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30 results on '"van Berkel, Anouk"'

1. Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial

Author

DOCAO, Christine, Drui, Delphine, Borson Chazot, Francoise, Chabre, Olivier, Vezzosi, Delphine, Castinetti, Frederic, Bertherat, Jérôme, Libé, Rossella, Gimenez-Roqueplo, Anne Paule, Favier, Judith, Quinkler, Marcus, Strasburger, Christian, Zopf, Katrin, Reincke, Martin, Kroiss, Matthias, Remde, Hanna, Haaf, Michaela, Fuß, Carmina T, Dischinger, Ulrich, Eisenhofer, Graeme, Pamporaki, Christina, Van Berkel, Anouk, Baudin, Eric, Goichot, Bernard, Berruti, Alfredo, Hadoux, Julien, Moalla, Salma, Laboureau, Sandrine, Nölting, Svenja, de la Fouchardière, Christelle, Kienitz, Tina, Deutschbein, Timo, Zovato, Stefania, Amar, Laurence, Haissaguerre, Magalie, Timmers, Henri, Niccoli, Patricia, Faggiano, Antongiulio, Angokai, Moussa, Lamartina, Livia, Luca, Florina, Cosentini, Deborah, Hahner, Stefanie, Beuschlein, Felix, Attard, Marie, Texier, Matthieu, and Fassnacht, Martin

Published
2024
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4. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Papathomas, Thomas G, Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J, van Nederveen, Francien, Tischler, Arthur S, Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J, Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J, Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne-Paule, Dinjens, Winand NM, Korpershoek, Esther, and de Krijger, Ronald R

Published
2015
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6. [18F]FDG-PET/CT radiomics for the identification of genetic clusters in pheochromocytomas and paragangliomas.

Author

Noortman, Wyanne A., Vriens, Dennis, de Geus-Oei, Lioe-Fee, Slump, Cornelis H., Aarntzen, Erik H., van Berkel, Anouk, Timmers, Henri J. L. M., and van Velden, Floris H. P.

Abstract

Objectives: Based on germline and somatic mutation profiles, pheochromocytomas and paragangliomas (PPGLs) can be classified into different clusters. We investigated the use of [18F]FDG-PET/CT radiomics, SUVmax and biochemical profile for the identification of the genetic clusters of PPGLs.Methods: In this single-centre cohort, 40 PPGLs (13 cluster 1, 18 cluster 2, 9 sporadic) were delineated using a 41% adaptive threshold of SUVpeak ([18F]FDG-PET) and manually (low-dose CT; ldCT). Using PyRadiomics, 211 radiomic features were extracted. Stratified 5-fold cross-validation for the identification of the genetic cluster was performed using multinomial logistic regression with dimensionality reduction incorporated per fold. Classification performances of biochemistry, SUVmax and PET(/CT) radiomic models were compared and presented as mean (multiclass) test AUCs over the five folds. Results were validated using a sham experiment, randomly shuffling the outcome labels.Results: The model with biochemistry only could identify the genetic cluster (multiclass AUC 0.60). The three-factor PET model had the best classification performance (multiclass AUC 0.88). A simplified model with only SUVmax performed almost similarly. Addition of ldCT features and biochemistry decreased the classification performances. All sham AUCs were approximately 0.50.Conclusion: PET radiomics achieves a better identification of PPGLs compared to biochemistry, SUVmax, ldCT radiomics and combined approaches, especially for the differentiation of sporadic PPGLs. Nevertheless, a model with SUVmax alone might be preferred clinically, weighing model performances against laborious radiomic analysis. The limited added value of radiomics to the overall classification performance for PPGL should be validated in a larger external cohort.Key Points: • Radiomics derived from [18F]FDG-PET/CT has the potential to improve the identification of the genetic clusters of pheochromocytomas and paragangliomas. • A simplified model with SUVmax only might be preferred clinically, weighing model performances against the laborious radiomic analysis. • Cluster 1 and 2 PPGLs generally present distinctive characteristics that can be captured using [18F]FDG-PET imaging. Sporadic PPGLs appear more heterogeneous, frequently resembling cluster 2 PPGLs and occasionally resembling cluster 1 PPGLs. [ABSTRACT FROM AUTHOR]

