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10. Three Key Questions On Responsible Tax Policy

Author

Van Dijk, Peter

Subjects
Corporate governance, Tax policy -- Laws, regulations and rules, Corporate social responsibility, Corporate sustainability, Tax administration and procedure -- Laws, regulations and rules, Government regulation, Business, international
Abstract

A responsible tax policy has become a key component of a company's Environmental, Social, and Governance (ESG) strategy. This article addresses three key questions about responsible tax policy. What are [...]

Published
2024

18. Characterizing the Impact of Physical Activity on Patients with Type 1 Diabetes Using Statistical and Machine Learning Models.

Author

Chushig-Muzo, David, Calero-Díaz, Hugo, Fabelo, Himar, Årsand, Eirik, van Dijk, Peter Ruben, and Soguero-Ruiz, Cristina

Subjects
CONTINUOUS glucose monitoring, MACHINE learning, BLOOD sugar monitors, TYPE 1 diabetes, GLYCEMIC control
Abstract

Continuous glucose monitoring (CGM) represents a significant advancement in diabetes management, playing an important role in glycemic control for patients with type 1 diabetes (T1D). Despite their benefits, their performance is affected by numerous factors such as the carbohydrate intake, alcohol consumption, and physical activity (PA). Among these, PA could cause hypoglycemic episodes, which might happen after exercising. In this work, two main contributions are presented. First, we extend the performance evaluation of two glucose monitoring devices, Eversense and Free Style Libre (FSL), for measuring glucose concentrations during high-intensity PA and normal daily activity (NDA). The impact of PA is investigated considering (1) different glucose ranges (hypoglycemia, euglycemia, and hyperglycemia); and (2) four time periods throughout the day (morning, afternoon, evening, and night). Second, we evaluate the effectiveness of machine learning (ML) models, including logistic regression, K-nearest neighbors, and support vector machine, to automatically detect PA in T1D individuals using glucose measurements. The performance analysis showed significant differences between glucose levels obtained in the PA and NDA period for Eversense and FSL devices, specially in the hyperglycemic range and two time intervals (morning and afternoon). Both Eversense and FSL devices present measurements with large variability during strenuous PA, indicating that their users should be cautious. However, glucose recordings provided by monitoring devices are accurate for NDA, reaching similar values to capillary glucose device. Lastly, ML-based models yielded promising results to determine when an individual has performed PA, reaching an accuracy value of 0.93. The results can be used to develop an individualized data-driven classifier for each patient that categorizes glucose profiles based on the time interval during the day and according to if a patient performs PA. Our work contributes to the analysis of PA on the performance of CGM devices. [ABSTRACT FROM AUTHOR]

Published
2024
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19. A PARTHENOGENESIS allele from apomictic dandelion can induce egg cell division without fertilization in lettuce

Author

Underwood, Charles J., Vijverberg, Kitty, Rigola, Diana, Okamoto, Shunsuke, Oplaat, Carla, Camp, Rik H. M. Op den, Radoeva, Tatyana, Schauer, Stephen E., Fierens, Joke, Jansen, Kim, Mansveld, Sandra, Busscher, Marco, Xiong, Wei, Datema, Erwin, Nijbroek, Koen, Blom, Evert-Jan, Bicknell, Ross, Catanach, Andrew, Erasmuson, Sylvia, Winefield, Christopher, van Tunen, Arjen J., Prins, Marcel, Schranz, M. Eric, and van Dijk, Peter J.

Published
2022
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25. Taxonomy based on science is necessary for global conservation.

