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A series of sterically varied silver‐based N‐heterocyclic carbene (NHC) complexes (14–17) were synthesized by embroidering biomedically active coumarin and 1,2,4‐triazole core as NHC precursors (10–13). The structure of all the synthesized salts (10–13) and complexes (14–17) were elucidated by FT‐IR and NMR (proton and carbon) spectroscopic techniques. Complex 15 was characterized by single‐crystal x‐ray diffraction. The data obtained from this characterization of the small molecule 15 confirmed the three‐dimensional arrangement of the complex. This also indicated agostic‐type interactions between the Ag atom and the CH modules of one of the NHC ligands. Further, the synthesized complexes (14–17) were studied for the antihaemolytic, anticoagulant and anticancer activities. The complexes 15 and 17 exhibited anticoagulant properties comparable to that of the standard anticoagulant EDTA. Notably, all the complexes evidenced anticancer activity on leukaemic cell lines (K562) with the IC50 values below 100 μM, the concentration at which antihaemolytic property was evidenced. Complex 15 exhibited the lowest IC50 value of 18.44 ± 0.76 μM, which could be attributed by the appropriate steric bulk around the metal atom. The cumulative data of the three analyses validate potential of the complexes 15 and 17 to exhibit antihaemolytic, anticancer and anticoagulant properties. [ABSTRACT FROM AUTHOR]

Cancer is a leading cause of death, so continuous efforts into cancer therapy are imperative. In tumor cells, telomerase and oncogene activity are key points for uncontrolled cell growth. Targeting these processes with ligands that inhibit telomerase and/or reduce oncogene expression has been identified as a promising cancer therapy. This study evaluated the selectivity and affinity of the silverII complex of 5,10,15,20-tetrakis(N-methyl-4-pyridinium)porphyrin (AgTMPyP) to stabilize DNA sequences capable of forming G4 structures mimicking the telomeric and oncogene regions, using spectroscopic, biochemical methods and in vitro assays. The tetracationic silver complex was compared with the free base, H2TMPyP, and the zincII complex, ZnTMPyP. The results obtained from UV-Vis and fluorescence methods pointed to a great affinity and good selectivity of AgTMPyP to G4 structures, especially for the oncogene MYC. In general, an increase in the ability of the studied ligands for 1O2 generation when interacting with oncogenic and telomeric G4 sequences was found. The results of the PCR stop assays proved that AgTMPyP has the ability to inhibit Taq polymerase. Additionally, in vitro assays demonstrated that the silverII complex exhibits low cytotoxicity against HaCaT— an immortalized, non-tumorigenic, skin keratinocytes cell line—and, although nonexclusive, AgTMPyP shows nuclear co-localization. [ABSTRACT FROM AUTHOR]

Three silver N‐heterocyclic carbene (NHC) complexes (Ag1–Ag3) were designed and synthesized using quinoline‐functionalized benzoimidazole salts (L1–L3). Both NHC precursors and resultant silver‐NHC complexes were characterized by NMR, FT‐IR spectroscopy, and elemental analysis. X‐ray diffraction analysis was additionally performed to investigate the crystal structures of these silver‐NHC complexes. The results showed that Ag1 is a dinuclear silver complex with a deviated linear geometry. Ag2 has a disilver core in which two silver atoms are coordinated by two quinoline‐functionalized carbene ligands and one acetonitrile molecule. The silver‐NHC complex Ag3 is composed of a silver‐triangle formed by three silver atoms and three carbene ligands. The in vitro cytotoxic studies revealed that silver‐NHC complexes had stronger antitumor activity than their corresponding NHC precursors. Notably, after a 24‐h exposure to cancer cells, Ag2 presented the highest cytotoxicity with a half maximal inhibitory concentration (IC50) at 1.74 ± 0.08 μM in A2780 cells, which was approximately 14‐fold lower than that of the clinically approved metallodrug cisplatin (IC50 = 24.74 ± 1.35 μM). Detailed mechanistic studies suggested that the complex Ag2 provoked intracellular reactive oxygen species (ROS) overproduction and mitochondrial membrane depolarization, which eventually resulted in mitochondrial dysfunction and cell potent necrosis. Overall, our studies show that NHC‐coordinated silver complexes can be readily constructed and used as an attractive class of anticancer agents, which is conductive for further investigation of their therapeutic potential for treating cisplatin‐resistant cancers. [ABSTRACT FROM AUTHOR]

Hexakis(4‐trimethylsilylpyrazol‐1‐yl)ethane was synthesized by the oxidative dimerization of tris(4‐trimethylsilylpyrazol‐1‐yl)methane. Single‐crystal X‐ray structural analysis of hexakis(4‐trimethylsilylpyrazol‐1‐yl)ethane showed that the ethane C−C bond (1.623(4) Å) is shorter than that in hexaphenylethane (1.67(3) Å). In solution, hexakis(4‐trimethylsilylpyrazol‐1‐yl)ethane existed as a single species, contrastive that conventional hexaphenylethanes can keep the central C−C bond only by the aid of additional bridges between the two triarylmethyl units. Theoretical calculations indicated that the tris(pyrazol‐1‐yl)methyl radical, which is anticipated to be under equilibrium with hexakis(pyrazol‐1‐yl)ethane, is less stable than trityl radicals due to lack of delocalization of the radicals. Furthermore, introduction of pyrazole groups allowed additional bridging between the two triarylmethyl moieties through metal coordination to the adjacent N atoms: hexakis(4‐trimethylsilylpyrazol‐1‐yl)ethane exhibited unique coordination to three Ag atoms affording a hexaarylethane analog bearing three N−Ag−N bridges. [ABSTRACT FROM AUTHOR]

Silver nitrate reacts with 6‐methylmercaptopurine riboside (6‐MMPR) in aqueous solution containing methanol and dimethyl sulfoxide at room temperature to give a colourless crystalline complex, namely, bis(6‐methylmercaptopurine riboside‐κN7)(nitrato‐κ2O,O′)silver(I) 2.32‐hydrate, [Ag(NO3)(C11H14N4O4S)2]·2.32H2O. The crystal structure, determined from synchrotron diffraction data, shows a central AgI ion on a crystallographic twofold rotation axis, coordinated in an almost linear fashion by two 6‐MMPR ligands via atom N7 (purine numbering), with the nitrate counter‐ion loosely coordinated as a bidentate ligand, forming a discrete molecular complex as an approximate dihydrate. The complex and water molecules are connected in a three‐dimensional network by hydrogen bonding. [ABSTRACT FROM AUTHOR]

