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Purpose: Inflammation of various degrees is common among humans. There are associated side effects with orthodox delivery systems and anti-inflammatory agents; hence, the study investigated the characteristics of herbal lipospheres and the anti-inflammatory potency of the lipospheres formulated from Pentaclethra macrophylla with the view to having a drug with a better delivery system and lesser side effects. Methods: Herbal lipospheres were formulated using solidified reverse micellar solutions (SRMS) of P90H and goat fat and characterized for particle size and morphology, pH time dependent analysis, encapsulation efficiency (EE%), and Fourier Transform infrared spectroscopy. The in vitro antinociceptive and anti-inflammatory studies were carried out using membrane stabilization by hypotonicity-induced hemolysis and the determination of anti-platelet aggregatory activity models. The in vivo antinociceptive and anti-inflammatory studies on egg albumin- and formaldehyde-induced arthritis models were conducted. A total white blood cell count and differential blood count were carried out on the rats. Results: The results showed that there was no change in pH for the PM-unloaded lipospheres and 2.5 g of PM-loaded lipospheres from day 1 to day 7, but there was a mild variation in the rest of the formulations. The EE ranged from 35.2% to 94%, increasing according to the drug concentration. The photomicrographs of the lipospheres showed that the particles were spherical in shape. The particle sizes were within the acceptable range for lipospheres. FTIR showed no interaction. In the arthritis study, PM-loaded lipospheres inhibited edema consistently throughout the duration of observation. Inhibition of the membrane increased steadily with an increase in concentration of PM in the lipospheres and the standard drug. The platelet aggregatory inhibition decreased steadily with an increase in concentration of the PM in the lipospheres as well as the standard. The T50 dose of PM had the highest percentage of WBC, and it decreased as the treatment doses increased from T100 to T200. There were no significant differences among the Neutrophil counts of the different groups. Conclusions: The study, therefore, showed that the methanol extract of Pentaclethra macrophylla formed efficient herbal lipospheres with antinociceptive and anti-inflammatory activities. [ABSTRACT FROM AUTHOR]

This study investigates the phytochemical contents, antioxidants and cytotoxic activities of Lannea egregia Engl. & K. Krause stem bark extracts. Secondary metabolites were extracted using n-hexane, ethyl acetate, and ethanol by successive maceration. The concentrated extracts were subjected to preliminary phytochemical screening using standard procedures. The crude flavonoid was obtained from the plant material using Harborne’s method and then profiled using high-performance liquid chromatography (HPLC). The antioxidant activities of the plant extract were assessed using reducing power assay and DPPH scavenging activity, while the cytotoxic activity was determined using the brine shrimp lethality assay. The crude extract of n-hexane or LEHe (0.86%), ethyl acetate or LEEa (1.42%), ethanol or LEEt (3.32%), and flavonoid or LEF (9.7+-0.01%) were obtained from the plant material, with flavonoids, anthraquinone, terpenoids, and tannins detected. The ethyl acetate extract and the crude flavonoid have the highest and comparable DPPH radical scavenging activity at IC50 of 22.98 ± 0.07 μg/mL and 22.48 ± 1.02 μg/mL respectively, the greatest reducing property being exhibited by the ethanol extract. The most cytotoxic activity was observed in the n-hexane extract at LC50 of 8.70 ± 0.58 μg/mL. HPLC detected catechin, p-coumaric acid, ferulic acid, rutin, apigenin, kaempferol and quercetin. In conclusion, Lannea egregia stem bark extracts possess antioxidant and cytotoxic activities and could be explored for new drugs in the management of cancer.

