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1. Risk and determinants of low and very low bone mineral density and fractures in a national cohort of Dutch adult childhood cancer survivors (DCCSS-LATER): a cross-sectional study

Author

van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J, Pluijm, Saskia M F, Kremer, Leontien C M, Ronckers, Cécile M, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Olsson, Daniel S, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Tissing, Wim J E, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M

Published
2023
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2. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors: evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van Atteveld, Jenneke E, Mulder, Renée L, van den Heuvel-Eibrink, Marry M, Hudson, Melissa M, Kremer, Leontien C M, Skinner, Roderick, Wallace, W Hamish, Constine, Louis S, Higham, Claire E, Kaste, Sue C, Niinimäki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J, Ward, Leanne M, Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E, Amin, Nadia L, Vrooman, Lynda M, Harila-Saari, Arja, Demoor-Goldschmidt, Charlotte, Murray, Robert D, Bardi, Edit, Lequin, Maarten H, Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K, Neggers, Sebastian J C M M, Pluijm, Saskia M F, Simmons, Jill H, and Di Iorgi, Natascia

Published
2021
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4. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER): a cross-sectional study

Author

van Atteveld, Jenneke E, primary, de Winter, Demi T C, additional, Pluimakers, Vincent G, additional, Fiocco, Marta, additional, Nievelstein, Rutger A J, additional, Hobbelink, Monique G G, additional, Kremer, Leontien C M, additional, Grootenhuis, Martha A, additional, Maurice-Stam, Heleen, additional, Tissing, Wim J E, additional, de Vries, Andrica C H, additional, Loonen, Jacqueline J, additional, van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J H, additional, Pluijm, Saskia M F, additional, van der Heiden-van der Loo, Margriet, additional, Versluijs, A Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M, additional, Hoefer, Imo, additional, van den Berg, Sjoerd A A, additional, den Hartogh, Jaap, additional, Hoeijmakers, Jan H J, additional, Neggers, Sebastian J C M M, additional, and van den Heuvel-Eibrink, Marry M, additional

Published
2023
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5. Frailty and sarcopenia within the earliest national Dutch childhood cancer survivor cohort (DCCSS-LATER):a cross-sectional study

Author

van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, van den Heuvel-Eibrink, Marry M, van Atteveld, Jenneke E, de Winter, Demi T C, Pluimakers, Vincent G, Fiocco, Marta, Nievelstein, Rutger A J, Hobbelink, Monique G G, Kremer, Leontien C M, Grootenhuis, Martha A, Maurice-Stam, Heleen, Tissing, Wim J E, de Vries, Andrica C H, Loonen, Jacqueline J, van Dulmen-den Broeder, Eline, van der Pal, Helena J H, Pluijm, Saskia M F, van der Heiden-van der Loo, Margriet, Versluijs, A Birgitta, Louwerens, Marloes, Bresters, Dorine, van Santen, Hanneke M, Hoefer, Imo, van den Berg, Sjoerd A A, den Hartogh, Jaap, Hoeijmakers, Jan H J, Neggers, Sebastian J C M M, and van den Heuvel-Eibrink, Marry M

Abstract

BACKGROUND: Childhood cancer survivors appear to be at increased risk of frailty and sarcopenia, but evidence on the occurrence of and high-risk groups for these aging phenotypes is scarce, especially in European survivors. The aim of this cross-sectional study was to assess the prevalence of and explore risk factors for pre-frailty, frailty, and sarcopenia in a national cohort of Dutch childhood cancer survivors diagnosed between 1963 and 2001.METHODS: Eligible individuals (alive at the time of study, living in the Netherlands, age 18-45 years, and had not previously declined to participate in a late-effects study) from the Dutch Childhood Cancer Survivor Study (DCCSS-LATER) cohort were invited to take part in this cross-sectional study. We defined pre-frailty and frailty according to modified Fried criteria, and sarcopenia according to the European Working Group on Sarcopenia in Older People 2 definition. Associations between these conditions and demographic and treatment-related as well as endocrine and lifestyle-related factors were estimated with two separate multivariable logistic regression models in survivors with any frailty measurement or complete sarcopenia measurements.FINDINGS: 3996 adult survivors of the DCCSS-LATER cohort were invited to participate in this cross-sectional study. 1993 non-participants were excluded due to lack of response or a decline to participate and 2003 (50·1%) childhood cancer survivors aged 18-45 years were included. 1114 (55·6%) participants had complete frailty measurements and 1472 (73·5%) participants had complete sarcopenia measurements. Mean age at participation was 33·1 years (SD 7·2). 1037 (51·8%) participants were male, 966 (48·2%) were female, and none were transgender. In survivors with complete frailty measurements or complete sarcopenia measurements, the percentage of pre-frailty was 20·3% (95% CI 18·0-22·7), frailty was 7·4% (6·0-9·0), and sarcopenia was 4·4% (3·5-5·6). In the models for pre-frai

