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1. The Current State of Robot-Assisted Minimally Invasive Esophagectomy (RAMIE): Outcomes from the Upper GI International Robotic Association (UGIRA) Esophageal Registry

Author

Kooij, Cezanne D., de Jongh, Cas, Kingma, B. Feike, van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Chao, Yin-Kai, Chiu, Philip W., Rouanet, Philippe, Mourregot, Anne, Immanuel, Arul, Mala, Tom, van Boxel, Gijs I., Carter, Nicholas C., Li, Hecheng, Fuchs, Hans F., Bruns, Christiane J., Giacopuzzi, Simone, Kalff, Jörg C., Hölzen, Jens-Peter, Juratli, Mazen A., Benedix, Frank, Lorenz, Eric, Egberts, Jan-Hendrik, Haveman, Jan W., van Etten, Boudewijn, Müller, Beat P., Grimminger, Peter P., Berlth, Felix, Piessen, Guillaume, van den Berg, Jan W., Milone, Marco, Luketich, James D., Sarkaria, Inderpal S., Sallum, Rubens A. A., van Det, Marc J., Kouwenhoven, Ewout A., Brüwer, Matthias, Harustiak, Tomas, Kinoshita, Takahiro, Fujita, Takeo, Daiko, Hiroyuki, Li, Zhigang, Ruurda, Jelle P., and van Hillegersberg, Richard

Published
2024
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2. Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer: A Cost Analysis in the Prospective Multicenter PLASTIC-Study

Author

de Jongh, Cas, van der Meulen, Miriam P., Gertsen, Emma C., Brenkman, Hylke J. F., van Sandick, Johanna W., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., van Lanschot, Jan J. B., Lagarde, Sjoerd M., Wijnhoven, Bas P. L., de Steur, Wobbe O., Hartgrink, Henk H., Stoot, Jan H. M. B., Hulsewe, Karel W. E., Spillenaar Bilgen, Ernst Jan, van Det, Marc J., Kouwenhoven, Ewout A., Daams, Freek, van der Peet, Donald L., van Grieken, Nicole C. T., Heisterkamp, Joos, van Etten, Boudewijn, van den Berg, Jan-Willem, Pierie, Jean-Pierre, Eker, Hasan H., Thijssen, Annemieke Y., Belt, Eric J. T., van Duijvendijk, Peter, Wassenaar, Eelco, Wevers, Kevin P., Hol, Lieke, Wessels, Frank J., Haj Mohammad, Nadia, Frederix, Geert W. J., van Hillegersberg, Richard, Siersema, Peter D., Vegt, Erik, and Ruurda, Jelle P.

Published
2024
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5. Surgical Techniques and Related Perioperative Outcomes After Robot-assisted Minimally Invasive Gastrectomy (RAMIG): Results From the Prospective Multicenter International Ugira Gastric Registry

Author

de Jongh, Cas, Cianchi, Fabio, Kinoshita, Takahiro, Kingma, Feike, Piccoli, Micaela, Dubecz, Attila, Kouwenhoven, Ewout, van Det, Marc, Mala, Tom, Coratti, Andrea, Ubiali, Paolo, Turner, Paul, Kish, Pursnani, Borghi, Felice, Immanuel, Arul, Nilsson, Magnus, Rouvelas, Ioannis, Holzen, Jens P., Rouanet, Philippe, Saint-Marc, Olivier, Dussart, David, Patriti, Alberto, Bazzocchi, Francesca, van Etten, Boudewijn, Haveman, Jan W., DePrizio, Marco, Sabino, Flávio, Viola, Massimo, Berlth, Felix, Grimminger, Peter P., Roviello, Franco, van Hillegersberg, Richard, Ruurda, Jelle, Barbato, Giuseppe, Takeuchi, Tamae, Yura, Masahiro, Pecchini, Francesca, Mullineris, Barbara, Kemeter, Melissa, Giulini, Luca, Førland, Dag, Di Marino, Michele, Tribuzi, Angela, Maffeis, Federica, Velkoski, Jaqueline, Sarantitis, Ioannis, Marano, Alessandra, Robella, Manuela, Jaretzke, Helen, Ri, Motonari, Juratli, Mazen, Mourregot, Anne, Petrelli, Filippo, Biancafarina, Alessia, Barbieri, Vittoria, Uzun, Eren, Marano, Luigi, d’Ignazio, Alessia, and Resca, Luca

Published
2024
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8. The Comprehensive Complication Index versus Clavien-Dindo grading after laparoscopic and open D2-gastrectomy in the multicenter randomized LOGICA-trial

Author

Brenkman, Hylke J.F., van der Veen, Arjen, Nieuwenhuijzen, Grard A.P., Ponten, Jeroen E.H., Tegels, Juul J.W., Hulsewe, Karel W.E., Wijnhoven, Bas P.L., Lanschot, Jan J.B., de Steur, Wobbe O., Hartgrink, Henk H., Kouwenhoven, Ewout A., van Det, Marc J., Wassenaar, Eelco B., van Duijvendijk, P., Draaisma, Werner A., Broeders, Ivo A.M.J., van der Peet, Donald L., Gisbertz, Suzanne S., Triemstra, Lianne, de Jongh, Cas, Tedone, Fabrizio, Brosens, Lodewijk A.A., Luyer, Misha D.P., Stoot, Jan H.M.B., Lagarde, Sjoerd M., van Hillegersberg, Richard, and Ruurda, Jelle P.

Published
2023
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9. Surgical quality and prospective quality control of the D2-gastrectomy for gastric cancer in the multicenter randomized LOGICA-trial

Author

Brenkman, Hylke JF., Seesing, Maarten F.J., Luyer, Misha DP., Ponten, Jeroen EH., Tegels, Juul JW., Hulsewe, Karel WE., Hartgrink, Henk H., Wijnhoven, Bas PL., Lagarde, Sjoerd M., Kouwenhoven, Ewout A., van Det, Marc J., Wassenaar, Eelco B., van Duijvendijk, P., Draaisma, Werner A., Broeders, Ivo AMJ., van der Peet, Donald L., Gisbertz, Suzanne S., de Jongh, Cas, Triemstra, Lianne, van der Veen, Arjen, Brosens, Lodewijk AA., Nieuwenhuijzen, Grard AP., Stoot, Jan HMB., de Steur, Wobbe O., Ruurda, Jelle P., and van Hillegersberg, Richard

Published
2023
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10. Hybrid laparoscopic versus fully robot-assisted minimally invasive esophagectomy: an international propensity-score matched analysis of perioperative outcome

Author

Jung, Jin-On, de Groot, Eline M., Kingma, B. Feike, Babic, Benjamin, Ruurda, Jelle P., Grimminger, Peter P., Hölzen, Jens P., Chao, Yin-Kai, Haveman, Jan W., van Det, Marc J., Rouanet, Philippe, Benedix, Frank, Li, Hecheng, Sarkaria, Inderpal, van Berge Henegouwen, Mark I., van Boxel, Gijs I., Chiu, Philip, Egberts, Jan-Hendrik, Sallum, Rubens, Immanuel, Arul, Turner, Paul, Low, Donald E., Hubka, Michal, Perez, Daniel, Strignano, Paolo, Biebl, Matthias, Chaudry, M. Asif, Bruns, Christiane J., van Hillegersberg, Richard, and Fuchs, Hans F.

Published
2023
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11. Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue

Author

Ubels, Sander, Matthée, Eric, Verstegen, Moniek, Klarenbeek, Bastiaan, Bouwense, Stefan, van Berge Henegouwen, Mark I., Daams, Freek, Dekker, Jan Willem T., van Det, Marc J., van Esser, Stijn, Griffiths, Ewen A., Haveman, Jan Willem, Nieuwenhuijzen, Grard, Siersema, Peter D., Wijnhoven, Bas, Hannink, Gerjon, van Workum, Frans, and Rosman, Camiel

Published
2023
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13. Body Composition Is a Predictor for Postoperative Complications After Gastrectomy for Gastric Cancer: a Prospective Side Study of the LOGICA Trial

Author

Tweed, Thaís T. T., van der Veen, Arjen, Tummers, Stan, van Dijk, David P. J., Luyer, Misha D. P., Ruurda, Jelle P., van Hillegersberg, Richard, Stoot, Jan H. M. B., Tegels, Juul J. W., Hulsewe, Karel W. E., Brenkman, Hylke J. F., Seesing, Maarten F. J., Nieuwenhuijzen, Grard A. P., Ponten, Jeroen E. H., Wijnhoven, Bas P. L., Lagarde, Sjoerd M., de Steur, Wobbe O., Hartgrink, Henk H., Kouwenhoven, Ewout A., van Det, Marc J., Wassenaar, Eelco B., van der Zaag, Edwin S., Draaisma, Werner A., Broeders, Ivo A. M. J., Gisbertz, Suzanne S., van Berge Henegouwen, Mark I., and van Laarhoven, Hanneke W. M.