The use of AgNO3-polyvinyl alcohol (PVA) ink and oxygen plasma to form conductive coatings on plastic substrates was studied. It was found that oxygen plasma can decompose silver complexes to form metallic silver without high-temperature heating. The AgNO3-PVA ratio and plasma parameters (time, power) were optimized to obtain uniform conductive coatings. The morphology and electrical characteristics of the coatings were evaluated. Composite coatings with high reflectivity and good adhesion were prepared with a resistivity of 1.66 × 10−6 Ω·m using MOD inks with a silver ion mass fraction of 5%, after 300 W plasma treatment of the PET substrate for 2 min (the chamber temperature was 37.3 °C). These results demonstrate the potential feasibility of silver MOD inks and oxygen plasma treatment for the production of silver connectors, electromagnetic shielding films, and antimicrobial coatings on low-cost plastic substrates. [ABSTRACT FROM AUTHOR]

Entangled (M3L2)n polyhedral complexes represent a unique class of supramolecular architectures that are stabilized by relatively weak metal–acetylene interactions in cooperation with conventional metal–pyridyl coordination. Counter‐anion exchange of these complexes with a nitrate (NO3−) ion triggered formal metal insertion between the metal centers, and a heteroleptic ternary coordination mode with acetylenic, pyridyl, and nitrate donors was generated on the metal centers. As a result, the main frameworks of the polyhedral complexes M18L12 and M12L8 were formally extended into a new series of concave polyhedra having the compositions M21L12 and M13L8, respectively. This transformation also resulted in the local disconnection of the highly entangled trifurcate topology of the framework, providing clues toward the skeletal editing of extended and complex three‐dimensional (3D) architectures. [ABSTRACT FROM AUTHOR]

A new benzimidazolium salt containing a 2,5-dimethylbenzyl substituent and six N-heterocyclic carbene (NHC) silver complexes were prepared. The complexes were characterized by NMR, FTIR, and LC-MS spectroscopic methods and elemental analyses. They are stable in solution for a week. The antibacterial properties of the Ag(I) complexes against two Gram-positive and two Gram-negative bacteria were investigated. Inhibition zone and minimum inhibitory concentration (MIC) data establish that these NHC-Ag(I) complexes possess antibacterial activities; 2b showed the highest antibacterial activity overall against Gram-positive and Gram-negative bacteria. [ABSTRACT FROM AUTHOR]

• Synthesis of bis(N-alkylbenzimidazole)silver(I) nitrate. • Antimicrobial activities. • Antibiofilm activities. • Molecular docking study to understand the mechanisms of action. This study investigates the antimicrobial and antibiofilm potential of three silver(I) complexes derived from N -alkylbenzimidazole derivatives: bis[(Z)-1-styryl-benzimidazole]silver(I) nitrate (4), bis[(E)-1-styryl-benzimidazole]silver(I) nitrate (5), and bis(1-cinnamyl-benzimidazole)silver(I) nitrate (6). Detailed synthesis and characterization of these complexes are followed by assessments of their efficacy against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli , and Candida albicans. Among the tested compounds, complex 6 exhibited the highest antimicrobial activity, with a minimal inhibitory concentration of 6 µmol/L against P. aeruginosa , and significant antibiofilm activity, achieving 67.72 % inhibition at a concentration of 3 µmol/L. These interesting findings led us to conduct a molecular docking study to understand the mechanisms of action by investigating the interactions between the silver(I) complexes and some key protein targets involved in bacterial and fungal biofilm formation, including (p)ppGpp synthetase/hydrolases, FtsZ proteins, and pyruvate kinases. This comprehensive approach, combining experimental and computational analyses derived from N -alkylbenzimidazole derivatives, particularly complex 6 , which exhibits remarkable efficacy against various pathogens, reveals promising therapeutic applications of these silver(I) complexes and advances our understanding of their potential mode of action against biofilm-associated infections. [Display omitted] [ABSTRACT FROM AUTHOR]

Metal complexes gained more attention in the medical field, particularly cancer treatment, due to their enhanced potential and redox ability. These complexes exhibited more significant antiproliferation potential by triggering the generation of reactive oxygen species (ROS), altering cell membrane, changing cell redox potential and by DNA replication inhibition. Platinum-based metal complex Cisplatin was prepared. It was widely used in treating lung, breast, ovarian and testicular cancers; however, these complexes showed many adverse effects such as renal insufficiency and electrolyte abnormalities, neurotoxicity, ototoxicity, nausea, vomiting and drug resistance. To overcome these side effects and drug resistance mechanisms, silver metal is highly employed as a cytotoxic agent by DNA binding through the formation of disulphide bonds. Moreover, silver complexes exhibited more significant cytotoxicity with the lowest toxicity. This review highlighted silver complexes' anticancer and cytotoxic potential with various bioactive ligands.

In this study, four novels 2,5,6-trisubstituted imidazothiadiazole derivative ligands and their Ag(I) complexes were synthesized and characterized using various spectroscopic analysis techniques. First, imidazo[2,1-b][1,3,4]thiadiazole derivative (3) was obtained from the reaction of 5-amino-1,3,4-thiadiazole-2-thiol with benzyl bromide in the presence of KOH in an ethanolic medium. In the next step, the resultant compound reacted sequentially with four substituted phenacyl bromide derivatives (4a-4d) under refluxed ethanol for 24 h to obtain substituted 2-(benzylthio)-6-phenylimidazo[2,1-b][1,3,4]thiadiazole derivatives (5-8). Compounds (9-12) were obtained by attaching a carbonyl group to carbon number 5 of the imidazothiadiazole group in these compounds with the help of Vilsmeier-Haack reagent. The resultant compounds were reacted in an ethanolic medium to synthesize the novel (13-16) ligands by adding ethylenediamine in a 1:2 molar ratio. The Ag(I) complexes of the resultant ligands were synthesized by mixing silver acetate with the ligands in a dimethyl sulfoxide medium to obtain (17-20) complexes. All the synthesized compounds were analyzed using FTIR, 1 H NMR, 13 C NMR, mass spectroscopy, magnetic susceptibility, ICP-OES, and thermogravimetric analysis techniques. The study also investigates the in vitro cytotoxic effect of the ligands and complexes on A549 (nonsmall cell lung cancer) cells using the MTT assay and shows that the 13, 15, and 16 ligands, together with their complexes, exhibit potent cytotoxicity. In addition, in silico molecular docking simulations were conducted both to support the in vitro cytotoxicity experiments and to ascertain the active binding sites and interactions of the ligands and complexes on the EGFR receptor. The result indicates that ligands and complexes may serve as promising candidates for further investigation as anticancer agents., (© 2025 The Author(s). Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.)

