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Sexual behavior in female rats varies depending on sexual history and the combination of ovarian hormones administered to induce receptivity. Experiment 1 tested whether paced mating behavior differed in sexually experienced rats when receptivity was induced with sequential estradiol benzoate (EB) and progesterone (P) or EB-Alone. Rats gained paced mating experience under EB/P (10 μg EB 48 hr + 1 mg P 4–6 hr before mating) and then were primed with EB-Alone (2 μg EB for 6 days). Rats primed with EB-Alone were fully receptive but returned to the male more slowly, spent less time with the male, had longer interintromission intervals, showed fewer proceptive behaviors and more rejection behaviors, and had significantly longer test durations compared to when rats were primed with EB/P. Experiment 2 tested whether sexual experience-induced changes to paced mating behavior occur under both EB/P and EB-Alone hormone priming regimens. Rats received EB/P or EB-Alone prior to four paced mating tests. With sexual experience under either hormone regimen, rats showed shorter contact-return latencies to intromission, shorter interintromission intervals, and more proceptive behaviors. However, relative to EB/P-primed rats, EB-Alone-primed rats exited the male compartment more frequently after mounts and intromissions, spent less time with the male, had longer interintromission intervals, displayed fewer proceptive behaviors and more rejection behaviors, and had longer test durations, indicating lower sexual motivation. Collectively, these data illustrate that experience-enhanced paced mating behavior occurs with either EB/P or EB-Alone priming, but progesterone further facilitates mating behavior. [ABSTRACT FROM AUTHOR]

Introduction: The Faking Orgasm Scale for Women (FOS) was developed to explore the motivations behind women's self-reported instances of faking orgasm during oral sex and sexual intercourse. In a recent study, a Hungarian version of the FOS was developed, confirming the same factor structure as the original American version, consisting of four factors across two subscales. Methods: The current study aimed to develop and validate a brief Hungarian FOS. Factor analysis was conducted with data from 2220 women (mean age = 24.4, SD = 7.48 years). The Item Response Theory (IRT) analysis indicated that retaining four-four scales, each comprising of three items was the optimal solution for the revised shorter version. Validation involved 768 women (mean age = 22.6, SD = 4.54 years) completing a questionnaire package, including the Hungarian Short Form of Reasons for Having Sex Questionnaire (YSEX?-HSF) and Women's Sexual Working Models Scale (WSWMS). Results: The results suggest that the Hungarian 24-item FOS, with its four scales within each of the two sub-scales, provides a reliable and valid measurement of motives for faking orgasm in women. The different reasons behind faking orgasm are associated with different sexual working patterns and sexual motivations. Furthermore, women who reported faking orgasms reported significantly higher levels of sexual distancing and perceived lower care from their partners compared to women who reported not faking orgasms. Women who reported faking orgasm were also more likely to engage in sexual activities to attain personal goals and cope with emotional stress. Discussion: The FOS-24 offers both practitioners and researchers a concise and useful instrument for the assessment of faking orgasms. [ABSTRACT FROM AUTHOR]

Background Motor cortex excitability may represent the neuronal endpoint of motivational processes and was shown to be modulated by both sexual arousal and deceptive behavior. Aim This is the first study to investigate the influence of lying and sex in heterosexual women and men based on motor-evoked potentials (MEPs) measured while viewing sexually arousing pictures. Methods Sixteen heterosexual couples were shown 360 trials consisting of pictures displaying both almost naked females and males and neutral control images. In a subsequent forced-choice question about wanting to see the respective pictures fully naked, they were instructed to either answer in agreement with or opposite to their sexual preference. Participants went through 2 blocks of answering truthfully and 2 blocks of lying, with these 4 blocks being shown in a randomized alternating order. Outcomes To measure cortical excitability, MEPs were used, evoked by single transcranial magnetic stimulation pulses between image presentation and response. Results In normalized MEPs, women and men showed higher amplitudes for preferred over non-preferred sexual stimuli, but only on a descriptive level. Planned contrasts showed higher non-normalized MEPs for lying in all picture categories. Direct comparisons to a preliminary study showed overall lower effect sizes. Clinical Implications Both sexes tend to show higher MEPs in response to their sexually preferred stimuli. MEPs are not stable markers for willful volitionally controlled deception although lying does increase cortical excitability. The present experimental design does not seem valid enough to serve as a diagnostic marker for sexual preference or paraphilia and malingering. Strengths and Limitations This is the first study investigating whether sexual motivational stimuli modulate MEPs in women, while also examining the influence of lying for both sexes. The sample was too small for some found effects to be significant. Also, the experimental setup may have been less suited for female participants in comparison to male ones. Conclusion The operationalization of sexual motivation via MEPs seems to highly depend on different experimental factors including the sex of the participants, induced motivation, and lying. [ABSTRACT FROM AUTHOR]

Our meta-analysis on gender differences in sex drive found a stronger sex drive in men compared to women (Frankenbach et al., 2022). Conley and Yang (2024) criticized how we interpreted the findings and provided suggestions regarding the origins of these gender differences, an undertaking that we had refrained from doing in our original work. We concur with several important points made by Conley and Yang (2024): (a) women's sexual experiences are generally more negative than men's, which could partly explain why men report more sex drive; (b) lack of statistical moderation by some sociocultural variables does not imply that the sex drives of men and women are generally unaffected by the social environment; and (c) gender differences in sexuality are likely smaller than they are often portrayed in research, and that the practical impact of this difference is largely unknown. Still, we reject other assertions made by Conley and Yang (2024): (a) we did not frame our findings in support of the view that gender differences in sex drive are determined by biology, (b) we did not conflate response bias with sociocultural biases more broadly, and (c) we did not fail to incorporate and consider gendered cultural messages about sexuality in our methods and discussion. We make several suggestions about future research on these matters. Public Significance Statement: This article is part of a scientific discussion about the meaning of gender differences in sex drive. The initial research summary (Frankenbach et al., 2022) that prompted this discussion found a stronger sex drive in men than women but did not investigate the origins of this gender difference nor did it argue that men's sex drive is stronger due to innate biological differences. The present discussion highlighted gaps in knowledge about the causes of gender differences in sex drive. Such complex questions require more future attention in dedicated research. [ABSTRACT FROM AUTHOR]

