70,229 results on '"tomography, optical coherence"'
Search Results
2. Calcium Reduction by Orbital Atherectomy in Western Europe (CROWN)
- Author
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Wijnand den Dekker, Interventional Cardiologist
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- 2024
3. Efficacy of intravitreal injection of the dexamethasone intravitreal implant Ozurdex® in treatment of patients with refractory diabetic macular edema of different optical coherence tomography patterns
- Author
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WANG Yibo, MENG Xuxia, LIU Penghui, YANG Jing
- Subjects
dexamethasone ,intravitreal injections ,ma-cular edema ,diabetic retinopathy ,tomography, optical coherence ,treatment outcome ,Medicine - Abstract
Objective To investigate the efficacy of intravitreal injection of Ozurdex® in the treatment of refractory diabetic macular edema (DME) with different optical coherence tomography (OCT) patterns. Methods A total of 38 patients (41 eyes) who underwent fundus examination and were diagnosed with refractory DME in Department of Ophthalmology in our hospital from June 2018 to June 2020 were enrolled in this study, and according to the OCT pattern, they were divided into diffuse retinal thickening (DRT) group, cystoid macular edema (CME) group, and serous retinal detachment (SRD) group. Intravitreal injection of Ozurdex® was performed for all diseased eyes as needed, and best corrected visual acuity (BCVA) and OCT measurements were performed before treatment and at 1, 3, and 6 months after treatment. The three groups were compared in terms of BCVA, central foveal thickness (CFT), the integrity of external limiting membrane, ellipsoid zone integrity, and the number of hyperreflective dots (HRDs) before and after treatment. Results All three groups had a significant improvement in BCVA at 1, 3, and 6 months after treatment (Fintra-group=15.334-42.187,P0.05), and at 1, 3, and 6 months after treatment, there was a significant change in the proportion of diseased eyes with different numbers of HRDs (H=23.645-39.117,P
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- 2024
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4. Glycemic Control and Retinal Microvascular Changes in Type 2 Diabetes Mellitus Patients without Clinical Retinopathy
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Kangmin Lee, Ga Hye Lee, Seung Eun Lee, Jee Myung Yang, and Kunho Bae
- Subjects
choroid ,diabetic retinopathy ,glycated hemoglobin ,glycemic control ,tomography, optical coherence ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Background To investigate the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR). Methods This retrospective, observational, cohort study included patients with T2DM without DR. The patients were categorized into intensive control (IC; mean glycosylated hemoglobin [HbA1c] ≤7.0%) and moderate control (MC; mean HbA1c >7.0%) groups. Optical coherence tomography (OCT) and swept-source OCT angiography (OCTA) image parameters were compared between three groups, including healthy controls. Results In total, 259 eyes of 259 participants (88 IC, 81 MC, and 90 controls) were included. The foveal avascular zone area was significantly larger in the MC group than IC and control groups (all P
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- 2024
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5. Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Kidney Transplant Recipients (HARBOR) (HARBOR)
- Author
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Centre Hospitalier Universitaire Dijon and Hôpital Necker-Enfants Malades
- Published
- 2024
6. Structural Description of Skin Biopsies With Dynamic Full-field Optical Coherence Tomography on Suspected Basal Cell Carcinoma Lesions, a Pilot Study (DOCTOBA) (DOCTOBA)
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Thomas Maldiney, Doctor
- Published
- 2024
7. Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab
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Novartis
- Published
- 2023
8. Correlation analysis of retinal characteristics and disease severity in Parkinson's disease
- Author
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TU Min, YANG Shuang-feng, TAN Yu-ling, and WANG Xiao-ming
- Subjects
parkinson disease ,retina ,tomography, optical coherence ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective To investigate the changes of retinal nerve fiber layer (RNFL) thickness and superficial vascular density in patients with Parkinson's disease (PD), and analyze the correlation between the changes and disease severity. Methods Total 43 patients (76 eyes) with PD admitted to the Affiliated Hospital of North Sichuan Medical College from June 2021 to March 2022, and 45 patients (90 eyes) with normal neurological and visual functions from their family members were recruited as the control group. Optical coherence tomography angiography (OCTA) was used to measure RNFL thickness, retinal blood vessel length density and perfusion density, and the area and circumference of foveal avascular zone (FAZ). Disease severity was evaluated by modified Hoehn - Yahr staging, and motor function was evaluated by Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS Ⅲ) in PD group. Pearson and partial correlation analyses were used to investigate the correlation between retinal parameters and PD severity. Results Comparison of OCTA related parameters between the 2 groups: RNFL thickness (t = - 6.424, P = 0.000), central length density (t = - 3.629, P = 0.000), inner ring length density (Z = - 2.846, P = 0.004) and central perfusion density (Z = - 2.703, P = 0.007) in the PD group were lower than those in the control group. Correlation analysis showed that RNFL thickness was negatively correlated with UPDRSⅢ score (r = - 0.625, P = 0.000). Conclusions RNFL thickness may be a potential indicator for early diagnosis and evaluation of the severity of PD.
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- 2024
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9. High diagnostic accuracy of T2FLAIR at 3 T in the detection of optic nerve head edema in acute optic neuritis.
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Shor, Natalia, Lamirel, Cedric, Rebbah, Sana, Vignal, Catherine, Vasseur, Vivien, Savatovsky, Julien, de la Motte, Marine Boudot, Gout, Olivier, Lecler, Augustin, Hage, Rabih, and Deschamps, Romain
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OPTIC nerve , *OPTIC neuritis , *MAGNETIC resonance imaging , *OPTICAL coherence tomography , *FUNDUS oculi , *EDEMA - Abstract
Objectives: Optic nerve head edema (ONHE) detected by fundoscopy is observed in one-third of patients presenting optic neuritis (ON). While ONHE is an important semiological feature, the correlation between ONHE and optic nerve head MRI abnormalities (ONHMA), sometimes called "optic nerve head swelling," remains unknown. Our study aimed to assess the diagnostic accuracy of T2 fluid-attenuated inversion recovery (FLAIR) MRI sequence in detecting ONHE in patients with acute ON. Methods: In the present single-center study, data were extracted from two prospective cohort studies that consecutively included adults with a first episode of acute ON treated between 2015 and 2020. Two experienced readers blinded to study data independently analyzed imaging. A senior neuroradiologist resolved any discrepancies. The primary judgment criterion of ONHMA was assessed as optic nerve head high signal intensity on gadolinium-enhanced T2FLAIR MRI sequence. Its diagnostic accuracy was evaluated with both the gold standard of ONHE on fundus photography (FP) and peripapillary retinal nerve fiber layer thickening on optic coherence tomography (OCT). Results: A total of 102 patients were included, providing 110 affected and 94 unaffected optic nerves. Agreement was high between the different modalities: 92% between MRI and FP (k = 0.77, 95% CI: 0.67–0.88) and 93% between MRI and OCT (k = 0.77, 95% CI: 0.67–0.87). MRI sensitivity was 0.84 (95% CI: 0.70–0.93) and specificity was 0.94 (95% CI: 0.89–0.97) when compared with the FP. Conclusion: Optic nerve head high T2FLAIR signal intensity corresponds indeed to the optic nerve head edema diagnosed by the ophthalmologists. MRI is a sensitive tool for detecting ONHE in patients presenting acute ON. Clinical relevance statement: In patients with optic neuritis the high T2FLAIR (fluid-attenuated inversion recovery) signal intensity of the optic nerve head corresponds indeed to optic nerve head edema, which is a useful feature in optic neuritis etiological evaluation and treatment. Key Points: Optic nerve head edema is a prominent clinical feature of acute optic neuritis and is usually diagnosed during dilated or non-dilated eye fundus examination. Agreement was high between magnetic resonance imaging, fundus photography, and optical coherence tomography. Optic nerve head high T2 fluid attenuation inversion recovery signal intensity is a promising detection tool for optic nerve head edema in patients presenting acute optic neuritis. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Influence of the dilution method on the intraocular duration of C3F8 in vitrectomy for macular hole: a randomized clinical trial.
