356 results on '"van Dam C"'
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2. Moeheid (chronisch vermoeidheidssyndroom)
- Author
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van Dam, C. S., de Vries, H., de Jongh, T.O.H., editor, and de Vries, H., editor
- Published
- 2018
- Full Text
- View/download PDF
3. Wind Energy Forecasting: A Review of State-of-the-Art and Recommendations for Better Forecasts
- Author
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Huang, Junhui, Shiu, Henry, and van Dam, C P.
- Abstract
Wind energy in the United States has increased dramatically over the last decade. The rapid growth in installed wind power capacity has led to an increased interest in wind energy forecasting. This report discusses the importance of forecasting for wind power industry and reviews state-of-the-art methodologies for forecasting wind energy and output ramp rates. This report also discusses available data sources for validation and calibration and makes recommendations on best practices for wind forecasting and on future research.
- Published
- 2010
4. California Wind Energy Collaborative Final Report
- Author
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van Dam, C.
- Abstract
The California Wind Energy Collaborative supports the development of safe, reliable, environmentally sound, and affordable wind electric generation capacity within the state of California. To fulfill this mission, the Collaborative manages a focused, statewide program of scientific research, technology development & deployment, and technical transfer and outreach. These efforts are conducted in close cooperation with industry, state and federal agencies, and other institutions to maximize the benefits of wind energy resources in California for its citizens. The Collaborative is a partnership between the University of California and the California Energy Commission, established in February 2002. This report summarizes the activities and deliverables for the period from January 2008 through June 2009.
- Published
- 2009
5. Variations du poids et des paramètres métaboliques sous CAB+RPV injectable ou B/F/TAF oral
- Author
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Tan, D., primary, Antinori, A., additional, Eu, B., additional, Puerto, M.J. Galindo, additional, Kinder, C., additional, Sweet, D., additional, Van Dam, C., additional, Sutherland-Phillips, D., additional, Patel, P., additional, and Cazanave, C., additional
- Published
- 2023
- Full Text
- View/download PDF
6. Benefit and Risk Evaluation of Biased μ-Receptor Agonist Oliceridine versus Morphine
- Author
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Dahan, Albert, van Dam, C. Jan, Niesters, Marieke, van Velzen, Monique, Fossler, Michael J., Demitrack, Mark A., and Olofsen, Erik
- Published
- 2020
- Full Text
- View/download PDF
7. Wind Tunnel Experiment of Microjet-Based Flow Control on a Two-Dimensional Wing with Flap
- Author
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van Dam, C. P., primary, Bharath Mothukuri, Sai, additional, Sheida Hosseini, Seyedeh, additional, White, Edward B., additional, Brown, Lisa M., additional, Kutz, Douglas M., additional, and Justiniano, Ezequiel, additional
- Published
- 2022
- Full Text
- View/download PDF
8. Breakthrough in Parent Company Liability Three Shell Defeats, the End of an Era and New Paradigms
- Author
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Van Dam, C., Van Dam, C., Van Dam, C., and Van Dam, C.
- Abstract
Two English and two Dutch cases have recently clarified the (potential) liability of parent companies vis-a-vis third parties in relation to damage caused by their subsidiaries. They concern the decisions of the UK Supreme Court in Vedanta v Lungowe and Okpabi v Shell, the Hague Court of Appeal in Oguru v Shell and the Hague District Court in Milieudefensie v Shell (climate change case).
- Published
- 2021
9. Is This the Real Life? Is This Just Fantasy? Caught in a Landslide, No Escape From Reality
- Author
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Van Dam, C., Van Dam, C., Van Dam, C., and Van Dam, C.
- Published
- 2021
10. Moeheid (chronisch vermoeidheidssyndroom)
- Author
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van Dam, C. S., primary and de Vries, H., additional
- Published
- 2017
- Full Text
- View/download PDF
11. Computational Investigation of Nominally-Orthogonal Pneumatic Active Flow Control for Aircraft High-Lift Systems
- Author
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Hosseini, S. Sheida, van Dam, C. P, and Pandya, Shishir
- Subjects
Aerodynamics ,Aircraft Design, Testing And Performance - Published
- 2018
12. Computational Investigation of Nominally-Orthogonal Pneumatic Active Flow Control for High-Lift Systems
- Author
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Hosseini, Seyedeh Sheida, van Dam, C. P, and Pandya, Shishir A
- Subjects
Systems Analysis And Operations Research ,Fluid Mechanics And Thermodynamics - Abstract
We explore the feasibility of using nominally-orthogonal jets as active aerodynamic load control for multi-element high-lift systems, and whether the nominally-orthogonal jets can offer a variety of performance improvements. These nominally-orthogonal jets inject momentum normal to the airfoil surface near the flap trailing edge, where they create a vortex that entrains flow from the opposing side and change the airfoil circulation. Lift-enhancement opportunities of trailing edge nominally-orthogonal jets have previously been studied by Malavard et al. and Blaylock et al. on single-element airfoils; however, their effect on drag was not thoroughly investigated. In this study, we investigate two- dimensional nominally-orthogonal jet effects on both lift and drag on a two-element airfoil, NLR7301. We utilize Chimera Grid Tools to generate structured curvilinear overset grids, and the Reynolds-averaged Navier-Stokes solver OVERFLOW-2 to solve for the flow field around the airfoil. We perform various computational sensitivity studies on the baseline airfoil without a jet to validate computational results against benchmark experimental data. Using a Chimera overset grid topology, we demonstrate a similar lift-enhancement effect between a nominally-orthogonal jet and a nominally-orthogonal physical tab employed at the same location on the studied airfoil. After we introduce the nominally-orthogonal jet concept, we investigate nominally-orthogonal jets with various momentum coefficient settings, C(sub µ) = 0.00 − 0.04 and present a lift-enhancement relationship ∆C(sub l) ≃ 3.59 (C(sub µ)) for this airfoil. We discuss that utilizing a nominally-orthogonal jet with C(sub µ) = 0.01 can shift the linear region of the lift curve by a ∆C(sub l) = 0.36 for the pressure side jet and by a ∆C(sub l) = −0.27 for the suction side jet. Employing a nominally-orthogonal jet is also shown effective in altering the drag. To study the impact, we carry out a drag decomposition study in the form of drag polars. We show for a given C(sub l) = 2.50, a nominally-orthogonal jet with C(sub µ) = 0.01 on the pressure and suction side of the airfoil results in 113 drag count decrements and 41 drag count increments, respectively, compared to the baseline airfoil with no jet. These results show that large and controllable changes in aerodynamic performance can be achieved by relatively small active flow control inputs using the nominally-orthogonal jets presented in this study.