Published
2022
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14. Learning Curve of Laparoscopic Gastrectomy: A Multicenter Study

Author

Brenkman, Hylke J.F., Claassen, Linda, Hannink, Gerjon, van der Werf, Leonie R., Ruurda, Jelle P.-H., Nieuwenhuizen, Grard A.P., Luyer, Misha D.P., Kouwenhoven, Ewout A., van Det, Marc J., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Stoot, Jan H.M.B., Hulsewé, Karel W.E., van Workum, Frans, van Hillegersberg, Richard, and Rosman, Camiel

Published
2023
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15. Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., van Berge Henegouwen, Mark I., Baas, Peter C., Bahadoer, Renu R., Belt, Eric J. T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J., van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P. R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, E. G. J. M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A. M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B. A. C., Stoop, Fanny J., Voeten, Daan M., Vugts, Guusje, Vijgen, Guy H. E. J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G. H., and Gisbertz, Suzanne S.

Published
2023
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16. Peroperative administration of tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce haemorrhage in patients with morbid obesity: protocol for randomised controlled trial (PATRY trial)

Author

't Hart, Judith W H, primary, Noordman, Bo J, additional, Palsgraaf-Huisbrink, Jeannine, additional, Dunkelgrun, Martin, additional, Zengerink, Hans F, additional, Birnie, Erwin, additional, van Det, Marc J, additional, Boerma, Evert-Jan G, additional, de Castro, Steve M M, additional, Hazebroek, Eric J, additional, Langenhoff, Barbara S, additional, Verhoef, Cornelis, additional, and Apers, Jan A, additional

Published
2024
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18. Postoperative intensive care unit stay after minimally invasive esophagectomy shows large hospital variation. Results from the Dutch Upper Gastrointestinal Cancer Audit

Author

van Det, Marc J., van Duijvendijk, Peter, van Esser, Stijn, van Etten, Boudewijn, van der Harst, Erwin, Hartgrink, Henk H., Heisterkamp, Joos, Nieuwenhuijzen, Grard A.P., van der Peet, Donald L., Pierie, Jean-Pierre E.N., Rosman, Camiel, van Sandick, Johanna W., Sosef, Meindert N., Wijnhoven, Bas P.L., Voeten, Daan M., van der Werf, Leonie R., Gisbertz, Suzanne S., Ruurda, Jelle P., van Berge Henegouwen, Mark I., and van Hillegersberg, Richard

Published
2021
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19. Learning Curve of Laparoscopic Gastrectomy: A Multicenter Study

Author

Brenkman, Hylke J.F., Claassen, Linda, Hannink, Gerjon, van der Werf, Leonie R., Ruurda, Jelle P.-H., Nieuwenhuizen, Grard A.P., Luyer, Misha D.P., Kouwenhoven, Ewout A., van Det, Marc J., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Stoot, Jan H.M.B., Hulsewé, Karel W.E., van Workum, Frans, van Hillegersberg, Richard, and Rosman, Camiel

Published
2022
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20. The impact of hospital experience in bariatric surgery on short-term outcomes after minimally invasive esophagectomy: a nationwide analysis

Author

MS CGO, Cancer, Janssen, Henricus J B, Geraedts, Tessa C M, Simkens, Geert A, Visser, Maurits, de Hingh, Ignace H J T, van Det, Marc J, Nieuwenhuijzen, Grard A P, van Hillegersberg, Richard, Luyer, Misha D P, Nienhuijs, Simon W, MS CGO, Cancer, Janssen, Henricus J B, Geraedts, Tessa C M, Simkens, Geert A, Visser, Maurits, de Hingh, Ignace H J T, van Det, Marc J, Nieuwenhuijzen, Grard A P, van Hillegersberg, Richard, Luyer, Misha D P, and Nienhuijs, Simon W

Published
2024

21. Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer:A Cost Analysis in the Prospective Multicenter PLASTIC-Study

Author

de Jongh, Cas, Gertsen, Emma C., van der Meulen, Miriam P., Brenkman, Hylke J.F., van Sandick, Johanna W., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., van Lanschot, Jan J.B., Lagarde, Sjoerd M., Wijnhoven, Bas P.L., de Steur, Wobbe O., Hartgrink, Henk H., Stoot, Jan H.M.B., Hulsewe, Karel W.E., Spillenaar Bilgen, Ernst Jan, van Det, Marc J., Kouwenhoven, Ewout A., Daams, Freek, van der Peet, Donald L., van Grieken, Nicole C.T., Heisterkamp, Joos, van Etten, Boudewijn, van den Berg, Jan Willem, Pierie, Jean Pierre, Eker, Hasan H., Thijssen, Annemieke Y., Belt, Eric J.T., van Duijvendijk, Peter, Wassenaar, Eelco, Wevers, Kevin P., Hol, Lieke, Wessels, Frank J., Haj Mohammad, Nadia, Frederix, Geert W.J., van Hillegersberg, Richard, Siersema, Peter D., Vegt, Erik, Ruurda, Jelle P., de Jongh, Cas, Gertsen, Emma C., van der Meulen, Miriam P., Brenkman, Hylke J.F., van Sandick, Johanna W., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., van Lanschot, Jan J.B., Lagarde, Sjoerd M., Wijnhoven, Bas P.L., de Steur, Wobbe O., Hartgrink, Henk H., Stoot, Jan H.M.B., Hulsewe, Karel W.E., Spillenaar Bilgen, Ernst Jan, van Det, Marc J., Kouwenhoven, Ewout A., Daams, Freek, van der Peet, Donald L., van Grieken, Nicole C.T., Heisterkamp, Joos, van Etten, Boudewijn, van den Berg, Jan Willem, Pierie, Jean Pierre, Eker, Hasan H., Thijssen, Annemieke Y., Belt, Eric J.T., van Duijvendijk, Peter, Wassenaar, Eelco, Wevers, Kevin P., Hol, Lieke, Wessels, Frank J., Haj Mohammad, Nadia, Frederix, Geert W.J., van Hillegersberg, Richard, Siersema, Peter D., Vegt, Erik, and Ruurda, Jelle P.

Abstract

Background: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. Materials and Methods:In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18FFDG-PET/CT first, then SL, (2) SL only, (3) 18FFDG-PET/CT only, and (4) neither SL nor 18FFDG-PET/CT. Costs were assessed on the basis of the prospective PLASTIC-study, which evaluated adding 18FFDG-PET/CT and SL to staging advanced gastric cancer (cT3–4 and/or cN+) in 18 Dutch hospitals. The Dutch Healthcare Authority provided 18FFDG-PET/CT unit costs. SL unit costs were calculated bottom-up. Gastrectomy-associated costs were collected with hospital claim data until 30 days postoperatively. Uncertainty was assessed in a probabilistic sensitivity analysis (1000 iterations). Results: 18FFDG-PET/CT costs were €1104 including biopsy/cytology. Bottom-up calculations totaled €1537 per SL. D2-gastrectomy costs were €19,308. Total costs per patient were €18,137 for strategy 1, €17,079 for strategy 2, and €19,805 for strategy 3. If all patients undergo gastrectomy, total costs were €18,959 per patient (strategy 4). Performing SL only reduced costs by €1880 per patient. Adding 18FFDG-PET/CT to SL increased costs by €1058 per patient; IQR €870–1253 in the sensitivity analysis. Conclusions:For advanced gastric cancer, performing SL resulted in substantial cost savings by reducing unnecessary gastrectomies. In contrast, routine 18FFDG-PET/CT increased costs without substantially reducing unnecessary gastrectomies, and is not recomme

