542 results on '"van Dommelen, P"'
Search Results
2. Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration
- Author
-
van Dommelen, Julia E. M., Grootjans, Heleen, Uijtendaal, Esther V., Ruigrok, Dieuwertje, Luijk, Bart, van Luin, Matthijs, Bult, Wouter, de Lange, Dylan W., Kusadasi, Nuray, Droogh, Joep M., Egberts, Toine C. G., Verschuuren, Erik A. M., and Sikma, Maaike A.
- Published
- 2024
- Full Text
- View/download PDF
3. Short developmental milestone risk assessment tool to identify Duchenne muscular dystrophy in primary care
- Author
-
van Dommelen, Paula, van Dijk, Oisín, de Wilde, Jeroen A., and Verkerk, Paul H.
- Published
- 2024
- Full Text
- View/download PDF
4. The association between serum vitamin D status and dental caries or molar incisor hypomineralisation in 7–9-year-old Norwegian children: a cross-sectional study
- Author
-
Børsting, Torunn, Fagerhaug, Tone Natland, Schuller, Annemarie, van Dommelen, Paula, Stafne, Signe Nilssen, Mørkved, Siv, Stunes, Astrid Kamilla, Gustafsson, Miriam K., Syversen, Unni, Sun, Yi-Qian, and Skeie, Marit S.
- Published
- 2024
- Full Text
- View/download PDF
5. Short developmental milestone risk assessment tool to identify Duchenne muscular dystrophy in primary care
- Author
-
Paula van Dommelen, Oisín van Dijk, Jeroen A. de Wilde, and Paul H. Verkerk
- Subjects
Pediatrics ,neuromuscular disorder ,Child Development ,Developmental Delay ,Early Childhood Development ,Motor skills ,Medicine - Abstract
Abstract Background In patients without a family history, Duchenne muscular dystrophy (DMD) is typically diagnosed at around 4–5 years of age. It is important to diagnose DMD during infancy or toddler stage in order to have timely access to treatment, opportunities for reproductive options, prevention of potential fatal reactions to inhaled anesthetics, awareness of a child’s abilities needed for good parenting, and opportunities for enrolment in clinical trials. Method We aimed to develop a short risk assessment tool based on developmental milestones that may contribute to the early detection of boys with DMD in primary care. As part of the case-control 4D-DMD study (Detection by Developmental Delay in Dutch boys with DMD), data on developmental milestones, symptoms and therapies for 76 boys with DMD and 12,414 boys from a control group were extracted from the health records of youth health care services and questionnaires. Multiple imputation, diagnostic validity and pooled backward logistic regression analyses with DMD (yes/no) as the dependent variable and attainment of 26 milestones until 36 months of age (yes/no) as the independent variable were performed. Descriptive statistics on symptoms and therapies were provided. Results A tool with seven milestones assessed at specific ages between 12 and 36 months resulted in a sensitivity of 79% (95CI:67–88%), a specificity of 95.8% (95%CI:95.3–96.2), and a positive predictive value of 1:268 boys. Boys with DMD often had symptoms (e.g. 43% had calf muscle pseudohypertrophy) and were referred to therapy (e.g. 59% for physical therapy) before diagnosis. Discussion This tool followed by the examination of other DMD-related symptoms could be used by youth health care professionals during day-to-day health assessments in the general population to flag children who require further action. Conclusions The majority of boys (79%) with DMD can be identified between 12 and 36 months of age with this tool. It increases the initial a priori risk of DMD from 1 in 5,000 to approximately 1 in 268 boys. We expect that other neuromuscular disorders and disabilities can also be found with this tool.
- Published
- 2024
- Full Text
- View/download PDF
6. Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy
- Author
-
Paul Dimitri, Paula van Dommelen, Indraneel Banerjee, Riccardo Bellazzi, Marta Ciaccio, Antonio de Arriba Muñoz, Sandro Loche, Azriyanti Anuar Zaini, Ammar Halabi, Merat Bagha, and Ekaterina Koledova
- Subjects
decision support ,digital ,growth hormone ,pediatric ,technology ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Smart technologies and connected health are providing opportunities for improved healthcare for chronic conditions. Acceptance by healthcare professionals (HCPs) and patients is crucial for successful implementation. Evidence-based standards, technological infrastructure and regulatory processes are needed to integrate digital tools into clinical practice. Personal health records provide continuity and aid decision-making, while machine-learning algorithms may help in optimizing therapies and improving outcomes. Digital healthcare can negate geographical barriers, enabling patients in remote areas to access specialist endocrine expertise. We review available and developing digital tools to manage care for patients requiring growth hormone (GH) therapy for growth failure conditions. GH is most often administered via daily injections over several years; continuous adherence is necessary but may become insufficient. Future development and integration of electronic platforms for GH therapy requires involvement of all stakeholders in design-thinking approaches and human-factor testing. Growzen Connect is an innovative digital ecosystem designed to increase the management and monitoring of GH therapy, comprising the easypod device and connected mobile apps. It provides a real-time overview of a patient’s therapy, including adherence and growth response, which aids decision-making by HCPs and empowers patients to engage in their therapy journey. Incorporating prediction models for adherence and growth in the ecosystem helps patients build treatment habits and allows issues to be addressed in a timely fashion. A connected ecosystem for GH therapy can enhance outcomes and empower patients, fostering a collaborative and patient-centered approach that is more proactive, beyond the traditional clinic-based approach.
- Published
- 2024
- Full Text
- View/download PDF
7. Use of connected injection device has a positive effect on catch-up growth in patients with growth disorders treated with growth hormone therapy
- Author
-
Antonio de Arriba, Paula van Dommelen, and Martin O. Savage
- Subjects
growth hormone ,adherence ,growth response ,height gain ,digital tool ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionHuman growth hormone (hGH) therapy in children can be administered by subcutaneous injection using either a manual non-connected device, which is a portable injection pen loaded with a pre-filled cartridge, or an electronic connected device. The electronic device is connected to a platform where adherence data is recorded and available for health care professionals (HCPs) and patient support programs. Real-world data used in the clinic, includes regular monitoring of adherence data which are shared with families during patients’ visits and aim to determine the root causes of poor adherence. This study aimed to identify whether there are differences in growth during the first four years of treatment depending on the device, i.e. non-connected versus connected devices.MethodsThis retrospective study reports treatment of either GH deficiency or short stature secondary to birth size small for gestational age (SGA) in 174 pediatric patients attending Miguel Servet Hospital, Zaragoza, Spain. hGH treatment was administered with manual non-connected devices in 87 patients and 87 patients used connected devices. Height was followed for 4 years after start of hGH therapy.ResultsIn total, 57% of subjects had GHD and 43% were SGA. Height standard deviation score (HSDS) at treatment start was higher (p
- Published
- 2024
- Full Text
- View/download PDF
8. Health status and public health needs in a Togolese child health care centre modelled after the Dutch system
- Author
-
Paula van Dommelen, Cécile Schat-Savy, Arjan Huizing, Symone Detmar, Leonhard A. Bakker, and Paul H. Verkerk
- Subjects
Community child health ,primary care ,public health ,Biology (General) ,QH301-705.5 ,Human anatomy ,QM1-695 ,Physiology ,QP1-981 - Abstract
AbstractBackground The charity foundation Association Soutien Enfants Togo started a child health care (CHC) centre in Togo that was modelled after the Dutch high-quality CHC system to improve child health.Aim To describe health care data of children who visited the centre.Subjects and methods Data were routinely collected between October 2010-July 2017. Outcomes were completed vaccinations, growth, development, lifestyle, physical examination, and laboratory testing results.Results In total, 8,809 children aged 0–24 years were available. Half (47.5%) of children aged 0–4 years did not receive all eligible free vaccinations from the government. The proportions of stunted children (all) or with a developmental delay (0–4 years) were 10.1% and 9.5%, respectively. In total, 40–50% of all children did not wash their hands with soap after toilet or before eating, or did not use clean drinking water. Furthermore, 5.1–6.6% had insufficient vision, high eye pressure or hearing loss. Sickle cell disease was detected in 5.3%.Conclusion A large group of children in need of prevention and early treatment were detected, informed and treated by the centre. Further research is needed to confirm if this strategy can improve children’s health in Sub-Saharan Africa. Our data are available for further research.
