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21,470 results on '"tranexamic acid"'

23. Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage

Author

Indian Council of Medical Research, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Post Graduate Institute of Medical Education and Research, Chandigarh, St. Stephen's Hospital, Delhi, All India Institute of Medical Sciences, New Delhi, Amrita Institute of Medical Sciences & Research Center, Kasturba Medical College Manipal, India, Institute of Neurosciences Kolkata, Bangur Institute of Neurosciences Kolkata, India, Guwahati Neurological Research Center, Guwahati, India, Baptist Christian Hospital, Tezpur, India, National Institute of Mental Health and Neuro Sciences, India, Jawaharlal Institute of Postgraduate Medical Education & Research, Christian Medical College, Vellore, India, CARE Hospitals Hyderabad, India, Lalitha Super Specialities Hospital Guntur, India, Dr. Ramesh Cardiac and Multispeciality Hospital Guntur, India, Government General Hospital Guntur, India, Fortis Escorts Hospital Jaipur, India, Institute of Medical Sciences of the Banaras Hindu University (BHU),India, Atal Institute of Medical Super Specilities, (AIMSS) Chamiana, Shimla, All India Institute of Medical Sciences, Bhubaneswar, KLEs Dr. Prabhakar Kore Hospital & Medical Research Centre Balgaum, India, Guru Gobind Singh Medical College & Hospital, PBM Hospital Bikaner, India, Shree Krishna Hospital Pramukhswami Medical College Anand, India, Apollo Excelcare Hospitals Guwahati, India, Manipal Hospital Bangalore, India, Artemis Hospital Gurgaon, India, Dr. Kamakshi Memorial Hospital Chennai, India, Bharati Vidyapeeth DTU Medical College Pune, India, Aster MIMS Hospital Calicut, India, Holy Spirit Hospital Mumbai, India, Sparsh Superspeciality Hospital Bangalore, India, All India Institute of Medical Sciences, Bilaspur, India, King George's Medical University, Lucknow, India, Assam Medical College, Dibrugarh, India, KG Hospital and Post Graduate Medical Institute Coimbatore, India, Tirunelveli Medical College, Tirunelveli, India, Santokba Durlabhji Memorial Hospital, Jaipur, India, Tezpur Medical College and Hospital, Assam, India, Baby Memorial Hospital Calicut, India, Institute of Human Behaviour and Allied Sciences Delhi, India, The Calcutta Medical Research Institute, Kolkata, India, Fortis Hospital Mulund Mumbai, India, Government Medical College Trivandrum, India, Ruby Hall Clinic, Pune, India, Manipal Hospital Goa, India, and Jeyaraj D Pandian, Principal and Professor, Department of Neurology

Published
2024

45. Does the use of tranexamic acid intraoperatively reduce postoperative blood loss and complications following biportal endoscopic lumbosacral decompression?

Author

Upfill-Brown, Alexander, Olson, Thomas, Adejuyigbe, Babapelumi, Shah, Akash, Sheppard, William, Park, Cheol Wung, Heo, Dong Hwa, and Park, Don Young

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.4 Surgery, Endoscopic spine surgery, biportal spinal endoscopy, lumbosacral decompression, postoperative drain, tranexamic acid
Abstract

BackgroundBiportal endoscopic spine surgery is an effective minimally invasive technique for treating common lumbar pathologies. We aim to evaluate the impact of intraoperative tranexamic acid (TXA) use on postoperative blood loss in biportal endoscopic decompression surgery.MethodsPatients undergoing biportal endoscopic lumbar discectomies and decompressions either by same day surgery or overnight stay at a single institution beginning in October 2021 were prospectively enrolled. This study was non-randomized, non-blinded with the first cohort of consecutive patients receiving 1 g of intravenous TXA intra-operatively before closure and the second cohort of consecutive patients receiving no TXA. Exclusion criteria included any revision surgery, any surgery for the diagnosis of spinal instability, infection, tumor, or trauma, any contraindication for TXA.ResultsEighty-four patients were included in the study, with 45 (54%) receiving TXA and 39 (46%) not receiving TXA. Median follow-up was 168 days [interquartile range (IQR), 85-368 days]. There were no differences in patient or surgical characteristics between cohorts. Estimated blood loss (EBL) was similar (P=0.20), while post-operative drain output was significantly lower in the TXA cohort (P=0.0028). Single level discectomies had significantly less drain output as compared to 2 level unilateral laminotomy, bilateral decompression (ULBD) cases (P0.99 for both). Oswestry disability index (ODI), visual analog scale (VAS) back and VAS leg scores decreased significantly; the absolute decrease in scores did not differ between groups (P=0.71, 0.22, 0.86, respectively).ConclusionsSystemic intraoperative TXA administration is associated with a significant decrease in post-operative blood loss in biportal spinal endoscopy, with no impact on the improvement in patient-reported outcomes (PROs) or rate of post-operative complications. Single level biportal discectomies had significantly less postoperative drainage with TXA and may not need drains postoperatively. Larger, randomized studies are necessary to evaluate the cost-effectiveness of TXA use in biportal spinal endoscopy.

Published
2024

46. WHAT'S DRIVING THE PRESTIGE SKIN CARE BOOM? A potent blend of wellness, Gen Alpha shopping habits, emerging high-efficacy ingredients and professionally inspired beauty are creating significant growth opportunities

Subjects
Tranexamic acid, Toiletries industry, Marketing research, Skin, Skin care products, Business, Pharmaceuticals and cosmetics industries
Abstract

U.S. prestige skin care dollar sales increased 10% in Q1 2024, per Circana, while mass skin care grew just 4% (a). Notably, the number of prestige buyers, their average spend [...]

Published
2024

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