Published
2024

22. Nationwide Association of Surgical Performance of Minimally Invasive Esophagectomy With Patient Outcomes

Author

Ketel, Mirte H M, Klarenbeek, Bastiaan R, Abma, Inger, Belgers, Eric H J, Coene, Peter-Paul L O, Dekker, Jan Willem T, van Duijvendijk, Peter, Emous, Marloes, Gisbertz, Suzanne S, Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard A P, Ruurda, Jelle P, van Sandick, Johanna W, van der Sluis, Pieter C, van Det, Marc J, van Esser, Stijn, Law, Simon, de Steur, Wobbe O, Sosef, Meindert N, Wijnhoven, Bas, Hannink, Gerjon, Rosman, Camiel, van Workum, Frans, Ketel, Mirte H M, Klarenbeek, Bastiaan R, Abma, Inger, Belgers, Eric H J, Coene, Peter-Paul L O, Dekker, Jan Willem T, van Duijvendijk, Peter, Emous, Marloes, Gisbertz, Suzanne S, Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard A P, Ruurda, Jelle P, van Sandick, Johanna W, van der Sluis, Pieter C, van Det, Marc J, van Esser, Stijn, Law, Simon, de Steur, Wobbe O, Sosef, Meindert N, Wijnhoven, Bas, Hannink, Gerjon, Rosman, Camiel, and van Workum, Frans

Abstract

IMPORTANCE: Suboptimal surgical performance is hypothesized to be associated with less favorable patient outcomes in minimally invasive esophagectomy (MIE). Establishing this association may lead to programs that promote better surgical performance of MIE and improve patient outcomes.OBJECTIVE: To investigate associations between surgical performance and postoperative outcomes after MIE.DESIGN, SETTING, AND PARTICIPANTS: In this nationwide cohort study of 15 Dutch hospitals that perform more than 20 MIEs per year, 7 masked expert MIE surgeons assessed surgical performance using videos and a previously developed and validated competency assessment tool (CAT). Each hospital submitted 2 representative videos of MIEs performed between November 4, 2021, and September 13, 2022. Patients registered in the Dutch Upper Gastrointestinal Cancer Audit between January 1, 2020, and December 31, 2021, were included to examine patient outcomes.EXPOSURE: Hospitals were divided into quartiles based on their MIE-CAT performance score. Outcomes were compared between highest (top 25%) and lowest (bottom 25%) performing quartiles. Transthoracic MIE with gastric tube reconstruction.MAIN OUTCOME AND MEASURE: The primary outcome was severe postoperative complications (Clavien-Dindo ≥3) within 30 days after surgery. Multilevel logistic regression, with clustering of patients within hospitals, was used to analyze associations between performance and outcomes.RESULTS:In total, 30 videos and 970 patients (mean [SD] age, 66.6 [9.1] years; 719 men [74.1%]) were included. The mean (SD) MIE-CAT score was 113.6 (5.5) in the highest performance quartile vs 94.1 (5.9) in the lowest. Severe postoperative complications occurred in 18.7% (41 of 219) of patients in the highest performance quartile vs 39.2% (40 of 102) in the lowest (risk ratio [RR], 0.50; 95% CI, 0.24-0.99). The highes

Published
2024

23. Prognostic value of Mandard score and nodal status for recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma

Author

Henckens, Sofie P.G., Liu, Dajia, Gisbertz, Suzanne S., Kalff, Marianne C., Anderegg, Maarten C.J., Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., van Duijvendijk, Peter, Eshuis, Wietse J., Groenendijk, Richard P.R., Haveman, Jan Willem, van Hillegersberg, Richard, Luyer, Misha D.P., Olthof, Pim B., Pierie, Jean Pierre E.N., Plat, Victor D., Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Sosef, Meindert N., Voeten, Daan M., Vijgen, Guy H.E.J., Bijlsma, Maarten F., Meijer, Sybren L., Hulshof, Maarten C.C.M., Oyarce, Cesar, Lagarde, Sjoerd M., van Laarhoven, Hanneke W.M., van Berge Henegouwen, Mark I., Henckens, Sofie P.G., Liu, Dajia, Gisbertz, Suzanne S., Kalff, Marianne C., Anderegg, Maarten C.J., Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., van Duijvendijk, Peter, Eshuis, Wietse J., Groenendijk, Richard P.R., Haveman, Jan Willem, van Hillegersberg, Richard, Luyer, Misha D.P., Olthof, Pim B., Pierie, Jean Pierre E.N., Plat, Victor D., Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Sosef, Meindert N., Voeten, Daan M., Vijgen, Guy H.E.J., Bijlsma, Maarten F., Meijer, Sybren L., Hulshof, Maarten C.C.M., Oyarce, Cesar, Lagarde, Sjoerd M., van Laarhoven, Hanneke W.M., and van Berge Henegouwen, Mark I.

Abstract

BACKGROUND: This study evaluated the association of pathological tumour response (tumour regression grade, TRG) and a novel scoring system, combining both TRG and nodal status (TRG-ypN score; TRG1-ypN0, TRG>1-ypN0, TRG1-ypN+ and TRG>1-ypN+), with recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma. METHODS: This Dutch nationwide cohort study included patients treated with neoadjuvant chemoradiotherapy followed by oesophagectomy for distal oesophageal or gastro-oesophageal junctional adenocarcinoma between 2007 and 2016. The primary endpoint was the association of Mandard score and TRG-ypN score with recurrence patterns (rate, location, and time to recurrence). The secondary endpoint was overall survival. RESULTS: Among 2746 inclusions, recurrence rates increased with higher Mandard scores (TRG1 30.6%, TRG2 44.9%, TRG3 52.9%, TRG4 61.4%, TRG5 58.2%; P < 0.001). Among patients with recurrent disease, the distribution (locoregional versus distant) was the same for the different TRG groups. Patients with TRG1 developed more brain recurrences (17.7 versus 9.8%; P = 0.001) and had a longer mean overall survival (44 versus 35 months; P < 0.001) than those with TRG>1. The TRG>1-ypN+ group had the highest recurrence rate (64.9%) and worst overall survival (mean 27 months). Compared with the TRG>1-ypN0 group, patients with TRG1-ypN+ had a higher risk of recurrence (51.9 versus 39.6%; P < 0.001) and worse mean overall survival (33 versus 41 months; P < 0.001). CONCLUSION: Improved tumour response to neoadjuvant therapy was associated with lower recurrence rates and higher overall survival rates. Among patients with recurrent disease, TRG1 was associated with a higher incidence of brain recurrence than TRG>1. Residual nodal disease influenced prognosis more negatively than residual disease at the primary tumour site.

Published
2024

24. Worldwide Techniques and Outcomes in Robot-assisted Minimally Invasive Esophagectomy (RAMIE): Results From the Multicenter International Registry

Author

Kingma, B. Feike, Grimminger, Peter P., van der Sluis, Pieter C., van Det, Marc J., Kouwenhoven, Ewout A., Chao, Yin-Kai, Tsai, Chun-Yi, Fuchs, Hans F., Bruns, Christiane J., Sarkaria, Inderpal S., Luketich, James D., Haveman, Jan W., Etten, Boudewijn van, Chiu, Philip W., Chan, Shannon M., Rouanet, Philippe, Mourregot, Anne, Hölzen, Jens-Peter, Sallum, Rubens A., Cecconello, Ivan, Egberts, Jan-Hendrik, Benedix, Frank, van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Perez, Daniel, Jansen, Kristina, Hubka, Michal, Low, Donald E., Biebl, Matthias, Pratschke, Johann, Turner, Paul, Pursnani, Kish, Chaudry, Asif, Smith, Myles, Mazza, Elena, Strignano, Paolo, Ruurda, Jelle P., and van Hillegersberg, Richard

Published
2022
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25. Recurrent Disease After Esophageal Cancer Surgery: A Substudy of The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., Henckens, Sofie P.G., Voeten, Daan M., Heineman, David J., Hulshof, Maarten C.C.M., van Laarhoven, Hanneke W.M., Eshuis, Wietse J., Baas, Peter C., Bahadoer, Renu R., Belt, Eric J.T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P.R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan W., Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E.N., Pierik, E.G.J.M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A.M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B.A.C., Stoop, Fanny J., Vugts, Guusje, Vijgen, Guy H.E.J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G.H., van Berge Henegouwen, Mark I., and Gisbertz, Suzanne S.