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da Costa Pinto, Alexandre Paashaus, Camelo Soares, Daniel Tenório, Costa, Marília Rocha, and Cavalcanti Lira, Rodrigo Pessoa
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INTRAVITREAL injections ,SULFUR hexafluoride ,COHERENCE (Optics) ,CLINICAL trials ,INTRAOCULAR pressure - Abstract
Purpose: To compare the injection of small amounts of undiluted C
3 F8 with the traditional gas injection in vitrectomy for macular hole treatment. Methods: This clinical trial included 26 individuals divided into two groups. Group 1 received an intravitreal injection of 0.9-1.0 mL of 100% C3 F8 , and Group 2 received 15-20 mL of 20% C3 F8 . Results: The median intraocular gas duration was 31 days in Group 1 and 34 in Group 2. The median letter gains in corrected distance visual acuity for the 26th postoperative week were 20 letters in Group 1 and 12.5 in Group 2. The median intraocular pressure was normal in both groups. Primary anatomical success was 11/13 in both groups. Conclusions: The use of C3 F8 gas in a small undiluted volume is an alternative that slightly reduces the duration of the gas without negatively affecting the anatomical and visual response. [ABSTRACT FROM AUTHOR]- Published
- 2024
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11. Partial regression of peripapillary myelinated nerve fibers after non-arteritic anterior ischemic optic neuropathy.
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Negrete, Francisco J. Muñoz, Casanova, Victor Aguado, Muñoz Ramón, Pablo Vicente, Mariscal, Marta Gomez, Palomeque, Teresa Salva, and Rebolleda, Gema
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OPTIC nerve diseases ,NERVE fibers ,OPTICAL coherence tomography ,OPTIC disc ,COHERENCE (Optics) - Abstract
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- 2024
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12. Association among retinal health, self-reported depressive symptoms, and demographic, lifestyle and health markers: the META-KLS cohort analysis
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Hannes M.X. Meilicke, Ying Hui, Jing Li, Lejla Colic, Shouling Wu, Shuohua Chen, Shun Zhang, Rui Li, Bin Lv, Hongyang Li, Martin Walter, Zhenchang Wang, Meng Li, Guotong Xie, Zhenjian Yu, and Xiaoliang Liang
- Subjects
Retina ,Tomography, Optical Coherence ,Depression ,Patient Health Questionnaire ,C-Reactive Protein ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: Retinal health indices were suggested to be related to psychopathological symptoms, such as depressive symptoms. However, large-scale studies using optical coherence tomography (OCT) are missing to investigate the associations among them. Methods: In the META-KLS cohort study, 1456 participants (mean age [standard deviation]= 54.6 [11.91] years; n= 680 [47.8%] women) completed the Patient Health Questionnaire (PHQ-9) to measure depressive symptoms and underwent OCT. Poor-quality OCTs and multivariate outliers were excluded, and principal component analysis was performed to obtain retinal health indices separately for macular (n= 930) and optic nerve head (ONH) thicknesses (n= 800). Linear regressions were run controlling for covariates. Exploratory interaction models were run with demographic, lifestyle and health markers. Results: Although there were no direct significant associations between the retinal indices and depressive symptoms (macular: B= −0.05, 95% CI= [-0.15, 0.05], p= 0.32; ONH index: B= -0.02, 95% CI= [-0.11, 0.08], p= 0.71), their associations were moderated by demographic and health factors, e.g., C-reactive protein (CRP) (macular index: B= −0.03, 95% CI= [-0.05, −0.01], p= 0.002; ONH index: B= 0.05, 95% CI= [0.02, 0.08], p= 0.002). Limitations: Study was cross-sectional and there were no functional assessments of vision. Conclusions: In a large cohort, we observed associations between retinal indices and self-reported depressive symptoms depending on demographic and health factors, notably CRP. Following up, the study will investigate the prospective prediction of retinal health on depressive symptoms, especially in persons who may have chronic inflammation.
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- 2024
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13. Histopathological Analysis of Renal Biopsies With Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings for the Diagnosis of Either Acute Kidney Injury or Chronic Kidney Disease in Routine Practices (NEPHROCT) (NEPHROCT)
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Centre Hospitalier Universitaire Dijon and Thomas Maldiney, Principal Investigator
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- 2023
14. Histopathological Analysis of Temporal Artery Biopsy Following Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Patients With Suspected Giant Cell Arteritis (DOCTA) (DOCTA)
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Centre Hospitalier de Mâcon and Thomas Maldiney, Doctor
- Published
- 2023
15. Advances in the application of optical coherence tomography angiography in the diagnosis of common fundus diseases
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LU Huawen, YANG Jun
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tomography, optical coherence ,diagnostic techniques,ophthalmological ,macular degeneration ,retinal vein occlusion ,diabetic retinopathy ,central serous chorioretinopathy ,review ,Medicine - Abstract
Optical coherence tomography angiography (OCTA) is a new noninvasive fundus angiography technique that has been widely used in recent years, and compared with traditional optical coherence tomography, OCTA has a higher resolution and a faster scanning speed. Compared with fundus fluorescein angiography and indocyanine green angiography, OCTA has its own advantages in the diagnosis and treatment of various fundus diseases, such as no need for the injection of contrast agent, a short time for examination, and clear display of the three-dimensional structure of retina and choroid. Although OCTA cannot replace fundus fluorescein angiography in clinical practice at present, it can still be used as an important auxiliary examination in the diagnosis of fundus diseases. Fer this reason, our article reviews the advances in the application of OCTA in the diagnosis of common fundus diseases such as senile macular degeneration, retinal vein occlusion, diabetic retinopathy, and central serous chorioretinopathy.
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- 2024
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16. Does corneal epithelial thickness show the severity of psoriasis? SD-OCT study
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İrfan Botan Güneş, Berna Aksoy, Hakan Öztürk, Fuat Yavrum, and Bediz Özen
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Epithelium, corneal ,Psoriasis ,Tomography, optical coherence ,Dermatology ,RL1-803 - Abstract
Abstract Background Previous studies have generally focused on dry eye test abnormalities and ocular involvements such as uveitis, and blepharitis in psoriasis. Psoriasis area severity ındex (PASI), which is used to assess psoriasis severity, is a time-consuming and complex tool. Objective To evaluate the relationship between disease severity and central corneal epithelial thickness (CCET) in psoriasis. Methods 175 eyes of 175 psoriasis patients and 57 eyes of 57 healthy individuals as a control group was included in this study. Psoriasis patients were divided into three subgroups according to PASI score as < 10 mild, 10‒20 moderate and > 20 severe. CCET was measured by spectral domain-optical coherence tomography (SD-OCT), and mean values were recorded. Mean CCET values were compared between the psoriasis groups and the control group. Additionally, the relationship between PASI score and CCET was examined. Results The mean CCET value was 58.06 ± 3.1 μm in the mild group, 60.10 ± 5.0 μm in the moderate group, 65.75 ± 6.3 μm in the severe group and 56.16 ± 3.1 μm in the control group. It was determined that the mean CCET value was significantly higher in all psoriasis groups compared to the control group (p < 0.001). The mean CCET value was significantly higher in the moderate psoriasis group than in the mild psoriasis group (p = 0.018), and in the severe psoriasis group compared to the moderate psoriasis group (p < 0.001). There was a strong positive correlation between PASI score and CCET (p < 0.001, r = 0.519). Study limitations Cross-sectional design and a relatively small number of participants. Conclusions There is a strong positive correlation between psoriasis severity and CCET. Contactless measurement of CCET by SD-OCT can be an indicator of psoriasis severity.
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- 2023
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17. Measure Airway Compliance by Endobronchial Optical Coherence Tomography
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Xu Hang, Dierctor of Intervetional Pulmonary Center
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- 2023
18. Late-Onset Chronic Corneal Fistula Following Phototherapeutic Keratectomy: A Case Report and Importance of Early Detection.