Published
2022
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7. The Influence of the Exclusion of Central Necrosis on [18F]FDG PET Radiomic Analysis

Author

Noortman, Wyanne A., primary, Vriens, Dennis, additional, Mooij, Charlotte D. Y., additional, Slump, Cornelis H., additional, Aarntzen, Erik H., additional, van Berkel, Anouk, additional, Timmers, Henri J. L. M., additional, Bussink, Johan, additional, Meijer, Tineke W. H., additional, de Geus-Oei, Lioe-Fee, additional, and van Velden, Floris H. P., additional

Published
2021
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8. The influence of the exclusion of central necrosis on [18F]FDG PET radiomic analysis

Author

Noortman, Wyanne A. (author), Vriens, Dennis (author), Mooij, C.D.Y. (author), Slump, Cornelis H. (author), Aarntzen, Erik H. (author), van Berkel, Anouk (author), Timmers, Henri J.L.M. (author), Bussink, Johan (author), Meijer, Tineke W.H. (author), de Geus-Oei, Lioe Fee (author), van Velden, Floris H.P. (author), Noortman, Wyanne A. (author), Vriens, Dennis (author), Mooij, C.D.Y. (author), Slump, Cornelis H. (author), Aarntzen, Erik H. (author), van Berkel, Anouk (author), Timmers, Henri J.L.M. (author), Bussink, Johan (author), Meijer, Tineke W.H. (author), de Geus-Oei, Lioe Fee (author), and van Velden, Floris H.P. (author)

Abstract

Background: Central necrosis can be detected on [18F]FDG PET/CT as a region with little to no tracer uptake. Currently, there is no consensus regarding the inclusion of regions of central necrosis during volume of interest (VOI) delineation for radiomic analysis. The aim of this study was to assess how central necrosis affects radiomic analysis in PET. Methods: Forty-three patients, either with non-small cell lung carcinomas (NSCLC, n = 12) or with pheochromocytomas or paragangliomas (PPGL, n = 31), were included retrospectively. VOIs were delineated with and without central necrosis. From all VOIs, 105 radiomic features were extracted. Differences in radiomic features between delineation methods were assessed using a paired t-test with Benjamini-Hochberg multiple testing correction. In the PPGL cohort, performances of the radiomic models to predict the noradrenergic biochemical profile were assessed by comparing the areas under the receiver operating characteristic curve (AUC) for both delineation methods. Results: At least 65% of the features showed significant differences between VOIvital-tumour and VOIgross-tumour (65%, 79% and 82% for the NSCLC, PPGL and combined cohort, respectively). The AUCs of the radiomic models were not significantly different between delineation methods. Conclusion: In both tumour types, almost two-third of the features were affected, demonstrating that the impact of whether or not to include central necrosis in the VOI on the radiomic feature values is significant. Nevertheless, predictive performances of both delineation methods were comparable. We recommend that radiomic studies should report whether or not central necrosis was included during delineation., Biomechanical Engineering

Published
2021
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9. Impact of 123 I-MIBG scintigraphy on clinical decision making in pheochromocytoma and paraganglioma

Author

Rao, Dipti, van Berkel, Anouk, Piscaer, Ianthe, Young, William F, Gruber, Lucinda, Deutschbein, Timo, Fassnacht, Martin, Beuschlein, Felix, Spyroglou, Ariadni, Prejbisz, Aleksander, Hanus, Katarzyna, Eisenhofer, Graeme, Manelli, Massimo, Canu, Letizia, Lenders, Jacques W M, Bancos, Irina, Timmers, Henri J L M, University of Zurich, and van Berkel, Anouk

Subjects
2712 Endocrinology, Diabetes and Metabolism, 1303 Biochemistry, 10265 Clinic for Endocrinology and Diabetology, 610 Medicine & health, 1308 Clinical Biochemistry, 2704 Biochemistry (medical), 1310 Endocrinology
Published
2019