- Published
- 2024
- Full Text
- View/download PDF
9. The growzen™ buddy smartphone app to improve adherence in patients receiving recombinant human growth hormone therapy: a retrospective observational study in Argentina
- Author
-
Paula van Dommelen, Lilian Arnaud, Aria Reza Assefi, Maria Lourdes Crespo, Matias Debicki, Fulvio Michelis, and Ekaterina Koledova
- Subjects
application ,growth disorders ,growzen ,patient support program ,recombinant human growth hormone ,smartphone ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionThis study in Argentina evaluated the impact of the growzen™ buddy smartphone app on adherence to recombinant human growth hormone (r-hGH) treatment.MethodsThe adherence data, invitation dates with a link to the app, app activation dates, and height measurements entered were extracted from the growzen™ digital health ecosystem. Patients with 12 months of adherence data, aged ≥2 years at treatment start, and aged
- Published
- 2024
- Full Text
- View/download PDF
10. The association between serum vitamin D status and dental caries or molar incisor hypomineralisation in 7–9-year-old Norwegian children: a cross-sectional study
- Author
-
Torunn Børsting, Tone Natland Fagerhaug, Annemarie Schuller, Paula van Dommelen, Signe Nilssen Stafne, Siv Mørkved, Astrid Kamilla Stunes, Miriam K. Gustafsson, Unni Syversen, Yi-Qian Sun, and Marit S. Skeie
- Subjects
Oral health ,Dental caries ,Molar incisor hypomineralisation ,MIH ,Vitamin D ,Child health ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Research focusing on the association between serum vitamin D and oral health outcomes in children, such as dental caries and molar incisor hypomineralisation (MIH), shows inconsistent results. Previous studies have predominantly investigated dental caries and MIH as dichotomized outcomes, which limits the information on their distribution. In addition, the methods used for analysing serum vitamin D have varied. The present study aimed to investigate potential associations between serum vitamin D status measured by Liquid Chromatography with Tandem Mass Spectrometry (LC-MS/MS) and the prevalence, as well as the number of teeth, affected by dental caries or MIH among 7–9-year-old Norwegian children. Methods The study had a cross-sectional design and included 101 children aged 7–9 years. Serum 25-hydroxyvitamin D (25(OH)D) was measured and included as continuous (per 25 nmol/l) and categorised (insufficient (
- Published
- 2024
- Full Text
- View/download PDF
11. LiMeS-Lab: An Integrated Laboratory for the Development of Liquid–Metal Shield Technologies for Fusion Reactors
- Author
-
Tanke, V. F. B., Al, R. S., Alonso van der Westen, S., Brons, S., Classen, I. G. J., van Dommelen, J. A. W., van Eck, H. J. N., Geers, M. G. D., Lopes Cardozo, N. J., van der Meiden, H. J., Orrico, C. A., van de Pol, M. J., Riepen, M., Rindt, P., de Rooij, T. P., Scholten, J., Timmer, R. H. M., Vernimmen, J. W. M., Vos, E. G. P., and Morgan, T. W.
- Published
- 2023
- Full Text
- View/download PDF
12. Digital manufacturing of personalised footwear with embedded sensors
- Author
-
Binelli, Marco R., van Dommelen, Ryan, Nagel, Yannick, Kim, Jaemin, Haque, Rubaiyet I., Coulter, Fergal B., Siqueira, Gilberto, Studart, André R., and Briand, Danick
- Published
- 2023
- Full Text
- View/download PDF
13. Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA repair protein MPG
- Author
-
Thi Tham Nguyen, Premnath Rajakannu, Minh Diêu Thanh Pham, Leo Weman, Alexander Jucht, Michelle C. Buri, Kristof Van Dommelen, and Monika E. Hegi
- Subjects
DNA damage repair ,epigenetic silencing ,GBM ,nuclear–cytoplasmic translocation ,treatment resistance ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Glioblastoma, the most malignant brain tumor in adults, exhibits characteristic patterns of epigenetic alterations that await elucidation. The DNA methylome of glioblastoma revealed recurrent epigenetic silencing of HTATIP2, which encodes a negative regulator of importin β‐mediated cytoplasmic–nuclear protein translocation. Its deregulation may thus alter the functionality of cancer‐relevant nuclear proteins, such as the base excision repair (BER) enzyme N‐methylpurine DNA glycosylase (MPG), which has been associated with treatment resistance in GBM. We found that induction of HTATIP2 expression in GBM cells leads to a significant shift of predominantly nuclear to cytoplasmic MPG, whereas depletion of endogenous HTATIP2 results in enhanced nuclear MPG localization. Reduced nuclear MPG localization, prompted by HTATIP2 expression or by depletion of MPG, yielded less phosphorylated‐H2AX‐positive cells upon treatment with an alkylating agent. This suggested reduced MPG‐mediated formation of apurinic/apyrimidinic sites, leaving behind unrepaired DNA lesions, reflecting a reduced capacity of BER in response to the alkylating agent. Epigenetic silencing of HTATIP2 may thus increase nuclear localization of MPG, thereby enhancing the capacity of the glioblastoma cells to repair treatment‐related lesions and contributing to treatment resistance.