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Jomar, Deema E., Alshaikh, Lamees, and Al-Swailem, Samar A.
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CORNEA , *FISTULA , *OPTICAL coherence tomography , *INTRAOCULAR pressure , *VISUAL acuity - Abstract
Objective: Unusual clinical course Background: We report a case of late-onset chronic fistula in a decompensated cornea after multiple ocular surgeries and a recent phototherapeutic keratectomy (PTK). Case Report: A 73-year-old woman presented to our service with a past ocular history of bilateral chronic angle closure glaucoma and pseudophakic bullous keratopathy in the left eye. Given a history of long-term uncontrolled glaucoma with advanced disc cupping and poor visual potential, the patient underwent multiple palliative procedures, including, most recently, a PTK. Few years later she presented with a spontaneous late onset of slowly appearing corneal leak on fluorescein staining upon routine clinical examination. Corrected distance visual acuity was hand motion and intraocular pressure (IOP) was 40 mmHg in the affected eye. Serial anterior segment optical coherence tomography (AS-OCT) sections were obtained, which aided in understanding the current presentation and revealed distinctive multilayer corneal changes during the healing process. The patient was successfully managed with cyanoacrylate corneal gluing and ocular hypotensive medications, which halted the corneal leak. Conclusions: We report a case of a rare finding of corneal fistula in an eye with multiple previous ocular surgeries, and provide an explanation of the possible etiopathogenesis. We also highlight the pivotal role of AS-OCT for evaluating such cases and stress the importance of early detection of similar subtle leaks in the setting of a formed anterior chamber, which can often be missed, carrying a risk of infection. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Clinical Efficacy of Near-Infrared Reflectance Imaging and Optical Coherence Tomography in Identifying Ocular Manifestations of Neurofibromatosis Type 1 in Korean Children
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Ji Min Park, Won Hyuk Oh, and Jin Choi
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neurofibromatosis 1 ,tomography, optical coherence ,child ,choroid ,Internal medicine ,RC31-1245 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Purpose The aim of this study was to investigate the clinical efficacy of near-infrared reflectance (NIR) imaging and optical coherence tomography (OCT) in identifying ocular manifestations of neurofibromatosis type 1 (NF1) in Korean children. Methods This retrospective chart review study included five Korean children with NF1 aged under 18 years who had undergone ophthalmic procedures, including slit-lamp examinations, NIR imaging, and OCT scanning. Results Multiple patchy bright lesions were observed on NIR imaging in all eyes (10 eyes in five patients). Further NIR imaging and OCT scans showed that these lesions, confined to the choroid, were choroidal nodules. Lisch nodules, contrastingly, were found in only four of 10 eyes by slit-lamp examinations on the same day as the NIR imaging. One of those four eyes had only one Lisch nodule, which did not meet the NF1 diagnostic criteria. Conclusion NIR imaging enabled the detection of choroidal nodules in Korean children with NF1. Moreover, for Korean children with NF1, choroidal nodules were earlier-detected ocular manifestations relative to Lisch nodules. NIR imaging, along with OCT, is a useful protocol for localizing NF1 nodules in children.
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- 2023
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20. Disability, MRI Lesions and Thickness of Retinal Fibers: Evaluation 15 Years After a First Episode of Demyelination (DB-SEP15)
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- 2022
21. 成人肾病综合征患者黄斑区视网膜厚度与尿蛋白的 相关性研究.
- Author
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郭玉峰, 刘玉梅, 毕秀增, 郭俊麟, 孙莉, 王维秀, and 杨定位
- Abstract
Objective To investigate the correlation between retinal thickness in macular area and urinary protein in adult patients with nephrotic syndrome. Methods A total of 112 inpatients admitted to the internal medicine department were selected and divided into the normal urine protein group (28 cases, 56 eyes), the mildly abnormal urine protein group (30 cases, 58 eyes), the moderately abnormal urine protein group (27 cases, 51 eyes) and the nephrotic syndrome group (27 cases, 53 eyes) according to results of urine protein detection. Optical coherence tomography (OCT) was used to measure the average retinal thickness of the nine divisions in the macula regions, including the central region (Center), temporal side of the inner ring (InT), superior the inner ring (InS), nasal side of the inner ring (InN), inferior the inner ring (InI), temporal side of the outer ring (OutT), superior the outer ring (OutS), inferior the outer ring (OutI) and nasal side of the outer ring (OutN). The correlation ratio E2 was used to analyze the correlation between the mean retinal thickness of different macular regions and the grading of urinary protein in each group. Results The mean retinal thickness of Center, InT, InN and InI in the macular area was higher in the mildly abnormal urine protein group than that in the normal urine protein group. The mean retinal thickness of Center, InT, InS, InN, InI and OutN in the macular area was lower in the moderately abnormal urine protein group than that in the mildly abnormal urine protein group, and the mean retinal thickness of InT, InS, InN and InI in the macular area was higher in the nephrotic syndrome group than that in the moderately abnormal urinary protein group (All P<0.05). The mean retinal thickness of InT, InS, InN and InI in macular area was moderately correlated with the severity of urinary protein group (0.06≤E2 <0.16), while the mean retinal thickness of Center and OutN in macular area was weakly correlated with the severity of urinary protein group (E2 <0.06). Conclusion The mean retinal thickness of InT, InS, InN and InI in macular area may be biomarkers of early lesions of adult nephrotic syndrome. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Longitudinal assessment of dental erosion-abrasion by cross-polarization optical coherence tomography in vitro
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Maria Jacinta Rosario Romero, Sávio José Cardoso Bezerra, Daniel Fried, Frank Lippert, George Joseph Eckert, and Anderson Takeo Hara
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Tooth Wear ,Dental Enamel ,Tomography, Optical Coherence ,Dentistry ,RK1-715 - Abstract
Abstract: This study tested a novel in vitro dental erosion-abrasion model and the performance of cross-polarization optical coherence tomography (CP-OCT) in longitudinally monitoring the simulated lesions. Thirty human enamel specimens were prepared and randomized to receive three dental erosion-abrasion (EA) protocols: severe (s-EA, lemon juice/pH:2.5/4.25%w/v citric acid), moderate (m-EA, grapefruit juice/pH:3.5/1.03%w/v citric acid) and no-EA (water, control). EA challenge was performed by exposing the specimens to acidic solutions 4x/day and to brushing 2x/day with 1:3 fluoridated toothpaste slurry, for 14 days. Enamel thickness measurements were obtained using CP-OCT at baseline (D0), 7 (D7) and 14 days (D14) and micro-computed tomography (micro-CT) at D14. Enamel surface loss was measured with both CP-OCT and optical profilometry at D0, D7 and D14. Data was analyzed with repeated-measures ANOVA and Pearson's correlation (r) (α = 0.05). CP-OCT enamel thickness decreased over time in the s-EA group (D0 >D7 > D14, p < 0.001) and m-EA group (D0 > D14, p = 0.019) but did not change in the no-EA group (p = 0.30). Overall, CP-OCT and micro-CT results at D14 correlated moderately (r = 0.73). CP-OCT surface loss was highest for s-EA (p m-EA>s-EA, p < 0.001). D14 surface loss was higher than D7 for both methods except for the no-EA group with profilometry. CP-OCT and profilometry had moderate overall correlation (r = 0.70). Our results revealed that the currently proposed in vitro dental erosion-abrasion model is valid and could simulate lesions of different severities over time. CP-OCT was a suitable method for monitoring the EA lesions.
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- 2023
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23. Clinical Efficacy of Near-Infrared Reflectance Imaging and Optical Coherence Tomography in Identifying Ocular Manifestations of Neurofibromatosis Type 1 in Korean Children.
