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1. Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., Loonen, Jacqueline J., van der Pal, Helena J. H., de Vries, Andrica C. H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A. B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C. M., van Gorp, Marloes, and Grootenhuis, Martha A.

Published
2024
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3. A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors

Author

Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Published
2024
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5. Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors: A DCCSS LATER Study

Author

Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., and Kapusta, Livia

Published
2023
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8. Childhood cancer survivorship care during the COVID-19 pandemic: an international report of practice implications and provider concerns

Author

van den Oever, Selina R., Pluijm, Saskia M. F., Skinner, Rod, Glaser, Adam, Mulder, Renée L., Armenian, Saro, Bardi, Edit, Berger, Claire, Ehrhardt, Matthew J., Gilleland Marchak, Jordan, Haeusler, Gabrielle M., Hartogh, Jaap den, Hjorth, Lars, Kepak, Tomas, Kriviene, Izolda, Langer, Thorsten, Maeda, Miho, Márquez-Vega, Catalina, Michel, Gisela, Muraca, Monica, Najib, Mohamed, Nathan, Paul C., Panasiuk, Anna, Prasad, Maya, Roganovic, Jelena, Uyttebroeck, Anne, Winther, Jeanette F., Zadravec Zaletel, Lorna, van Dalen, Elvira C., van der Pal, Helena J. H., Hudson, Melissa M., and Kremer, Leontien C. M.

Published
2022
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10. Cardiac function in childhood cancer survivors treated with vincristine: Echocardiographic results from the DCCSS LATER 2 CARD study

Author

Merkx, Remy, Feijen, E. (Lieke) A.M., Leerink, Jan M., de Baat, Esmée C., Bellersen, Louise, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., de Korte, Chris L., Loonen, Jacqueline, Louwerens, Marloes, Ronckers, Cécile M., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Weijers, Gert, Kok, Wouter E.M., Kremer, Leontien C.M., and Kapusta, Livia

Published
2022
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13. Late hepatic toxicity surveillance for survivors of childhood, adolescent and young adult cancer: Recommendations from the international late effects of childhood cancer guideline harmonization group

Author

Bardi, Edit, Mulder, Renée L., van Dalen, Elvira C., Bhatt, Neel S., Ruble, Kathy A., Burgis, Jennifer, Castellino, Sharon M., Constine, Louis S., den Hoed, Caroline M., Green, Daniel M., Koot, Bart G.P., Levitt, Gill, Szonyi, László, Wallace, W. Hamish, Skinner, Roderick, Hudson, Melissa M., Kremer, Leontien C.M., Effinger, Karen E., and Bresters, Dorine

Published
2021
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14. Coronary artery disease surveillance among childhood, adolescent and young adult cancer survivors: A systematic review and recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van Dalen, Elvira C., Mulder, Renée L., Suh, Eugene, Ehrhardt, Matthew J., Aune, Gregory J., Bardi, Edit, Benson, Bradley J., Bergler-Klein, Jutta, Chen, Ming H., Frey, Eva, Hennewig, Ulrike, Lockwood, Liane, Martinsson, Ulla, Muraca, Monica, van der Pal, Helena, Plummer, Chris, Scheinemann, Katrin, Schindera, Christina, Tonorezos, Emily S., Wallace, W. Hamish, Constine, Louis S., Skinner, Roderick, Hudson, Melissa M., Kremer, Leontien C.M., Levitt, Gill, and Mulrooney, Daniel A.

Published
2021
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17. Cardiac Disease in Childhood Cancer Survivors: Risk Prediction, Prevention, and Surveillance: JACC CardioOncology State-of-the-Art Review

Author

Leerink, Jan M., de Baat, Esmée C., Feijen, Elizabeth A.M., Bellersen, Louise, van Dalen, Elvira C., Grotenhuis, Heynric B., Kapusta, Livia, Kok, Wouter E.M., Loonen, Jacqueline, van der Pal, Heleen J.H., Pluijm, Saskia M.F., Teske, Arco J., Mavinkurve-Groothuis, Annelies M.C., Merkx, Remy, and Kremer, Leontien C.M.

