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33 results on '"van Dongen, E. P A"'

14. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma

Author

Luykx, J. J., Bakker, S. C., Visser, W. F., Verhoeven-Duif, N., Buizer-Voskamp, J. E., den Heijer, J. M., Boks, M. P M, Sul, J. H., Eskin, E., Ori, A. P., Cantor, R. M., Vorstman, J., Strengman, E., DeYoung, J., Kappen, T. H., Pariama, E., van Dongen, E. P A, Borgdorff, P., Bruins, P., de Koning, T. J., Kahn, R. S., and Ophoff, R. A.

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Molecular Biology
Abstract

The N-methyl-d-aspartate receptor (NMDAR) coagonists glycine, d-serine and l-proline play crucial roles in NMDAR-dependent neurotransmission and are associated with a range of neuropsychiatric disorders. We conducted the first genome-wide association study of concentrations of these coagonists and their enantiomers in plasma and cerebrospinal fluid (CSF) of human subjects from the general population (N=414). Genetic variants at chromosome 22q11.2, located in and near PRODH (proline dehydrogenase), were associated with l-proline in plasma (β=0.29; P=6.38 × 10-10). The missense variant rs17279437 in the proline transporter SLC6A20 was associated with l-proline in CSF (β=0.28; P=9.68 × 10-9). Suggestive evidence of association was found for the d-serine plasma-CSF ratio at the d-amino-acid oxidase (DAO) gene (β=−0.28; P=9.08 × 10-8), whereas a variant in SRR (that encodes serine racemase and is associated with schizophrenia) constituted the most strongly associated locus for the l-serine to d-serine ratio in CSF. All these genes are highly expressed in rodent meninges and choroid plexus, anatomical regions relevant to CSF physiology. The enzymes and transporters they encode may be targeted to further construe the nature of NMDAR coagonist involvement in NMDAR gating. Furthermore, the highlighted genetic variants may be followed up in clinical populations, for example, schizophrenia and 22q11 deletion syndrome. Overall, this targeted metabolomics approach furthers the understanding of NMDAR coagonist concentration variability and sets the stage for non-targeted CSF metabolomics projects.Molecular Psychiatry advance online publication, 10 February 2015; doi:10.1038/mp.2014.190.

Published
2015

17. Letter in response to 'Testing the limits: high-sensitivity cardiac troponin in the prediction of non-cardiac complications after major abdominal surgery'

Author

Sub Pharmacotherapy, Theoretical, Sub Burgerlijk Recht, Pharmacoepidemiology and Clinical Pharmacology, UCALL / Aansprakelijkheid en verantwoordelijkheid, Noordzij, P G, Rettig, T C D, van de Garde, E M W, van Dongen, E P A, Sub Pharmacotherapy, Theoretical, Sub Burgerlijk Recht, Pharmacoepidemiology and Clinical Pharmacology, UCALL / Aansprakelijkheid en verantwoordelijkheid, Noordzij, P G, Rettig, T C D, van de Garde, E M W, and van Dongen, E P A

Published
2016

18. Peripheral blood gene expression profiles linked to monoamine metabolite levels in cerebrospinal fluid

Author

Neurogenetica, Brain, AIOS Psychiatrie, Pathologie, Affectieve & Psychotische Med., LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), Circulatory Health, Onderzoek, Luykx, J J, Olde Loohuis, L M, Neeleman, M, Strengman, E, Bakker, S C, Lentjes, E, Borgdorff, P, van Dongen, E P A, Bruins, P, Kahn, R S, Horvath, S, de Jong, S, Ophoff, R A, Neurogenetica, Brain, AIOS Psychiatrie, Pathologie, Affectieve & Psychotische Med., LKCH Staf Patiëntenzorg, Other research (not in main researchprogram), Circulatory Health, Onderzoek, Luykx, J J, Olde Loohuis, L M, Neeleman, M, Strengman, E, Bakker, S C, Lentjes, E, Borgdorff, P, van Dongen, E P A, Bruins, P, Kahn, R S, Horvath, S, de Jong, S, and Ophoff, R A

Published
2016

19. High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery

Author

Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology, Noordzij, P. G., van Geffen, O., Dijkstra, I. M., Boerma, D., Meinders, A. J., Rettig, T. C D, Eefting, F. D., van Loon, D., van de Garde, E. M W, van Dongen, E. P A, Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology, Noordzij, P. G., van Geffen, O., Dijkstra, I. M., Boerma, D., Meinders, A. J., Rettig, T. C D, Eefting, F. D., van Loon, D., van de Garde, E. M W, and van Dongen, E. P A