This study reports the use of aqueous mango stem bark extract (MSBE) as a source of a relatively cheap and easily accessible reducing and stabilizing agent for the biosynthesis of silver nanoparticles (AgNPs). The biosynthesis was conducted at 80 °C and pH 9 within 30 min. The FTIR and UV–Vis spectroscopic characterization of the MSBE provided evidence of chromophoric phytoconstituents with reducing functional groups. These constituents served as reducing and stabilizing agents as they were observed in the FTIR spectrum of the AgNPs. Similarly, the SEM micrograph and TGA thermogram indicated the presence of MSBE phytoconstituents on the surface of the synthesized AgNPs. The HRTEM revealed the polycrystalline nature of the AgNPs which adopted quasi-spherical and elliptical morphologies with sizes in the range 5–50 nm. The AgNPs showed remarkable catalytic activity in the degradation of methylene blue dye with a pseudo-first-order rate constant of 0.0089 s−1. The degradation was completed within 280 s. In addition, the AgNPs displayed improved antibacterial activity in comparison with the MSBE against clinical pathogens. Based on the findings in this study, AgNPs can serve as a potential catalyst in water treatment and also as an antimicrobial agent in disinfectant formulations. [ABSTRACT FROM AUTHOR]

The study was conducted to determine the effect of Ficus sur stem bark extract on the fertility of Yankasa sheep. A total of twenty (20) ewes aged 12-19 months old and 5 rams were used in the study. The ewes were randomly allotted to 5 treatments and replicated 4 times. One ram was assigned to each treatment group in a Completely Randomized Design (CRD). All groups were administered the extract orally, except treatment one which served as control. The doses were 5, 10, 15, and 20% for treatments 2, 3, 4, and 5 respectively. The phytochemistry revealed the presence of Alkaloids (2.63), Flavonoids (13.57), Resins (1.03), Saponins (1.08), Glycosides (0.74), Tannins (5.52), Steroids (9.11), Terpenoids (12.03) and Phenols (6.70%). Of the 16 does, three (3) exhibited heat within 24-48 hours, 8 in 48-72 hours, 4 between 72-96 hours, and 1 expressed heat within 96 -120 hours after Ficus sur stem back extract administration. The oestrus response and conception rates were 0, 100, 100, 100 and 100% and 0, 100, 100, 100 and 75% for treatments 1, 2, 3, 4 and 5 respectively. A positive and significant correlation was found between heat and concentration (P<0.01), dose and concentration (P< 0.01), and dose and heat (P<0.01). It could therefore be concluded that synchronizing activity exhibited by Ficus sur stem bark extract may be due to the presence of steroid properties which play a role in animal cyclicity as revealed by the phytochemical analysis. Furthermore, the ewes that received lower concentrations (dose) expressed oestrus signs faster than those that received higher concentrations. It could therefore be recommended that 5% concentration of methanol extract of Ficus sur stem bark is good for fertility improvement and oestrus synchronization in sheep. [ABSTRACT FROM AUTHOR]

To address the growing demand for natural sources of drugs, in addition to chemical ones, the present study aimed to explore the phytochemical and biological activity of acetone stem bark extract of Albizia lebbeck. The phytoconstituents of the derivatized acetone stem bark extract were analyzed using Gas Chromatography–Mass Spectrometry (GC-MS), while the phenolic and flavonoid compounds were analyzed using High-Performance Liquid Chromatography (HPLC). Six bacterial strains (Serratia marcescens, Acinetobacter johnsonii, Agrobacterium tumefaciens, Bacillus subtilis, Erwinia carotovora, Escherichia coli) and three fungal strains (Rhizoctonia solani, Penicillium italicum, Fusarium oxysporum) were evaluated for antimicrobial activity. Furthermore, in vitro cytotoxicity was assessed against three cancer cell lines (PC-3, Caco-2, and MCF-7). Our findings indicated that the acetone extract of A. lebbeck stem bark was rich in fatty acids, with a predominance of oleic acid (19.2%). Additionally, eight phenolic acids, primarily cinnamic acid, and eight flavonoids, primarily chrysoeriol and hesperidin, were identified. It was found that the acetone extract of the A. lebbeck stem bark exhibited a high potential antibacterial effect against B. subtilis and S. marcescens and evident antifungal activity against F. oxysporum. Based on the calculated selectivity index, PC-3 cells were found to have the highest value (2.95), followed by Caco-2 cells (1.92) and MCF-7 cells (1.34). These results suggest the richness of A. lebbeck stem bark in phytochemicals with promising antimicrobial and cytotoxic properties. [ABSTRACT FROM AUTHOR]

