Search

Your search keyword '"van Alphen, Loek"' showing total 285 results
Start Over Author "van Alphen, Loek"
285 results on '"van Alphen, Loek"'

8. Pneumococcal conjugate vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains

Author

Van Gils, Elske J.M., Veenhoven, Reinier H., Hak, Eelko, Rodenburg, Gerwin D., Keijzers, Wendy C.M., Bogaert, Debby, Trzeinski, Krzysztof, Bruin, Jacob P., van Alphen, Loek, van der Ende Arie, and Sanders, Elisabeth A.M.

Subjects
Pneumococcal infections -- Drug therapy, Pneumococcal infections -- Control, Pneumococcal vaccine -- Health aspects, Pneumococcal vaccine -- Dosage and administration, Vaccination -- Health aspects
Abstract

The study attempts to evaluate the relationship and association between PCV-7 vaccination and nasopharyngeal acquisition of pneumococcal serotype 19A strains. The results indicate that PCV-7 was associated with an increase in the same as compared with unvaccinated controls.

Published
2010

38. Spectrum of invasive Haemophilus influenzae type b disease in adults

Author

Takala, Aino K., Eskola, Juhani, and van Alphen, Loek

Subjects
Hemophilus influenzae -- Demographic aspects, Hemophilus infections -- Risk factors, Health
Abstract

Infections caused by Haemophilus influenzae type b bacteria are a significant cause of illness and death among young children. The infection can cause meningitis and can lead to epiglottitis, swelling and closure of the airway. Vaccines now provide effective protection for children against the disease. Adults are usually protected against this infection by antibodies which recognize the bacteria. However, this immunity may decline with age or due to disease, such as cancer, lung disease, or alcoholism. To better identify adults at risk for H. influenzae type b disease, the characteristics of the 31 adults in Finland who contracted the infection over a 3.5-year period were evaluated. Thirteen patients had septicemia (systemic bacterial infection), seven had pneumonia, six had epiglottitis, three developed meningitis, and two had arthritis. The overall mortality was 26 percent, with five deaths occurring among those with septicemia, two among those with pneumonia, and one in a patient with epiglottitis. Seventeen patients were male, and the average age was 53 years, but all patients with epiglottitis were female, and all but two were under 36 years old. Except for patients with epiglottitis, most had predisposing conditions such as alcoholism, cancer, lung disease, diabetes, rheumatoid arthritis, recent surgery, pregnancy, or AIDS. These disorders are associated with defective immunity and were more prevalent among those who developed septicemia or pneumonia. The young women with epiglottitis likely represent those to whom bacteria were transmitted by their children. The results suggest that adults with these severe diseases would benefit most from vaccination against H. influenzae type b, and would be most likely to benefit from vaccination with influenza and pneumococcal vaccines. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

47. Lipoprotein signal peptidase of Streptococcus suis serotype 2

Author

de Greeff, Astrid, Hamilton, Andrea, Sutcliffe, Lain C., Buys, Herma, van Alphen, Loek, and Smith, Hilde E.

Subjects
Bacterial proteins -- Physiological aspects, Cellular signal transduction -- Physiological aspects, Lipoproteins -- Genetic aspects, Lipoproteins -- Physiological aspects, Proteolipids, Streptococcus -- Research, Biological sciences
Abstract

Research describes expression and coding sequence of the lipoprotein signal peptidase, Lsp, from Streptococcus suis. Expression of Lsp in Escherichia coli enhances globomycin resistance. In the absence of Lsp coding gene, S. suis processes lipoproteins incorrectly. Furthermore, both wild-type and the mutant strains of S. suis are equally virulent.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results