Published
2023

6. Prevalence, risk factors, and optimal way to determine overweight, obesity, and morbid obesity in the first Dutch cohort of 2338 long-term survivors of childhood cancer: a DCCSS-LATER study.

Author

Pluimakers, Vincent G., van Atteveld, Jenneke E., de Winter, Demi T. C., Bolier, Melissa, Fiocco, Marta, Nievelstein, Rutger Jan A. J., Janssens, Geert O. R., Bresters, Dorine, van der Heiden-van der Loo, Margriet, de Vries, Andrica C. H., Louwerens, Marloes, van der Pal, Heleen J., Pluijm, Saskia M. F., Ronckers, Cecile M., Versluijs, Andrica B., Kremer, Leontien C. M., Loonen, Jacqueline J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., and van Santen, Hanneke M.

Subjects
*DISEASE risk factors, *OVERWEIGHT persons, *OBESITY, *CHILDHOOD cancer, *CANCER survivors
Abstract

Background: Overweight and obesity are common challenges among childhood cancer survivors. Overweight may be disguised, as survivors can have normal weight but high fat percentage (fat%) on dual-energy X-ray absorptiometry (DXA). We aimed to assess prevalence, identify determinants and biomarkers, and assess which method captures overweight best, in a nationwide cohort. Methods: The prevalence of overweight and obesity, primarily defined by body mass index (BMI), was assessed in the DCCSS-LATER cohort of adult survivors treated from 1963-2002, with the LifeLines cohort as reference. The associations between risk factors and overweight metrics were investigated using logistic regression. Additional overweight metrics included DXA fat%, waist circumference (WC), waist/hip ratio (WHR), waist/height ratio (WHtR), and high-molecular-weight (HMW) adiponectin. Results: A total of 2338 (mean age 35.5 years, follow-up 28.3 years) survivors participated. The overweight prevalence was 46.3% in men and 44.3% in women (obesity 11.2% and 15.9%, morbid obesity 2.4% and 5.4%), with highest rates among brain tumor survivors. Compared to controls, there was no overall increased overweight rate, but this was higher in women > 50 years, morbid obesity in men > 50 years. Overweight at cancer diagnosis (adjusted odds ratio [aOR] = 3.83, 95% CI 2.19-6.69), cranial radiotherapy (aOR = 3.21, 95% CI 1.99-5.18), and growth hormone deficiency (separate model, aOR = 1.61, 95% CI 1.00-2.59) were associated with overweight. Using BMI, WC, WHR, and WHtR, overweight prevalence was similar. Low HMW adiponectin, present in only 4.5% of survivors, was an insensitive overweight marker. Dual-energy X-ray absorptiometry–based classification identified overweight in an additional 30%, particularly after abdominal radiotherapy, total body irradiation, anthracyclines, and platinum. Conclusions: Overweight occurs in almost half of long-term survivors. There was no overall increased incidence of overweight compared to controls. We identified factors associated with overweight, as well as subgroups of survivors in whom DXA can more reliably assess overweight. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Frailty and Sarcopenia within the Earliest Dutch Childhood Cancer Survivor Cohort (n=2,003): A Dccss-Later Study

