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The present study introduces the concept of validating data quality indicators through re-classification. We use the term re-classification to mean the evaluation of how well an indicator detects the quality of different versions of a survey question for which the quality is known a priori. We illustrate its application with two examples. In both, we make use of 12 questions from prior experiments that manipulated text features of questions to create 'low' and 'high' quality versions of each question. In the first example, we coded each question version in SQP 2.1 to obtain indicators of validity, reliability, and quality. We compared these indicators between the two versions of each question to assess whether the SQP outcomes were sensitive to text features. In the second example, we used a pretest survey to obtain three indicators of survey quality: response latencies, item nonresponse, and consistency over time. Again, we compared these indicators between question versions to assess whether the indicators were sensitive to text features. We give recommendations for applying re-classification and an outlook for future research opportunities. [ABSTRACT FROM AUTHOR]

This study explores the development and validation of an airflow model to support climate prediction for Citrus Under Protective Screens (CUPS) in California. CUPS is a permeable screen structure designed to protect a field of citrus trees from large insects including the vector that causes the devastating citrus greening disease. Because screen structures modify the environmental conditions (e.g., temperature, relative humidity, airflow), farm management and treatment strategies (e.g., pesticide spraying events) must be modified to account for these differences. Toward this end, we develop a model for predicting wind speed and direction in a commercial-scale research CUPS, using a computational fluid dynamics (CFD) model. We describe the model and validate it in two ways. In the first, we model a small-scale replica CUPS under controlled conditions and compare modeled and measured airflow in and around the replica structure. In the second, we model the full-scale CUPS and use historical measurements to back test the models accuracy. In both settings, the modeled airflow values fall within statistical confidence intervals generated from the corresponding measurements of the conditions being modeled. These findings suggest that the model can aid decision support and smart agriculture solutions for farmers as they adapt their farm management practices for CUPS structures.

OBJECTIVE: To determine the reliability and agreement of manual and automated morphological measurements, and agreement in morphological diagnoses. METHODS: Thirty pelvic radiographs were randomly selected from the World COACH consortium. Manual and automated measurements of acetabular depth-width ratio (ADR), modified acetabular index (mAI), alpha angle (AA), Wiberg center edge angle (WCEA), lateral center edge angle (LCEA), extrusion index (EI), neck-shaft angle (NSA), and triangular index ratio (TIR) were performed. Bland-Altman plots and intraclass correlation coefficients (ICCs) were used to test reliability. Agreement in diagnosing acetabular dysplasia, pincer and cam morphology by manual and automated measurements was assessed using percentage agreement. Visualizations of all measurements were scored by a radiologist. RESULTS: The Bland-Altman plots showed no to small mean differences between automated and manual measurements for all measurements except for ADR. Intraobserver ICCs of manual measurements ranged from 0.26 (95%-CI 0-0.57) for TIR to 0.95 (95%-CI 0.87-0.98) for LCEA. Interobserver ICCs of manual measurements ranged from 0.43 (95%-CI 0.10-0.68) for AA to 0.95 (95%-CI 0.86-0.98) for LCEA. Intermethod ICCs ranged from 0.46 (95%-CI 0.12-0.70) for AA to 0.89 (95%-CI 0.78-0.94) for LCEA. Radiographic diagnostic agreement ranged from 47% to 100% for the manual observers and 63%-96% for the automated method as assessed by the radiologist. CONCLUSION: The automated algorithm performed equally well compared to manual measurement by trained observers, attesting to its reliability and efficiency in rapidly computing morphological measurements. This validated method can aid clinical practice and accelerate hip osteoarthritis research.

Purpose: The purpose of this research was to develop and assess the psychometric properties of the Persian version of the Life Skills Scale for Physical Education (P-LSSPE). Method: During Study 1, which included four translators, eight physical education experts, and 45 physical education students, the LSSPE was translated and adapted into Persian, and its content validity was assessed. Study 2 assessed evidence for the factorial validity and reliability of the scale with a sample of 1,004 students. Study 3, which included 462 students, assessed nomological validity evidence. Results: In Study 1, the content validity analyses indicated that the P-LSSPE items and their dimensions were clear in language, practical in application, and represented the life skills in question. In Study 2, a bifactor confirmatory factor analysis model was the best representation of the data and provided evidence for the construct validity of the scale. In Study 3, evidence for the nomological validity of the P-LSSPE was provided, with the correlation coefficients indicating that teacher autonomy support was associated with students' development of all eight life skills and total life skills. Discussion/Conclusion: Overall, the findings of this research suggest that the P-LSSPE can be used to accurately measure the life skills development of Iranian physical education students. [ABSTRACT FROM AUTHOR]

The adoption of simulation models as Digital Twins (DTs) has been standing out in recent years and represents a revolution in decision-making. In this context, we note increasingly faster and more efficient decisions by mirroring the behaviour of physical systems. On the other hand, we highlight the challenges to ensure the simulation models validity over time since traditional validation approaches have limitations when we consider the periodic update of the model. Thus, the present work proposes an approach based on the constant assessment of these models through Machine Learning and control charts. To this end, we suggest a monitoring tool using the K-Nearest Neighbors (K-NN) classifier, combined with a p-control chart, to periodically assess the validity of DT simulation models. The proposed approach was tested in several theoretical cases and also implemented in a real case study. The findings suggest that the proposed tool can monitor the DT functioning and identify possible special causes that could compromise its results. Finally, we highlight the wide applicability of the proposed tool, which can be used in different DT models, including near/real-time models with different characteristics regarding connection, integration, and complexity. [ABSTRACT FROM AUTHOR]

In the initial stage of their federally funded research project, the authors detail how they developed and validated a set of assessment tools aimed at measuring undergraduate students' academic engagement and their own definition of academic success. To ensure the tools were measuring what they were intended to, and that they were reliable, the authors enlisted content experts, including a librarian with academic engagement expertise, three educational psychologists with specialization in college students' engagement, self-regulation, and related fields, and two psychometricians with knowledge of psychological measurement. The authors also reflect on the lessons they learned from the process of developing and validating the assessment tools. [ABSTRACT FROM AUTHOR]

In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, model building and refinement, validation, and archiving of such structures. This report describes the workshop's motivation and history, the topics discussed, and the resulting consensus recommendations. Some challenges for future methods-development efforts in this area are also highlighted, as is the implementation to date of some of the recommendations.

Comparative analysis of (meta)genomes necessitates aggregation, integration, and synthesis of well-annotated data using standards. The Genomic Standards Consortium (GSC) collaborates with the research community to develop and maintain the Minimum Information about any (x) Sequence (MIxS) reporting standard for genomic data. To facilitate the use of the GSC's MIxS reporting standard, we provide a description of the structure and terminology, how to navigate ontologies for required terms in MIxS, and demonstrate practical usage through a soil metagenome example.