In the title compound, [Ag(CF3SO3)(C10H6F2N2)2], the AgI centre adopts a highly distorted trigonal–planar coordination environment resulting from its coordination by one O atom of the trifluoromethanesulfonate anion and the pyridine N atoms of two crystallographically independent 2′,6′-difluoro-2,3′-bipyridine ligands, which display very similar conformations to one another. Pairwise Ag...O–SO2CF3− [Ag...O = 2.8314 (14) Å] interactions and intermolecular C—H...O interactions between inversion-related units lead to the formation of an eight-membered cyclic dimer in which the silver atoms are separated by 6.2152 (3) Å. In the crystal, the dimers are linked through C—H...O hydrogen bonds, halogen...π and weak π–π stacking interactions, resulting in the formation of a three-dimensional supramolecular network. The title compound exhibits a strong and broad emission band from 400 nm to 550 nm in solution and its photoluminescence quantum efficiency is estimated to be ca 0.2, indicating that the title compound could have applications as an emitting material in organic light-emitting diodes (OLEDs).

A new silver complex, namely [Ag(OBz)(PTA)2] (where OBz = benzoate and PTA = 1, 3, 5-triazaphospadamantane) has been synthesized and structurally characterized. The silver center resides in a triangular coordination environment, noticeably deviated from the plane defined by three ligands. [Ag(OBz)(PTA)2] has excellent aqueous solubility and also moderate solubility in organic media. Antibacterial studies indicated the effectiveness of this complex towards growth inhibition of three nosocomial pathogens, namely, B. cereus, S. aureus and P aeruginosa. The MIC and IC50 values clearly suggested that the complex induced more significant antibacterial activity against the Gram (+) strains compared to the Gram (−) variety.

In the title compound, [Ag(CF3SO3)(C10H6F2N2)2], the AgI centre adopts a highly distorted trigonal–planar coordination environment resulting from its coordination by one O atom of the tri­fluoro­methane­sulfonate anion and the pyridine N atoms of two crystallographically independent 2′,6′-di­fluoro-2,3′-bi­pyridine ligands, which display very similar conformations to one another. Pairwise Ag···O–SO2CF3− [Ag···O = 2.8314 (14) Å] inter­actions and inter-­molecular C—H···O inter­actions between inversion-related units lead to the formation of an eight-membered cyclic dimer in which the silver atoms are separated by 6.2152 (3) Å. In the crystal, the dimers are linked through C—H···O hydrogen bonds, halogen···π and weak π–π stacking inter­actions, resulting in the formation of a three-dimensional supra­molecular network. The title compound exhibits a strong and broad emission band from 400 nm to 550 nm in solution and its photoluminescence quantum efficiency is estimated to be ca 0.2, indicating that the title compound could have applications as an emitting material in organic light-emitting diodes (OLEDs). [ABSTRACT FROM AUTHOR]

Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceutical industry has to find new candidates and strategies to develop novel and efficient drugs. They increasingly use computational tools in R&D stages for screening extensive sets of drug candidates before starting pre‐clinical and clinical trials. N‐Heterocyclic carbenes (NHCs) can be evaluated as good drug candidates because they offer both anti‐cancer and anti‐inflammatory features with their general low‐toxicity profiles. To date, different kinds of NHCs (Cu, Co, Ni, Au, Ag, Ru, etc.) have been synthesized and their therapeutic uses has been shown. Here, we have reviewed the recent studies focused on Ag(I)‐NHC complexes and their anti‐cancer activities. Also, existing examples of the usage of density functional theory and structure–activity relationship have been evaluated. [ABSTRACT FROM AUTHOR]

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The bis-ortho-thioether 9,10-bis[(o-methylthio)phenyl]anthracene was synthesized as a syn-atropisomer, as revealed by X-ray diffraction. This alkylaryl thioether ligand (L) formed different macrocyclic complexes by coordination with silver(I) salts depending on the nature of the anion: M2L2 for AgOTf and AgOTFA, M6L4 for AgNO3. A discrete M2L complex was obtained in the presence of bulky PPh3AgOTf. These silver(I) complexes adopted similar structures in solution and in the solid state. As each sulfur atom in the ligand is prochiral, macrocycles L2M2 were obtained as mixtures of diastereoisomers, depending on the configurations of the sulfur atoms coordinated to silver cations. The X-ray structures of the two L2·(AgOTf)2 stereoisomers highlighted their different geometry. The catalytic activity of all silver(I) complexes was effective under homogeneous conditions in two tandem addition/cycloisomerization of alkynes using 0.5–1 mol % of catalytic loading.

Background/Aims: The ubiquitin proteasome system (UPS) is responsible for the degradation of most intracellular proteins, and proteasomal deubiquitinases (DUBs) have recently been highlighted as novel anticancer targets. It is well documented that copper complexes can inhibit UPS function through targeting both 20S proteasome and proteasomal DUBs. The antineoplastic activities of silver complexes have received much attention, but the exact mechanisms are not fully elucidated. In this study, we aim to investigate the effects of a novel silver complex [Ag(S2CN(C2H5)2)]6 (AgDT) on UPS function and its anticancer potential in non-small cell lung cancer (NSCLC). Methods: Cell viability assay (i.e., the MTS assay) and flow cytometry assay were used to analyze the cell viability and apoptosis. Proteasome inhibition was measured using 20S proteasome activity assay and 19S proteasomal DUBs activity assay. Western blot analysis and immunohistochemistry were performed to detect protein levels. The in vivo antitumor activity of AgDT was assessed with nude xenografts. Results: Silver ions, alone or in combination with disulfiram (DSF), induced UPS inhibition in NSCLC cells mainly through inhibition of proteasomal DUBs activities. Silver complex AgDT triggered intracellular accumulation of ubiquitinated proteins, and prevented the degradation of surrogate substrate GFPu. Mechanistically, AgDT potently inhibited the activities of proteasomal DUBs USP14 and UCHL5, without altering the 20S proteasome peptidases. Moreover, AgDT induced apoptosis in NSCLC cells and significantly inhibited tumor growth in xenografts. Conclusion: Our findings suggest that silver complex AgDT is a novel metal-based proteasomal DUBs inhibitor, and pharmacologic inhibition of USP14 and UCHL5 could prove to be an effective therapeutic strategy for NSCLC.