Published
2022
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27. Impact of 18FFDG-PET/CT and Laparoscopy in Staging of Locally Advanced Gastric Cancer: A Cost Analysis in the Prospective Multicenter PLASTIC-Study.

Author

de Jongh, Cas, van der Meulen, Miriam P., Gertsen, Emma C., Brenkman, Hylke J. F., van Sandick, Johanna W., van Berge Henegouwen, Mark I., Gisbertz, Suzanne S., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., van Lanschot, Jan J. B., Lagarde, Sjoerd M., Wijnhoven, Bas P. L., de Steur, Wobbe O., Hartgrink, Henk H., Stoot, Jan H. M. B., Hulsewe, Karel W. E., Spillenaar Bilgen, Ernst Jan, van Det, Marc J., Kouwenhoven, Ewout A., and Daams, Freek

Abstract

Background: Unnecessary D2-gastrectomy and associated costs can be prevented after detecting non-curable gastric cancer, but impact of staging on treatment costs is unclear. This study determined the cost impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FFDG-PET/CT) and staging laparoscopy (SL) in gastric cancer staging. Materials and Methods: In this cost analysis, four staging strategies were modeled in a decision tree: (1) 18FFDG-PET/CT first, then SL, (2) SL only, (3) 18FFDG-PET/CT only, and (4) neither SL nor 18FFDG-PET/CT. Costs were assessed on the basis of the prospective PLASTIC-study, which evaluated adding 18FFDG-PET/CT and SL to staging advanced gastric cancer (cT3–4 and/or cN+) in 18 Dutch hospitals. The Dutch Healthcare Authority provided 18FFDG-PET/CT unit costs. SL unit costs were calculated bottom-up. Gastrectomy-associated costs were collected with hospital claim data until 30 days postoperatively. Uncertainty was assessed in a probabilistic sensitivity analysis (1000 iterations). Results: 18FFDG-PET/CT costs were €1104 including biopsy/cytology. Bottom-up calculations totaled €1537 per SL. D2-gastrectomy costs were €19,308. Total costs per patient were €18,137 for strategy 1, €17,079 for strategy 2, and €19,805 for strategy 3. If all patients undergo gastrectomy, total costs were €18,959 per patient (strategy 4). Performing SL only reduced costs by €1880 per patient. Adding 18FFDG-PET/CT to SL increased costs by €1058 per patient; IQR €870–1253 in the sensitivity analysis. Conclusions: For advanced gastric cancer, performing SL resulted in substantial cost savings by reducing unnecessary gastrectomies. In contrast, routine 18FFDG-PET/CT increased costs without substantially reducing unnecessary gastrectomies, and is not recommended due to limited impact with major costs. Trial registration: NCT03208621. This trial was registered prospectively on 30-06-2017. [ABSTRACT FROM AUTHOR]

Published
2024
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28. The Comprehensive Complication Index versus Clavien-Dindo grading after laparoscopic and open D2-gastrectomy in the multicenter randomized LOGICA-trial

Author

Triemstra, Lianne, primary, de Jongh, Cas, additional, Tedone, Fabrizio, additional, Brosens, Lodewijk A.A., additional, Luyer, Misha D.P., additional, Stoot, Jan H.M.B., additional, Lagarde, Sjoerd M., additional, van Hillegersberg, Richard, additional, Ruurda, Jelle P., additional, Brenkman, Hylke J.F., additional, van der Veen, Arjen, additional, Nieuwenhuijzen, Grard A.P., additional, Ponten, Jeroen E.H., additional, Tegels, Juul J.W., additional, Hulsewe, Karel W.E., additional, Wijnhoven, Bas P.L., additional, Lanschot, Jan J.B., additional, de Steur, Wobbe O., additional, Hartgrink, Henk H., additional, Kouwenhoven, Ewout A., additional, van Det, Marc J., additional, Wassenaar, Eelco B., additional, van Duijvendijk, P., additional, Draaisma, Werner A., additional, Broeders, Ivo A.M.J., additional, van der Peet, Donald L., additional, and Gisbertz, Suzanne S., additional

Published
2023
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29. Trends in Distal Esophageal and Gastroesophageal Junction Cancer Care: The Dutch Nationwide Ivory Study

Author

Kalff, Marianne C., Henegouwen, Mark I. van Berge, Baas, Peter C., Bahadoer, Renu R., Belt, Eric J. T., Brattinga, Baukje, Claassen, Linda, Ćosović, Admira, Crull, David, Daams, Freek, van Dalsen, Annette D., Dekker, Jan Willem T., van Det, Marc J., Drost, Manon, van Duijvendijk, Peter, Eshuis, Wietse J., van Esser, Stijn, Gaspersz, Marcia P., Görgec, Burak, Groenendijk, Richard P. R., Hartgrink, Henk H., van der Harst, Erwin, Haveman, Jan Willem, Heisterkamp, Joos, van Hillegersberg, Richard, Kelder, Wendy, Kingma, B. Feike, Koemans, Willem J., Kouwenhoven, Ewout A., Lagarde, Sjoerd M., Lecot, Frederik, van der Linden, Philip P., Luyer, Misha D. P., Nieuwenhuijzen, Grard A. P., Olthof, Pim B., van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, E. G. J. M. Robert, Plat, Victor D., Polat, Fatih, Rosman, Camiel, Ruurda, Jelle P., van Sandick, Johanna W., Scheer, Rene, Slootmans, Cettela A. M., Sosef, Meindert N., Sosef, Odin V., de Steur, Wobbe O., Stockmann, Hein B. A. C., Stoop, Fanny J., Voeten, Daan M., Vugts, Guusje, Vijgen, Guy H. E. J., Weeda, Víola B., Wiezer, Marinus J., van Oijen, Martijn G. H., and Gisbertz, Suzanne S.

Published
2021
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30. Learning Curves of Ivor Lewis Totally Minimally Invasive Esophagectomy by Hospital and Surgeon Characteristics: A Retrospective Multinational Cohort Study

Author

Claassen, Linda, Hannink, Gerjon, Luyer, Misha D. P., Ainsworth, Alan P., Henegouwen, Mark I. van Berge, Cheong, Edward, Daams, Freek, van Det, Marc J., van Duijvendijk, Peter, Gisbertz, Suzanne S., Gutschow, Christian A., Heisterkamp, Joos, Kauppi, Juha T., Klarenbeek, Bastiaan R., Kouwenhoven, Ewout A., Langenhoff, Barbara S., Larsen, Michael H., Martijnse, Ingrid S., Nieuwenhoven, Ernst Jan van, van der Peet, Donald L., Pierie, Jean-Pierre E. N., Pierik, Robert E. G. J. M., Polat, Fatih, Rusanen, Jari V., Rouvelas, Ioannis, Sosef, Meindert N., Wassenaar, Eelco B., Wildenberg, Frits J. H. van den, van der Zaag, Edwin S., Nilsson, Magnus, Nieuwenhuijzen, Grard A. P., van Workum, Frans, and Rosman, Camiel

Published
2022
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33. Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial

Author

Andeweg, Caroline S., Bastiaenen, Vivian P., Bemelman, Willem A., van der Bilt, Jarmila D.W., Bloemen, Johanne, den Boer, Frank C., Boerma, Djamila, ten Bokkel Huinink, Daan, Brokelman, Walter J.A., Cense, Huib A., Consten, Esther C.J., Creemers, Geert-Jan, Crolla, Rogier M.P.H., Dekker, Jan-Willem T., Demelinne, Jennifer, van Det, Marc J., van Diepen, Karin K., Diepeveen, Marjolein, van Duyn, Eino B., van den Ende, Esther D., Evers, Pauline, van Geloven, Anna A.W., van der Harst, Erwin, Heemskerk, Jeroen, Heikens, Joost T., Hess, Daniel A., Inberg, Bas, Jansen, Jan, Kloppenberg, Frank W.H., Kootstra, Thomas J.M., Kortekaas, R.T.J., Los, Maartje, Madsen, Eva V.E., van der Mijle, H.C.J., Mol, Linda, Neijenhuis, Peter A., Nienhuijs, Simon W., van den Nieuwenhof, Loes, Peeters, Koen C.M.J., Polle, Sebastiaan W., Pon, Jolien, Poortman, Pieter, Radema, Sandra A., van Ramshorst, Bert, de Reuver, Philip R., Rovers, Koen P., Schmitz, Roderick F., Sluiter, Nina, Sommeijer, Dirkje W., Sonneveld, D.J.A., van Sprundel, T.C., Veltkamp, Sanne C., Vermaas, Maarten, Verwaal, Victor J., Wassenaar, Emma, Wegdam, Johannes A., de Wilt, Johannes H.W., Westerterp, Marinke, Wit, Fennie, Witkamp, Arjen J., van Woensdregt, Karlijn, van der Zaag, Edwin S., Zournas, Mandy, Klaver, Charlotte E L, Wisselink, Daniel D, Punt, Cornelis J A, Snaebjornsson, Petur, Crezee, Johannes, Aalbers, Arend G J, Brandt, Alexandra, Bremers, Andre J A, Burger, Jacobus W A, Fabry, Hans F J, Ferenschild, Floris, Festen, Sebastiaan, van Grevenstein, Wilhelmina M U, Hemmer, Patrick H J, de Hingh, Ignace H J T, Kok, Niels F M, Musters, Gijsbert D, Schoonderwoerd, Lotte, Tuynman, Jurriaan B, van de Ven, Anthony W H, van Westreenen, Henderik L, Wiezer, Marinus J, Zimmerman, David D E, van Zweeden, Annette A, Dijkgraaf, Marcel G W, and Tanis, Pieter J