This study examined the internal structure and internal consistency reliability of the Prison Group Climate Instrument (PGCI), by means of confirmatory factor analysis (CFA) and reliability analyses in a sample of 195 minors (92.8% male; aged 14–24; M = 17.6, SD = 1.52) in Kosovo and Albania. Findings showed an acceptable model fit for a three-factor model consisting of three correlated factors with good internal consistency reliability: Support (ω = .93), Growth (ω = .86), and Atmosphere (ω = .83), rather than the original four-factor model. The repression subscale did not fit participant’s perception, possibly due to cultural values favoring authority and respect for the rules. PGCI can be used to assess and monitor living group climate from the perspective of rehabilitation, facilitating future scientific research and continuous improvement of forensic residential care in these countries. [ABSTRACT FROM AUTHOR]

Background: Despite the benefits of exclusive breastfeeding, the proportion of exclusively breastfed children remains low in rural China. Self-efficacy is one of the most crucial modifiable factors predicting breastfeeding behavior. However, existing instruments in China do not specifically measure self-efficacy for exclusive breastfeeding but rather measure self-efficacy for any breastfeeding. Furthermore, they have been validated only in high-income Chinese settings. We sought to adapt and validate an instrument to measure exclusive breastfeeding self-efficacy within rural Chinese contexts. Methods: We introduced relevant items to Dennis' Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), which can assess maternal self-efficacy for exclusive breastfeeding. It was then implemented in a multistage random cluster sampling design and cross-sectional survey with home-visit interviews among women 0–6 months postpartum (n = 654) in the rural areas of four counties in Sichuan, China. We performed item-total and adjusted item-total correlations, as well as exploratory factor analysis to remove redundant items and determine the latent factor structure. We further applied confirmatory factor analysis to test the dimensionality of the scale. We then assessed the reliability of the scale and conducted tests of predictive and divergent validity. Known group comparisons were made by primiparous status and breastfeeding support level. We compared the validated Exclusive Breastfeeding Self-Efficacy Scale with the BSES-SF in terms of reliability and validity to explore the added value of scale modification. Results: Our modification of the BSES-SF to target exclusive breastfeeding produced 19 items. This was further reduced to 15 items based on adjusted item-total correlations and exploratory factor analysis, forming the Exclusive Breastfeeding Self-Efficacy Scale. This scale had three dimensions: "Breast milk supply and quality," "Breastfeeding skills," and "Exclusive breastfeeding" subscales. The Exclusive Breastfeeding Self-Efficacy Scale demonstrated strong internal consistency and overall reliability with a Cronbach's alpha coefficient of 0.91. Predictive and divergent validity and known group comparison assessments supported its validity. Robust psychometric evaluations demonstrated enhanced validity and reliability compared to the original BSES-SF. Conclusions: Our Exclusive Breastfeeding Self-Efficacy Scale is valid and reliable for measuring exclusive breastfeeding self-efficacy within rural Chinese contexts and is ready for adaptation and validation for clinical and programmatic use elsewhere, particularly within LMICs. [ABSTRACT FROM AUTHOR]

Background: Orthorexia nervosa (ON) is defined as a pathological fixation on eating healthy and pure food. In this study, it was aimed to evaluate the psychometric properties of the Turkish version of the Düsseldorf orthorexia scale (DOS) in a clinical sample. Methods: A total of 385 individuals, 117 with generalized anxiety disorder (GAD), 108 with major depressive disorder (MDD), 56 with obsessive–compulsive disorder (OCD) and 104 healthy controls, participated in the study. Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Yale–Brown Obsessive–Compulsive Scale (Y-BOCS), Eating Attitude Test (EAT-40), Orthorexia Nervosa Inventory (ONI) and Düsseldorf Orthorexia Scale (DOS) were applied to all participants. Results: The DOS demonstrated high internal consistency (Cronbach's alpha = 0.87) and good construct validity. Confirmatory factor analysis supported a one-factor structure, explaining a significant portion of variance among responses. In the analyses performed to test the convergent validity of DOS, a positive correlation was found with ONI and EAT scores (p < 0.001 for each). There was no significant correlation between DOS and HAM-D and HAM-A scores (p > 0.05 for each). The severity of orthorexic symptoms measured by DOS was similar between each patient group and healthy control group. DOS was applied to 70 more participants two weeks apart and the test–retest reliability was determined as 0.99. Conclusions: This study shows that the Turkish version of DOS is valid and reliable in clinical samples and healthy individuals, is largely consistent with ONI, and that this scale can be used in studies investigating ON. Plain English Summary: Orthorexia nervosa (ON) is a phenomenon in which there is intense effort to eat foods that are believed to be healthy and pure. It has been stated that there is a decrease in the professional, social and academic functionality of orthorexic individuals due to their efforts on healthy eating, and their physical health may be affected over time. Therefore, there is a need for an appropriate screening scale for rapid screening of orthorexic symptoms. The Düsseldorf orthorexia scale (DOS) is a self-report scale consisting of 10 questions created to assess ON. Our study is the first study to evaluate this scale in a Turkish clinical sample. The main aim of our study was to test the psychometric properties of DOS in patients diagnosed with major depressive disorder, generalized anxiety disorder and obsessive–compulsive disorder. The results showed that DOS had satisfactory psychometric properties in the Turkish clinical sample and could be a short, useful, and valid scale to screen for ON in these individuals. [ABSTRACT FROM AUTHOR]

Common carp, Cyprinus carpio, is a global invasive species illegally introduced into the Groenvlei system, South Africa, in the 1990s for recreational angling. To manage this population effectively, basic information is needed on its biology including growth and reproduction. This study examined the growth trends of C. carpio using otolith growth zone deposition rates which were validated using a chemical mark–recapture experiment (n = 16). From a total of 140 C. carpio, length-at-age was best described using the Von Bertalanffy growth model for males and females. The average lengths-at-50% maturity were estimated at 314 mm FL (males) and 262 mm FL (females). Compared with other South African C. carpio populations, the Groenvlei population is relatively fast growing and long lived, with the oldest female aged 20 years and the oldest male aged 18 years, likely facilitated by relatively favourable environmental conditions at Groenvlei. Data from this study provide a baseline at the commencement of C. carpio management interventions at Groenvlei and an opportunity to monitor changes in population dynamics facilitated by these efforts. [ABSTRACT FROM AUTHOR]

ABSTRACT Aim Design Methods Results Conclusion Implications for the Profession and/or Patient Care Impact Reporting Method Patient or Public Contribution Trial Registration To test the reliability and construct validity of the Mask Usability Scale in healthcare students and staff.A methodological study involving repeated measures.The study included two batches of participants: (1) 283 university nursing students and (2) 1753 participants composed of students (61%) and clinical staff (39%). All participants underwent N95 respirator fit tests and user seal checks. They also responded to the Mask Usability Scale, which comprises 11 items evaluated using Likert scales. The internal consistency was assessed using Cronbach's alpha and item–total correlation test. Test–retest reliability was evaluated by the intraclass correlation coefficient (ICC). The factor structure was initially identified through exploratory factor analysis (EFA), laying the groundwork for the model. This approach was followed by confirmatory factor analysis (CFA) to ensure the model fits with the standardised solution.Excluding items 9, 10 and 11, the study showed satisfactory internal consistency, evidenced by a Cronbach's alpha of 0.842 for the eight‐item scale from the combined samples. Factors, such as ‘Heat’, ‘Breathability’, ‘Tightness’ and ‘Ease in talking’ showed moderate to strong correlations. The test–retest reliability in the batch one sample was acceptable with ICCs ranging between 0.69 and 0.71 for different models. The EFA and fit indices supported a two‐factor structure. The first factor ‘Comfort and Usage’ included ‘Heat’, ‘Breathability’, ‘Tightness’, ‘Ease in talking’ and ‘Prolonged use’, which were keys for the usability of N95 respirators. The second factor ‘Suitability’ encompassed ‘Itchy’, ‘Easily displaced’ and ‘Ear soreness’. The variance explained by the first and second factors was 49% and 12%, respectively, with a strong inter‐factor correlation. The CFA results were satisfactory with fit metrics (NFI = 0.967, IFI = 0.969, TLI = 0.952, CFI = 0.969, RMSEA = 0.078 with 90% CI [0.069, 0.086] and p < 0.001) and a chi‐squared to df ratio of 13.58.The eight‐item mask usability scale exhibited satisfactory internal consistency and construct validity in both healthcare student and staff samples.The primary concern in the purchase policy of N95 respirators for clinical use is to strike the right balance between usability and fit rate (passing % of fit testing). Our study solidified the concept of quantifying the usability of respirators. With that mask usability scale measurement, a provision of benchmark and reference for the design and selection of respirators would be possible. This validated scale has significant implications for senior management in clinical settings and respirator manufacturers regarding the N95 respirator purchase policy and design.The results indicated the psychometric properties of mask usability scale in measuring the usability of N95 respirators. This scale is particularly valuable for assessing the perceptions of healthcare students and staff of factors, namely, ‘Heat’, ‘Breathability’, ‘Tightness’, ‘Ease in talking’, ‘Prolonged use’, ‘Itchy’, ‘Easily displaced’ and ‘Ear soreness’ concerning the use of N95 respirators.We adhered to EQUATOR guidelines following the STROBE statement.No patient or public contribution.ISRCTN registry: ISRCTN40115047 [ABSTRACT FROM AUTHOR]