11. Impact of 123I-MIBG Scintigraphy on Clinical Decision-Making in Pheochromocytoma and Paraganglioma

Author

Rao, Dipti, primary, van Berkel, Anouk, additional, Piscaer, Ianthe, additional, Young, William F, additional, Gruber, Lucinda, additional, Deutschbein, Timo, additional, Fassnacht, Martin, additional, Beuschlein, Felix, additional, Spyroglou, Ariadni, additional, Prejbisz, Aleksander, additional, Hanus, Katarzyna, additional, Eisenhofer, Graeme, additional, Manelli, Massimo, additional, Canu, Letizia, additional, Lenders, Jacques W M, additional, Bancos, Irina, additional, and Timmers, Henri J L M, additional

Published
2019
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12. Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers

Author

Rijken, Johannes, primary, van Hulsteijn, Leonie, additional, Dekkers, Olaf, additional, Niemeijer, Nicolasine, additional, Leemans, C., additional, Eijkelenkamp, Karin, additional, van der Horst-Schrivers, Anouk, additional, Kerstens, Michiel, additional, van Berkel, Anouk, additional, Timmers, Henri, additional, Kunst, Henricus, additional, Bisschop, Peter, additional, Dreijerink, Koen, additional, van Dooren, Marieke, additional, Hes, Frederik, additional, Jansen, Jeroen, additional, Corssmit, Eleonora, additional, and Hensen, Erik, additional

Published
2019
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14. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, and Zmuda, Erik

Published
2017

15. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, and Zmuda, Erik

Published
2017

16. The phenotype of SDHB germline mutation carriers: a nationwide study

Author

Niemeijer, Nicolasine D, primary, Rijken, Johannes A, additional, Eijkelenkamp, Karin, additional, van der Horst-Schrivers, Anouk N A, additional, Kerstens, Michiel N, additional, Tops, Carli M J, additional, van Berkel, Anouk, additional, Timmers, Henri J L M, additional, Kunst, Henricus P M, additional, Leemans, C René, additional, Bisschop, Peter H, additional, Dreijerink, Koen M A, additional, van Dooren, Marieke F, additional, Bayley, Jean-Pierre, additional, Pereira, Alberto M, additional, Jansen, Jeroen C, additional, Hes, Frederik J, additional, Hensen, Erik F, additional, and Corssmit, Eleonora P M, additional

