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The genus Vibrio includes pathogenic bacteria able to cause disease in humans and aquatic organisms, leading to disease outbreaks and significant economic losses in the fishery industry. Despite much work on Vibrio in several marine organisms, no specific studies have been conducted on Anadara tuberculosa. This is a commercially important bivalve species, known as "piangua hembra," along Colombia's Pacific coast. Therefore, this study aimed to identify and characterize the genomes of Vibrio isolates obtained from A. tuberculosa. Bacterial isolates were obtained from 14 A. tuberculosa specimens collected from two locations along the Colombian Pacific coast, of which 17 strains were identified as Vibrio: V. parahaemolyticus (n = 12), V. alginolyticus (n = 3), V. fluvialis (n = 1), and V. natriegens (n = 1). Whole genome sequence of these isolates was done using Oxford Nanopore Technologies (ONT). The analysis revealed the presence of genes conferring resistance to beta-lactams, tetracyclines, chloramphenicol, and macrolides, indicating potential resistance to these antimicrobial agents. Genes associated with virulence were also found, suggesting the potential pathogenicity of these Vibrio isolates, as well as genes for Type III Secretion Systems (T3SS) and Type VI Secretion Systems (T6SS), which play crucial roles in delivering virulence factors and in interbacterial competition. This study represents the first genomic analysis of bacteria within A. tuberculosa, shedding light on Vibrio genetic factors and contributing to a comprehensive understanding of the pathogenic potential of these Vibrio isolates.

© 2010 American Meteorological Society. This project was accomplished within the collaboration agreement 091153 between UCM and CIEMAT, and it was partially funded by projects CGL2005-06966-C07/CLI and PSE-120000-2008-9 We thank the Navarra Government for providing us with the wind dataset used in this study. We also like to thank the reviewers for their helpful comments., Meteorological data of good quality arc important for understanding both global and regional climates In this respect, great efforts have been made to evaluate temperature- and precipitation-related records This study summarizes the evaluations made to date of the quality of wind speed and direction records acquired at 41 automated weather stations in the northeast of the Iberian Peninsula Observations were acquired from 1992 to 2005 at a temporal resolution of 10 and 30 min A quality assurance system was imposed to select) the records for 1) manipulation errors associated with storage and management of the data. 2) consistency limits to to ensure that observations ale within their natural limits of variation, and 3) temporal consistency to assess abnormally low/high variations in the individual time series In addition. the most important biases of the dataset are analyzed and corrected wherever possible A total of 1 8% wind speed and 3 7% wind direction records was assumed invalid. pointing to specific problems in wind measurement The study not only tiles to contribute to the science with the creation of a wind damsel of unmoved quality. but it also reports on potential errors that could be plc:sent in other wind datasets, Universidad Complutense de Madrid (UCM), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

Copyright 2007 by the American Geophysical Union. This study was financially supported by projects REN2002-04584-C04-01-CLI, REN-2002-04584-C04-04-CLI, CGL2005-06966-C07-04/CLI and CGL2005-06966-C07-05/CLI of the Spanish Ministry of Science and Technology. Jesús Fernández received support from the Department of Education, Universities and Research of the Basque Autonomous Government through grant BFI04.52. J. Sáenz received support by the research groups’ support program, project 9/UPV 00060.310-15343/2003, University of the Basque Country. The gridded precipitation and temperature data were supplied by the Climate Impacts LINK Project (UK Department of the Environment Contract EPG 1/1/16) on behalf of the Climatic Research Unit, University of East Anglia. The boundary conditions were downloaded from the NCEP/NCAR Web server. The National Institutes of Meteorology of Spain and Portugal provided access to daily records of temperature and precipitation at several sites. Other surface and boundary data were provided by the MARS system of the ECMWF. The authors thank the Pennsylvania State University/National Center for Atmospheric Research numerical model home page for making the MM5 model publicly available. Authors made extensive use of the Generic Mapping Tools software [Wessel and Smith, 1991]. GTOPO30 topography data are distributed by the Land Processes Distributed Active Archive Center (LP DAAC), located at the U.S. Geological Survey’s EROS Data Center http://LPDAAC.usgs.gov. We appreciate the comments on the manuscript made by Jimy Dudhia. The comments by three anonymous reviewers have also improved the final version of this manuscript., We present an analysis of the sensitivity to different physical parameterizations of a high-resolution simulation of the MM5 mesoscale model over the Iberian Peninsula. Several (16) 5-year runs of the MM5 model with varying parameterizations of microphysics, cumulus, planetary boundary layer and longwave radiation have been carried out. The results have been extensively compared with observational precipitation and surface temperature data. The parameterization uncertainty has also been compared with that related to the boundary conditions and the varying observational data sets. The annual cycles of precipitation and surface temperature are well reproduced. The summer season presents the largest deviations, with a 5 K cold bias in the southeast and noticeable precipitation errors over mountain areas. The cold bias seems to be related to the surface, probably because of the excessive moisture availability of the five-layer soil scheme used. No parameterization combination was found to perform best in simulating both precipitation and surface temperature in every season and subregion. The Kain-Fritsch cumulus scheme was found to produce unrealistically high summer precipitation. The longwave radiation parameterizations tested were found to have little impact on our target variables. Other factors, such as the choice of boundary conditions, have an impact on the results as large as the selection of parameterizations. The range of variability in the MM5 physics ensemble is of the same order of magnitude as the observational uncertainty, except in summer, when it is larger and probably related to the inaccuracy of the model to reproduce the summer precipitation over the area., Mininsterio de Ciencia y Tecnolgía (MCYT), España, Departamento de Educación, Política Lingüística y Cultura (Gobierno Vasco), Universidad del País Vasco / Euskal Herriko Unibertsitatea (UPV / EHU), Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