Author

van Atteveld, Jenneke E., primary, de Winter, Demi T.C., additional, Pluimakers, Vincent G., additional, Fiocco, Marta, additional, Nievelstein, Rutger A.J., additional, Hobbelink, Monique G.G., additional, Kremer, Leontien C.M., additional, Ronckers, Cécile M., additional, Grootenhuis, Martha A., additional, Maurice-Stam, Heleen, additional, Tissing, Wim J.E., additional, de Vries, Andrica C.H., additional, Loonen, Jacqueline J., additional, Van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J., additional, Pluijm, Saskia, additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M., additional, Hoefer, Imo, additional, van den Berg, Sjoerd A.A., additional, Hoeijmakers, Jan H.J., additional, Neggers, Sebastian J.C.M.M., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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8. Modifiable Risk Factors Are Associated with Reduced Bone Mineral Density and Fractures in a National Cohort of 2,003 Dutch Childhood Cancer Survivors

Author

de Winter, Demi T.C., primary, Van Atteveld, Jenneke E., additional, Pluimakers, Vincent G., additional, Fiocco, Marta, additional, Nievelstein, Rutger A.J., additional, Hobbelink, Monique G.G., additional, de Vries, Andrica C.H., additional, Loonen, Jacqueline J., additional, Van Dulmen-den Broeder, Eline, additional, van der Pal, Helena J., additional, Pluijm, Saskia M.F., additional, Kremer, Leontien C.M., additional, Ronckers, Cécile M., additional, van der Heiden-van der Loo, Margriet, additional, Versluys, Birgitta, additional, Louwerens, Marloes, additional, Bresters, Dorine, additional, van Santen, Hanneke M., additional, Olsson, Daniel S., additional, Hoefer, Imo, additional, van den Berg, Sjoerd A.A., additional, den Hartogh, Jaap, additional, Tissing, Wim J.E., additional, Neggers, Sebastian J.C.M.M., additional, and van den Heuvel-Eibrink, Marry M., additional

Published
2022
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10. Overweight in the Dutch National Cohort of Long-Term Survivors of Childhood Cancer

Author

Pluimakers, Vincent G., primary, Van Atteveld, Jenneke E., additional, de Winter, Demi T.C., additional, Fiocco, Marta, additional, Nievelstein, Rutger A.J., additional, Bresters, Dorine, additional, Van der Heiden-Van der Loo, Margriet, additional, de Vries, Andrica, additional, Janssens, Geert O, additional, Louwerens, Marloes, additional, Van der Pal, Helena J., additional, Ronckers, Cecile M., additional, Van Santen, Hanneke M., additional, Versluys, Birgitta, additional, Kremer, Leontien, additional, Loonen, Jacqueline J., additional, Tissing, Wim J.E., additional, Van Dulmen-Den Broeder, Eline, additional, van den Heuvel-Eibrink, Marry M., additional, and Neggers, Sebastian J.C.M.M., additional

Published
2021
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11. A Validated Risk Prediction Model for Bone Fragility in Children with Acute Lymphoblastic Leukemia

Author

Verwaaijen, Emma Jacobine, primary, Ma, Jinhui, additional, De Groot-Kruseman, Hester A., additional, Pieters, Rob, additional, Van Der Sluis, Inge M., additional, Van Atteveld, Jenneke E., additional, Halton, Jacqueline, additional, Fernandez, Conrad, additional, Hartman, Annelies, additional, de Jonge, Robert, additional, Lequin, Maarten, additional, te Winkel, Mariël L., additional, Atkinson, Stephanie A., additional, Alos, Nathalie, additional, Barr, Ronald, additional, Grant, Ronald M., additional, Hay, John, additional, Huber, Adam, additional, Ho, Josephine, additional, Jaremko, Jacob, additional, Koujok, Khaldoun, additional, Lang, Bianca, additional, Matzinger, Mary-Ann, additional, Shenouda, Nazih, additional, Rauch, Frank, additional, Rodd, Celia, additional, van den Heuvel-Eibrink, Marry M., additional, Pluijm, Saskia M.F., additional, and Ward, Leanne, additional

Published
2021
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13. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors : evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja H., Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., Di Iorgi, Natascia, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja H., Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., and Di Iorgi, Natascia