The formation of Ag(I)‐1,2,4,5‐tetrazines(ttz) based coordination polymers via the Ag−N coordination and anion−π interactions is described. Coordination‐driven self‐assembly is a key step to construct coordination polymers, and ttz, an electron‐deficient aromatic ring compound, forms interesting anion−π interactions. In this study, a series of silver salts, AgX [X = BF4, PF6 and CF3SO3 (OTf)], is introduced to determine the influence of shape and size of anions on the formation of coordination polymers, {[Ag(ttz)](BF4)}n (1), {[Ag2(ttz)3](PF6)2}n (2) and {[Ag2(ttz)3(OTf)](OTf)}n (3). It shows different types of channels in polymers and the coordination modes of ttz (μ, μ3, and μ4). The structure of coordination polymers and the influence of anion−π interactions are revealed by single crystal X‐ray diffraction. In particular, 3 shows not only the anion−π interaction but also the coordination between the anion and Ag(I) which contributes to the unique framework compared to 1 and 2. [ABSTRACT FROM AUTHOR]

A silver–cytokinin complex filler was synthesized by a mild thermal process; then, the complex was mixed with an aqueous emulsion paint as an antimicrobial filler. Coating films were prepared by a typical method using 0.254 mm applicator. The results of antibacterial activity measurements indicated that the films exhibited strong activities against Escherichia coli and Staphylococcus aureus. Values of the antibacterial activity (n = 3) were 5.7 and 4.9, respectively. As for the mixture of five kinds of fungi, after cultivation (n = 5), no colony growth on the film surface was observed by microscopy. From the appearance of the film surfaces, it was revealed that the silver–cytokinin complex filler for emulsion paints possessed better paintability and transparency compared to a commercialized paint filler. [ABSTRACT FROM AUTHOR]

The reaction of 2-bromoaniline with sodium nitrite affords a triazenido compound, 1,3-bis[(2-bromo)benzene]triazene (HL). Spectroscopic investigations show that HL bears a high selectivity for silver(I) ion in the presence of other metal ions. In the presence of Et3N, the reaction of HL and AgNO3 gives a binuclear triazenido-silver complex, [Ag2(L)2], which has been determined by X-ray diffraction analysis. Electrochemical studies show this silver complex can act as an electrocatalyst for hydrogen generation from neutral water with a turnover frequency (TOF) of 874.14 moles of hydrogen per mole of catalyst per hour (mol H2/mol catalyst/h) at an over potential (OP) of 837.6 mV. [ABSTRACT FROM AUTHOR]

Summary of main observation and conclusion: The coordination of silver cation to diphosphene Mes*P=PMes* (1, Mes* = tBu3C6H2) was investigated in detail. The reaction of 1 with Ag[Al(ORF)4] (ORF = OC(CF3)3) in the ratios of 2 : 1, 3 : 2 and 1 : 2 led to the formation of the first cationic silver linked diphosphene complexes 2—4. Complexes 2 and 3 contain two and three diphosphene molecules linked by the linear Ag(I) cation, respectively, and they feature unusual zig‐zag topologies. Complex 4 is a dinuclear silver complex, and each Ag(I) center features a tetrahedral geometry, coordinated by one phosphorus atom of diphosphene 1 and three chloro atoms of two CH2Cl2 molecules. [ABSTRACT FROM AUTHOR]

• A novel silver(I) complex was prepared through a facile green synthesis route. • The complex was used as a solid-state precursor to prepare nano-sized Ag and Ag 2 O. • The complex exhibited good antibacterial activities. • The complex showed anti-proliferative activity against MCF-7 cancer cells. • The proposed approach is facile, green, and user-friendly. A new silver complex, [Ag(2-pymc)(NO 3)] (Ag-1) [2-pymc = methyl-2-(pyridine-2yl-methylene) hydrazinecarboxylate], was prepared and subjected to elemental analysis including Fourier transform infrared (FT-IR) and ultraviolet–visible (UV–vis) spectroscopic methods. Single-crystal X-ray diffraction (SC-XRD) study demonstrated [Ag(2-pymc)(NO 3)] monomers in the crystal structure. The silver ion is triple coordinated by an N, N-chelating 2-pymc and one oxygen atom of a monodendate nitrate anion. Interestingly, Ag-1 acted as a single-source, solid-state molecular precursor (SSMP) for synthesizing both Ag and Ag 2 O nanoparticles (NPs) at different reaction conditions. The crystallinity and purity of the as-synthesized Ag and Ag 2 O NPs were investigated by powder XRD, whereas the size and surface morphology were determined by TEM analysis. The results showed that the formed Ag NPs were well dispersed and spherically shaped with an average diameter of 30–32 nm. The Ag 2 O NPs were not homogeneous but showed irregular shapes with an average diameter of 40–42 nm. Ag-1 showed antibacterial activity against selected Gram-positive (B acillus megaterium) and Gram-negative (P seudomonas Stutzeri) bacteria. The cytotoxicity of Ag-1 against MCF-7 cancer cells was also tested. [Display omitted] [ABSTRACT FROM AUTHOR]

Seven novel naphthalen-1-ylmethyl substituted silver N -heterocyclic carbene (Ag–NHC) complexes (1–7) were synthesized by the interaction of benzimidazolium salts with silver carbonate in dry dichloromethane at room temperature and characterized by means of spectroscopic methods and elemental analysis techniques. The Ag–NHC compounds were tested for their in vitro antibacterial and antifungal activity against Pseudomonas aeruginosa , Escherichia coli , Staphylococcus aureus , Enterococcus faecalis , Candida albicans and Candida tropicalis and showed high antimicrobial activities. The synthesized complexes, in particular, demonstrated better results against both fungi and gram-positive bacteria. [ABSTRACT FROM AUTHOR]

Slow and sustainable diffusion driven delivery of bio-active Ag+ from a dinuclear silver(I) complex derived from 2,6-bis(benzothiazole)-pyridine exhibits excellent antibacterial properties against S. epidermidis and A. baumanni. Another mononuclear Cu(II) complex with same ligand also demonstrated noticeable growth inhibition albeit to a relatively lesser extent. Two new coinage metal complexes, namely [Cu(bztpy)Cl 2 ] (1) and [Ag 2 (bztpy) 2 ](CF 3 SO 3) (2) (where bztpy = 2,6-bis(benzothiazole)-pyridine) have been synthesized and structurally characterized. The coordination geometry of 1 is distorted square pyramidal, while in case of the dinuclear complex 2 , the two crystallographically distinct Ag centers resides in a highly distorted trigonal coordination environment. In this structure the two ligands bind the metal centers in a way that results in a double helical pattern. Both complexes exert strong antimicrobial actions against Gram-positive and Gram-negative bacterial strain. The zone of bacterial clearance by complex 2 in SSTI (soft tissue and skin infection) model is found to be comparable to that by silver nitrate. For both types of pathogens, complex 2 inflicts superior growth inhibition compared to complex 1 under same experimental conditions. [ABSTRACT FROM AUTHOR]

