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Amaç: Bu çalışmada, 9 yıl içerisinde adrenal kitle nedeni ile ameliyat edilen olgularda konvansiyonel ve laparoskopik adrenalektominin sonuçlarının karşılaştırılması amaçlanmıştır.Gereç ve Yöntem: Adrenalektomi uygulanan 81 hasta çalışmaya dahil edildi. Grup 1 konvansiyonel, Grup 2 Laparaskopik cerrahi olarak hastalar iki grupa ayrıldı. İki grup, yaş, cinsiyet, vücut kitle indeksi (VKİ), Amerikan anestezistler derneği skoru (ASA), kitle lokalizasyonu, kitle büyüklüğü ve kitlenin hormonal aktivitesi, operasyon süresi, operasyonda kanama miktarı, yatış süresi, gıdaya başlama süresi, perioperatif mortalite, erken dönem komplikasyonlar ve 90 gün içinde hastaneye tekrar başvuru gibi özellikleri esas alınarak retrospektif olarak karşılaştırıldı. Bulgular: Grup 1’de 22, Grup 2’de 59 hasta mevcut idi. Gruplar arasında yaş, cinsiyet, VKİ, ASA skoru, tümör lokalizasyonu, operasyon endikasyonları, postoperatif komplikasyon, perioperatif mortalite ve 90 gün içinde tekrar başvuru açısından istatistiksel olarak anlamlı fark saptanmadı. Kitlenin hormonal aktivitesi Grup 2’de daha yüksek, boyutu ise daha küçük saptandı. Operasyon süresi (dak), ameliyatta kanama miktarı (ml), oral alım süresi (gün) ve hastanede yatış süresi (gün) Grup 1’de daha fazla ve istatiksel olarak anlamlı bulundu. Sonuç: Laparoskopik adrenalektomi uygun hastalarda, kısa operasyon süresi, az kan kaybı, oral gıdaya erken başlama süresi ve daha kısa hastanede kalış süresi gibi avantajları, ayrıca güvenli olması nedeni ile tercih edilmesi gereken cerrahi yöntem olmalıdır.

Purpose: The aim of this study was to compare the results of conventional and laparoscopic adrenalectomy in adrenal mass cases operated on during a 9-year period. Materials and Methods: A total of 81 patients who underwent adrenalectomy were included in the study. Patients were divided into two groups as; Group 1 - conventional surgery and Group 2 - laparoscopic surgery. Two groups were compared retrospectively on characteristics such as; age, sex, body mass index (BMI), American Society of Anesthesiologists' score (ASA), mass localization, mass size and hormonal activity of the mass, duration of operation, amount of bleeding in operation, duration of hospitalization, duration until food intake, perioperative mortality, early complications and readmission to hospital within 90 days. Results: There were 22 patients i n Group 1 and 5 9 patients in Group 2. No statistically significant difference was found between the groups in terms of age, sex, BMI, ASA score, tumor localization, indications for operation, postoperative complication, perioperative mortality and re-admittance within 90 days. The hormonal activity of the mass was higher and the mass was smaller in size in Group 2. The duration of operation (min), the amount of bleeding in the operation (ml), the duration until oral intake (days) and the length of hospital stay (days) were found to be statistically significantly higher in Group 1. Conclusion: Laparoscopic adrenalectomy should be the preferred surgical method because of its short duration of operation, low blood loss, early onset of oral food intake and shorter hospital stay, as well as its safety. [ABSTRACT FROM AUTHOR]

Aim: In this study, we aimed to compare the results of conventional and laparoscopic adrenalectomy in patients with adrenal masses greater than 6 cm. Material and Methods: Thirty-six patients with tumor size greater than 6 cm who underwent adrenalectomy between January 2011 and January 2018 were included in the study. Patients were divided into two groups as Group 1 conventional and Group 2 Laparoscopic surgery. The two groups were retrospectively compared in terms of age, sex, mass localization, mass size, duration of operation, amount of bleeding, duration of hospitalization, duration of onset of food intake, perioperative mortality, early period complications and re-admission to the hospital within 90 days. P<0.05 was considered statistically significant. Results: There were 13 patients in Group 1 and 23 patients in Group 2. There was no statistically significant difference between the groups in terms of age, sex, tumor localization, tumor size, indications for operation, postoperative complications, perioperative mortality and readmission within 90 days. Duration of operation (min), amount of bleeding (ml), duration of oral intake (day) and duration of hospitalization (day) were higher in Group 1 and statistically significant. Conclusion: Laparoscopic adrenalectomy has demonstrated advantages in patients with a mass greater than 6 cm compared to conventional surgery, such as short operation duration, less blood loss, early onset of oral food intake and shorter hospital stay. It can be safely used in patients with a mass larger than 6 cm. [ABSTRACT FROM AUTHOR]

