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3 results on '"substitutional therapy"'

1. Influence of buprenorphine replacement therapy

Author

Despotović Milena, Despotović Mile, Aleksopulos Hristos, Aleksandrić Jelena, and Marinović Nela

Subjects
buprenorphine, substitutional therapy, psychoactive substances, Nursing, RT1-120
Abstract

Introduction. Opiates and opoids create physical and psychological addiction. Official statistics on the number of opiate addicts in Serbia doesn't exist. The United Nations Office on Drugs and Crime estimates that in 2014 some 29 million people in the world are dependent on some sort of drug. Method. This paper belongs to a group of review papers. Based on the key words (buprenorphine, substitution therapy, psychoactive substances), as well as various databases, isolated references were analyzed, systematized and presented in this paper. Discusion. Substitution therapy is most often used therapy method. Substitution therapy is a form of therapy in which an antagonist, a new substance with properties and actions of similar substances, is used. Agonists are used to provide a more controlled form of addiction. The most commonly used antagonist is methadone whose use in Europe reaches 90% of total opioid substitution, although it has been lately replaced by buprenorphine, a partial agonist-antagonist and is most commonly used in France. Researches show that buprenorphine causes less physical dependence than methadone and other substitutes. It also appears that there is less potential for drug abuse when buprenorphine is used instead of methadone. Conclusion. Many aspects of the effects of buprenorphine have not been fully tested. Social reintegration is an important aspect of social rehabilitation of opioid addicts, and it is therefore extremely important to recognize psychological and social factors that can act as protective factors, but also as risk factors. As the impact of buprenorphine on the outcomes of social rehabilitation has not been studied so far, it is necessary to design new studies that would go in this direction.

Published
2017

2. THE SIGNIFICANCE OF SUBCLINICAL HYPOTHYROIDISM AND ITS SUBSTITUTIONAL THERAPY INFLUENCE ON DEVELOPMENT OF CARDIOVASCULAR PATHOLOGY

Author

T.I. Rodionova and V.V. Samitin

Subjects
cardiovascular risk, L-thyroxine, subclinical hypothyroidism, substitutional therapy, Medicine (General), R5-920
Abstract

This review presents the modern data concerning influence ofsubclinicalhypothyroidism on morphology and functional state of myocardium and arterial vessels, traditional and "new" cardiovascular risk factors. The riskof clinically significant complications (cardiovascular diseases, disorders ofhemostasis and changes in lipidexchange) connected with subclinical hypothyroidism is under research. The data on the effects of subclinical hypothyroidism substitutional therapy are highlighted in the work

Published
2008

3. The Importance of Substitution Programmes in Drug Addiction Therapy System

Author

MÁLKOVÁ, Gabriela

Subjects
substituční léčba, drugs, substitutional therapy, závislost, metadon, buprenorfin, drogy, methadone, buprenorphine, addiction
Abstract

The title of my thesis is: The Importance of Substitution Programmes in Drug Addiction Therapy System. Substitution therapy has its unique place especially in the treatment of opioid addictions. It helps individuals with stabilization and improvement of their social, somatic and mental state and it is important for the society, when public spending on the care and repression are reduced thanks to substitution treatment. In this bachelors thesis I deal with the issue of the effects of substitution therapy on the lives of people who use it for a long time. First, in the theoretical part, I define the issues concerning the addiction on non-alcohol drugs and then I deal with substitution therapy, its history, its current situation, its forms, types and components that substitution therapy includes. Attention in this section is paid to the effectiveness in terms of individual as well as social; therefore, I focus also on the disadvantages and difficulties that are associated with substitution therapy. As the objective of the thesis I chose to discover the importance of substitution programmes in drug addiction treatment. To achieve this objective, I defined two subobjectives, namely: Mapping the subjective evaluation of mental, somatic and social satisfaction of persons included in a substitution programme, and the comparison of mental, somatic and social situation prior and after inclusion of the client in a substitution programme. Given these objectives, I established three research questions that ask about the effects of substitution treatment on the social, somatic and mental aspects of the respondents. The research was conducted in a qualitative form, by the method of interviewing and the technique of semi-structured interviews. The research results have confirmed the improvements or stabilization of social, somatic and mental aspects of persons included in long-term substitution programmes. As the core finding I consider the fact that there is some abuse of substitution therapy, in which case its effectiveness in these three levels is less visible than in persons observing substitution therapy in the prescribed manner. The results of my thesis can serve for the needs for further research, to inform the general public and professionals, and they also have a practical use when working with clients in substitution treatment.

Published
2011

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