A new asymmetric ligand, 5‐{3‐[5‐(4‐methylphenyl)‐1,3,4‐oxadiazol‐2‐yl]phenyl}‐2‐(pyridin‐3‐yl)‐1,3,4‐oxadiazole (L5), which contains two oxadiazole rings, was synthesized and characterized. The assembly of symmetric 2,5‐bis(pyridin‐3‐yl)‐1,3,4‐oxadiazole (L1) and asymmetric L5 with AgCO2CF3 in solution yielded two novel AgI complexes, namely catena‐poly[[di‐μ‐trifluoroacetato‐disilver(I)]‐bis[μ‐2,5‐bis(pyridin‐3‐yl)‐1,3,4‐oxadiazole]], [Ag2(C2F3O2)2(C12H8N4O)2]n or [Ag2(μ2‐O2CCF3)2(L1)2]n (1), and bis(μ3‐5‐{3‐[5‐(4‐methylphenyl)‐1,3,4‐oxadiazol‐2‐yl]phenyl}‐2‐(pyridin‐3‐yl)‐1,3,4‐oxadiazole)tetra‐μ3‐trifluoroacetato‐tetrasilver(I) dichloromethane monosolvate, [Ag4(C2F3O2)4(C22H15N5O2)2]·CH2Cl2 or [Ag2(μ3‐O2CCF3)2(L5)]2·CH2Cl2 (2). Complex 1 displays a one‐dimensional ring–chain motif, where dinuclear Ag2(CF3CO2)2 units alternate with Ag2(L1)2 macrocycles. This structure is different from previously reported Ag–L1 complexes with different anions. Complex 2 features a tetranuclear supramolecular macrocycle, in which each ligand adopts a tridentate coordination mode with the oxadiazole ring next to the p‐tolyl ring coordinated and that next to the pyridyl ring free. Two L5 ligands are bound to two Ag1 centres through two oxadiazole N and two pyridyl N atoms to form a macrocycle. The other two oxadiazole N atoms coordinate to the two Ag2 centres of the Ag2(O2CCF3)4 dimer. Each CF3CO2− anion adopts a μ3‐coordination mode, bridging the Ag1 and Ag2 centres to form a tetranuclear silver(I) complex. This study indicates that the donor ability of the bridging oxadiazole rings can be tuned by electron‐withdrawing and ‐donating substituents. The emission properties of ligands L1 and L5 and complexes 1 and 2 were also investigated in the solid state. [ABSTRACT FROM AUTHOR]

A novel silver complex [Ag(C12H9O5)2] was synthesized by the reaction of silver salt (AgNO3) and coumarin based ligand (ethyl-5-hydroxy-2-oxo-2H-Chromene-3-carboxylate) at room temperature. The synthesized complex was characterized by using different analytical techniques like melting point (mp), infrared (IR) spectroscopy, powder X-ray diffraction (PXRD), thermo gravimetric analysis (TGA), atomic absorption spectroscopy (AAS) and mass spectrometry (ESI-MS). Ligand showed activity with MIC 20 µg/mL, 15 µg/mL, 15 µg/mL for S. aurues, E. coli and S. typhi, respectively whereas MIC values of Ag-complex for above mentioned bacterial strains were found to be 15 µg/mL, 10 µg/mL, 10 µg/mL, respectively. Ligand could not inhibit the growth of B. Subtilis, P. auruginosa, MRSA but Ag-complex showed MIC 30 µg/mL, 25 µg/mL for B. Subtilis and P. auruginosa. It also remained ineffective against MRSA. [ABSTRACT FROM AUTHOR]

In the present work, the two‐dimensional (2D) polymer poly[[μ4‐2‐(4‐nitrobenzenesulfonamido)benzoato‐κ4O1:O1:O1′:N6]silver(I)] (AgL), [Ag(C13H9N2O6S)]n, was obtained from 2‐(4‐nitrobenzenesulfonamido)benzoic acid (HL), C13H10N2O6S. FT–IR, 1H and 13C{1H} NMR spectroscopic analyses were used to characterize both compounds. The crystal structures of HL and AgL were determined by single‐crystal X‐ray diffraction. In the structure of HL, O—H...O hydrogen bonds between neighbouring molecules result in the formation of dimers, while the silver(I) complex shows polymerization associated with the O atoms of three distinct deprotonated ligands (L−). Thus, the structure of the Ag complex can be considered as a coordination polymer consisting of a one‐dimensional linear chain, constructed by carboxylate bridging groups, running parallel to the b axis. Neighbouring polymeric chains are further bridged by Ag—C monohapto contacts, resulting in a 2D framework. Fingerprint analysis of the Hirshfeld surfaces show that O...H/H...O hydrogen bonds are responsible for the most significant contacts in the crystal packing of HL and AgL, followed by the H...H and O...C/C...O interactions. The Ag...Ag, Ag...O/O...Ag and Ag...C/C...Ag interactions in the Hirshfeld surface represent 12.1% of the total interactions in the crystal packing. Studies of the interactions of the compounds with human serum albumin (HSA) indicated that both HL and AgL interact with HSA. [ABSTRACT FROM AUTHOR]

Gliclazide, N-(4-Methyl Benzene Sulphonyl)-N-(3-azo bicycle (3,3,0-Oct-3-yl) urea trade name Diamicron, an oral hypoglycemic agent was used to synthesize its complex with Ag(I). The hypoglycemic activity of gliclazide was observed on experimental animals (dogs) and then compared with Ag Complex, using Folin-Wu method. Results reveals that the gliclazide Ag-Complex is more effective than that of parent drug. This blood sugar lowering effect of sulfonylureas seems to be related to the stimulation of insulin secretion. On the other hand many studies have strongly indicated the presence of long term or extra pancreatic action of sulfonylureas. The interesting observation on metal complex of oral sulfonylurea used as anti-diabetic agent for lowering blood sugar concentration may likely substantiates the use of these complex after extensive clinical studies. [ABSTRACT FROM AUTHOR]

Abstract Metal N-heterocyclic carbene (NHC) complexes have attracted considerable attention in biological fields for their potential applications in cancer and antimicrobial therapies. In this study, four new benzimidazole-based N-heterocyclic carbene salts (1a-d) and their silver (I) complexes (2a-d) were synthesized. All new compounds were characterized by elemental analysis, FT-IR, 1H NMR and, 13C NMR spectroscopy. Additionally, single crystal structural studies for complex 2d show that the benzene rings (C9 C14) and the central benzimidazole ring system make dihedral angles of 83.58(13)°. The Ag C l and Ag C single bond lengths are 2.3267(8) and 2.087(3) Å, respectively. The C Ag C l bond angle is 175.20(7)°. The prop-1-ene moiety attached at the second N-atom of benzimidazole is disordered at two set of sites with an occupancy ratio of 0.592(6): 0.408(6). There is one intramolecular hydrogen bond interaction between C22A-H22A ... N2. The salts and Ag-complexes were further evaluated for their in vitro anticancer activities against DU-145 human prostate cancer cells, MCF-7, MDA-MB-231 human breast cancer cells and L-929 non-cancer cell for 24 h, 48 h and 72 h using the MTT assay. The Ag(I) NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. The IC 50 s for all Ag(I) NHC complexes lower than 1 μM for 72 h time points on cancer cells. The results showed that complex 2d exhibited the highest activity against all cancer cell lines studied. Further, the complexes had relatively higher cytotoxicity to cancer cells than to non-cancer cell lines. Graphical abstract Image 1 Highlights • N-heterocyclic carbene ligands (NHC) and their Ag(I) complexes have been synthesized. • All the ligands and complexes were characterized by spectroscopic methods. • All compounds have been applied for the anticancer activity on MCF-7, MDA-MB-231 and DU-145 cancer cells. • The Ag(I) NHC complexes showed a dose and time-dependent cytotoxic activity against all cell lines. [ABSTRACT FROM AUTHOR]