AbstractBackgroundMethodsResultsConclusionDiagnosing acute disease in older adults is challenged by vague and atypical symptoms. Point-of-care tests (POCTs) at home may improve diagnostics and clinical decision-making. We compared various POCT devices to routine testing in acutely ill older adults to assess their clinical reliability.We enrolled participants aged 65+ years requiring acute in-home assessment with signs of acute conditions. Venous and capillary blood samples were collected and analysed on-site using POCT, while identical samples were transported and analysed in a routine laboratory. Agreement between POCT and laboratory testing was assessed using scatter plots with linear regression, Pearson’s correlation coefficient (PCC), limits of agreement, and Bland-Altman plots. Misclassification rates were calculated based on clinically meaningful cut-offs to assess POCT’s clinical reliability.We included 100 participants with a mean age of 81.6 (±8.4 SD) years. Strong correlation was found between POCT and routine measurements (PCC: 0.76–0.94 for capillary samples and 0.85–0.98 for venous samples). Venous samples showed higher PCC than capillary, except for neutrophils (0.93 for capillary, 0.89 for venous). Misclassification occurred in capillary samples for haemoglobin (10/62) and total WBC (6/50), while in venous samples, misclassification was observed for haemoglobin (4/54), total WBC (4/50), K+ (5/47), urea (5/47), and creatinine (3/42). No misclassification was observed for Na+.POCT provides acceptable, clinically reliable measurements in acutely ill older adults, potentially enhancing diagnostics and treatments during in-home assessment. Venous blood testing is preferable due to a lower misclassification rate, but capillary blood remains a pragmatic alternative, despite higher variation and inaccuracy. [ABSTRACT FROM AUTHOR]

The primary aim of this study was to investigate the construct validity of a survey focussing on the use of technology and teaching techniques to promote religious moderation, employing exploratory factor analysis (EFA). A total of 116 educators, who teach character development courses, were recruited to participate in the study. The developed instrument is based on the Technology Pedagogical Content Knowledge (TPACK) framework and has been validated through expert and cognitive interviews with religious education lecturers. The study’s results demonstrate that participants were able to discern conceptual distinctions between TPACK domains. Four factors were identified: TPACK, Pedagogical Content Knowledge (PCK), Technological Knowledge (TK), and Pedagogical Knowledge (PK). TPACK encompasses both Technological Pedagogical Knowledge (TPK) and Technological Content Knowledge (TCK), while PCK includes Content Knowledge (CK). Additionally, Rasch statistical analysis was employed to determine that the instrument measures a single latent variable, namely religiously moderated TPACK, with high reliability based on the fit of the scale to the Rasch model. The statistical data from the EFA and Rasch analyses suggest that this survey can serve as a valuable tool for researchers and educators interested in exploring TPACK within the context of religious moderation. [ABSTRACT FROM AUTHOR]

Background: The German version of the SarQoL®, a sarcopenia-specific quality of life (QoL) questionnaire, has not been validated hindering its widespread use. This study aimed to evaluate the psychometric properties of the German SarQoL®. Methods: Via a cross-sectional study participants were recruited in two geriatric outpatient facilities and one acute geriatric ward in Munich (Germany). Sarcopenia and probable sarcopenia were diagnosed with the European Working Group on Sarcopenia in Older People (EWGSOP2) algorithm. From 185 participants (age 79.8 ± 6.1), 77 had probable sarcopenia, and 51 had sarcopenia. Participants completed the SarQoL® and the European Quality-of-Life 5-Dimension (EQ-5D) questionnaires. The validation included examination of the discriminative power, construct validity, internal consistency, test-retest reliability, and floor/ceiling effects. Results: Lower SarQoL®scores for sarcopenic (p = 0.002) and probable sarcopenic subjects (p < 0.001) compared to controls indicated good discriminative power. Consistent construct validity was found for sarcopenic subjects: moderate to high correlations with domains capturing similar constructs of the EQ-5D: 'Activities of daily living' (r = -0.58, p < 0.001), 'Mobility' (r = -0.72, p < 0.001) and low correlations with domains related to different constructs like 'Pain' (r = -0.32, p < 0.022). Similar correlations were found for probable sarcopenic subjects. The Cronbach's alpha was 0.8. Test-retest reliability was excellent (intraclass coefficient correlation of = 0.96; 95% CI = 0.91–0.99), and no floor/ceiling effects were observed. Conclusion: QoL was similarly reduced in both patient cohorts compared to controls. The German SarQoL® is a valid and reliable instrument for measuring QoL in patients > 65 years of age with sarcopenia and probable sarcopenia and can now be used in epidemiological studies and clinical trials in a German-speaking population. Trial registration: German Clinical Trials Register (DRKS)-ID: DRKS00020504 (March 12th, 2021). [ABSTRACT FROM AUTHOR]

Background: Work-related sense of coherence (Work-SoC) is defined as the perceived comprehensibility, manageability and meaningfulness of an individual's work situation. The purpose of this study was to investigate the factor structure, invariance, reliability, and validity of the Polish version of the Work-SoC Scale. Method: The research was carried out between September and November 2023 in a diverse sample of employees. Factor structure, internal consistency, and measurement equivalence analysis were performed on sample N1 = 622. Criterion validity was checked on sample N2 = 255. Temporal stability was checked on sample N3 = 60 using the test-retest method. Results: A three-factor solution was the best fit for the data, and invariant across sex, age, occupational group, and education. The Work-SoC was strongest in white-collar workers. Strength of Work-SoC was positively related to seniority (r = 0.23, p < 0.001). The reliability of the Work-SoC Scale was high (α = 0.84, ω = 0.84). Work-SoC was positively correlated with general SoC (r = 0.36, p < 0.001) and job satisfaction (r = 0.50, p < 0.001), and negatively correlated with job burnout (r = -0.32, p < 0.001). The temporal stability of the measurement for the overall scale was high (r = 0.80, p < 0.001). Conclusion: The Polish adaptation of the Work-SoC Scale has an identical structure and is as reliable as the original version. The high criterion validity, measurement stability, and the invariant structure of the scale by sex, age, occupational group, and education suggest that the Work-SoC Scale is a valuable tool for future research on employee health. [ABSTRACT FROM AUTHOR]