Published
2019
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34. A New Procedure-Based Assessment of Operative Skills in Gastric Bypass Surgery, Evaluated by Video Fragment Rating.

Author

Kaijser, Mirjam A., van Ramshorst, Gabrielle H., van Wagensveld, Bart A., Veeger, Nic J. G. M., Pierie, Jean-Pierre E. N., Damen, Stefan L., van Det, Marc J., Emous, Marloes, van den Ende, Esther D., Jutte, Ewoud H., Hazebroek, Eric J., Hof, Gerhard van't, Klaassen, René A., Langenhoff, Barbara S., Liem, Ronald S. L., Marsman, Hendrik A., Nienhuijs, Simon W., and van Nieuwenhove, Yves

Subjects
GASTRIC bypass, VIDEO recording, VIDEOS, BARIATRIC surgery
Abstract

Purpose: Feedback on technical and procedural skills is essential during the training of residents and fellows. The aim of this study was to assess the performance of a newly created instrument for the assessment of operative skills using laparoscopic Roux-en-Y gastric bypass (LRYGB) video fragments. Materials and Methods: A new procedure-based assessment (PBA) was created by combining LRYGB key steps with a 5-point independence scale. LRYGB performed by residents and surgeons with different levels of expertise were video recorded. Fragments of the pouch creation, gastro-jejunostomy and jejunojejunostomy, were review by 12 expert bariatric surgeons and the operative skills assessed with the PBA, Objective Structured Assessment of Technical Skill (OSATS), and the Bariatric OSATS (BOSATS). The PBA was compared to the OSATS and BOSATS. Mean scores for all items of the different assessments were summarized and compared using a T-test. Results: The scores of the procedural steps were combined and compared for all levels. The mean scores for beginner, intermediate, and expert level were 2.71, 3.70, and 3.90 for the PBA; for the OSATS 1.84, 2.86, and 3.44; and for the BOSATS 2.78, 3.56, and 4.19. Each of these assessments differentiated between the three skill levels (all p < 0.05). Conclusion: The PBA discriminates well between different levels of operative skills. Similar patterns were found for the OSATS and BOSATS, showing that the randomly selected video fragments are representative samples for assessing skill level. Future research will demonstrate whether these results can be extrapolated to clinical training, and which scores allow for procedure certification. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Long-Term Survival Associated with Direct Oral Feeding Following Minimally Invasive Esophagectomy: Results from a Randomized Controlled Trial (NUTRIENT II)

Author

Geraedts, Tessa C. M., primary, Weijs, Teus J., additional, Berkelmans, Gijs H. K., additional, Fransen, Laura F. C., additional, Kouwenhoven, Ewout A., additional, van Det, Marc J., additional, Nilsson, Magnus, additional, Lagarde, Sjoerd M., additional, van Hillegersberg, Richard, additional, Markar, Sheraz R., additional, Nieuwenhuijzen, Grard A. P., additional, and Luyer, Misha D. P., additional

Published
2023
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36. Surgical quality and prospective quality control of the D2-gastrectomy for gastric cancer in the multicenter randomized LOGICA-trial

Author

de Jongh, Cas, primary, Triemstra, Lianne, additional, van der Veen, Arjen, additional, Brosens, Lodewijk AA., additional, Nieuwenhuijzen, Grard AP., additional, Stoot, Jan HMB., additional, de Steur, Wobbe O., additional, Ruurda, Jelle P., additional, van Hillegersberg, Richard, additional, Brenkman, Hylke JF., additional, Seesing, Maarten F.J., additional, Luyer, Misha DP., additional, Ponten, Jeroen EH., additional, Tegels, Juul JW., additional, Hulsewe, Karel WE., additional, Hartgrink, Henk H., additional, Wijnhoven, Bas PL., additional, Lagarde, Sjoerd M., additional, Kouwenhoven, Ewout A., additional, van Det, Marc J., additional, Wassenaar, Eelco B., additional, van Duijvendijk, P., additional, Draaisma, Werner A., additional, Broeders, Ivo AMJ., additional, van der Peet, Donald L., additional, and Gisbertz, Suzanne S., additional

Published
2023
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37. Erratum to “Practice variation in anastomotic leak after esophagectomy: Unravelling differences in failure to rescue” [Eur J Surg Oncol 49 (5) (May 2023) 974–982]