Published
2020
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18. Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors

Author

de Baat, Esmée C, primary, Merkx, Remy, additional, Leerink, Jan M, additional, Boerhout, Coen, additional, van der Pal, Heleen J H, additional, van Dalen, Elvira C, additional, Loonen, Jacqueline, additional, Bresters, Dorine, additional, van Dulmen-den Broeder, Eline, additional, van der Heiden-van der Loo, Margriet, additional, van den Heuvel, Marry M, additional, Kok, Judith L, additional, Louwerens, Marloes, additional, Neggers, Sebastian J C M M, additional, Ronckers, Cecline M, additional, Teepen, Jop C, additional, Tissing, Wim J E, additional, de Vries, Andrica C, additional, Kapusta, Livia, additional, Kremer, Leontien C M, additional, Mavinkurve-Groothuis, Annelies M C, additional, Kok, Wouter E M, additional, and Feijen, Elizabeth A M, additional

Published
2024
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20. Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study

Author

Leerink, Jan M., Feijen, E. Lieke A.M., van der Pal, Helena J.H., Kok, Wouter E.M., Mavinkurve-Groothuis, Annelies M.C., Kapusta, Livia, Pinto, Yigal M., Maas, Angela H.E.M., Bellersen, Louise, Teske, Arco J., Ronckers, Cécile M., Louwerens, Marloes, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Batenburg, Lilian, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline J., Neggers, Sebastian J.C.M.M., Versluys, A.B. Birgitta, Tissing, Wim J.E., and Kremer, Leontien C.M.

Published
2020
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21. A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Speerpunt, Zorg en O&O, Cancer, Child Health, Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Published
2024

22. Positive and negative survivor-specific psychosocial consequences of childhood cancer:the DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J.E., Loonen, Jacqueline J., van der Pal, Helena J.H., de Vries, Andrica C.H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A.B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C.M., van Gorp, Marloes, Grootenhuis, Martha A., Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J.E., Loonen, Jacqueline J., van der Pal, Helena J.H., de Vries, Andrica C.H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A.B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C.M., van Gorp, Marloes, and Grootenhuis, Martha A.

Abstract

Purpose: Numerous studies investigated generic psychosocial outcomes in survivors of childhood cancer (CCS). The present study aimed to describe survivor-specific psychosocial consequences in CCS, and to identify socio-demographic and medical associated factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed the Benefit & Burden Scale (BBSC) and the Impact of Cancer–Childhood Cancer (IOC-CS). Items were scored on a 5-point Likert scale (range 1–5). We examined outcomes with descriptive statistics, and socio-demographic and medical associated factors with regression analyses, corrected for multiple testing (p < 0.004). Results: CCS, N = 1713, age mean (M) 36 years, 49% female, ≥ 15 years since diagnosis, participated. On average, CCS reported ‘somewhat’ Benefit (M = 2.9), and ‘not at all’ to ‘a little’ Burden (M = 1.5) of childhood cancer. Average scores on IOC-CS’ positive impact scales ranged from 2.5 (Personal Growth) to 4.1 (Socializing), and on the negative impact scales from 1.4 (Financial Problems) to 2.4 (Thinking/Memory). Apart from cognitive problems, CCS reported challenges as worries about relationship status, fertility, and how cancer had affected siblings. Female sex was associated with more Personal Growth, and more negative impact. CCS more highly educated, partnered, and employed had higher positive and lower negative impact. CCS older at diagnosis reported more positive impact. CNS tumor survivors and those who had head/cranium radiotherapy had higher negative impact. CNS tumor survivors reported less positive impact. Conclusion and implications: The majority of CCS reported positive impact of cancer while most CCS reported little negative impact. While this may indicate resiliency in most CCS, health care providers should be aware that they can also experience survivor-specific challenges that warra

Published
2024

23. Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors

Author

De Baat, Esmée C., Merkx, Remy, Leerink, Jan M., Boerhout, Coen, Van Der Pal, Heleen J.H., Van Dalen, Elvira C., Loonen, Jacqueline, Bresters, Dorine, Van Dulmen-Den Broeder, Eline, Van Der Heiden-Van Der Loo, Margriet, Van Den Heuvel, Marry M., Kok, Judith L., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., Ronckers, Cecline M., Teepen, Jop C., Tissing, Wim J.E., De Vries, Andrica C., Kapusta, Livia, Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Feijen, Elizabeth A.M., De Baat, Esmée C., Merkx, Remy, Leerink, Jan M., Boerhout, Coen, Van Der Pal, Heleen J.H., Van Dalen, Elvira C., Loonen, Jacqueline, Bresters, Dorine, Van Dulmen-Den Broeder, Eline, Van Der Heiden-Van Der Loo, Margriet, Van Den Heuvel, Marry M., Kok, Judith L., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., Ronckers, Cecline M., Teepen, Jop C., Tissing, Wim J.E., De Vries, Andrica C., Kapusta, Livia, Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., and Feijen, Elizabeth A.M.

