5,923 results on '"sodium pertechnetate Tc 99m"'
Search Results
2. Simplification of Low Level Internal Dosimetry (SOLLID)
- Published
- 2023
3. Inhalation Low Dose Radionuclide Therapy in Treatment COVID-19
- Author
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Andrey Kaprin, general director of the National Medical Research Radiological Centre of the Ministry of Health of Russia
- Published
- 2021
4. The Prognostic Value of Post Thyroidectomy 99mTCpertechnetate Thyroid Scan in Patient With Differentiated Thyroid Cancer
- Author
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Aya Khaled Mahmoud, resident doctor
- Published
- 2021
5. Microleakage Study of a Bulk Fill over an Uncured Adhesive System.
- Author
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Pinto, Mariana Vaz, Pires, Salomé, Marto, Carlos Miguel, Amaro, Inês, Coelho, Ana, Sousa, José, Ferreira, Manuel Marques, Botelho, Maria Filomena, Carrilho, Eunice, Abrantes, Ana Margarida, and Paula, Anabela Baptista
- Subjects
ADHESIVES ,RESIN adhesives ,BOND strengths ,RADIOISOTOPES ,EXPERIMENTAL groups - Abstract
This study aimed to evaluate and compare the microleakage of composite resin restorations under a total-etch adhesive system applied with two different techniques, with and without cure. Cavities were made on the buccal surface of twenty-six intact teeth and subsequently restored with bulk-fill flow composite resin (SDR
®® flow+) and conventional resin (Spectra™ ST HV). Two experimental groups were created, one where the total-etch adhesive (Prime & Bond Active® ) was cured and another where the adhesive was not cured before placing the flowable resin. Two control groups were also created, negative and positive. After the restorations were finished the, teeth were submerged in a solution of sodium pertechnetate (99m TcNaO4) for 3 h to evaluate the microleakage. The results showed more infiltration of radioisotopes characterized by the highest total count values of microleakage in group 1 (cured adhesive) and in the positive control. Group 2 (noncured adhesive) and the negative control showed lower values. We therefore considered that these groups were similar since their p-value was less than 0.05, with no statistically significant difference. Group 4 showed a statistically significant increase in relation to group 3 (p = 0.027). We concluded that the method of bulk-fill composite resins with noncured adhesive agents can have a positive effect on the longevity of bond strengths, with reduced microleakage. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
6. SLNB After Nipple Sparing Mastectomy
- Author
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Halil KARA, Principal Investigator
- Published
- 2019
7. Structure and Thermochemistry of Perrhenate Sodalite and Mixed Guest Perrhenate/Pertechnetate Sodalite
- Author
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Pierce, Eric M, Lilova, Kristina, Missimer, David M, Lukens, Wayne W, Wu, Lili, Fitts, Jeffrey, Rawn, Claudia, Huq, Ashfia, Leonard, Donovan N, Eskelsen, Jeremy R, Woodfield, Brian F, Jantzen, Carol M, and Navrotsky, Alexandra
- Subjects
Inorganic Chemistry ,Chemical Sciences ,Organic Chemicals ,Radioactive Waste ,Sodium Pertechnetate Tc 99m ,Technetium ,Environmental Sciences - Abstract
Treatment and immobilization of technetium-99 (99Tc) contained in reprocessed nuclear waste and present in contaminated subsurface systems represents a major environmental challenge. One potential approach to managing this highly mobile and long-lived radionuclide is immobilization into micro- and meso-porous crystalline solids, specifically sodalite. We synthesized and characterized the structure of perrhenate sodalite, Na8[AlSiO4]6(ReO4)2, and the structure of a mixed guest perrhenate/pertechnetate sodalite, Na8[AlSiO4]6(ReO4)2-x(TcO4)x. Perrhenate was used as a chemical analogue for pertechnetate. Bulk analyses of each solid confirm a cubic sodalite-type structure (P4̅3n, No. 218 space group) with rhenium and technetium in the 7+ oxidation state. High-resolution nanometer scale characterization measurements provide first-of-a-kind evidence that the ReO4- anions are distributed in a periodic array in the sample, nanoscale clustering is not observed, and the ReO4- anion occupies the center of the sodalite β-cage in Na8[AlSiO4]6(ReO4)2. We also demonstrate, for the first time, that the TcO4- anion can be incorporated into the sodalite structure. Lastly, thermochemistry measurements for the perrhenate sodalite were used to estimate the thermochemistry of pertechnetate sodalite based on a relationship between ionic potential and the enthalpy and Gibbs free energy of formation for previously measured oxyanion-bearing feldspathoid phases. The results collected in this study suggest that micro- and mesoporous crystalline solids maybe viable candidates for the treatment and immobilization of 99Tc present in reprocessed nuclear waste streams and contaminated subsurface environments.
- Published
- 2017
8. Microleakage Study of a Bulk Fill over an Uncured Adhesive System
- Author
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Mariana Vaz Pinto, Salomé Pires, Carlos Miguel Marto, Inês Amaro, Ana Coelho, José Sousa, Manuel Marques Ferreira, Maria Filomena Botelho, Eunice Carrilho, Ana Margarida Abrantes, and Anabela Baptista Paula
- Subjects
dental leakage ,sodium pertechnetate Tc 99m ,uncured adhesive system ,co-cure ,hybrid layer ,Technology ,Science - Abstract
This study aimed to evaluate and compare the microleakage of composite resin restorations under a total-etch adhesive system applied with two different techniques, with and without cure. Cavities were made on the buccal surface of twenty-six intact teeth and subsequently restored with bulk-fill flow composite resin (SDR®® flow+) and conventional resin (Spectra™ ST HV). Two experimental groups were created, one where the total-etch adhesive (Prime & Bond Active®) was cured and another where the adhesive was not cured before placing the flowable resin. Two control groups were also created, negative and positive. After the restorations were finished the, teeth were submerged in a solution of sodium pertechnetate (99mTcNaO4) for 3 h to evaluate the microleakage. The results showed more infiltration of radioisotopes characterized by the highest total count values of microleakage in group 1 (cured adhesive) and in the positive control. Group 2 (noncured adhesive) and the negative control showed lower values. We therefore considered that these groups were similar since their p-value was less than 0.05, with no statistically significant difference. Group 4 showed a statistically significant increase in relation to group 3 (p = 0.027). We concluded that the method of bulk-fill composite resins with noncured adhesive agents can have a positive effect on the longevity of bond strengths, with reduced microleakage.
- Published
- 2023
- Full Text
- View/download PDF
9. Sodium Pertechnetate (99Tc) Injection Generator: 99mTc From Neutron-activation 99Mo v 99mTc From Fission 99Mo
- Author
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Winnipeg Regional Health Authority and Dr. Sandor J. Demeter, Head, Nuclear Medicine
- Published
- 2017
10. Tc-Pertechnetate Scintigraphy Predicts Successful Postoperative Ablation in Differentiated Thyroid Carcinoma Patients Treated with Low Radioiodine Activities
- Author
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Luca Giovanella, Gaetano Paone, Teresa Ruberto, Luca Ceriani, and Pierpaolo Trimboli
- Subjects
Differentiated thyroid carcinoma ,Radioiodine ,Radionuclide imaging ,Sodium pertechnetate Tc 99m ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
BackgroundPostoperative routine radioiodine (RAI) treatment is currently debated for patients with low-risk differentiated thyroid carcinoma (DTC) patients. If performed, a low 131I activity (i.e., 1 to 2 GBq) is recommended with the aim to ablate thyroid remnant and facilitate subsequent follow-up by thyroglobulin measurement. The purpose of this study was to evaluate the relationship between postsurgical technetium-99m (99mTc)-pertechnetate scintigraphy and the rate of successful remnant ablation after low activity radioiodine ablation in patients with DTC.MethodsEnrolled were 193 patients with low risk DTC who underwent total thyroidectomy and RAI ablation with a fixed 1.1 GBq activity of 131I. 99mTc-pertechnetate scans were done and thyrotropin stimulated thyroglobulin (sTg) levels measured just before ablation. Ablation effectiveness was assessed 6 to 12 months later by sTg measurement, neck ultrasound and diagnostic whole body scan.ResultsA negative 99mTc-perthecnetate scans was the best predictor of successful ablation (P
- Published
- 2019
- Full Text
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11. Evaluation of Microleakage of Nanoparticle-incorporated Cyanoacrylate Root Canal Sealer Using the Radioisotopic Method: An In Vitro Study.
- Author
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Shetty C, Qaiser S, Shetty A, and Shroff R
- Subjects
- Humans, In Vitro Techniques, Cyanoacrylates, Root Canal Obturation methods, Sodium Pertechnetate Tc 99m, Materials Testing, Dental Leakage prevention & control, Root Canal Filling Materials chemistry, Nanoparticles, Microscopy, Confocal, Epoxy Resins
- Abstract
Aim of the Study: The study aimed to assess the microleakage of nanoparticle-based (NPB) cyanoacrylate sealer and epoxy resin-based (ERB) sealer using radioisotope method and confocal laser scanning microscopy (CLSM)., Materials and Methods: A total of 100 single-rooted teeth were collected; specimens were accessed, instrumented, and irrigated, and randomly distributed into 4 groups of 25 samples each: Group I: Positive control, group II: Negative control, group III: Obturated with NPB sealer, and group IV: Obturated with ERB sealer. All samples were immersed in 99mTc pertechnetate solution, for 3 hours after which radioactivity was estimated under a Gamma camera. The radioactivity released by specimens before and after nail varnish removal was statistically analyzed. After 2 weeks, the same samples were used for CLSM analysis. The sealer tubular penetration depth was measured at the deepest level for each group using ZEN lite 2012. Data collected was statistically evaluated., Results: The amount of radioactivity observed at first in group III and group IV was 194.76 and 599.12 units, respectively, with p -value < 0.001, indicating significant interaction, and after nail varnish removal, it was 89.68 and 468.44 units, respectively, with a p -value < 0.001; again, indicating statistical significance. Hence, the radioactivity of NPB sealer was found to be lower than ERB sealer in both cases, indicating better sealing of the former. The photomicrographs show that mean value of dye penetration in NPB sealer in first, second, and third segment from apex was 85.06, 75.73, and 66.09, respectively; while in the case of ERB sealer, those were 597.28, 461.17, and 195.68, respectively; with p -value < 0.001; signifying that NPB sealer exhibited higher resistance to microleakage than ERB sealer., Conclusion: The NPB sealer can become a potential root canal sealer in future endodontics due to superior physiochemical properties attributed to the cyanoacrylate and incorporated nanoparticles., Clinical Significance: The study clinically signifies that we can equally use the radioisotopic method along with confocal method while conducting the microleakage studies. In addition, NPB sealer can be an emerging replacement with better properties than gold standard root canal sealers for clinical use. How to cite this article: Shetty C, Qaiser S, Shetty A, et al . Evaluation of Microleakage of Nanoparticle-incorporated Cyanoacrylate Root Canal Sealer Using the Radioisotopic Method: An In Vitro Study. J Contemp Dent Pract 2024;25(4):335-341.
