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5 results on '"two-stage exchange surgery"'

1. Candida Periprosthetic Joint Infection: Is It Curable?

Author

Laura Escolà-Vergé, Dolors Rodríguez-Pardo, Pablo S. Corona, and Carles Pigrau

Subjects
Candida spp., periprosthetic joint infection, fungus, biofilm, antifungal-loaded cement spacer, two-stage exchange surgery, Therapeutics. Pharmacology, RM1-950
Abstract

Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable.

Published
2021
Full Text
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2. Prosthetic Joint Infection: The Challenges of Prevention, Diagnosis and Treatment and Opportunities for Future Research.

Author

Benito, Natividad, Benito, Natividad, Lora-Tamayo, Jaime, and Murillo, Óscar

Subjects
Epidemiology & medical statistics, Medicine, Candida albicans, Candida spp, Cutibacterium acnes, Staphylococcus aureus, anidulafungin, antibiotic levels, antibiotic prophylaxis, antifungal-loaded cement spacer, arthroplasty infection, biofilm, compliance, dalbavancin, daptomycin, decolonization, diabetic foot infections, drug-drug interaction, eosinophilic pneumonia, epidemiology, extensively drug-resistant, fungus, gram-positive, hematoma, hip arthroplasty, hip hemiarthroplasty, implant removal, infection, intra-articular injection, intraoperative cultures, knee, knee arthroplasty, multidrug-resistant Gram-negative bacteria, osteoarticular infections, outcome, oxazolidinones, periprosthetic joint infection, prolonged antibiotic, prolonged oral treatment, prosthetic joint infection, prosthetic joint infection ambulatory outcome, prosthetic joint infection functional outcome, prosthetic joint infection prevention, prosthetic joint infections, proximal femur fracture, rifampin, risk factors, serum bactericidal titer, sol-gel, suppressive antibiotic treatment, surgical and medical treatment, surgical antimicrobial prophylaxis, surgical site infection, surgical site infection prevention, tedizolid, tolerance, total knee arthroplasty, two-stage exchange surgery
Abstract

Summary: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections.

3. Candida Periprosthetic Joint Infection : Is It Curable?

Author

Escolà-Vergé, Laura, Rodriguez-Pardo, Dolors, Corona, Pablo S., Pigrau, Carles, Universitat Autònoma de Barcelona, Escolà-Vergé, Laura, Rodriguez-Pardo, Dolors, Corona, Pablo S., Pigrau, Carles, and Universitat Autònoma de Barcelona

Abstract

Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable

Published
2021

4. Candida Periprosthetic Joint Infection: Is It Curable?

Author

Dolors Rodríguez-Pardo, P. Corona, Carles Pigrau, Laura Escolà-Vergé, Institut Català de la Salut, [Escolà-Vergé L, Rodríguez-Pardo D, Pigrau C] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. Study Group on Osteoarticular Infections of the Spanish Society of Clinical Microbiology and Infectious Diseases (GEIO-SEIMC), 28003 Madrid, Spain. [Corona PS] Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0003), Instituto de Salud Carlos III, 28029 Madrid, Spain. Study Group on Osteoarticular Infections of the Spanish Society of Clinical Microbiology and Infectious Diseases (GEIO-SEIMC), 28003 Madrid, Spain. Unitat de Cirurgia Sèptica i Reconstructiva, Servei de Cirurgia Ortopèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Subjects
0301 basic medicine, Microbiology (medical), Antifungal, medicine.medical_specialty, medicine.drug_class, Candida spp, 030106 microbiology, Cement spacer, Periprosthetic, Candidiasi - Tractament, Two-stage exchange surgery, RM1-950, antifungal-loaded cement spacer, Biochemistry, Microbiology, biofilm, 03 medical and health sciences, 0302 clinical medicine, Antifungal-loaded cement spacer, two-stage exchange surgery, Antibiotic therapy, Bacterial Infections and Mycoses::Mycoses::Candidiasis [DISEASES], Pròtesis - Complicacions, Periprosthetic joint infection, Bacterial Infections and Mycoses::Infection::Prosthesis-Related Infections [DISEASES], Medicine, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Intensive care medicine, Otros calificadores::/terapia [Otros calificadores], Fungus, 030222 orthopedics, Surgical approach, periprosthetic joint infection, business.industry, Biofilm, fungus, infecciones bacterianas y micosis::infección::infecciones relacionadas con prótesis [ENFERMEDADES], infecciones bacterianas y micosis::micosis::candidiasis [ENFERMEDADES], Other subheadings::/therapy [Other subheadings], Chronic infection, Infectious Diseases, Perspective, Therapeutics. Pharmacology, business
Abstract

Fong; Infecció articular periprotèsica; Cirurgia d'intercanvi en dues etapes Hongo; Infección de la articulación periprotésica; Cirugía de recambio en dos etapas Fungus; Periprosthetic joint infection; Two-stage exchange surgery Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Published
2021

5. Candida Periprosthetic Joint Infection: Is It Curable?

Author

Escolà-Vergé L, Rodríguez-Pardo D, Corona PS, and Pigrau C

Abstract

Candida periprosthetic joint infection (CPJI) is a rare and very difficult to treat infection, and high-quality evidence regarding the best management is scarce. Candida spp. adhere to medical devices and grow forming biofilms, which contribute to the persistence and relapse of this infection. Typically, CPJI presents as a chronic infection in a patient with multiple previous surgeries and long courses of antibiotic therapy. In a retrospective series of cases, the surgical approach with higher rates of success consists of a two-stage exchange surgery, but the best antifungal treatment and duration of antifungal treatment are still unclear, and the efficacy of using an antifungal agent-loaded cement spacer is still controversial. Until more evidence is available, focusing on prevention and identifying patients at risk of CPJI seems more than reasonable.

Published
2021
Full Text
View/download PDF

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