Stigmasterol and Stigmasterone from Methanol Extract of Calophyllum soulattri Burm. F. Stem Bark. Calophyllum soulattri Burm. F. has been widely used for herbal medicine. Phytochemical investigation of C. soulattri contains a secondary metabolite of the steroid class. Steroid compounds have various biological activities, such as anti-inflammatory, antioxidant, antiproliferative, antibacterial, antimalarial, and anticancer. Two secondary metabolites steroids have been isolated and identified from the stem bark extract of C. soulattri. Isolation was carried out through the extraction (maceration), fractionation, and purification stages. Maceration is carried out using methanol as a solvent. Fractionation was carried out by vacuum liquid chromatography (VLC), and purification was by flash column chromatography. Identification of combined fractions and determination of pure isolates were used through thin-layer chromatography (TLC). The solvent used in the chromatography methods was a mixture of n-hexane and ethyl acetate. The structure isolates were identified by FTIR, 1H NMR, and 13C NMR and compared with literature data. Secondary metabolites steroids that have been isolated are identical compounds to stigmasterol and stigmasterone.

To address the growing demand for natural sources of drugs, in addition to chemical ones, the present study aimed to explore the phytochemical and biological activity of acetone stem bark extract of Albizia lebbeck. The phytoconstituents of the derivatized acetone stem bark extract were analyzed using Gas Chromatography–Mass Spectrometry (GC-MS), while the phenolic and flavonoid compounds were analyzed using High-Performance Liquid Chromatography (HPLC). Six bacterial strains (Serratia marcescens, Acinetobacter johnsonii, Agrobacterium tumefaciens, Bacillus subtilis, Erwinia carotovora, Escherichia coli) and three fungal strains (Rhizoctonia solani, Penicillium italicum, Fusarium oxysporum) were evaluated for antimicrobial activity. Furthermore, in vitro cytotoxicity was assessed against three cancer cell lines (PC-3, Caco-2, and MCF-7). Our findings indicated that the acetone extract of A. lebbeck stem bark was rich in fatty acids, with a predominance of oleic acid (19.2%). Additionally, eight phenolic acids, primarily cinnamic acid, and eight flavonoids, primarily chrysoeriol and hesperidin, were identified. It was found that the acetone extract of the A. lebbeck stem bark exhibited a high potential antibacterial effect against B. subtilis and S. marcescens and evident antifungal activity against F. oxysporum. Based on the calculated selectivity index, PC-3 cells were found to have the highest value (2.95), followed by Caco-2 cells (1.92) and MCF-7 cells (1.34). These results suggest the richness of A. lebbeck stem bark in phytochemicals with promising antimicrobial and cytotoxic properties.

A study on physicochemical characteristics of Ceiba petandra and Lannea kerstingii stem bark extracts cream being developed for the treatment of topical dermatophytic infections has been carried out to assure safe, effectiveness and stability during storage and usage. The stem barks of Ceiba petandra and Lannea kerstingii were extracted with methanol and ethyl acetate respectively. The obtained extracts and their combinations were formulated into creams using modified Aqueous Cream BP base at concentrations ranging from 0.4 to 3.2%w/w. Physical and chemical characteristics of the creams such as stability, viscosity, pH, diffusion, irritancy and elegance were evaluated. Ketoconazole cream was used as the reference product. Creams prepared with each extract alone exhibited favorable characteristics in terms of spread ability, non-irritancy, stability and diffusivity. Creams formulated with Ceiba petandra were most stable with pH ranges of 6.21 to 7.13. Those formulated Lannea kerstingii were more acidic. Creams formulated with the combinations of the two extracts exhibited some levels of incompatibility, which increased with increasing extract concentrations. The rate of diffusion of the extracts from cream base increased with time and was generally more at 37o C as compared to that at 25o c .Cream formulations of the stem bark extracts of Ceiba petandra and Lannea kerstingii but not their combinations using modified Aqueous Cream (BP) possess satisfactory physicochemical characteristics.