- Published
- 2024
- Full Text
- View/download PDF
12. Rubidium-82 PET and Tc-99m-MIBI SPET: A Head to Head Comparison
- Published
- 2014
13. The utility of technetium-99m pertechnetate thyroid scintigraphy assessing thyroid/salivary ratio as an alternative to thyroid uptake percentage in evaluation of thyroid function, with establishing normal reference values of both parameters: single Egyptian center study
- Author
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Heba M, Abdelhamed, Mohamed S, Abdo Soliman, Amira A, Mahmoud, Ramadan, Mohamed, Ismail M, Ali, and Shaimaa F, Abdelhai
- Subjects
Reference Values ,Humans ,Technetium ,Egypt ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Radiopharmaceuticals ,Radionuclide Imaging ,Thyroid Diseases ,Sodium Pertechnetate Tc 99m ,Retrospective Studies - Abstract
Management of thyroid disorders depends on accurate clinical assessment, appropriate investigations and radionuclide imaging, which plays an established important role either qualitatively or quantitatively. The aim of this study was to assess the utility of the thyroid/salivary ratio (TSR) as an alternative to technetium-99m (Tc99m) pertechnetate thyroid uptake (TcU) percentage in the evaluation of thyroid function and in the same time to establish reference range for the thyroid uptake of Tc99m-pertechnetate and TSR among Egyptian populations.This retrospective study enrolled 270 patients, out of which 250 with different thyroid disorders and 20 without thyroid diseases, as a control group who all underwent full clinical examination, thyroid function tests and Tc99m pertechnetate thyroid scintigraphy. The TcU percentage and TSR were calculated and then correlated to the thyroid hormonal profile.The normal reference ranges of TcU and TSR were 0.75-3.5% and 1.25-4.8%, respectively. The sensitivity and specificity of TSR to diagnose hyperthyroidism were slightly lower compared with TcU (84.5 and 92.3% vs. 86.2 and 98.3%, respectively) at TSR cutoff value of more than 4.8 and TcU cutoff value of more than 3.5. Meanwhile, they had comparable sensitivity and specificity to diagnose hypothyroidism (86.0 and 93.3% vs. 86.5 and 94.5%) at cutoff values0.75 and1.25, respectively.The current study established a reference range for TcU and TSR in our institution. TSR is comparable to TcU in the evaluation of thyroid function among hyper-and hypothyroid patients and TSR can be used in doubtful cases of mal-thyroid function for confirmation of the diagnosis.
- Published
- 2022
14. Apical Sealing Ability of Two Calcium Silicate-Based Sealers Using a Radioactive Isotope Method: An In Vitro Apexification Model
- Author
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Inês Raquel Pereira, Catarina Carvalho, Siri Paulo, José Pedro Martinho, Ana Sofia Coelho, Anabela Baptista Paula, Carlos Miguel Marto, Eunice Carrilho, Maria Filomena Botelho, Ana Margarida Abrantes, and Manuel Marques Ferreira
- Subjects
apexification ,calcium silicate ,dental leakage ,mineral trioxide aggregate ,sodium pertechnetate Tc 99m ,Technology ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Microscopy ,QH201-278.5 ,Descriptive and experimental mechanics ,QC120-168.85 - Abstract
The aim of this study was to evaluate and compare the sealing ability of two calcium silicate-based sealers (TotalFill BC RRM Fast Set Putty and White ProRoot MTA) when used as apical plugs in immature teeth through nuclear medicine. Single-rooted extracted teeth (n = 34) had their crowns and root tip sectioned to obtain 14 mm long root segments to simulate an in vitro apexification model. Were created two experimental groups, namely MTA (n = 12) and BC (n = 12), and two control groups, PG (positive group, n = 5) and NG (negative group, n = 5). On the 4th day after placing the respective apical plug, the apical portions of the teeth were submerged in a solution of sodium pertechnetate (99mTcNaO4) for 3 h. Statistical analysis showed a significant difference between the MTA group and the controls (p < 0.05). The BC group had a significant difference regarding the negative control (p < 0.001) but showed no statistical significance regarding the positive control (p = 0.168). There was a statistically significant difference (p = 0.009) between the BC group (7335.8 ± 2755.5) and the MTA group (4059.1 ± 1231.1), where the last showed less infiltration. Within the limitations of this study, White ProRoot MTA had a significantly better sealing ability than TotalFill BC RRM Fast Set Putty.
- Published
- 2021
- Full Text
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15. Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas
- Author
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Annick Van den Bruel, Jacqueline Bijnens, Helena Van Haecke, Vincent Vander Poorten, Catherine Dick, Tom Vauterin, and Frank De Geeter
- Subjects
Adenoma ,Parathyroid Neoplasms ,Multidisciplinary ,Positron Emission Tomography Computed Tomography ,Hyperparathyroidism ,Humans ,Retrospective Studies ,Sodium Pertechnetate Tc 99m - Abstract
We retrospectively evaluated how accurately preoperative imaging localizes parathyroid adenoma in superior versus inferior parathyroids. Over 6 years, 104 patients with primary hyperparathyroidism underwent parathyroid surgery in a single centre. Of these, 103 underwent ultrasound, 97 [99mTc]pertechnetate/MIBI SPECT/CT and 30 [18F]fluorocholine (FCH) PET/CT. One patient with a unilateral double adenoma was excluded from the analysis. Surgical findings with histopathologic confirmation of adenoma were used as the standard. Ultrasound misjudged 5 of 48 detected lower adenomas as upper, but 14 of 29 upper adenomas as lower (error rate 10 vs 48%, p = 0.0002). The corresponding error rates for [99mTc]pertechnetate/MIBI SPECT/CT were 3 versus 55% (p = 0.000014), and for [18F]FCH PET/CT 17 versus 36% (p = 0.26). Our results suggest that about half of the superior parathyroid adenomas which are detected, are erroneously assigned to the inferior position by both ultrasound and SPECT/CT imaging whereas the opposite mistake is significantly less frequent with ultrasound and SPECT/CT.
- Published
- 2023
16. Sufficiency of a Single Negative Thyroglobulin Standard for Judging the Success of Ablation in Low- and Intermediate-risk Differentiated Thyroid Cancer: A Retrospective Study.
- Author
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Long Y, Jin J, and Zhang W
- Subjects
- Humans, Male, Female, Middle Aged, Retrospective Studies, Adult, Treatment Outcome, Aged, Thyroidectomy methods, Ablation Techniques methods, Young Adult, Risk Factors, Radiopharmaceuticals administration & dosage, Sodium Pertechnetate Tc 99m, Thyroglobulin blood, Thyroid Neoplasms surgery, Thyroid Neoplasms blood, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms pathology, Iodine Radioisotopes therapeutic use, Iodine Radioisotopes administration & dosage
- Abstract
Background: We investigated how reduced successful ablation criteria may be used to evaluate radioiodine remnant ablation in patients with low- and intermediate-differentiated thyroid carcinoma (DTC)., Methods: Overall, 254 low- and intermediate-risk patients with DTC were categorized into three groups (positive, weak, positive, and negative) on the basis of a visual study of thyroid imaging performed before postoperative iodine treatment. Semi-quantitative analysis parameters were incorporated into the positive Tc-99m pertechnetate scanning to further examine the clinical use of thyroid imaging. We investigated the value of successful judgment criteria and the influencing factors of radioiodine ablation. At the same time, the predictive value of thyroglobulin (Tg) for radioiodine treatment and the overall clinical efficacy were assessed., Results: A total of 250 (98.43%) patients were identified as having functional thyroid tissue residue on the Rx-whole-body scan, and 137 (53.94%) patients had positive Tc-99m pertechnetate scans using semi-quantitative analysis. The single Tg standard could not substitute the double standard (χ
2 c =22.042, p <0.001) for patients with residual thyroid weight by a semiquantitative analysis. However, the semi-quantitative analysis revealed no association between 99mTcO4-thyroid scan and ablation treatment using semi-quantitative analysis; only preablation sTg levels were related with success in the multivariate logistic regression analysis, with a cut-off value of 2.88 ng/mL. The pre-ablation stimulated Tg level was also the primary factor of satisfactory response following follow-up with an optimal cut-off of 6.506 ng/mL., Conclusion: Even in low- and intermediate-risk patients with DTC, a single negative Tg standard also requires receiving some restrictions in the evaluation of ablation success and is inadequate. Conventional 99mTcO4 thyroid imaging combined with a quantitative analysis program can improve the clinical practice of single negative Tg standard., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)- Published
- 2024
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17. Menstruation Confounding the Correct Interpretation of 99m Tc-RBC Bleeding Scan.
- Author
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Wang G, Lu X, Wang W, and Yang J
- Subjects
- Female, Adolescent, Humans, Technetium, Radionuclide Imaging, Gastrointestinal Hemorrhage diagnostic imaging, Sodium Pertechnetate Tc 99m, Radiopharmaceuticals, Menstruation, Meckel Diverticulum diagnostic imaging
- Abstract
Abstract: 99m Tc-RBC bleeding scan in a 17-year-old adolescent girl showed an increased focal activity in the pelvis. However, SPECT/CT showed that this activity was located in the uterus, which was considered a normal variant considering that the patient was in her fourth day of the menstrual period. Subsequent 99m TcO 4- Meckel scan showed the typical characteristic of ectopic gastric mucosa in the small bowel. Postsurgical pathology confirmed the diagnosis of ectopic gastric mucosa. This case suggested the menstrual period uterus should be included as differential diagnosis of 99m Tc-RBC scan., Competing Interests: Conflicts of interest and sources of funding: All authors declared that there were no conflicts of interest and sources of funding. W.W. was supported by the National Natural Science Foundation of China (no. 82102088). J.Y. was supported by the National Natural Science Foundation of China (no. 82272034, 82001860, 81971642, 82001861)., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
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18. Retrospective Diagnosis of Ca Thyroid on Thyroid Pertechnetate Scan -A part of Routine Post Thyroidectomy Work up For Nontoxic Multi Nodular Goiter.
- Author
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Mir KB, Ammar A, Batool S, Ahmad N, Saeed A, Faheem M, and Hassan A
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- Humans, Thyroidectomy, Sodium Pertechnetate Tc 99m, Retrospective Studies, Biopsy, Fine-Needle, Goiter, Nodular diagnostic imaging, Goiter, Nodular surgery, Thyroid Neoplasms diagnosis
- Abstract
Unsuspected thyroid cancer can be detected in multinodular goiter (MNG) where the risk of malignancy is 7-9%. Fine needle aspiration (FNAc) is performed in case of suspicious findings on ultrasound. With benign FNAC results there is no need for surgery unless the patient has pressure symptoms or cosmetic concerns, but the risk of overlooked malignancy is always present. We present the case of a patient with unexpected detection of papillary thyroid cancer on thyroid scan.
- Published
- 2024
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19. Pitfalls of DualTracer 99m-Technetium (Tc) Pertechnetate and Sestamibi Scintigraphy before Parathyroidectomy: Between Primary-Hyperparathyroidism-Associated Parathyroid Tumour and Ectopic Thyroid Tissue.
