Hoelzer, D, Janka-Schaub, G E, Macintyre, E A, Pieters, R, Rambaldi, A, Ribera, J-M, Schmiegelow, K, Spinelli, O, Stary, J, von Stackelberg, A, Kneba, M, Schrappe, M, and van Dongen, J J M

Published
2010
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45. Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1 (Leukemia, (2019), 33, 8, (1910-1922), 10.1038/s41375-019-0413-0)

Author

Pfeifer H., Cazzaniga G., van der Velden V. H. J., Cayuela J. M., Schafer B., Spinelli O., Akiki S., Avigad S., Bendit I., Borg K., Cave H., Elia L., Reshmi S. C., Gerrard G., Hayette S., Hermanson M., Juh A., Jurcek T., Chillon M. C., Homburg C., Martinelli G., Kairisto V., Lange T., Lion T., Mueller M. C., Pane F., Rai L., Damm-Welk C., Sacha T., Schnittger S., Touloumenidou T., Valerhaugen H., Vandenberghe P., Zuna J., Serve H., Herrmann E., Markovic S., van Dongen J. J. M., Ottmann O. G., Pfeifer, H., Cazzaniga, G., van der Velden, V. H. J., Cayuela, J. M., Schafer, B., Spinelli, O., Akiki, S., Avigad, S., Bendit, I., Borg, K., Cave, H., Elia, L., Reshmi, S. C., Gerrard, G., Hayette, S., Hermanson, M., Juh, A., Jurcek, T., Chillon, M. C., Homburg, C., Martinelli, G., Kairisto, V., Lange, T., Lion, T., Mueller, M. C., Pane, F., Rai, L., Damm-Welk, C., Sacha, T., Schnittger, S., Touloumenidou, T., Valerhaugen, H., Vandenberghe, P., Zuna, J., Serve, H., Herrmann, E., Markovic, S., van Dongen, J. J. M., and Ottmann, O. G.

Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020

46. New insights to the MLL recombinome of acute leukemias

Author

Meyer, C, Kowarz, E, Hofmann, J, Renneville, A, Zuna, J, Trka, J, Ben Abdelali, R, Macintyre, E, De Braekeleer, E, De Braekeleer, M, Delabesse, E, de Oliveira, M P, Cavé, H, Clappier, E, van Dongen, J J M, Balgobind, B V, van den Heuvel-Eibrink, M M, Beverloo, H B, Panzer-Grümayer, R, Teigler-Schlegel, A, Harbott, J, Kjeldsen, E, Schnittger, S, Koehl, U, Gruhn, B, Heidenreich, O, Chan, L C, Yip, S F, Krzywinski, M, Eckert, C, Möricke, A, Schrappe, M, Alonso, C N, Schäfer, B W, Krauter, J, Lee, D A, zur Stadt, U, Te Kronnie, G, Sutton, R, Izraeli, S, Trakhtenbrot, L, Lo Nigro, L, Tsaur, G, Fechina, L, Szczepanski, T, Strehl, S, Ilencikova, D, Molkentin, M, Burmeister, T, Dingermann, T, Klingebiel, T, and Marschalek, R

Published
2009
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48. Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients

Author

Weerkamp, F, Dekking, E, Ng, Y Y, van der Velden, V H J, Wai, H, Böttcher, S, Brüggemann, M, van der Sluijs, A J, Koning, A, Boeckx, N, Van Poecke, N, Lucio, P, Mendonça, A, Sedek, L, Szczepański, T, Kalina, T, Kovac, M, Hoogeveen, P G, Flores-Montero, J, Orfao, A, Macintyre, E, Lhermitte, L, Chen, R, Brouwer-De Cock, K A J, van der Linden, A, Noordijk, A L, Comans-Bitter, W M, Staal, F J T, and van Dongen, J J M

Published
2009
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