Promoting sustainability within university institutions entails conducting assessments to lay the groundwork for developing educational methodologies. This article presents the validation of a quantitative 36-item scale questionnaire to measure university students' perceptions towards sustainability. A total of 285 university students from different Spanish Universities participated in completing the questionnaire. The reliability and validity of the instrument were statistically assessed through Cronbach's alpha and confirmatory factor analysis. The questionnaire is of mixed character, combining 6-point Likert scale questions (ranging from "Strongly disagree" to "Strongly agree"), closed and open-ended questions. It was structured into six dimensions: knowledge, attitude, willingness to act, behavior, self-efficacy, and affective. The first five dimensions were confirmed by a confirmatory factor analysis, demonstrating a good fit level in the model (RMSEA = 0.043, CFI = 0.972, SRMR = 0.076, TLI = 0.970 and X2/df = 1.45), while the affective dimension was analyzed using a qualitative approach. Internal reliability, found using Cronbach's alpha, varies between 0.737 and 0.909. The results show that the instrument meets the validity and reliability criteria. Consequently, a valuable tool for academic utilization is suggested, offering a diagnostic and monitoring mechanism for evaluating sustainability perceptions, a topic that has recently garnered significant attention. [ABSTRACT FROM AUTHOR]

Background: The personal qualities of health workers determine the way health services are provided to clients. Some key personal qualities (also called behavioural competencies) of physicians that contribute to quality healthcare delivery include ethical responsibility, empathy, patient-centeredness, diligence, good judgment, respectful, teamwork, team leadership/conflict management, ability to take correction and tolerance. In this study, we developed and validated clinical scenarios (dilemmas) for assessing priority behavioural competencies for medical practice in Nigeria. Methods: Drawing on prioritized competencies generated via a scoping review and nominal group technique (NGT) exercises in a previous study in the study series, Faculty members from the University of Nigeria Teaching Hospital were consulted to develop or adapt clinical scenarios that could be used to assess these competencies in a physician. The clinical scenarios and options were framed as situational judgement tests (SJTs) and these tests were administered to a random sample of 192 undergraduate and 111 postgraduate medical doctors in a tertiary hospital in Enugu State. Using Kane's validity argument framework, we assessed scoring and generalization inferences of situational judgment tests (SJT) based on the developed scenarios. Result: Scoring inference – difficulty and discrimination index – shows that most of the SJT items are good test items and can differentiate between high and low performers. The corrected point biserial correlations show positive correlation for most of the items. Generalization inference shows the items represent the domains of interest and are internally consistent. However, few items that show poor difficulty and discrimination index were subjected to re-evaluation and possible elimination. Conclusion: This study has produced a set of valid clinical scenarios that can be used to evaluate specific behavioural competencies among trainee medical doctors. It demonstrates that SJTs can be used to assess behavioural competencies for medical practice. However, further research is needed to establish the applicability of SJT beyond the immediate context, such as the medical school, in which it is developed. [ABSTRACT FROM AUTHOR]

AbstractOlopatadine Hydrochloride, a H1-receptor antagonist, widely used for Allergic Conjunctivitis. A HPLC method was created and validated for the quantification of olopatadine hydrochloride and its related substances in eye formulation in accordance with ICH standards. The separation of olopatadine hydrochloride was done by using a 4.6-mm 15-cm; 5 µm packing USP L7 column with a mobile phase made up of a mixer of phosphate buffer, pH 3.0: Acetonitrile (72:28) ratio at a flow rate of 1.0 mL/min and injection volume 30 µL. A photodiode array detector was used at a wavelength of 299 nm. The validation parameters including specificity, LOD/LOQ, linearity, accuracy, precision, robustness, and solution stability, were verified for performance of the method. The linearity ranges were 0.02–0.40, 0.0004–0.008 and 0.0001–0.002 mg/mL for olopatadine hydrochloride, olopatadine-related compound B and olopatadine carbaldehyde, respectively. The % recovery was within the 80–120%. When the column temperature and flow rate were changed, the system suitability resolution was still within the acceptable range. The solutions were stable after 24 hr at both room temperature and 5°C temperature. For the analysis of olopatadine hydrochloride and its impurity in pharmaceutical finished eye dosage form, the confirmed HPLC method can be a workable analytical approach. [ABSTRACT FROM AUTHOR]

Summary Validated predictions of wildlife population density would be very useful for managers of overabundant wildlife and their effects on biodiversity. In this study such predictions were generated by modelling population dynamics of 18 non‐culled populations of Eastern Grey Kangaroos (Macropus giganteus) across small biodiversity conservation reserves in Canberra. Predictions were validated using three analyses of independent, out‐of‐sample, data from 11 populations which were non‐culled or culled. Association (analysis 1) showed observed and predicted densities were significantly positively correlated (R2 = 0.79, P = 0.045, n = 5) with unbiased slope and y intercept for non‐culled populations, though observed and predicted densities of culled populations were unrelated (R2 = 0.32, P = 0.24, n = 6). Coverage (analysis 2) showed predicted densities were within the 95% confidence interval of observed densities in five of five non‐culled populations and four of six culled populations, with one underestimate and one overestimate in the latter group. Bias (analysis 3) showed the mean bias (=observed – predicted) was 0.18 (±0.23 SE) kangaroos/ha for non‐culled and 0.08 (±0.23 SE) for culled populations. The results have been used to adjust kangaroo management approaches in Canberra as part of adaptive management. [ABSTRACT FROM AUTHOR]

This study aimed to validate the Croatian version of the Adverse Childhood Experiences Questionnaire 10-item version (ACE-10) in a sample of 293 emerging adults (mean age 22 years old; 56.9% women). ACE-10 is a self-report retrospective questionnaire that assesses abuse, neglect, and household dysfunction. Measures of depression, anxiety, stress, and resilience were included to assess concurrent validity. The results confirmed the expected two-factor structure, displaying robust psychometric properties and concurrent validity. The ACE-10 proves reliable, making it well-suited for examining adverse childhood experiences in Croatian samples. [ABSTRACT FROM AUTHOR]

The importance of socioemotional teaching skills has been highlighted for its link with better academic, social, emotional, and behavioral results of students, as well as for its contribution to the work wellbeing, mental health, and prosperity of teachers. However, there are few instruments that measure these skills in teachers in the context of their professional practice. The purpose of this research was to analyze the psychometric properties of the socioemotional Skills Instrument for Teachers (SEMS-IT). An instrumental design and a sample of 853 Chilean secondary school teachers were used. To evaluate the dimensional structure of the instrument, a portion of the sample (n = 468) underwent a network estimation method with exploratory graph analysis (EGA) using a Gaussian GLASSO model. Then, in order to confirm the structural consistency and stability of the items, the analysis was replicated in a second sample (n = 385), where these results were additionally contrasted with those of the confirmatory factor analysis (CFA). The EGA findings confirmed a structure of four dimensions and 19 items in total: (a) cognitive management of teacher emotion (four items), (b) teacher empathic concern (four items), (c) teacher–student relationship (four items), and (d) adverse classroom climate (seven items), with a 7-point Likert scale response format. The CFA showed good and acceptable fit indicators, X2 (171) = 354.546 (p < 0.001), Comparative Fit Index (CFI) = 0.971, Tucker–Lewis index (TLI) = 0.966, Root Mean Square Error of Approximation (RMSEA) = 0.061, and Standardized Root Mean Square Residual (SRMR) = 0.062. In conclusion, a tool for the assessment of teachers' socioemotional skills, valid for school-based educational research, is provided. Implications of the findings at the theoretical and practical levels are discussed, as well as limitations and future projections for future research. [ABSTRACT FROM AUTHOR]