- Author
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Carsote M, Stanciu M, Popa FL, Sima OC, Petrova E, Cucu AP, and Nistor C
- Subjects
- Adult, Humans, Female, Parathyroidectomy methods, Sodium Pertechnetate Tc 99m, Technetium, Sensitivity and Specificity, Radiopharmaceuticals, Radionuclide Imaging, Technetium Tc 99m Sestamibi, Organotechnetium Compounds, Parathyroid Neoplasms complications, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms surgery, Hyperparathyroidism diagnostic imaging, Hyperparathyroidism surgery, Thyroid Diseases, Thyroid Dysgenesis surgery
- Abstract
Diagnosis of primary hyperparathyroidism (PHP) is based on blood assessments in terms of synchronous high calcium and PTH (parathormone), but further management, particularly parathyroid surgery that provides the disease cure in 95-99% of cases, requires an adequate localisation of the parathyroid tumour/tumours as the originating source, with ultrasound and 99m-Technetium (99m-Tc) sestamibi scintigraphy being the most widely used. We aimed to introduce an adult female case diagnosed with PHP displaying unexpected intra-operatory findings (ectopic thyroid tissue) in relation to concordant pre-operatory imaging modalities (ultrasound + dual-phase 99m-Tc pertechnetate and sestamibi scintigraphy + computed tomography) that indicated bilateral inferior parathyroid tumours. A sudden drop in PTH following the removal of the first tumour was the clue for performing an extemporaneous exam for the second mass that turned out to be non-malignant ectopic thyroid tissue. We overviewed some major aspects starting from this case in point: the potential pitfalls of pre-operatory imaging in PHP; the concordance/discordance of pre-parathyroidectomy localisation modalities; the need of using an additional intra-operatory procedure; and the clues of providing a distinction between pathological parathyroids and thyroid tissue. This was a case of adult PHP, whereas triple localisation methods were used before parathyroidectomy, showing concordant results; however, the second parathyroid adenoma was a false positive image and an ectopic thyroid tissue was confirmed. The pre-operatory index of suspicion was non-existent in this patient. Hybrid imaging modalities are most probably required if both thyroid and parathyroid anomalies are suspected, but, essentially, awareness of the potential pitfalls is mandatory from the endocrine and surgical perspectives. Current gaps in imaging knowledge to guide us in this area are expected to be solved by the significant progress in functional imaging modalities. However, the act of surgery, including the decision of a PTH assay or extemporaneous exam (as seen in our case), represents the key to a successful removal procedure. Moreover, many parathyroid surgeons may currently perform 4-gland exploration routinely, precisely to avoid the shortcomings of preoperative localisation.
- Published
- 2023
- Full Text
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20. Thyroid Accumulation of 99m Tc-DTPA in Graves Disease.
- Author
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Zhong P, Yang J, Wang Y, Wei L, and Chen L
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- Female, Humans, Adult, Radiopharmaceuticals, Tomography, X-Ray Computed, Technetium, Sodium Pertechnetate Tc 99m, Technetium Tc 99m Pentetate, Graves Disease diagnostic imaging
- Abstract
Abstract: 99m Tc-DTPA dynamic renal scintigraphy for evaluating glomerular filtration rate was performed in a 29-year-old woman with hyperuricemia and Graves disease. Subsequently, 99m Tc-DTPA orbital scintigraphy was conducted to determine the activity of Graves ophthalmopathy. Thyroid accumulation of 99m Tc-DTPA was incidentally identified. This should be cautiously distinguished from 99m Tc-pertechnetate uptake, considering that the salivary glands, oral cavity, and stomach were not visualized. Our case demonstrates that augmentation of blood supply, enhancement of capillary permeability, and accumulation of inflammatory exudate may be involved in the pathological process of Graves disease., Competing Interests: Conflicts of interest and sources of funding: none declared., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
- Full Text
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21. 99mTc-Pertechnetate Scintigraphy Predicts Successful Postoperative Ablation in Differentiated Thyroid Carcinoma Patients Treated with Low Radioiodine Activities.
- Author
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Giovanella, Luca, Paone, Gaetano, Ruberto, Teresa, Ceriani, Luca, and Trimboli, Pierpaolo
- Subjects
- *
THYROID cancer , *IODINE isotopes , *THYROIDECTOMY , *ULTRASONIC imaging , *WHOLE body imaging , *DIAGNOSTIC ultrasonic imaging , *RADIONUCLIDE imaging - Abstract
Background: Postoperative routine radioiodine (RAI) treatment is currently debated for patients with low-risk differentiated thyroid carcinoma (DTC) patients. If performed, a low 131I activity (i.e., 1 to 2 GBq) is recommended with the aim to ablate thyroid remnant and facilitate subsequent follow-up by thyroglobulin measurement. The purpose of this study was to evaluate the relationship between postsurgical technetium-99m (99mTc)-pertechnetate scintigraphy and the rate of successful remnant ablation after low activity radioiodine ablation in patients with DTC. Methods: Enrolled were 193 patients with low risk DTC who underwent total thyroidectomy and RAI ablation with a fixed 1.1 GBq activity of 131I. 99mTc-pertechnetate scans were done and thyrotropin stimulated thyroglobulin (sTg) levels measured just before ablation. Ablation effectiveness was assessed 6 to 12 months later by sTg measurement, neck ultrasound and diagnostic whole body scan. Results: A negative 99mTc-perthecnetate scans was the best predictor of successful ablation (P<0.001) followed by preablative sTg levels <0.8 ng/mL (P=0.008) and 99mTc-pertechnetate uptake rate values <0.9% (P=0.065). Neither sex nor age of the patient at the time of ablation or tumor histology and size showed a significant association with the rate of successful ablation. Conclusion: The 99mTc-pertechnetate scintigraphy is a simple and feasible tool to predict effectiveness of low activity 131I thyroid to ablate thyroid remnants in patients with DTC. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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22. 99m-Technetium-pertechnetate- and 99m-Technetium-sestamibi-scintigraphy for visualization of hypofunctioning thyroid tissue and staging in a dog with thyroid carcinoma
- Author
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Hannah, Altmann, Yi, Cui, Manfred, Henrich, Sebastian, Schaub, Cetina, Thiel, Andreas, Moritz, Richard, Bauer, and Natali, Bauer
- Subjects
Technetium Tc 99m Sestamibi ,Dogs ,Adenocarcinoma, Follicular ,Humans ,Animals ,Technetium ,Female ,Thyroid Nodule ,Thyroid Neoplasms ,Dog Diseases ,Radionuclide Imaging ,Sodium Pertechnetate Tc 99m - Abstract
A 10-year-old female mixed breed dog was presented for thyroid scintigraphy due to a cervical mass. Apart from 99m-Technetium-pertechnetate (Tc-pertechnetate) scintigraphy, a second scintigraphy using 99m-Technetium sestamibi (Tc-MIBI) was performed because of additional hypothyroidism suspective for a "cold" nodule and as screening for metastases.Twenty minutes following intravenous injection of 38 MBq Tc-pertechnetate, a "hot" cervical as well as a "hot" intrathoracal nodule were seen with an uptake of 8.40 and 0.25 %, respectively. The second scintigraphy was performed 20 minutes after intravenous injection of 364 MBq Tc-MIBI and 70 minutes following the first. After subtraction of pertechnetate activity and decay correction, both nodules showed an uptake of 0.99 and 0.03 %. Additionally, both thyroid lobes were visible in the thyroid loge with a weak MIBI-uptake. For both lesions, the ratio Tc-uptake/Tc-MIBI-uptake was 8.48 and 8.33, respectively.Following the extirpation of the cervical mass, histopathology revealed atrophied healthy thyroid tissue almost completely displaced by a well-differentiated follicular thyroid carcinoma.This case report describes performance, utility and calculative correction of consecutive pertechnetate- and MIBI-scan, that enable a visualization of hypofunctional thyroid tissue.Therefore and because of their similar MIBI metabolic activity, both nodules were considered to be dystopic tissue/metastases so that this dog had to be classified as prognostically less favorable WHO stabe IV. Different from human patients, both scintigraphies should be performed shortly after another in dogs in order to avoid the necessity of a second anesthetic procedure. A reliable qualitative/visual evaluation of the MIBI-scan is therefore not possible, so that a quantitative assessment using the uptake after calculative correction of the pertechnetate activity is recommended.Eine 10-jährige Mischlingshündin wurde aufgrund einer zervikalen Umfangsvermehrung zur Schilddrüsen-Szintigrafie vorgestellt.Aufgrund einer zusätzlichen Hypothyreose, die einen „kalten“ Knoten vermuten ließ, und zur Metastasensuche, erfolgte neben der 99m-Technetium-Pertechnetat (Tc-Pertechnetat)-Szintigrafie eine zweite Szintigrafie mit 99m-Technetium-Sestamibi (Tc-MIBI).Zwanzig Minuten nach intravenöser Gabe von 38 MBq Tc-Pertechnetat waren ein „heißer“ zervikaler und ein intrathorakaler Knoten mit einem „Uptake“ von 8,40 und 0,25 % sichtbar. In der zweiten Szintigrafie 20 Minuten nach intravenöser Gabe von 364 MBq Tc-MIBI und 70 Minuten nach der ersten Szintigrafie zeigten die Knoten nach Abzug der Pertechnetat-Aktivität und Zerfallskorrektur einen „Uptake“ von 0,99 und 0,03 %. Zudem stellten sich in der Schilddrüsenloge beide Schilddrüsenlappen mit einer geringen Tc-MIBI-Aufnahme dar. Das Verhältnis Tc-„Uptake“/Tc-MIBI-„Uptake“ betrug für beide Läsionen 8,48 bzw. 8,33.Nach Exstirpation des zervikalen Tumors ergab die histopathologische Untersuchung atrophisches Schilddrüsengewebe, das von einem expansiv wachsenden gut differenzierten follikulären Schilddrüsenkarzinom fast vollständig verdrängt wurde.Dieser Fallbericht beschreibt Durchführung, Nutzen und rechnerische Korrektur einer aufeinanderfolgenden Pertechnetat- und MIBI-Szintigrafie, die eine Darstellung von hypofunktionellem Schilddrüsengewebe ermöglichte. Die beiden heißen Knoten waren daher und aufgrund ihrer gleichen MIBI-Stoffwechselaktivität als dystopes Gewebe/Metastasen zu werten, wodurch die Hündin in das prognostisch ungünstigere WHO-Stadium IV klassifiziert werden musste. Anders als beim Menschen sollten beim Hund zur Vermeidung einer erneuten Narkose beide Szintigrafien kurz hintereinander durchgeführt werden. Eine qualitative/visuelle Beurteilung des MIBI-Szintigramms ist daher nicht sicher möglich, sodass eine quantitative Beurteilung über den „Uptake“ nach rechnerischer Korrektur der Pertechnetat-Aktivität erfolgen muss.
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- 2022
23. Primary osteosarcoma of the thyroid gland.
- Author
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Nitzsche, EU, Seeger, LL, Klosa, B, Freudenberg, N, and Moser, EA
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Pediatric ,Rare Diseases ,Aged ,Diphosphonates ,Female ,Humans ,Neoplasm Recurrence ,Local ,Organotechnetium Compounds ,Osteosarcoma ,Radionuclide Imaging ,Sodium Pertechnetate Tc 99m ,Thyroid Neoplasms ,Tomography ,X-Ray Computed ,Ultrasonography ,Clinical Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
Primary extraosseous osteosarcoma of the thyroid gland is a rare tumor which is associated with a poor prognosis. In this report, we discuss such a tumor and its recurrence in a 78-yr-old female with multinodular goiter, focusing on the imaging evaluation of this unusual tumor.