Published
2015

20. Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma

Author

Ontwikkelingsstoornissen Med., Brain, Neurogenetica, Affectieve & Psychotische Med., Genetica Sectie Metabole Diagnostiek, Other research (not in main researchprogram), Child Health, Onderzoeksgroep 2, Pathologie, Circulatory Health, Onderzoek, Hersenen-Bedrijfsvoering, Luykx, J. J., Bakker, S. C., Visser, W. F., Verhoeven-Duif, N., Buizer-Voskamp, J. E., den Heijer, J. M., Boks, M. P M, Sul, J. H., Eskin, E., Ori, A. P., Cantor, R. M., Vorstman, J., Strengman, E., DeYoung, J., Kappen, T. H., Pariama, E., van Dongen, E. P A, Borgdorff, P., Bruins, P., de Koning, T. J., Kahn, R. S., Ophoff, R. A., Ontwikkelingsstoornissen Med., Brain, Neurogenetica, Affectieve & Psychotische Med., Genetica Sectie Metabole Diagnostiek, Other research (not in main researchprogram), Child Health, Onderzoeksgroep 2, Pathologie, Circulatory Health, Onderzoek, Hersenen-Bedrijfsvoering, Luykx, J. J., Bakker, S. C., Visser, W. F., Verhoeven-Duif, N., Buizer-Voskamp, J. E., den Heijer, J. M., Boks, M. P M, Sul, J. H., Eskin, E., Ori, A. P., Cantor, R. M., Vorstman, J., Strengman, E., DeYoung, J., Kappen, T. H., Pariama, E., van Dongen, E. P A, Borgdorff, P., Bruins, P., de Koning, T. J., Kahn, R. S., and Ophoff, R. A.

Published
2015

23. Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR

Author

Luykx, J J, primary, Bakker, S C, additional, van Geloven, N, additional, Eijkemans, M J C, additional, Horvath, S, additional, Lentjes, E, additional, Boks, M P M, additional, Strengman, E, additional, DeYoung, J, additional, Buizer-Voskamp, J E, additional, Cantor, R M, additional, Lu, A, additional, van Dongen, E P A, additional, Borgdorff, P, additional, Bruins, P, additional, Kahn, R S, additional, and Ophoff, R A, additional

Published
2013
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24. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid

Author

Luykx, J J, primary, Bakker, S C, additional, Lentjes, E, additional, Neeleman, M, additional, Strengman, E, additional, Mentink, L, additional, DeYoung, J, additional, de Jong, S, additional, Sul, J H, additional, Eskin, E, additional, van Eijk, K, additional, van Setten, J, additional, Buizer-Voskamp, J E, additional, Cantor, R M, additional, Lu, A, additional, van Amerongen, M, additional, van Dongen, E P A, additional, Keijzers, P, additional, Kappen, T, additional, Borgdorff, P, additional, Bruins, P, additional, Derks, E M, additional, Kahn, R S, additional, and Ophoff, R A, additional

Published
2013
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25. Efficacy of an Intravenous Bolus of Morphine 2.5 versus Morphine 7.5 mg for Procedural Pain Relief in Postoperative Cardiothoracic Patients in the Intensive Care Unit: A Randomised Double-Blind Controlled Trial

Author

Ahlers, S. J. G. M., primary, Van Gulik, L., additional, Van Dongen, E. P. A., additional, Bruins, P., additional, Van De Garde, E. M. W., additional, Van Boven, W. J., additional, Tibboel, D., additional, and Knibbe, C. A. J., additional

Published
2012
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29. Peritoneal Mesothelioma without Ascites Formation

Author

Van Der Harst, E., Van Dongen, E. H. P. A., Viergever, P. P., and Meijer, W. W.

Abstract

A case of malignant peritoneal mesothelioma without development of ascites is described. The patient had a 1-year history of non-specific symptoms preceding this diagnosis. The insidious onset of clinical signs, the diagnostic procedures, and the pathologic findings are discussed.

Published
1993
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30. Anti Xa activity after high dose LMWH thrombosis prophylaxis in covid 19 patients at the intensive care unit.