- Author
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Park, Ji Min, Oh, Won Hyuk, and Choi, Jin
- Subjects
- *
NEAR infrared reflectance spectroscopy , *OPTICAL coherence tomography , *EYE diseases , *NEUROFIBROMATOSIS 1 , *CHILDREN , *CHOROID - Abstract
Purpose: The aim of this study was to investigate the clinical efficacy of near-infrared reflectance (NIR) imaging and optical coherence tomography (OCT) in identifying ocular manifestations of neurofibromatosis type 1 (NF1) in Korean children. Methods: This retrospective chart review study included five Korean children with NF1 aged under 18 years who had undergone ophthalmic procedures, including slit-lamp examinations, NIR imaging, and OCT scanning. Results: Multiple patchy bright lesions were observed on NIR imaging in all eyes (10 eyes in five patients). Further NIR imaging and OCT scans showed that these lesions, confined to the choroid, were choroidal nodules. Lisch nodules, contrastingly, were found in only four of 10 eyes by slit-lamp examinations on the same day as the NIR imaging. One of those four eyes had only one Lisch nodule, which did not meet the NF1 diagnostic criteria. Conclusion: NIR imaging enabled the detection of choroidal nodules in Korean children with NF1. Moreover, for Korean children with NF1, choroidal nodules were earlier-detected ocular manifestations relative to Lisch nodules. NIR imaging, along with OCT, is a useful protocol for localizing NF1 nodules in children. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
24. Optical Coherence Tomography in a 9-Year-Old Kawasaki Disease Patient with Giant Coronary Artery Aneurysms and Acute Myocardial Infarction.
- Author
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Chih-Wei Ten, Yu-Fa Chang, Wei-Li Hung, and Ming-Ren Chen
- Subjects
- *
MUCOCUTANEOUS lymph node syndrome , *MYOCARDIAL infarction , *OPTICAL coherence tomography , *CORONARY arteries , *BUNDLE-branch block , *THERAPEUTICS - Abstract
Objective: Unusual clinical course Background: Kawasaki disease (KD), a systemic vasculitis, affects children aged <5 years and is the leading acquired cardiovascular disease in developed countries. Although intravenous immunoglobulin is an effective treatment for KD and decreases the rate of cardiovascular complications, some patients still develop coronary sequelae, including coronary aneurysms and myocardial infarction. Case Report: A 9-year-old boy was diagnosed with KD at the age of 6 years. For coronary sequelae of a giant coronary artery aneurysm (CAA) 8.8 mm in diameter, he was prescribed aspirin and warfarin. At 9 years old, he visited the Emergency Department because of acute chest pain. Electrocardiography revealed an incomplete right bundle branch block and ST-T change over right and inferior leads. Also, troponin I was elevated. Coronary angiography found acute thrombotic occlusion of the right CAA. We performed aspiration thrombectomy with intravenous tirofiban. Coronary angiography and optical coherence tomography (OCT) images later found white thrombi, calcification, destruction of media layer, irregular intimal thickening, and uneven intima edge. We prescribed antiplatelet therapy and warfarin, and he was doing well at a 3-year follow-up. Conclusions: OCT is a promising modality that can impact the clinical care in patients with coronary artery disease. This report presents treatment management and OCT images of KD complicated with a giant CAA and acute myocardial infarction. We used aspiration thrombectomy in combination with medical treatments as the initial intervention strategy. Afterward, the OCT images showed vascular wall abnormalities, which were helpful for defining the future risk and decision making of further coronary interventions and medical treatments. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis.
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Pasovski, Katarina Katanić, Rančić, Nemanja, Pasovski, Viktor, Sajić, Marija, Resan, Mirko, and Dinčić, Evica
- Subjects
- *
OPTIC neuritis , *MULTIPLE sclerosis , *DEMYELINATION , *OPTICAL coherence tomography , *PROGNOSIS , *PATHOLOGICAL physiology - Abstract
Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate, retrobulbar neuritis (RBN), is a common presentation of multiple sclerosis (MS). The aim of the study was to determine the diagnostic and prognostic value of structural and functional examination using novel 'swept-source' optical coherence tomography (SS-OCT) and OCT angiography (OCTA) techniques in patients with MS who experienced RBN. Methods. For examining retinal structural and functional changes in both the affected and nonaffected eye of patients with MS, novel techniques, OCT and OCTA, were used. The obtained results were compared with the results of the same examination on the left and right eye of the healthy controls. Results. Using OCT, significant differences in the structural integrity and thickness of retinal layers between the eye in which RBN had been detected and the contralateral, nonaffected eye were found (83.73 ± 18.36 vs. 98.67 ± 11.84; p = 0.013). On the other hand, the functional examination of the macular vascular plexus did not show significant differences between the affected and the nonaffected eye in these patients (41.86 ± 1.52 vs. 42.52 ± 1.40; p = 0.228). Interestingly, comparing the nonaffected eye of patients with RBN and healthy controls, a significant difference in the thickness of the retinal layers between the contralateral eye of the patient and both healthy eyes of healthy subjects was found. OCT examination showed particularly significant thinning of the macular ganglion cell-inner plexiform layer (mGCIPL) (61.07 ± 5.04 vs. 67.53 ± 4.57; p < 0.001). Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable, and repetitive assessment of structural and functional retinal changes as invaluable diagnostic and prognostic tools, paving the way for a better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases. In addition, mGCIPL may be a particularly sensitive and reliable biomarker of pathological changes in MS and perhaps in other neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
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- 2023
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26. Macular morphologic changes following successful retinal detachment repair by scleral buckling surgery
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Petrović Nenad, Todorović Dušan, Srećković Sunčica, Šarenac-Vulović Tatjana, Jovanović Mihailo, and Ranđelović Danijela
- Subjects
eye diseases ,macula lutea ,retinal detachment ,scleral buckling ,tomography, optical coherence ,treatment outcome ,visual acuity ,Medicine (General) ,R5-920 - Abstract
Background/Aim. Spectral domain optical coherence tomography (SDOCT) is very useful for the accurate examination of macular microstructure. The aim of this study was to evaluate macular morphologic changes after successful retinal detachment (RD) surgery by scleral buckling (SB) using SDOCT and assess their impact on vision repair. Methods. SDOCT examination was performed in 1, 6, and 12 months in 27 eyes following SB surgery with the successful anatomical repair of rhegmatogenous RD, which also affected the macular region. The examination was performed in a 6 mm diameter central macular region and included measurements of the central foveal thickness, average total retinal thickness (TRT), and thickness of the inner and outer retinal layer (ORT) separately. The numerical values of parameters for each operated eye were compared with those of the fellow (control) eye of each patient. The condition of the external limiting membrane (ELM) and inner segment (IS) and outer segment (OS) of the photoreceptors was also examined. Results. The mean TRT and ORT in the reattached regions in the operated eyes were significantly thinner than the corresponding regions of the fellow (control) eye, and throughout the follow-up period, the difference was statistically significant. There was a statistically significant difference in TRT (after 1 month, p = 0.021, after 6 months, p = 0.026, after 12 months, p = 0.027) and ORT (after 1 month, p = 0.018, after 6 months, p = 0.019, after 12 months, p = 0.021) between the eyes with a longer preoperative duration of macular detachment (MD) of 2 weeks and eyes with shorter detachment period. Disruptions of the IS and OS of photoreceptors and ELM on SDOCT examination after one month were observed in 37.04% of eyes, after 6 months in 29.6% of eyes, and at the end of the follow-up period in 14.8% of eyes. A statistically significant difference was found in the frequency of disruptions of the IS and OS, and ELM depending on the pre-operative duration of RD (p = 0.007). Conclusion. The overall decrease in the mean retinal thickness after successful anatomical repair of RD is the result of a decrease in the thickness of the outer retinal layers. The alterations of the ELM, IS and OS of photoreceptors observed on the early SDOCT scans are mostly associated with limited vision recovery. The prolonged MD leads to damaging the neurosensory tissue of the retina and especially the photo-receptors, which may explain the limited visual acuity recovery after successful SB repair of RD.