Author

Thomson, Scott A, Pyle, Richard L, Ahyong, Shane T, Alonso-Zarazaga, Miguel, Ammirati, Joe, Araya, Juan Francisco, Ascher, John S, Audisio, Tracy Lynn, Azevedo-Santos, Valter M, Bailly, Nicolas, Baker, William J, Balke, Michael, Barclay, Maxwell VL, Barrett, Russell L, Benine, Ricardo C, Bickerstaff, James RM, Bouchard, Patrice, Bour, Roger, Bourgoin, Thierry, Boyko, Christopher B, Breure, Abraham SH, Brothers, Denis J, Byng, James W, Campbell, David, Ceríaco, Luis MP, Cernák, István, Cerretti, Pierfilippo, Chang, Chih-Han, Cho, Soowon, Copus, Joshua M, Costello, Mark J, Cseh, Andras, Csuzdi, Csaba, Culham, Alastair, D'Elía, Guillermo, d'Udekem d'Acoz, Cédric, Daneliya, Mikhail E, Dekker, René, Dickinson, Edward C, Dickinson, Timothy A, van Dijk, Peter Paul, Dijkstra, Klaas-Douwe B, Dima, Bálint, Dmitriev, Dmitry A, Duistermaat, Leni, Dumbacher, John P, Eiserhardt, Wolf L, Ekrem, Torbjørn, Evenhuis, Neal L, Faille, Arnaud, Fernández-Triana, José L, Fiesler, Emile, Fishbein, Mark, Fordham, Barry G, Freitas, André VL, Friol, Natália R, Fritz, Uwe, Frøslev, Tobias, Funk, Vicki A, Gaimari, Stephen D, Garbino, Guilherme ST, Garraffoni, André RS, Geml, József, Gill, Anthony C, Gray, Alan, Grazziotin, Felipe G, Greenslade, Penelope, Gutiérrez, Eliécer E, Harvey, Mark S, Hazevoet, Cornelis J, He, Kai, He, Xiaolan, Helfer, Stephan, Helgen, Kristofer M, van Heteren, Anneke H, Hita Garcia, Francisco, Holstein, Norbert, Horváth, Margit K, Hovenkamp, Peter H, Hwang, Wei Song, Hyvönen, Jaakko, Islam, Melissa B, Iverson, John B, Ivie, Michael A, Jaafar, Zeehan, Jackson, Morgan D, Jayat, J Pablo, Johnson, Norman F, Kaiser, Hinrich, Klitgård, Bente B, Knapp, Dániel G, Kojima, Jun-Ichi, Kõljalg, Urmas, Kontschán, Jenő, Krell, Frank-Thorsten, Krisai-Greilhuber, Irmgard, Kullander, Sven, Latella, Leonardo, Lattke, John E, and Lencioni, Valeria

Subjects
Conservation of Natural Resources, Biodiversity, Biological Sciences, Medical And Health Sciences, Agricultural And Veterinary Sciences, Developmental Biology, Medical and Health Sciences, Agricultural and Veterinary Sciences
Published
2018

27. Serum T50 predicts cardiovascular mortality in individuals with type 2 diabetes: A prospective cohort study

Author

van der Vaart, Amarens, primary, Eelderink, Coby, additional, van Goor, Harry, additional, Hillebrands, Jan‐Luuk, additional, te Velde‐Keyzer, Charlotte A., additional, Bakker, Stephan J.L., additional, Pasch, Andreas, additional, van Dijk, Peter R., additional, Laverman, Gozewijn D., additional, and de Borst, Martin H., additional

Published
2024
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30. HbA1cand fasting plasma glucose levels are equally related to incident cardiovascular risk in a high CVD risk population without known diabetes

Author

Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Been, Riemer A., Noordstar, Ellen, Helmink, Marga A.G., Van Sloten, Thomas T., De Ranitz-Greven, Wendela L., Van Beek, André P., Houweling, Sebastiaan T., Van Dijk, Peter R., Westerink, Jan, Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Been, Riemer A., Noordstar, Ellen, Helmink, Marga A.G., Van Sloten, Thomas T., De Ranitz-Greven, Wendela L., Van Beek, André P., Houweling, Sebastiaan T., Van Dijk, Peter R., and Westerink, Jan

Published
2024

31. Cohort profile:the 'Biomarkers of heterogeneity in type 1 diabetes' study-a national prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes in the Netherlands

Author

Aanstoot, Henk Jan, Varkevisser, Rita D.M., Mul, Dick, Dekker, Pim, Birnie, Erwin, Boesten, Lianne S.M., Brugts, Michael P., van Dijk, Peter R., Duijvestijn, Petronella H.L.M., Dutta, Sanjoy, Fransman, Christine, Gonera, Rob K., Hoogenberg, Klaas, Kooy, Adriaan, Latres, Esther, Loves, Sandra, Nefs, Giesje, Sas, Theo, Vollenbrock, Charlotte E., Vosjan-Noeverman, Marleen J., de Vries-Velraeds, Martine M.C., Veeze, Henk J., Wolffenbuttel, Bruce H.R., van der Klauw, Melanie M., Aanstoot, Henk Jan, Varkevisser, Rita D.M., Mul, Dick, Dekker, Pim, Birnie, Erwin, Boesten, Lianne S.M., Brugts, Michael P., van Dijk, Peter R., Duijvestijn, Petronella H.L.M., Dutta, Sanjoy, Fransman, Christine, Gonera, Rob K., Hoogenberg, Klaas, Kooy, Adriaan, Latres, Esther, Loves, Sandra, Nefs, Giesje, Sas, Theo, Vollenbrock, Charlotte E., Vosjan-Noeverman, Marleen J., de Vries-Velraeds, Martine M.C., Veeze, Henk J., Wolffenbuttel, Bruce H.R., and van der Klauw, Melanie M.