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- 1992
24. Dosimetric evaluation of 123 I (Iodide) and 99m Tc (Pertechnetate) in the thyroid of neonates using Cristy-Eckerman and Segars anatomical representations.
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Vasquez-Arteaga M, Vega-Carrillo HR, Acuña-Peralta L, Rodriguez Nomura H, Vasquez-Silva M, and Flores Urquiaga H
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- Humans, Infant, Newborn, Iodides, Radiopharmaceuticals, Iodine Radioisotopes, Thyroid Gland diagnostic imaging, Sodium Pertechnetate Tc 99m
- Abstract
Using the MIRD formalism, and the Cristy-Eckeman and Segars anthropomorphic representations, the absorbed dose in the thyroid of newborns, was calculated when
123 I (iodide) and99m Tc (pertechnetate) are used during the diagnostic procedures. The dose results will allow exploring the dosimetric impact generated by the use of these radiopharmaceutical compounds and the use of two representations. Regardless the radiopharmaceutical compound and the anthropomorphic representation is the thyroid self-dose is the greatest, due to electrons emitted during the123 I and99m Tc radioisotopes. The relative difference in total dose to the newborn thyroid gland using the Cristy-Eckerman and Segars anthropomorphic representations for the compounds123 I(iodide) and99m Tc(pertechnetate) is 1.82%, and 1.33%, respectively. Regardless of the radiopharmaceutical compound, the replacement of Cristy-Eckerman by Segars phantom does not reflect significant changes in the estimated absorbed dose to the newborn thyroid. Regardless of the anthropomorphic representation, the lowest absorbed dose in newborn's thyroid is obtained when using99m Tc (pertechnetate) is used due to the residence times., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)- Published
- 2023
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25. The Effectiveness of Ionized Water as a Radiodecontaminant for 99m Tc-Pertechnetate and 131 I.
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Rillorta MAP and Espiritu AJ
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- Humans, Stainless Steel, Iodine Radioisotopes, Sodium Pertechnetate Tc 99m, Detergents
- Abstract
Immediate and complete decontamination procedures are essential to restore the functionality, precision, accuracy, and safety of tests done within the nuclear medicine facility. Decontamination is a simple procedure that, if performed correctly, effectively reduces exposure brought about by spills. The determination of a suitable radiodecontaminant may be beneficial in decontaminating patient beds, collimators, probes, and machines. Methods: Two surface types (i.e., stainless steel and vinyl) were contaminated with a predetermined activity of
99m TcO4 and131 I. After air drying, static images of the contaminated surfaces were obtained using a γ-camera to determine the activity counts on each surface before and after decontamination procedures. Different decontaminant contact times (i.e., 5, 10, and 15 min) were used for each decontaminant (i.e., ionized water, 10% bleach, detergent solution, a negative control [no treatment], and a positive control [a commercial radiodecontaminant]). Differences between the effectiveness of ionized water and the other decontaminants against99m TcO4 and131 I at different contact times were measured, and the mean percentage activity removed (%AR) was compared using 2-way ANOVA at the 0.05 level of significance. Results:99m TcO4 and131 I contaminants had %ARs of greater than 80% after 5 min of contact time for ionized water and the other decontaminants. At 15 min contact time, ionized water was not as effective as the other decontaminating agents for131 I on vinyl surfaces. There was no significant interaction between the effects of the decontaminants (%AR) and the contact times with stainless steel and vinyl for either99m TcO4 or131 I. Conclusion: For99m TcO4 and131 I on stainless steel surfaces, ionized water is an effective decontaminant at contact times of 5, 10, and 15 min. For99m TcO4 on vinyl surfaces, ionized water is also an effective decontaminant at contact times of 5, 10, and 15 min. For131 I on vinyl surfaces, ionized water is as effective as 10% bleach, detergent solution, and a commercial radiodecontaminant at contact times of 5 and 10 min., (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)- Published
- 2023
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26. Patient Preparation with Esomeprazole Is Comparable to Ranitidine in Meckel Diverticulum Scintigraphy.
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Ververs TF, Lobbezoo AH, Hobbelink MG, and Braat AJ
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- Humans, Esomeprazole, Sodium Pertechnetate Tc 99m, Proton Pump Inhibitors, Radiopharmaceuticals, Radionuclide Imaging, Technetium, Ranitidine, Meckel Diverticulum diagnostic imaging
- Abstract
To localize ectopic gastric mucosa in patients with unexplained gastrointestinal bleeding and diagnose a Meckel diverticulum,
99m Tc-pertechnetate imaging is the standard procedure. H2 inhibitor pretreatment enhances the sensitivity of the scan by reducing washout of99m Tc activity from the intestinal lumen. We aim to provide evidence of the effectiveness of the proton pump inhibitor esomeprazole as an ideal substitute for ranitidine. Methods: The scan quality for 142 patients who underwent a Meckel scan during a period of 10 y was evaluated. The patients were pretreated with ranitidine orally or intravenously before a switch to a proton pump inhibitor after ranitidine was no longer available. Good scan quality was characterized by the absence of99m Tc-pertechnetate activity in the gastrointestinal lumen. The effectiveness of esomeprazole to diminish99m Tc-pertechnetate release was compared with the standard treatment using ranitidine. Results: Pretreatment with intravenous esomeprazole resulted in 48% of scans with no99m Tc-pertechnetate release, 17% with release either in the intestine or in the duodenum, and 35% with99m Tc-pertechnetate activity both in the intestine and in the duodenum. Evaluation of scans obtained after oral ranitidine and intravenous ranitidine showed absence of activity in both intestine and duodenum in 16% and 23% of the cases, respectively. The indicated time to administer esomeprazole before starting the scan procedure was 30 min, but a delay of 15 min did not negatively influence the scan quality. Conclusion: This study confirms that esomeprazole, 40 mg, when administered intravenously 30 min before a Meckel scan, enhances the scan quality comparably to ranitidine. This procedure can be incorporated into protocols., (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)- Published
- 2023
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27. Absorption rate of subcutaneously infused fluid in ill multimorbid older patients
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Mathias Brix Danielsen, Lars Jødal, Johannes Riis, Jesper Scott Karmisholt, Óskar Valdórsson, Martin Gronbech Jørgensen, and Stig Andersen
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Aged, 80 and over ,Multidisciplinary ,Humans ,Technetium ,Infusions, Parenteral ,Hypodermoclysis ,Aged ,Sodium Pertechnetate Tc 99m - Abstract
Background Subcutaneous (SC) hydration is a valuable method for treating dehydration in the very old patients. Data are absent on the absorption rate, and the availability of SC infused fluid in the circulation in this group of patients where SC hydration is particularly relevant. Methods We performed an explorative study on ill very old (range 78–84 years old) geriatric patients with comorbidities who received an SC infusion of 235 ml isotonic saline containing a technetium-99m pertechnetate tracer. The activity over the infusion site was measured using a gamma detector to assess the absorption rate from the SC space. The activity was measured initially every 5 minutes, with intervals extended gradually to 15 minutes. Activity in blood samples and the thyroid gland was measured to determine the rate of availability in the circulation. Results Six patients were included. The mean age was 81 years (SD 2.1), the number of comorbidities was 4.6 (SD 1.3), and the Tilburg frailty indicator was 3.8 (SD 2.4). When the infusion was completed after 60 minutes, 53% (95% CI 50–56%) of the infused fluid was absorbed from the SC space, with 88% (95% CI 86–90%) absorbed one hour later. The absorption rate from the SC space right after the completion of the infusion was 127 ml/h (95% CI 90–164 ml/h). The appearance of the fluid into the blood and the thyroid gland verified the transfer from SC to circulation. Conclusion This first explorative study of absorption of SC infused fluid in the very old found an acceptable amount of fluid absorbed from the SC space into the circulation one hour after infusion had ended. Results are uniform but should be interpreted cautiously due to the low sample size. Trial registration ClinicalTrials.gov Identifier: NCT04536324.
- Published
- 2022
28. Distribution of Functional Status of Thyroid Nodules and Malignancy Rates of Hyperfunctioning and Hypofunctioning Thyroid Nodules in Germany
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Schenke, Simone Agnes, Kreissl, Michael C., Grunert, Michael, Hach, Anja, Haghghi, Sarvar, Kandror, Tatjana, Peppert, Eckhard, Rosenbaum-Krumme, Sandra, Ruhlmann, Verena, Stahl, Alexander, Wanjura, Dieter, Zaplatnikov, Konstantin, Zimny, Michael, Gilman, Elena, Herrmann, Ken, and Görges, Rainer
- Subjects
Adult ,Aged, 80 and over ,Male ,Adolescent ,Medizin ,General Medicine ,Middle Aged ,Iodine Radioisotopes ,Young Adult ,Functional Status ,Naphthalenesulfonates ,Germany ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Thyroid Nodule ,Radionuclide Imaging ,Aged ,Sodium Pertechnetate Tc 99m - Abstract
Aim Thyroid scintigraphy enables the depiction of the functional status of thyroid nodules (TNs) with both, 99mTc-pertechnetate and 123Iodine. The functional status is relevant for diagnostic procedures for the differentiation of benign and malignant TNs. The aim of this study was to examine the current frequencies of hyper-, hypo- and isofunctioning TNs in Germany and to estimate the risk of malignancy with regard to functional status. Methods In 11 study centers, a minimum of 100 nodules per center were consecutively enrolled between July 2019 and April 2020. Inclusion criteria were: newly diagnosed nodule, nodule’ size of 10 mm or more, thyroid scintigraphy. Exclusion criteria were: completely cystic TNs, patients with prior radioiodine therapy or thyroid surgery. The risk of malignancy was estimated for hyper- and hypofunctioning TNs. Results Overall, 849 patients (72 % women) with 1262 TNs were included. Patients’ age ranged from 18 to 90 years. Most TNs were hypofunctioning (n=535, 42%) followed by isofunctioning TNs (n=488, 39%) and hyperfunctioning TNs (n=239, 19%). When only TNs with a maximum size of 2 cm or more were considered the rate of hyperfunctioning and hypofunctioning TNs increased (to 27% and 49%) while isofunctioning TNs decreased. Only one of all hyperfunctioning TNs was malignant. In hypofunctioning nodules, the malignancy rate was estimated at 10%. Conclusion In Germany, the proportion of hyperfunctioning TNs is approximately 20% and increases in larger TNs to up to 27%. Due to the low risk of malignancy in hyperfunctioning TNs, no further procedures to rule out malignancy are necessary. The risk of malignancy of hypofunctioning TNs is significantly higher. Thus, a thyroid scintigraphy is a useful diagnostic tool in Germany.