- Published
- 2023
- Full Text
- View/download PDF
14. An eight-year follow-up on auditory outcomes after neonatal hearing screening.
- Author
-
Jolien J G Kleinhuis, Karin de Graaff-Korf, Henrica L M van Straaten, Paula van Dommelen, and Michel R Benard
- Subjects
Medicine ,Science - Abstract
ObjectiveThe aim of this study is to assess the neonatal click Auditory Brainstem Response (ABR) results in relation to the subsequently determined mean hearing loss (HL) over 1, 2 and 4 kHz, as well as over 2 and 4 kHz.MethodsBetween 2004-2009, follow-up data were collected from Visual Reinforcement Audiometry (VRA) at 1 and 2 years and playaudiometry at 4 and 8 years of newborns who had failed neonatal hearing screening in the well-baby clinics and who had been referred to a single Speech and Hearing center. Hearing Level data were compared with ABR threshold-levels established during the first months of life. The Two One-Sided Tests equivalence procedure for paired means was applied, using a region of similarity equal to 10 dB.ResultsInitially, in 135 out of 172 children referred for diagnostic procedures hearing loss was confirmed in the neonatal period. In 106/135 of the HL children the eight-year follow-up was completed. Permanent conductive HL was established in 5/106 cases; the hearing thresholds were predominantly stable over time. Temporary conductive HL was found in 48/106 cases and the loss disappeared by 4 years of age at the latest. Sensorineural hearing loss (SNHL) was found in 53/106 cases, of which 13 were unilateral and 40 bilateral. ABR levels were equivalent (within a 10 dB range) to VRA levels at age 1 and 2 and play audiometry levels at age 4 and 8, both when VRA and play audiometry were averaged over both frequency ranges.ConclusionLong term follow-up data of children with SNHL suggest that the initial click ABR level established in the first months of life, are equivalent to the hearing threshold measured at the age of 1, 2, 4 and 8 years for both mean frequency ranges. Click ABR can reliably be used as starting point for long-term hearing rehabilitation.
- Published
- 2024
- Full Text
- View/download PDF
15. Correction: An eight-year follow-up on auditory outcomes after neonatal hearing screening.
- Author
-
Jolien J G Kleinhuis, Karin de Graaff-Korf, Henrica L M van Straaten, Paula van Dommelen, and Michel R Benard
- Subjects
Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0297363.].
- Published
- 2024
- Full Text
- View/download PDF
16. Amorphous and anisotropic surface relief formation in tungsten under repeated high-flux hydrogen plasma loads
- Author
-
Yu Li, Junhua Hou, Varun Shah, Yuhe Huang, Johannes A.W. van Dommelen, Wenjun Lu, Qiang Zhu, and Thomas W. Morgan
- Subjects
Thermal fatigue ,Amorphization ,Orientation-dependence ,Hydrogen plasma ,Superabundant vacancies ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
Facing extreme plasma loads, the structural integrity of the tungsten divertor is crucial for ITER, an engineering marvel in nuclear fusion reactors, to achieve its fusion performance targets. Induced by repeated transient heating from plasmas, the thermal fatigue damage of tungsten–typically accompanied by the formation of surface relief–has been identified as a critical issue but an in-depth understanding is still lacking. Here, we report the formation of amorphous and anisotropic surface relief on ITER-grade tungsten surfaces under ITER-relevant hydrogen plasma loads. Measured by both electron backscatter diffraction over large fields of view and transmission Kikuchi diffraction of site-specific lamellae, such surface relief preferentially forms on grains with {110} planes parallel to the surface. This cannot be explained by the orientation-dependent resolved shear stress according to the Schmid law, threshold displacement energy anisotropy, or oxidation anisotropy. Furthermore, surface relief amorphization is revealed by high-resolution transmission electron microscopy imaging and selected area electron diffraction analysis, and is explained by a novel vacancy-induced amorphization mechanism. The results provide new insights into the thermal fatigue behavior of tungsten for fusion applications.
- Published
- 2023
- Full Text
- View/download PDF
17. The Impact of COVID-19 Regulations on Adherence to Recombinant Human Growth Hormone Therapy: Evidence from Real-World Data
- Author
-
Paula van Dommelen, Rosa Maria Baños, Lilian Arnaud, Quentin Le Masne, and Ekaterina Koledova
- Subjects
adherence ,COVID-19 ,growth disorders ,injection device ,lockdown ,recombinant human growth hormone (r-hGH) ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March 2019–February 2020 (before COVID-19) and March 2020–February 2021 (during COVID-19) from the easypod™ connect ecosystem. Data from three measures of regulations were analysed: stringency index (SI), school closure and stay-at-home. The mean SI, and the proportion of days with required school closure or stay-at-home during COVID-19 were categorised as high versus medium/low based on the 75th percentile. Adherence was categorised as optimal (≥85%) versus suboptimal (p < 0.001). Stay-at-home requirements showed no statistically significant effect (p = 0.13). Stringent COVID-19 regulations resulted in improved adherence to r-hGH therapy in patients with growth disorders, supported by connected digital health technologies. Insights into patient behavior during this time are useful to understand potential influences and strategies to improve long-term adherence to r-hGH.
- Published
- 2023
- Full Text
- View/download PDF
18. Digital manufacturing of personalised footwear with embedded sensors
- Author
-
Marco R. Binelli, Ryan van Dommelen, Yannick Nagel, Jaemin Kim, Rubaiyet I. Haque, Fergal B. Coulter, Gilberto Siqueira, André R. Studart, and Danick Briand
- Subjects
Medicine ,Science - Abstract
Abstract The strong clinical demand for more accurate and personalized health monitoring technologies has called for the development of additively manufactured wearable devices. While the materials palette for additive manufacturing continues to expand, the integration of materials, designs and digital fabrication methods in a unified workflow remains challenging. In this work, a 3D printing platform is proposed for the integrated fabrication of silicone-based soft wearables with embedded piezoresistive sensors. Silicone-based inks containing cellulose nanocrystals and/or carbon black fillers were thoroughly designed and used for the direct ink writing of a shoe insole demonstrator with encapsulated sensors capable of measuring both normal and shear forces. By fine-tuning the material properties to the expected plantar pressures, the patient-customized shoe insole was fully 3D printed at room temperature to measure in-situ gait forces during physical activity. Moreover, the digitized approach allows for rapid adaptation of the sensor layout to meet specific user needs and thereby fabricate improved insoles in multiple quick iterations. The developed materials and workflow enable a new generation of fully 3D printed soft electronic devices for health monitoring.
- Published
- 2023
- Full Text
- View/download PDF
19. Can cats cause colossal contagious cutaneous carbuncles?
- Author
-
Henckens, NFT, Rovers, JFJ, van Dommelen, L, and Bovenschen, HJ
- Subjects
animal ,cat ,skin infection ,Sporothrix braziliensis ,sporotrichosis - Abstract
Sporothrix spp. cause the most common deep fungal skin infections in Brazil and this is related to infected cats. Transmission is traditionally from organic material/plants but can also be zoonotic. Culture of a skin biopsy is the golden standard for determination. Treatment with oral itraconazole approaches up to 95% efficacy in patients with cutaneous sporotrichosis.