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- 2023
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27. Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis
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Katanić-Pasovski Katarina, Rančić Nemanja, Pasovski Viktor, Sajić Marija, Resan Mirko, and Dinčić Evica
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angiography ,diagnosis ,multiple sclerosis ,optic neuritis ,tomography, optical coherence ,Medicine (General) ,R5-920 - Abstract
Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate, retrobulbar neuritis (RBN), is a common presentation of multiple sclerosis (MS). The aim of the study was to determine the diagnostic and prognostic value of structural and functional examination using novel ‘swept-source’ optical coherence tomography (SS-OCT) and OCT angiography (OCTA) techniques in patients with MS who experienced RBN. Methods. For examining retinal structural and functional changes in both the affected and nonaffected eye of patients with MS, novel techniques, OCT and O CTA, w ere u sed. The obtained results w ere compared with the results of the same examination on the left and right eye of the healthy controls. Results. Using OCT, significant differences in the structural integrity and thickness of retinal layers between the eye in which RBN had been detected and the contralateral, nonaffected eye were found (83.73 ± 18.36 vs. 98.67 ± 11.84; p = 0.013). On the other hand, the functional examination of the macular vascular plexus did not show significant differences between the affected and the nonaffected eye in these patients (41.86 ± 1.52 vs. 42.52 ± 1.40; p = 0.228). Interestingly, comparing the nonaffected eye of patients with RBN and healthy controls, a significant difference in the thickness of the retinal layers between the contralateral eye of the patient and both healthy eyes of healthy subjects was found. OCT examination showed particularly significant thinning of the macular ganglion cell-inner plexiform layer (mGCIPL) (61.07 ± 5.04 vs. 67.53 ± 4.57; p < 0.001). Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable, and repetitive assessment of structural and functional retinal changes as invaluable diagnostic and prognostic tools, paving the way for a better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases. In addition, mGCIPL may be a particularly sensitive and reliable biomarker of pathological changes in MS and perhaps in other neurodegenerative diseases.
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- 2023
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28. 脉络膜毛细血管流空的临床应用研究进展.
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毕萌, 樊芳, and 贾志旸
- Abstract
With the development of optical coherence tomography (optical coherence tomography angiography, OCTA), quantitative study of choriocapillaris (choriocapillaris, CC) has become a novel evaluation method. The occurrence and development of eye diseases, such as retina and choroid are closely related to the morphology and function of choroidal vessels, especially the change of choriocapillaris. The CC flow deficits parameters, such as density, area and number can be obtained after processing and quantitative analysising images of CC layer from OCTA, assess changes in choroid blood capillary perfusion, explore the pathogenesis of related diseases and provide certain help for disease diagnosis and intervention therapy. This paper reviews the clinical application and research progress of choroid capillary flow deficits. [ABSTRACT FROM AUTHOR]
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- 2023
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29. Occult macular dystrophy: brief literature review
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Rafael Godoy, Carolina Tagliari Estacia, Guilherme Sturzeneker, and Aluisio Rosa Gameiro Filho
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Macular dystrophy ,Tomography, optical coherence ,Electrophysiology ,Ophthalmology ,RE1-994 - Abstract
ABSTRACT Occult macular dystrophy is characterized by a slowly progressive bilateral reduction of visual acuity in patients with normal fundus and fluorescein angiography. We describe a case of a 36-year-old male patient diagnosed with this condition, after extensive investigation with multimodal imaging, electrophysiology tests, and systemic screening.
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- 2023
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30. The FAST OCT Study
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Abbott, Pie Medical Imaging, and Joost Daemen, Interventional Cardiologist
- Published
- 2020
31. Plaque rupture and neovascularisation detected with optical coherence tomography in a case of Kounis syndrome
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Shoji Katsuda and Bunji Kaku
- Subjects
Kounis Syndrome ,Cefazolin ,Humans ,Female ,General Medicine ,Acute Coronary Syndrome ,Tomography, Optical Coherence ,Plaque, Atherosclerotic - Abstract
Kounis syndrome is an allergic acute coronary syndrome (ACS) characterised by coronary artery spasm, plaque erosion/rupture or stent thrombosis caused by mast cell and other interacting cell activation. Although intracoronary imaging modalities can detect those ACS mechanisms, Kounis syndrome due to plaque rupture has rarely been reported using intracoronary imaging. We present the case of a woman in her 70s who developed Kounis syndrome as a result of plaque rupture detected with optical coherence tomography (OCT). She had non-ST-segment elevation ACS as a result of anaphylaxis to cefazolin. Coronary angiography revealed severe stenosis in the left anterior descending artery; angiographically undetectable plaque rupture was detected using OCT. OCT also revealed intraplaque neovascularisation, suggesting that the culprit plaque had been vulnerable. OCT can aid in understanding the underlying mechanisms of Kounis syndrome.
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- 2024
32. Insect wing case corneal foreign body: ASOCT-based findings
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Rinky Agarwal, Neeti Rana, Sarita Beri, and Om Prakash
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Insecta ,Eye Foreign Bodies ,Anterior Eye Segment ,Animals ,Humans ,General Medicine ,Tomography, Optical Coherence - Published
- 2024
33. 'Infolded' LASIK flap: an unusual variant of early postoperative flap dislocation
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Raghav Preetam Peraka, Somasheila I Murthy, Vidhyadhar Akkulugari, and Varsha M Rathi
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Male ,Postoperative Complications ,Keratomileusis, Laser In Situ ,Joint Dislocations ,Visual Acuity ,Humans ,General Medicine ,Postoperative Period ,Surgical Flaps ,Tomography, Optical Coherence - Abstract
Flap displacement is a rare but vision-threatening complication of laser-assisted in situ keratomileusis (LASIK). A young male patient underwent uneventful microkeratome-assisted LASIK. One-week postoperatively, flap displacement was noted in his right eye with its lower edge folded inwards, macrostria at the superior edge and the epithelium covering the bare stroma and into the interface. Anterior segment optical coherence tomography (AS-OCT) delineated the morphology of the displaced flap and the extent of epithelial ingrowth. The flap was repositioned by unrolling the fold and all the exposed surfaces were debrided to remove the epithelial ingrowth. Two months later, his corrected distance visual acuity improved to 20/30, and a smooth surface could be achieved. Infolded LASIK flap is a rare complication, which requires timely surgical intervention to achieve successful anatomical and functional outcomes. AS-OCT can be pivotal in determining the extent of infolding as well to delineate the extent of epithelial ingrowth within the interface.
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- 2024
34. Prognostic Impact of Intravascular Imaging-Guided Percutaneous Coronary Intervention in Chronic Total Occlusion.
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David Hong, Sang Min Kim, Sang Yeub Lee, Ki Hong Choi, Young Bin Song, Jong-Young Lee, Seung-Jae Lee, Kyeong Ho Yun, Jae Young Cho, Chan Joon Kim, Hyo-Suk Ahn, Chang-Wook Nam, Hyuck-Jun Yoon, Yong Hwan Park, Wang Soo Lee, Jin-Ok Jeong, Pil Sang Song, Joon-Hyung Doh, Sang-Ho Jo, and Chang-Hwan Yoon
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- *
CHRONIC total occlusion , *PERCUTANEOUS coronary intervention - Published
- 2023
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35. FANTOM ENCORE Sirolimus-eluting Bioresorbable Scaffold for Treatment of De-novo CAD: the ENCORE-I Study
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Horizon 2020 - European Commission, REVA Medical, Inc., and Joost Daemen, Interventional Cardiologist