Background: Evidence-based practice (EBP) lowers costs, guarantees staying current with new technology and abilities, and enables the provision of high-quality care. Evidence-based practice (EBP) considered the foundation for safe patient care. Aim: is to validate and carry out the linguistic-cultural adaptation of the S-EBPQ for the Arabic language. Design: A methodological study design was used. Method: There were two primary stages: translation and validation. Three experts reviewed the contents during the translation and validation in order to ensure their relevancy. 15 nursing students conducted face validation to confirm the produced items' clarity and understandability. Reliability assessment was achieved by conducting a pilot study on 72 nursing students. Ethical approval was taken. For statistical analysis, SPSS software was used. The internal reliability of the questionnaire was evaluated using Cronbach's Alpha. The Pearson Correlation was used to test the relationship between the student's score on the questionnaire and their age and gender. Results: The Scale-Content Validity Index was 0.90; Cronbach's Alpha value was 0.963. Students in face validation phase confirmed that wording, clarity, and understandable language of the items were achieved. The Mean of students total score was 80.2 (SD = 21.5). Pearson test revealed that there was a weak positive correlation between students' scores and age R = 0.320 (p = 0.001). Also, it demonstrated that there was no correlation between the students' scores and the gender R =—0,028 (p = 0.817). Conclusion: The Arabic version of the S-EBPQ generally had a solid structure and it demonstrated high validity and reliability. The questionnaire could be used in future studies. [ABSTRACT FROM AUTHOR]

Whilst western diet and sedentary lifestyles heavily contribute to the global obesity epidemic, it is likely that chemical exposure may also contribute. A substantial body of literature implicates a variety of suspected environmental chemicals in metabolic disruption and obesogenic mechanisms. Chemically induced obesogenic metabolic disruption is not yet considered in regulatory testing paradigms or regulations, but this is an internationally recognised human health regulatory development need. An early step in the development of relevant regulatory test methods is to derive appropriate minimum chemical selection lists for the target endpoint and its key mechanisms, such that the test method can be suitably optimised and validated. Independently collated and reviewed reference and proficiency chemicals relevant for the regulatory chemical universe that they are intended to serve, assist regulatory test method development and validation, particularly in relation to the OECD Test Guidelines Programme. To address obesogenic mechanisms and modes of action for chemical hazard assessment, key initiating mechanisms include molecular-level Peroxisome Proliferator-Activated Receptor (PPAR) α and γ agonism and the tissue/organ-level key event of perturbation of the adipogenesis process that may lead to excess white adipose tissue. Here we present a critical literature review, analysis and evaluation of chemicals suitable for the development, optimisation and validation of human PPARα and PPARγ agonism and human white adipose tissue adipogenesis test methods. The chemical lists have been derived with consideration of essential criteria needed for understanding the strengths and limitations of the test methods. With a weight of evidence approach, this has been combined with practical and applied aspects required for the integration and combination of relevant candidate test methods into test batteries, as part of an Integrated Approach to Testing and Assessment for metabolic disruption. The proposed proficiency and reference chemical list includes a long list of negatives and positives (20 chemicals for PPARα, 21 for PPARγ, and 11 for adipogenesis) from which a (pre-)validation proficiency chemicals list has been derived. [ABSTRACT FROM AUTHOR]

The genus Allium is a prominent member of the Amaryllidaceae family and encompasses approximately 1,063 species worldwide. These diverse species vary in appearance and flavor but they share biochemical similarities. Underutilized Alliums present a promising alternative to onion and garlic in various Indian regions, given their adaptability, versatile utility, and nutraceutical properties. Their adaptation in the plains of India is a great opportunity to add medicinal and nutraceutical value to Indian cuisine. Therefore, the present study aimed to evaluate the underutilized raw Allium leaves for their sensory perception by hedonic test (n = 60), consumer perceptions and willingness to purchase (n = 180), and the development and validation of value chain model (n = 30) to popularize these species in plains. For the various sensory attributes evaluated, Allium tuberosum Kazakhstan CGN-1587 emerged out to be the most suitable for its advancement into the consumer survey. The consumer perception study recorded 74.44% willingness to purchase of total respondents and a majority preference for consuming it in cooked form (38.30%). A value chain model of Allium tuberosum Kazakhstan CGN-1587 with supply chain agencies was subsequently developed. Validation of this value chain model was done with a panel of different stakeholders. Panelists perceived the value chain as highly valid, particularly in terms of economic feasibility (4.30 ± 0.70) and sustainability (4.20 ± 0.81). Thus, the present study provides valuable insights that can support and promote the use of underutilized Alliums in non-traditional areas of India. [ABSTRACT FROM AUTHOR]

Background: Osteonecrosis of the jaw (ONJ) stands as a severe complication linked to the use of bisphosphonates, particularly zoledronic acid, which is widely prescribed for managing conditions like osteoporosis and bone metastasis. This study is geared towards the development and validation of a clinical prediction model for ONJ in patients undergoing zoledronic acid treatment. Methods: We harnessed data from the FDA Adverse Event Reporting System (FAERS) as our training dataset, while the Canada Vigilance Adverse Reaction (CVAR) database served as the testing dataset. The study encompassed patients treated with zoledronic acid and subsequently diagnosed with ONJ. We analysed a range of predictive factors, including breast cancer, bone metastasis, osteoporosis, vitamin D and calcium levels, comorbidities, the number of concomitant medications, dosage, age, weight, and gender. Logistic regression and nomogram analysis were the chosen methodologies for constructing the predictive model. To evaluate the model's performance, we utilized receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). Results: The study encompassed a total of 2,126 patients in the training cohort, 911 patients in the internal test cohort from the FAERS database, and 121 patients in the external test cohort from the CVAR database. Notable predictors for ONJ included bone metastasis (OR: 1.65, 95% CI: 1.22–2.24), osteoporosis (OR: 0.33, 95% CI: 0.21–0.52), the number of concomitant medications (OR: 1.07, 95% CI: 1.05–1.09), and the dosage of zoledronic acid (OR: 1.24, 95% CI: 1.10–1.39). The nomogram exhibited robust discriminatory power, evidenced by an area under the curve (AUC) of 0.77 in the training cohort, 0.76 in the internal test cohort, and 0.90 in the external test cohort. Calibration plots demonstrated a strong alignment between observed and predicted probabilities. Furthermore, DCA highlighted the prediction model's significant net benefit across various threshold probabilities. Conclusion: By leveraging data from both the FAERS and Canadian databases, this study has successfully developed and validated a clinical prediction model for ONJ in patients receiving zoledronic acid. This model stands as a valuable tool for clinicians, enabling them to pinpoint high-risk patients and make evidence-based treatment decisions to minimize the risk of ONJ. [ABSTRACT FROM AUTHOR]