Abstract

PURPOSE: The 'Biomarkers of heterogeneity in type 1 diabetes' study cohort was set up to identify genetic, physiological and psychosocial factors explaining the observed heterogeneity in disease progression and the development of complications in people with long-standing type 1 diabetes (T1D). PARTICIPANTS: Data and samples were collected in two subsets. A prospective cohort of 611 participants aged ≥16 years with ≥5 years T1D duration from four Dutch Diabetes clinics between 2016 and 2021 (median age 32 years; median diabetes duration 12 years; 59% female; mean glycated haemoglobin (HbA1c) 61 mmol/mol (7.7%); 61% on insulin pump; 23% on continuous glucose monitoring (CGM)). Physical assessments were performed, blood and urine samples were collected, and participants completed questionnaires. A subgroup of participants underwent mixed-meal tolerance tests (MMTTs) at baseline (n=169) and at 1-year follow-up (n=104). Genetic data and linkage to medical and administrative records were also available. A second cross-sectional cohort included participants with ≥35 years of T1D duration (currently n=160; median age 64 years; median diabetes duration 45 years; 45% female; mean HbA1c 58 mmol/mol (7.4%); 51% on insulin pump; 83% on CGM), recruited from five centres and measurements, samples and 5-year retrospective data were collected. FINDINGS TO DATE: Stimulated residual C-peptide was detectable in an additional 10% of individuals compared with fasting residual C-peptide secretion. MMTT measurements at 90 min and 120 min showed good concordance with the MMTT total area under the curve. An overall decrease of C-peptide at 1-year follow-up was observed. Fasting residual C-peptide secretion is associated with a decreased risk of impaired awareness of hypoglycaemia. FUTURE PLANS:Research groups are invited to consider the use of these data and the sample collection. Future work will include additi

Published
2024

32. HbA1c and fasting plasma glucose levels are equally related to incident cardiovascular risk in a high CVD risk population without known diabetes.

Author

Been, Riemer A., Noordstar, Ellen, Helmink, Marga A.G., van Sloten, Thomas T., de Ranitz-Greven, Wendela L., van Beek, André P., Houweling, Sebastiaan T., van Dijk, Peter R., and Westerink, Jan

Subjects
TYPE 2 diabetes, BLOOD sugar, MEDICAL screening, CARDIOVASCULAR diseases, DIABETES
Abstract

Type 2 diabetes (T2DM) is associated with increased risk for cardiovascular disease (CVD). Whether screen-detected T2DM, based on fasting plasma glucose (FPG) or on HbA1c, are associated with different risks of incident CVD in high-risk populations and which one is preferable for diabetes screening in these populations, remains unclear. A total of 8,274 high-risk CVD participants were included from the UCC-SMART cohort. Participants were divided into groups based on prior T2DM diagnosis, and combinations of elevated/non-elevated FPG and HbA1c (cut-offs at 7 mmol/L and 48 mmol/mol, respectively): Group 0: known T2DM; group 1: elevated FPG/HbA1c; group 2: elevated FPG, non-elevated HbA1c; group 3: non-elevated FPG, elevated HbA1c; group 1 + 2: elevated FPG, regardless of HbA1c; group 1 + 3: elevated HbA1c, regardless of FPG; and group 4 (reference), non-elevated FPG/HbA1c. During a median follow-up of 6.3 years (IQR 3.3–9.8), 712 cardiovascular events occurred. Compared to the reference (group 4), group 0 was at increased risk (HR 1.40; 95 % CI 1.16–1.68), but group 1 (HR 1.16; 95 % CI 0.62–2.18), 2 (HR 1.18; 95 % CI 0.84–1.67), 3 (HR 0.61; 95 % CI 0.15–2.44), 1 + 2 (HR 1.17; 95 % CI 0.86–1.59) and 1 + 3 (HR 1.01; 95 % CI 0.57–1.79) were not. However, spline interpolation showed a linearly increasing risk with increasing HbA1c/FPG, but did not allow for identification of other cut-off points. Based on current cut-offs, FPG and HbA1c at screening were equally related to incident CVD in high-risk populations without known T2DM. Hence, neither FPG, nor HbA1c, is preferential for diabetes screening in this population with respect to risk of incident CVD. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Serum T50 predicts cardiovascular mortality in individuals with type 2 diabetes: A prospective cohort study.