- Published
- 2021
20. Using GIS-based spatial analysis to determine urban greenspace accessibility for different racial groups in the backdrop of COVID-19: a case study of four US cities
- Author
-
Pallathadka, Arun, Pallathadka, Laxmi, Rao, Sneha, Chang, Heejun, and Van Dommelen, Dorn
- Published
- 2022
- Full Text
- View/download PDF
21. Controlled irradiation hardening of tungsten by cyclic recrystallization
- Author
-
Mannheim, A., van Dommelen, J. A. W., and Geers, M. G. D.
- Subjects
Condensed Matter - Materials Science - Abstract
The economical lifetime of the divertor is a key concern for realizing nuclear fusion reactors that may solve the world's energy problem. A main risk is thermo-mechanical failure of the plasma-facing tungsten monoblocks, as a consequence of irradiation hardening induced by neutron displacement cascades. Lifetime extensions that could be carried out without prolonged maintenance periods are desired. In this work, the effects of potential treatments for extending the lifetime of an operational reactor are explored. The proposed treatments make use of cyclic recrystallization processes that can occur in neutron-irradiated tungsten. Evolution of the microstructure under non-isothermal conditions is investigated, employing a multi-scale model that includes a physically-based mean-field recrystallization model and a cluster dynamics model for neutron irradiation effects. The model takes into account microstructural properties such as grain size and displacement-induced defect concentrations. The evolution of a hardness indicator under neutron irradiation was studied. The results reveal that, for the given microstructure and under the assumed model behaviour, periodical extra heating can have a significant positive influence on controlling the irradiation hardening. For example, at 800 C, if extra annealing at 1200 C was applied after every 100 hrs for the duration of 1 hr, then the hardness indicator reduces from maximum 140 to below 70.
- Published
- 2019
- Full Text
- View/download PDF
22. Long-term microstructural evolution of tungsten under heat and neutron loads
- Author
-
Mannheim, A., van Dommelen, J. A. W., and Geers, M. G. D.
- Subjects
Condensed Matter - Materials Science - Abstract
In nuclear fusion reactors, tungsten will be exposed to high neutron loads at high temper atures (>900 C). The evolution and degradation of the mechanical properties under these conditions is uncertain and therefore constitutes a major risk. Here, the microstructural evolution of tungsten under combined heat and neutron loads is studied, using a multi-scale approach incorporating clusters dynamics and a mean-field recrystallization model. The mean-field recrystallization model contains both nucleation in the bulk and at the grain boundaries. The cluster dynamics model includes the incorporation of loops in the dynamics of the dislocation network as a mechanism. The effects of bulk nucleation on the microstructural evolution are explored. The simulations predict a cyclically occuring neutron-induced recrystallization at all studied temperatures. Furthermore, the evolution of the irradiation hardening during neutron-induced recrystallization is assessed from the simulated microstructures., Comment: Submitted to peer-reviewed journal
- Published
- 2019
23. A modular framework to obtain representative microstructural cells of additively manufactured parts
- Author
-
L. Palmeira Belotti, J.P.M. Hoefnagels, M.G.D. Geers, and J.A.W. van Dommelen
- Subjects
Additive manufacturing ,Repeating microstructures ,Representative microstructural cell ,Image processing ,Representative volume element ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The repeating nature of additive manufacturing (AM) translates into quasi-periodic repeating hierarchical microstructures, which vary depending on the working principle of the AM technology. The geometry and internal characteristics of these repeating microstructures affect the geometrical accuracy and mechanical properties of AM parts. We propose a modular and generic framework for AM microstructures to automatically determine a representative microstructural cell with average shape and microstructural information based on micrograph processing and morphological shape analyses. A general microstructural mapping procedure is presented to map and average different microstructural features inside the representative cell. Moreover, an extension of the method is proposed to recover a representative cell with a periodic shape as required for subsequent numerical micromechanical simulations under periodic boundary conditions to unravel process-structure–property relationships. The framework is demonstrated on a virtually generated microstructure and on the metallic and polymeric microstructure of two parts manufactured with different AM processes, showing the framework's versatility for different materials and AM technologies. The three test cases show the framework's modularity, where different procedures were applied to overcome the challenges of each particular case while keeping the primary method the same. We also discuss applications of the framework, such as enabling statistical investigations of spatial variations of the microstructural features across AM parts and providing essential input for microstructural and mechanical numerical simulations.
- Published
- 2022
- Full Text
- View/download PDF
24. Filmpjes voor het afnemen van de Van Wiechenkenmerken door ouders: determinanten van gebruik
- Author
-
van Dommelen, P., Beek, D., van Zoonen, R., Wildeman, I., Verkerk, P. H., and Schönbeck, Y.
- Published
- 2022
- Full Text
- View/download PDF
25. Maternal vitamin D status in pregnancy and molar incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7–9 years of age: a longitudinal study
- Author
-
Børsting, T., Schuller, A., van Dommelen, P., Stafne, S. N., Skeie, M. S., Skaare, A. B., Mørkved, S., Salvesen, K. Å., Stunes, A. K., Mosti, M. P., Gustafsson, M. K., Syversen, U., and Fagerhaug, T. N.
- Published
- 2022
- Full Text
- View/download PDF
26. Aspergillus Outbreak in an Intensive Care Unit: Source Analysis with Whole Genome Sequencing and Short Tandem Repeats
- Author
-
Stephan J. P. Hiel, Amber C. A. Hendriks, Jos J. A. Eijkenboom, Thijs Bosch, Jordy P. M. Coolen, Willem J. G. Melchers, Paul Anröchte, Simone M. T. Camps, Paul E. Verweij, Jianhua Zhang, and Laura van Dommelen
- Subjects
Aspergillus fumigatus ,construction work ,source analysis ,whole genome sequencing ,Biology (General) ,QH301-705.5 - Abstract
Whole genome sequencing (WGS) is widely used for outbreak analysis of bacteriology and virology but is scarcely used in mycology. Here, we used WGS for genotyping Aspergillus fumigatus isolates from a potential Aspergillus outbreak in an intensive care unit (ICU) during construction work. After detecting the outbreak, fungal cultures were performed on all surveillance and/or patient respiratory samples. Environmental samples were obtained throughout the ICU. WGS was performed on 30 isolates, of which six patient samples and four environmental samples were related to the outbreak, and twenty samples were unrelated, using the Illumina NextSeq 550. A SNP-based phylogenetic tree was created from outbreak samples and unrelated samples. Comparative analysis (WGS and short tandem repeats (STRs), microsatellite loci analysis) showed that none of the strains were related to each other. The lack of genetic similarity suggests the accumulation of Aspergillus spores in the hospital environment, rather than a single source that supported growth and reproduction of Aspergillus fumigatus. This supports the hypothesis that the Aspergillus outbreak was likely caused by release of Aspergillus fumigatus spores during construction work. Indeed, no new Aspergillus cases were observed in the ICU after cessation of construction. This study demonstrates that WGS is a suitable technique for examining inter-strain relatedness of Aspergillus fumigatus in the setting of an outbreak investigation.