IntroductionThe Faking Orgasm Scale for Women (FOS) was developed to explore the motivations behind women’s self-reported instances of faking orgasm during oral sex and sexual intercourse. In a recent study, a Hungarian version of the FOS was developed, confirming the same factor structure as the original American version, consisting of four factors across two subscales.MethodsThe current study aimed to develop and validate a brief Hungarian FOS. Factor analysis was conducted with data from 2220 women (mean age = 24.4, SD = 7.48 years). The Item Response Theory (IRT) analysis indicated that retaining four-four scales, each comprising of three items was the optimal solution for the revised shorter version. Validation involved 768 women (mean age = 22.6, SD = 4.54 years) completing a questionnaire package, including the Hungarian Short Form of Reasons for Having Sex Questionnaire (YSEX?-HSF) and Women’s Sexual Working Models Scale (WSWMS).ResultsThe results suggest that the Hungarian 24-item FOS, with its four scales within each of the two sub-scales, provides a reliable and valid measurement of motives for faking orgasm in women. The different reasons behind faking orgasm are associated with different sexual working patterns and sexual motivations. Furthermore, women who reported faking orgasms reported significantly higher levels of sexual distancing and perceived lower care from their partners compared to women who reported not faking orgasms. Women who reported faking orgasm were also more likely to engage in sexual activities to attain personal goals and cope with emotional stress.DiscussionThe FOS-24 offers both practitioners and researchers a concise and useful instrument for the assessment of faking orgasms.

Rationale: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses. Objective: The present study examined the acute, subchronic, and chronic dose–response effects of CAB and a derivative dimethylcabergoline (DMC) which acts as an antagonist instead of agonist at 5-HT 2B receptors, on appetitive and consummatory sexual behaviors of male rats. Methods: CAB (0, 0.03, 0.15, or 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 68 days. Sexual behavior was tested every 4 days during this period for a total of 16 trials. On the 17th trial, rats were administered their dose of CAB, and 4 h after were overdosed with sodium pentobarbital, perfused intracardially, and their brains processed for Fos immunohistochemistry. DMC (0, 0.03, 0.15, 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 36 days. Sexual behavior was tested every 4 days for a total of 9 trials. Results: CAB increased anticipatory level changes, intromissions, and ejaculations significantly across all timepoints, with the medium and high doses being most potent. The medium and high doses also increased Fos protein significantly within the medial preoptic area, whereas in the nucleus accumbens shell, the low and medium doses decreased Fos protein but the high dose increased it significantly from control. Similar to CAB, the medium and high doses of DMC increased the number of ejaculations significantly. Rats in all drug dose groups appeared healthy for the duration of the experiments. Conclusions: Both CAB and DMC facilitate ejaculations, and CAB further facilitates measures of anticipatory sexual motivation and intromissions. These data suggest that both could be used as treatments for sexual arousal disorders and ejaculation/orgasm disorders with little or no untoward side effects at low doses. [ABSTRACT FROM AUTHOR]

Hypoactive sexual desire disorder (HSDD) in men, characterized by chronically low sexual desire, is associated with poor sexual well-being, such as lower sexual satisfaction and higher sexual distress. Additionally, despite their low desire, men with HSDD often report wanting sexual intimacy and validation within their sexual lives/relationships. Studies that apply self-determination theory to sexual relationships demonstrate that adopting more autonomous (e.g., engaging in sex for its inherent pleasure) and less controlled (e.g., engaging in sex for some external reward or consequence) motives for engaging in sex is associated with greater sexual well-being for both members of the couple. Given that autonomous motivation in relationships is associated with intimacy and sexual satisfaction, and lower sexual distress, having sex for autonomous reasons may allow men with HSDD and their partners to feel more sexually intimate despite their lower sexual desire, whereas having sex for controlled reasons may hinder sexual intimacy and satisfaction and augment sexual distress. In this dyadic cross-sectional study, we examined the associations between types of sexual motivation and sexual intimacy, sexual satisfaction, and sexual distress for men with HSDD and their partners (n = 64 couples). Men with HSDD who reported having sex for more autonomous reasons reported more sexual satisfaction and both partners reported more sexual intimacy. Men with HSDD who had sex for more controlled reasons had partners who felt less sexual intimacy and satisfaction, and both partners were more sexually distressed. Promoting autonomous sexual motivation and decreasing controlled motivation may help couples navigating HSDD to feel closer in their relationship, more sexually satisfied, and less sexually distressed. [ABSTRACT FROM AUTHOR]

In the presented review, we analyzed the physiology of male sexual arousal and its relation to the motivational aspects of this behavior. We highlighted the distinction between these processes based on observable physiological and behavioral parameters. Thus, we proposed the experimentally applicable differentiation between sexual arousal (SA) and sexual motivation (SM). We propose to define sexual arousal as an overall autonomic nervous system response leading to penile erection, triggered selectively by specific sexual cues. These autonomic processes include both spinal and supraspinal neuronal networks, activated by sensory pathways including information from sexual partner and sexual context, as well as external and internal genital organs. To avoid misinterpretation of experimental data, we also propose to precise the term "sexual motivation" as all actions performed by the individual that increase the probability of sexual interactions or increase the probability of exposition to sexual context cues. Neuronal structures such as the amygdala, bed nucleus of stria terminalis, hypothalamus, nucleus raphe, periaqueductal gray, and nucleus paragigantocellularis play crucial roles in controlling the level of arousal and regulating peripheral responses via specific autonomic effectors. On the highest level of CNS, the activity of cortical structures involved in the regulation of the autonomic nervous system, such as the insula and anterior cingulate cortex, can visualize an elevated level of SA in both animal and human brains. From a preclinical perspective, we underlie the usefulness of the noncontact erection test (NCE) procedure in understanding factors influencing sexual arousal, including studies of sexual preference in animal models. Taken together results obtained by different methods, we wanted to focus attention on neurophysiological aspects that are distinctly related to sexual arousal and can be used as an objective parameter, leading to higher translational transparency between basic, preclinical, and clinical studies. [ABSTRACT FROM AUTHOR]

This document is an editorial published in Frontiers in Neuroscience in May 2024. It discusses the research on male sexual behavior and sexual dysfunctions, focusing on the central nervous system (CNS) and spinal cord modulation. The editorial highlights three articles that address the regulation of male sexual behavior at the functional and neurochemical levels. The authors also explore the concepts of sexual motivation, sexual reward, premature ejaculation, sexual arousal, endocannabinoids, selective serotonin reuptake inhibitors, and brain sexual circuits. The goal of the editorial is to stimulate a productive conversation and advance knowledge in the field of male sexual behavior. [Extracted from the article]