- Published
- 2020
36. Prospective Clinical Study of Retinal Microvascular Alteration After ICL Implantation
- Published
- 2020
37. Firehawk™ Coronary Stent System in the Treatment of Coronary Chronic Total Occlusion Lesion(s)
- Published
- 2020
38. Comparing six cases of external macular holes and literature review.
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Cenovicz, Murilo Simão, Robaina, Guilherme Gonçalves, de Morais Zanatta, Ana Letícia, and Moreira Neto, Carlos Augusto
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- *
LITERATURE reviews , *OPTICAL coherence tomography , *COHERENCE (Optics) , *MACULAR degeneration , *DIAGNOSTIC imaging , *RADIATION injuries , *DIFFERENTIAL diagnosis - Abstract
The characteristic optical coherence tomography finding in solar maculopathy is a well-defined outer retinal hyporeflective space primarily involving the photoreceptor inner and outer segment layers. This typical optical coherence tomography image may be present in a few other pathologies, which currently constitute their main differential diagnoses. Our study shows the report of 12 eyes of 6 patients treated at the Hospital de Olhos do Paraná, presenting their clinical history and diagnostic images, with the purpose of comparing the findings of the first 3 patients (diagnosed with solar maculopathy) with the last 3 patients, which are also cases of external macular holes. [ABSTRACT FROM AUTHOR]
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- 2023
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39. Optical coherence tomography in neurodegenerative disorders
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Leonardo Provetti CUNHA, Leopoldo Antônio PIRES, Marcelo Maroco CRUZEIRO, Ana Laura Maciel ALMEIDA, Luiza Cunha MARTINS, Pedro Nascimento MARTINS, Nadia SHIGAEFF, and Thiago Cardoso VALE
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Tomography, Optical Coherence ,Alzheimer Disease ,Parkinson Disease ,Multiple Sclerosis ,Neurodegenerative Diseases ,Amyotrophic Lateral Sclerosis ,Retina ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
ABSTRACT Structural imaging of the brain is the most widely used diagnostic tool for investigating neurodegenerative diseases. More advanced structural imaging techniques have been applied to early or prodromic phases, but they are expensive and not widely available. Therefore, it is highly desirable to search for noninvasive, easily accessible, low-cost clinical biomarkers suitable for large-scale population screening, in order to focus on making diagnoses at the earliest stages of the disease. In this scenario, imaging studies focusing on the structures of the retina have increasingly been used for evaluating neurodegenerative diseases. The retina shares embryological, histological, biochemical, microvascular and neurotransmitter similarities with the cerebral cortex, thus making it a uniquely promising biomarker for neurodegenerative diseases. Optical coherence tomography is a modern noninvasive imaging technique that provides high-resolution two-dimensional cross-sectional images and quantitative reproducible three-dimensional volumetric measurements of the optic nerve head and retina. This technology is widely used in ophthalmology practice for diagnosing and following up several eye diseases, such as glaucoma, diabetic retinopathy and age-related macular degeneration. Its clinical impact on neurodegenerative diseases has raised enormous interest over recent years, as several clinical studies have demonstrated that these diseases give rise to reduced thickness of the inner retinal nerve fiber layer, mainly composed of retinal ganglion cells and their axons. In this review, we aimed to address the clinical utility of optical coherence tomography for diagnosing and evaluating different neurodegenerative diseases, to show the potential of this noninvasive and easily accessible method.
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- 2022
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40. Paracentral acute middle maculopathy with occlusive retinal vasculitis in presumed intraocular tuberculosis and hyperhomocysteinemia
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Ramanuj Samanta, Mohit Dogra, Athul Suresh Puthalath, and Gitanjli Sood
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Male ,Retinal Vasculitis ,Macular Degeneration ,Retinal Diseases ,Acute Disease ,Hyperhomocysteinemia ,Humans ,Tuberculosis ,Retinal Vessels ,General Medicine ,Fluorescein Angiography ,Tomography, Optical Coherence - Abstract
A male patient presented with a sudden visual decline in the right eye (OD). Fundus revealed bilateral vasculitis; OD also showed an occluded inferior retinal vein and a wedge-shaped retinal opacification of the inferior macula and nasal retina. Fluorescein angiography revealed occlusive retinal vasculitis, while optical coherence tomography showed paracentral acute middle maculopathy (PAMM) in the OD. A thorough systemic evaluation revealed hyperhomocysteinemia and a positive Mantoux test. A diagnosis of PAMM with occlusive retinal vasculitis in presumed intraocular tuberculosis and hyperhomocysteinemia was made. Retinal vasculitis improved with oral corticosteroid, intravitreal anti-vascular endothelial growth factor and laser photocoagulation. However, the patient declined antitubercular therapy despite recommendations. This unique report indicates that PAMM may complicate tubercular retinal vasculitis, especially in the presence of systemic hypercoagulable states.
- Published
- 2024
41. Correlation between intraoperative and postoperative vaulting of the EVO implantable Collamer lens: a retrospective study of real-time observations of vaulting using the RESCAN 700 system
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Nian Guan, Xiao-Nong Zhang, and Wan-Jun Zhang
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Lenses, intraocular ,lens implantation, intraocular ,Tomography, optical coherence ,Refractive surgery ,Post-operative vault ,Ophthalmology ,RE1-994 - Abstract
Abstract Background Implantable Collamer lens (ICL) vaulting is one of the most important parameters for the safety, aqueous humor circulation, and lens transparency after ICL implantation. This study aimed to investigate the factors associated with the actual vaulting after refractive EVO-ICL surgery. Methods This retrospective study included patients who underwent EVO-ICL surgery at a tertiary eye hospital between October and December 2019. A RESCAN 700 was used for the intraoperative and CIRRUS HD-OCT was used for postoperative observation of vaulting. Subjective and objective refractions, anterior ocular segment, corneal morphology, intraocular pressure (IOP), anterior chamber volume (ACV), crystalline lens rise (CLR), white-to-white distance (WTW), anterior chamber depth (ACD), axial length, corneal endothelial cell density (ECD), and fundoscopy were examined. A multivariable analysis was performed to determine the factors independently associated with 1-month postoperative vaulting. Results Fifty-one patients (102 eyes) were included. Compared with the eyes with normal vaulting, those with high vaulting had higher preoperative diopter values (P = 0.039), lower preoperative corrected visual acuity (P = 0.006), lower preoperative IOP (P = 0.029), higher preoperative ACD (P = 0.004), lower preoperative CLR (P = 0.046), higher ICL spherical equivalent (P = 0.030), higher intraoperative vaulting (P
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- 2022
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42. Analysis of structural and vascular changes of the optic nerve head and macula in different stages of primary open angle glaucoma
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Petrović Maja, Resan Mirko, Stanković-Babić Gordana, Šarenac-Vulović Tatjana, Radenković Marija, Veselinović Aleksandar, Trenkić Marija, and Cvetanović Marija
- Subjects
angiography ,disease progression ,glaucoma, open-angle ,macula lutea ,optic disc ,tomography, optical coherence ,Medicine (General) ,R5-920 - Abstract
Background/Aim. It is possible that patients with open-angle glaucoma be asymptomatic in the early stage of the disease. The aim of this study was to determine the structural and vascular changes of the optic disc (OD) and macula in healthy and primary open-angle glaucoma (POAG) eyes, detected by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) as well as the correlation of the OCT and OCTA measurements and their association with the presence of POAG. Methods. A total of 196 eyes were included and classified into four groups, out of them 48 were healthy eyes, 51 eyes were with mild POAG, 50 eyes with moderate POAG, and 47 eyes with advanced glaucoma. All subjects underwent standard ophthalmic examination. OCT measured the mean, superior and inferior retinal nerve fiber layer (RNFL) thickness and macular ganglion cell complex (GCC). OCTA evaluated the vessel capillary density (VCD) in OD, foveal avascular zone (FAZ) and macular vessel density (VD) in the superficial (SL) and deep (DL) retinal vascular plexus. Results. Patient characteristics were similar except for decreased visual acuity, thinner corneas, higher intraocular pressure and higher cup/disc ratio in POAG patients. OCT results showed that RNFL and GCC thickness gradually de-creased according to POAG severity. Within the assessment conducted by OCTA, VCD’s value in OD also diminished with the progression of POAG, having the lowest value in patients with advanced glaucoma. The same pattern was observed in vessel density around FAZ and VD values. Comparing the structural and vascular changes, a significant positive correlation was found between RNFL thickness and VCD inside OD, and GCC and VD SL in the macular zone. Conclusion. OCT and OCTA allow of a noninvasive quantification of the structural and vascular changes in OD and the macular zone and accurately distinguish between healthy eyes and eyes with POAG, showing an association with the presence and progression of glaucoma.