Published
2017
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17. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Fishbein, Lauren, primary, Leshchiner, Ignaty, additional, Walter, Vonn, additional, Danilova, Ludmila, additional, Robertson, A. Gordon, additional, Johnson, Amy R., additional, Lichtenberg, Tara M., additional, Murray, Bradley A., additional, Ghayee, Hans K., additional, Else, Tobias, additional, Ling, Shiyun, additional, Jefferys, Stuart R., additional, de Cubas, Aguirre A., additional, Wenz, Brandon, additional, Korpershoek, Esther, additional, Amelio, Antonio L., additional, Makowski, Liza, additional, Rathmell, W. Kimryn, additional, Gimenez-Roqueplo, Anne-Paule, additional, Giordano, Thomas J., additional, Asa, Sylvia L., additional, Tischler, Arthur S., additional, Pacak, Karel, additional, Nathanson, Katherine L., additional, Wilkerson, Matthew D., additional, Akbani, Rehan, additional, Ally, Adrian, additional, Amar, Laurence, additional, Arachchi, Harindra, additional, Auchus, Richard J., additional, Auman, J. Todd, additional, Baertsch, Robert, additional, Balasundaram, Miruna, additional, Balu, Saianand, additional, Bartsch, Detlef K., additional, Baudin, Eric, additional, Bauer, Thomas, additional, Beaver, Allison, additional, Benz, Christopher, additional, Beroukhim, Rameen, additional, Beuschlein, Felix, additional, Bodenheimer, Tom, additional, Boice, Lori, additional, Bowen, Jay, additional, Bowlby, Reanne, additional, Brooks, Denise, additional, Carlsen, Rebecca, additional, Carter, Suzie, additional, Cassol, Clarissa A., additional, Cherniack, Andrew D., additional, Chin, Lynda, additional, Cho, Juok, additional, Chuah, Eric, additional, Chudamani, Sudha, additional, Cope, Leslie, additional, Crain, Daniel, additional, Curley, Erin, additional, de Krijger, Ronald R., additional, Demchok, John A., additional, Deutschbein, Timo, additional, Dhalla, Noreen, additional, Dimmock, David, additional, Dinjens, Winand N.M., additional, Eng, Charis, additional, Eschbacher, Jennifer, additional, Fassnacht, Martin, additional, Felau, Ina, additional, Feldman, Michael, additional, Ferguson, Martin L., additional, Fiddes, Ian, additional, Fishbein, Lauren, additional, Frazer, Scott, additional, Gabriel, Stacey B., additional, Gardner, Johanna, additional, Gastier-Foster, Julie M., additional, Gehlenborg, Nils, additional, Gerken, Mark, additional, Getz, Gad, additional, Geurts, Jennifer, additional, Goldman, Mary, additional, Graim, Kiley, additional, Gupta, Manaswi, additional, Haan, David, additional, Hahner, Stefanie, additional, Hantel, Constanze, additional, Haussler, David, additional, Hayes, D. Neil, additional, Heiman, David I., additional, Hoadley, Katherine A., additional, Holt, Robert A., additional, Hoyle, Alan P., additional, Huang, Mei, additional, Hunt, Bryan, additional, Hutter, Carolyn M., additional, Jones, Steven J.M., additional, Jones, Corbin D., additional, Kasaian, Katayoon, additional, Kebebew, Electron, additional, Kim, Jaegil, additional, Kimes, Patrick, additional, Knijnenburg, Theo, additional, Lander, Eric, additional, Lawrence, Michael S., additional, Lechan, Ronald, additional, Lee, Darlene, additional, Leraas, Kristen M., additional, Lerario, Antonio, additional, Lin, Pei, additional, Liu, Jia, additional, LiVolsi, Virginia A., additional, Lolla, Laxmi, additional, Lotan, Yair, additional, Lu, Yiling, additional, Ma, Yussanne, additional, Maison, Nicole, additional, Mallery, David, additional, Mannelli, Massimo, additional, Marquard, Jessica, additional, Marra, Marco A., additional, Matthew, Thomas, additional, Mayo, Michael, additional, Méatchi, Tchao, additional, Meng, Shaowu, additional, Merino, Maria J., additional, Mete, Ozgur, additional, Meyerson, Matthew, additional, Mieczkowski, Piotr A., additional, Mills, Gordon B., additional, Moore, Richard A., additional, Morozova, Olena, additional, Morris, Scott, additional, Mose, Lisle E., additional, Mungall, Andrew J., additional, Naresh, Rashi, additional, Newton, Yulia, additional, Ng, Sam, additional, Ni, Ying, additional, Noble, Michael S., additional, Nwariaku, Fiemu, additional, Parker, Joel S., additional, Paul, Evan, additional, Penny, Robert, additional, Perou, Charles M., additional, Perou, Amy H., additional, Pihl, Todd, additional, Powers, James, additional, Rabaglia, Jennifer, additional, Radenbaugh, Amie, additional, Ramirez, Nilsa C., additional, Rao, Arjun, additional, Riester, Anna, additional, Roach, Jeffrey, additional, Sadeghi, Sara, additional, Saksena, Gordon, additional, Salama, Sofie, additional, Saller, Charles, additional, Sandusky, George, additional, Sbiera, Silviu, additional, Schein, Jacqueline E., additional, Schumacher, Steven E., additional, Shelton, Candace, additional, Shelton, Troy, additional, Sheth, Margi, additional, Shi, Yan, additional, Shih, Juliann, additional, Shmulevich, Ilya, additional, Simons, Janae V., additional, Sipahimalani, Payal, additional, Skelly, Tara, additional, Sofia, Heidi J., additional, Sokolov, Artem, additional, Soloway, Matthew G., additional, Sougnez, Carrie, additional, Stuart, Josh, additional, Sun, Charlie, additional, Swatloski, Teresa, additional, Tam, Angela, additional, Tan, Donghui, additional, Tarnuzzer, Roy, additional, Tarvin, Katherine, additional, Thiessen, Nina, additional, Thorne, Leigh B., additional, Timmers, Henri J., additional, Tse, Kane, additional, Uzunangelov, Vlado, additional, van Berkel, Anouk, additional, Veluvolu, Umadevi, additional, Vicha, Ales, additional, Voet, Doug, additional, Waldmann, Jens, additional, Wan, Yunhu, additional, Wang, Zhining, additional, Wang, Tracy S., additional, Weaver, Joellen, additional, Weinstein, John N., additional, Weismann, Dirk, additional, Wise, Lisa, additional, Wong, Tina, additional, Wong, Christopher, additional, Wu, Ye, additional, Yang, Liming, additional, Zelinka, Tomas, additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Zhang, Wei, additional, Zhu, Jingchun, additional, Zinzindohoué, Franck, additional, and Zmuda, Erik, additional