- Published
- 2018
13. Wind Tunnel Experiment of Microjet-Based Flow Control on a Two-Dimensional Wing with Flap.
- Author
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van Dam, C. P., Mothukuri, Sai Bharath, Hosseini, Seyedeh Sheida, White, Edward B., Brown, Lisa M., Kutz, Douglas M., and Justiniano, Ezequiel
- Published
- 2023
- Full Text
- View/download PDF
14. Wind turbine rotor fragments: impact probability and setback evaluation
- Author
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Larwood, Scott and van Dam, C. P.
- Published
- 2015
- Full Text
- View/download PDF
15. Cost Effectiveness of Splenic Artery Embolization versus Splenectomy after Trauma in the Netherlands
- Author
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Kanters, Tim A., primary, Raaijmakers, Claudia P.A.M., additional, Lohle, Paul N.M., additional, de Vries, Jolanda, additional, Hakkaart-van Roijen, Leona, additional, Raaijmakers, C.P.A.M., additional, Lohle, P.N.M., additional, de Vries, J., additional, van der Heijden, F.H.W.M., additional, Schonenberg, C.H.J., additional, Verhofstad, M.H.J., additional, Moelker, A., additional, de Graaff, H.P., additional, Vroegindeweij, D., additional, van der Vlies, C.H., additional, Smit, K.C., additional, Elgersma, O.E.H., additional, Jakma, T.S.C., additional, Roodenburg, H.S., additional, Vos, L.D., additional, Romme, P.J.H.J., additional, Zielinski, S.M., additional, Alberts, A.R., additional, van der Slegt, J., additional, van Rijswijk, C.S.P., additional, Bartlema, K.A., additional, Labadie, G., additional, Meijerink, M.R., additional, Zuidema, W.P., additional, van Dam, C., additional, Klazen, C.A.H., additional, de Wit, R.J., additional, Goolkate, A., additional, Edwards, M.J.R., additional, Dekker, H.M., additional, Tromp, T., additional, van Hasselt, B.A.A.M., additional, van Helden, S.H., additional, and Buitenhuis, L., additional
- Published
- 2022
- Full Text
- View/download PDF
16. Simulation of Nonlinear Tollmien-Schlichting Wave Growth Through a Laminar Separation Bubble
- Author
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van Dam, C. P., Elli, S., Hussaini, M. Y., editor, Kumar, A., editor, and Streett, C. L., editor
- Published
- 1992
- Full Text
- View/download PDF
17. Unsteady Viscous Flow Calculations Including Surface Heating and Cooling Effects
- Author
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van Dam, C. P., Hafez, M., Brucker, D., Elli, S., Hirschel, Ernst Heinrich, editor, Fujii, Kozo, editor, Morton, Keith William, editor, Murman, Earll M., editor, Pandolfi, Maurizio, editor, Rizzi, Arthur, editor, Roux, Bernard, editor, and Wesseling, Pieter, editor
- Published
- 1990
- Full Text
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18. STD Prevention: Effectively Reaching the Core and a Bridge Population With a Four-Component Intervention
- Author
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VAN DAM, C. JOHANNES and HOLMES, KING K.
- Published
- 2000
19. A Transport Equation Approach to Modeling the Influence of Surface Roughness on Boundary Layer Transition
- Author
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Langel, Christopher, primary, Chow, Raymond, additional, van Dam, C., additional, and Maniaci, David, additional
- Published
- 2017
- Full Text
- View/download PDF
20. RANS Based Methodology for Predicting the Influence of Leading Edge Erosion on Airfoil Performance
- Author
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Langel, Christopher, primary, Chow, Raymond, additional, van Dam, C., additional, and Maniaci, David, additional
- Published
- 2017
- Full Text
- View/download PDF
21. Microjet Configuration Sensitivities for Active Flow Control on Multi-Element High-Lift Systems
- Author
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Hosseini, Seyedeh Sheida, primary, Cooperman, Aubryn, additional, van Dam, C. P., additional, and Pandya, Shishir A., additional
- Published
- 2021
- Full Text
- View/download PDF
22. Mainstreaming Human Rights in Sustainable Business
- Author
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van Dam, C, Tiemersma, Heleen, van Tulder, R., Kaptein, M., Meijs, L., and Civil Law
- Published
- 2018
23. Staatsondernemingen en Mensenrechten
- Author
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van Dam, C, Tiemersma, Heleen, and Civil Law
- Published
- 2018
24. Aerodynamic Load Control for Multi-Element Airfoils Using Surface-Normal Trailing-Edge Blowing
- Author
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Hosseini, Seyedeh Sheida, primary, van Dam, C. P., additional, and Pandya, Shishir A., additional
- Published
- 2019
- Full Text
- View/download PDF
25. Microjets for Lift Enhancement and Separation Mitigation in High-Lift Systems
- Author
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Hosseini, Seyedeh Sheida, primary, Cooperman, Aubryn, additional, van Dam, C. P., additional, and Pandya, Shishir A., additional
- Published
- 2019
- Full Text
- View/download PDF
26. Blade Element Momentum Study of Rotor Aerodynamic Performance and Loading for Active and Passive Microjet Systems
- Author
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Hurley, Owen F., primary, Chow, Raymond, additional, Blaylock, Myra L., additional, Cooperman, Aubryn M., additional, and van Dam, C. P., additional
- Published
- 2019
- Full Text
- View/download PDF
27. Syndromic approach to STD case management: where do we go from here?
- Author
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van Dam, C Johannes, Becker, Karen M, Ndowa, Francis, and Islam, Monir Q
- Published
- 1998
28. Syndromic management of genital ulcer disease--a reply
- Author
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Van Dam, C. Johannes
- Published
- 1996
29. Two-dimensional computational analysis of a transport high-lift system and a comparison with flight-test results
- Author
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Hardin, Jay D, Potter, R. C, Van Dam, C. P, and Yip, Long P
- Subjects
Aerodynamics - Abstract
Two currently available coupled inviscid/viscous multielement computational codes, including a relatively simple panel method and an Euler method, are used to analyze a high-lift system. The results are compared with two-dimensional wind-tunnel test results and then with the three-dimensional flight-test results obtained from the NASA Langley Transport Systems Research Vehicle five-element high-lift wing section. Comparisons were also made between the panel method, the Euler method, and flight data for two high-lift configurations, one representing a take-off configuration and the other an approach configuration. For the take-off configuration, both codes agreed reasonably well with experimental data, but both codes were found to overpredict the flap upper-surface pressures for the approach configuration.