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- 2022
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43. SD-OCT assessment and visual field changes 1 year or more after a single episode of unilateral acute primary angle closure
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Rafael Vidal Merola, Sebastião Cronemberger, Érica de Abreu Borges, and Jamily Batista Prates
- Subjects
Tomography, optical coherence ,Visual fields ,Glaucoma, angle-closure ,Optic disc ,Macula lutea ,Ophthalmology ,RE1-994 - Abstract
ABSTRACT Objective: To evaluate structural and visual field (VF) changes after ≥1 year of a single acute primary angle closure (APAC) attack using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry (SAP). Methods: Patients with a single unilateral APAC crisis at least 1 year ago were included consecutively from 2013 to 2016. Contralateral eye was used as control. All patients underwent ophthalmic examination, RNFL imaging by SD-OCT, and SAP using Octopus 1-2-3. Results: 54 eyes (27 patients) were enrolled. Male-to-female ratio was 1:2. Mean time for the SD-OCT and SAP assessment after the crisis was 5.0±5.1 (1.0–23.5) years, and IOP was 52.5±9.8 mmHg. In APAC eyes, the thicknesses of all quadrants of peripapillary RNFL (36.3%; P
- Published
- 2022
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44. Honeycomb epithelial oedema due to ripasudil: clinical, optical coherence tomography and histopathological correlation
- Author
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Neha Jain, Archana Singh, Dilip K Mishra, and Somasheila I Murthy
- Subjects
Male ,Sulfonamides ,Endothelium, Corneal ,Edema ,Humans ,General Medicine ,Middle Aged ,Isoquinolines ,Descemet Stripping Endothelial Keratoplasty ,Tomography, Optical Coherence ,Corneal Diseases - Abstract
A male in his 50s, who had undergone Descemet’s stripping automated endothelial keratoplasty (DSAEK) for corneal oedema following irido-corneal-endothelial syndrome and glaucoma drainage device surgery for secondary glaucoma presented with gradual decreased vision. The patient was on ripasudil 0.4% for the past 4 months prior to the presentation. Honeycomb epithelial oedema was seen with vesicles and intraepithelial microcyst formation which were also noted on anterior segment optical coherence tomography (OCT) and histopathology, that co-related with the slit-lamp findings. The patient underwent repeat DSAEK and had a good outcome. While the clinical features and OCT findings have been reported earlier, the histopathological features have not been reported.
- Published
- 2024
45. Mimickers of punctate inner retinal toxoplasmosis on optical coherence tomography
- Author
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Miloni Suketu Shah, Atish Kumar Pradhan, Ashish Khalsa, and Anup Kelgaonkar
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Humans ,General Medicine ,Toxoplasmosis, Ocular ,Retina ,Tomography, Optical Coherence - Published
- 2024
46. Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery.
- Author
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Faizi HS, Nasiri MI, Wu Y, Mishra D, Donnelly RF, Minhas MU, Vora LK, and Singh Thakur RR
- Subjects
- Animals, Swine, Solubility, Suspensions, Sclera metabolism, Humans, Retinal Pigment Epithelium drug effects, Nanoparticles administration & dosage, Cell Survival drug effects, Cell Line, Administration, Ophthalmic, Microinjections methods, Drug Stability, Tomography, Optical Coherence, Deferasirox administration & dosage, Deferasirox pharmacokinetics, Needles, Drug Delivery Systems, Iron Chelating Agents administration & dosage
- Abstract
Deferasirox (DFS) is an oral iron chelator that is employed in retinal ailments as a neuroprotectant against retinal injury and thus has utility in treating disorders such as excitoneurotoxicity and age-related macular degeneration (AMD). However, the conventional oral route of administration can present several disadvantages, e.g., the need for more frequent dosing and the first-pass effect. Microneedles (MNs) are minimally invasive systems that can be employed for intrascleral drug delivery without pain and can advantageously replace intravitreal injections therapy (IVT) as well as conventional oral routes of delivery for DFS. In this study, DFS was formulated into a nanosuspension (NS) through wet media milling employing PVA as a stabilizer, which was successfully loaded into polymeric dissolving MNs. DFS exhibited a 4-fold increase in solubility in DFS-NS compared to that of pure DFS. Moreover, the DFS-NSs exhibited excellent short-term stability and enhanced thermal stability, as confirmed through thermogravimetric analysis (TGA) studies. The mechanical characterization of the DFS-NS loaded ocular microneedles (DFS-NS-OcMNs), revealed that the system was sufficiently strong for effective scleral penetration. Optical coherence tomography (OCT) images confirmed the insertion of 81.23 ± 7.35 % of the total height of the MN arrays into full-thickness porcine sclera. Scleral deposition studies revealed 64 % drug deposition after just 5 min of insertion from DFS-NS-loaded ocular microneedles (OcMNs), which was almost 5 times greater than the deposition from pure DFS-OcMNs. Furthermore, both DFS and DFS-NS-OcMN exhibited remarkable cell viability when evaluated on human retinal pigment (ARPE) cells, suggesting their safety and appropriateness for use in the human eye. Therefore, loading DFS-NS into novel MN devices is a promising technique for effectively delivering DFS to the posterior segment of the eye in a minimally invasive manner., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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47. Exploring the protective effects of Qiju Granule in a rat model of dry age-related macular degeneration.
- Author
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Chen Q, Zhang J, Liu X, Xu K, Guo H, Li Y, Liang J, Li Y, and Liang L
- Subjects
- Animals, Male, Rats, Fibroblast Growth Factor 2 metabolism, Brain-Derived Neurotrophic Factor metabolism, Iodates, Glial Fibrillary Acidic Protein metabolism, Glial Fibrillary Acidic Protein genetics, Ciliary Neurotrophic Factor, Disease Models, Animal, Macular Degeneration prevention & control, Macular Degeneration metabolism, Macular Degeneration pathology, Macular Degeneration drug therapy, Drugs, Chinese Herbal pharmacology, Electroretinography, Retina drug effects, Retina metabolism, Retina pathology, Tomography, Optical Coherence, Rats, Sprague-Dawley
- Abstract
Aim: The aim of this study was to evaluate the potential protective effect of Qiju Granule in a rat model of age-related macular degeneration (AMD) and investigate the underlying mechanisms involved., Methods: Rats were injected intravenously with 40 mg/kg of sodium iodate (SI) to induce a dry AMD model. The rats in the treatment group received three different doses of Qiju Granule once a day via gavage, while the rats in the control group were given an equal volume of physiological saline. On day 14 and day 28 following the intervention, various methods were employed to evaluate retinal function and structure, including electroretinography (ERG), optical coherence tomography (OCT), and histological examination. The expression of glial fibrillary acidic protein (GFAP), basic fibroblast growth factor (bFGF), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF) was assessed via immunofluorescence. Beyond immunofluorescence, the mRNA levels of bFGF, BDNF, and CNTF were quantitatively determined using real-time polymerase chain reaction (qRT-PCR)., Results: Rats treated with Qiju Granule exhibited significant improvements in both retinal function and structure compared to the model group. The most noteworthy effects were observed at a high dose of Qiju Granule. Furthermore, the expression levels of bFGF, BDNF, and CNTF were significantly unregulated in the treated groups compared to the model group., Conclusions: Qiju Granule demonstrated a protective effect on the retina in the SI-induced rat model of AMD. The protective mechanism may be attributed to the upregulation of retinal neurotrophic factors expression., Competing Interests: Declaration of competing interest The authors declare that they have no competing interests related to this study. There are no financial or personal relationships with other people or organizations that could influence the conduct or interpretation of the research., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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48. Clinical macular edema following uneventful cataract surgery in eyes without pre-existing fundus diseases: risk factors and treatment prognosis.