Background: Salacial lehmbachii stem bark is used traditionally for the treatment of diabetes mellitus and its associated complications. Treatment of diabetes is necessary to reduce these complications. Methods: In this study, the antidiabetic and antihyperlipidemic potential of S. lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg p.o. daily for 21 days. Blood glucose levels, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were assessed in the animals. Results: Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction in blood glucose levels when compared with diabetic control. The elevated levels of serum cholesterol, triglycerides, LDL, and VLDL were significantly (p<0.01) reduced by S. lehmbachii stem bark extract, while the level of HDL significantly (p<0.01) increased. Conclusions: The results obtained suggest that S. lehmbachii stem bark extract has the potential to treat diabetes condition and hyperlipidemic disorders. [ABSTRACT FROM AUTHOR]

Introduction: To evaluate the antimicrobial activities of hexane, ethyl acetate, and methanol extracts from the stem bark of Garcinia latissima Miq. Method: The G. latissima Miq. was collected from Bogor. This study uses multilevel maceration extraction methods. The antimicrobial activity was determined by the good diffusion method and the broth dilution method. Result: The ethyl acetate extracts of stem bark were active against Bacillus subtilis, aeruginosa Staphylococcus aureus, and Ps aeruginosa, and virtually inactive against Escherichia coli, Candida albicans, and Trichophyton mentagrophytes. The methanol extracts of stem bark were active against B. subtilis and S. aureus, and virtually inactive against E. coli, P. aeroginosa, C. albicans, and T. mentagrophytes. The hexane extracts of stem bark were inactive against B. subtilis, S. aureus, E. coli, P. aeroginosa, C. albicans, and T. mentagrophytes. The 2% methanol extracts of G. latissima Miq. stem bark showed the maximum zone of inhibition against B. subtilis (10.70±0.638 mm), followed by the methanol extracts of G. latissima Miq. stem bark against S. aureus (10.38±0.653 mm). 2% Ethyl acetate extracts of G. latissima Miq. stem bark exhibited a maximum zone of inhibition against B. subtilis (10.35±0.867 mm) followed by P. aeruginosa (10.07±0.971 mm). The results of the antibacterial activity showed that the MeOH extract of G. latissima Miq. stem bark exhibited activities against B. subtilis (MIC/MBC = 625 ppm/2500 ppm)and S. aureus (MIC/MBC = 2500 ppm/5000 ppm). The ethyl acetate extract of G. latissima Miq. stem bark exhibited activities against P. aeruginosa (MIC/MBC = 5000 ppm/5000 ppm) and B. subtilis (MIC/MBC > 5000 ppm/5000 ppm). Conclusion: The results of the present study revealed most valuable information and also support the continued sustainable use of G. latissima Miq. stem barks in a traditional system of medicine. [ABSTRACT FROM AUTHOR]

The objective of this study was to evaluate the antimicrobial potential of methanol, acetone and distilled water stem bark extracts from Canarium odontophyllum against Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 6633, Escherichia coli ATCC 25932, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii strain sensitive, Candida albicans ATCC 64677, Candida glabrata ATCC 90028, Aspergillus niger and Fusarium solani M2781. The extracts from C. odontophyllum stem bark from 3.125 mg/ml to 25 mg/ml were screened against the tested microorganisms using disc diffusion method. The Minimum inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts against susceptible organisms were determined using microbroth dilution method and streak-plate technique, respectively. From the antibacterial screening assay, the growth of S. aureus, B. cereus and A. baumannii were inhibited by methanol extract whereas the acetone extract was capable of inhibiting all the tested microorganisms except E.coli, F. solani and A. niger. The lowest MIC value for methanol extract was against A. baumannii (0.195 mg/ml) whereas its MBC value was twice its MIC value (0.391 mg/ml), indicating that methanol extract was bacteriostatic against A. baumannii. While for acetone extract, S. aureus showed bactericidal effect with equal MIC and MBC values at 0.195 mg/ml. In conclusion, stem bark of C. odontophyllum has the potential to be the source of antibacterial agent and can be exploited as an alternative phytoantimicrobial. [ABSTRACT FROM AUTHOR]