- Published
- 1993
30. Shape optimization for aerodynamic efficiency and low observability
- Author
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Vinh, Hoang, Van Dam, C. P, and Dwyer, Harry A
- Subjects
Aerodynamics - Abstract
Field methods based on the finite-difference approximations of the time-domain Maxwell's equations and the potential-flow equation have been developed to solve the multidisciplinary problem of airfoil shaping for aerodynamic efficiency and low radar cross section (RCS). A parametric study and an optimization study employing the two analysis methods are presented to illustrate their combined capabilities. The parametric study shows that for frontal radar illumination, the RCS of an airfoil is independent of the chordwise location of maximum thickness but depends strongly on the maximum thickness, leading-edge radius, and leadingedge shape. In addition, this study shows that the RCS of an airfoil can be reduced without significant effects on its transonic aerodynamic efficiency by reducing the leading-edge radius and/or modifying the shape of the leading edge. The optimization study involves the minimization of wave drag for a non-lifting, symmetrical airfoil with constraints on the airfoil maximum thickness and monostatic RCS. This optimization study shows that the two analysis methods can be used effectively to design aerodynamically efficient airfoils with certain desired RCS characteristics.
- Published
- 1993
31. Leading-edge transition and relaminarization phenomena on a subsonic high-lift system
- Author
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Van Dam, C. P, Vijgen, P. M. H. W, Yip, L. P, and Potter, R. C
- Subjects
Aerodynamics - Abstract
Boundary-layer transition and relaminarization may have a critical effect on the flow development about multielement high-lift systems of subsonic transport aircraft with swept wings. The purpose of this paper is a study of transition phenomena in the leading-edge region of the various elements of a high-lift system. The flow phenomena studied include transition of the attachment-line flow, relaminarization, and crossflow instability. The calculations are based on pressure distributions measured in flight on the NASA Transport Systems Research Vehicle (Boeing 737-100) at a wing station where the flow approximated infinite swept wing conditions. The results indicate that significant regions of laminar flow can exist on all flap elements in flight. In future flight experiments the extent of these regions will be measured, and the transition mechanisms and the effect of laminar flow on the high-lift characteristics of the multi-element system will be further explored.
- Published
- 1993
32. Accurate drag prediction: A prerequisite for drag reduction research
- Author
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Wong, Kent J, Ayers, Tricia K, and Van Dam, C. P
- Subjects
Aerodynamics - Abstract
An improved technique for drag prediction based on the analysis of wake flows is presented and demonstrated. The technique is demonstrated using three-dimensional flow field solutions obtained with several Euler codes. The flow field solutions are obtained for several wing configurations at both lifting and nonlifting conditions for a range of speeds. At subsonic speeds, the induced-drag prediction is shown to be more accurate (and virtually independent of numerical viscosity levels in the Euler flow field solutions) than the prediction obtained by surface integration. At transonic speeds, a separate wave-drag prediction procedure allows the decomposition of the total inviscid drag into wave drag and induced drag. Preliminary results indicate that the drag-prediction technique in a slightly revised form may be applicable to predict induced drag and wave drag at supersonic speeds.
- Published
- 1993
33. Active load control techniques for wind turbines.
- Author
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van Dam, C, primary, Berg, Dale, additional, and Johnson, Scott, additional
- Published
- 2008
- Full Text
- View/download PDF
34. Finite-difference algorithms for the time-domain Maxwell's equations - A numerical approach to RCS analysis
- Author
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Vinh, Hoang, Dwyer, Harry A, and Van Dam, C. P
- Subjects
Communications And Radar - Abstract
The applications of two CFD-based finite-difference methods to computational electromagnetics are investigated. In the first method, the time-domain Maxwell's equations are solved using the explicit Lax-Wendroff scheme and in the second method, the second-order wave equations satisfying the Maxwell's equations are solved using the implicit Crank-Nicolson scheme. The governing equations are transformed to a generalized curvilinear coordinate system and solved on a body-conforming mesh using the scattered-field formulation. The induced surface current and the bistatic radar cross section are computed and the results are validated for several two-dimensional test cases involving perfectly-conducting scatterers submerged in transverse-magnetic plane waves.
- Published
- 1992
35. Flatback airfoil wind tunnel experiment.
- Author
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Mayda, Edward, primary, van Dam, C, additional, Chao, David, additional, and Berg, Dale, additional
- Published
- 2008
- Full Text
- View/download PDF
36. CFD analysis of rotating two-bladed flatback wind turbine rotor.
- Author
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van Dam, C, primary, Chao, David, additional, and Berg, Dale, additional
- Published
- 2008
- Full Text
- View/download PDF
37. Trailing edge modifications for flatback airfoils.
- Author
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Kahn, Daniel, primary, van Dam, C, additional, and Berg, Dale, additional
- Published
- 2008
- Full Text
- View/download PDF
38. Computational design and analysis of flatback airfoil wind tunnel experiment.
- Author
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Mayda, Edward, primary, van Dam, C, additional, Chao, David, additional, and Berg, Dale, additional
- Published
- 2008
- Full Text
- View/download PDF
39. Subsonic and transonic low-Reynolds-number airfoils with reduced pitching moments
- Author
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Reuther, J, Van Dam, C. P, and Hicks, R
- Subjects
Aerodynamics - Published
- 1992
40. Accurate prediction of drag using Euler methods
- Author
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Van Dam, C. P and Nikfetrat, K
- Subjects
Aerodynamics - Published
- 1992
41. Prediction of drag at subsonic and transonic speeds using Euler methods
- Author
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Nikfetrat, K, Van Dam, C. P, Vijgen, P. M. H. W, and Chang, I. C
- Subjects
Aerodynamics - Abstract
A technique for the evaluation of aerodynamic drag from flowfield solutions based on the Euler equations is discussed. The technique is limited to steady attached flows around three-dimensional configurations in the absence of active systems such as surface blowing/suction and propulsion. It allows the decomposition of the total drag into induced drag and wave drag and, consequently, it provides more information on the drag sources than the conventional surface-pressure integration technique. The induced drag is obtained from the integration of the kinetic energy (per unit distance) of the trailing vortex system on a wake plane and the wave drag is obtained from the integration of the entropy production on a plane just downstream of the shocks. The drag-evaluation technique is applied to three-dimensional flowfield solutions for the ONERA M6 wing as well as an aspect-ratio-7 wing with an elliptic spanwise chord distribution and an NACA-0012 section shape. Comparisons between the drag obtained with the present technique and the drag based on the integration of surface pressures are presented for two Euler codes.
