1. Attenuation of Haemodynamic Changes during Laryngoscopy and Endotracheal Intubation with Oral Gabapentin versus Oral Clonidine.
- Author
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Anand, P. Jothi, Raghavan, C. Venkat, and Kumar, S. Ramesh
- Abstract
INTRODUCTION During the administration of general anesthesia, the procedures of direct laryngoscopy and endotracheal intubation result in a significant rise in heart rate, arterial pressure, and dysrhythmias in around 90% of patients. These modifications can provide a significant risk to patients with brain or coronary diseases. The aim of present study is to assess the attenuation of hemodynamic changes during laryngoscopy and endotracheal intubation with oral gabapentin versus oral clonidine. MATERIAL AND METHODS The present double blind randomized controlled trial was conducted among patient undergoing elective surgeries under general anesthesia at Govt. Mohan Kumaramangalam Medical College, during the study period of one year. 90 patients were distributed to three groups using sealed envelope technique. Group A of patients received single dose oral 150 µg clonidine, Group B of patients received single dose oral 200 µg clonidine and Group C patients received single dose oral 800 mg gabapentin . Hemodynamic parameters were noted at different time interval and results were analyzed. RESULTS The mean age of subjects was between the age group of 40-50 years and male were higher in number as compared to female. The heart rate was higher in the clonidine 200 group as compared to other two but results were non-significant with (P>0.05). No Significant difference in mean SBP, DBP and MAP was observed at all time intervals. (p>0.05). CONCLUSION Oral clonidine and gabapentin reduce direct laryngoscopy haemodynamics. Gabapentin has fewer adverse effects than clonidine. Compared to -200mcg, 150mcg has no adverse effects. [ABSTRACT FROM AUTHOR]
- Published
- 2024