A methanolic crude extract of Parkia biglobosa was prepared and later partitioned in succession with different solvents of increasing polarity ranging from n-hexane, chloroform and ethyl acetate to butanol. Phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, flavonoids, steroids, glycoside and sugars. The inhibition zones exhibited by the extract against the tested bacteria ranged between 14 ± 0.00 mm (against Escherichia coli) and 28 ± 0.71 mm (against Pseudomonas aeruginosa). The MIC of the methanolic extract of P. biglobosa against isolates ranged between 0.63 mg/mL and 5 mg/mL, while the MIC values exhibited by the n-hexane and aqueous fractions ranged between 0.63 mg/mL and 10 mg/mL. Overall the extract and fractions of P. biglobosa used in this work were found to possess antimicrobial properties which compared favourably with those of streptomycin. These observations make this plant a potential source of bioactive compounds that can be used in management of bacterial infections. The use of this plant as herbal medicaments in African countries and the reports on the toxicity of the plant further show that the plant is non-toxic to humans.

Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.A casca do caule de Bowdichia virgilioides H.B.K (Fabaceae), conhecida localmente como sucupira-preta, é um remédio popular muito utilizado para tratar inflamações. Com o objetivo de validar sua crença popular, o extrato etanólico de B. virgilioides foi avaliado em vários modelos experimentais de inflamação e nocicepção. O extrato administrado, via oral, em doses de 100 a 1000 mg/kg de peso corporal produziu inibição significativa no edema de pata induzido por carragenina, no aumento na permeabilidade vascular induzido por acido acético, no volume de exudato e na migração leucocitária no teste de pleurisia induzida por carragenina, bem como no peso de granulomas induzidos por pelotas de algodão, em ratos. Em camundongos, o EE Bv reduziu o número de contorções abdominais induzidas por ácido acético e a lambedura da pata na segunda fase do teste da formalina. Esses resultados validam o potencial anti-inflamatório da casca de Bowdichia virgilioides e referendam seu uso tradicional em condições inflamatórias.

A methanolic crude extract of Parkia biglobosa was prepared and later partitioned in succession with different solvents of increasing polarity ranging from n-hexane, chloroform and ethyl acetate to butanol. Phytochemical screening of the extract revealed the presence of alkaloids, tannins, saponins, flavonoids, steroids, glycoside and sugars. The inhibition zones exhibited by the extract against the tested bacteria ranged between 14 ± 0.00 mm (against Escherichia coli) and 28 ± 0.71 mm (against Pseudomonas aeruginosa). The MIC of the methanolic extract of P. biglobosa against isolates ranged between 0.63 mg/mL and 5 mg/mL, while the MIC values exhibited by the n-hexane and aqueous fractions ranged between 0.63 mg/mL and 10 mg/mL. Overall the extract and fractions of P. biglobosa used in this work were found to possess antimicrobial properties which compared favourably with those of streptomycin. These observations make this plant a potential source of bioactive compounds that can be used in management of bacterial infections. The use of this plant as herbal medicaments in African countries and the reports on the toxicity of the plant further show that the plant is non-toxic to humans. [ABSTRACT FROM AUTHOR]

Abstract: Aim of the study: The ethanolic stem bark extract of Harungana madagascariensis (Hypericaceae), (Choisy) Poir were evaluated for their activities on Trichomonas gallinae (Rivolta) Stabler isolated from the pigeon (Columba livia). It was also tested for their anti-malarial activity on N67 Plasmodium yoelii nigeriensis (in vivo) in mice and on Plasmodium falciparum isolates in vitro. Materials and methods: The anti-trichomonal screening was performed in vitro usingTrichomonas gallinae culture. The minimum lethal concentration (MLC) is the lowest concentration of the test extract in which no motile organisms were observed. The anti-malarial effects were determined in-vivo for suppressive, curative and prophylactic activities in mice receiving a standard inoculum size of 1×107 (0.2ml) infected erythrocytes of Plasmodium yoelii nigeriensis intraperitoneally, and the in vitro was performed against 3 isolates of Plasmodium falciparum in a candle jar procedures. Results: The IC50 of the extract and metronidazole (MDZ) (Flagyl) on Trichomonas gallinae at 48h are 187 and 1.56μg/ml. The IC50 of the extract, chloroquine (CQ) and artemether (ART) on Plasmodium falciparum are between 0.052 and 0.517μg/ml for the extract and 0.021 and 0.0412μg/ml for ART and CQ, respectively. The actions of the extract in in vivo study on Plasmodium yoelii nigeriensis showed that in both suppressive and prophylactic tests the percentages chemo-suppressive were between 28.6–44.8% and 30.2–78.2% respectively, while only 80mg/kg of the extract reduced the parasitaemia level when compared to the control and the standard drugs in curative test. Conclusions: Harungana madagascariensis stem bark extract therefore exhibited significant anti-protozoan effects against Trichomonas and Plasmodium both in vivo and in vitro. [Copyright &y& Elsevier]