Author

Vlot EA, Van den Dool EJ, Hackeng CM, Sohne M, Noordzij PG, and Van Dongen EPA

Subjects
Anticoagulants therapeutic use, Critical Illness, Heparin, Low-Molecular-Weight, Humans, Incidence, Intensive Care Units, Pandemics, Patients, SARS-CoV-2, COVID-19, Thrombosis etiology, Thrombosis prevention & control
Abstract

Introduction: Coagulopathy in Coronavirus disease 2019 (covid-19) has been demonstrated by an increase in D-dimer, prothrombin time (PT), fibrinogen and factor VIII. Venous thromboembolic events are a common abnormality in patients with covid-19. We evaluate the results of intensive care unit (ICU) thrombosis prophylaxis of 5700 international unit (IU) nadroparin low molecular weight heparin (LMWH) twice daily., Methods: After introduction of this high-dose pharmacological thrombosis prophylaxis twice weekly anti-factor Xa (anti Xa) concentrations and results from routine laboratory and viscoelastic hemostatic tests in 16 ICU covid-19 patients were evaluated., Results: During one week, median peak anti Xa activities were 0.38 [0.16-0.45] and 0.38 [0.20-0.58] at time point 1 and 2 respectively. Laboratory coagulation tests showed PT, AT and platelet count (PltC) values within normal range and markedly increased D-dimer and fibrinogen levels. Viscoelastic tests showed a maximum clot strength just above normal reference value, while fibrin clot strength was strongly increased. The overall contribution of fibrin to clot strength was high with 71 [56-85]%., Conclusion: Anti Xa activity was within the target range of pharmacodynamic endpoint for covid-19 patients but viscoelastic tests still demonstrated a procoagulant pattern., (Copyright © 2020. Published by Elsevier Ltd.)

Published
2020
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32. High-sensitive cardiac troponin T measurements in prediction of non-cardiac complications after major abdominal surgery.

Author

Noordzij PG, van Geffen O, Dijkstra IM, Boerma D, Meinders AJ, Rettig TC, Eefting FD, van Loon D, van de Garde EM, and van Dongen EP

Subjects
Aged, Cohort Studies, Endpoint Determination, Female, Hospital Mortality, Humans, Length of Stay, Male, Middle Aged, Odds Ratio, Postoperative Complications mortality, Predictive Value of Tests, Prospective Studies, Abdomen surgery, Myocardium metabolism, Postoperative Complications blood, Troponin T metabolism
Abstract

Background: Postoperative non-cardiac complication rates are as high as 11-28% after high-risk abdominal procedures. Emerging evidence indicates that postoperative cardiac troponin T elevations are associated with adverse outcome in non-cardiac surgery. The aim of this study was to determine the relationship between postoperative high-sensitive cardiac troponin T elevations and non-cardiac complications in patients after major abdominal surgery., Methods: This prospective observational single-centre cohort study included patients at risk for coronary artery disease undergoing elective major abdominal surgery. Cardiac troponin was measured before surgery and at day 1, 3, and 7. Multivariable logistic regression analysis was performed to examine the adjusted association for different cut-off concentrations of postoperative myocardial injury and non-cardiac outcome., Results: In 203 patients, 690 high-sensitive cardiac troponin T measurements were performed. Fifty-three patients (26%) had a non-cardiac complication within 30 days after surgery. Hospital mortality was 4% (8/203). An increase in cardiac troponin T concentration ≥100% compared with baseline was a superior independent predictor of non-cardiac postoperative clinical complications (adjusted odds ratio 4.3, 95% confidence interval 1.8-10.1, P<0.001) and was associated with increased length of stay (9 days, 95% confidence interval 7-11 vs 7 days, 95% confidence interval 6-8, P=0.004) and increased hospital mortality (12 vs 2%, P=0.028)., Conclusions: A postoperative high-sensitive cardiac troponin T increase ≥100% is a strong predictor of non-cardiac 30 day complications, increased hospital stay and hospital mortality in patients undergoing major abdominal surgery., Clinicaltrialsgov Identifier: NCT02150486., (© The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)

Published
2015
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33. An integrated population pharmacokinetic meta-analysis of propofol in morbidly obese and nonobese adults, adolescents, and children.

Author

Diepstraten J, Chidambaran V, Sadhasivam S, Blussé van Oud-Alblas HJ, Inge T, van Ramshorst B, van Dongen EP, Vinks AA, and Knibbe CA

Abstract

This study describes a population pharmacokinetic meta-analysis of propofol to characterize the influence of body size measures and age in morbidly obese and nonobese adults, adolescents, and children. Sixty morbidly obese and nonobese adult patients (55-167 kg; 21-79 years) and 34 morbidly obese and nonobese adolescents and children (37-184 kg; 9-20 years) were included. The results show that clearance increased with total body weight in an allometric function while age was found to influence clearance in a bilinear fashion with two distinct slopes, reflecting an initial increase and subsequent decrease as a result of aging. Using these two functions, the influence of both (over)weight and age on propofol clearance was well characterized, which may provide a basis for dosing across this diverse group of patients.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e73; doi:10.1038/psp.2013.47; advance online publication 11 September 2013.

Published
2013
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