Abstract

Childhood, adolescent, and young adult cancer survivors are at increased risk of reduced bone mineral density. Clinical practice surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could improve bone mineral density parameters and prevent fragility fractures. Discordances across current late effects guidelines necessitated international harmonisation of recommendations for bone mineral density surveillance. The International Late Effects of Childhood Cancer Guideline Harmonization Group therefore established a panel of 36 experts from ten countries, representing a range of relevant medical specialties. The evidence of risk factors for very low and low bone mineral density and fractures, surveillance modality, timing of bone mineral density surveillance, and treatment of very low and low bone mineral density were evaluated and critically appraised, and harmonised recommendations for childhood, adolescent, and young adult cancer survivors were formulated. We graded the recommendations based on the quality of evidence and balance between potential benefits and harms. Bone mineral density surveillance is recommended for survivors treated with cranial or craniospinal radiotherapy and is reasonable for survivors treated with total body irradiation. Due to insufficient evidence, no recommendation can be formulated for or against bone mineral density surveillance for survivors treated with corticosteroids. This surveillance decision should be made by the survivor and health-care provider together, after careful consideration of the potential harms and benefits and additional risk factors. We recommend to carry out bone mineral density surveillance using dualenergy x-ray absorptiometry at entry into long-term follow-up, and if normal (Z-score > -1), repeat when the survivor is aged 25 years. Between these measurements and thereafter, surveillance should be done as clinically indicated. These recommendations facilitate evidenc

Published
2021
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14. Recent perspectives on the association between osteonecrosis and bone mineral density decline in childhood acute lymphoblasticleukemia

Author

van Atteveld, Jenneke E, de Winter, Demi TC, Pieters, Rob, Neggers, Sebastian JCMM, van den Heuvel-Eibrink, Marry M, van Atteveld, Jenneke E, de Winter, Demi TC, Pieters, Rob, Neggers, Sebastian JCMM, and van den Heuvel-Eibrink, Marry M

Abstract

The attention to treatment related toxicity has increased since the survival of children with acute lymphoblastic leukemia (ALL) has improved significantly over the past few decades. Intensive ALL treatment schedules including corticosteroids and asparaginase have been shown to give rise to skeletal abnormalities such as osteonecrosis and low bone mineral density (BMD), which may lead to debilitating sequelae in survivors. Although osteonecrosis and low BMD are different entities with suggested separate pathophysiological mechanisms, recent studies indicate that osteonecrosis is associated with accelerated BMD decline. Common underlying mechanisms for osteonecrosis and BMD decline are considered, such as an enhanced sensitivity to corticosteroids in children who suffer from both osteonecrosis and low BMD. In addition, restriction of weight-bearing activities, which is generally advised in patients with osteonecrosis, could aggravate BMD decline. This induces a clinical dilemma, since bone stimulation is important to maintain BMD but alternative interventions for osteonecrosis are limited. Furthermore, this recent finding of accelerated BMD decline in children with osteonecrosis emphasizes the need to develop effective preventive measures for osteonecrosis, which may include targeting BMD decline.

Published
2021

15. Overweight in the Dutch National Cohort of Long-Term Survivors of Childhood Cancer

Author

Child Health, Arts-assistenten Radiologie, SCT patientenzorg, MS Radiotherapie, Zorg en O&O, Endocrinologie patientenzorg, Brain, Cancer, Speerpunt, Pluimakers, Vincent, Van Atteveld, Jenneke E., de Winter, Demi T.C., Fiocco, M., Nievelstein, Rutger Jan, Bresters, Dorine, van der Heiden-van der Loo, Margriet, de Vries, Andrica C, Janssens, Geert O, Louwerens, Marloes, van der Pal, Helena J H, Ronckers, Cécile, van Santen, HM, Versluijs, Birgitta, Kremer, Leontien, Loonen, Jacqueline J, Tissing, Wim, Van Dulmen-Den Broeder, Eline, van den Heuvel-Eibrink, M.M., Neggers, Sebastian J C M M, Child Health, Arts-assistenten Radiologie, SCT patientenzorg, MS Radiotherapie, Zorg en O&O, Endocrinologie patientenzorg, Brain, Cancer, Speerpunt, Pluimakers, Vincent, Van Atteveld, Jenneke E., de Winter, Demi T.C., Fiocco, M., Nievelstein, Rutger Jan, Bresters, Dorine, van der Heiden-van der Loo, Margriet, de Vries, Andrica C, Janssens, Geert O, Louwerens, Marloes, van der Pal, Helena J H, Ronckers, Cécile, van Santen, HM, Versluijs, Birgitta, Kremer, Leontien, Loonen, Jacqueline J, Tissing, Wim, Van Dulmen-Den Broeder, Eline, van den Heuvel-Eibrink, M.M., and Neggers, Sebastian J C M M