- Author
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Lin Y, Xie B, Ke S, Ye W, Huang D, Chen W, and Huang Z
- Subjects
- Humans, Male, Retrospective Studies, Female, Risk Factors, Aged, Prognosis, Case-Control Studies, Middle Aged, Postoperative Complications, Tomography, Optical Coherence, Fundus Oculi, Follow-Up Studies, Pseudophakia physiopathology, Pseudophakia complications, Aged, 80 and over, Macular Edema etiology, Macular Edema diagnosis, Visual Acuity physiology, Phacoemulsification adverse effects
- Abstract
Background: To investigate the risk factors and prognosis of clinical pseudophakic cystoid macular edema (PCME) after uneventful phacoemulsification surgery in patients without pre-existing fundus diseases., Methods: This was a retrospective case-control study. Medical records between August 2020 and August 2023 were reviewed for patients who had no previous fundus diseases and developed clinical PCME. A control group was randomly chosen and the risk factors for PCME was analyzed by binary logistic regression. Structure and visual prognosis of the PCME cohort were observed and compared among subgroups undergoing different treatment measures., Results: Forty-seven eyes of 47 patients with PCME were included. The development of PCME was associated with higher systolic blood pressure (OR, 1.048; 95%CI 1.002, 1.097; P = .042), no posterior vitreous detachment (OR, 0.215; 95%CI: 0.553, 0.887; P = .032) and shorter axial lengths (OR, 0.401; 95%CI 0.161, 0.997; P = .049) compared to controls. During a mean follow-up of 8.26 months, 36 eyes (76.6%) showed visual improvement with decreased macular thickness. Different treatment modalities, including observation, topical NSAIDs, and intervention therapy, have no significant differences on the visual prognosis (P = 1.000). However, the intervention group had a shorter recovery time compared to the observation group (28.6 vs. 45.9 days, P = .037)., Conclusion: PCME remains an encountered morbidity in patients without pre-existing fundus diseases. Shorter axial lengths, absence of posterior vitreous detachment, and higher systolic blood pressure are risk factors of PCME. Active intervention failed to improve the prognosis of PCME but could shorten the recovery time., (© 2024. The Author(s).)
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- 2024
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49. Ibrutinib-Related Uveitis in Non-Hodgkin Lymphoma Patients: A Case Report and Literature Review.
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Mendez R, Pineda-Sierra JS, Romero-Santos S, Cifuentes-González C, Bonaccorso S, Couto C, Schlaen A, Mejía-Salgado G, and de-la-Torre A
- Subjects
- Humans, Female, Middle Aged, Tomography, Optical Coherence, Visual Acuity, Protein Kinase Inhibitors adverse effects, Uveitis chemically induced, Uveitis diagnosis, Uveitis drug therapy, Lymphoma, Non-Hodgkin drug therapy, Waldenstrom Macroglobulinemia drug therapy, Waldenstrom Macroglobulinemia diagnosis, Pyrimidines adverse effects, Pyrimidines therapeutic use, Macular Edema chemically induced, Macular Edema diagnosis, Macular Edema drug therapy, Fluorescein Angiography, Pyrazoles adverse effects, Pyrazoles therapeutic use, Central Nervous System Neoplasms drug therapy, Central Nervous System Neoplasms diagnosis, Adenine analogs & derivatives, Adenine adverse effects, Piperidines adverse effects
- Abstract
Purpose: To report two cases of ibrutinib-related uveitis and review the literature to date., Methods: We report two cases of ibrutinib-related uveitis using CARE guidelines and review the cases reported in the literature., Results: Case 1) A 55-year-old female with recurrent primary central nervous system lymphoma presented with bilateral decreased visual acuity, photophobia, and floaters that started one month after initiating oral treatment with ibrutinib. Chronic non-granulomatous bilateral anterior-intermediate uveitis with macular edema was identified. Secondary causes were ruled out, and a presumptive diagnosis of ibrutinib-related uveitis was made. Case 2) A 57-year-old female with Waldenström macroglobulinemia who was treated with ibrutinib for two years presented with bilateral blurred vision, photophobia, red eyes, and floaters. A diagnosis of non-granulomatous, noninfectious panuveitis with bilateral cystoid macular edema was made. Secondary causes were ruled out, and ibrutinib toxicity was the most likely cause., Conclusion: Ibrutinib-related uveitis is a novel and under-diagnosed clinical entity. The most frequent clinical presentation in the literature is bilateral, non-granulomatous, anterior, and intermediate uveitis. Macular edema is a frequent complication. Uveitis usually requires topical treatment and the suspension of ibrutinib. Switching to second-generation Bruton tyrosine kinase inhibitors is proposed as a potential therapeutic alternative.
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- 2024
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50. Decreased vision due to scarring after phototherapeutic keratectomy.
- Author
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Nuijts RMMA, Ollivier RCI, Schlereth S, Cursiefen C, Busin M, Yu AC, Alió J, Borderie V, Shetty R, Nagaraja H, and Sethu S
- Subjects
- Humans, Male, Adult, Cicatrix physiopathology, Cicatrix etiology, COVID-19 complications, Postoperative Complications, SARS-CoV-2, Lasers, Excimer therapeutic use, Tomography, Optical Coherence, Corneal Topography, Corneal Dystrophies, Hereditary physiopathology, Corneal Dystrophies, Hereditary surgery, Corneal Dystrophies, Hereditary diagnosis, Photorefractive Keratectomy methods, Visual Acuity physiology
- Abstract
In May 2023, a 36-year-old carpenter complained of a sudden decrease in visual acuity in both eyes after his fourth COVID-19 vaccination. He underwent extensive evaluation by ophthalmological, neurological, and internal medicine specialists elsewhere, which was unremarkable, except for a computed tomography scan of his brain showing minor occipital calcifications. In 2021, he had been diagnosed with anterior basement membrane dystrophy and treated with phototherapeutic keratectomy (PTK) of the left eye, leading to significant postoperative haze. On referral in July 2023, slitlamp examination showed significant anterior basement membrane dystrophy in the right eye, whereas the left eye had an extensive central scar in the anterior stroma, measuring up to 6 mm in width and 140 µm in depth (Figures 1-3JOURNAL/jcrs/04.03/02158034-202410000-00017/figure1/v/2024-09-18T130724Z/r/image-tiffJOURNAL/jcrs/04.03/02158034-202410000-00017/figure2/v/2024-09-18T130724Z/r/image-tiffJOURNAL/jcrs/04.03/02158034-202410000-00017/figure3/v/2024-09-18T130724Z/r/image-tiff). His corrected distance visual acuity was 20/80 in his right eye and 20/200 in his left eye, with a manifest refraction of -0.50 -3.75 × 170 and +0.00 -4.75 × 180, respectively. Corneal Scheimpflug topography showed regular corneal astigmatism of 3.3 diopters (D) and 5.5 D in the right and left eyes, respectively, with a corneal thickness of 550 and 566 µm (Figure 4JOURNAL/jcrs/04.03/02158034-202410000-00017/figure4/v/2024-09-18T130724Z/r/image-tiff). The Schirmer tear test was 20-20 mm. Fundoscopy, electrophysiological testing, and retinal optical coherence tomography (OCT) showed no abnormalities. The patient mentioned he had Crohn disease, managed with ustekinumab (a monoclonal antibody inhibitor of cytokines interleukin [IL]-12 and IL-23), but he had discontinued it because of the apparent remission of the disease. Attempts to improve visual acuity involved a soft bandage contact lens in the right eye, which was discontinued after 2 days because of the occurrence of a small corneal infiltrate that healed with a short course of topical antibiotics. Unfortunately, because of his vision, he cannot perform his tasks as a carpenter anymore. Which is your recommended treatment for both eyes?, (Copyright © 2024 Published by Wolters Kluwer on behalf of ASCRS and ESCRS.)
- Published
- 2024
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