- Published
- 2022
29. Synchronous Metastatic Medullary Thyroid Carcinoma and Paraesophageal Parathyroid Adenoma Detected on 18 F-Ethylcholine PET/US Fusion Imaging
- Author
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Martin Freesmeyer, Ulrich A. Müller, Matthias Männel, Gabriele Mtuka-Pardon, and Philipp Seifert
- Subjects
Adenoma ,Aged, 80 and over ,Calcitonin ,Technetium Tc 99m Sestamibi ,General Medicine ,Carcinoma, Neuroendocrine ,Choline ,Parathyroid Glands ,Parathyroid Neoplasms ,Parathyroid Hormone ,Positron Emission Tomography Computed Tomography ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Thyroid Neoplasms ,Radiopharmaceuticals ,Sodium Pertechnetate Tc 99m - Abstract
An 80-year-old woman with osteoporosis without fractures was referred with asymptomatic primary hyperparathyroidism and elevated calcitonin level. Ultrasound, 99m Tc-pertechnetate scintigraphy, 99m Tc-MIBI scintigraphy, and CT revealed a suspicious thyroid nodule and enlarged submandibular lymph nodes. However, no parathyroid adenoma was depictable. 18 F-choline PET/CT showed increased uptake of the proximal esophagus, but neither CT nor US revealed a parathyroid lesion, and only 18 F-choline PET/US fusion imaging confirmed a paraesophageal parathyroid adenoma. Resection of both medullary thyroid carcinoma and ectopic parathyroid adenoma through a single cervicotomy was conducted (thyroidectomy, neck dissection, extirpation of parathyroid adenoma); parathyroid hormone and calcitonin dropped to normal. Multiple endocrine neoplasia IIa syndrome was suspected.
- Published
- 2022
30. Radioiodine treatment of hyperthyroidism in cats: results of 165 cats treated by an individualised dosing algorithm in Spain
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Pilar Xifra, Sara I Serrano, and Mark E Peterson
- Subjects
Iodine Radioisotopes ,Thyroxine ,Hypothyroidism ,Spain ,Azotemia ,Cats ,Animals ,Thyrotropin ,Small Animals ,Cat Diseases ,Hyperthyroidism ,Algorithms ,Sodium Pertechnetate Tc 99m - Abstract
Objectives Although radioiodine (131I) is the treatment of choice for feline hyperthyroidism, 131I-dosing protocols commonly induce iatrogenic hypothyroidism and expose azotaemia. A recently reported patient-specific 131I dosing algorithm minimised the risk of 131I-induced hypothyroidism and azotaemia, while maintaining high cure rates. The aim of the study was to report results of 131I treatment in a European population of hyperthyroid cats using this patient-specific dosing algorithm. Methods This prospective case series (before-and-after study) evaluated 165 hyperthyroid cats referred for 131I treatment. All cats had serum concentrations of thyroxine (T4), triiodothyronine (T3) and thyroid-stimulating hormone (TSH) measured (off methimazole ⩾1 week). Thyroid volume and percentage uptake of 99mTc-pertechnetate (TcTU) were determined using thyroid scintigraphy. An initial 131I dose was calculated by averaging dose scores for T4/T3 concentrations, thyroid volume and TcTU; 70% of that composite dose was then administered. Twenty-four hours later, percentage 131I uptake was measured, and additional 131I administered as needed to deliver an adequate radiation dose to the thyroid tumour(s). Serum concentrations of T4, TSH and creatinine were determined 6–12 months later. Results Median calculated 131I dose was 2.15 mCi (range 1.2–7.5), with only 51 (30.9%) receiving ⩾2.5 mCi. Of 165 cats, 124 (75.2%) became euthyroid, seven (4.2%) became overtly hypothyroid, 27 (16.4%) became subclinically hypothyroid and seven (4.2%) remained hyperthyroid. A higher proportion of overtly (85.7%) and subclinically (26.9%) hypothyroid cats developed azotaemia than euthyroid cats (13.6%; P = 0.0002). Hypothyroid cats were older ( P = 0.016) and more likely to have detectable TSH concentrations ( P = 0.025) and symmetrical bilateral distribution of 99mTc-pertechnetate uptake ( P = 0.0002), whereas persistently hyperthyroid cats had higher severity scores ( P = 0.012). Conclusions and relevance Our results confirm that 131I dosing with this new algorithm results in high cure rates, with a lowered prevalence of 131I-induced overt hypothyroidism and azotaemia. Age, serum TSH concentrations, bilateral, symmetrical uptake and severity score help predict outcome.
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- 2022
31. Towards Anion Recognition and Precipitation with Water-Soluble 1,2,4-Selenodiazolium Salts: Combined Structural and Theoretical Study
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Alexey A. Artemjev, Anton P. Novikov, Gleb M. Burkin, Alexander A. Sapronov, Alexey S. Kubasov, Valentine G. Nenajdenko, Victor N. Khrustalev, Alexander V. Borisov, Anatoly A. Kirichuk, Andreii S. Kritchenkov, Rosa M. Gomila, Antonio Frontera, and Alexander G. Tskhovrebov
- Subjects
Anions ,Organic Chemistry ,Water ,General Medicine ,Models, Theoretical ,Catalysis ,Computer Science Applications ,Inorganic Chemistry ,Cations ,Trifluoroacetic Acid ,Salts ,Physical and Theoretical Chemistry ,selenodiazoles ,non-covalent interactions ,chalcogen bonding ,anion recognition ,rhenium ,technetium ,Molecular Biology ,Spectroscopy ,Sodium Pertechnetate Tc 99m - Abstract
The synthesis and structural characterization of a series of supramolecular complexes of bicyclic cationic pyridine-fused 1,2,4-selenodiazoles with various anions is reported. The binding of trifluoroacetate, tetrachloroaurate, tetraphenylborate, perrhenate, and pertechnetate anions in the solid state is regarded. All the anions interact with selenodiazolium cations exclusively via a pair of “chelating” Se⋯O and H⋯O non-covalent interactions, which make them an attractive, novel, non-classical supramolecular recognition unit or a synthon. Trifluoroacetate salts were conveniently generated via novel oxidation reaction of 2,2′-dipyridyl diselenide with bis(trifluoroacetoxy)iodo)benzene in the presence of corresponding nitriles. Isolation and structural characterization of transient 2-pyridylselenyl trifluoroacetate was achieved. X-ray analysis has demonstrated that the latter forms dimers in the solid state featuring very short and strong Se⋯O and Se⋯N ChB contacts. 1,2,4-Selenodiazolium trifluoroacetates or halides show good solubility in water. In contrast, (AuCl4)−, (ReO4)−, or (TcO4)− derivatives immediately precipitate from aqueous solutions. Structural features of these supramolecular complexes in the solid state are discussed. The nature and energies of the non-covalent interactions in novel assembles were studied by the theoretical methods. To the best of our knowledge, this is the first study that regards perrhenate and pertechnetate as acceptors in ChB interactions. The results presented here will be useful for further developments in anion recognition and precipitation involving cationic 1,2,4-selenodiazoles.
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- 2022
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32. Organ-level internal dosimetry for intra-hepatic-arterial administration of
- Author
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S Cheenu, Kappadath and Benjamin P, Lopez
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Adult ,Male ,Tomography, Emission-Computed, Single-Photon ,Liver Neoplasms ,Embolization, Therapeutic ,Microspheres ,Albumins ,Humans ,Female ,Tissue Distribution ,Yttrium Radioisotopes ,Radiopharmaceuticals ,Technetium Tc 99m Aggregated Albumin ,Retrospective Studies ,Sodium Pertechnetate Tc 99m - Abstract
There are no published data on organ doses following intra-hepatic-arterial administration ofThe potential in vivo biodistributions for IHAFor Liver-Only MAA, the liver as source organ received the highest dose at 98.6 and 126 mGy/GBq for the adult male and adult female phantoms, respectively; all remaining organs received 27 and 32 mGy/GBq. For Intravenous MAA, the lung as source organ received the highest dose at 66 and 97 mGy/GBq; all remaining organs received 16 and 21 mGy/GBq. The organ with the highest dose for Intravenous Pertechnetate was the upper-large-intestinal wall at 56 and 73 mGy/GBq; all remaining organs received 26 and 34 mGy/GBq. The liver and lung doses for the maximum-dose scenario with 5 mCi (185 MBq)Organ dose estimates following IHA
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- 2022
33. Quantitative salivary gland SPECT/CT using deep convolutional neural networks
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Junyoung Park, Jae Sung Lee, Dongkyu Oh, Jeong Hee Han, Won Woo Lee, and Hyun Gee Ryoo
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Adult ,Male ,Single Photon Emission Computed Tomography Computed Tomography ,Pertechnetate ,Science ,Automated segmentation ,Convolutional neural network ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Deep Learning ,stomatognathic system ,Operating time ,Image Processing, Computer-Assisted ,Medicine ,Humans ,Parotid Gland ,Oral diseases ,Segmentation ,Thyroid Neoplasms ,Aged ,Sodium Pertechnetate Tc 99m ,Salivary Gland Calculi ,Multidisciplinary ,Salivary gland ,medicine.diagnostic_test ,business.industry ,Diagnostic markers ,Middle Aged ,Translational research ,Salivary Gland Neoplasms ,medicine.anatomical_structure ,chemistry ,030220 oncology & carcinogenesis ,Automatic segmentation ,Feasibility Studies ,Female ,Neural Networks, Computer ,Radiopharmaceuticals ,Nuclear medicine ,business ,Emission computed tomography - Abstract
Quantitative single-photon emission computed tomography/computed tomography (SPECT/CT) using Tc-99m pertechnetate aids in evaluating salivary gland function. However, gland segmentation and quantitation of gland uptake is challenging. We develop a salivary gland SPECT/CT with automated segmentation using a deep convolutional neural network (CNN). The protocol comprises SPECT/CT at 20 min, sialagogue stimulation, and SPECT at 40 min post-injection of Tc-99m pertechnetate (555 MBq). The 40-min SPECT was reconstructed using the 20-min CT after misregistration correction. Manual salivary gland segmentation for %injected dose (%ID) by human experts proved highly reproducible, but took 15 min per scan. An automatic salivary segmentation method was developed using a modified 3D U-Net for end-to-end learning from the human experts (n = 333). The automatic segmentation performed comparably with human experts in voxel-wise comparison (mean Dice similarity coefficient of 0.81 for parotid and 0.79 for submandibular, respectively) and gland %ID correlation (R2 = 0.93 parotid, R2 = 0.95 submandibular) with an operating time less than 1 min. The algorithm generated results that were comparable to the reference data. In conclusion, with the aid of a CNN, we developed a quantitative salivary gland SPECT/CT protocol feasible for clinical applications. The method saves analysis time and manual effort while reducing patients’ radiation exposure.