Five new silver(I) complexes were synthesized with mixed ligands of thiosemicarbazone derivatives and diphenyl(p-tolyl)phosphine in search of new biologically active compounds. A CHN elemental analysis, powder X-ray diffraction (PXRD) data and several spectroscopic techniques such as Fourier-transform infrared spectroscopy, energy-dispersive X-ray, 1H, 13C, and 31P{1H} NMR were performed to elucidate the structure of these complexes. Elemental analysis suggested that the stoichiometry of the complexes formed by the reaction of silver nitrate with thiosemicarbazone in the presence of (p-tolyl)PPh2 was indeed 1:2:1 molar ratio. The silver ions were discovered to be coordinated to the sulfur of thiosemicarbazone and phosphorus of (p-tolyl)PPh2, having a tetrahedral geometry based on the spectroscopic data obtained. The PXRD patterns were studied to see the degree of crystallinity of the complexes. The in vitro antiproliferative activity of these complexes was investigated toward the MDA-MB-231 and MCF-7 breast cancer cell lines, as well as the HT-29 colon cancer cell line, which yielded IC50 values in low micromolar range. The antiplasmodial activity of these complexes was also examined against chloroquine-resistant Plasmodium falciparum parasite which demonstrated good activity and further tested for their selectivity index. [ABSTRACT FROM AUTHOR]

• The PMB-AZAP/Ag 2 O was first applied to the carboxylative cyclization of propargylic alcohols with CO 2 and achieved high yield (>99 %) and selectivity (>99 %) of the α-alkylidene cyclic carbonates at room temperature and atmospheric pressure. • The reaction mechanism revealed that PMB-AZAP and Ag 2 O formed a silver complex PMB-AZAP-Ag during the reaction, which was a key active species for catalytic carboxylative cyclization. • The PMB-AZAP/Ag 2 O was also applied for the one-pot reaction of propargylic alcohol, CO 2 and CH 3 OH, affording the β-carbonyl carbonate with high yield of 80 %. The utilization of carbon dioxide (CO 2) to synthesize various chemicals is of great importance. Herein, various azaphosphatranes and silver salts were applied to catalyze the carboxylative cyclization of CO 2 and propargylic alcohols to prepare α-methylene cyclic carbonates. The influences of catalyst structures, solvents and reaction parameters on catalytic performance were systematically studied. The combination of tris(4-methoxybenzyl) azaphosphatranes (PMB-AZAP) and Ag 2 O with molar ratio of 0.5:1 gave α-methylene cyclic carbonate in the yield of >99 % at room temperature. Meanwhile, other azaphosphatranes (i -Bu-AZAP, Me-AZAP) gave the product in slightly lower yields. The mechanism exploration revealed that PMB-AZAP and Ag 2 O formed a silver complex PMB-AZAP-Ag during the reaction, which could synergistically catalyze carboxylative cyclization reaction with PMB-AZAP, resulting in a high product yield. In contrast, AgCl or AgNO 3 couldn't react with PMB-AZAP to form silver complexes, and the corresponding catalytic system had no activity. The difference of the catalytic performance indicated that PMB-AZAP-Ag was a key active species for the carboxylative cyclization reaction. The in situ NMR studies concretely demonstrated that PMB-AZAP could activate propargylic alcohols through hydrogen bonding. Furthermore, the catalytic system had good substrate generality. The PMB-AZAP/Ag 2 O was also applied for the one-pot reaction of propargylic alcohol, CO 2 and CH 3 OH, affording the β-carbonyl carbonate with yield of 80 % at CH 3 OH/propargylic alcohols ratio of 20:1. [Display omitted] [ABSTRACT FROM AUTHOR]

A new silver complex [Ag(C11H8O3)2]NO3 was synthesized by the reaction of silver nitrateand coumarin based ligand (3-acetyl-2H-chromene-2-one) through solution method. The product was characterized using different analytical techniques like melting point, Infrared spectroscopy, Raman spectroscopy, powder X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, atomic absorption spectroscopy and mass spectrometry. An antibacterial study of the complex was also studied for its possible use in medical treatment.

The title compound, [Ag(qPyr)2]CF3SO3 where qPyr = 1-(quinoline-2-ylmethylene)aminopyrene, C26H16N2, was synthesized from a reaction of silver trifluoromethanesulfonate and qPyr in dichloromethane–methanol mixed media. In this design, the qPyr ligand was chosen for its characteristic excitation and emission profiles, which could enable the tracking of the silver complex within biological targets. The AgI atom resides in a distorted tetrahedral N4 coordination sphere. Analysis of the packing pattern revealed significant intra- and intermolecular π–π stacking interactions between the [Ag(qPyr)2]+ cations. In addition, a weak C—H...O hydrogen bond consolidates the packing between cations and anions.

In the title compound, [Ag2(C3H6N2S)4(C18H15P)2](C2H3O2)2·[Ag(C2H3O2)(C3H6N2S)(C18H15P)2]2·2C2H3N·4H2O, the AgI ion in the mononuclear neutral complex exhibits a distorted tetrahedral environment with coordination by two P atoms from triphenylphosphane (PPh3) ligands, one S atom of an imidazolidine-2-thione (etu) ligand and one O atom of an acetate anion. The binuclear cationic complex comprises two inversion-related [Ag(C3H6N2S)2(C18H15P)] units with AgI ions bridged by two S atoms from etu ligands forming a four-membered Ag–S–Ag–S ring. Each AgI ion is coordinated by a P atom of a PPh3 ligand, two S atoms of bridging etu ligands and the terminal S atom of an etu ligand in a distorted tetrahedral environment. In the crystal, the mononuclear complex is linked to lattice water molecules through O—H...O and N—H...O hydrogen bonds, forming a chain along [100]. In addition, the binuclear complex molecules are connected to acetate anions and lattice water molecules via O—H...O, N—H...O and O—H...S hydrogen bonds, also along [100].