- Published
- 2024
- Full Text
- View/download PDF
27. Intrinsic mechanical properties of food in relation to texture parameters
- Author
-
Jonkers, N., van Dommelen, J. A. W., and Geers, M. G. D.
- Published
- 2022
- Full Text
- View/download PDF
28. Adherence to r-hGH Therapy in Pediatric Growth Hormone Deficiency: Current Perspectives on How Patient-Generated Data Will Transform r-hGH Treatment Towards Integrated Care
- Author
-
Savage MO, Fernandez-Luque L, Graham S, van Dommelen P, Araujo M, de Arriba A, and Koledova E
- Subjects
behavioral support ,data ,digital ,growth ,participatory medicine ,Medicine (General) ,R5-920 - Abstract
Martin O Savage,1 Luis Fernandez-Luque,2 Selina Graham,3 Paula van Dommelen,4 Matheus Araujo,5 Antonio de Arriba,6 Ekaterina Koledova7 1Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, London, UK; 2Adhera Health Inc., Palo Alto, CA, USA; 3King’s College London, London, UK; 4The Netherlands Organization for Applied Scientific Research TNO, Leiden, the Netherlands; 5Neurological Institute; Cleveland Clinic, Cleveland, OH, USA; 6Paediatric Endocrinology, Hospital Universitario Miguel Servet, Zaragoza, Spain; 7Global Medical Affairs Cardiometabolic & Endocrinology, Merck Healthcare KGaA, Darmstadt, GermanyCorrespondence: Martin O Savage, Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Charterhouse Square, London, EC1M 6BQ, UK, Tel +44 7803084491, Email m.o.savage@qmul.ac.ukAbstract: Pediatric growth hormone (GH) deficiency is a licensed indication for replacement therapy with recombinant human growth hormone (r-hGH). Treatment, consisting of daily subcutaneous injections, extends from the time of diagnosis until cessation of linear growth at completion of puberty. Suboptimal adherence to r-hGH therapy is common and has been well documented to substantially impair the growth response and achievement of the optimal goal which is attainment of adult height within the genetic target range. The causes of poor adherence are complex and include disease-, patient-, doctor-, and treatment-related factors. Interventions for suboptimal adherence are important for a long-term successful outcome and can include both face-to-face and digital strategies. Face-to-face interventions include behavioral change approaches such as motivational interviewing and non-judgmental assessment. Medical and nursing staff require training in these techniques. Digital solutions are rapidly advancing as evidenced by the electronic digital auto-injector device, easypod® (Merck Healthcare KGaA, Darmstadt, Germany), which uses the web-based easypod® connect platform allowing adherence data to be transmitted electronically to healthcare professionals (HCPs), who can then access GH treatment history, enhancing clinical decisions. Over the past 10 years, the multi-national Easypod® Connect Observational Study has reported high levels of adherence (> 85%) from up to 40 countries. The easypod® connect system can be supported by a smartphone app, growlink™, which facilitates the interactions between the patients, their care team, and patient support services. HCPs are empowered by new digital techniques, however, the human–digital partnership remains essential for optimal growth management. The pediatric patient on r-hGH therapy will benefit from these innovations to enhance adherence and optimize long-term response.Keywords: behavioral support, data, digital, growth, participatory medicine
- Published
- 2022
29. Use of machine learning to identify patients at risk of sub-optimal adherence: study based on real-world data from 10,929 children using a connected auto-injector device
- Author
-
Amalia Spataru, Paula van Dommelen, Lilian Arnaud, Quentin Le Masne, Silvia Quarteroni, and Ekaterina Koledova
- Subjects
Adherence ,Auto-injector ,Connected device ,Digital health ,Indicator ,Machine learning ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Our aim was to develop a machine learning model, using real-world data captured from a connected auto-injector device and from early indicators from the first 3 months of treatment, to predict sub-optimal adherence to recombinant human growth hormone (r-hGH) in patients with growth disorders. Methods Adherence to r-hGH treatment was assessed in children (aged
- Published
- 2022
- Full Text
- View/download PDF
30. Rates of spectacle wear in early childhood in the Netherlands
- Author
-
Vasanthi Iyer, Clair A. Enthoven, Paula van Dommelen, Ashwin van Samkar, Johanna H. Groenewoud, Vincent V. W. Jaddoe, Sijmen A. Reijneveld, and Caroline C. W. Klaver
- Subjects
Refractive error ,Spectacle wear ,Myopia ,Well-child care ,Policy ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Refractive errors are relatively common all around the world. In particular, early onset myopia is associated with a significant burden in later life. Little is known about refractive errors in preschool children. The aim of this study was to assess the prevalence of spectacle wear, visual acuity and refractive errors in young Dutch children. Methods We analyzed data of three prospective population-based studies: 99,660 3- to 5-year-olds undergoing vision screening at preventive child healthcare organizations, 6934 6-year-olds from the Generation R study, and 2974 7-year-olds from the RAMSES study. Visual acuity was measured with Landolt-C or LEA charts, spectacle wear was assessed, and refractive errors at age 6 and 7 were measured with cycloplegic refraction. Results The prevalence of spectacle wear ranged from 1.5 to 11.8% between 3 to 7 years with no significant gender differences. Among children with spectacle wear at 6 years (N = 583) and 7 years (N = 350) 29.8 and 34.6% had myopia respectively, of which 21.1 and 21.6% combined with astigmatism; 19.6 and 6.8% had hyperopia, 37.2 and 11.1% hyperopia and astigmatism, and 12.5 and 32.7% astigmatism only. Conclusions Spectacle wear in European children starts early in preschool and increases to a relatively frequent visual aid at school age. Advocating early detection and monitoring of refraction errors is warranted in order to prevent visual morbidities later in life.
- Published
- 2022
- Full Text
- View/download PDF
31. Culture density influences the functional phenotype of human macrophages
- Author
-
Adele V. Ruder, Lieve Temmerman, Joep M.A. van Dommelen, Jan Nagenborg, Chang Lu, Judith C. Sluimer, Pieter Goossens, and Erik A.L. Biessen
- Subjects
macrophage ,quorum sensing ,culture density ,in vitro ,macrophage function ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Macrophages (MΦ) are commonly cultured in vitro as a model of their biology and functions in tissues. Recent evidence suggests MΦ to engage in quorum sensing, adapting their functions in response to cues about the proximity of neighboring cells. However, culture density is frequently overlooked in the standardization of culture protocols as well as the interpretation of results obtained in vitro. In this study, we investigated how the functional phenotype of MΦ was influenced by culture density. We assessed 10 core functions of human MΦ derived from the THP-1 cell line as well as primary monocyte-derived MΦ. THP-1 MΦ showed increasing phagocytic activity and proliferation with increasing density but decreasing lipid uptake, inflammasome activation, mitochondrial stress, and secretion of cytokines IL-10, IL-6, IL-1β, IL-8, and TNF-α. For THP-1 MΦ, the functional profile displayed a consistent trajectory with increasing density when exceeding a threshold (of 0.2 x 103 cells/mm2), as visualized by principal component analysis. Culture density was also found to affect monocyte-derived MΦ, with functional implications that were distinct from those observed in THP-1 MΦ, suggesting particular relevance of density effects for cell lines. With increasing density, monocyte-derived MΦ exhibited progressively increased phagocytosis, increased inflammasome activation, and decreased mitochondrial stress, whereas lipid uptake was unaffected. These different findings in THP-1 MΦ and monocyte-derived MΦ could be attributed to the colony-forming growth pattern of THP-1 MΦ. At the lowest density, the distance to the closest neighboring cells showed greater influence on THP-1 MΦ than monocyte-derived MΦ. In addition, functional differences between monocyte-derived MΦ from different donors could at least partly be attributed to differences in culture density. Our findings demonstrate the importance of culture density for MΦ function and demand for awareness of culture density when conducting and interpreting in vitro experiments.