Abstract

Background: We assessed the prevalence and diagnostic value of ECG abnormalities for cardiomyopathy surveillance in childhood cancer survivors. Methods: In this cross-sectional study, 1381 survivors (≥5 years) from the Dutch Childhood Cancer Survivor Study part 2 and 272 siblings underwent a long-term follow-up ECG and echocardiography. We compared ECG abnormality prevalences using the Minnesota Code between survivors and siblings, and within biplane left ventricular ejection fraction (LVEF) categories. Among 880 survivors who received anthracycline, mitoxantrone or heart radiotherapy, logistic regression models using least absolute shrinkage and selection operator identified ECG abnormalities associated with three abnormal LVEF categories (<52% in male/<54% in female, <50% and <45%). We assessed the overall contribution of these ECG abnormalities to clinical regression models predicting abnormal LVEF, assuming an absence of systolic dysfunction with a <1% threshold probability. Results: 16% of survivors (52% female, mean age 34.7 years) and 14% of siblings had major ECG abnormalities. ECG abnormalities increased with decreasing LVEF. Integrating selected ECG data into the baseline model significantly improved prediction of sex-specific abnormal LVEF (c-statistic 0.66 vs 0.71), LVEF <50% (0.66 vs 0.76) and LVEF <45% (0.80 vs 0.86). While no survivor met the preset probability threshold in the first two models, the third model used five ECG variables to predict LVEF <45% and was applicable for ruling out (sensitivity 93%, specificity 56%, negative predictive value 99.6%). Calibration and internal validation tests performed well. Conclusion: A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell's criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%.

Published
2024

25. Recommendations for ototoxicity surveillance for childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCare Consortium

Author

Clemens, Eva, van den Heuvel-Eibrink, Marry M, Mulder, Renée L, Kremer, Leontien C M, Hudson, Melissa M, Skinner, Roderick, Constine, Louis S, Bass, Johnnie K, Kuehni, Claudia E, Langer, Thorsten, van Dalen, Elvira C, Bardi, Edith, Bonne, Nicolas-Xavier, Brock, Penelope R, Brooks, Beth, Carleton, Bruce, Caron, Eric, Chang, Kay W, Johnston, Karen, Knight, Kristin, Nathan, Paul C, Orgel, Etan, Prasad, Pinki K, Rottenberg, Jan, Scheinemann, Katrin, de Vries, Andrica C H, Walwyn, Thomas, Weiss, Annette, am Zehnhoff-Dinnesen, Antoinette, Cohn, Richard J, and Landier, Wendy

Published
2019
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27. Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors:A DCCSS LATER Study

Author

Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., Kapusta, Livia, Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., and Kapusta, Livia

Abstract

Background: Childhood cancer survivors (CCS) are at risk for cardiotoxicity. Objectives: We sought to assess how cardiac dysfunction measurements in CCS overlap and are differentially influenced by risk factors. Methods: This cross-sectional Dutch Childhood Cancer Survivor Study evaluated echocardiograms of 1,397 ≥5-year CCS and 277 siblings. Of CCS, n = 1,254 received cardiotoxic (anthracyclines/mitoxantrone/radiotherapy involving the heart region [RTheart]) and n = 143 received potentially cardiotoxic (cyclophosphamide, ifosfamide, or vincristine) therapy. We assessed demographic, treatment-related, and traditional cardiovascular risk factors for cardiac dysfunction using multivariable logistic regression. Results: CCS were a median of 26.7 years after diagnosis; 49% were women. Abnormal left ventricular ejection fraction (LVEF) (defined as <52% in men, <54% in women) occurred most commonly in CCS treated with anthracyclines and RTheart combined (38%). Age/sex-specific abnormal global longitudinal strain (GLS) occurred most commonly in CCS treated with RTheart, either with (41%) or without (38%) anthracyclines. Of CCS with normal LVEF, 20.2% showed abnormal GLS. Diastolic dysfunction grade ≥II was rare. Abnormal LVEF was mainly associated with female sex, anthracycline dose, and only in women, RTheart dose. Abnormal GLS was associated with female sex, RTheart dose, diastolic blood pressure, and only in women, anthracycline dose. Cyclophosphamide, ifosfamide, and vincristine were not associated with LVEF or GLS. Compared with siblings, CCS showed higher risk of abnormal LVEF (OR: 2.9; 95% CI: 1.4-6.6) and GLS (OR: 2.1; 95% CI: 1.2-3.7), independent of (potentially) cardiotoxic treatment-related and cardiovascular risk factors. Conclusions: Abnormal LVEF and GLS constitute complementary measures of systolic dysfunction among long-term CCS. Their diagnostic value may differ according to cardiotoxic expos