Objective: To assess the psychometric properties of the Spanish King's Parkinson's Disease Pain Scale (KPPS). Design: A descriptive transversal study at a Spanish hospital. Methods: Fifty‐three Parkinson's disease (PD) patients suffering from otherwise explained pain (34 females, age = 63.42 ± 10.52 years, time with disease = 7.25 ± 4.65 years) were evaluated by the KPPS, Brief Pain Inventory (BPI), two Pain Pressure Thresholds (PPTs), Widespread Mechanical Hyperalgesia (WMH), and Conditioned Pain Modulation (CPM). A retest of the KPPS was performed 7–15 days later. Internal consistency, test–retest reliability (intraclass correlation coefficient (ICC)), measurement error, factor structure, and criterion/convergent validity were assessed. Results: Internal consistency of the Spanish KPPS was acceptable (Cronbach's alpha = 0.77). The mean test and retest total KPPS scores were similar (test = 34.83 ± 23.50 points, retest = 35.87 ± 26.23 points), and test–retest reliability was good (ICC = 0.85, 95% CI = 0.75–0.91). Standard error of measurement (SEM) was 9.1 points and smallest detectable change (SDC) was 25.22 points. The sampling adequacy was not sufficient to perform factor analysis. The total KPPS score was not correlated to the BPI intensity subscale (r = 0.18, p = 0.19), but it was moderately and positively correlated to the interference subscale (r = 0.43, p = 0.001). The total KPPS was moderately and negatively correlated to both the remote PPT (r = −0.4, p = 0.003) and WMH (r = −0.38, p = 0.005). No statistical correlations were found with local PPT or CPM. Conclusion: The present study provides evidence that the Spanish KPPS effectively measures pain in individuals with PD, with its total score demonstrating good reliability, minimal measurement error, and adequate criterion and convergent validity. [ABSTRACT FROM AUTHOR]

AbstractPurposeMaterials and methodsResultsConclusion\nIMPLICATIONS FOR REHABILITATIONTo evaluate the measurement properties of the Arabic Patient-Specific Functional Scale (PSFS) in individuals with upper extremity musculoskeletal disorders.Participants with upper extremity musculoskeletal disorders (N = 139) completed the PSFS, Upper Extremity Functional Index (UEFI), the Disabilities of the Arm, Shoulder and Hand (DASH), Numeric Pain Rating Scale (NPRS) and the Global Assessment of Function scale (GAF). The same outcome measures were completed again with one week in addition to the Global Rating of Change Scale. The test-retest reliability, measurement error, floor and ceiling effects, and construct validity of the PSFS were examined.The PSFS demonstrated very good test-retest reliability (ICC2,1 = 0.82; 95% CI: 0.71–0.88), with no evidence of floor or ceiling effects. The standard error of measurement was determined to be 0.74 while the minimal detectable change was 1.73 points. The PSFS demonstrated significant negative correlation with DASH, NPRS (−0.58, −0.35), and significant positive correlation with the UEFI and GAF (0.56, 0.50). The PSFS demonstrated statistically higher correlation with the DASH and UEFI compared with the NPRS (p < 0.004) supporting our predefined construct validity hypotheses.The Arabic PSFS is an applicable, reliable, and valid outcome measure of upper-extremity activity limitations for patients with upper extremity musculoskeletal disorders.Patients who exhibit no changes in their clinical condition will consistently exhibit similar scores in the Arabic Patient-Specific Functional Scale (PSFS) when the scale is administered multiple times over a period of time.A patient’s score in the Arabic PSFS can be accurately interpreted by rehabilitation professionals to reflect the degree of activity limitation with confidence.The Arabic PSFS can be effectively utilized in both daily clinical practice and research studies to accurately measure the extent of activity limitation experienced by Arabic-speaking individuals with upper extremity musculoskeletal disorders.The Arabic PSFS allows rehabilitation professionals to quantitatively assess activity limitation in a manner that is culturally and lifestyle-appropriate for Arabic-speaking individuals with upper extremity musculoskeletal disorders.Patients who exhibit no changes in their clinical condition will consistently exhibit similar scores in the Arabic Patient-Specific Functional Scale (PSFS) when the scale is administered multiple times over a period of time.A patient’s score in the Arabic PSFS can be accurately interpreted by rehabilitation professionals to reflect the degree of activity limitation with confidence.The Arabic PSFS can be effectively utilized in both daily clinical practice and research studies to accurately measure the extent of activity limitation experienced by Arabic-speaking individuals with upper extremity musculoskeletal disorders.The Arabic PSFS allows rehabilitation professionals to quantitatively assess activity limitation in a manner that is culturally and lifestyle-appropriate for Arabic-speaking individuals with upper extremity musculoskeletal disorders. [ABSTRACT FROM AUTHOR]

This chapter (Sampling as Part of the Measurement Process) is a contribution to the Geostandards and Geoanalytical Research Handbook of Rock and Mineral Analysis – an online textbook that is a fully revised and updated edition of A Handbook of Silicate Rock Analysis (P. J. Potts, 1987, Blackie, Glasgow).Chapter 1 (Part 2) forms part of Section 1 of the handbook dealing with fundamentals of measurement and instrument design. The geochemical measurement process is considered to begin when the primary sample is taken from the sampling target, rather than when that sample arrives at the laboratory. This integration of sampling within the measurement procedure enables both sampling and chemical analysis to be optimised in order to achieve a measurement procedure that is fit for its intended geochemical purpose. The key metric in judging this fitness for purpose, and hence validating a measurement procedure, is the uncertainty of each measurement value. This measurement uncertainty is explained, together with methods to estimate and express it in a way that includes the contribution from sampling, with a worked example. The resultant more realistic estimates of measurement uncertainty are shown to improve the reliability of the geochemical interpretation of measurement values. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to develop and validate the Brief Eating Self-Efficacy Scale (ESEBS-BR) in Brazilian Portuguese, addressing the lack of tools to assess eating self-efficacy beliefs in Portuguese-speaking populations. Method: The study sought to cross-culturally adapt the scale, evaluate its internal structure, validate its reliability and validity, and explore potential associations between eating self-efficacy and eating behaviors. The cross-cultural adaptation process involved translation and back-translation, expert committees, and pre-testing. Scale validation was conducted with 228 participants, including reliability analyses, confirmatory factor analysis, and correlations with established measures of eating behavior. Results: The ESEBS-BR, maintaining all 8 original items, demonstrated high reliability, with a two-factor structure model confirmed by confirmatory factor analysis. Significant correlations were found between ESEBS-BR scores and measures of binge eating and eating behaviors, validating its criterion validity. Conclusions: The development and validation of the ESEBS-BR represent a significant contribution to the assessment of eating self-efficacy in the Brazilian population. The scale proved to be sensitive, reliable, and valid, offering an important tool for research and clinical interventions related to eating behavior. Level of evidence: V, descriptive cross-sectional study. [ABSTRACT FROM AUTHOR]

Introduction: All cosmetic ingredients must be evaluated for their safety to consumers. In the absence of in vivo data, systemic concentrations of ingredients can be predicted using Physiologically based Pharmacokinetic (PBPK) models. However, more examples are needed to demonstrate how they can be validated and applied in Next-Generation Risk Assessments (NGRA) of cosmetic ingredients. We used a bottom-up approach to develop human PBPK models for genistein and daidzein for a read-across NGRA, whereby genistein was the source chemical for the target chemical, daidzein. Methods: An oral rat PBPK model for genistein was built using PK-Sim® and in vitro ADME input data. This formed the basis of the daidzein oral rat PBPK model, for which chemical-specific input parameters were used. Rat PBPK models were then converted to human models using human-specific physiological parameters and human in vitro ADME data. In vitro skin metabolism and penetration data were used to build the dermal module to represent the major route of exposure to cosmetics. Results: The initial oral rat model for genistein was qualified since it predicted values within 2-fold of measured in vivo PK values. This was used to predict plasma concentrations from the in vivo NOAEL for genistein to set test concentrations in bioassays. Intrinsic hepatic clearance and unbound fractions in plasma were identified as sensitive parameters impacting the predicted Cmax values. Sensitivity and uncertainty analyses indicated the developed PBPK models had a moderate level of confidence. An important aspect of the development of the dermal module was the implementation of first-pass metabolism, which was extensive for both chemicals. The final human PBPK model for daidzein was used to convert the in vitro PoD of 33 nM (from an estrogen receptor transactivation assay) to an external dose of 0.2% in a body lotion formulation. Conclusion: PBPK models for genistein and daidzein were developed as a central component of an NGRA read-across case study. This will help to gain regulatory confidence in the use of PBPK models, especially for cosmetic ingredients. [ABSTRACT FROM AUTHOR]