- Published
- 2023
- Full Text
- View/download PDF
32. Preventive Group Training Improves Children’s Outcomes after Divorce: A Dutch Quasi-experimental Study
- Author
-
Klein Velderman, Mariska, van Dommelen, Paula, Pannebakker, Fieke D., and Reijneveld, Sijmen A.
- Published
- 2022
- Full Text
- View/download PDF
33. Rates of spectacle wear in early childhood in the Netherlands
- Author
-
Iyer, Vasanthi, Enthoven, Clair A., van Dommelen, Paula, van Samkar, Ashwin, Groenewoud, Johanna H., Jaddoe, Vincent V. W., Reijneveld, Sijmen A., and Klaver, Caroline C. W.
- Published
- 2022
- Full Text
- View/download PDF
34. Use of machine learning to identify patients at risk of sub-optimal adherence: study based on real-world data from 10,929 children using a connected auto-injector device
- Author
-
Spataru, Amalia, van Dommelen, Paula, Arnaud, Lilian, Le Masne, Quentin, Quarteroni, Silvia, and Koledova, Ekaterina
- Published
- 2022
- Full Text
- View/download PDF
35. Hernieuwde evaluatie van de referentiewaarden van het Van Wiechenonderzoek
- Author
-
Deurloo, J. A., Huizing, A. H. J., van der Harst, S., de Wilde, J., van Dommelen, P., and Verkerk, P. H.
- Published
- 2021
- Full Text
- View/download PDF
36. Peiling melkvoeding van zuigelingen in 2018
- Author
-
van Dommelen, P. and Engelse, O.
- Published
- 2021
- Full Text
- View/download PDF
37. Curve matching to predict growth in patients receiving growth hormone therapy: An interpretable & explainable method
- Author
-
Paula van Dommelen, Lilian Arnaud, and Ekaterina Koledova
- Subjects
curve matching ,growth disorders ,growth hormone ,prediction model ,paediatric ,growth hormone deficiency ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Curve matching may be used to predict growth outcomes using data of patients whose growth curves resemble those of a new patient with growth hormone deficiency (GHD) and those born small for gestational age (SGA). We aimed to investigate the validity of curve matching to predict growth in patients with GHD and those born SGA receiving recombinant human growth hormone (r-hGH). Height data collected between 0–48 months of treatment were extracted from the easypod™ connect ecosystem and the easypod™ connect observational study. Selected patients with height standard deviation scores (HSDS) [-4,
- Published
- 2022
- Full Text
- View/download PDF
38. The Use of Galactomannan Antigen Assays for the Diagnosis of Invasive Pulmonary Aspergillosis in the Hematological Patient: A Systematic Review and Meta-Analysis
- Author
-
Lydia M. P. Bukkems, Laura van Dommelen, Marta Regis, Edwin van den Heuvel, and Laurens Nieuwenhuizen
- Subjects
invasive pulmonary aspergillosis ,galactomannan ,serum ,broncho-alveolar lavage ,hematology ,malignancy ,Biology (General) ,QH301-705.5 - Abstract
The optimal cut-off value of the optical density index of the galactomannan antigen assays (GM) for diagnosing invasive pulmonary aspergillosis in hematological patients is a disputed topic. This article conducts a systematic review with a meta-analysis to establish which optical density index (ODI) cut-off value should be implemented into clinical practice. Pubmed, Embase and Cochrane databases were searched (N = 27). The pooled data, using a generalized linear mixed model with binomial distribution, resulted in an overall serum sensitivity of 0.76 and a specificity of 0.92. For serum ODI 0.5 there was a pooled sensitivity of 0.92 and a specificity of 0.84. The pooled data of all broncho-alveolar lavage (BAL) studies resulted in an overall sensitivity of 0.80 and a specificity of 0.95. For BAL ODI 0.5, there was a pooled sensitivity of 0.75 and a specificity of 0.88. For the BAL ODI 1.0 pooling, the studies resulted in a sensitivity of 0.75 and a specificity of 0.96. Serum ODI of 0.5 and BAL ODI of 1.0 are the most suitable cut-offs for clinical practice. However, our study affirms that the evidence for the use of GM in clinical practice for the hematological malignancy patient is currently insufficient and more research is needed to determine the diagnostic value of GM.
- Published
- 2023
- Full Text
- View/download PDF
39. Integrated Digital Health Solutions in the Management of Growth Disorders in Pediatric Patients Receiving Growth Hormone Therapy: A Retrospective Analysis
- Author
-
Vincenzo Tornincasa, David Dixon, Quentin Le Masne, Blaine Martin, Lilian Arnaud, Paula van Dommelen, and Ekaterina Koledova
- Subjects
digital health ,growth hormone treatment ,pediatric endocrinology ,adherence monitoring ,patient engagement ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Digital health has seen rapid advancements over the last few years in helping patients and their healthcare professionals better manage treatment for a variety of illnesses, including growth hormone (GH) therapy for growth disorders in children and adolescents. For children and adolescents requiring such therapy, as well as for their parents, the treatment is longitudinal and often involves daily injections plus close progress monitoring; a sometimes daunting task when young children are involved. Here, we describe our experience in offering devices and digital health tools to support GH therapy across some 40 countries. We also discuss how this ecosystem of care has evolved over the years based on learnings and advances in technology. Finally, we offer a glimpse of future planned enhancements and directions for digital health to play a bigger role in better managing conditions treated with GH therapy, as well as model development for adherence prediction. The continued aim of these technologies is to improve clinical decision making and support for GH-treated patients, leading to better outcomes.
