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Copyright of Annales Françaises de Médecine d'Urgence is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Résumé Les tachycardies supra-ventriculaires et leur traitement ont été peu étudiées chez les patients critiques. But de l’étude Évaluer l’efficacité et l’innocuité de la cardioversion pour tachycardie supra-ventriculaire en réanimation. Patients et méthode Inclusion prospective de tous les patients qui ont présenté des tachyarythmies supra-ventriculaire incluant la fibrillation auriculaire, prolongée ≥ 30 secondes dans une réanimation médico-chirurgicales, à l’exception du postopératoire de chirurgie cardiaque. Les médicaments anti-arythmiques et/ou les chocs électriques ont été administrés de façon libérale. Résultats Au cours de la période d’étude de 15 mois, 108/846 (12,8 %) patients ont présenté des tachycardies supra-ventriculaires. Les médicaments anti-arythmiques ont été administrés chez 78 patients (72 %) ; pour la plupart de l’amiodarone (92 %), et/ou du magnésium (23 %), ce qui a entraîné un taux de conversion en rythme sinusal global de 68 %. Le choc électrique externe a été utilisé chez 26 patients (24 %), (médicaments anti-arythmiques reçus préalablement chez 24 patients) avec un taux succès immédiat de 80,8 %. Conclusion Le choc électrique externe a été associé à une conversion soutenue en rythme sinusal à 80,8 %, chez des patients de réanimation avec tachycardie supra-ventriculaire, alors que la plupart d’entre eux avait déjà reçu des médicaments anti-arythmiques. Supra-ventricular tachyarrhythmia and its treatment have been poorly investigated in ICU patients. Aims To evaluate efficacy and safety of cardioversion for supra-ventricular tachyarrhythmia in the intensive care unit (ICU). Patients and methods Prospective inclusion of all patients who presented supra-ventricular tachyarrhythmias lasting ≥ 30 seconds in a single medico-surgical ICU, except cardiac surgery. Anti-arrhythmic drugs and/or direct-current cardioversion were administered on a liberal basis. Results During the 15-month study period, 108/846 patients (12.8%) experienced supra-ventricular tachyarrhythmias. Anti-arrhythmic drugs were administered in 78 patients (72%); mostly amiodarone (92%), and/or magnesium (23%), resulting in an overall conversion rate of 68%. Direct-current cardioversion was used in 26 patients (24%), (24 patients received drug enhancement by anti-arrhythmic drugs) with an immediate 80.8%-success rate. Conclusion Direct-current cardioversion was associated with sustained conversion to sinus rhythm in 80.8% of ICU patients with supra-ventricular tachyarrhythmias, although most of them had already received drug enhancement. [ABSTRACT FROM AUTHOR]

Serotonin (5-hydroxytryptamine; 5-HT) inhibits the rat cardioaccelerator sympathetic outflow by 5-HT1B/1D/5 receptors. Because chronic blockade of sympatho-excitatory 5-HT2 receptors is beneficial in several cardiovascular pathologies, this study investigated whether sarpogrelate (a 5-HT2 receptor antagonist) alters the pharmacological profile of the above sympatho-inhibition. Rats were pretreated for 2 weeks with sarpogrelate in drinking water (30 mg/kg per day; sarpogrelate-treated group) or equivalent volumes of drinking water (control group). Animals were pithed and prepared for spinal stimulation (C7-T1) of the cardioaccelerator sympathetic outflow or for intravenous (i.v.) bolus injections of noradrenaline. Both procedures produced tachycardic responses remaining unaltered after saline. Continuous i.v. infusions of 5-HT induced a cardiac sympatho-inhibition that was mimicked by the 5-HT receptor agonists 5-carboxamidotryptamine (5-CT; 5-HT1/5A), CP 93,129 (5-HT1B), or PNU 142633 (5-HT1D), but not by indorenate (5-HT1A) in both groups; whereas LY344864 (5-HT1F) mimicked 5-HT only in sarpogrelate-treated rats. In sarpogrelate-treated animals, i.v. GR 127935 (310 μg/kg; 5-HT1B/1D/1F receptor antagonist) attenuated 5-CT-induced sympatho-inhibition and abolished LY344864-induced sympatho-inhibition; while GR 127935 plus SB 699551 (1 mg/kg; 5-HT5A receptor antagonist) abolished 5-CT-induced inhibition. These results confirm the cardiac sympatho-inhibitory role of 5-HT1B, 5-HT1D, and 5-HT5A receptors in both groups; nevertheless, sarpogrelate treatment specifically unmasked a cardiac sympatho-inhibition mediated by 5-HT1F receptors. [ABSTRACT FROM AUTHOR]