- Published
- 1992
42. Subsonic high-lift flight research on the NASA Transport System Research Vehicle (TSRV)
- Author
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Yip, Long P, Vijgen, Paul M. H. W, Hardin, Jay D, and Van Dam, C. P
- Subjects
Aircraft Design, Testing And Performance - Abstract
Flight tests are being conducted as part of a multiphased subsonic transport high-lift research project for correlation with ground based wind tunnel and computational results. The NASA Langley TSRV 737-100 airplane is utilized to obtain flow characteristics at full-scale Reynolds numbers to contribute to the knowledge of several dominant high-lift flow issues such as boundary layer transition, confluent boundary layer development, and 3D flow separation. Recent test results obtained for a full-chord wing section including the slat, main-wing, and flap elements are presented.
- Published
- 1992
43. Practical design optimization of wing/body configurations using the Euler equations
- Author
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Reuther, J, Cliff, S. E, Hicks, R. M, and Van Dam, C. P
- Subjects
Aerodynamics - Abstract
The development of a practical method for the aerodynamic design of isolated wing and wing/body configurations is achieved through the coupling of existing computational fluid dynamics (CFD) analysis codes and a quasi-Newton numerical optimization method. The direct design method is generalized to treat three-dimensional aerodynamic optimization problems subject to inviscid, rotational, compressible flow conditions imposed by the Euler equations. The method couples either the FLO57 or the TEAM flow solver with a modified version of the QNMDIF numerical optimization algorithm. The method is applied, but is not limited, to supersonic design problems. A case study is presented illustrating the method's effectiveness in maximizing the lift-to-drag ratio, subject to a variety of constraints, of selected supersonic configurations at cruise conditions.
- Published
- 1992
44. Experimental investigation on the effect of crescent planform on lift and drag
- Author
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Van Dam, C. P, Vijgen, P. M. H. W, and Holmes, B. J
- Subjects
Aerodynamics - Published
- 1991
45. Wing design code using three-dimensional Euler equations and optimization
- Author
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Chang, I-Chung, Torres, Francisco J, and Van Dam, C. P
- Subjects
Aerodynamics - Abstract
This paper describes a new wing design code which is based on the Euler equations and a constrained numerical optimization technique. The geometry modification is based on a set of fundamental modes define on the unit interval. A design example involving a high speed civil transport wing is presented to demonstrate the usefulness of the design code. It is shown that the use of an Euler solver in the direct numerical optimization procedures is affordable on the current generation of supercomputers.
- Published
- 1991
46. Aerodynamic characteristics of crescent and elliptic wings at high angles of attack
- Author
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Van Dam, C. P, Vijgen, P. M. H. W, and Holmes, B. J
- Subjects
Aerodynamics - Published
- 1991
47. Drag calculations of wings using Euler methods
- Author
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Van Dam, C. P, Chang, I. C, Vijgen, P. M. H. W, and Nikfetrat, Koorosh
- Subjects
Aerodynamics - Abstract
Several techniques for the calculation of drag using Euler-equation formulations are discussed and compared. Surface-pressure integration (a nearfield technique) as well as two different farfield calculation techniques are described and applied to three-dimensional flow-field solutions for an aspect-ratio-7 wing with attached flow. The present calculations are limited to steady, low-Mach-number flows around three-dimensional configurations in the absence of active systems such as surface blowing/suction and propulsion. Although the main focus of the paper is the calculation of aerodynamic drag, the calculation of aerodynamic lift is also briefly discussed. Three Euler methods are used to obtain the flowfield solutions. The farfield technique based on the evaluation of a wake-integral appears to provide the most consistent and accurate drag predictions.
- Published
- 1991
48. Ezetimibe added to statin therapy after acute coronary syndromes
- Author
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Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, Califf, Musliner T, Robert M., Tershakovec, A, Gurfinkel, E, Aylward, P, Tonkin, A, Maurer, G, Van de Werf, F, Nicolau, Jc, Theroux, P, Genest, J, Armstrong, P, Corbalan, R, Isaza, D, Spinar, J, Grande, P, Voitk, J, Kesaniemi, A, Bassand, Jp, Farnier, M, Darius, H, Keltai, M, Mathur, A, Mittal, S, Reddy, K, Lewis, B, De Ferrari GM, Ophuis, To, Jukema, J, White, H, Pedersen, T, Britto, F, Ruzyllo, W, Carrageta, M, Duris, T, Dalby, A, Seung, Kb, Lopez-Sendon, J, Dellborg, M, Mach, F, Guneri, S, Parkhomenko, A, Brady, A, Cannon, C, Blazing, M, Ballantyne, C, de