Author

Ubels, Sander, primary, Matthée, Eric, additional, Verstegen, Moniek, additional, Klarenbeek, Bastiaan, additional, Bouwense, Stefan, additional, van Berge Henegouwen, Mark I., additional, Daams, Freek, additional, Dekker, Jan Willem T., additional, van Det, Marc J., additional, van Esser, Stijn, additional, Griffiths, Ewen A., additional, Haveman, Jan Willem, additional, Nieuwenhuijzen, Grard, additional, Siersema, Peter D., additional, Wijnhoven, Bas, additional, Hannink, Gerjon, additional, van Workum, Frans, additional, Rosman, Camiel, additional, Heisterkamp, Joos, additional, Polat, Fatih, additional, Schouten, Jeroen, additional, Singh, Pritam, additional, Slootmans, Cettela A.M., additional, Ultee, Gijs, additional, Gisbertz, Suzanne S., additional, Eshuis, Wietse J., additional, Kalff, Marianne C., additional, Feenstra, Minke L., additional, van der Peet, Donald L., additional, Stam, Wessel T., additional, Van Etten, Boudewijn, additional, Poelmann, Floris, additional, Vuurberg, Nienke, additional, Willem van den Berg, Jan, additional, Martijnse, Ingrid S., additional, Matthijsen, Robert M., additional, Luyer, Misha, additional, Curvers, Wout, additional, Nieuwenhuijzen, Tom, additional, Taselaar, Annick E., additional, Kouwenhoven, Ewout A., additional, Lubbers, Merel, additional, Sosef, Meindert, additional, Lecot, Frederik, additional, Geraedts, Tessa C.M., additional, van den Wildenberg, Frits, additional, Kelder, Wendy, additional, Baas, Peter C., additional, de Haas, Job W.A., additional, Hartgrink, Henk H., additional, Bahadoer, Renu R., additional, van Sandick, Johanna W., additional, Hartemink, Koen J., additional, Veenhof, Xander, additional, Stockmann, Hein, additional, Gorgec, Burak, additional, Weeder, Pepijn, additional, Wiezer, Marinus J., additional, Genders, Charlotte M.S., additional, Belt, Eric, additional, Blomberg, Bjorn, additional, van Duijvendijk, Peter, additional, Claassen, Linda, additional, Reetz, David, additional, Steenvoorde, Pascal, additional, Mastboom, Walter, additional, Klein Ganseij, Henk Jan, additional, van Dalsen, Annette D., additional, Joldersma, Annalie, additional, Zwakman, Marije, additional, Groenendijk, Richard P.R., additional, Montazeri, Mahsa, additional, Mercer, Stuart, additional, Knight, Benjamin, additional, van Boxel, Gijs, additional, McGregor, Richard J., additional, Skipworth, Richard J.E., additional, Frattini, Cristina, additional, Bradley, Alice, additional, Nilsson, Magnus, additional, Hayami, Masaru, additional, Huang, Biying, additional, Bundred, James, additional, Evans, Richard, additional, Grimminger, Peter P., additional, van der Sluis, Pieter C., additional, Eren, Uzun, additional, Saunders, John, additional, Theophilidou, Elena, additional, Khanzada, Zubair, additional, Elliott, Jessie A., additional, Ponten, Jeroen, additional, King, Sinead, additional, Reynolds, John V., additional, Sgromo, Bruno, additional, Akbari, Khalid, additional, Shalaby, Samar, additional, Gutschow, Christian A., additional, Schmidt, Henner, additional, Vetter, Diana, additional, Moorthy, Krishna, additional, Ibrahim, Mohamed A.H., additional, Christodoulidis, Grigorious, additional, Räsänen, Jari V., additional, Kauppi, Juha, additional, Söderström, Henna, additional, Koshy, Renol, additional, Manatakis, Dimitrios K., additional, Korkolis, Dimitrios P., additional, Balalis, Dimitrios, additional, Rompu, Aliki, additional, Alkhaffaf, Bilal, additional, Alasmar, Mohamed, additional, Arebi, Moaad, additional, Piessen, Guillaume, additional, Nuytens, Frederiek, additional, Degisors, Sebastien, additional, Ahmed, Ahmed, additional, Boddy, Alex, additional, Gandhi, Suraj, additional, Fashina, Oluwatomini, additional, Van Daele, Elke, additional, Pattyn, Piet, additional, Robb, William B., additional, Arumugasamy, Mayilone, additional, Al Azzawi, Mohammed, additional, Whooley, Jack, additional, Colak, Elif, additional, Aybar, Engin, additional, Sari, Ahmet C., additional, Uyanik, Mustafa S., additional, Ciftci, Ahmet B., additional, Sayyed, Raza, additional, Ayub, Bushra, additional, Murtaza, Ghulam, additional, Saeed, Aniqa, additional, Ramesh, Priyanka, additional, Charalabopoulos, Alexandros, additional, Liakakos, Theodore, additional, Schizas, Dimitrios, additional, Baili, Efstratia, additional, Kapelouzou, Alkistis, additional, Valmasoni, Michele, additional, Pierobon, Elisa Sefora, additional, Capovilla, Giovanni, additional, Merigliano, Stefano, additional, Constantinoiu, Silviu, additional, Birla, Rodica, additional, Achim, Florin, additional, Rosianu, Cristian Gelu, additional, Hoara, Petre, additional, Castro, Raúl Guevara, additional, Salcedo, Andrés Felipe, additional, Negoi, Ionut, additional, Negoita, Valentina M., additional, Ciubotaru, Cezar, additional, Stoica, Bogdan, additional, Hostiuc, Sorin, additional, Colucci, Nicola, additional, Mönig, Stefan P., additional, Wassmer, Charles-Henri, additional, Meyer, Jeremy, additional, Takeda, Flavio Roberto, additional, Aissar Sallum, Rubens Antonio, additional, Ribeiro, Ulysses, additional, Cecconello, Ivan, additional, Toledo, Enrique, additional, Trugeda, Maria Soledad, additional, Fernández, María José, additional, Gil, Carolina, additional, Castanedo, Sonia, additional, Isik, Arda, additional, Kurnaz, Eray, additional, Videira, José Flávio, additional, Peyroteo, Mariana, additional, Canotilho, Rita, additional, Weindelmayer, Jacopo, additional, Giacopuzzi, Simone, additional, De Pasqual, Carlo Alberto, additional, Bruna, Marcos, additional, Mingol, Fernando, additional, Vaque, Javier, additional, Pérez, Carla, additional, Phillips, Alexander W., additional, Chmelo, Jakub, additional, Brown, Joshua, additional, Han, Laura E., additional, Gossage, James A., additional, Davies, Andrew R., additional, Baker, Cara R., additional, Kelly, Mark, additional, Saad, Mohamed, additional, Bernardi, Daniele, additional, Bonavina, Luigi, additional, Asti, Emanuele, additional, Riva, Carlo, additional, Scaramuzzo, Rosa, additional, Elhadi, Muhammed, additional, Ahmed, Hazem Abdelkarem, additional, Elhadi, Ahmed, additional, Elnagar, Faruk Ali, additional, Msherghi, Ahmed A.A., additional, Wills, Vanessa, additional, Campbell, Cassidy, additional, Cerdeira, Marisol Perez, additional, Whiting, Scott, additional, Merrett, Neil, additional, Das, Amitabha, additional, Apostolou, Christos, additional, Lorenzo, Aldenb, additional, Sousa, Fabiana, additional, Barbosa, José Adelino, additional, Devezas, Vítor, additional, Barbosa, Elisabete, additional, Fernandes, Cristina, additional, Smith, Garett, additional, Li, Edward Y., additional, Bhimani, Nazim, additional, Chan, Priscilla, additional, Kotecha, Krishna, additional, Hii, Michael W., additional, Ward, Salena M., additional, Johnson, MaryAnn, additional, Read, Matthew, additional, Chong, Lynn, additional, Hollands, Michael J., additional, Allaway, Matthew, additional, Richardson, Arthur, additional, Johnston, Emma, additional, Chen, Andy Z.L., additional, Kanhere, Harsh, additional, Prasad, Shalvin, additional, McQuillan, Patrick, additional, Surman, Tim, additional, Trochsler, MarkusI., additional, Schofield, W.A., additional, Ahmed, Syeda Khadijah, additional, Reid, Jessica L., additional, Harris, Mark C., additional, Gananadha, Sivakumar, additional, Farrant, Jessica, additional, Rodrigues, Nicole, additional, Fergusson, James, additional, Hindmarsh, Andrew, additional, Afzal, Zeeshan, additional, Safranek, Peter, additional, Sujendran, Vijay, additional, Rooney, Siobhan, additional, Loureiro, Carlos, additional, Fernández, Saioa Leturio, additional, Díez del Val, Ismael, additional, Jaunoo, Shameen, additional, Kennedy, Lauren, additional, Hussain, Ahmed, additional, Theodorou, Dimitrios, additional, Triantafyllou, Tania, additional, Theodoropoulos, Charalampos, additional, Palyvou, Theodora, additional, Ben Taher, Fatima Abdullah, additional, and Ekheel, Mustafa, additional

Published
2023
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38. Effects of Community-based Exercise Prehabilitation for Patients Scheduled for Colorectal Surgery With High Risk for Postoperative Complications: Results of a Randomized Clinical Trial

Author

Berkel, Annefleur E. M., Bongers, Bart C., Kotte, Hayke, Weltevreden, Paul, de Jongh, Frans H. C., Eijsvogel, Michiel M. M., Wymenga, A. N. Machteld, Bigirwamungu-Bargeman, Marloes, van der Palen, Job, van Det, Marc J., van Meeteren, Nico L. U., and Klaase, Joost M.

Published
2021
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39. Worldwide Techniques and Outcomes in Robot-Assisted Minimally Invasive Esophagectomy (RAMIE): Results from the Multicenter International Registry

Author

Kingma, B. Feike, Grimminger, Peter P., van der Sluis, Pieter C., van Det, Marc J., Kouwenhoven, Ewout A., Chao, Yin-Kai, Tsai, Chun-Yi, Fuchs, Hans F., Bruns, Christiane J., Sarkaria, Inderpal S., Luketich, James D., Haveman, Jan W., van Etten, Boudewijn, Chiu, Philip W., Chan, Shannon M., Rouanet, Philippe, Mourregot, Anne, Hölzen, Jens-Peter, Sallum, Rubens A., Cecconello, Ivan, Egberts, Jan-Hendrik, Benedix, Frank, Henegouwen, Mark I. van Berge, Gisbertz, Suzanne S., Perez, Daniel, Jansen, Kristina, Hubka, Michal, Low, Donald E., Biebl, Matthias, Pratschke, Johann, Turner, Paul, Pursnani, Kish, Chaudry, Asif, Smith, Myles, Mazza, Elena, Strignano, Paolo, Ruurda, Jelle P., and van Hillegersberg, Richard

Published
2020
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42. Prognostic value of Mandard score and nodal status for recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma.