Published
2021

16. Bone mineral density surveillance for childhood, adolescent, and young adult cancer survivors: evidence-based recommendations from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Author

MS Radiologie, Circulatory Health, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja, Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., Di Iorgi, Natascia, MS Radiologie, Circulatory Health, van Atteveld, Jenneke E., Mulder, Renee L., van den Heuvel-Eibrink, Marry M., Hudson, Melissa M., Kremer, Leontien C. M., Skinner, Roderick, Wallace, W. Hamish, Constine, Louis S., Higham, Claire E., Kaste, Sue C., Niinimaki, Riitta, Mostoufi-Moab, Sogol, Alos, Nathalie, Fintini, Danilo, Templeton, Kimberly J., Ward, Leanne M., Frey, Eva, Franceschi, Roberto, Pavasovic, Vesna, Karol, Seth E., Amin, Nadia L., Vrooman, Lynda M., Harila-Saari, Arja, Demoor-Goldschmidt, Charlotte, Murray, Robert D., Bardi, Edit, Lequin, Maarten H., Faienza, Maria Felicia, Zaikova, Olga, Berger, Claire, Mora, Stefano, Ness, Kirsten K., Neggers, Sebastian J. C. M. M., Pluijm, Saskia M. F., Simmons, Jill H., and Di Iorgi, Natascia

Published
2021

17. Vitamin D supplementation for children with cancer: A systematic review and consensus recommendations

Author

Speerpunt, Zorg en O&O, Child Health, Endocrinologie patientenzorg, Brain, Cancer, van Atteveld, Jenneke E., Verhagen, Iris E., van den Heuvel-Eibrink, Marry M., van Santen, Hanneke M., van der Sluis, Inge M., Di Iorgi, Natascia, Simmons, Jill H., Ward, Leanne M., Neggers, Sebastian J.C.M.M., Speerpunt, Zorg en O&O, Child Health, Endocrinologie patientenzorg, Brain, Cancer, van Atteveld, Jenneke E., Verhagen, Iris E., van den Heuvel-Eibrink, Marry M., van Santen, Hanneke M., van der Sluis, Inge M., Di Iorgi, Natascia, Simmons, Jill H., Ward, Leanne M., and Neggers, Sebastian J.C.M.M.

Published
2021

18. Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols

Author

PMC Research, van Atteveld, Jenneke E, de Groot-Kruseman, Hester A, Fiocco, Marta, Lequin, Maarten H, Neggers, Sebastian J C M M, Pluijm, Saskia M F, van der Sluis, Inge M, Pieters, Rob, van den Heuvel-Eibrink, Marry M, PMC Research, van Atteveld, Jenneke E, de Groot-Kruseman, Hester A, Fiocco, Marta, Lequin, Maarten H, Neggers, Sebastian J C M M, Pluijm, Saskia M F, van der Sluis, Inge M, Pieters, Rob, and van den Heuvel-Eibrink, Marry M

Published
2021

20. A Validated Risk Prediction Model for Bone Fragility in Children With Acute Lymphoblastic Leukemia.

Author

Verwaaijen, Emma J., Ma, Jinhui, de Groot‐Kruseman, Hester A., Pieters, Rob, van der Sluis, Inge M., van Atteveld, Jenneke E., Halton, Jacqueline, Fernandez, Conrad V., Hartman, Annelies, de Jonge, Robert, Lequin, Maarten H., te Winkel, Mariël L., Alos, Nathalie, Atkinson, Stephanie A., Barr, Ronald, Grant, Ronald M., Hay, John, Huber, Adam M., Ho, Josephine, and Jaremko, Jacob