Published
2023

28. Acute and early-onset cardiotoxicity in children and adolescents with cancer: a systematic review

Author

Cardiologie patientenzorg, Child Health, Circulatory Health, Zorg en O&O, Cancer, Kouwenberg, Theodorus W, van Dalen, Elvira C, Feijen, Elizabeth A M, Netea, Stejara A, Bolier, Melissa, Slieker, Martijn G, Hoesein, Firdaus A A Mohamed, Kremer, Leontien C M, Grotenhuis, Heynric B, Mavinkurve-Groothuis, Annelies M C, Cardiologie patientenzorg, Child Health, Circulatory Health, Zorg en O&O, Cancer, Kouwenberg, Theodorus W, van Dalen, Elvira C, Feijen, Elizabeth A M, Netea, Stejara A, Bolier, Melissa, Slieker, Martijn G, Hoesein, Firdaus A A Mohamed, Kremer, Leontien C M, Grotenhuis, Heynric B, and Mavinkurve-Groothuis, Annelies M C

Published
2023

29. Safety of growth hormone replacement therapy in childhood-onset craniopharyngioma: a systematic review and cohort study

Author

Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, van Santen, H M, Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, and van Santen, H M

Published
2023

30. Thyroid dysfunction during treatment with systemic antineoplastic therapy for childhood cancer: a systematic review

Author

MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, van Dalen, Elvira C, MS Interne Geneeskunde, Endocrinologie onderzoek, CDL Cluster Speciële Diagnostiek, Other research (not in main researchprogram), PMC Medisch specialisten, Cluster C, Endocrinologie, Child Health, Speerpunt, Zorg en O&O, Cancer, Endocrinologie patientenzorg, Brain, van der Leij, Stephanie, Lebbink, Chantal A, Lentjes, Eef Gwm, Tissing, Wim Je, Stuart, Annemarie Verrijn, van den Heuvel-Eibrink, Marry M, van Santen, Hanneke M, and van Dalen, Elvira C

Published
2023

37. Systematic review and updated recommendations for cardiomyopathy surveillance for survivors of childhood, adolescent, and young adult cancer from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Ehrhardt, Matthew J, primary, Leerink, Jan M, additional, Mulder, Renée L, additional, Mavinkurve-Groothuis, Annelies, additional, Kok, Wouter, additional, Nohria, Anju, additional, Nathan, Paul C, additional, Merkx, Remy, additional, de Baat, Esmée, additional, Asogwa, Ogechukwu A, additional, Skinner, Roderick, additional, Wallace, Hamish, additional, Lieke Feijen, E A M, additional, de Ville de Goyet, Maëlle, additional, Prasad, Maya, additional, Bárdi, Edit, additional, Pavasovic, Vesna, additional, van der Pal, Helena, additional, Fresneau, Brice, additional, Demoor-Goldschmidt, Charlotte, additional, Hennewig, Ulrike, additional, Steinberger, Julia, additional, Plummer, Chris, additional, Chen, Ming Hui, additional, Teske, Arco J, additional, Haddy, Nadia, additional, van Dalen, Elvira C, additional, Constine, Louis S, additional, Chow, Eric J, additional, Levitt, Gill, additional, Hudson, Melissa M, additional, Kremer, Leontien C M, additional, and Armenian, Saro H, additional

Published
2023
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38. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

Armenian, Saro H, Hudson, Melissa M, Mulder, Renee L, Chen, Ming Hui, Constine, Louis S, Dwyer, Mary, Nathan, Paul C, Tissing, Wim J E, Shankar, Sadhna, Sieswerda, Elske, Skinner, Rod, Steinberger, Julia, van Dalen, Elvira C, van der Pal, Helena, Wallace, W Hamish, Levitt, Gill, and Kremer, Leontien C M