Renal cell carcinoma (RCC) is the most common primary malignant tumor of renal parenchyma. RCC metastases most commonly occur in the lung, liver, bone, brain, lymp nodes, and contralateral kidney. Adrenal gland metastasis from renal cell carcinoma is generally ipsilateral, and frequently clinically and functionally silent. Synchronous bilateral adrenal gland metastases from RCC are very rare, and 18 other cases were reported in the literature. In this article, we aimed to present a case of bilateral synchronous adrenal metastases from left kidney RCC in a 58-year-old man with radiologic findings and review the literature. [ABSTRACT FROM AUTHOR]

Two rabbit (Oryctolagus cuniculus) inbred strains (AX/JU and IIIVO/JU) have been used for genetic analysis of quantitative traits related to dietary cholesterol susceptibility. Application of the AFLP (amplified fragment length polymorphism) technique with 15 primer combinations revealed 226 polymorphisms between the 2 inbred strains. A total of 57 animals from a backcross progeny (IIIVO/JU × [IIIVO/JU × AX/JU]F[sub 1] ) were available for the genetic analysis. These backcross animals were fed a commercial pelleted diet fortified with 0.3% w/w cholesterol during a test period that lasted five weeks. A male genetic map could be constructed, consisting of 12 linkage groups and 103 AFLP markers. Linkage analysis between the cholesterol-related traits and marker loci revealed a significant LOD score for the relative weight of adrenal glands in males (LOD score = 3.83), whereas suggestive linkages were found for basal serum total cholesterol levels in females (LOD score = 2.69), for serum total cholesterol response (area under the curve) in males (LOD score = 2.21), and for hematocrit in males (LOD score = 3.24).Key words: adrenal, AFLP, cholesterol, hematocrit, QTL, rabbit.Deux lignées fixées du lapin (Oryctolagus cuniculus), AX/JU et IIIVO/JU, ont été employées pour réaliser une analyse génétique de caractères quantitatifs liés à une sensibilité au cholestérol alimentaire. L'utilisation de la technique AFLP (« amplified fragment length polymorphism ») avec 15 combinaisons d'amorces a révélé 226 polymorphismes entre les deux lignées fixées. Une progéniture de 57 animaux backcross ((IIIVO/JU × [IIIVO/JU × AX/JU]F[sub 1] ) était disponible pour cette analyse. Ces animaux ont été nourris avec une diète commerciale supplémentée de 0,3 % de cholestérol (sur une base de masse) durant une période d'expérimentation de cinq semaines. Une carte génétique mâle a été produite, comprenant douze groupes de liaison et 103 marqueurs AFLP. Une analyse de liaison entre les caractères liés au cholestérol et les marqueurs a révélé un score LOD significatif (3,83) pour la masse relative des glandes surrénales, tandis que des liaisons suggestives ont été notées pour le taux de cholestérol basal dans le sérum chez les femelles (LOD = 2,69), la réponse totale au cholestérol du sérum chez les mâles (LOD = 2,21) et l'hématocrite chez les mâles (LOD = 3,24).Mots clés : surrénal, AFLP, cholestérol, hématocrite, QTL, lapin.[Traduit par la Rédaction] [ABSTRACT FROM AUTHOR]

Amaç: Sürrenal metastatik kitlelerinin çoğunluğu akciğer karsinomu kökenlidir. Daha nadiren gastrointestinal kökenli veya primer olarak karşımıza çıkabilir. Bu çalışmanın amacı primeri akciğer karsinomu dışında olan sürrenal primer veya metastazlarında F-18 FDG PET/BT'nin yerinin araştırılmasıdır. Yöntem: Çalışmaya 9 hasta (6 E, 3 K; yaş ortalaması: 57,3) dahil edilmiştir. Hastaların ikisinde yeniden evreleme, beşinde yanıt değerlendirme ve ikisinde primerin tespit edilmesi amacıyla yapılan F-18 FDG PET/BT görüntüleri ve dosya bilgileri retrospektif olarak deneyimli bir nükleer tıp uzmanı tarafından değerlendirilmiştir. Bulgular: Hastaların üçünde sol ve altısında sağ sürrenal bezde ortalama 30,63 mm boyutunda FDG tutulumu artmış (ortalama SUVmax=11,4±10,3) lezyon ve ek olarak hastaların 5'inde akciğer, 5'inde mediasten, 4'ünde karaciğer, üçünde boyun, ikisinde abdomen lenf nodu tutulumu ve birinde ek olarak periton tutulumu izlenmiştir. Hastaların primer tümörleri; ikisinde primer sürrenal karsinom, beşinde kolon karsinomu, birinde mide ve birinde primeri bilinmeyen olarak PET/BT'de ve/veya patolojik olarak tespit edilmiştir. Sonuç: Primer sürrenal veya akciğer dışı metastatik sürrenal kitlelerinde özellikle primer odak araştırmada olmak üzere tanı ve takipte PET/BT etkili bir parametredir. [ABSTRACT FROM AUTHOR]