Lemos, J, Kleiman, N, Mcguire, Dk, Centeno, E, Casalins, M, Cartasegna, L, Beltrano, Mc, Guerrero, R, Fanuele, M, Berra, F, Egido, J, Colombo, H, Dellatorre, M, Terns, P, Blumberg, E, Reges, P, Azize, G, Ramos, H, Fernandez, R, Carlessi, C, Milesi, R, Schmuck, R, Duronto, E, Procopio, G, Carlevaro, O, Maffeo, H, Beloscar, J, Viso, M, Hominal, M, Castoldi, M, Bluguermann, J, Mauro, D, Macin, S, Cocco, N, Ruiz, N, Ricart, J, Lozada, A, Nani, S, Turri, D, Fernandez, H, Caruso, O, Zarandon, R, Bono, J, Arias, V, Allall, O, Marino, J, Cusimano, S, Schygiel, P, Buzetti, C, Penaloza, N, Berli, M, Worthley, S, Roach, A, Chew, D, Wright, T, Leitch, J, Hicks, E, Rankin, J, Venn-Edmonds, C, Lehman, R, Morrison, H, Shaw, J, Mak, V, Hii, C, Smith, K, Cross, D, Lilwall, L, Nelson, G, Loxton, A, Horowitz, J, Rose, J, Steinwender, C, Leisch, F, Kammler, J, Brussee, H, Zweiker, R, Niederl, E, Weihs, W, Giorgio, G, Lang, I, Drexel, H, Zanolin, D, Hoppe, U, Atzenhofer-Baumgartner, K, Pichler, M, Hainzer, D, Eber, B, Pichler, F, Foeger, B, Wechselberger, T, Mayr, H, Hofer, J, Stockenhuber, F, Warlits, B, Huber, K, Egger, F, Weidinger, F, Ziegler, B, Jirak, P, Metzler, B, Pachinger, O, Wanitschek, M, Auer, J, Grabscheit, G, Podczeck-Schweighofer, A, Priesnitz, T, Frank, H, El Allaf, D, Marechal, P, Roosen, J, Joly, E, Lefebvre, P, Arend, C, Sinnaeve, P, De Velder, L, Hellemans, S, Vanhauwaert, B, Van Dorpe, A, Heyse, A, Vantomme, C, Striekwold, H, Van Den Broeck, D, Lancellotti, P, Schoors, D, Lemoine, I, Taeymans, Y, De Wolf, L, Brike, C, Vercauteren, S, Tahon, S, Vervoort, G, Mestdagh, I, Pirenne, B, Cardinal, F, Lips, S, Dujardin, K, Debrouwer, K, Dhooghe, G, Holvoet, G, van de Borne, P, Renard, M, De Clippel, M, Lesseliers, H, Van Miert, N, Saraiva, J, Vicente, C, Rossi, P, Dos Santos LB, Duda, N, Tognon, Ap, Serrano, C, Gomes, Fl, Manenti, Er, Silveira, Ds, Maia, L, Mouco, Om, Paiva, M, Antonangelo, A, de Souza, J, Lino, Ea, Leães, P, Blacher, Mg, Kormann, A, Ultramari, Ft, Dutra, O, Mendelski, Am, Morgado, S, Ardito, W, Greque, G, Ardito, Rv, Pimentel Filho, P, Zucchetti, C, Alves, A, Seabra, Am, Mattos, M, Miranda, Lf, Silva, D, Uehara, Rm, Marin Neto, J, Schmidt, A, Braga, J, Rodrigues, A, 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Esplugas, E., Gonzalez, J., de Sa, E., Armada, E., Worner, F., Hernández, I., Roncales, F., Gomollon, J., del Rio, A., Alameda, J., Basilio, E., Rafols, M., Ferres, R., Molla, C., Pascual, J., Cortada, J., García, C., Iglesias, G., Villa, E., Aros, F., Goya, I., Bueno, M., Pereira, R.V., Clavero, X., Pasaron, C.D., Jorda, R., Pereira, R., Perez, O., de Teresa, E., Navarro, M., de la Guia, F., Lozano, T., Antorrena, I., Aranda, M., Alonso, L., Mirelis, J., Alcasena, S., Paniagua, V.A., Juanatey, J., Gregorian, L., Munoz, J., Escorihuela, A., Sanz, A., Flores, A., Garcia, P.A., Alfonso, F., Marin, E., Lozano, A., Bethencourt, A., Grau, A., Rubio, A., Sala, J., Royuela, N., San Jose, J., Bugos, V., de Valdecilla, H., Martin, J., Jimenez, R., Felgueres, M., Escalera, P., Ruiz, R., Bescos, L., Sanchez, I., Chavarri, M., Casares, G., Johanson, P., Hultsberg-Olsson, G., Witt, N., Samad, B., Damm, T., Risenfors, M., Ortgren, L., Henareh, L., Jernberg, T., Berglund, M., Karlsson, J., Koch, A., 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Chian-Yi, W., Yeh, H., Mei-Juan, C., Hsieh, I., Wang, Y., Ural, E., Sahin, T., Yildiz, Z., Kayikcioglu, M., Kultursay, H., Yigit, Z., Calpar, I., Ata, N., Goktekin, O., Senol, U., Yalcin, R., Timurkaynak, T., Kaya, U., Yildirir, A., Karacaglar, E., Faynyk, A., Sorokivskyy, M., Koval, O., Kaplan, P., Kraiz, I., Popova, K., Kyyak, Y., Barnett, O., Karpenko, O., Todoriuk, L., Tseluyko, V., Kopytsya, M., Petyunina, O., Kovalskyy, I., Zhukova, Y., Katerenchuk, I., M'yakinkova, L., Lutay, Y., Syvolap, V., Kyselov, S., Vakaliuk, I., Nesterak, R., Nikonov, V., Feskov, O., Goloborodko, B., Golovtsev, Y., Berezniakov, I., Lebedynska, M., Rudenko, L., Tutov, I., Ahsan, A., Burton, J., Levy, T., Lakeman, N., Spratt, J., Langford, E., Sutcliffe, S., Khwanda, A., Davis, G., Rodrigues, E., Dickinson, D., Been, M., Trouton, T., Riddell, J., Moriarty, A., McEneaney, D., Squire, I., Narayan, H., Goode, G., Helliwell, L., Boos, C., Greaves, K., Knops, K., Pegge, N., Signy, M., Wong, Y., Moore, S., Fluck, D., Atkinson, C., Adgey, A., McKeag, N., Bishop, A., Glover, J., Barbir, M., Breen, J., Robson, H., Townend, J., Dwenger, E., Ekpo, E., Shakespeare, C., Barr, C., McClements, B., McAllister, A., De Belder, M., Cooke, J., Williams, S., Daniel, D., Pye, M., Griffith, K., Wright, L., Trevelyan, J., Doughty, A., Hughes, E., Phillips, C., Penny, W., Groves, P., Kardos, A., Purvis, J., McNeill, A., Jones, A., Brown, J., Saeed, B., Sprigings, D., Herity, N., Brown, C., Unks, M., Cauthren, T., Bertolet, B., Jones, M., Decker, S., Chambers, J., Stahlberg, J., Varma, S., Gencheff, N., Price, A., McElroy, D., Chu, A., Crutchfield, B., Eaton, G., Looney, A., Qureshi, M., Wilks, J., Drenning, D., Overman, A., Andreou, C., Russo, P., Stuckey, T., Pruitt, H., D'Urso, M., DeRaad, R., Rogers, W., Thorington, S., Pasquini, J., Iwaoka, R., Tannenbaum, M., Prouty, D., Wiseman, A., Sharow, A., Graham, B., Ali, M.I., Dale, H., Tarsi, D., Picone, M., Juarez, S., Hamroff, G., Hollenweger, L., Scirica, B., Sabatine, M., Marti, J., Perlman, R., Pavlides, A., Joffe, I., Albirini, A., Campbell, T., Puri, S., Lopez, C., Pearce, D., Shah, D., McPherson, J., Donegan, R., Murdock, D., Block, D., Malik, A., Musina, R., Dauber, I., Varner, C., Bach, R., Palazzolo, M., Bhalla, H., Thompson, M., Pollock, S., Johnson, S., Lipson, L., Brunk, S., Karas, S., Vicari, R., Kuvin, J., Mooney, P., Aycock, G., Lane, B., Sharma, M., Gibson, T., Chang, G., DiVito, P., Mehta, R., Watkins, K., Chiu, A., Gunderson, J., Tedder, B., Williams, P., Hage-Korban, E., Childs, A., Banerjee, S., Kazi, F., Bennett, J., Barnes, D., Wohns, D., Noorman, C., Aggarwal, K., Lau-Sickman, A., Paulowski, J., Amos, M., Rider, J., Fenton, S., Schantz, M., Hakas, J., Mcsorley, J., Felten, W., Bitzer, V., Russell, J., Loyo, J., Adjei, A., Mehta, K., Uretsky, B., Hale, M., Shaikh, S., Miller, M., Hollenbaugh, D., Crawford, K., Fortuin, D., Galindo, A., Del Core, M., Butkus, E., Collins, J., Prior, J., Hahn, R., Greene-Nashold, J., Alexander, J., Genova, E., MacDonell, A., Broadwater, S., Kereiakes, D., White, D., Lopez, M., Schenks, R., Lui, H., Gibbons, P., Davis, B., Thornton, K., Daley, P., Budzon, S., McCullum, K., Delio-Cox, B., Nadar, V., Keim, S., McLaurin, B., Davis, C., Betzu, R., Al-Jumaily, J., Bolli, R., Alshaher, M., Leesar, M., Collins, T., Akkad, H., Bilazarian, S., Marsters, M., Kennett, J., Melegrito, K., Mostel, E., Harris, R., Chang, M., Hatfield, G., Makam, S., Garvey, M., Levite, H., White, J., Abdel-Latief, A., Pelletier, L., Carr, K., Mckenna, K., De Lemos, J., Soto, G., Kozina, J., Harris, D., Vlastaris, A., Bittel, B., Riba, A., Gugudis, J., Singh, N., Qureshi, I., Doty, W., Lehmann, J., Lieber, I., Martin, S., Nicu, M., Bhalodkar, N., Ravi, P., Canto, J., Bass, M., Campbell, C., Steinhubl, S., Moles, K., Harjai, K., Stapleton, D.D., Hoey, K., Erwin, J., Fikes, W., Stein, B., Sabatino, K., Teklinski, A., Colfer, H., Ward, P., Langevin, E., Faucett, S., Mamdani, S., DeSimone, L., Tuohy, E., Cullen, T., Eisenberg, S., Chronos, N., Allen, R.P., Erickson, B., Mahon, K., Kirby, A., Siegel, C., Stroud, L., Johnson, J., Panchal, V., Pearson, A., Abell, T., De Gregorio, M., Boomer, L., Vahdat, O., VanNatta, B., Long, P., Chalavarya, G., Skatrud, L., Carey, C., Wright, W., Mechem, C., Matthews, B., Adams, A., Vora, K., Wead, J., Koren, M., Gregory, D., El Khadra, M., Peacock, G., Kieval, J., Barron, M., Lewis, D., Grice, R., Bobek, M., Moore, C., Nygaard, T., Fischell, T., Salman, W., Schneider, C., Muhlestein, B., Peeler, D., Chang, D., Todd, A., Chilakamarri, V., Hanley, P., Gelormini, J., Iacona, M.A., Effron, B., Mazzurco, S., Mazzella, M., Wyman, P., Orchard, R., Battin, D., Rezkalla, S., Bishop, C., Sharp, S., Gredler, F., Knap, P., Fadel, M., Saucedo, J., Keng, A., Imburgia, M., Blank, E., Effat, M., Khoury, S., Mardis, R., Baldari, D., Tafuri, L., Mascolo, R., Taylor, D., Mandviwala, M., Khan, W., Mumford, T., Mayer, N., Mitchell, B., Oliver, T., Lombardi, W., Zimmerman, T., Rohrbeck, S., Cooke, L., Craig, M., Mego, D., Griffin, B., Perez, J., LeClerc, K., Addington, J., Aboufakher, R., Ahmed, A., Westecott, B., Steel, K., Hawkins, K., Shah, A., Ward, U., McGreevy, M., Goldberg, R., Prashad, R., McDonough, C., Silver, K., Josephson, R., Witsaman, S., Labib, S., Woodhead, G., Schrank, J., Bell, K., Chandna, H., Holly, D., Bethea, C., Fife, B., Gruberg, L., Singer, A., Ramgadoo, M., Lalonde, T., Morin, R., French, W., Barillas, O., Gradner, G., Kahn, Z., Gress, J., Rocco, D., Thew, S., Stifter, W., Fisher, M., McNamara, J., Kupfer, J., Agocha, A., Cush, S., Jones, S., Whitaker, T., Stover, T., Kumkumian, G., Kent, K., Greenberg, A., Pandey, P., Pytlewski, G., Matsumura, M., Kai, W., Sameshima, S., Thomas, J., MacNicholas, D., Pillai, K., Jones, D., Navas, J.P., Laskoe, B., Patel, P., Fini, G., Minor, S., Shipwash, T., Cabrera-Santamaria, A., Rivera, E., Mincher, L., Jafar, M., Yen, M., Finkle, C., Rahimtoola, A., Severson, L., Labroo, A., Jinich, D., Tam, K., Vogel, C., Aggarwal, R., Zakhary, B., Curtis, S., Lyster, M., Humphrey, K., Lavine, P., Fujise, K., Birnbaum, Y., Allen, J., Kesselbrenner, M., Michel, K., Staniloae, C., Liu, M., Sonel, A., Macioce-Caffas, A., Amidon, T., Leggett, J., Yedinak, S., Gudmundsson, G., Sabharwal, J., Dagefoerde, N., Wu, W., Meyerrose, G., Roongsritong, C., Jenkins, L., Lieberman, S., Sokol, S., Gutierrez, C., Nelson, C., Barrett, J., Hotchkiss, D., Farley, A., Atassi, K., Christy, L., Baig, M., Di Fazio, J., Meengs, M., Thomas, K., Surmitis, J., DeVault, S., Farhat, N., Hulyalkar, A., Riddell, L., Rivera, W., Sheynberg, B., Kobayashi, J., Katsaropoulos, J., Jan, M., Krucoff, M., Paterno, C., Chandrasekaran, S., Curry, R., Cassavar, D., Wheeler, M., McGarvey, J., Schwarz, L., Miller, E., Andrea, B., Carswell, B.S., Lurie, M., Patti, J., Bowden, W., Vasiliauskas, T., Latham, R., Schwartz, B., Bradford, L., Mattleman, S., Wertheimer, J., Goulden, D., Khan, M., Hawkins, B., Ostfeld, R., Mueller, H., Ash, Y., Wilson, V., Bayer, M., Marshall, J., Dobies, D., Dawson, G., Osman, A., Saba, F., Costello, T., Fuentes, F., Underwood, C., Vijay, N., Washam, M., Dietz, W., Glasgow, B., Mukherjee, S., Hinchion, N., Speirs, S., Thornley, A., Lee, K., Movahed, M., Strootman, D., Chernick, R., Parrott, C., Flock, C., Marques, V., Syzmanski, E., Rama, P., Domingo, D., Wu, L., Bauer, B., Dionisopoulos, P., Aggarwal, A., Holcomb, R., Foster, R., Hancock, T., Hargrove, J., Fletcher, A., Stine, R., Bullivant, M., Adams, K., Lohman, J., Klepper, V., Kabour, A., Neidhardt, J., Phillips, W., Tardiff, S., Aji, J., Corut, S., Foster, G., Firek, C., St