Published
2017
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18. Eruption of Metastatic Paraganglioma After Successful Therapy with 177Lu/90Y-DOTATOC and 177Lu-DOTATATE.

Author

Wolf, Katherine I., Jha, Abhishek, van Berkel, Anouk, Wild, Damian, Janssen, Ingo, Millo, Corina M., Janssen, M. J. R., Gonzales, Melissa K., Timmers, Henri J. K. M., and Pacak, Karel

Abstract

Metastatic paraganglioma treatment options are limited. Peptide receptor radionuclide therapy (PRRT) has been introduced as a novel management option for metastatic neuroendocrine tumors demonstrating safety, efficacy, and increased quality of life. We present two cases of marked progression of metastatic paraganglioma following initial partial response to PRRT. Given their positivity on 68Ga-DOTATATE PET/CT and 111In-octreotide SPECT, they underwent PRRT. Imaging following treatment revealed significant improvement in size and intensity, with some foci nearly completely resolved in one patient, and disease regression with a decrease in the number and size of bone and liver lesions in the second patient. Within months, repeat imaging in both patients revealed extensive metastatic disease with new lesions, which eventually lead to their deaths. The mechanism for rapid disease progression after partial response is not well understood, although it could be related to initially high Ki-67 levels or 18F-FDG PET/CT SUVmax values. However, naturally rapid disease progression despite PRRT response cannot be excluded. This finding warrants the importance of proper patient counseling along with early and accurate pre-PRRT assessment, taking into consideration the above potential risk factors for therapy response in order to personalize treatment regimens and achieve maximum patient benefit. ClinicalTrials.gov Identifier: NCT00004847 [ABSTRACT FROM AUTHOR]

Published
2019
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20. Sunitinib for metastatic progressive phaeochromocytomas and paragangliomas: results from FIRSTMAPPP, an academic, multicentre, international, randomised, placebo-controlled, double-blind, phase 2 trial

Author

Baudin, Eric, Goichot, Bernard, Berruti, Alfredo, Hadoux, Julien, Moalla, Salma, Laboureau, Sandrine, Nölting, Svenja, de la Fouchardière, Christelle, Kienitz, Tina, Deutschbein, Timo, Zovato, Stefania, Amar, Laurence, Haissaguerre, Magalie, Timmers, Henri, Niccoli, Patricia, Faggiano, Antongiulio, Angokai, Moussa, Lamartina, Livia, Luca, Florina, Cosentini, Deborah, Hahner, Stefanie, Beuschlein, Felix, Attard, Marie, Texier, Matthieu, Fassnacht, Martin, DOCAO, Christine, Drui, Delphine, Borson Chazot, Francoise, Chabre, Olivier, Vezzosi, Delphine, Castinetti, Frederic, Bertherat, Jérôme, Libé, Rossella, Gimenez-Roqueplo, Anne Paule, Favier, Judith, Quinkler, Marcus, Strasburger, Christian, Zopf, Katrin, Reincke, Martin, Kroiss, Matthias, Remde, Hanna, Haaf, Michaela, Fuß, Carmina T, Dischinger, Ulrich, Eisenhofer, Graeme, Pamporaki, Christina, and Van Berkel, Anouk