Background: Health economic appraisals often rely on the assessment of health utilities using preference-based measures (PBM). The cancer-specific PBM, European Organisation for Research and Treatment of Cancer Quality of Life Utility — Core 10 Dimensions (EORTC QLU-C10D), was developed recently, and now needs to be validated in various clinical populations. Methods: In a multicenter, multinational prospective cohort study, we longitudinally collected EORTC QLQ-C30 and EQ-5D-5L data from patients with thyroid cancer. We applied seven country-specific value sets to the QLQ-C30 data to derive country-specific utility values and used the EQ-5D-5L as a comparator PBM. Criterion validity was assessed by correlating index scores and Bland–Altman plots. Construct validity was investigated by correlating domain scores. Known-group comparisons and responsiveness were assessed using external clinical criteria. Results: A total of 181 patients with thyroid cancer from nine countries (three continents) provided analyzable data. Patients were included if they had differentiated, medullary, or anaplastic thyroid cancer. Mean utility values of both instruments were generally lower compared to general population norms. No floor or ceiling effects were present for the QLU-C10D. The intra-class correlation for EQ-5D-5L and QLU-C10D index values ranged from 0.761 to 0.901 across the measurement timepoints, supporting criterion validity. Spearman's correlation coefficients ranged from 0.289 to 0.716 for theoretically corresponding domain pairs. The QLU-C10D detected differences in 9 of 15 known-group comparisons, supporting sensitivity. Clinically important changes were detected by all QLU-C10D country specific value sets, supporting responsiveness. Further, the QLU-C10D had higher statistical efficiency than the EQ-5D-5L in 74.7% of comparisons. Conclusions: The QLU-C10D is a valid PBM for health economic evaluations in thyroid cancer studies. We recommend its use to estimate health utilities in economic evaluations of thyroid cancer therapies. [ABSTRACT FROM AUTHOR]

Background: Monitoring health-related physical fitness (HRPF) may benefit proactive Inflammatory Bowel Disease (IBD) management. However, knowledge regarding HRPF in patients with IBD is limited and gold standard tests are impractical for widespread use, necessitating simpler methods. Aim: This study evaluated the criterion validity of screening tools and field-based tests compared to gold standard tests for HRPF in patients with IBD. Methods: Adult patients with IBD completed screening tools, field-based tests, and gold standard tests for HRPF. Criterion validity was examined through (intraclass) correlation coefficients and Bland–Altman plots. Predictive capacity of the screening tools was examined with receiver operating curve analysis. Results: Among 53 included patients, screening tools demonstrated poor-to-moderate validity compared to the cardiopulmonary exercise test (CPET) for cardiorespiratory fitness. Very strong correlations were found for four-site skinfold thickness and multi-frequency bioimpedance analysis (BIA) with deuterium oxide dilution for body fat percentage (ICC = 0.90, ICC = 0.93), and between the steep ramp test and CPET (r = 0.95) for cardiorespiratory fitness. The steep ramp test also correlated strongly with isokinetic quadriceps (r > 0.75) and hamstring (r > 0.74) strength. Hand-held dynamometry and the sit-to-stand test showed strong correlations with hamstring strength (r > 0.80, r > 0.76). Negligible correlations were found for field-based tests compared to isokinetic quadriceps and hamstring endurance. Conclusions: Four-site skinfold thickness and BIA showed good agreement with the gold standard for body fat measurement. The steep ramp test demonstrated strong correlations with the gold standard tests for cardiorespiratory fitness and quadriceps and hamstring strength, while hand-held dynamometry and the sit-to-stand test showed strong correlations with hamstring strength. [ABSTRACT FROM AUTHOR]

The Scoliosis Research Society SRS-22 questionnaire is a standard tool to assess the Health-Related Quality of Life (HRQoL) in scoliosis patients but, because of cultural differences limited use among Arabic patients. The aim is to perform a cross-cultural adaptation and validation of Arabic version of Scoliosis Japanese Questionnaire-27 and test it on Saudi patients with adolescent idiopathic scoliosis (AIS). This a cross sectional study run between July 2021 and December 2022 recruited 194 patients. The cross-cultural adaptation process was performed using the American Association of Orthopedic Surgeons (AAOS) Outcomes Committee method. All patients had completed the Arabic version of Scoliosis Japanese Questionnaire-27 and SF-12 preoperatively and 3-month postoperatively. The validity and internal consistency were tested using the Intraclass correlation coefficient (ICC), Cronbach alpha, Pearson correlation coefficient, and confidence interval (CI). We analyzed the result of 194 female adolescent patients. The average age is 14 ± 2.4 years (range from 10 to 21 years). The majority of patients have a Lenke type 1 curve (54 %). The overall Cronbach alpha (CA) of all domains of Scoliosis Japanese Questionnaire-27 is 0.92. However, the Cronbach alpha for the mental health (Q17,18,20,21,23,24) and, self-image (Q12-14,22,25,26) are 0.93 and 0.84 respectively. The Arabic version of Scoliosis Japanese Questionnaire-27 is a reliable and valid instrument and can be applied to evaluate the quality of life in patients with AIS. [ABSTRACT FROM AUTHOR]

Introduction: Acne is the most frequent chronic inflammatory skin condition in adolescence but occurs also in later age. Our study aimed to characterise the epidemiology, geographical distribution, comorbidity and healthcare of acne juvenilis (AJ) and acne tarda (AT). Methods: Statutory health insurance (SHI) data from 2016 to 2020 were analysed. Prevalence rates, including geographical distribution, comorbidities and drug use by specialists group, were measured. Results: In 2020, the prevalence of acne among adults was 1.50% (AT > 25 years) and among adolescents was 3.88% (AT ≤ 25 years). The highest prevalence (13.02%) was observed at the age of 17 years. Sex differences were higher in AT (73.80% in women) than in AJ (64.55% in women). Compared with non-affected persons, individuals with acne – in particular with AT – showed significantly higher rates of skin-related comorbidities, including folliculitis (rate ratio (RR) 8.89), pyoderma (RR 7.27) and rosacea (RR 5.53), and non-skin-related comorbidities, such as ovarian dysfunction (RR 2.36), rhinitis allergica (RR 1.84) and Crohn's disease (RR 1.79). Preferred systemic therapeutics prescribed were anti-infectives in AT (46.86%) and retinoids in AJ (52.35%). In the majority of cases, dermatologists were involved in the treatment of acne (AT 65.77%; AJ 76.27%). The most commonly prescribed topical agents were adapalene with benzoyl peroxide (AT 87.72%; AJ 85.75%), while systemic isotretinoin (AT 81.20%; AJ 90.06%) was also a frequently used drug. General practitioners were more likely to prescribe anti-infectives, especially topical antibiotics such as chlortetracycline (AT 52.38%; AJ 44.44%) and systemic antibiotics, especially tetracycline (AT 58.33%; AJ 67.50%). Conclusion: Acne affects a relevant proportion of the German population not only in adolescence, and management of this inflammatory skin disease does not naturally follow medical guidelines or specialist recommendations. These findings emphasise the importance of specialised care and comprehensive therapeutic management that should also consider the exploration of comorbidities. Plain Language Summary: We performed an analysis on the frequencies of illness and concomitant diseases of acne in Germany based on health insurance data. Furthermore, the treatment of acne in regard to drug choices and prescribers was characterised. In 2020, about 2 million people in Germany had acne. The mean age was 31 years, and women were more often affected (68.58%). The highest proportion of acne was observed at the age of 17 years (13.02%). Overall, adolescent acne (younger than 25 years) was more frequent than adult acne (older than 25 years). People with acne, especially with adult acne, had higher rates of concomitant diseases (compared with non-affected persons, both related to the skin and beyond). About a third of people with acne were not treated by a dermatologist, and the majority of these patients were not treated according to guidelines. In conclusion, acne and related concomitant diseases affect a relevant proportion of adolescents and adults in Germany. The high prevalence of adult acne suggests a special focus also on this age group, including exploration of hormonal and psychological disorders. Early and effective treatment, adapted to the severity of the acne, can prevent complications such as scarring. [ABSTRACT FROM AUTHOR]