The generalized social concern with sexual harassment and nonconsensual sex makes it imperative to incorporate notions of consent in any analysis of human sexual interactions. Such interactions follow an ordered sequence of events, starting with the perception of a sexual incentive, followed by an approach to it, genital interaction, and eventually orgasm. Consent from the partner is needed at every stage. At some points in this chain of events, the individuals involved make cognitive evaluations of the context and predictions of the likelihood for obtaining consent for proceeding to the next phase. Processes such as communication of consent or lack thereof, sexual decision making, and interpretation of cues emitted by the partner are decisive. Increased sexual motivation may influence these processes. However, available data make it possible to ascertain that enhanced motivation has no, or at most minor, effects, thereby invalidating the old assumption that heightened sexual motivation leads to impaired control. [ABSTRACT FROM AUTHOR]

On the basis that the literature shows that most of the serial murders are committed by men and with sexual motivation, the research is a preliminary approach which aims to approach the cultural influence on the sexual motivation of serial killers. Eighty-six cases of serial murders with male perpetrators from different countries have been analyzed, committed between 1900 and 2020. The variables evaluated are related to the serial offender, victimology, modus operandi, sexual motivation typology and the actions related to such classification. In indulgence countries, pre mortem sexual acts (44.20%), interference with the victim's body (36.0%) and mutilation (27.90%) are the most common; the same occurs in restrictive countries, although in a lower percentage, with mutilation 7.0% being the only statistically significant variable (X² = 0.034). Direct-sadistic motivation is the most present, being 52.30% in indulgence countries and 18.60% in restrictive countries, there being a significant relationship (X² = 0.026). There is a partial influence of culture on modus operandi and sexual motivation according to the higher or lesser presence of social norms and how they influence the individual's decision making. [ABSTRACT FROM AUTHOR]

Sexual motivation is an abstract concept referring to the mechanisms determining the responsivity to sexually relevant stimuli. This responsivity determines the likelihood of producing a sexual response and the intensity of that response. Both responsivity to stimuli and the likelihood of making a response as well as the intensity of response are characteristics of an individual. Therefore, we need to assume that the concept of sexual motivation materializes in physiological mechanisms within the individual. The aim of the present communication is to analyze the requisites for the endeavor to materialize sexual motivation. The first requisite is to provide an operational definition, making the concept quantifiable. We show that parameters of copulatory behavior are inappropriate. We argue that the intensity of sexual approach behaviors provides the best estimate of sexual motivation in nonhuman animals, whereas the magnitude of genital responses is an exquisite indicator of human sexual motivation. Having assured how to quantify sexual motivation, we can then proceed to the search for physiological or neurobiological underpinnings. In fact, sexual motivation only manifests itself in animals exposed to appropriate amounts of gonadal hormones. In female rats, the estrogen receptor α in the ventrolateral part of the ventromedial nucleus of the hypothalamus is necessary for the expression of sexual approach behaviors. In male rats, androgen receptors within the medial preoptic area are crucial. Thus, in rats sexual motivation can be localized to specific brain structures, and even to specific cells within these structures. In humans, it is not even known if sexual motivation is materialized in the brain or in peripheral structures. Substantial efforts have been made to determine the relationship between the activity of neurotransmitters and the intensity of sexual motivation, particularly in rodents. The results of this effort have been meager. Likewise, efforts of finding drugs to stimulate sexual motivation, particularly in women complaining of low sexual desire, have produced dismal results. In sum, it appears that the abstract concept of sexual motivation can be reliably quantified, and the neurobiological bases can be described in non-human animals. In humans, objective quantification is feasible, but the neurobiological substrate remains enigmatic. [ABSTRACT FROM AUTHOR]

In the presented review, we analyzed the physiology of male sexual arousal and its relation to the motivational aspects of this behavior. We highlighted the distinction between these processes based on observable physiological and behavioral parameters. Thus, we proposed the experimentally applicable differentiation between sexual arousal (SA) and sexual motivation (SM). We propose to define sexual arousal as an overall autonomic nervous system response leading to penile erection, triggered selectively by specific sexual cues. These autonomic processes include both spinal and supraspinal neuronal networks, activated by sensory pathways including information from sexual partner and sexual context, as well as external and internal genital organs. To avoid misinterpretation of experimental data, we also propose to precise the term “sexual motivation” as all actions performed by the individual that increase the probability of sexual interactions or increase the probability of exposition to sexual context cues. Neuronal structures such as the amygdala, bed nucleus of stria terminalis, hypothalamus, nucleus raphe, periaqueductal gray, and nucleus paragigantocellularis play crucial roles in controlling the level of arousal and regulating peripheral responses via specific autonomic effectors. On the highest level of CNS, the activity of cortical structures involved in the regulation of the autonomic nervous system, such as the insula and anterior cingulate cortex, can visualize an elevated level of SA in both animal and human brains. From a preclinical perspective, we underlie the usefulness of the non-contact erection test (NCE) procedure in understanding factors influencing sexual arousal, including studies of sexual preference in animal models. Taken together results obtained by different methods, we wanted to focus attention on neurophysiological aspects that are distinctly related to sexual arousal and can be used as an objective parameter, leading to higher translational transparency between basic, preclinical, and clinical studies.

IntroductionDifferent techniques have been used to identify the brain regions that control sexual motivation and sexual behavior. However, the influence of sexual experience on the activation of these brain regions in the same subject is unknown. Using manganese-enhanced magnetic resonance imaging (MEMRI), we analyzed the activation of brain regions in the sexual incentive motivation (SIM) and the partner preference PP (tests) on weeks 1, 5, and 10 in male rats tested for 10 weeks. AIM. In experiment 1, we analyzed the possible toxic effects of 16 mg/kg of MnCl2 on male sexual behavior, running wheel, and motor execution. In experiment 2, subjects were tested for SIM and PP using MEMRI.MethodsIn both experiments, a dose of 16 mg/kg (s.c) of chloride manganese (MnCl2) was administered 24 h before subjects were tested and placed immediately thereafter in a 7-Tesla Bruker scanner.ResultsIn experiment 1, the dose of 16 mg/kg of MnCl2 did not induce behavioral alterations that could interfere with interpreting the imaging data. In experiment 2, we found a clear preference for the female in both the SIM and PP tests. We found a higher signal intensity in the olfactory bulb (OB) in week 1 of the SIM test compared to the control group. We also found increased signal intensity in the socio-sexual behavior and mesolimbic reward circuits in the SIM test in week 1. In the PP test, we found a higher signal intensity in the ventral tegmental area (VTA) in week 10 compared to the control group. In the same test, we found increased signal intensity in the socio-sexual and mesolimbic reward circuits in week 5 compared to the control group. Cohen's d analysis of the whole brain revealed that as the subjects gained sexual experience we observed a higher brain activation in the OB in the SIM group. The PP group showed higher brain activation in the cortex and subcortical structures as they acquired sexual experience.DiscussionAs the subjects gain sexual experience, more structures of the reward and socio-sexual circuits are recruited, resulting in different, and large brain activations.