Abstract

No randomised controlled trial has ever been done in patients with metastatic phaeochromocytomas and paragangliomas. Preclinical and first clinical evidence suggested beneficial effects of sunitinib. We aimed to evaluate the safety and efficacy of sunitinib in patients with metastatic phaeochromocytomas and paragangliomas.

Published
2024
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21. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas : A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, De Krijger, Ronald R., Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, and De Krijger, Ronald R.

Published
2015

22. SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: A multicenter interobserver variation analysis using virtual microscopy: A Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)

Author

Pathologie patiënten zorg, Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, De Krijger, Ronald R., Pathologie patiënten zorg, Papathomas, Thomas G., Oudijk, Lindsey, Persu, Alexandre, Gill, Anthony J., Van Nederveen, Francien, Tischler, Arthur S., Tissier, Frédérique, Volante, Marco, Matias-Guiu, Xavier, Smid, Marcel, Favier, Judith, Rapizzi, Elena, Libe, Rosella, Currás-Freixes, Maria, Aydin, Selda, Huynh, Thanh, Lichtenauer, Urs, Van Berkel, Anouk, Canu, Letizia, Domingues, Rita, Clifton-Bligh, Roderick J., Bialas, Magdalena, Vikkula, Miikka, Baretton, Gustavo, Papotti, Mauro, Nesi, Gabriella, Badoual, Cécile, Pacak, Karel, Eisenhofer, Graeme, Timmers, Henri J., Beuschlein, Felix, Bertherat, Jérôme, Mannelli, Massimo, Robledo, Mercedes, Gimenez-Roqueplo, Anne Paule, Dinjens, Winand N M, Korpershoek, Esther, and De Krijger, Ronald R.

Published
2015

23. Prognosis of Malignant Pheochromocytoma and Paraganglioma (MAPP-Prono Study): A European Network for the Study of Adrenal Tumors Retrospective Study.

Author

Hescot, Segolene, Curras-Freixes, Maria, Deutschbein, Timo, van Berkel, Anouk, Vezzosi, Delphine, Amar, Laurence, de la Fouchardière, Christelle, Valdes, Nuria, Riccardi, Fernando, Do Cao, Christine, Bertherat, Jerome, Goichot, Bernard, Beuschlein, Felix, Drui, Delphine, Canu, Letizia, Niccoli, Patricia, Laboureau, Sandrine, Tabarin, Antoine, Leboulleux, Sophie, Calsina, Bruna, Libé, Rossella, Faggiano, Antongiulio, Schlumberger, Martin, Borson-Chazot, Francoise, Mannelli, Massimo, Gimenez-Roqueplo, Anne-Paule, Caron, Philippe, Timmers, Henri J L M, Fassnacht, Martin, Robledo, Mercedes, Borget, Isabelle, and Baudin, Eric

Abstract

Malignant pheochromocytoma and paraganglioma (MPP) are characterized by prognostic heterogeneity. Our objective was to look for prognostic parameters of overall survival (OS) in MPP patients.