- Published
- 2021
34. Assessment of normal reference values for thyroid uptake of technetium-99m pertechnetate in a Saudi population
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Moeber M Mahzari, Awad Alshahrani, Shah Pervez Numani, Gulam M. Syed, Altaf H. Khan, Abdulaziz Alnaim, and Faisal Alanazi
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Male ,endocrine system diseases ,Pertechnetate ,Nuclear imaging ,Population ,Saudi Arabia ,Thyroid Gland ,030209 endocrinology & metabolism ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Reference Values ,Humans ,Medicine ,education ,Retrospective Studies ,Sodium Pertechnetate Tc 99m ,Technetium 99m pertechnetate ,Thyroid uptake ,education.field_of_study ,business.industry ,Thyroid ,Technetium ,General Medicine ,Cross-Sectional Studies ,medicine.anatomical_structure ,chemistry ,Reference values ,Original Article ,Female ,Radiopharmaceuticals ,business ,Nuclear medicine - Abstract
BACKGROUND: Thyrotoxicosis is a common medical problem. Thyroid nuclear imaging with either I 123 or technetium-99m (Tc-99m) pertechnetate are used to determine the cause. Although I 123 has been the standard technique, Tc-99m pertechnetate is now commonly used, acceptable and easier to perform. The commonly used normal value of Tc-99m pertechnetate is 1–4%, but lower normal values have been reported in different populations. OBJECTIVE: Determine normal reference range of Tc-99m pertechne-tate thyroid uptake for thyroid scintigraphy in Saudi Arabia. DESIGN: Retrospective, cross-sectional. SETTING: Nuclear medicine service at tertiary care center in Riyadh. PATIENTS AND METHODS: We used data from biochemically euthyroid patients who underwent a thyroid Tc-99m pertechnetate scan while having parathyroid scintigraphy for hyperparathyroidism between April 2009 to April 2019. Medical records and biochemical thyroid function tests were reviewed and Tc-99m pertechnetate thyroid uptake values were determined for each patient. MAIN OUTCOME MEASURES: Thyroid uptake of Tc-99m pertechne-tate in euthyroid patients. SAMPLE SIZE: 167 RESULTS: The mean and median uptake of Tc-99m pertechnetate in euthyroid patients were 0.86% and 1.0%, respectively, and the inter-quartile range was 0.0–1.0%. The normal reference range in the study population was 0.2-2%. Thyroid uptake inversely correlated with age in females (r=−0.37, P P =.001), and for all patients (r=?0.39, P CONCLUSION: The range for normal thyroid Tc-99m pertechnetate was lower than the standard 1-4% range. Moreover, uptake decreased with age. Further studies are needed to establish the normal age-adjusted uptake for the thyroid Tc-99m pertechnetate scan. LIMITATIONS: Single center and retrospective. CONFLICT OF INTEREST: None.
- Published
- 2021
35. 99m Tc-Pertechnetate in Diagnosis of Meckel Diverticulum in an Adult.
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Kulaybi SA, Asiri JA, Asiri ZM, Alamri MA, Hassine H, and Aamry AI
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- Child, Male, Humans, Adult, Gastrointestinal Hemorrhage etiology, Radionuclide Imaging, Sodium Pertechnetate Tc 99m, Meckel Diverticulum diagnostic imaging
- Abstract
One of the most common malformations of the gastrointestinal tract is Meckel diverticulum (MD). MD complications can range from minor to major, such as intestinal obstruction, intussusception, hemorrhage, ulceration, vesicodiverticular fistulae, and tumors. Bleeding from ectopic gastric mucosa is more common in children than in adults. In the current case, MD in a 25-y-old man was diagnosed by
99m Tc-pertechnetate scanning.99m Tc-pertechnetate scanning helps to diagnose MD noninvasively and has a potential role in the evaluation of MD even in adults., (© 2023 by the Society of Nuclear Medicine and Molecular Imaging.)- Published
- 2023
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36. Preoperative imaging for hyperparathyroidism often takes upper parathyroid adenomas for lower adenomas.
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Van den Bruel A, Bijnens J, Van Haecke H, Vander Poorten V, Dick C, Vauterin T, and De Geeter F
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- Humans, Positron Emission Tomography Computed Tomography, Retrospective Studies, Sodium Pertechnetate Tc 99m, Parathyroid Neoplasms complications, Parathyroid Neoplasms diagnostic imaging, Parathyroid Neoplasms surgery, Hyperparathyroidism diagnostic imaging, Hyperparathyroidism surgery, Adenoma diagnostic imaging, Adenoma surgery
- Abstract
We retrospectively evaluated how accurately preoperative imaging localizes parathyroid adenoma in superior versus inferior parathyroids. Over 6 years, 104 patients with primary hyperparathyroidism underwent parathyroid surgery in a single centre. Of these, 103 underwent ultrasound, 97 [
99m Tc]pertechnetate/MIBI SPECT/CT and 30 [18 F]fluorocholine (FCH) PET/CT. One patient with a unilateral double adenoma was excluded from the analysis. Surgical findings with histopathologic confirmation of adenoma were used as the standard. Ultrasound misjudged 5 of 48 detected lower adenomas as upper, but 14 of 29 upper adenomas as lower (error rate 10 vs 48%, p = 0.0002). The corresponding error rates for [99m Tc]pertechnetate/MIBI SPECT/CT were 3 versus 55% (p = 0.000014), and for [18 F]FCH PET/CT 17 versus 36% (p = 0.26). Our results suggest that about half of the superior parathyroid adenomas which are detected, are erroneously assigned to the inferior position by both ultrasound and SPECT/CT imaging whereas the opposite mistake is significantly less frequent with ultrasound and SPECT/CT., (© 2023. The Author(s).)- Published
- 2023
- Full Text
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37. 99m Tc-pertechnetate thyroid static scintigraphy unexpectedly revealed ectopic gastric mucosa of upper esophagus.
- Author
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Ren Y, Jiang G, Meng Y, Chen J, and Liu J
- Subjects
- Humans, Female, Adult, Technetium, Gastric Mucosa diagnostic imaging, Single Photon Emission Computed Tomography Computed Tomography, Esophagus diagnostic imaging, Radiopharmaceuticals, Thyroid Gland diagnostic imaging, Sodium Pertechnetate Tc 99m
- Abstract
Technetium-99m (
99m Tc)-pertechnetate can be taken up by both gastric mucosa and thyroid tissue. Ectopic gastric mucosa of upper esophagus found in thyroid scintigraphy is rare. We reported a 31-year-old woman who underwent99m Tc-pertechnetate thyroid static scintigraphy for abnormal ultrasound findings. A focal uptake lesion was found in her upper chest. Single photon emission computed tomography/computed tomography (SPECT/CT) imaging showed increased uptake in multiple sites of the upper esophagus without significant thickening. Eventually, gastroscopic findings revealed multiple ectopic gastric mucosa of upper esophagus.- Published
- 2023
- Full Text
- View/download PDF
38. Thyroid segmentation using perithyroidal halo layer on 99m Tc-pertechnetate thyroid SPECT/CT: An easy and reliable method for accurate quantification of thyroid activity.
- Author
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Seo Y, Lee WW, Kang G, Shong MH, Joung KH, Kim SM, and Jun S
- Subjects
- Male, Female, Humans, Adult, Middle Aged, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Reproducibility of Results, Tomography, Emission-Computed, Single-Photon methods, Technetium, Thyroid Gland diagnostic imaging, Sodium Pertechnetate Tc 99m
- Abstract
Objective: In previous fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (
18 F-FDG PET/CT) studies, tumor segmentation using peritumoral halo layer (PHL; SegPHL) was shown to be reliable and accurate segmentation method in various malignant tumors. We found that the halo layer also was observed on the99m Tc-pertechnetate (99m TcO4 ) thyroid single photon emission computed tomography (SPECT)/CT. In the present study, we attempted to apply thyroid segmentation using the perithyroidal halo layer (PTHL; SegPTHL) on99m TcO4 thyroid SPECT/CT and compared SegPTHL with CT-based thyroid segmentation (SegCT)., Subjects and Methods: A total of 33 patients (19 females, 14 males; mean age, 46.91±15.7 years old) were enrolled in this study. For SegCT, three-dimensional volume of interest (VOI) of the thyroid was generated via multiple 2-dimensional regions of interest (ROI) along the thyroid margin on transaxial CT images that were manually drawn slice by slice. The PTHL was easily identified by an abrupt increase in layer thickness with minimal or mild distortion of the main thyroid contour, and the thyroid margin for SegPTHL was determined at the innermost portion of PTHL. An automated VOI generation for SegPTHL was performed using the Q. Volumetrix software. The correlation and reliability tests were performed between the quantification parameters of SegPTHL and SegCT., Results: The PTHL threshold adjusted according to maximal SUV of thyroid were similar to the results of previous SegPHLstudies of18 F-FDG PET/CT. A good correlation was observed between the thyroid volumes of SegCT and SegPTHL (r=0.725; P<0.0001), although the thyroid volume of SegPTHL was slightly larger than that of SegCT (P=0.0017). The % thyroid uptake (TcTU), total lesion activity (TLA), and mean standardized uptake value (SUVmean) of SegPTHL correlated well with those of SegCT (r=0.9877, 0.9883, 0.9875, respectively; P<0.0001). No significant error was observed between the parameters (i.e., TcTU, TLA, and SUVmean) of SegPTHL and SegCT., Conclusion: Thyroid segmentation PTHL may be a useful method for reliable quantification of thyroid uptake, because the SPECT/CT parameters of SegPTHL were strongly correlated with those of SegCT, as well as the process of SegPTHL is easier and faster than that of SegCT.- Published
- 2023
- Full Text
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39. Immobilizing Pertechnetate in Ettringite via Sulfate Substitution
- Author
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Daniel J. Bailey, Sebastian T. Mergelsberg, Tamas Varga, Antonia S. Yorkshire, Claire L. Corkhill, R. Matthew Asmussen, Jarrod V. Crum, Sarah A. Saslow, Sebastien N. Kerisit, Michelle M. V. Snyder, and Nancy M. Avalos
- Subjects
Minerals ,Ettringite ,Pertechnetate ,Sulfates ,Substitution (logic) ,Radioactive waste ,General Chemistry ,010501 environmental sciences ,01 natural sciences ,chemistry.chemical_compound ,chemistry ,Radioactive Waste ,Environmental Chemistry ,Sulfate ,Sodium Pertechnetate Tc 99m ,0105 earth and related environmental sciences ,Nuclear chemistry - Abstract
Technetium-99 immobilization in low-temperature nuclear waste forms often relies on additives that reduce environmentally mobile pertechnetate (TcO4-) to insoluble Tc(IV) species. However, this is ...
- Published
- 2020
40. Redox-Based Electrochemical Affinity Sensor for Detection of Aqueous Pertechnetate Anion
- Author
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Sayandev Chatterjee, Gabriel B. Hall, Nabajit Lahiri, Libor Kovarik, Eric D. Walter, Meghan S. Fujimoto, and Yingge Du
- Subjects
In situ ,Pertechnetate ,Affinity sensor ,Inorganic chemistry ,Bioengineering ,02 engineering and technology ,Electrochemistry ,01 natural sciences ,Redox ,Ion ,chemistry.chemical_compound ,Benzene Derivatives ,Sulfhydryl Compounds ,Isostructural ,Electrodes ,Groundwater ,Instrumentation ,Sodium Pertechnetate Tc 99m ,Fluid Flow and Transfer Processes ,Aqueous solution ,Chemistry ,Photoelectron Spectroscopy ,Process Chemistry and Technology ,010401 analytical chemistry ,Electrochemical Techniques ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Gold ,0210 nano-technology ,Oxidation-Reduction ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Rapid, selective, and in situ detection of pertechnetate (TcO4–) in multicomponent matrices consisting of interfering anions such as the ubiquitous NO3– and Cl– or the isostructural CrO42– is chall...