Sexual motivation is an abstract concept referring to the mechanisms determining the responsivity to sexually relevant stimuli. This responsivity determines the likelihood of producing a sexual response and the intensity of that response. Both responsivity to stimuli and the likelihood of making a response as well as the intensity of response are characteristics of an individual. Therefore, we need to assume that the concept of sexual motivation materializes in physiological mechanisms within the individual. The aim of the present communication is to analyze the requisites for the endeavor to materialize sexual motivation. The first requisite is to provide an operational definition, making the concept quantifiable. We show that parameters of copulatory behavior are inappropriate. We argue that the intensity of sexual approach behaviors provides the best estimate of sexual motivation in non-human animals, whereas the magnitude of genital responses is an exquisite indicator of human sexual motivation. Having assured how to quantify sexual motivation, we can then proceed to the search for physiological or neurobiological underpinnings. In fact, sexual motivation only manifests itself in animals exposed to appropriate amounts of gonadal hormones. In female rats, the estrogen receptor α in the ventrolateral part of the ventromedial nucleus of the hypothalamus is necessary for the expression of sexual approach behaviors. In male rats, androgen receptors within the medial preoptic area are crucial. Thus, in rats sexual motivation can be localized to specific brain structures, and even to specific cells within these structures. In humans, it is not even known if sexual motivation is materialized in the brain or in peripheral structures. Substantial efforts have been made to determine the relationship between the activity of neurotransmitters and the intensity of sexual motivation, particularly in rodents. The results of this effort have been meager. Likewise, efforts of finding drugs to stimulate sexual motivation, particularly in women complaining of low sexual desire, have produced dismal results. In sum, it appears that the abstract concept of sexual motivation can be reliably quantified, and the neurobiological bases can be described in non-human animals. In humans, objective quantification is feasible, but the neurobiological substrate remains enigmatic.

Couples experience greater satisfaction and desire when they are motivated to meet each other's sexual needs (sexual communal strength); however, doing so at the expense of one's own sexual needs (unmitigated sexual communion) can detract from satisfaction and desire. Self-determination theory suggests engaging in sex for pleasure and value (autonomous reasons) versus out of pressure and obligation (controlled reasons) may account for these differences. Across two dyadic studies, one cross-sectional (N = 103 couples) and one longitudinal (N = 147 couples), people higher in sexual communal strength had sex for more autonomous and less controlled reasons, and in turn, reported greater satisfaction and desire, overall, in daily life, and over time. In contrast, people higher in unmitigated sexual communion endorsed more controlled reasons for engaging in sex, and in turn reported lower satisfaction. Partners of people higher in sexual communal strength reported less controlled reasons for engaging in sex, and in turn, both partners felt more satisfied, whereas partners of people high in unmitigated sexual communion endorsed more controlled reasons and reported lower satisfaction. This research furthers our understanding of when and why being motivated to be responsive to a partner's sexual needs enhances or detracts from sexual and relationship quality. [ABSTRACT FROM AUTHOR]

Group sex (i.e., sex involving four or more simultaneous partners) is a prevalent but stigmatized sexual behaviour. People assume that group sex centers around self-focused pleasure/physical gratification and that accordingly, this must be the primary motivation people have for engaging in group sex. Yet emerging research on group sex, as well as broader sexuality research and theory, suggests that group sex motivations are multifaceted and, for many, tied to community and belonging. In the present study, we focus on people's reasons for engaging in group sex. We recruited twenty participants of diverse genders, sexual identities/orientations, ages (≥18 years), abilities, and group sex communities for individual interviews in southwestern British Columbia. We found that participants had engaged in group sex for a plurality of reasons, including their desire for novelty, sexual exploration, spirituality, and their upbringing. Importantly, many were motivated to have group sex by their belonging and acceptance in communities of like-minded individuals that embraced sex-positive principles and values. Pleasure was also an important motivator and was described in multifaceted ways and was intertwined with sexual empowerment, emotional vulnerability, and feelings of connection and intimacy. These findings shed light on an understudied aspect of group sex – that is, why people have it – and challenge the assumption that group sex is entirely motivated by self-focused desire for physical pleasure/gratification. Instead, they highlight how group sex motivation can be multifaceted and community focused. [ABSTRACT FROM AUTHOR]

Introduction: Asprosin is an adipokine released from white adipose tissue during fasting and acts through the olfactory receptor. It is known that adipokines play roles in reproductive physiology in mammals. However, there are very few studies conducted on role of asprosin in reproductive functions. There are no studies on its relationship with sexual motivation. It was shown in the literature that administration of asprosin to male mice improves olfaction. It is also known that there is a strong correlation between smell and sexual desire. In view of this, it was hypothesized that chronic administration of asprosin would improve olfactory performance and increase sexual incentive motivation in female rats for male partners. Methods: This hypothesis was tested by applying the hidden cookie test, sexual incentive test, active research test, and sexual behavior test. The changes in serum hormone levels in female rats that chronically received asprosin were also measured and compared. Results: Chronic asprosin exposure increased olfactory performance, male preference ratio, male investigation preference ratio, activity index, and anogenital investigation behavior. Also, serum oxytocin and estradiol levels increased following chronic administration of asprosin in female rats. Conclusion: These data suggest that chronic administration of asprosin can result in increased sexual incentive motivation for opposite sex in female rats over increased olfactory performance and changes in reproductive hormones. [ABSTRACT FROM AUTHOR]

Highlights Leuprolide acetate (50 µg/kg, postnatal day 25–50) suppresses pubertal development in female and male rats. Estrous cyclicity is suppressed during treatment in female rats. Development of male copulatory behavior and sexual motivation is significantly delayed but reaches control levels within a month of treatment termination. Female sexual motivation and fertility are unaffected by leuprolide once treatment ends.

The present study explored sex differences in the predictors of relationship satisfaction (dyadic coping, love, sexual motivation, having children). A total of 465 Hungarian participants (319 women and 146 men) with a mean age of 33.6 years completed an online test battery comprising four self-report measures. The results revealed that women’s relationship satisfaction had more significant predictors than men’s, and half of the common predictors showed significant sex differences. Men’s satisfaction was positively predicted by the Intimacy and Passion components of love, while it was negatively predicted by Negative Dyadic Coping and by having at least one child. Besides Intimacy and Passion, two common predictors across sexes, women’s satisfaction was also positively predicted by the Commitment component of love, and also by successful coping with dyadic stress. By contrast, negative predictors were having sex as a means of coping with emotional problems (Sex as Coping), the individual aspect of dyadic coping (One’s Own Dyadic Coping), and Negative Dyadic coping. The findings are discussed in both bio-psychological and social constructionist approaches.