Published
2019
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24. Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters

Author

van Berkel, Anouk, primary, Rao, Jyotsna U., additional, Lenders, Jacques W.M., additional, Pellegata, Natalia S., additional, Kusters, Benno, additional, Piscaer, Ianthe, additional, Hermus, Ad R.M.M., additional, Plantinga, Theo S., additional, Langenhuijsen, Johan F., additional, Vriens, Dennis, additional, Janssen, Marcel J.R., additional, Gotthardt, Martin, additional, and Timmers, Henri J.L.M., additional

Published
2015
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25. Correlation Between In Vivo 18F-FDG PET and Immunohistochemical Markers of Glucose Uptake and Metabolism in Pheochromocytoma and Paraganglioma

Author

van Berkel, Anouk, primary, Rao, Jyotsna U., additional, Kusters, Benno, additional, Demir, Tuna, additional, Visser, Eric, additional, Mensenkamp, Arjen R., additional, van der Laak, Jeroen A.W.M., additional, Oosterwijk, Egbert, additional, Lenders, Jacques W.M, additional, Sweep, Fred C.G.J., additional, Wevers, Ron A., additional, Hermus, Ad R., additional, Langenhuijsen, Johan F., additional, Kunst, Dirk P.M., additional, Pacak, Karel, additional, Gotthardt, Martin, additional, and Timmers, Henri J.L.M., additional

Published
2014
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26. Semiquantitative 123I-Metaiodobenzylguanidine Scintigraphy to Distinguish Pheochromocytoma and Paraganglioma from Physiologic Adrenal Uptake and Its Correlation with Genotype-Dependent Expression of Catecholamine Transporters.

Author

van Berkel, Anouk, Rao, Jyotsna U., Lenders, Jacques W. M., Pellegata, Natalia S., Kusters, Benno, Piscaer, Ianthe, Hermus, Ad R. M. M., Plantinga, Theo S., Langenhuijsen, Johan F., Vriens, Dennis, Janssen, Marcel J. R., Gotthardt, Martin, and Timmers, Henri J. L. M.

Published
2015
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27. The Influence of the Exclusion of Central Necrosis on [ 18 F]FDG PET Radiomic Analysis.

Author

Noortman, Wyanne A., Vriens, Dennis, Mooij, Charlotte D. Y., Slump, Cornelis H., Aarntzen, Erik H., van Berkel, Anouk, Timmers, Henri J. L. M., Bussink, Johan, Meijer, Tineke W. H., de Geus-Oei, Lioe-Fee, and van Velden, Floris H. P.

Subjects
RECEIVER operating characteristic curves, NECROSIS
Abstract

Background: Central necrosis can be detected on [18F]FDG PET/CT as a region with little to no tracer uptake. Currently, there is no consensus regarding the inclusion of regions of central necrosis during volume of interest (VOI) delineation for radiomic analysis. The aim of this study was to assess how central necrosis affects radiomic analysis in PET. Methods: Forty-three patients, either with non-small cell lung carcinomas (NSCLC, n = 12) or with pheochromocytomas or paragangliomas (PPGL, n = 31), were included retrospectively. VOIs were delineated with and without central necrosis. From all VOIs, 105 radiomic features were extracted. Differences in radiomic features between delineation methods were assessed using a paired t-test with Benjamini–Hochberg multiple testing correction. In the PPGL cohort, performances of the radiomic models to predict the noradrenergic biochemical profile were assessed by comparing the areas under the receiver operating characteristic curve (AUC) for both delineation methods. Results: At least 65% of the features showed significant differences between VOIvital-tumour and VOIgross-tumour (65%, 79% and 82% for the NSCLC, PPGL and combined cohort, respectively). The AUCs of the radiomic models were not significantly different between delineation methods. Conclusion: In both tumour types, almost two-third of the features were affected, demonstrating that the impact of whether or not to include central necrosis in the VOI on the radiomic feature values is significant. Nevertheless, predictive performances of both delineation methods were comparable. We recommend that radiomic studies should report whether or not central necrosis was included during delineation. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Metabolic Subtyping of Pheochromocytoma and Paraganglioma by 18 F-FDG Pharmacokinetics Using Dynamic PET/CT Scanning.