Les tachycardies à QRS large mal tolérées du nourrisson posent le problème de leur diagnostic et de la prise en charge en urgence. Nous rapportons un cas de tachycardie à QRS large chez un nourrisson de 35 jours reçu pour détresse cardio-circulatoire. Le céur était morphologiquement normal à l'échographie cardiaque Doppler. Un traitement par une dose charge d'Amiodarone n'a pas permis de réduire cette tachycardie. Un retour en rythme sinusal a été obtenu après cardioversion par un défibrillateur externe semi-automatique type Lifeline. Un traitement d'entretien par Amiodarone per os est institué et le patient est en rythme sinusal à 03 mois.

Copyright of Archives of Cardiovascular Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Excessive intakes of sodium or fructose have been described as risk factors for hypertension. We hypothesized that even a moderately high fructose diet (6% fructose), either alone or in combination with high sodium (4% NaCl), may impair diuresis and renal and systemic vascular reactivity, contributing to the onset of high blood pressure in rats. Male Wistar rats were fed chow containing 4% NaCl (HS), 6% fructose (MHF), or both 4% NaCl and 6% fructose (HSMHF) for 6 weeks and had their diuresis, plasma creatinine, vascular reactivity of perfused kidneys and systemic arterial pressure evaluated. We found no differences in augmented diuresis among animals given HS, MHF, or HSMHF diets. After 6 weeks both the HS and HSMHF groups had increased weight in their left kidneys, but only the HSMHF group showed augmented plasma creatinine. The effects of phenylephrine on renal vascular perfusion pressure were similarly enhanced in kidneys from the HS, MHF, and HSMHF groups, but not on the systemic arterial pressure. Although when evaluated in anesthetized rats, only the HSMHF group presented augmented blood pressure, evaluation in conscious animals revealed that both the MHF and HSMHF diets, but not the HS alone, were able to induce tachycardia and hypertension. In conclusion, a MHF diet containing 6% fructose was enough to render the renal vascular bed hyperreactive to phenylephrine and to induce both hypertension and tachycardia. The combination of 6% fructose with 4% NaCl led to plasma accumulation of creatinine and accelerated the development of tachycardia. [ABSTRACT FROM AUTHOR]

Résumé La grande majorité des troubles du rythme à l’âge pédiatrique est représentée par des tachycardies supraventriculaires. L’évolution naturelle des tachycardies de la première année de vie est favorable. La prise en charge consiste en un traitement antiarythmique de quelques mois pour éviter les récidives et écarter le risque de cardiomyopathie rythmique. Au-delà de 5 à 10 ans, un traitement curatif par ablation endocavitaire peut être envisagé. Les troubles conductifs de l’enfant sont observés dans deux contextes distincts. Dans la période périnatale, il s’agit presque exclusivement de bloc auriculo-ventriculaire complet d’emblée d’origine immunologique. Les diagnostics de trouble conductif fait au-delà de cette période sont plus volontiers évolutifs, se présentant initialement comme des troubles conductifs partiels. La stimulation cardiaque permanente est indiquée en cas de bradycardie symptomatique ou de fréquence cardiaque inférieure à 50 battements par minute. Les troubles du rythme héréditaires ou canalopathies sont rares mais potentiellement létaux. Leur prise en charge doit se faire dans un centre spécialisé. La prévention de la mort subite dans ce contexte passe par des modifications du mode de vie, un traitement médical et/ou l’implantation d’un stimulateur cardiaque ou d’un défibrillateur automatique implantable. [ABSTRACT FROM AUTHOR]