Maternal behavior in mammals encompasses a complex repertoire of activities that ensure the survival of the offspring and shape their neural and behavioral development. The laboratory rat has been employed as a classic model for investigating maternal behavior, and recently with the use of advanced techniques, the knowledge of its neural basis has been expanded significantly. However, the standard laboratory testing conditions in which rats take care of a single litter impose constraints on the study of maternal flexibility. Interestingly, the reproductive characteristics of this species, including the existence of a fertile postpartum estrus, allow us to study maternal behavior in more complex and ethologically relevant contexts, even in laboratory settings. Here we review how maternal and sexual motivations interact during the postpartum estrus, shaping the behavioral response of females according to the presence of the pups and males. Next, we describe how impregnation during the postpartum estrus creates a new reproductive context in which mothers simultaneously care for two successive litters, adapting their responses to different behavioral and physiological demands of pups. These findings illustrate the behavioral adaptability of maternal rats to pups’ needs and the presence of other reinforcers, as well as its dependence on the context. In our view, future perspectives in the field, by incorporating the use of cutting-edge techniques, should analyze maternal flexibility and its neural substrates in models that incorporate complex and challenging contexts. This approach would allow a more comprehensive understanding of brain circuits involved in the adaptive and flexible nature of parenting. [ABSTRACT FROM AUTHOR]

In this study, the motivations of 80 sex workers who provide camming services (76 females and 4 non-binary/trans/gender fluid individuals; aged from 20 to 49 years, M = 30.68, SD = 6.43; 56.2% married or in a committed relationship, 18.8% in a non-committed relationship and 25% - single) were compared in terms of engaging in sexual activity with their real-life partners versus their virtual partners (predominantly kink-oriented clients). Presented with 16 reasons to engage in sexual activity, the respondents rated the frequency to engage in sex for each of these reasons with their real-life and virtual partners. Results showed that there were five reasons in which there were differences in motivation to engage in sex with real-life versus virtual partners and 11 reasons showed no differences. Specifically, respondents reported engaging in sex more often with their virtual partners to get resources and to experience a specific type of sex (kink), while they reported engaging in sex more often with their real-life partners to experience physical pleasure, motivated by physical desirability of a partner and to express love and commitment. However, for all other reasons that motivate people to engage in sex, including stress reduction, experience seeking, self-esteem boost, social status, revenge, utilitarian reasons, emotional expression, duty or pressure, thrill of the forbidden, mate guarding, and desire to have sex with a person of other gender, respondents engaged in sex equally frequently with their real-life and virtual partners (clients) and there were no statistical differences. This study adds to the existing research on sex work by providing insights into the motivations of sex workers to engage in sex with different partners and demonstrates that apart from common sense differences the reasons to engage in sex with clients and real-life partners are vastly similar. [ABSTRACT FROM AUTHOR]

We documented evidence of idiosyncratic but repeated twig-assisted genital stimulation by Balinese long-tailed macaques (Macaca fascicularis), living in Ubud, Indonesia. This population is known to customarily engage in genital stone-tapping/-rubbing, a behaviour expressed by males and females of different age classes as part of a broader cultural repertoire of stone-directed and overall playful actions known as stone handling. However, genital stimulation using other objects has never been reported in this population and species. We observed repeated and extensive twig-assisted genital stimulation in one adult female and one adult male. We also recorded three instances of twig-assisted genital stimulation in three additional individuals. Our results indicate that this behaviour is not accidental and may be sexually motivated; that is, it may be another form of tool-assisted masturbation in this primate population. This report provides a valuable addition to the increasing literature on tool-assisted behavioural innovations pertaining to self-care and possibly pleasure. [ABSTRACT FROM AUTHOR]

The endocannabinoid system (ECS) plays a key neuromodulatory role in the brain. Main features of endocannabinoids (eCBs) are that they are produced on demand, in response to enhanced neuronal activity, act as retrograde messengers, and participate in the induction of brain plasticity processes. Sexual activity is a motivated behavior and therefore, the mesolimbic dopaminergic system (MSL) plays a central role in the control of its appetitive component (drive to engage in copulation). In turn, copulation activates mesolimbic dopamine neurons and repeated copulation produces the continuous activation of the MSL system. Sustained sexual activity leads to the achievement of sexual satiety, which main outcome is the transient transformation of sexually active male rats into sexually inhibited animals. Thus, 24 h after copulation to satiety, the sexually satiated males exhibit a decreased sexual motivation and do not respond to the presence of a sexually receptive female with sexual activity. Interestingly, blockade of cannabinoid receptor 1 (CB1R) during the copulation to satiety process, interferes with both the appearance of the long-lasting sexual inhibition and the decrease in sexual motivation in the sexually satiated males. This effect is reproduced when blocking CB1R at the ventral tegmental area evidencing the involvement of MSL eCBs in the induction of this sexual inhibitory state. Here we review the available evidence regarding the effects of cannabinoids, including exogenously administered eCBs, on male rodent sexual behavior of both sexually competent animals and rat sub populations spontaneously showing copulatory deficits, considered useful to model some human male sexual dysfunctions. We also include the effects of cannabis preparations on human male sexual activity. Finally, we review the role played by the ECS in the control of male sexual behavior expression with the aid of the sexual satiety phenomenon. Sexual satiety appears as a suitable model for the study of the relationship between eCB signaling, MSL synaptic plasticity and the modulation of male sexual motivation under physiological conditions that might be useful for the understanding of MSL functioning, eCB-mediated plasticity and their relationship with motivational processes. [ABSTRACT FROM AUTHOR]