Author

Henckens, Sofie P G, Liu, Dajia, Gisbertz, Suzanne S, Kalff, Marianne C, Anderegg, Maarten C J, Crull, David, Daams, Freek, van Dalsen, Annette D, Dekker, Jan Willem T, van Det, Marc J, van Duijvendijk, Peter, Eshuis, Wietse J, Groenendijk, Richard P R, Haveman, Jan Willem, van Hillegersberg, Richard, Luyer, Misha D P, Olthof, Pim B, Pierie, Jean-Pierre E N, Plat, Victor D, and Rosman, Camiel

Subjects
PROGNOSIS, COMBINED modality therapy, OVERALL survival, NEOADJUVANT chemotherapy, ADENOCARCINOMA, RECTAL cancer, HEARTBURN
Abstract

Background: This study evaluated the association of pathological tumour response (tumour regression grade, TRG) and a novel scoring system, combining both TRG and nodal status (TRG-ypN score; TRG1-ypN0, TRG>1-ypN0, TRG1-ypN+ and TRG>1-ypN+), with recurrence patterns and survival after multimodal treatment of oesophageal adenocarcinoma. Methods: This Dutch nationwide cohort study included patients treated with neoadjuvant chemoradiotherapy followed by oesophagectomy for distal oesophageal or gastro-oesophageal junctional adenocarcinoma between 2007 and 2016. The primary endpoint was the association of Mandard score and TRG-ypN score with recurrence patterns (rate, location, and time to recurrence). The secondary endpoint was overall survival. Results: Among 2746 inclusions, recurrence rates increased with higher Mandard scores (TRG1 30.6%, TRG2 44.9%, TRG3 52.9%, TRG4 61.4%, TRG5 58.2%; P < 0.001). Among patients with recurrent disease, the distribution (locoregional versus distant) was the same for the different TRG groups. Patients with TRG1 developed more brain recurrences (17.7 versus 9.8%; P = 0.001) and had a longer mean overall survival (44 versus 35 months; P < 0.001) than those with TRG>1. The TRG>1-ypN+ group had the highest recurrence rate (64.9%) and worst overall survival (mean 27 months). Compared with the TRG>1-ypN0 group, patients with TRG1-ypN+ had a higher risk of recurrence (51.9 versus 39.6%; P < 0.001) and worse mean overall survival (33 versus 41 months; P < 0.001). Conclusion: Improved tumour response to neoadjuvant therapy was associated with lower recurrence rates and higher overall survival rates. Among patients with recurrent disease, TRG1 was associated with a higher incidence of brain recurrence than TRG>1. Residual nodal disease influenced prognosis more negatively than residual disease at the primary tumour site. In this Dutch nationwide cohort study, improved tumour response to neoadjuvant therapy was associated with a lower recurrence rate and higher overall survival rate. Among patients with recurrent disease, tumour regression grade (TRG) 1 was associated with a higher incidence of brain recurrences than TRG greater than 1. Residual nodal disease influenced prognosis more negatively than residual disease at the primary tumour site. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Development of a Core Set of Self-Management Support Needs of Esophageal Cancer Patients: Results from a Delphi Study among Healthcare Professionals

Author

Adriaans, Daniëlle J. M., primary, Heesakkers, Fanny B. M., additional, Teijink, Joep A. W., additional, Dierick-van Daele, Angelique T. M., additional, Haveman, Jan Willem, additional, Sosef, Meindert N., additional, van den Berg, Jan Willem, additional, van Det, Marc J., additional, Hartgrink, Henk H., additional, Jansen, Walther J. B. M., additional, Rosman, Camiel, additional, Lagarde, Sjoerd M., additional, van Esser, Stijn, additional, van der Harst, Erwin, additional, van Laarhoven, Hanneke W. M., additional, and Nieuwenhuijzen, Grard A. P., additional

Published
2023
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46. Long-Term Survival Associated with Direct Oral Feeding Following Minimally Invasive Esophagectomy:Results from a Randomized Controlled Trial (NUTRIENT II)

Author

Geraedts, Tessa C.M., Weijs, Teus J., Berkelmans, Gijs H.K., Fransen, Laura F.C., Kouwenhoven, Ewout A., van Det, Marc J., Nilsson, Magnus, Lagarde, Sjoerd M., van Hillegersberg, Richard, Markar, Sheraz R., Nieuwenhuijzen, Grard A.P., Luyer, Misha D.P., Geraedts, Tessa C.M., Weijs, Teus J., Berkelmans, Gijs H.K., Fransen, Laura F.C., Kouwenhoven, Ewout A., van Det, Marc J., Nilsson, Magnus, Lagarde, Sjoerd M., van Hillegersberg, Richard, Markar, Sheraz R., Nieuwenhuijzen, Grard A.P., and Luyer, Misha D.P.

Abstract

Advancements in perioperative care have improved postoperative morbidity and recovery after esophagectomy. The direct start of oral intake can also enhance short-term outcomes following minimally invasive Ivor Lewis esophagectomy (MIE-IL). Subsequently, short-term outcomes may affect long-term survival. This planned sub-study of the NUTRIENT II trial, a multicenter randomized controlled trial, investigated the long-term survival of direct versus delayed oral feeding following MIE-IL. The outcomes included 3- and 5-year overall survival (OS) and disease-free survival (DFS), and the influence of complications and caloric intake on OS. After excluding cases of 90-day mortality, 145 participants were analyzed. Of these, 63 patients (43.4%) received direct oral feeding. At 3 years, OS was significantly better in the direct oral feeding group (p = 0.027), but not at 5 years (p = 0.115). Moreover, 5-year DFS was significantly better in the direct oral feeding group (p = 0.047) and a trend towards improved DFS was shown at 3 years (p = 0.079). Postoperative complications and caloric intake on day 5 did not impact OS. The results of this study show a tendency of improved 3-year OS and 5-year DFS, suggesting a potential long-term survival benefit in patients receiving direct oral feeding after esophagectomy. However, the findings should be further explored in larger future trials.

Published
2023

47. Pain and Opioid Consumption After Laparoscopic Versus Open Gastrectomy for Gastric Cancer:A Secondary Analysis of a Multicenter Randomized Clinical Trial (LOGICA-Trial)

Author

van der Veen, Arjen, Ramaekers, Mark, Marsman, Marije, Brenkman, Hylke J.F., Seesing, Maarten F.J., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Stoot, Jan H.M.B., Tegels, Juul J.W., Wijnhoven, Bas P.L., de Steur, Wobbe O., Kouwenhoven, Ewout A., Wassenaar, Eelco B., Draaisma, Werner A., Gisbertz, Suzanne S., van der Peet, Donald L., May, Anne M., Ruurda, Jelle P., van Hillegersberg, Richard, Haverkamp, Leonie, Ponten, Jeroen E.H., Heesakkers, Fanny F.B.M., Hulsewe, Karel W.E., Tweed, Thais T.T., Lagarde, Sjoerd M., van Lanschot, Jan J.B., Hartgrink, Henk H., van Det, Marc J., van Duijvendijk, Peter, van der Zaag, Edwin S., Broeders, Ivo A.M.J., van Berge Henegouwen, Mark I., Daams, Freek, van der Veen, Arjen, Ramaekers, Mark, Marsman, Marije, Brenkman, Hylke J.F., Seesing, Maarten F.J., Luyer, Misha D.P., Nieuwenhuijzen, Grard A.P., Stoot, Jan H.M.B., Tegels, Juul J.W., Wijnhoven, Bas P.L., de Steur, Wobbe O., Kouwenhoven, Ewout A., Wassenaar, Eelco B., Draaisma, Werner A., Gisbertz, Suzanne S., van der Peet, Donald L., May, Anne M., Ruurda, Jelle P., van Hillegersberg, Richard, Haverkamp, Leonie, Ponten, Jeroen E.H., Heesakkers, Fanny F.B.M., Hulsewe, Karel W.E., Tweed, Thais T.T., Lagarde, Sjoerd M., van Lanschot, Jan J.B., Hartgrink, Henk H., van Det, Marc J., van Duijvendijk, Peter, van der Zaag, Edwin S., Broeders, Ivo A.M.J., van Berge Henegouwen, Mark I., and Daams, Freek