Background: The evaluation of Theory of Mind (ToM) in the clinical setting remains limited due to the lack of valid instruments for a quick and reliable assessment. In this study, the psychometric properties of the Yoni-36 task were tested, and correction grids, equivalence scores, and normative data were computed. Methods: In total, 318 healthy subjects (169 females; mean age = 42.22 ± 18.11 years; mean education = 15.01 ± 3.43 years) were enrolled and administered the Yoni-36 task. Results: Statistical analysis showed good-to-high internal consistency, split-half reliability, and discrimination ability (especially for the second-order items) of the Yoni-36 task. Regression models highlighted the predictive role of age and education on second-order, affective, cognitive accuracy, and response time scores. Education influenced the first-order ToM response time score as well. Based on β values of the regressions, raw scores of the Yoni task were adjusted for sex, age, and education, and correction grids were computed. The equivalent scores indicated an accuracy index score < 0.69 and a response time index score < 0.83 as cut-off points for ToM competence. Normative data reported a mean accuracy and response time index score of 0.90 ± 0.11 and 0.91 ± 0.05 in the Italian population, respectively. Conclusions: The Yoni-36 proved to be a valid instrument for a quick and reliable ToM assessment, suitable to be included in neuropsychological batteries and to be used in routine clinical practice. [ABSTRACT FROM AUTHOR]

Heat transfer in the human eyeball, a complex organ, is significantly influenced by various pathophysiological and external parameters. Particularly, heat transfer critically affects fluid behavior within the eye and ocular drug delivery processes. Overcoming the challenges of experimental analysis, this study introduces a comprehensive three‐dimensional mathematical and computational model to simulate the heat transfer in a realistic geometry. Our work includes an extensive sensitivity analysis to address uncertainties and delineate the impact of different variables on heat distribution in ocular tissues. To manage the model's complexity, we employed a very fast model reduction technique with certified sharp error bounds, ensuring computational efficiency without compromising accuracy. Our results demonstrate remarkable consistency with experimental observations and align closely with existing numerical findings in the literature. Crucially, our findings underscore the significant role of blood flow and environmental conditions, particularly in the eye's internal tissues. Clinically, this model offers a promising tool for examining the temperature‐related effects of various therapeutic interventions on the eye. Such insights are invaluable for optimizing treatment strategies in ophthalmology. [ABSTRACT FROM AUTHOR]

Objective: To develop and validate a questionnaire to evaluate missed nursing care (MNC) in a home care setting. Design: A new instrument was developed and tested performing a preliminary analysis of a multicenter cross‐sectional study in Italy. Reporting was performed according to COnsensus‐based Standards for the selection of health status Measurement INstruments (COSMIN) guidelines. Sample: Eight hundred out of a total of 2549 home care nurses enrolled in AIDOMUS‐IT were considered for the validation of the Missed Nursing Care in Home Care (MNC_HC). Measurements: The MNC_HC instrument was developed by a panel of experts and underwent content and face validation. Exploratory (EFA) and confirmatory factor analyses (CFA) were conducted. Results: EFA revealed a one‐factor solution, explaining 56% of the total variance for MNC_HC. CFA confirmed excellent structural validity, with a one‐factor model showing an exceptional fit (χ2 (27) = 141.39, p <.001, RMSEA = 0.04, SRMR = 0.04, CFI = 0.99, TLI = 0.99, factor loadings > 0.5). MNC_HC also demonstrated high reliability (Cronbach's α = 0.92). The activity with the highest rate of missed care was the documentation of nursing care (77%), while activities related to nursing techniques (e.g., injections, dressings, etc.) were reported to be missed less (33.63%). Conclusions: MNC_HC is a quick‐filling, valid, reliable, and psychometrically sound instrument for measuring MNC in home care useful for future research. [ABSTRACT FROM AUTHOR]

The article reports simple, rapid, and novel enantioselective reversed‐phase high‐performance liquid chromatography (RP‐HPLC) for separation of (−)‐(3R, 4R)‐ormeloxifene hydrochloride (d‐ORM) and (+)‐(3S, 4S)‐ormeloxifene hydrochloride (l‐ORM) (ORM, centchroman) using chiral stationary phase (Chiral‐AGP, Chiracel OJ‐RH, and ChiraDEX HR). The best enantiomeric separation was obtained on the ChiraDEX HR (α = 0.89, Rs = 1.9) column with a gradient mode elution using a combination of ammonium acetate (10 mM, pH 4.0) and methanol as a mobile phase. The flow rate and column oven temperature were 0.7 mL/min and 30°C, respectively. The detection limits (λmax 280 nm) for d‐ORM and l‐ORM were 0.170 and 0.169 µg/mL, whereas quantification limits were 0.516 and 0.512 µg/mL. The method was validated according to the International Council on Harmonization (ICH) regulatory Guidelines Q2 (R1) in terms of its accuracy, precision, sensitivity, linearity, specificity, robustness, and solution stability. The designed analytical method could be extended as a quality control tool for pharmaceutical quality assessments as well as isomeric quantification of ORM in industrial bulk manufacturing. [ABSTRACT FROM AUTHOR]

The present study aimed to develop and validate a questionnaire assessing parents' beliefs about, and attitudes toward, supporting young children's English as a second/foreign language development – Parent English Language Belief and Attitude Questionnaire (PELBA-Q). The PELBA-Q was piloted with 173 parents of kindergarten-aged children and further validated with a sample of 278 parents in Hong Kong. A series of exploratory factor analysis and confirmatory factor analysis was conducted to explore the factor structure and evaluate model fit, which resulted in a 20-item questionnaire with four factors (i.e. Perceived Importance of the Home Environment; Perceived Child's English Language Ability and Self-Efficacy; Normative Beliefs; and Control Beliefs). The convergent and divergent validity of the PELBA-Q were also established by examining the relationship between the PELBA-Q and parents' home practices and family characteristics. The PELBA-Q had satisfactory model fit indices and demonstrated good reliability and validity. The findings showed that the PELBA-Q could potentially be used as a sound assessment tool for measuring parents' beliefs and attitudes on young children's English as a second/foreign language development and could contribute to greater understanding of how parental beliefs and attitudes may influence home practices and children's English language learning outcomes. [ABSTRACT FROM AUTHOR]