Abstract

Although bone fragility may already be present at diagnosis of pediatric acute lymphoblastic leukemia (ALL), routine performance of dual‐energy X‐ray absorptiometry (DXA) in every child is not universally feasible. The aim of this study was to develop and validate a risk prediction model for low lumbar spine bone mineral density (LS BMD Z‐score ≤ −2.0) at diagnosis, as an important indicator for fracture risk and further treatment‐related BMD aggravation. Children with ALL (4–18 years), treated according to the Dutch Childhood Oncology Group protocol (DCOG‐ALL9; model development; n = 249) and children from the Canadian Steroid‐Associated Osteoporosis in the Pediatric Population cohort (STOPP; validation; n = 99) were included in this study. Multivariable logistic regression analyses were used to develop the prediction model and to confirm the association of low LS BMD at diagnosis with symptomatic fractures during and shortly after cessation of ALL treatment. The area under the receiver operating characteristic curve (AUC) was used to assess model performance. The prediction model for low LS BMD at diagnosis using weight (β = −0.70) and age (β = −0.10) at diagnosis revealed an AUC of 0.71 (95% CI, 0.63–0.78) in DCOG‐ALL9 and 0.74 (95% CI, 0.63–0.84) in STOPP, and resulted in correct identification of 71% of the patients with low LS BMD. We confirmed that low LS BMD at diagnosis is associated with LS BMD at treatment cessation (OR 5.9; 95% CI, 3.2–10.9) and with symptomatic fractures (OR 1.7; 95% CI, 1.3–2.4) that occurred between diagnosis and 12 months following treatment cessation. In meta‐analysis, LS BMD at diagnosis (OR 1.6; 95% CI, 1.1–2.4) and the 6‐month cumulative glucocorticoid dose (OR 1.9; 95% CI, 1.1–3.2) were associated with fractures that occurred in the first year of treatment. In summary, a prediction model for identifying pediatric ALL patients with low LS BMD at diagnosis, as an important indicator for bone fragility, was successfully developed and validated. This can facilitate identification of future bone fragility in individual pediatric ALL patients. © 2021 American Society for Bone and Mineral Research (ASBMR). [ABSTRACT FROM AUTHOR]

Published
2021
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21. Prediction of Low and Very Low Bone Mineral Density Among Adult Survivors of Childhood Cancer

Author

van Atteveld, Jenneke E., primary, Pluijm, Saskia M.F., additional, Ness, Kirsten K., additional, Hudson, Melissa M., additional, Chemaitilly, Wassim, additional, Kaste, Sue C., additional, Robison, Leslie L., additional, Neggers, Sebastian J.C.M.M., additional, Yasui, Yutaka, additional, van den Heuvel-Eibrink, Marry M., additional, and Wilson, Carmen L., additional

Published
2019
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23. Very Long-term Sequelae after Nonradical Surgery Combined with Brachytherapy in an Infant with a Chemotherapy-resistant Rhabdomyosarcoma of the Tongue

Author

PMC Medisch specialisten, Zorg en O&O, MS Radiologie, Circulatory Health, Van Rijswijk, Petra M., Van Den Heuvel-Eibrink, Marry M., van den Akker, Erica L. T., Slagter, Cleo, Lequin, Maarten H., Aarsen, Femke K., Van Atteveld, Jenneke E., Wagner, Anja, Van Grotel, Martine, PMC Medisch specialisten, Zorg en O&O, MS Radiologie, Circulatory Health, Van Rijswijk, Petra M., Van Den Heuvel-Eibrink, Marry M., van den Akker, Erica L. T., Slagter, Cleo, Lequin, Maarten H., Aarsen, Femke K., Van Atteveld, Jenneke E., Wagner, Anja, and Van Grotel, Martine

Published
2017

26. The Predictive Value of Vitamin D Serum Concentration for Osteopenia and Fractures in Children with Hematological Malignancies

Author

Van Atteveld, Jenneke E., Verhagen, Iris E., Pieters, Rob, Van Den Heuvel-Eibrink, M.M. Van Den, and Pluijm, Saskia M.F.

