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The immune system is the body’s defense against pathogens, which are complex living organisms found in many parts in the body including organs, tissues, cells, molecules, and proteins. When the immune system works properly, it can recognize and kill the abnormal cells and the infected cells. Otherwise, it can attack the body’s healthy cells even if there is no invader. Many researchers have developed immunotherapy (or cancer vaccines) and have used chemotherapy for cancer treatment that can kill fast-growing cancer cells or at least slow down tumor growth. However, chemotherapy drugs travel throughout the body and tend to kill both healthy cells and cancer cells. In this study, we consider the fact that chemotherapy can kill tumor cells and that the loss of the immune cells may at the same time stir up cancer growth. We present a dynamic time-delay tumor-immune model with the effects of chemotherapy drugs and autoimmune disease. The modeling results can be used to determine the progression of tumor cells in the human body with the effect of chemotherapy, autoimmune diseases, and time delays based on partial differential equations. It can also be used to predict when the tumor viruses’ free state can be reached as time progresses, as well as the state of the body’s healthy cells as time progresses. We also present a few numerical cases that illustrate that the model can be used to monitor the effects of chemotherapy drug treatment and the growth rate of tumor virus-infected cells and the autoimmune disease.

The immune system is a complex interconnected network consisting of many parts including organs, tissues, cells, molecules and proteins that work together to protect the body from illness when germs enter the body. An autoimmune disease is a disease in which the body’s immune system attacks healthy cells. It is known that when the immune system is working properly, it can clearly recognize and kill the abnormal cells and virus-infected cells. But when it doesn’t work properly, the human body will not be able to recognize the virus-infected cells and, therefore, it can attack the body’s healthy cells when there is no invader or does not stop an attack after the invader has been killed, resulting in autoimmune disease.; This paper presents a mathematical modeling of the virus-infected development in the body’s immune system considering the multiple time-delay interactions between the immune cells and virus-infected cells with autoimmune disease. The proposed model aims to determine the dynamic progression of virus-infected cell growth in the immune system. The patterns of how the virus-infected cells spread and the development of the body’s immune cells with respect to time delays will be derived in the form of a system of delay partial differential equations. The model can be used to determine whether the virus-infected free state can be reached or not as time progresses. It also can be used to predict the number of the body’s immune cells at any given time. Several numerical examples are discussed to illustrate the proposed model. The model can provide a real understanding of the transmission dynamics and other significant factors of the virus-infected disease and the body’s immune system subject to the time delay, including approaches to reduce the growth rate of virus-infected cell and the autoimmune disease as well as to enhance the immune effector cells.

The immune system is the body's defense against pathogens, which are complex living organisms found in many parts in the body including organs, tissues, cells, molecules, and proteins. When the immune system works properly, it can recognize and kill the abnormal cells and the infected cells. Otherwise, it can attack the body's healthy cells even if there is no invader. Many researchers have developed immunotherapy (or cancer vaccines) and have used chemotherapy for cancer treatment that can kill fast-growing cancer cells or at least slow down tumor growth. However, chemotherapy drugs travel throughout the body and tend to kill both healthy cells and cancer cells. In this study, we consider the fact that chemotherapy can kill tumor cells and that the loss of the immune cells may at the same time stir up cancer growth. We present a dynamic time-delay tumor-immune model with the effects of chemotherapy drugs and autoimmune disease. The modeling results can be used to determine the progression of tumor cells in the human body with the effect of chemotherapy, autoimmune diseases, and time delays based on partial differential equations. It can also be used to predict when the tumor viruses' free state can be reached as time progresses, as well as the state of the body's healthy cells as time progresses. We also present a few numerical cases that illustrate that the model can be used to monitor the effects of chemotherapy drug treatment and the growth rate of tumor virus-infected cells and the autoimmune disease. [ABSTRACT FROM AUTHOR]

The immune system is a complex interconnected network consisting of many parts including organs, tissues, cells, molecules and proteins that work together to protect the body from illness when germs enter the body. An autoimmune disease is a disease in which the body's immune system attacks healthy cells. It is known that when the immune system is working properly, it can clearly recognize and kill the abnormal cells and virus-infected cells. But when it doesn't work properly, the human body will not be able to recognize the virus-infected cells and, therefore, it can attack the body's healthy cells when there is no invader or does not stop an attack after the invader has been killed, resulting in autoimmune disease.; This paper presents a mathematical modeling of the virus-infected development in the body's immune system considering the multiple time-delay interactions between the immune cells and virus-infected cells with autoimmune disease. The proposed model aims to determine the dynamic progression of virus-infected cell growth in the immune system. The patterns of how the virus-infected cells spread and the development of the body's immune cells with respect to time delays will be derived in the form of a system of delay partial differential equations. The model can be used to determine whether the virus-infected free state can be reached or not as time progresses. It also can be used to predict the number of the body's immune cells at any given time. Several numerical examples are discussed to illustrate the proposed model. The model can provide a real understanding of the transmission dynamics and other significant factors of the virus-infected disease and the body's immune system subject to the time delay, including approaches to reduce the growth rate of virus-infected cell and the autoimmune disease as well as to enhance the immune effector cells. [ABSTRACT FROM AUTHOR]