Copyright of Obésité is the property of Lavoisier and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Summary: Study aims: Autonomic changes, especially those of sympathetic skin responses (SSR), during sequential water swallowing (SWS) have not been systematically investigated. This study aims to electrophysiologically examine these autonomic changes (SSR and heart rate) that occur during 50ml sequential water swallowing from a cup. Materials and methods: Fifty-eight normal healthy adults were included in the study. Their submental muscle activity, respiratory activity, heart rate changes, and sympathetic skin responses were recorded during 50ml water swallowing. In addition, we requested subjects to imagine drinking water as they did just before. The same recordings were performed during this imagination period. Results: SSR appeared at the beginning and at the end of SWS in 52% of subjects. A first sympathetic skin response was evoked at the onset of SWS, and a second one appeared 8.6±1.7seconds after the first one and at the end of swallowing. Similar double SSRs were also obtained during imagination in most investigated subjects (33 out of 35 of selected subjects in a total group of 58 subjects). Swallowing tachycardia was observed during the SWS-associated apnea period, but not during the imagination period. Heart rate significantly increased during the SWS-associated apnea period. Conclusion: The first SSR that appeared at the onset of swallowing is likely related to arousal. The appearance of a second response is a novel finding, which is probably related to the activity of subtil corticosubcortical networks. While discrete/single swallows can be used to evoke SSRs, SWS is unlikely to be clinically useful in its current form. In contrast, swallowing tachycardia could be a useful tool to examine dysphagic patients. [Copyright &y& Elsevier]

Abstract: Purpose: The existence of inter-atrial epicardial connections bridging the two atria at different levels has well been described and their implication in some forms of supraventricular arrhythmias is a known fact. However, up to date, little data exists in the literature showing their role in the mechanisms of focal atrial tachycardias, providing at the same time clear electroanatomical and activation maps using a three-dimensional, non-fluoroscopic mapping system. Patients and methods: We present the case of a 29-year-old woman with a focal atrial tachycardia with the origin in a pulmonary vein, manifested as a right atrial origin due to the conduction of the electrical impulse form the right inferior pulmonary vein (RIPV) to the postero-inferior right atrium (RA) via inter-atrial epicardial connections. Using a three-dimensional, non-fluoroscopic mapping system (CARTO, Biosense Webster), an RA activation map was created during tachycardia. Results: Radiofrequency (RF) application at the earliest endocardial breakthrough site situated in the postero-inferior RA changed the right atrial depolarization sequence without terminating the arrhythmia. Subsequently, a left atrium activation map was created showing the earliest endocardial breakthrough site at the level of the RIPV ostium and RF application at this level abolished the atrial tachycardia. Conclusion: Inter-atrial epicardial connections can be part of the substrate of some forms of supraventricular arrhythmias. Awareness of their existence is important to the electrophysiologist, since a better understanding of transseptal activation can avoid, in some cases, unnecessary RF applications at the level of the postero-septal right atrium, with a subsequent increase in procedural risk. [Copyright &y& Elsevier]

Copyright of Archives of Cardiovascular Diseases Supplements is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Abstract: Multiple mechanisms can explain a tachycardia associated or not with a heart disease. It is important to establish its origin, particularly if advanced heart disease is present, for the treatment. Complete electrophysiological study remains an important means of diagnosis. We report the case of a 39-year old man, who had a dilated cardiomyopathy since the age of 25 years and who complained of tachycardia. These symptoms were shown to be related to atrioventricular nodal re-entrant tachycardia at electrophysiological study and a specific treatment was indicated. [Copyright &y& Elsevier]

Copyright of EMC-Cardiologie-Angeiologie is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

A clinical case of spontaneous ventricular dysrythmia in a 47-year-old patient scheduled for ankle osteosynthesis is reported. During initial peripheral vein canulation, a spontaneous ventricular tachycardia occurred and disappeared spontaneously in about 3 min. It was decided to proceed with surgery. Thirty minutes after spinal anaesthesia, asystole occurred. Normal sinus rhythm was rapidly restored after basic life support. There was no harmful consequence for the patient. He had a history of repetitive monomorphic ventricular tachycardia (Gallavardin type). The aetiologies of asystole after spinal anaesthesia are well known and will be not discussed in the text. Although the origin of the asystole is unclear in this case, the literature on Gallavardin’s syndrome is reviewed, showing that a prolonged and complex preoperative assessment is not mandatory in this syndrome. [Copyright &y& Elsevier]

In this case report, we rendered a 22-year-old woman with the diagnosis of neurogenic thoracic outlet syndrome. We have evaluated her symptoms of palpitation with Holter monitorization during Roos test before and after surgery where transaxillary first rib resection and scalenectomy were performed. Postoperatively she improved and the tachycardia resolved. We propose that stellate ganglion or postganglionic efferent sympathetic fibers forming the cardiac plexus are exposed to compression while Roos test is being performed. Due to this irritation, there can be an increase in the cardiac sympathetic activity. [Copyright &y& Elsevier]