Author

van Berkel A, Vriens D, Visser EP, Janssen MJR, Gotthardt M, Hermus ARMM, Geus-Oei LF, and Timmers HJLM

Subjects
Adrenal Gland Neoplasms diagnostic imaging, Adrenal Gland Neoplasms metabolism, Adult, Aged, Aged, 80 and over, Biological Transport, Female, Fluorodeoxyglucose F18 metabolism, Humans, Male, Middle Aged, Young Adult, Fluorodeoxyglucose F18 pharmacokinetics, Paraganglioma diagnostic imaging, Paraganglioma metabolism, Pheochromocytoma diagnostic imaging, Pheochromocytoma metabolism, Positron Emission Tomography Computed Tomography
Abstract

Static single-time-frame 18 F-FDG PET/CT is useful for the localization and functional characterization of pheochromocytomas and paragangliomas (PPGLs). 18 F-FDG uptake varies between PPGLs with different genotypes, and the highest SUVs are observed in cases of succinate dehydrogenase ( SDH ) mutations, possibly related to enhanced aerobic glycolysis in tumor cells. The exact determinants of 18 F-FDG accumulation in PPGLs are unknown. We performed dynamic PET/CT scanning to assess whether in vivo 18 F-FDG pharmacokinetics has added value over static PET to distinguish different genotypes. Methods: Dynamic 18 F-FDG PET/CT was performed on 13 sporadic PPGLs and 13 PPGLs from 11 patients with mutations in SDH complex subunits B and D, von Hippel-Lindau ( VHL ), RET, and neurofibromin 1 ( NF1 ). Pharmacokinetic analysis was performed using a 2-tissue-compartment tracer kinetic model. The derived transfer rate-constants for transmembranous glucose flux ( K 1 [in], k 2 [out]) and intracellular phosphorylation ( k 3 ), along with the vascular blood fraction (V b ), were analyzed using nonlinear regression analysis. Glucose metabolic rate (MR glc ) was calculated using Patlak linear regression analysis. The SUV max of the lesions was determined on additional static PET/CT images. Results: Both MR glc and SUV max were significantly higher for hereditary cluster 1 ( SDHx, VHL ) tumors than for hereditary cluster 2 ( RET, NF1 ) and sporadic tumors ( P < 0.01 and P < 0.05, respectively). Median k 3 was significantly higher for cluster 1 than for sporadic tumors ( P < 0.01). Median V b was significantly higher for cluster 1 than for cluster 2 tumors ( P < 0.01). No statistically significant differences in K 1 and k 2 were found between the groups. Cutoffs for k 3 to distinguish between cluster 1 and other tumors were established at 0.015 min -1 (100% sensitivity, 15.8% specificity) and 0.636 min -1 (100% specificity, 85.7% sensitivity). MR glc significantly correlated with SUV max ( P = 0.001) and k 3 ( P = 0.002). Conclusion: In vivo metabolic tumor profiling in patients with PPGL can be achieved by assessing 18 F-FDG pharmacokinetics using dynamic PET/CT scanning. Cluster 1 PPGLs can be reliably identified by a high 18 F-FDG phosphorylation rate., (© 2019 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2019
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29. [Sexual dysfunction as a side effect of medication].

Author

van Berkel A, Seldenrijk A, Knegtering H, Bakker PR, Ruhé HG, and Kramers C

Subjects
Female, Humans, Male, Drug-Related Side Effects and Adverse Reactions, Sexual Dysfunction, Physiological chemically induced, Sexual Dysfunctions, Psychological chemically induced
Published
2018

30. [A refugee with inguinal lymfadenopathy and skin lesions].

Author

van Berkel A, van Lümig PPM, and Elving LD

Subjects
Adult, Biopsy methods, Diagnosis, Differential, Groin, Humans, Male, Refugees, Lymph Nodes pathology, Lymphadenopathy diagnosis, Pruritus diagnosis, Scabies diagnosis, Skin pathology
Abstract

We present a 30-years-old man with lymphadenopathy and itchy skin lesions. One lymphoblast and atypical lymphocytes were found in the peripheral blood. Histopathologic examination of a skin punch biopsy revealed scabies. Lymphadenopathy is normally only seen in patients with widespread long-lasting scabies crustosa. However, this case illustrates that scabies should also be included in the differential diagnosis of patients with lymphadenopathy and only a few itchy skin lesions.

Published
2018

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