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Humanities and Social Sciences (HSS) are undergoing the transformation of spatialization and quantification. Geo-computation, with geoinformatics (including RS: Remote Sensing; GIS: Geographical Information System; GNSS: Global Navigation Satellite System), provides effective computational and spatialization methods and tools for HSS. Spatial Humanities and Geo-computation for Social Sciences (SH&GSS) is a field coupling geo-computation, and geoinformatics, with HSS. This special issue accepted a set of contributions highlighting recent advances in methodologies and applications of SH&GSS, which are related to sentiment spatial analysis from social media data, emotional change spatial analysis from news data, spatial analysis of social media related to COVID-19, crime spatiotemporal analysis, “double evaluation” for Land Use/Land Cover (LUCC), Specially Protected Natural Areas (SPNA) analysis, editing behavior analysis of Volunteered Geographic Information (VGI), electricity consumption anomaly detection, First and Last Mile Problem (FLMP) of public transport, and spatial interaction network analysis for crude oil trade network. Based on these related researches, we aim to present an overview of SH&GSS, and propose some future research directions for SH&HSS.