The complimentary antioxidant and anti-inflammatory effects of Harungana madagascariensis tem-bark thanolic extract on the reactive oxygen species (ROS) markers induced in the pathogenesis of diabetes mellitus and carrageenan-induced oedema were examined. The study was carried out on normal and alloxan induced diabetic rats. Oedema was induced by injecting 0.1mL of 1% carrageenan suspension in the right hind paw of rats. The Glutathione (GSH), Lipid peroxidation, Superoxide dismutase (SOD) and Catalase (CAT) were estimated by standard spectrophotometric methods, while the anti-inflammatory effect was evaluated using plethysmometer. The antioxidant activity was estimated using 1,1-diphenyl-2 picryl-hydrazyl (DPPH) photometric assay techniques. Administration of ethanolic extract of Harungana madagascariensis stem bark was found to reduce glucose level in diabetic animals and oedema size formation in the right hind paw of rats. Radical scavenging capacity was exhibited by increase in reduced glutathione (GSH) and a decrease in the concentrations of malondialdehyde (MDA) in alloxan-induced diabetic rats (in vivo) and against DPPH (in-vitro). The antidiabetic, antioxidant and anti-inflammatory activities of the plant extract could be complementary by reducing the high levels of inflammatory and oxidative stress markers, which have been associated with the diabetic condition. These could possibly explain the ways the plant produce its effects against diabetic conditions. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the hepatoprotective activity of crude aqueous and ethanol stem bark extracts of Pterocarpus santalinus (Fabaceae) using CCl4 induced hepatic damage in male Wistar albino rats. Materials and Methods: The aqueous (45 mg/ml) and ethanol (30 mg/ml) extracts of stem bark in 1% gum tragacanth was administered orally for 14 days and the hepatoprotective activity studied in CCl4 induced hepatic damage model. The hepatoprotective activity was assessed using various biochemical parameters like serum bilirubin, protein, alanine transaminase, aspartate transaminase and alkaline phosphatase along with histopathological studies of liver tissue. Results: There was a significant increase in serum levels of bilirubin, alanine transaminase, aspartate transaminase and alkaline phosphatase with a decrease in total protein level, in the CCl4 treated animals, reflecting liver injury. In the aqueous and ethanol extracts treated animals there was a decrease in serum levels of the markers and significant increase in total protein, indicating the recovery of hepatic cells. Histological study of aqueous extract treated group exhibited moderate accumulation of fatty lobules and cellular necrosis where as ethanol extract treated animals revealed normal hepatic cords without any cellular necrosis and fatty infiltration. Conclusion: The ethanol and aqueous stem bark extract of P. santalinus afforded significant protection against CCl4 induced hepatocellular injury. [ABSTRACT FROM AUTHOR]

Background Salacial lehmbachii stem bark is used traditionally for the treatment of diabetes mellitus and its associated complications. Treatment of diabetes is necessary to reduce these complications. Methods In this study, the antidiabetic and antihyperlipidemic potential of S. lehmbachii ethanol stem bark extract was evaluated in alloxan-induced diabetic rats at a dose of 100 mg/kg, 200 mg/kg, and 400 mg/kg p.o. daily for 21 days. Blood glucose levels, serum total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL) were assessed in the animals. Results Treatment of alloxan-induced diabetic rats with S. lehmbachii stem bark extract showed significant (p<0.01) reduction in blood glucose levels when compared with diabetic control. The elevated levels of serum cholesterol, triglycerides, LDL, and VLDL were significantly (p<0.01) reduced by S. lehmbachii stem bark extract, while the level of HDL significantly (p<0.01) increased. Conclusions The results obtained suggest that S. lehmbachii stem bark extract has the potential to treat diabetes condition and hyperlipidemic disorders.