Purpose: The problem of infectious diseases and drug resistance is becoming increasingly important worldwide. Silver is extensively used as an anti-infective agent, but it has significant toxic side effects. In this regard, it is topical to develop new silver compounds with high biological activity and low toxicity. This work is aimed to study DNA damage and chromosomal aberrations in blood cells under the influence of new silver-based compound of general formula C6H19Ag2N4LiO6S2, with antiviral activity. Methods: The comet assay was applied for the genotoxic affects assessment on mice blood leukocytes. DNA damage was determined bases on the percentage of DNA in a comet tail (tail DNA), under the influence of silver complex in different concentrations. Genotoxic effect of the tested substance on the somatic cells was determined by chromosomal aberration test of bone marrow cells of mice. Results: In the course of the experiments, no essential changes in the level of DNA damage in the cells were found, even at highest concentrations. The administration of the substance in doses up to 2.5 g/kg in mice did not cause any increase in the frequency of chromosomal aberration in bone marrow cells. Conclusion: Taking into account known silver drug genotoxic properties, the use of a given complexed silver compound has possible great advantages for potential applications in the treatment of infectious diseases.

Graphical abstract Highlights • Novel N-heterocyclic carbene silver(I) complexes. • Elemental analysis, FT-IR, 1H NMR and 13C NMR and X-ray crystallography techniques. • Anticancer activities on prostate and breast cancer cells and L-929 normal cells. • Selectivity for human cancer cells and non-cancer cells. Abstract In this study, we synthesized four novel unsymmetrically substituted NHC ligands (1a-d) and their Ag(I) complexes (2a-d). All new compounds were characterized using elemental analysis, FT-IR, 1H NMR, and 13C NMR spectroscopy and X-ray crystallography. The molecular structure of complex 2d was elucidated through single crystal X-ray diffraction analyses. Single crystal structural studies for complex 2d show that the benzene rings (C9–C14) and the central benzimidazole ring system make dihedral angles of 85.65(11)°. The Ag–C l and Ag–C single bond lengths are 2.3553(7) and 2.096(2) Å, respectively. The C–Ag–C l bond angle is 168.27(7)°. Both salts and complexes were tested for their anti-cancer potential against three human cancer cell lines (DU-145, MCF-7, and MDA-MB-231) and non-cancer cells adipose from mouse (L-929) for 24 h, 48 h and 72 h using the MTT assays. However, the Ag(I)–NHC complexes (2a-d) showed a dose and time-dependent cytotoxic activity against all cell lines. MDA-MB-231 human breast carcinoma cells were the most sensitive to the Ag(I)–NHC complex displaying IC 50 lower than 1 μM all time points. Further, the IC 50 s for Ag(I)–NHC were higher in non-cancer cells, suggesting that complexes possessed noteworthy selectivity for human cancer cells. [ABSTRACT FROM AUTHOR]

Abstract Two new coordination polymers {[Ag(bpe)] 4 V 6 O 17 } n (1) and {[Ag(bpe)] 10 V 14 O 40 } n ∙3nH 2 O (2) (bpe = 1,2-di(4-pyridyl)ethylene) had been synthesized by hydrothermal methods, and characterized by elemental analysis, IR, UV–vis, TG, XRD and single-crystal X-ray diffraction. Structural analysis revealed that they both consist of {VO 4 }-based chain-like polyanions and {Ag-bpe} cationic units. The structural differences of 1–2 clearly showed that the polyoxovanadates are sensitive to the dosages of NH 4 VO 3 source in synthesis reaction. The aromatic π...π stacking and Ag...Ag weak interactions among {Ag-bpe} cationic units contribute the significant effect on the stability of 3D crystal structures. The catalytic properties of the synthesized crystals were tested. It was found that the photochemical degradation of MB can reach 74.2% in 90 min by using 1 as catalyst. Graphical abstract Two Ag-ligand modified vandates had been synthesized and characterized, which the inorganic moieties present chain-like {VO 4 } ∞ arrangement consisting of four/five-membered {VO 4 } rings bridged by {VO 4 } 2 subunits via oxygen-shared modes. fx1 Highlights • Two new coordination polymers have been synthesized and characterized. • The structures of crystals are stabilized by weak π...π and Ag...Ag interactions. • The formation of V-O clusters is senstitive to the reaction condition. [ABSTRACT FROM AUTHOR]

Graphical abstract The silver(II) complexes were obtained by reaction of five Ag(I) salts (hexafluoroantimonate, trifluoromethanesulfonate, 4-toluenesulfonate, heptafluorobutyrate and nitrate) with a functionalized N 6 O 2 macrocyclic ligand and characterized by IR, elemental analysis, 1H NMR, 13C NMR and X-ray determination. Their photoluminescent properties, thermal analysis and biological activity were also studied. Abstract The reactions between a tri-cyanoethyl functionalized 17-membered macrocyclic compound (L) with five Ag(I) salts (hexafluoroantimonate, trifluoromethanesulfonate, 4-toluenesulfonate, heptafluorobutyrate and nitrate) led to the formation of [AgL](SbF 6) (1), [AgL](SO 3 CF 3) (2), [AgL](O 2 C 4 F 7) (3), [AgL](SO 3 PhCH 3) (4), and [AgL](NO 3) (5), respectively. Complexes 1 – 5 were characterized by elemental analysis, 1H NMR, TG-DTA, TG-DTG and IR spectroscopies, moreover, by single crystal X-ray diffraction. In 1 – 5 , the structures show three kinds of coordination environments of silver ions: three-coordinated in 1 – 3 , four-coordinated in 4 and five-coordinated in 5. The photoluminescent properties, thermal analysis and biological activity of these silver complexes were also studied. [ABSTRACT FROM AUTHOR]

Abstract The addition of an aqueous solution of silver nitrate to an aqueous acetonitrile solution of 2,6-pyridinedicarboxylic acid (2,6-pydcH 2) affords a new complex, {[Ag(2,6-pydcH)(2,6-pydcH 2)]·2H 2 O}, 1, at ambient conditions. The complex 1 was structurally characterized by means of elemental analysis, FT-IR, UV–Visible, NMR techniques and thermal gravimetric analysis. The structure of 1 was determined by single crystal X-ray diffraction. The asymmetric unit of complex 1 consists of one Ag(I) center bonded to one 2,6-pydcH 2 and one deprotonated 2,6-pydcH with two water molecules acting as guest molecules connecting the discrete molecules of the complex 1. The Ag(I) atom adopts a distorted tetrahedral geometry. The discrete units of complex 1 extend along the b-axis creating 1D-chain via hydrogen bonds. The hydrogen bonds and π-π stacking interactions extend the structure of 1 to 3D-network structure accommodating the guest water molecules. The cytotoxic impact of 1 on the viability of MCF-7 cells was examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay exhibiting great restraint action to MCF-7 cells. Furthermore, the catalytic degradation performance of 1 towards methylene blue dye (MB) in presence of H 2 O 2 as oxidant had been also discussed. The luminescence spectra in the solid state of the 2,6-pydcaH 2 and the complex 1 were discussed. Graphical abstract Image 1 Highlights • The complex {[Ag(2,6-pydcH)(2,6-pydcH 2)]·2H 2 O} , 1 was obtained. • The structure was characterized by spectroscopic and single-crystal X-ray diffraction. • The catalytic behavior of 1 was utilized for degradation of MB dye. • The cytotoxic impact of 1 on the viability of MCF-7 cells was also examined. • The luminescence spectra of the 2,6-pydcaH 2 and 1 were discussed. [ABSTRACT FROM AUTHOR]