- Published
- 2020
41. Retrospective real-life study on preoperative imaging for minimally invasive parathyroidectomy in primary hyperparathyroidism
- Author
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Jacqueline Bijnens, Annick Van den Bruel, Vincent Vander Poorten, Ingeborg Goethals, Steven Van Schandevyl, Catherine Dick, and Frank De Geeter
- Subjects
Parathyroidectomy ,Technetium Tc 99m Sestamibi ,Tomography, Emission-Computed, Single-Photon ,Adenoma ,Multidisciplinary ,Hyperparathyroidism, Primary ,Parathyroid Glands ,Parathyroid Neoplasms ,Positron Emission Tomography Computed Tomography ,Medicine and Health Sciences ,Humans ,Radiopharmaceuticals ,Retrospective Studies ,Sodium Pertechnetate Tc 99m - Abstract
The objective of this study was to retrospectively evaluate preoperative imaging modalities for localization of parathyroid adenomas with a view to enable minimally invasive parathyroidectomy and in particular, to consider the contribution of 18F-fluorocholine-PET/CT. 104 patients with primary hyperparathyroidism, who underwent parathyroid surgery in a single centre during a 6-year period were included. Of these, 103 underwent ultrasound, 97 99mTc-Pertechnetate/SestaMIBI-SPECT, 20 MRI and 30 18F-fluorocholine-PET/CT. Based on surgical findings, sensitivities and specificities for correct lateralisation in orthotopic locations were: for ultrasound 0.75 (0.65–0.83) and 0.89 (0.81–0.94), for 99mTc-MIBI-SPECT 0.57 (0.46–0.67) and 0.97 (0.91–0.99), for MRI 0.60 (0.36–0.81) and 0.83 (0.59–0.96) and for 18F-fluorocholine-PET/CT 0.90 (0.73–0.98) and 0.90 (0.73–0.98). Correctly lateralized adenomas were significantly larger than those not found with ultrasound (p = 0.03) and SPECT (p = 0.002). Pre-operative PTH-levels were higher in single adenomas detected by scintigraphy than in those not (p = 0.02). 64 patients could be treated with a minimally invasive procedure. Cure after parathyroidectomy was obtained in 94% of patients. 18F-Fluorocholine-PET/CT could be shown to be a highly accurate modality to localize parathyroid adenomas preoperatively, obviating the need for total exploration in the majority of patients in whom ultrasound and scintigraphic results are discordant or both negative.
- Published
- 2022
42. Correlation of subtraction parathyroid scintigraphy with weight, pathohistologic finding and oxyphil cell content of parathyroid glands in parathyroid hyperplasia
- Author
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Dugonjić Sanja, Cerović Snežana, Janković Zoran, and Ajdinović Boris
- Subjects
radionuclide imaging ,sodium pertechnetate tc 99m ,parathyroid diseases ,parathyroid glands ,diagnosis ,sensitivity and specificity ,Medicine (General) ,R5-920 - Abstract
Background/Aim. Parathyroid hyperplasia (PHP) is defined as an absolute increase in the mass of parenchymal cells of the parathyroid gland. PHP is classified as primary, secondary and tertiary. The enlargement of parathyroid glands (PG) is usually asymmetric, resulting in a “dominant“ gland. In order to confirm the diagnosis, at least two glands should be examined histologically. Subtotal parathyroidectomy, i.e. removal of the three PG and leaving a small remnant of the forth, is the treatment of choice. High percent of PHP recurrence imposes the need for preoperative high sensitivity localizing procedures. Parathyroid scintigraphy localizes about 60% of hyperplastic glands. The aim of this study was to correlate findings of subtraction parathyroid scintigraphy (SPS) with weight, pathohistologic finding and oxyphil cell (OC) content of PG in patients with primary, secondary and tertiary parathyroid hyperplasia. Methods. Twenty-seven patients with primary/secondary PHP underwent SPS before surgery. Scintigraphic results were graded from 1-5, in relation to the degree of uptake. SPS graded 3, 4 and 5 were considered positive. The number and weight of operated PG were evaluated macroscopically. Pathohistologic and cellular types were defined on standard stained hematoxylin-eosin slides. OC content was defined as a percent of OC and graded from 1 to 3: grade 1 < 10%, grade 2 ≥ 10% and grade 3 ≥ 20% of OC. Results. SPS localized dominant gland in all patients with sensitivity 100%, and 51 from 73 hyperplastic PG, with sensitivity per gland of 70%. PG weighed 0.1 g to 6.7 g (median 1 g). A significant positive correlation (p < 0.0001) was found between the SPS results and PG weight. A significant positive correlation was found between PG weight and OC content (p = 0.0002). An insignificant correlation was found between SPS and OC content. Thirty-eight PG had < 10% of OC, 32 PG had < 10% and 3 PG had ≥ 20% of OC. Four patients had diffuse PHP and 23 patients nodular PHP. There was no statistically significant difference in SPS results compared to hyperplasia type, and between OC content and hyperplasia type. A significant positive correlation (p = 0.05) was found between PG weight and hyperplasia type. Conclusion. A high positive correlation was found between SPS results and PG weight, PG weight and OC content and PG weight and hyperplasia type. Between SPS results and OC content, and between SPS results and hyperplasia type, an insignificant correlation was found. Our results showed that SPS is a reliable and very sensitive diagnostic tool in detecting abnormal PG in parathyroid hyperplasia, reaching 100% sensitivity in detecting a “dominant gland” and sensitivity per localized gland of 70%. Causes that affect increased uptake of liposolubile Tc99m radiopharmaceuticals (RF) in the hyperfunctional PG tissue and conditions which prevent RF admission into the PG cells still remain to be accurately and precisely determined.
- Published
- 2012
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43. Precise measurement of intradermal fluid delivery using a low activity technetium-99m pertechnetate tracer
- Author
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Sahan A. Ranamukhaarachchi, Mehrsa Raeiszadeh, Boris Stoeber, Urs O. Häfeli, and Tullio V F Esposito
- Subjects
Injections, Intradermal ,Pertechnetate ,Swine ,medicine.medical_treatment ,030231 tropical medicine ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Delivery Systems ,0302 clinical medicine ,In vivo ,TRACER ,medicine ,Volume of fluid method ,Animals ,030212 general & internal medicine ,Saline ,Skin ,Sodium Pertechnetate Tc 99m ,Technetium 99m pertechnetate ,Vaccines ,General Veterinary ,General Immunology and Microbiology ,Public Health, Environmental and Occupational Health ,Low activity ,Rats ,Infectious Diseases ,chemistry ,Needles ,Molecular Medicine ,Female ,Radiopharmaceuticals ,Ex vivo ,Biomedical engineering - Abstract
A method was developed and validated to determine the intradermal (ID) fluid delivery potential of several ID devices, including hollow microneedles. The novel method used water soluble technetium-99 m pertechnetate (99mTcO4−) diluted in normal saline to measure the volume of fluid delivered to and remaining in the skin. The fluid that back-flowed to the skin surface and the fluid left on the device surface were also quantified, thus capturing all fluid volumes deposited during intradermal injections. The technique described in this manuscript was used to assess the injection performance of conventional hypodermic needles and hollow microneedles ex vivo using porcine skin and in vivo with a rat model. Since only a small fraction, 1.1%, of the water-soluble tracer remained bound to the skin when applied topically, the technique can be used to differentiate between injected fluid and backflow. Counting of gamma radiation from 99mTcO4− provided sub-nanoliter resolution for volume measurements, making the proposed method powerful, sensitive, and suitable for the assessments of ID injection devices, particularly for vaccine delivery.
- Published
- 2019
44. The clinical utility of SPECT/CT hybrid imaging on bleeding Meckel's diverticulum in adults
- Author
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Maria, Stathaki, Fotios, Psarakis, Eleni, Moustou, Nikolaos, Kapsoritakis, Elisavet, Anagnostopoulou, Olga, Bourogianni, Angeliki, Tsaroucha, Emmanouela, Papadaki, Maria, Tzardi, and Sophia, Koukouraki
- Subjects
Adult ,Meckel Diverticulum ,Tomography, Emission-Computed, Single-Photon ,Single Photon Emission Computed Tomography Computed Tomography ,Humans ,Radiopharmaceuticals ,Gastrointestinal Hemorrhage ,Sodium Pertechnetate Tc 99m - Abstract
Technetium-99m pertechnetate planar scintigraphy is the procedure of choice to localize ectopic gastric mucosa. However, single photon emission computed tomography/computed tomography (SPECT/CT) provides precise landmarks and scintigraphic findings. We report a case of an adult patient with Meckel's diverticulum involving an atypical location, within the pelvic region, next to the right margin of the urinary bladder. Imaging characteristics supported the diagnosis of either Meckel's or bladder diverticulum. Single photon emission computed tomography /CT was the key method to obtain definite diagnosis, since the low-dose CT revealed the presence of air within the lesion of radiotracer uptake. This finding was suggestive of an outpouching of the bowel wall.