© 2013. American Geophysical Union. All Rights Reserved. This investigation was partially supported by projects CGL-2008-05093/CLI and CGL-2011-29677-C02 and was accomplished within the collaboration agreement 09/490 between CIEMAT and NCAR as well as the collaboration agreement 09/153 between CIEMAT and UCM. NCAR is sponsored by the National Science Foundation. We would like to thank the Navarra government and the ECMWF for facilitating the access to its data sets. We also would like to thank the reviewers for their constructive comments which helped to increase the value of the contents of the manuscript., The performance of the Weather Research and Forecasting (WRF) model to reproduce the surface wind circulations over complex terrain is examined. The atmospheric evolution is simulated using two versions of the WRF model during an over 13year period (1992 to 2005) over a complex terrain region located in the northeast of the Iberian Peninsula. A high horizontal resolution of 2km is used to provide an accurate representation of the terrain features. The multiyear evaluation focuses on the analysis of the accuracy displayed by the WRF simulations to reproduce the wind field of the six typical wind patterns (WPs) identified over the area in a previous observational work. Each pattern contains a high number of days which allows one to reach solid conclusions regarding the model performance. The accuracy of the simulations to reproduce the wind field under representative synoptic situations, or pressure patterns (PPs), of the Iberian Peninsula is also inspected in order to diagnose errors as a function of the large-scale situation. The evaluation is accomplished using daily averages in order to inspect the ability of WRF to reproduce the surface flow as a result of the interaction between the synoptic scale and the regional topography. Results indicate that model errors can originate from problems in the initial and lateral boundary conditions, misrepresentations at the synoptic scale, or the realism of the topographic features., Ministerio de Economía y Competitividad (MINECO), Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), España, National Center for Atmospheric Research (NCAR), Universidad Complutense de Madrid (UCM), National Science Foundation (NSF), Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

© European Geophysical Society 2002. Topical Editor J.-P. Duvel thanks I. Durre and J. Coiffier for their help in evaluating this paper., Extremely hot days (EHD) in Madrid have been analysed to determine the synoptic patterns that produce EHDs during the period of 1955-1998. An EHD is defined as a day with maximum temperature higher than 36.5°C, a value which is the threshold for the intense effects on mortatility and it coincides with the 95 percentile of the series. Two different situations have been detected as being responsible for an EHD occurrence, one more dynamical, produced by southern fluxes, and another associated with a stagnation situation over Iberia of a longer duration. Both account for 92% of the total number of days, thus providing an efficient classification framework. A circulation index has been derived to characterise and forecast an EHD occurrence. This paper shows that EHD occur in Madrid during short duration events, and no long heat waves, like those recorded in other cities, are present. Additionally, no clear pattern can be detected in the EHD frequency; the occurrence is tied to changes in the summer location of the Azores high., Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