Goar, F., Sumner, R., Davis, T., Schneider, R., Schneider, W., Villa, A., Desai, V., Chhabra, A., Banks, K., Herzog, W., Burley, T., Quyyumi, A., Smiley, W., Manocha, P., Fishbein, G., Weller, C., Coffman, A., Kim, C., Kedia, A., Firth, B., Rizvi, M., Dahiya, R., Foster, B., Balcells, E., Metzger, D.C., Lester, J., Bissett, J., Fahdi, I., Sides, E.A., Azrin, M., Martin, C., Quick, A., Conaway, D., Garg, M., Schallert, G., Lancaster, L., Mckissick, S., Atieh, M., Garbarino, J., Eisenberg, D., Uusinarkaus, K., Wirtemburg, P., Ellis, J., Cristaldi, J., Berglund, R., Negus, B., Pappas, J., Rocha, R., Nguyen, T., Stone, J., Janosik, D., Labovitz, A., Elmore, N., Dave, R., Loffredo, K., Gabriel, G., Snyder, C., Ahmed, O., Stone, H., Kelley, M., Diffenback, M., Friedman, B., Zirkle, J., Severa, L., Sample, S., Dignen, K., Raisinghani, A., Ben-Yehuda, O., Ghannadian, B., Moscoso, R., Mankowski, J., Boliek, W., Rukavina, M., Davis, W., Ledbetter, S., Handel, F., Mastouri, R., Mahenthiran, J., Foltz, J., Malhotra, V., Jonas, J., Berk, M., Singh, V., Nelson, M., Elsner, G., Gall, J., Kondo, N., Frank, S., Chandraratna, P., Ranasinghe, S., Ebrahimi, R., Treadwell, M., Walters, B., Hughes, L., Kramer, J., Kumar, K., Mente, T., Lachterman, B., Schifferdecker, B., Munshi, K., Sease, D., Waldo, D., Chandler, G., Manns, D., Nahhas, A., Kamalesh, M., Williams, V., Reich, D., Desalca, M., Sharma, S., Liston, M., Gupta, K., Costa, M., Altschuller, A., Lemmertz, K., Shanes, J., Hansen, C., Therrien, M., Mendelson, R., Ramnarine, R., Myers, G., Donovan, C., Klein, M., Fine, D., Owens, S., Murray, C., Ketroser, R., Heifetz, S., Darnell, Z., Touchon, R., Taghizadeh, B., Bohle, D., Norwood, D., Forrest, T., Jackson, S., Shumate, K., Bayles, A., Masroor, M., North, W.K., Fishberg, R., Merveil-Ceneus, B., Butcher, R., Menapace, F., Kilbride, S., Ramabadran, R.S., Loukinen, K., Khalil, J., Ramabadran, R., Walsh, S., Gill, S., Cyncar, R., McLachlan, J., Surakanti, V., Rusterholtz, L., Shoukfeh, F., Stephenson, L., Tsang, M., Nolan, V., Gilchrist, I., Jefferson, D., Feldman, T., Reyes, L., Santos, R., Little, W., Wesley, D., Gharib, W., Mendell, A., Esham, G., Kakavas, P., Whitcomb, C., Book, K., Bazzi, A., Alvarez, J., Cohen, Y., Ayres, T., Rhule, V., Labib, A., Schuler, P., Zughaib, M., Telck, K., Bikkina, M., Turnbull, K., Sharma, T., Orosz, S., Shah, R., Petrino, M., Hughes, M., Hershey, J., Hudock, D., Hui, P., Von Bakonyi, A., Arnold, A., Kappel, D., Pennock, G., Cloud, B., Tucker, K., Harp, L., Hoover, C., Eisenhauer, M., Roth, J., Young, C., Thai, H., Escalante, A., Bautista, J., Gazmuri, R., Nyland, J., Cubeddu, L., DeFranco, A., Dias, D., Fielding, M., Reeves, R., Hermany, P., Meissner-Dengler, S., Evans, M., Flores, E., Tannenbaum, A., McGarr, K., Moran, J., Stout, E., Allred, S., Henderson, D., Crandall, L., Strote, J., Voyles, W., Robeson, D., Bedoya, R., Omar, B., Pettyjohn, F., Revere, C., Coy, K., Margolis, J., Sotolongo, C., Scheffel, M., Munir, A., Shirwany, A., Douglas, L., Girala, R., Humphreys, R., Agarwal, J., Bankowski, D., Watson, R., Bishop, B., Klementowicz, P., Blais, D., Cohen, B., Lobur, E., Dimenna, J., Dempsey, K., Izzo, M., Bondi, L., Carell, E., Eaton, C., Saltiel, F., Grewal, G., Connolly, T., Little, T., Wiegman, P., Gips, S., Held, J., Paraschos, A., Quesada, R., Goudreau, E., Sears, M., Istfan, P., Holt, S., McClung, J., Nguyen, N., Quintana, O., Gottlieb, D., Knutson, T., Barringhaus, K., Lester, F., Sullivan, P., Rodriguez-Ospina, L., Cannon, Cp, Blazing, Ma, Giugliano, Rp, Mccagg, A, White, Ja, Theroux, P, Darius, H, Lewis, B, Ophuis, To, Jukema, Jw, De Ferrari, Gm, Ruzyllo, W, De Lucca, P, Im, K, Bohula, Ea, Reist, C, Wiviott, Sd, Tershakovec, Am, Musliner, Ta, Braunwald, E, Califf, Rm, for the IMPROVE-IT, Investigator, Cianflone, D, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], College of Information Science and Engineering, Ritsumeikan University, Montreal Heart Institute (MONTREAL HEART INSTITUTE), Laboratoire des Micro-algues toxiques, Institut Louis Malardé [Papeete] (ILM), Institut de Recherche pour le Développement (IRD)-Institut de Recherche pour le Développement (IRD), Interuniversity Cardiology Institute Netherlands, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Merck Sharp & Dohme Corp., Merck & Co. Inc, DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche, Cannon, C.P., Blazing, M.A., Giugliano, R.P., Mccagg, A., White, J.A., Lewis, B.S., Jukema, J.W., De Lucca, P., Im, K., Bohula, E.A., Reist, C., Wiviott, S.D., Tershakovec, A.M., Musliner, T.A., Braunwald, E., Califf, R.M., for the IMPROVE-IT Investigators [.., C. Rapezzi, ], Other departments, Cannon, Christopher P, Blazing, Michael A., Giugliano, Robert P., Mccagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Kyungah, Im, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.