- Published
- 2021
45. A preliminary biodistribution study of [
- Author
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Jaewoong, Jang, Yoshitaka, Kumakura, Katsuyoshi, Tatenuma, Atsuko Nakanishi, Ozeki, Youichiro, Wada, Nobuyoshi, Akimitsu, Akira, Tsuguchi, Hidetoshi, Kikunaga, Shogo, Higaki, and Mitsuru, Uesaka
- Subjects
Mice ,Mice, Inbred ICR ,Charcoal ,Sodium ,Animals ,Electrons ,Female ,Tissue Distribution ,Particle Accelerators ,Sodium Pertechnetate Tc 99m - Abstract
Production ofThe two types of [The clinical applicability of linac-AC-derived [
- Published
- 2021
46. Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats Biodistribuição de tecnécio-99m pertecnetato após desvio gástrico em Y de Roux (técnica de Capella) em ratos
- Author
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Amália Cínthia Meneses do Rêgo, Irami Araújo-Filho, Ítalo Medeiros Azevedo, Daniel Tôrres Jácome, Rachel de Alcântara Oliveira Ramalho, and Aldo Cunha Medeiros
- Subjects
Disponibilidade Biológica ,Cirurgia Bariátrica ,Pertecnetato Tc 99m de Sódio ,Compostos Radiofarmacêuticos ,Ratos ,Biological Availability ,Bariatric Surgery ,Sodium Pertechnetate Tc 99m ,Radiopharmaceuticals ,Rats ,Surgery ,RD1-811 - Abstract
PURPOSE: The biodistribution of sodium pertechnetate, the most used radiopharmaceutical in nuclear medicine, has not been studied in details after bariatric surgery. The objective was to investigate the effect of Roux-en-Y gastric bypass (RYGB) on biodistribution of sodium pertechnetate (Na99mTc-) in organs and tissues of rats. METHODS: Twelve rats were randomly divided into two groups of 6 animals each. The RYGB group rats were submitted to the Roux-en-Y gastric bypass and the control group rats were not operated. After 15 days, all rats were injected with 0.1mL of Na99mTc- via orbital plexus with average radioactivity of 0.66 MBq. After 30 minutes, liver, stomach, thyroid, heart, lung, kidney and femur samples were harvested, weighed and percentage of radioactivity per gram (%ATI/g) of each organ was determined by gama counter Wizard Perkin-Elmer. We applied the Student t test for statistical analysis, considering pOBJETIVO: Avaliar o efeito da cirurgia de desvio gástrico em Y de Roux (BGYR) na biodistribuição do pertecnetato de sódio (Na99mTc) em órgãos e tecidos de ratos. MÉTODOS: Doze ratos Wistar foram aleatoriamente distribuidos em dois grupos de seis animais cada. O grupo BGYR foi submetido a técnica cirúrgica do desvio gástrico em Y de Roux e o grupo controle não foi operado. No 15º dia de pós-operatório foi administrado 0,1 ml IV de Na99mTc aos animais dos dois grupos, com atividade radioativa média de 0,66MBq. Após 30 minutos os ratos foram mortos e retirados fragmentos de fígado, estômago, tireóide, coração, pulmão, rim e fêmur. As amostras foram lavadas com solução salina 0,9% pesadas e submetidas ao Contador Gama 1470, WizardTM Perkin-Elmer para se determinar o percentual de atividade radiotiva por grama (%ATI/g) de cada órgão. Empregou-se o teste t de Student para análise estatística, considerando p
- Published
- 2010
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- View/download PDF
47. Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats Efeito de um extrato de Aloe vera na biodistribuição do pertecnetato de sódio (Na99mTcO4) em ratos
- Author
-
Cecília Maria de Carvalho Xavier Holanda, Monique Batista da Costa, Natália Chilinque Zambão da Silva, Maurício Ferreira da Silva Júnior, Vanessa Santos de Arruda Barbosa, Roseane Pereira da Silva, and Aldo da Cunha Medeiros
- Subjects
Aloe ,Plantas Medicinais ,Radioisótopos ,Pertecnetato Tc 99m de Sódio ,Tecnécio ,Ratos ,Plants, Medicinal ,Radioisotopes ,Sodium Pertechnetate Tc 99m ,Technetium ,Rats ,Surgery ,RD1-811 - Abstract
PURPOSE: Aloe vera is a tropical plant popularly known in Brazil as babosa. We have investigated the effect of aqueous extract of Aloe vera on the biodistribution of Na99mTcO4 and laboratorial parameters in Wistar rats. METHODS: Twelve animals were divided into treated and control groups. In the treated group, Aloe vera was given by gavage (5mg/mL/day) during 10 days. The control group received sorbitol by the same way and period. One hour after the last dose, we injected 0.1mL of Na99mTcO4 by orbital plexus. After 60 min, all the animals were killed. Samples were harvested from the brain, liver, heart, muscle, pancreas, stomach, femur, kidneys, blood, testis and thyroid and the percentage of radioactivity (%ATI/g) was determined. Biochemical dosages were performed. RESULTS: There was a significant increase of %ATI/g in blood, femur, kidneys, liver, stomach, testis and thyroid and also in blood levels of AST and ALT. A significant decrease in levels of glucose, cholesterol, triglycerides, creatinine and urea occurred. The statistical analyses were performed by Mann-Whitney test and T-Student test (pOBJETIVO: Aloe vera é uma planta tropical popularmente conhecida no Brasil por "babosa". Investigou-se o efeito de extrato aquoso do A. vera na biodistribuição do pertecnetato de sódio (Na99mTcO4) e em parâmetros laboratoriais de ratos Wistar. MÉTODOS: Doze animais foram divididos em 2 grupos: tratado e controle. No grupo tratado, o extrato de A. vera foi administrado via oral (5mg/mL/dia) por 10 dias. O grupo controle recebeu sorbitol do mesmo modo. Uma hora após a última dose, ambos receberam 0,1mL de Na99mTcO4 via plexo orbital. Após 60 minutos, os animais foram sacrificados. Foram retiradas amostras do cérebro, fígado, coração, músculo, pâncreas, estômago, fêmur, rins, sangue, testículos e tiróide e determinou-se o percentual de radioatividade por grama (%ATI/g) de cada uma. Dosagens bioquímicas foram realizadas. RESULTADOS: Houve um aumento significativo do %ATI/g no sangue, fêmur, rins, fígado, estômago, testículos e tiróide e nos níveis sanguíneos das enzimas AST e ALT. Ocorreu uma diminuição significativa dos níveis de glicose, colesterol, triglicérides, creatinina e uréia. Análises estatísticas foram feitas pelos testes de Mann-Whitney e T-student (p
- Published
- 2009
- Full Text
- View/download PDF
48. Dissemination of bacteria labeled with technetium-99m after laparotomy and abdominal insufflation with different CO2 pressures on rats Disseminação de bactérias marcadas com tecnécio-99m após laparotomia e insuflação com diferentes pressões de CO2 em ratos
- Author
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Marcos Bettini Pitombo, Clarice Abreu dos Santos Albuquerque de Faria, Luciana Camargo Bernardo, Klaus Steinbruck, and Mario Bernardo Filho
- Subjects
Peritonite ,Pneumoperitônio ,Escherichia coli ,Pertecnetato Tc 99m de Sódio ,Ratos, Wistar ,Peritonitis ,Pneumoperitoneum ,Sodium Pertechnetate Tc 99m ,Rats, Wistar ,Surgery ,RD1-811 - Abstract
PURPOSE: To asses the dissemination of bacteria labeled with technetium-99m (99mTc) from peritoneal cavity after different surgical procedures. METHODS: Bacteria of the Escherichia coli species labeled with 99mTc were used in a concentration of 10(8) units of colony-makers for ml (UFC/ml) and 1ml was inoculated through intra-peritoneal via. Forty-eight rats were divided into four groups: control, laparotomy, pneumoperitoneum with 10mmHg and pneumoperitoneum with 20mmHg of CO2. Procedures were performed 20 min after injection of the inoculum and lasted 30 min. Animals were sacrificed after six hours (Group 1) and 24 hours (Group 2). Samples of blood, liver and spleen were collected for radioactivity counting. RESULTS: After six hours, indirect detection of the bacteria in different organs was uniform in all groups. After 24 hours, a larger detection of technetium was observed in the livers of animals of the group insufflated with 20mmHg of CO2, when compared with those of control group (pOBJETIVO: Avaliar a disseminação de bactérias marcadas com tecnécio-99m (99mTc) a partir da cavidade peritoneal após diferentes procedimentos cirúrgicos. MÉTODOS: Foram utilizadas bactérias da espécie Escherichia coli marcadas com 99mTc em uma concentração de10(8) unidades formadoras de colônia por ml (UFC/ml) sendo inoculado 1ml por via intra-peritoneal. Quarenta e oito ratos foram divididos em quatro grupos: controle, laparotomia, pneumoperitôneo com 10 mmHg e pneumoperitôneo com 20 mmHg de CO2. Os procedimentos foram realizados 20 minutos após a injeção do inóculo e duraram 30 minutos. Os animais foram sacrificados após seis horas (grupo 1) e 24 horas (grupo 2). Foram coletadas amostras de sangue, fígado e baço para contagem radioativa. RESULTADOS: Após seis horas, a detecção indireta das bactérias nos diferentes órgãos foi uniforme em todos os grupos. Após 24 horas, observou-se uma maior detecção de tecnécio nos fígados dos animais do grupo insuflado com 20 mmHg de CO2, quando comparados aos do grupo controle (p
- Published
- 2008
- Full Text
- View/download PDF
49. Apical Sealing Ability of Two Calcium Silicate-Based Sealers Using a Radioactive Isotope Method: An In Vitro Apexification Model
- Author
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Eunice Carrilho, Siri Paulo, José Pedro Martinho, Catarina Carvalho, Maria Filomena Botelho, Carlos Miguel Marto, Manuel Marques Ferreira, Inês Raquel Pereira, Anabela Paula, Ana Coelho, and Ana M. Abrantes
- Subjects
Mineral trioxide aggregate ,Technology ,Dentistry ,Article ,Sodium pertechnetate ,chemistry.chemical_compound ,Putty ,calcium silicate ,Statistical significance ,General Materials Science ,Radionuclide ,mineral trioxide aggregate ,Microscopy ,QC120-168.85 ,business.industry ,QH201-278.5 ,apexification ,Engineering (General). Civil engineering (General) ,In vitro ,dental leakage ,TK1-9971 ,chemistry ,Descriptive and experimental mechanics ,Calcium silicate ,Apexification ,Electrical engineering. Electronics. Nuclear engineering ,sodium pertechnetate Tc 99m ,TA1-2040 ,business - Abstract
The aim of this study was to evaluate and compare the sealing ability of two calcium silicate-based sealers (TotalFill BC RRM Fast Set Putty and White ProRoot MTA) when used as apical plugs in immature teeth through nuclear medicine. Single-rooted extracted teeth (n = 34) had their crowns and root tip sectioned to obtain 14 mm long root segments to simulate an in vitro apexification model. Were created two experimental groups, namely MTA (n = 12) and BC (n = 12), and two control groups, PG (positive group, n = 5) and NG (negative group, n = 5). On the 4th day after placing the respective apical plug, the apical portions of the teeth were submerged in a solution of sodium pertechnetate (99mTcNaO4) for 3 h. Statistical analysis showed a significant difference between the MTA group and the controls (p <, 0.05). The BC group had a significant difference regarding the negative control (p <, 0.001) but showed no statistical significance regarding the positive control (p = 0.168). There was a statistically significant difference (p = 0.009) between the BC group (7335.8 ± 2755.5) and the MTA group (4059.1 ± 1231.1), where the last showed less infiltration. Within the limitations of this study, White ProRoot MTA had a significantly better sealing ability than TotalFill BC RRM Fast Set Putty.
- Published
- 2021
50. Meckel diverticulum scintigraphy: technique, findings and diagnostic pitfalls.
- Author
-
Aboughalia HA, Cheeney SHE, Elojeimy S, Blacklock LC, and Parisi MT
- Subjects
- Child, Humans, Tissue Distribution, Radiopharmaceuticals, Radionuclide Imaging, Gastrointestinal Hemorrhage diagnostic imaging, Sodium Pertechnetate Tc 99m, Meckel Diverticulum diagnostic imaging, Musculoskeletal Diseases
- Abstract
Meckel diverticulum, the most common congenital anomaly of the gastrointestinal tract, results from the aberrant involution of the omphalomesenteric duct and accounts for more than 50% of unexplained lower gastrointestinal bleeding in the pediatric population. The most accurate imaging tool to identify a Meckel diverticulum containing ectopic gastric mucosa is the Technetium-99m pertechnetate Meckel scan, a scintigraphic study with a reported accuracy of 90% in the pediatric population. In addition to depicting a Meckel diverticulum with ectopic gastric mucosa, careful attention to the normal biodistribution of the radiotracer can lead to the identification of unexpected pathology with implications for patient management. This article serves to review the embryological origin and anatomical features of Meckel diverticulum, highlight the role of scintigraphy in evaluating Meckel diverticulum, and discuss the proper imaging technique when performing this test. We will focus on pitfalls that can lead to an erroneous diagnosis as well as incidental findings that can affect patient management., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
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