- Published
- 2022
- Full Text
- View/download PDF
40. Catch-up Growth in Prepubertal Children Treated for Juvenile Hypothyroidism and Growth Hormone Deficiency can be Modelled with a Monomolecular Function
- Author
-
Jan M. Wit, Theo C. J. Sas, Michael B. Rank, and Paula van Dommelen
- Subjects
growth ,catch-up growth ,coeliac disease ,growth hormone deficiency ,hypothyroidism ,Pediatrics ,RJ1-570 ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Objective:We hypothesized that modelling catch-up growth (CUG) as developed for coeliac disease (CD), might also fit CUG in adequately treated children with juvenile hypothyroidism (JHT) or growth hormone deficiency (GHD).Methods:We used a monomolecular function for all available prepubertal data on height standard deviation score (HSDS) minus target height SDS (adjHSDS) in children with JHT (n=20) and GHD (n=18) on a conventional (CoD) or high GH dose (HD), based either on a national height reference with an age cut-off of 10 (girls) and 12 (boys) years (model 1) or prepubertal height reference values, if age (0) was ≥3, with no upper age limit (model 2).Results:The models could be fitted in 83-90% of cases; in other cases the HSDS decreased after several measurements, which violated the assumption of an irreversible growth process. In JHT, the rate constant (k) and adjHSDS (0) were lower than in CD (p=0.02), but adjHSDS (end) was similar. In GHD (model 1), k was lower than for CD (p=0.004) but similar to JHT, while adjHSDS (0) and adjHSDS (end) were similar to CD and JHT. Thus, the shape of CUG is similar for children with JHT and GHD, while children with CD had less growth deficit at start and a faster CUG. The differences in CUG parameters between GH dose subgroups did not reach statistical significance.Conclusion:Modelling CUG of prepubertal children with JHT and GHD can be used for assessing the adequacy of CUG and the influence of clinical treatment modalities on its speed and magnitude.
- Published
- 2021
- Full Text
- View/download PDF
41. In hoeverre dragen de alarmsignalen uit de Jeugdgezondheidszorg-richtlijn Autismespectrumstoornissen bij aan de vroegsignalering van deze kinderen?
- Author
-
Bonnemaijer-Kerckhoffs, D. J. A., Wins, S. I., van Dommelen, P., and Verkerk, P. H.
- Published
- 2021
- Full Text
- View/download PDF
42. Maturation of the auditory system in normal-hearing newborns with a very or extremely premature birth
- Author
-
Paula van Dommelen, Karin de Graaff-Korf, Paul H. Verkerk, and Henrica L.M. van Straaten
- Subjects
neonatal hearing screening ,very preterm ,gestational age ,postmenstrual age ,Pediatrics ,RJ1-570 - Abstract
Background: Literature shows that lower gestational age leads to greater delays in the auditory conduction, which suggests atypical maturation of the brainstem in normal-hearing premature newborns. Our aim is to investigate if there is a difference between the extrauterine and intrauterine maturation of the auditory system in normal-hearing newborns with a very premature (28–31 weeks) or extremely premature (
- Published
- 2020
- Full Text
- View/download PDF
43. Analysis of real-world data on growth hormone therapy adherence using a connected injection device
- Author
-
Ekaterina Koledova, Vincenzo Tornincasa, and Paula van Dommelen
- Subjects
Adherence ,eHealth ,Electromechanical injection device ,Growth disorders ,Growth hormone ,Population health ,Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Abstract Background Poor adherence to long-term recombinant human growth hormone (r-hGH) treatment can lead to suboptimal clinical outcomes; consequently, supporting and monitoring adherence is a crucial part of patient management. We assessed adherence to r-hGH treatment in children with growth disorders over 48 months using a connected monitoring device (easypod™), which automatically transmits adherence data via an online portal (easypod™ connect); both sit within an adherence decision support system (ADSS). We also investigated the effect of age and sex on adherence. Methods Data from children transmitting over 10 injections between January 2007 and February 2019 were analyzed. Adherence (mg injected/mg prescribed) was categorized as high (≥85%), intermediate (> 56–84%) or low (≤56%) and assessed at seven time points from the start of treatment up to 48 months. Adherence was investigated over time and stratified by puberty status and sex. Mean transmission rate in each adherence category (total number of transmissions/total number of children) at each time point was calculated as a proxy measure of engagement in disease and treatment management. Descriptive analyses were performed. Results Longitudinal records were available for 13,553 children. Overall, 71% (n = 9578) had high adherence, 22% (n = 2989) intermediate and 7% (n = 986) low. The proportion of children with high adherence decreased over time from 87% (n = 12,964) to 65% (n = 957) and was higher in pre-pubertal than pubertal children (girls: 80% [n = 1270] vs 70% [n = 4496]; boys 79% [n = 2573] vs 65% [n = 5214]). Children with high adherence had a higher mean number of transmissions (12.5 [SD 24.9]) than children with intermediate (7.2 [SD 15.3]) or low (3.5 [SD 5.7]) adherence. Conclusions High adherence was seen in patients administering r-hGH using the connected device. Children with high adherence were most likely to regularly transmit data. Pubertal children showed lower adherence. We show the potential to develop an ADSS to analyze trends in real-world adherence data. This may prove useful to direct interventions to improve adherence while the ability to readily share data with healthcare professionals may itself improve adherence.
- Published
- 2020
- Full Text
- View/download PDF
44. Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia
- Author
-
Joseph H. Marcus, Cosimo Posth, Harald Ringbauer, Luca Lai, Robin Skeates, Carlo Sidore, Jessica Beckett, Anja Furtwängler, Anna Olivieri, Charleston W. K. Chiang, Hussein Al-Asadi, Kushal Dey, Tyler A. Joseph, Chi-Chun Liu, Clio Der Sarkissian, Rita Radzevičiūtė, Megan Michel, Maria Giuseppina Gradoli, Patrizia Marongiu, Salvatore Rubino, Vittorio Mazzarello, Daniela Rovina, Alessandra La Fragola, Rita Maria Serra, Pasquale Bandiera, Raffaella Bianucci, Elisa Pompianu, Clizia Murgia, Michele Guirguis, Rosana Pla Orquin, Noreen Tuross, Peter van Dommelen, Wolfgang Haak, David Reich, David Schlessinger, Francesco Cucca, Johannes Krause, and John Novembre
- Subjects
Science - Abstract
Ancient DNA analysis of early European farmers has found a high level of genetic affinity with present-day Sardinians. Here, the authors generate genome-wide capture data for 70 individuals from Sardinia spanning the Middle Neolithic to Medieval period to reveal relationships with mainland European populations shifting over time.