Abstract

Background:Laparoscopic gastrectomy could reduce pain and opioid consumption, compared to open gastrectomy. However, it is difficult to judge the clinical relevance of this reduction, since these outcomes are reported in few randomized trials and in limited detail. Methods: This secondary analysis of a multicenter randomized trial compared laparoscopic versus open gastrectomy for resectable gastric adenocarcinoma (cT1-4aN0-3bM0). Postoperative pain was analyzed by opioid consumption in oral morphine equivalents (OME, mg/day) at postoperative day (POD) 1–5, WHO analgesic steps, and Numeric Rating Scales (NRS, 0–10) at POD 1–10 and discharge. Regression and mixed model analyses were performed, with and without correction for epidural analgesia. Results: Between 2015 and 2018, 115 patients in the laparoscopic group and 110 in the open group underwent surgery. Some 16 patients (14%) in the laparoscopic group and 73 patients (66%) in the open group received epidural analgesia. At POD 1–3, mean opioid consumption was 131, 118, and 53 mg OME lower in the laparoscopic group, compared to the open group, respectively (all p < 0.001). After correcting for epidural analgesia, these differences remained significant at POD 1–2 (47 mg OME, p = 0.002 and 69 mg OME, p < 0.001, respectively). At discharge, 27% of patients in the laparoscopic group and 43% patients in the open group used oral opioids (p = 0.006). Mean highest daily pain scores were between 2 and 4 at all PODs, < 2 at discharge, and did not relevantly differ between treatment arms. Conclusion: In this multicenter randomized trial, postoperative pain was comparable between laparoscopic and open gastrectomy. After laparoscopic gastrectomy, this was generally achieved without epidural analgesia and with fewer opioids. Trial Registration: NCT02248519.

Published
2023

48. Treatment of anastomotic leak after oesophagectomy for oesophageal cancer:large, collaborative, observational TENTACLE cohort study

Author

Ubels, Sander, Verstegen, Moniek H.P., Klarenbeek, Bastiaan R., Bouwense, Stefan, Van Berge Henegouwen, Mark I., Daams, Freek, Van Det, Marc J., Griffiths, Ewen A., Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard, Polat, Fatih, Schouten, Jeroen, Siersema, Peter D., Singh, Pritam, Wijnhoven, Bas, Hannink, Gerjon, Van Workum, Frans, Rosman, Camiel, Ubels, Sander, Verstegen, Moniek H.P., Klarenbeek, Bastiaan R., Bouwense, Stefan, Van Berge Henegouwen, Mark I., Daams, Freek, Van Det, Marc J., Griffiths, Ewen A., Haveman, Jan Willem, Heisterkamp, Joos, Nieuwenhuijzen, Grard, Polat, Fatih, Schouten, Jeroen, Siersema, Peter D., Singh, Pritam, Wijnhoven, Bas, Hannink, Gerjon, Van Workum, Frans, and Rosman, Camiel

Abstract

Background: Anastomotic leak is a severe complication after oesophagectomy. Anastomotic leak has diverse clinical manifestations and the optimal treatment strategy is unknown. The aim of this study was to assess the efficacy of treatment strategies for different manifestations of anastomotic leak after oesophagectomy. Methods: A retrospective cohort study was performed in 71 centres worldwide and included patients with anastomotic leak after oesophagectomy (2011-2019). Different primary treatment strategies were compared for three different anastomotic leak manifestations: interventional versus supportive-only treatment for local manifestations (that is no intrathoracic collections; well perfused conduit); drainage and defect closure versus drainage only for intrathoracic manifestations; and oesophageal diversion versus continuity-preserving treatment for conduit ischaemia/necrosis. The primary outcome was 90-day mortality. Propensity score matching was performed to adjust for confounders. Results: Of 1508 patients with anastomotic leak, 28.2 per cent (425 patients) had local manifestations, 36.3 per cent (548 patients) had intrathoracic manifestations, 9.6 per cent (145 patients) had conduit ischaemia/necrosis, 17.5 per cent (264 patients) were allocated after multiple imputation, and 8.4 per cent (126 patients) were excluded. After propensity score matching, no statistically significant differences in 90-day mortality were found regarding interventional versus supportive-only treatment for local manifestations (risk difference 3.2 per cent, 95 per cent c.i. -1.8 to 8.2 per cent), drainage and defect closure versus drainage only for intrathoracic manifestations (risk difference 5.8 per cent, 95 per cent c.i. -1.2 to 12.8 per cent), and oesophageal diversion versus continuity-preserving treatment for conduit ischaemia/necrosis (risk difference 0.1 per cent, 95 per cent c.i. -21.4 to 1.6 per cent). In general, less morbidity was found after less extensive primary

Published
2023

49. Practice variation in anastomotic leak after esophagectomy:Unravelling differences in failure to rescue

Author

Ubels, Sander, Matthée, Eric, Verstegen, Moniek, Klarenbeek, Bastiaan, Bouwense, Stefan, van Berge Henegouwen, Mark I., Daams, Freek, Dekker, Jan Willem T., van Det, Marc J., van Esser, Stijn, Griffiths, Ewen A., Haveman, Jan Willem, Nieuwenhuijzen, Grard, Siersema, Peter D., Wijnhoven, Bas, Hannink, Gerjon, van Workum, Frans, Rosman, Camiel, Poelmann, Floris, Ubels, Sander, Matthée, Eric, Verstegen, Moniek, Klarenbeek, Bastiaan, Bouwense, Stefan, van Berge Henegouwen, Mark I., Daams, Freek, Dekker, Jan Willem T., van Det, Marc J., van Esser, Stijn, Griffiths, Ewen A., Haveman, Jan Willem, Nieuwenhuijzen, Grard, Siersema, Peter D., Wijnhoven, Bas, Hannink, Gerjon, van Workum, Frans, Rosman, Camiel, and Poelmann, Floris

Abstract

Introduction: Failure to rescue (FTR) is an important outcome measure after esophagectomy and reflects mortality after postoperative complications. Differences in FTR have been associated with hospital resection volume. However, insight into how centers manage complications and achieve their outcomes is lacking. Anastomotic leak (AL) is a main contributor to FTR. This study aimed to assess differences in FTR after AL between centers, and to identify factors that explain these differences. Methods: TENTACLE – Esophagus is a multicenter, retrospective cohort study, which included 1509 patients with AL after esophagectomy. Differences in FTR were assessed between low-volume (<20 resections), middle-volume (20–60 resections) and high-volume centers (≥60 resections). Mediation analysis was performed using logistic regression, including possible mediators for FTR: case-mix, hospital resources, leak severity and treatment. Results: FTR after AL was 11.7%. After adjustment for confounders, FTR was lower in high-volume vs. low-volume (OR 0.44, 95%CI 0.2–0.8), but not versus middle-volume centers (OR 0.67, 95%CI 0.5–1.0). After mediation analysis, differences in FTR were found to be explained by lower leak severity, lower secondary ICU readmission rate and higher availability of therapeutic modalities in high-volume centers. No statistically significant direct effect of hospital volume was found: high-volume vs. low-volume 0.86 (95%CI 0.4–1.7), high-volume vs. middle-volume OR 0.86 (95%CI 0.5–1.4). Conclusion: Lower FTR in high-volume compared with low-volume centers was explained by lower leak severity, less secondary ICU readmissions and higher availability of therapeutic modalities. To reduce FTR after AL, future studies should investigate effective strategies to reduce leak severity and prevent secondary ICU readmission.

Published
2023

50. Long-Term Survival Associated with Direct Oral Feeding Following Minimally Invasive Esophagectomy: Results from a Randomized Controlled Trial (NUTRIENT II)

Author

MS CGO, Cancer, Geraedts, Tessa C M, Weijs, Teus J, Berkelmans, Gijs H K, Fransen, Laura F C, Kouwenhoven, Ewout A, van Det, Marc J, Nilsson, Magnus, Lagarde, Sjoerd M, van Hillegersberg, Richard, Markar, Sheraz R, Nieuwenhuijzen, Grard A P, Luyer, Misha D P, MS CGO, Cancer, Geraedts, Tessa C M, Weijs, Teus J, Berkelmans, Gijs H K, Fransen, Laura F C, Kouwenhoven, Ewout A, van Det, Marc J, Nilsson, Magnus, Lagarde, Sjoerd M, van Hillegersberg, Richard, Markar, Sheraz R, Nieuwenhuijzen, Grard A P, and Luyer, Misha D P

Published
2023

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