Abstract

Background-Impaired bone mineral density (BMD) is a frequently reported side-effect of patients with childhood cancer. Vitamin D deficiency is suggested to be a risk factor for diminished BMD and fractures during and after cessation of treatment of childhood hematological malignancies.

Published
2017
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27. Influence of bisphosphonates or recombinant human parathyroid hormone on in vitro sensitivity of acute lymphoblastic leukemia cells to chemotherapy.

Author

De Winter DTC, Van Atteveld JE, Buijs-Gladiness JGCAM, Pieters R, Neggers SJCMM, Meijerink JPP, and Van den Heuvel-Eibrink MM

Subjects
Humans, Parathyroid Hormone pharmacology, Diphosphonates pharmacology, Diphosphonates therapeutic use, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Published
2023
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28. Vitamin D supplementation for children with cancer: A systematic review and consensus recommendations.

Author

van Atteveld JE, Verhagen IE, van den Heuvel-Eibrink MM, van Santen HM, van der Sluis IM, Di Iorgi N, Simmons JH, Ward LM, and Neggers SJCMM

Subjects
Adolescent, Calcium, Dietary administration & dosage, Cancer Survivors, Child, Child, Preschool, Consensus, Fractures, Bone blood, Fractures, Bone etiology, Humans, Observational Studies as Topic, Precursor Cell Lymphoblastic Leukemia-Lymphoma blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy, Randomized Controlled Trials as Topic, Vitamin D administration & dosage, Vitamin D blood, Vitamin D Deficiency complications, Bone Density, Fractures, Bone prevention & control, Hematologic Neoplasms blood, Hematologic Neoplasms complications, Hematologic Neoplasms therapy, Neoplasms blood, Neoplasms complications, Neoplasms therapy, Vitamin D analogs & derivatives, Vitamin D Deficiency therapy, Vitamins administration & dosage
Abstract

Background: Prevalent vitamin D deficiency (VDD) and low bone mineral density (BMD) have led to vitamin D supplementation for children with cancer, regardless vitamin D status. However, it remains unsettled whether this enhances bone strength. We sought to address this issue by carrying out a systematic review of the literature., Methods: We conducted a literature search using PubMed, Embase, and Cochrane databases. Studies including children up to 5 years after cancer therapy were assessed for the association between 25-hydroxyvitamin D (25OHD) levels and BMD Z-scores or fractures, and the effect of vitamin D supplementation on BMD or fractures. Evidence quality was assessed using the GRADE methodology., Results: Nineteen studies (16 observational and 3 interventional, mainly involving children with hematologic malignancies) were included. One study which analyzed 25OHD as a threshold variable (≤10 ng/ml) found a significant association between 25OHD levels and BMD Z-scores, while 25OHD as a continuous variable was not significantly associated with BMD Z-scores in 14 observational studies. We found neither a significant association between lower 25OHD levels and fractures (2 studies), nor between vitamin D (and calcium) supplementation and BMD or fracture frequency (3 studies) (very low quality evidence)., Conclusion: There is a lack of evidence for an effect of vitamin D (and calcium) supplementation on BMD or fractures in children with cancer. Further research is needed; until then, we recommend dietary vitamin D/calcium intake in keeping with standard national guidelines, and periodic 25OHD monitoring to detect levels <20 ng/ml. Vitamin D/calcium supplementation is recommended in children with low levels, to maintain levels ≥20 ng/ml year-long., (© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)

Published
2021
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29. Effect of post-consolidation regimen on symptomatic osteonecrosis in three DCOG acute lymphoblastic leukemia protocols.

Author

van Atteveld JE, de Groot-Kruseman HA, Fiocco M, Lequin MH, Neggers SJCMM, Pluijm SMF, van der Sluis IM, Pieters R, and van den Heuvel-Eibrink MM

Subjects
Antineoplastic Combined Chemotherapy Protocols adverse effects, Dexamethasone therapeutic use, Humans, Osteonecrosis chemically induced, Osteonecrosis drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Published
2021
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