Published
2015
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39. Positive and negative survivor-specific psychosocial consequences of childhood cancer: the DCCSS-LATER 2 psycho-oncology study

Author

Maas, Anne, Maurice-Stam, Heleen, van der Aa-van Delden, Alied M., van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Tissing, Wim J.E., Loonen, Jacqueline J., van der Pal, Helena J.H., de Vries, Andrica C.H., van den Heuvel-Eibrink, Marry M., Janssens, Geert O., Ronckers, Cécile, Neggers, Sebastian, Bresters, Dorine, Louwerens, Marloes, Versluys, Birgitta A.B., van der Heiden-van der Loo, Margriet, Kremer, Leontien C.M., van Gorp, Marloes, Grootenhuis, Martha A., and Pediatrics

Subjects
SDG 3 - Good Health and Well-being
Abstract

Purpose: Numerous studies investigated generic psychosocial outcomes in survivors of childhood cancer (CCS). The present study aimed to describe survivor-specific psychosocial consequences in CCS, and to identify socio-demographic and medical associated factors. Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed 1963–2001) part 2 (age ≥ 18 years, diagnosed < 18 years, ≥ 5 years since diagnosis) completed the Benefit & Burden Scale (BBSC) and the Impact of Cancer–Childhood Cancer (IOC-CS). Items were scored on a 5-point Likert scale (range 1–5). We examined outcomes with descriptive statistics, and socio-demographic and medical associated factors with regression analyses, corrected for multiple testing (p < 0.004). Results: CCS, N = 1713, age mean (M) 36 years, 49% female, ≥ 15 years since diagnosis, participated. On average, CCS reported ‘somewhat’ Benefit (M = 2.9), and ‘not at all’ to ‘a little’ Burden (M = 1.5) of childhood cancer. Average scores on IOC-CS’ positive impact scales ranged from 2.5 (Personal Growth) to 4.1 (Socializing), and on the negative impact scales from 1.4 (Financial Problems) to 2.4 (Thinking/Memory). Apart from cognitive problems, CCS reported challenges as worries about relationship status, fertility, and how cancer had affected siblings. Female sex was associated with more Personal Growth, and more negative impact. CCS more highly educated, partnered, and employed had higher positive and lower negative impact. CCS older at diagnosis reported more positive impact. CNS tumor survivors and those who had head/cranium radiotherapy had higher negative impact. CNS tumor survivors reported less positive impact. Conclusion and implications: The majority of CCS reported positive impact of cancer while most CCS reported little negative impact. While this may indicate resiliency in most CCS, health care providers should be aware that they can also experience survivor-specific challenges that warrant monitoring/screening, information provision and psychosocial support.

Published
2023

40. Safety of Growth Hormone Replacement Therapy in Childhood-Onset Craniopharyngioma: A Systematic Review and Cohort Study

Author

van Schaik, Jiska, primary, Kormelink, Eline, additional, Kabak, Eda, additional, van Dalen, Elvira C, additional, Schouten-van Meeteren, Antoinette Y.N., additional, de Vos-Kerkhof, Evelien, additional, Bakker, Boudewijn, additional, Fiocco, Marta, additional, Hoving, Eelco W., additional, Tissing, Wim J.E., additional, and van Santen, Hanneke M., additional

Published
2023
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41. Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors: A PanCareSurFup and ProCardio Cohort and Nested Case-Control Study

Author

de Baat, Esmée C., primary, Feijen, Elizabeth A.M., additional, Reulen, Raoul C., additional, Allodji, Rodrigue S., additional, Bagnasco, Francesca, additional, Bardi, Edit, additional, Belle, Fabiën N., additional, Byrne, Julianne, additional, van Dalen, Elvira C., additional, Debiche, Ghazi, additional, Diallo, Ibrahima, additional, Grabow, Desiree, additional, Hjorth, Lars, additional, Jankovic, Momcilo, additional, Kuehni, Claudia E., additional, Levitt, Gill, additional, Llanas, Damien, additional, Loonen, Jacqueline, additional, Zaletel, Lorna Z., additional, Maule, Milena M., additional, Miligi, Lucia, additional, van der Pal, Helena J.H., additional, Ronckers, Cécile M., additional, Sacerdote, Carlotta, additional, Skinner, Roderick, additional, Jakab, Zsuzsanna, additional, Veres, Cristina, additional, Haddy, Nadia, additional, Winter, David L., additional, de Vathaire, Florent, additional, Hawkins, Michael M., additional, and Kremer, Leontien C.M., additional