Purpose: Sexual motives are major determinants of sexual behaviour. It has been known that sexual motives may vary according to circumstances. Multiple sclerosis (MS) is a chronic disease causing a broad range of symptoms and disabilities, that often interfere with sexual activities. We aimed to investigate the sexual motives in persons with MS.Patients and Methods: Cross-sectional study in 157 persons with MS and 157 controls matched for age, gender, relationship, duration of relationship and educational status via propensity score matching. The Reasons for Having Sex (YSEX) questionnaire assessed the proportion with which a person had engaged in sexual intercourse for each of 140 distinct motives to have sex. Estimated mean differences in scores for four primary factors (Physical, Goal attainment, Emotional, Insecurity) and 13 sub-factors, and sexual satisfaction and importance of sex were calculated as Average Treatment Effect of the Treated using 99% confidence intervals.Results: Persons with MS reported a lower proportion of engaging in sex compared with the controls for the factors Physical (− 0.29), Emotional (− 0.23) and Insecurity (− 0.10); and for the physical sub-factors Pleasure (− 0.48), Experience seeking (− 0.32), Stress reduction (− 0.24), and Physical desirability (− 0.16), the emotional sub-factors Love and commitment (− 0.27) and Expression (− 0.17), and the insecurity sub-factor Self-esteem boost (− 0.23). In the control group seven of the top 10 sexual motives were physical versus five in the MS group. The importance of sex was lower in the MS group (− 0.68).Conclusion: Findings of this controlled cross-sectional study suggest a reduction in the number of sexual motives in persons with MS, especially of physical motives related to pleasure and experience seeking. Health care professionals may consider assessing sexual motivation when dealing with persons with MS who suffer from decreased sexual desire or another sexual dysfunction. [ABSTRACT FROM AUTHOR]

In this study, the motivations of 80 sex workers who provide camming services (76 females and 4 non-binary/trans/gender fluid individuals; aged from 20 to 49 years, M = 30.68, SD = 6.43; 56.2% married or in a committed relationship, 18.8% in a non-committed relationship and 25% - single) were compared in terms of engaging in sexual activity with their real-life partners versus their virtual partners (predominantly kink-oriented clients). Presented with 16 reasons to engage in sexual activity, the respondents rated the frequency to engage in sex for each of these reasons with their real-life and virtual partners. Results showed that there were five reasons in which there were differences in motivation to engage in sex with real-life versus virtual partners and 11 reasons showed no differences. Specifically, respondents reported engaging in sex more often with their virtual partners to get resources and to experience a specific type of sex (kink), while they reported engaging in sex more often with their real-life partners to experience physical pleasure, motivated by physical desirability of a partner and to express love and commitment. However, for all other reasons that motivate people to engage in sex, including stress reduction, experience seeking, self-esteem boost, social status, revenge, utilitarian reasons, emotional expression, duty or pressure, thrill of the forbidden, mate guarding, and desire to have sex with a person of other gender, respondents engaged in sex equally frequently with their real-life and virtual partners (clients) and there were no statistical differences. This study adds to the existing research on sex work by providing insights into the motivations of sex workers to engage in sex with different partners and demonstrates that apart from common sense differences the reasons to engage in sex with clients and real-life partners are vastly similar.

Maternal behavior in mammals encompasses a complex repertoire of activities that ensure the survival of the offspring and shape their neural and behavioral development. The laboratory rat has been employed as a classic model for investigating maternal behavior, and recently with the use of advanced techniques, the knowledge of its neural basis has been expanded significantly. However, the standard laboratory testing conditions in which rats take care of a single litter impose constraints on the study of maternal flexibility. Interestingly, the reproductive characteristics of this species, including the existence of a fertile postpartum estrus, allow us to study maternal behavior in more complex and ethologically relevant contexts, even in laboratory settings. Here we review how maternal and sexual motivations interact during the postpartum estrus, shaping the behavioral response of females according to the presence of the pups and males. Next, we describe how impregnation during the postpartum estrus creates a new reproductive context in which mothers simultaneously care for two successive litters, adapting their responses to different behavioral and physiological demands of pups. These findings illustrate the behavioral adaptability of maternal rats to pups’ needs and the presence of other reinforcers, as well as its dependence on the context. In our view, future perspectives in the field, by incorporating the use of cutting-edge techniques, should analyze maternal flexibility and its neural substrates in models that incorporate complex and challenging contexts. This approach would allow a more comprehensive understanding of brain circuits involved in the adaptive and flexible nature of parenting.

The endocannabinoid system (ECS) plays a key neuromodulatory role in the brain. Main features of endocannabinoids (eCBs) are that they are produced on demand, in response to enhanced neuronal activity, act as retrograde messengers, and participate in the induction of brain plasticity processes. Sexual activity is a motivated behavior and therefore, the mesolimbic dopaminergic system (MSL) plays a central role in the control of its appetitive component (drive to engage in copulation). In turn, copulation activates mesolimbic dopamine neurons and repeated copulation produces the continuous activation of the MSL system. Sustained sexual activity leads to the achievement of sexual satiety, which main outcome is the transient transformation of sexually active male rats into sexually inhibited animals. Thus, 24 h after copulation to satiety, the sexually satiated males exhibit a decreased sexual motivation and do not respond to the presence of a sexually receptive female with sexual activity. Interestingly, blockade of cannabinoid receptor 1 (CB1R) during the copulation to satiety process, interferes with both the appearance of the long-lasting sexual inhibition and the decrease in sexual motivation in the sexually satiated males. This effect is reproduced when blocking CB1R at the ventral tegmental area evidencing the involvement of MSL eCBs in the induction of this sexual inhibitory state. Here we review the available evidence regarding the effects of cannabinoids, including exogenously administered eCBs, on male rodent sexual behavior of both sexually competent animals and rat sub populations spontaneously showing copulatory deficits, considered useful to model some human male sexual dysfunctions. We also include the effects of cannabis preparations on human male sexual activity. Finally, we review the role played by the ECS in the control of male sexual behavior expression with the aid of the sexual satiety phenomenon. Sexual satiety appears as a suitable model for the study of the relationship between eCB signaling, MSL synaptic plasticity and the modulation of male sexual motivation under physiological conditions that might be useful for the understanding of MSL functioning, eCB-mediated plasticity and their relationship with motivational processes.

Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)- "endocannabinoidome", consists of the endogenous ligands, eCBs, their canonical and non-canonical receptor subtypes, and their synthesizing and metabolizing enzymes. This system modulates a wide range of body functions and acts as a retrograde signaling system within the central nervous system (CNS) by inhibition of classical transmitters, and plays a vital modulatory function on dopamine, a major neurotransmitter in the CNS. Dopamine is involved in different behavioral processes and contributes to different brain disorders--including Parkinson's disease, schizophrenia, and drug addiction. After synthesis in the neuronal cytosol, dopamine is packaged into synaptic vesicles until released by extracellular signals. Calcium dependent neuronal activation results in the vesicular release of dopamine and interacts with different neurotransmitter systems. The ECS, among others, is involved in the regulation of dopamine release and the interaction occurs either through direct or indirect mechanisms. The cross-talk between the ECS and the dopaminergic system has important influence in various dopamine-related neurobiological and pathologic conditions and investigating this interaction might help identify therapeutic targets and options in disorders of the CNS associated with dopamine dysregulation. [ABSTRACT FROM AUTHOR]

Background and Objectives Within relationships, sexual motives and stress are independent determinants of psychological health, with notable gendered patterns. However, previous research largely focuses on young adults and different-sex couples. Both sexual motives and levels of stress may be uniquely important to psychological health in midlife, and in potentially different ways for same-sex and different-sex couples. This study examined how the associations between sexual motives, stress, and depressive symptoms differ for midlife men and women in same-sex and different-sex marriages. Research Design and Methods Using dyadic data from same-sex and different-sex midlife married couples (N = 830 individuals; 415 couples), we examined the associations of intrinsic (e.g. sex for enjoyment and pleasure) and extrinsic (e.g. sex to please one's spouse) motives for having sex with depressive symptoms and tested whether these associations differed by levels of stress for same-sex and different-sex spouses. Results Intrinsic sexual motives were associated with fewer depressive symptoms only for same-sex married couples under high stress. Extrinsic sexual motives were related to greater depressive symptoms for women in low-stress conditions and men in high-stress conditions, and this did not differ for same-sex compared to different-sex marriages. Discussion and Implications Results show that the interplay between sexual motives and stress varies for men and women in same-sex and different-sex marriages. These findings underscore the importance of considering both gender and sexuality in studying sexual motives in midlife and suggest sexual motives as a useful treatment focus for protecting the psychological health of midlife married couples. [ABSTRACT FROM AUTHOR]

The sexual behavior of the female rat has been extensively studied and used as a model for human female sexuality. The development of models that focus on sexual interaction from the female’s perspective has demonstrated the complexity of this behavior, in which motivational and affective aspects have great relevance. This review describes, from a historical perspective, some of the studies that have shed light on this complexity and presents the potential of two periods in the female’s life to expand our understanding of sexual behavior: adolescence and postpartum estrus. Cycling adolescent female rats can express sexual behavior even though some of the underlying circuitry is still developing. Therefore, this is an ideal time for studying the ontogeny of sexual behavior, the interaction of sexual and social motivations, and the neuroendocrine changes that lead to adult behavior. Female rats also show a fertile estrus a few hours after parturition. During this period, rats are simultaneously sexually and maternally motivated, making postpartum estrus an excellent model for exploring the interaction of these two social motivations. What we know so far about female sexual behavior in these unique periods of life reaffirms its richness and shows that much remains to be known.

Endocannabinoids (eCBs) and the expanded endocannabinoid system (ECS)-“endocannabinoidome”, consists of the endogenous ligands, eCBs, their canonical and non-canonical receptor subtypes, and their synthesizing and metabolizing enzymes. This system modulates a wide range of body functions and acts as a retrograde signaling system within the central nervous system (CNS) by inhibition of classical transmitters, and plays a vital modulatory function on dopamine, a major neurotransmitter in the CNS. Dopamine is involved in different behavioral processes and contributes to different brain disorders—including Parkinson’s disease, schizophrenia, and drug addiction. After synthesis in the neuronal cytosol, dopamine is packaged into synaptic vesicles until released by extracellular signals. Calcium dependent neuronal activation results in the vesicular release of dopamine and interacts with different neurotransmitter systems. The ECS, among others, is involved in the regulation of dopamine release and the interaction occurs either through direct or indirect mechanisms. The cross-talk between the ECS and the dopaminergic system has important influence in various dopamine-related neurobiological and pathologic conditions and investigating this interaction might help identify therapeutic targets and options in disorders of the CNS associated with dopamine dysregulation.

Background: GnRH agonists have been used to halt the development of puberty in children with precocious puberty since the 1980s. Recently, drugs like Lupron Depot® (leuprolide acetate), have been used to suppress pubertal progression in adolescents who are questioning their gender identity. However, few preclinical studies have been conducted to investigate potential effects of using GnRH agonists in this context. Methods: The present study tested the effects of daily leuprolide treatment (50 µg/kg, postnatal day (PD) 25–50) on pubertal onset in female (i.e., vaginal opening) and male (i.e., preputial separation) Long-Evans rats. The first estrous cycle immediately after vaginal opening was also measured. Sexual behavior and sexual motivation were tested using the partner-preference paradigm. Female rats were tested during the first behavioral estrus after treatment ended (between PD 51–64). Male rats were tested weekly for four consecutive weeks starting three days after treatment ended (PD 53). Results: Consistent with previous findings, leuprolide significantly delayed pubertal onset in both female and male rats. In addition, the first estrous cycle during the treatment period was disrupted by leuprolide, as indicated by a failure to cycle into estrus after vaginal opening until treatment ended. However, leuprolide affected neither sexual motivation nor fertility when female rats were tested within 14 days of leuprolide treatment ending. In contrast, the development of copulatory behavior and sexual motivation was significantly delayed by leuprolide in male rats; however, mature reproductive behavior was observed by the fourth week post-treatment. Conclusions: Taken together with previous findings, the present results indicate that male rats may be more sensitive to periadolescent leuprolide administration, taking longer to overcome the effects of leuprolide than female rats. Nevertheless, not long after leuprolide treatment is discontinued, sex-typical reproductive physiology and behavior emerge fully in female and male rats, indicating that the drug's effects are not permanent. If translatable to humans, leuprolide may be a reversible option to give adolescents more time to consider their gender identity with minimal long-term effects on sexual development. Highlights: Leuprolide acetate (50 µg/kg, postnatal day 25–50) suppresses pubertal development in female and male rats. Estrous cyclicity is suppressed during treatment in female rats. Development of male copulatory behavior and sexual motivation is significantly delayed but reaches control levels within a month of treatment termination. Female sexual motivation and fertility are unaffected by leuprolide once treatment ends. [ABSTRACT FROM AUTHOR]

The present study explored sex differences in the predictors of relationship satisfaction (dyadic coping, love, sexual motivation, having children). A total of 465 Hungarian participants (319 women and 146 men) with a mean age of 33.6 years completed an online test battery comprising four self-report measures. The results revealed that women's relationship satisfaction had more significant predictors than men's, and half of the common predictors showed significant sex differences. Men's satisfaction was positively predicted by the Intimacy and Passion components of love, while it was negatively predicted by Negative Dyadic Coping and by having at least one child. Besides Intimacy and Passion, two common predictors across sexes, women's satisfaction was also positively predicted by the Commitment component of love, and also by successful coping with dyadic stress. By contrast, negative predictors were having sex as a means of coping with emotional problems (Sex as Coping), the individual aspect of dyadic coping (One's Own Dyadic Coping), and Negative Dyadic coping. The findings are discussed in both bio-psychological and social constructionist approaches. [ABSTRACT FROM AUTHOR]