Author

van der Vaart, Amarens, Eelderink, Coby, van Goor, Harry, Hillebrands, Jan‐Luuk, te Velde‐Keyzer, Charlotte A., Bakker, Stephan J.L., Pasch, Andreas, van Dijk, Peter R., Laverman, Gozewijn D., and de Borst, Martin H.

Subjects
TYPE 2 diabetes, COHORT analysis, LONGITUDINAL method, MORTALITY, GLOMERULAR filtration rate
Abstract

Background and aims: Individuals with type 2 diabetes (T2D) have a higher risk of cardiovascular disease, compared with those without T2D. The serum T50 test captures the transformation time of calciprotein particles in serum. We aimed to assess whether serum T50 predicts cardiovascular mortality in T2D patients, independent of traditional risk factors. Methods: We analyzed 621 individuals with T2D in this prospective cohort study. Cox regression models were performed to test the association between serum T50 and cardiovascular and all‐cause mortality. Causes of death were categorized according to ICD‐10 codes. Risk prediction improvement was assessed by comparing Harrell's C for models without and with T50. Results: The mean age was 64.2 ± 9.8 years, and 61% were male. The average serum T50 time was 323 ± 63 min. Higher age, alcohol use, high‐sensitive C‐reactive protein, and plasma phosphate were associated with lower serum T50 levels. Higher plasma triglycerides, venous bicarbonate, sodium, magnesium, and alanine aminotransferase were associated with higher serum T50 levels. After a follow‐up of 7.5[5.4–10.7] years, each 60 min decrease in serum T50 was associated with an increased risk of cardiovascular (fully adjusted HR 1.32, 95% CI 1.08–1.50, and p = 0.01) and all‐cause mortality (HR 1.15, 95%CI 1.00–1.38, and p = 0.04). Results were consistent in sensitivity analyses after exclusion of individuals with estimated glomerular filtration rate <45 or <60 mL/min/1.73 m2 and higher plasma phosphate levels. Conclusions: Serum T50 improves prediction of cardiovascular and all‐cause mortality risk in individuals with T2D. Serum T50 may be useful for risk stratification and to guide therapeutic strategies aiming to reduce cardiovascular mortality in T2D. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Widespread support for a global species list with a formal governance system

Author

Lien, Aaron M., primary, Banki, Olaf, additional, Barik, Saroj K., additional, Buckeridge, John S., additional, Christidis, Les, additional, Cigliano, María Marta, additional, Conix, Stijn, additional, Costello, Mark John, additional, Hobern, Donald, additional, Kirk, Paul M., additional, Kroh, Andreas, additional, Montgomery, Narelle, additional, Nikolaeva, Svetlana, additional, Orrell, Thomas M., additional, Pyle, Richard L., additional, Raz, Lauren, additional, Thiele, Kevin, additional, Thomson, Scott A., additional, van Dijk, Peter Paul, additional, Wambiji, Nina, additional, Whalen, Anthony, additional, Zachos, Frank E., additional, Zhang, Zhi-Qiang, additional, and Garnett, Stephen T., additional

Published
2023
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46. Cohort profile: the "Biomarkers of heterogeneity in type 1 diabetes" study - a prospective cohort study of clinical and metabolic phenotyping of individuals with long-standing type 1 diabetes

Author

Mul, Dick, primary, Varkevisser, Rita D.M., additional, Aanstoot, Henk-Jan, additional, Dekker, Pim, additional, Birnie, Erwin, additional, Boersma, Erik, additional, Boesten, Lianne S.M., additional, Brugts, Michael P., additional, van Dijk, Peter R., additional, Duijvestijn, Petronella H.L.M., additional, Dutta, Sanjoy, additional, Fransman, Christine, additional, Gonera, Rob, additional, Hoogenberg, Klaas, additional, Kooy, Adriaan, additional, Latres, Esther, additional, Loves, Sandra, additional, Nefs, Giesje, additional, Sas, Theo, additional, Verburg, Frederik A.J., additional, Vollenbrock, Charlotte E., additional, Vosjan-Noeverman, Marleen J., additional, de Vries-Velraeds, Martine M.C., additional, Veeze, Henk J., additional, Wolffenbuttel, Bruce H.R., additional, and van der Klauw, Melanie M., additional

Published
2023
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