© 2008 American Meteorological Society. We thank the Sección de Evaluación de Recursos Agrarios del Departamento de Agricultura, Ganadería y Alimentación of the Navarra Government for providing us with the wind dataset used in this study and the ECMWF for the free access to the ERA-40 data. We also thank Drs. M. Montoya and C. Raible for useful discussions, suggestions, and comments during this work, as well as Prof. M. Cornide for providing a first version of the code to calculate the spectral densities. The authors are indebted to the three reviewers for their comments, which helped to improve the quality of the original manuscript considerably. This work was partially funded by Project CGL2005- 06966-C07/CLI. JFGR was supported by a Ramón y Cajal fellowship., Daily wind variability in the Comunidad Foral de Navarra in northern Spain was studied using wind observations at 35 locations to derive subregions with homogeneous temporal variability. Two different methodologies based on principal component analysis were used to regionalize: 1) cluster analysis and 2) the rotation of the selected principal components. Both methodologies produce similar results and lead to regions that are in general agreement with the topographic features of the terrain. The meridional wind variability is similar in all subregions, whereas zonal wind variability is responsible for differences between them. The spectral analysis of wind variability within each subregion reveals a dominant annual cycle and the varying presence of higher-frequency contributions in the subregions. The valley subregions tend to present more variability at high frequencies than do higher-altitude sites. Last, the influence of large-scale dynamics on regional wind variability is explored by studying connections between wind in each subregion and sea level pressure fields. The results of this work contribute to the characterization of wind variability in a complex terrain region and constitute a framework for the validation of mesoscale model wind simulations over the region., Programa Ramón y Cajal (MEC), Ministerio de Educación y Ciencia (MEC), España, Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

© 2003 Royal Meteorological Society. This study is supported by the Spanish Comision Interministerial de Ciencia y Tecnologia under grant CLI98-0649. The Spanish Instituto Nacional de Meteorología provided the data for this study. The authors wish to thank the two anonymous referees for their useful comments, which contributed to improving the quality and presentation of this work., A strong decreasing trend in the Canary Islands' precipitation is detected by studying daily rainfall time series for the second half of the 20th century. An analysis of the extreme events shows that this trend is due mainly to a decrease in the upper percentiles of the precipitation distribution. The results suggest that local factors play a fundamental role on extreme event behaviour., Spanish Comisión Interministerial de Ciencia y Tecnología, Depto. de Física de la Tierra y Astrofísica, Fac. de Ciencias Físicas, TRUE, pub

Purpose of Review: This article aims to review and synthesize the current research evidence regarding the efficacy of telepsychiatry-delivered substance use disorder treatment using a narrative review with a focus on the effects of remote healthcare delivery within the substance abuse treatment space. Recent Findings: The COVID-19 pandemic exerted substantial pressures on all levels of society. Social isolation, loss of employment, stress, physical illness, overburdened health services, unmet medical needs, and rapidly changing pandemic restrictions had particularly severe consequences for people with mental health issues and substance use disorders. Since the start of the pandemic, addiction treatment (and medical treatment overall) using remote health platforms has significantly expanded to different platforms and delivery systems. The USA, in particular, reported transformational policy developments to enable the delivery of telehealth during the COVID-19 pandemic. However, systemic barriers such as a widespread lack of internet access and insufficient patient and provider digital skills remain. Summary: Overall, telepsychiatry is a promising approach for the treatment of substance use disorders, but more randomized controlled trials are needed in the future to assess the evidence base of available interventions.

Long-term nitrogen deposition may not provide sustained stimulation of tree carbon storage, suggest analyses of a tree inventory and growth for the contiguous US between 2000 and 2016, compared to data for the 1980s and 1990s. Changes in nitrogen (N) availability affect the ability for forest ecosystems to store carbon (C). Here we extend an analysis of the growth and survival of 94 tree species and 1.2 million trees, to estimate the incremental effects of N deposition on changes in aboveground C (dC/dN) across the contiguous U.S. (CONUS). We find that although the average effect of N deposition on aboveground C is positive for the CONUS (dC/dN = +9 kg C per kg N), there is wide variation among species and regions. Furthermore, in the Northeastern U.S. where we may compare responses from 2000-2016 with those from the 1980s-90s, we find the recent estimate of dC/dN is weaker than from the 1980s-90s due to species-level changes in responses to N deposition. This suggests that the U.S. forest C-sink varies widely across forests and may be weakening overall, possibly necessitating more aggressive climate policies than originally thought.