- Subjects
Male ,Simvastatin ,acute coronary syndrome ,aged ,anticholesteremic agents ,azetidines ,cardiovascular diseases ,cholesterol, ldl ,double-blind method ,drug therapy, combination ,ezetimibe ,female ,humans ,hydroxymethylglutaryl-coa reductase inhibitors ,kaplan-meier estimate ,male ,middle aged ,simvastatin ,triglycerides ,medicine (all ,[SDV]Life Sciences [q-bio] ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Bococizumab ,Triglyceride ,chemistry.chemical_compound ,0302 clinical medicine ,Azetidine ,Cardiovascular Disease ,Anticholesteremic Agent ,Acute Coronary Syndrome ,Aged ,Anticholesteremic Agents ,Azetidines ,Cardiovascular Diseases ,Cholesterol, LDL ,Double-Blind Method ,Drug Therapy, Combination ,Female ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Middle Aged ,Triglycerides ,030212 general & internal medicine ,Medicine (all) ,Research Support, Non-U.S. Gov't ,Hazard ratio ,General Medicine ,Acute Coronary Syndrome, Aged ,Anticholesteremic Agents, Azetidines, Cardiovascular Diseases ,Ezetimibe, Female, Humans ,Male, Middle Aged ,3. Good health ,Multicenter Study ,Editorial ,Cholesterol ,Randomized Controlled Trial ,Combination ,Ezetimibe ,lipids (amino acids, peptides, and proteins) ,Human ,medicine.drug ,medicine.medical_specialty ,Acute Coronary Syndroms ,Urology ,Acute Coronary Syndrome/drug therapy ,Anticholesteremic Agents/adverse effects ,Anticholesteremic Agents/therapeutic use ,Azetidines/adverse effects ,Azetidines/therapeutic use ,Cardiovascular Diseases/epidemiology ,Cardiovascular Diseases/mortality ,Cardiovascular Diseases/prevention & control ,Cholesterol, LDL/blood ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ,Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ,Simvastatin/therapeutic use ,Triglycerides/blood ,NO ,LDL ,03 medical and health sciences ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,Drug Therapy ,Internal medicine ,Journal Article ,medicine ,Comparative Study ,Alirocumab ,business.industry ,PCSK9 ,ta3121 ,Lomitapide ,DOENÇAS CARDIOVASCULARES ,Endocrinology ,chemistry ,Statin Therapy ,Hydroxymethylglutaryl-CoA Reductase Inhibitor ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known.METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization (≥30 days after randomization), or nonfatal stroke. The median follow-up was 6 years.RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (PCONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit. (Funded by Merck; IMPROVE-IT ClinicalTrials.gov number, NCT00202878.).
- Published
- 2015
49. Subsonic and transonic low-Reynolds-number airfoils with reduced pitching moments
- Author
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Van Dam, C. P, Hicks, R, and Reuther, J
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Aerodynamics - Abstract
A subsonic and a transonic airfoil are presented for application in a high-altitude long-endurance aircraft and a very-high-altitude aircraft, respectively. The subsonic airfoil is designed for a lift coefficient c(l) = 1.4 at a chord Reynolds number Re = 700,000 and a very low Mach number. The transonic airfoil is designed for c(l) = 1.0 at Re = 500,000 and a transonic Mach number M = 0.7. Both airfoils are developed to perform as well or better than previously designed airfoils. However, the present airfoils are developed for a constrained pitching moment to reduce aircraft trim drag and to relieve, to some extent, the torsional loads in the typically high-aspect-ratio wings. The beneficial effects of a cruise flap and of boundary-layer transition control on the off-design performance characteristics are illustrated.
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- 1990
50. Parametric analysis of swept-wing geometry with sheared wing tips
- Author
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Fremaux, C. M, Vijgen, P. M. H. W, and Van Dam, C. P
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Aerodynamics - Abstract
A computational parameter study is presented of potential reductions in induced drag and increases in lateral-directional stability due to sheared wing tips attached to an untwisted wing of moderate sweep and aspect ratio. Sheared tips are swept and tapered wing-tip devices mounted in the plane of the wing. The induced-drag results are obtained using an inviscid, incompressible surface-panel method that models the nonlinear effects due to the deflected and rolled-up wake behind the lifting surface. The induced-drag results with planar sheared tips are compared to straight-tapered tip extensions and nonplanar winglet geometries. The lateral-directional static-stability characteristics of the wing with sheared tips are estimated using a quasi-vortex-lattice method. For certain combinations of sheared-tip sweep and taper, both the induced efficiency of the wing and the relevant static-stability derivatives are predicted to increase compared to the wing with a straight-tapered tip modification.
- Published
- 1990
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