- Published
- 2020
- Full Text
- View/download PDF
45. Adherence to Growth Hormone Treatment Using a Connected Device in Latin America: Real-World Exploratory Descriptive Analysis Study
- Author
-
Aria Assefi, Paula van Dommelen, Lilian Arnaud, Carlos Otero, Luis Fernandez-Luque, Ekaterina Koledova, and Luis Eduardo Calliari
- Subjects
Information technology ,T58.5-58.64 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundRecombinant human growth hormone (rhGH) therapy is an effective treatment for children with growth disorders. However, poor outcomes are often associated with suboptimal adherence to treatment. ObjectiveThe easypod connected injection device records and transmits injection settings and dose data from patients receiving rhGH. In this study, we evaluated adherence to rhGH treatment, and associated growth outcomes, in Latin American patients. MethodsAdherence and growth data from patients aged 2-18 years from 12 Latin American countries were analyzed. Adherence data were available for 6207 patients with 2,449,879 injections, and growth data were available for 497 patients with 2232 measurements. Adherence was categorized, based on milligrams of rhGH injected versus milligrams of rhGH prescribed, as high (≥85%), intermediate (>56%-
- Published
- 2022
- Full Text
- View/download PDF
46. Development of a 3D Bioprinted Scaffold with Spatio-temporally Defined Patterns of BMP-2 and VEGF for the Regeneration of Large Bone Defects
- Author
-
Fiona Freeman, Pierluca Pitacco, Lieke van Dommelen, Jessica Nulty, David Browe, Jung- Shin, Eben Alsberg, and Daniel Kelly
- Subjects
Biology (General) ,QH301-705.5 - Abstract
The local delivery of growth factors such as BMP-2 is a well-established strategy for the repair of bone defects. The limitations of such approaches clinically are well documented and can be linked to the need for supraphysiological doses and poor spatio-temporal control of growth factor release in vivo. Using bioprinting techniques, it is possible to generate implants that can deliver cytokines or growth factors with distinct spatiotemporal release profiles and patterns to enhance bone regeneration. Specifically, for bone healing, several growth factors, including vascular endothelial growth factor (VEGF) and bone morphogenic proteins (BMPs), have been shown to be expressed at different phases of the process. This protocol aims to outline how to use bioprinting strategies to deliver growth factors, both alone or in combination, to the site of injury at physiologically relevant dosages such that repair is induced without adverse effects. Here we describe: the printing parameters to generate the polymer mechanical backbone; instructions to generate the different bioinks and allow for the temporal control of both growth factors; and the printing process to develop implants with spatially defined patterns of growth factors for bone regeneration. The novelty of this protocol is the use of multiple-tool fabrication techniques to develop an implant with spatio-temporal control of growth factor delivery for bone regeneration. While the overall aim of this protocol was to develop an implant for bone regeneration, the technique can be modified and used for a variety of regenerative purposes.Graphic abstract: 3D Bioprinting Spatio-Temporally Defined Patterns of Growth Factors to Tightly Control Bone Tissue Regeneration.
- Published
- 2021
- Full Text
- View/download PDF
47. Beknopt instrument om kinderen met een taalontwikkelingsstoornis tijdig te herkennen
- Author
-
Diepeveen, F. B., van Dommelen, P., Oudesluys-Murphy, A. M., and Verkerk, P. H.
- Published
- 2020
- Full Text
- View/download PDF
48. Homies with Aspirations and Positive Peer Network Ties: Associations with Reduced Frequent Substance Use among Gang-Affiliated Latino Youth
- Author
-
van Dommelen-Gonzalez, Evan, Deardorff, Julianna, Herd, Denise, and Minnis, Alexandra M
- Subjects
Behavioral and Social Science ,Pediatric ,Alcoholism ,Alcohol Use and Health ,Prevention ,Clinical Research ,Drug Abuse (NIDA only) ,Substance Misuse ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Prevention of disease and conditions ,and promotion of well-being ,Good Health and Well Being ,Adolescent ,Adolescent Behavior ,Alcoholism ,Female ,Hispanic or Latino ,Humans ,Juvenile Delinquency ,Male ,Marijuana Abuse ,Peer Group ,Risk Factors ,San Francisco ,Sexual Behavior ,Social Determinants of Health ,Socioeconomic Factors ,Substance-Related Disorders ,Urban Health ,Young Adult ,Latino youth ,Gangs ,Social networks ,Substance use ,Positive deviance ,Human Movement and Sports Sciences ,Public Health and Health Services ,Public Health - Abstract
In marginalized urban neighborhoods across the USA, Latino youth are disproportionately represented among the growing number of youth gangs. Substance use among gang-involved youth poses both immediate and long-term health risks and can threaten educational engagement, future socioeconomic stability, and desistance. Conventional assessments of gang-affiliated youth and their peer network overlook the possibility that positive peer ties may exist and can foster health promoting behavior norms. Drawing on a positive deviance framework, in this study, we examine the relationship between positive peer network characteristics tied to post-secondary educational aspirations and frequent alcohol and marijuana use among Latino, gang-affiliated youth from a neighborhood in San Francisco. Using generalized estimating equations regression models across 72 peer network clusters (162 youth), we found that having close friends who plan to go to a 4-year college was associated with a lower odds of frequent marijuana and alcohol use (OR 0.27, p = 0.02; OR 0.29, p = 0.14, respectively) and that this association persisted when adjusting for risk characteristics (OR 0.19, p
- Published
- 2015
49. Description of a Differential Setup for Relaxation Microcalorimetry
- Author
-
Leitao, J. V., van Dommelen, P., Naastepad, F., and Brück, E.
- Subjects
Physics - Instrumentation and Detectors ,Condensed Matter - Materials Science - Abstract
A specific heat measuring instrument, with the capacity for the application of magnetic fields up to 9 Tesla, resorting to microcalorimetry chips from the company Xensor Integration, has been successfully assembled and its functioning specifications are reported in the current paper. With this instrument is it possible to perform specific heat measurements with applied magnetic fields up to 9 Tesla in milligram samples. This offers our group the possibility to calculate the actual adiabatic temperature change of a material, as well as providing reliable and precise information on any phase transition that may be influenced by the application of a magnetic field., Comment: Previously published in the proceedings of Thermag V and currently submitted for a Special Issue of the International Journal of Refrigeration
- Published
- 2013
50. Multi-scale fracture probability analysis of tungsten monoblocks under fusion conditions
- Author
-
M.A. Oude Vrielink, J.A.W. van Dommelen, and M.G.D. Geers
- Subjects
Crystal plasticity ,Tungsten ,Nuclear fusion ,Failure probability ,Neutron irradiation ,Cluster dynamics ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
Plasma facing components inside future nuclear fusion reactors are subjected to a high heat load and intense irradiation conditions. Using advanced computational material models, several problems can be solved that reflect tungsten monoblocks under fusion relevant loading scenarios. This allows for the identification of the conditions under which material failure is probable. The material model and parameters are identified such that the mechanical behaviour is in accordance with the homogenized behaviour of a previously developed crystal plasticity model on the microscopic scale. The heterogeneous stress field that follows is analysed in order to assess the probability of material failure, which is typically reflected by unstable crack propagation. Since fracture is an inherently multi-scale problem, critical regions are analysed in detail by means of a representative volume element. The resulting analysis reveals that in case the stress relaxation in the monoblock under the applied static heat load is complete, the probability of unstable crack propagation can reach values close to 35%. Finally, the impact of prolonged neutron irradiation is simulated by means of a cluster dynamics model. Although irradiation drastically increases the brittleness of tungsten, its impact on the overall monoblock performance remains limited.
- Published
- 2021
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.