Background/Aims: The ubiquitin proteasome system (UPS) is responsible for the degradation of most intracellular proteins, and proteasomal deubiquitinases (DUBs) have recently been highlighted as novel anticancer targets. It is well documented that copper complexes can inhibit UPS function through targeting both 20S proteasome and proteasomal DUBs. The antineoplastic activities of silver complexes have received much attention, but the exact mechanisms are not fully elucidated. In this study, we aim to investigate the effects of a novel silver complex [Ag(S2CN(C2H5)2)]6 (AgDT) on UPS function and its anticancer potential in non-small cell lung cancer (NSCLC). Methods: Cell viability assay (i.e., the MTS assay) and flow cytometry assay were used to analyze the cell viability and apoptosis. Proteasome inhibition was measured using 20S proteasome activity assay and 19S proteasomal DUBs activity assay. Western blot analysis and immunohistochemistry were performed to detect protein levels. The in vivo antitumor activity of AgDT was assessed with nude xenografts. Results: Silver ions, alone or in combination with disulfiram (DSF), induced UPS inhibition in NSCLC cells mainly through inhibition of proteasomal DUBs activities. Silver complex AgDT triggered intracellular accumulation of ubiquitinated proteins, and prevented the degradation of surrogate substrate GFPu. Mechanistically, AgDT potently inhibited the activities of proteasomal DUBs USP14 and UCHL5, without altering the 20S proteasome peptidases. Moreover, AgDT induced apoptosis in NSCLC cells and significantly inhibited tumor growth in xenografts. Conclusion: Our findings suggest that silver complex AgDT is a novel metal-based proteasomal DUBs inhibitor, and pharmacologic inhibition of USP14 and UCHL5 could prove to be an effective therapeutic strategy for NSCLC. [ABSTRACT FROM AUTHOR]

Abstract Silver has been used for numerous medical conditions for centuries, however, most of the current clinical silver agents all have their own disadvantages limiting the clinical usefulness. Therefore, employing ligands that can strongly coordinate to the active Ag(I) ions is essential. In recent years, systematic discovery and development of silver complex yielded a large number of promising antibacterial, antifungal and anticancer compounds. They were primarily classified into five classes: Ag(I)-NHC complex, Ag(I)-carboxylate complex, Ag(I)-N-ligand complex, Ag(I)-P-ligand complex and Ag(I)-mixed ligand complex. Most of them showed enhanced activities than their pro-ligands, and some even exhibited exciting biological results better than the first line treatments in clinic. This review focuses on the development, application and chemical synthesis of pharmaceutical active silver complexes. Then we discuss the application prospect and development of active silver complex. Graphical abstract Image 1 Highlights • Silver(I) complexes were primarily classified into five structural classes. • Most showed enhanced bioactivities than their pro-ligands. • Some exhibited exciting biological results better than the first line treatments. • The enlargement of ligands, the mechanism of action need further research. • The selectivity on the target and the in vivo tests should be focused on. [ABSTRACT FROM AUTHOR]

A benzimidazolium salt bearing hydroxyethyl group, 1a and a new series of zwitterionic sulphonated benzimidazolium salts, 1b – e were reacted with Ag 2 O to produce Ag(I)- N -heterocyclic carbene (NHC) complexes, 2a – e respectively. Synthesised silver(I)- N -heterocyclic carbene complexes were fully characterised by 1 H and 13 C NMR, elemental analysis and HRMS spectroscopic methods. Anti-cancer potential of both NHC salts and complexes were tested and the IC 50 values of these NHC salts and complexes were determined by a proliferation BrdU enzyme-linked immunosorbent assay (ELISA) against HeLa (Human cervix carcinoma), HT29 (human adenocarcinoma) and L929 (mouse fibroblast) cell lines. The IC 50 values are in the range of 11 ± 1–126 ± 3 μM show that all new Ag(I)-NHC complexes especially complex 2b demonstrated remarkable cytotoxic activity against HeLa, HT29 and L929 while 1a – e NHC salts are found to be inactive against HeLa, HT29 and L929. Also, the high IC 50 value of complex 2b against L929 cells can be interpreted high selectivity against healthy cells. This complex has been highlighted as new types of metalodrug. [ABSTRACT FROM AUTHOR]

4-[(2-Diphenylphosphanylphenyl)methyleneamino]benzoic acid (HL) is obtained by the condensation of o-diphenylphosphinobenzaldehyde and p-aminobenzoic acid. The reaction of AgNO3 and HL affords complex [Ag2L2] · H2O (I). The structure of complex I is determined by X-ray structure analysis (CIF file CCDC 1575064), and its reflectance and luminescence spectra are studied. Binuclear complex I is a cyclic molecule in which each of two silver(I) atoms coordinates one phosphorus atom and one oxygen atom of two bridging anions L. Compound I is characterized by emission in a range of 430-740 nm at λexc = 340 and 395 nm. [ABSTRACT FROM AUTHOR]

Our group has developed a series of molecular electrocatalysts for hydrogen generation based on triazenido-metal complexes (such as cobalt, copper, etc.). In this paper, we present the electrocatalytic performance of a new dinuclear silver complex, [Ag2(L)2], formed by reaction of the triazenido ligand, 1-[(2-carboxyethyl)benzene]-3-[benzimidazole]triazene (HL) with AgNO3. The electrocatalytic systems based on this silver complex can afford 91.23 and 473 moles of hydrogen per mole of catalyst per hour (mol H2/mol catalyst/h) from acetic acid at overpotential (OP) of 991.6 mV and an aqueous buffer at an OP of 837.6 mV, respectively. Electrochemical investigations show both the silver center and the triazenido ligand, HL, play important roles in determining the catalytic activities of the electrocatalytic system. Additionally, the triazenido ligand (HL) can serve as a fluorescent sensor for Ag+. [ABSTRACT FROM AUTHOR]