Published
2023
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42. Primary cardioprotection with dexrazoxane in patients with childhood cancer who are expected to receive anthracyclines: recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

de Baat, Esmée C, primary, van Dalen, Elvira C, additional, Mulder, Renée L, additional, Hudson, Melissa M, additional, Ehrhardt, Matthew J, additional, Engels, Frederike K, additional, Feijen, Elizabeth A M, additional, Grotenhuis, Heynric B, additional, Leerink, Jan M, additional, Kapusta, Livia, additional, Kaspers, Gertjan J L, additional, Merkx, Remy, additional, Mertens, Luc, additional, Skinner, Roderick, additional, Tissing, Wim J E, additional, de Vathaire, Florent, additional, Nathan, Paul C, additional, Kremer, Leontien C M, additional, Mavinkurve-Groothuis, Annelies M C, additional, and Armenian, Saro, additional

Published
2022
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47. Candidate Plasma Biomarkers to Detect Anthracycline‐Related Cardiomyopathy in Childhood Cancer Survivors: A Case Control Study in the Dutch Childhood Cancer Survivor Study

Author

Leerink, Jan M., primary, Feijen, Elizabeth A. M., additional, Moerland, Perry D., additional, de Baat, Esmee C., additional, Merkx, Remy, additional, van der Pal, Helena J. H., additional, Tissing, Wim J. E., additional, Louwerens, Marloes, additional, van den Heuvel‐Eibrink, Marry M., additional, Versluys, A. Birgitta, additional, Asselbergs, Folkert W., additional, Sammani, Arjan, additional, Teske, Arco J., additional, van Dalen, Elvira C., additional, van der Heiden‐van der Loo, Margriet, additional, van Dulmen‐den Broeder, Eline, additional, de Vries, Andrica C. H., additional, Kapusta, Livia, additional, Loonen, Jacqueline, additional, Pinto, Yigal M., additional, Kremer, Leontien C. M., additional, Mavinkurve‐Groothuis, Annelies M. C., additional, and Kok, Wouter E. M., additional

Published
2022
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48. Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors:A Case Control Study in the Dutch Childhood Cancer Survivor Study

Author

Leerink, Jan M., Feijen, Elizabeth A.M., Moerland, Perry D., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, Asselbergs, Folkert W., Sammani, Arjan, Teske, Arco J., van Dalen, Elvira C., van der Heiden-Van der Loo, Margriet, van Dulmen-Den Broeder, Eline, de Vries, Andrica C.H., Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Leerink, Jan M., Feijen, Elizabeth A.M., Moerland, Perry D., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, Asselbergs, Folkert W., Sammani, Arjan, Teske, Arco J., van Dalen, Elvira C., van der Heiden-Van der Loo, Margriet, van Dulmen-Den Broeder, Eline, de Vries, Andrica C.H., Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Abstract

BACKGROUND: Plasma biomarkers may aid in the detection of anthracycline-related cardiomyopathy (ACMP). However, the cur-rently available biomarkers have limited diagnostic value in long-term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. METHODS AND RESULTS: We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction <45%, 29 anthracycline-treated controls with left ventricular ejection fraction ≥53% matched on sex, time after cancer, and anthracy-cline dose, and 29 patients with genetically determined dilated cardiomyopathy with left ventricular ejection fraction <45%. Multivariable linear regression was used to identify differentially expressed proteins. Elastic net model, including clinical char-acteristics, was used to assess discrimination of proteins diagnostic for ACMP. NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the inflammatory markers CCL19 (C-C motif chemokine ligands 19) and CCL20, PSPD (pulmonary surfactant protein-D), and PTN (pleiotrophin) were significantly upregulated in ACMP compared with controls. An elastic net model selected 45 proteins, including NT-proBNP, CCL19, CCL20 and PSPD, but not PTN, that discriminated ACMP cases from controls with an area under the receiver operating characteristic curve (AUC) of 0.78. This model was not superior to a model including NT-proBNP and clinical characteristics (AUC=0.75; P=0.766). However, when excluding 8 ACMP cases with heart failure, the full model was superior to that including only NT-proBNP and clinical characteristics (AUC=0.75 versus AUC=0.50; P=0.022). The same 45 proteins also showed good discrimination between dilated cardiomyopathy and controls (AUC=0.89), underscoring their association with cardiomyopathy. CONCLUSIONS: We identified 3 specific inflammatory proteins as candidate plasma biomarkers for ACMP in long-term childhood cancer survivors and demonstrated pro