Elevated childhood body mass index (BMI), commonly examined as a “once-only” value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations, Background Elevated childhood body mass index (BMI), commonly examined as a "once-only" value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations. Methods Five sex-specific latent class BMI trajectories were generated for 301 927 children (149 325 girls) aged 6-15 years from the Copenhagen School Health Records Register. Information on obesity-related cancers and T2D was obtained from national health registers. Incidence rate ratios (IRR), cumulative incidences, and confidence intervals (CI) were estimated using Poisson regressions. Results Compared with the average childhood BMI trajectory (containing approximately 40% of individuals), the rate of obesity-related cancer (excluding breast cancer) increased with higher childhood BMI trajectories among women. The highest rates occurred in the overweight (IRR = 1.27, 95% CI = 1.17 to 1.38) and obesity (IRR = 1.79, 95% CI = 1.53 to 2.08) BMI trajectories. Similar patterns were observed among men. In contrast, women with the obesity childhood BMI trajectory had the lowest rate of pre- and postmenopausal breast cancer (IRR = 0.59, 95% CI = 0.43 to 0.80, and IRR = 0.41, 95% CI = 0.30 to 0.57, respectively). For all trajectories, the cumulative risk of obesity-related cancer increased with adult-onset T2D. Conclusion Consistent childhood overweight or obesity may increase the rates of adult obesity-related cancer and decrease the rates of breast cancer. Adult-onset T2D conferred additional risk for obesity-related cancer, but the effect did not differ across childhood BMI trajectories.

Aims Low socioeconomic status is associated with all-cause mortality and cardiac risk factors. Furthermore, sudden cardiac death (SCD) is among the leading causes of death in the general population, and an identification of high-risk subgroups is needed. The aim of this study was to investigate the association between income and education level and incidence of SCD and to calculate the impact of modifiable mediating risk factors. Methods and results Participants in the Copenhagen City Heart Study were followed up from 1993 to 2016. Sudden cardiac death was identified using high-quality death certificates, autopsy reports, discharge summaries, and national registry data. Hazard ratios were calculated using Cox proportional hazards regression, and adjusted cumulative incidences were predicted using cause-specific Cox models. Mediation analyses were performed using a marginal structural model approach. During 24 years of follow-up, 10 006 people participated, whereof 5514 died during the study period with 822 SCDs. Compared with long education, persons with elementary school level education had an SCD incidence rate ratio (IRR) of 2.48 [95% confidence interval (CI) 1.86–3.31], and low income was likewise associated with an SCD IRR of 2.34 (95% CI 1.85–2.96) compared with high income. In the association between education and SCD, the combined mediating effect of smoking, physical activity, and body mass index accounted for ∼20% of the risk differences. Conclusion We observed an inverse association between both income and education and the risk of SCD, which was only in part explained by common cardiac risk factors, implying that further research into the competing causes of SCD is needed and stressing the importance of targeted preventive measures., Lay Summary Low socioeconomic status (e.g. education and income) has previously been found associated with an increased risk of death and with different heart diseases. Sudden cardiac death (SCD) is among the leading causes of death in the general population, and predicting who is at high risk is difficult. Finding people or groups at high risk is important to improve prevention. That is why we decided to investigate whether socioeconomic status is also associated with the risk of SCD and to calculate the impact of modifiable lifestyle factors on this risk. We followed similar to 10 000 people from a general population cohort for 24 years and observed 822 sudden cardiac deaths.The lowest income and education groups had more than twice the risk of SCD compared with the high groups.Differences in smoking, physical activity, and body mass index explained similar to 20% of this increase.Aims Low socioeconomic status is associated with all-cause mortality and cardiac risk factors. Furthermore, sudden cardiac death (SCD) is among the leading causes of death in the general population, and an identification of high-risk subgroups is needed. The aim of this study was to investigate the association between income and education level and incidence of SCD and to calculate the impact of modifiable mediating risk factors. Methods and results Participants in the Copenhagen City Heart Study were followed up from 1993 to 2016. Sudden cardiac death was identified using high-quality death certificates, autopsy reports, discharge summaries, and national registry data. Hazard ratios were calculated using Cox proportional hazards regression, and adjusted cumulative incidences were predicted using cause-specific Cox models. Mediation analyses were performed using a marginal structural model approach. During 24 years of follow-up, 10 006 people participated, whereof 5514 died during the study period with 822 SCDs. Compared with long education, persons with elementary school level