Published
2022

49. Cardiac function in childhood cancer survivors treated with vincristine:Echocardiographic results from the DCCSS LATER 2 CARD study

Author

Merkx, Remy, Feijen, E. (Lieke) A.M., Leerink, Jan M., de Baat, Esmée C., Bellersen, Louise, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., de Korte, Chris L., Loonen, Jacqueline, Louwerens, Marloes, Ronckers, Cécile M., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Weijers, Gert, Kok, Wouter E.M., Kremer, Leontien C.M., Kapusta, Livia, Merkx, Remy, Feijen, E. (Lieke) A.M., Leerink, Jan M., de Baat, Esmée C., Bellersen, Louise, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., de Korte, Chris L., Loonen, Jacqueline, Louwerens, Marloes, Ronckers, Cécile M., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Weijers, Gert, Kok, Wouter E.M., Kremer, Leontien C.M., and Kapusta, Livia

Abstract

Background: Anthracyclines and radiotherapy involving the heart region are cardiotoxic, but the potential cardiotoxicity of vincristine remains unknown. We assessed cardiac function in vincristine-treated >5-year childhood cancer survivors (CCS). Methods and results: We cross-sectionally compared echocardiograms of 101 vincristine-treated CCS (median age 35 years [range: 17–53], median vincristine dose 63 mg/m2) from the national Dutch Childhood Cancer Survivor Study, LATER cohort, to 101 age- and sex-matched controls. CCS treated with anthracyclines, radiotherapy involving the heart region, cyclophosphamide or ifosfamide were excluded. Twelve CCS (14%) versus four controls (4%; p 0.034) had a decreased left ventricular ejection fraction (LVEF; men <52%, women <54%). Mean LVEF was 58.4% versus 59.7% (p 0.050). Global longitudinal strain (GLS) was abnormal in nineteen (24%) CCS versus eight controls (9%; p 0.011). Mean GLS was 19.0% versus 20.1% (p 0.001). No ≥grade 2 diastolic dysfunction was detected. In multivariable logistic regression analysis CCS had higher risk of abnormal GLS (OR 3.55, p 0.012), but not abnormal LVEF (OR 3.07, p 0.065), than controls. Blood pressure and smoking history contributed to variation in LVEF, whereas obesity and diastolic blood pressure contributed to variation in GLS. Cumulative vincristine dose was not associated with either abnormal LVEF or abnormal GLS in multivariable models corrected for age and sex (OR per 50 mg/m2: 0.88, p 0.85 and 1.14, p 0.82, respectively). Conclusions: Vincristine-treated long-term CCS showed an abnormal GLS more frequently than controls. Their risk for future clinical cardiac events and the role of risk factor modification should be further elucidated.

Published
2022

50. Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A Case Control Study in the Dutch Childhood Cancer Survivor Study

Author

PMC Medisch specialisten, Zorg en O&O, Child Health, Speerpunt, Haematologie patientenzorg, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Leerink, Jan M, Feijen, Elizabeth A M, Moerland, Perry D, de Baat, Esmee C, Merkx, Remy, van der Pal, Helena J H, Tissing, Wim J E, Louwerens, Marloes, van den Heuvel-Eibrink, Marry M, Versluys, A Birgitta, Asselbergs, Folkert W, Sammani, Arjan, Teske, Arco J, van Dalen, Elvira C, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M, Kremer, Leontien C M, Mavinkurve-Groothuis, Annelies M C, Kok, Wouter E M, PMC Medisch specialisten, Zorg en O&O, Child Health, Speerpunt, Haematologie patientenzorg, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Leerink, Jan M, Feijen, Elizabeth A M, Moerland, Perry D, de Baat, Esmee C, Merkx, Remy, van der Pal, Helena J H, Tissing, Wim J E, Louwerens, Marloes, van den Heuvel-Eibrink, Marry M, Versluys, A Birgitta, Asselbergs, Folkert W, Sammani, Arjan, Teske, Arco J, van Dalen, Elvira C, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M, Kremer, Leontien C M, Mavinkurve-Groothuis, Annelies M C, and Kok, Wouter E M

Published
2022

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