Objective: Previous research has found that college students experience both positive and negative outcomes after a hookup. The present study examined the role that hookup motives and sex play in determining the overall positivity and negativity of the experience. Participants: College students (N = 156) completed an online survey about their most recent hookup. Method: The survey assessed hookup motivations and outcomes. Results: Lower coping motives and higher social-sexual, relationship-seeking, and enhancement motives predicted more positive outcomes. Higher coping motives and lower social-sexual, conformity, and enhancement motives predicted more negative outcomes. For men, positive outcomes were correlated with weaker enhancement motives, while negative outcomes were correlated with more enhancement motives. For women, higher levels of positive outcomes were positively correlated with enhancement, social-sexual, and relationship-seeking motives, while negative outcomes were negatively correlated with social-sexual, enhancement, and coping motives. Conclusions: The results of this study have implications for risk prevention and future research. [ABSTRACT FROM AUTHOR]

The present study developed a brief version of the Hungarian Why Sex? questionnaire (Meskó et al., 2022). The study was in part based on previously reported data obtained from several samples (N = 6193; 1976 men, 4217 women). Using Mokken Scaling Procedure, Item Response Model and redundancy analysis indicated that retaining three summary scales comprising five items each was the optimal solution for the brief version. The validity of the brief scale was tested with the Sexual System Functioning Scale (SSFS), the Experiences in Close Relationships Scale-Short Form (ECR-S) and, the Hungarian version of the Attachment Style Questionnaire (ASQ-H; n = 297, 127 men, 170 women). In addition, correlations between the long and brief versions of YSEX? with sociosexual orientation (SOI-R) and the five-factor personality construct (BFI-S) were compared (n = 1024, 578 women, 446 men). The results suggest that the three summary scales of the Hungarian 15-item Form of the Why Sex Questionnaire (YSEX?-15H) provide reliable and valid measures of the previously affirmed three broad sexual motives (Personal Goal Attainment, Relational Reasons, Sex as Coping). The Relational Reasons summary scale was associated with secure emotional and sexual attachment. The Personal Goal Attainment and Sex as Coping summary scales showed coherent patterns of associations with the emotional and sexual aspects of secondary attachment strategies (over- and under-functioning). The YSEX?-15H offers both researchers and practitioners a concise and useful instrument for the assessment of sexual motivation. [ABSTRACT FROM AUTHOR]

We investigated the effect of fluctuations in negative and positive affect on momentary sexual motivation in a sample of women and men in a steady relationship (n = 133). Sexual motivation was regarded as the aggregate of sexual desire, subjective sexual arousal and openness to sexual contact. Experience sampling methodology was used to collect up to 70 measurements per participant over a period of seven consecutive days of sexual motivation, and negative and positive affect. Using multilevel analysis, we investigated cross-level interactions between affect and trait measures as specified in the dual control model (DCM). This model postulates sexually excitatory and inhibitory mechanisms as relatively independent systems that together can explain individual differences in sexual motivation and behavior. Results implicated that any intensification of feelings, positive or negative, was associated with a momentary increase in sexual motivation for participants more prone to sexual excitation. In the lagged analysis, higher preceding negative affect, measured 1-2 h earlier, forecasted an increase in current sexual motivation for participants more prone to sexual excitation. The lagged analysis included the autoregressive effect or inertia of sexual motivation. Inertia reflects the extent to which sexual motivation lingers and persists at similar levels. Our findings showed that sexual motivation levels persisted less in individuals with higher sexual inhibition proneness due to threat of performance failure. This study demonstrated how experience sampling methodology can be used to extend research on associations between mood and sexual motivation and implicates that DCM factors moderate these associations. [ABSTRACT FROM AUTHOR]

Rationale: Exposure of male rats to an inaccessible receptive female and copulation increases dopamine (DA) levels in the nucleus accumbens (NAcc). Males copulating to satiety become sexually inhibited and most of them do not display sexual activity when presented with a sexually receptive female 24 h later. This inhibitory state can be pharmacologically reversed. There are no studies exploring NAcc DA levels during this sexual inhibitory state. Objectives: To characterize changes in NAcc DA and its metabolites' levels during sexual satiety development, during the well-established sexual inhibitory state 24 h later, and during its pharmacological reversal. Methods: Changes in NAcc DA and its metabolites were measured in sexually experienced male rats, using in vivo microdialysis, during copulation to satiety, when presented to a new sexually receptive female 24 h later, and during the pharmacological reversal of the sexual inhibition by anandamide. Results: NAcc DA levels remained increased during copulation to satiety. DA basal levels were significantly reduced 24 h after copulation to satiety, as compared to the initial basal levels. Presenting a receptive female behind a barrier 24 h after satiety did not induce the typical NAcc DA elevation in the sexually satiated males but there was a decrease that persisted when they got access to the female, with which they did not copulate. Anandamide injection slightly increased NAcc DA levels coinciding with sexual satiety reversal. Conclusions: Reduced NAcc DA concentrations coincide with the inhibition of an instinctive, natural rewarding behavior suggesting that there might be a DA concentration threshold needed to be responsive to a rewarding stimulus. [ABSTRACT FROM AUTHOR]

This study compared motivations of individuals in non-monogamous relationships to engage in sex with their different partners (n = 596, out of which 103 non-consensual non-monogamous, 135 polyamorous, 204 swinging, 154 in open relationships; women--38.8%, men--59.7%, other gender--1.5%; age range: from 18 to 65+ years; 86% of respondents between 25 and 54 years old; majority of the respondents are in a long-term relationship). The research aim was to identify whether there are differences in reasons to engage in sex with respondents' primary versus secondary partners. Presented with 17 reasons to engage in sexual activity, the respondents rated the frequency with which they engage in sex for each reason with their different partners. Questions for 14 reasons to engage in sex were created based on the YSEX? questionnaire and three questions were created specifically for non-monogamous population. The three new questions addressed the desire for a specific type of sex (such as kink, fetish, etc.), desire to have sex with a partner of another gender than one's primary partner, and desire to experience the thrill of the forbidden. The results indicated that there are significant differences in motivation to engage in sex with one's primary versus secondary partner for most of the reasons. Additionally, this study investigated whether there are differences in motivation to engage in sex with different partners depending on the relationship arrangement. The data analysis shows that there are differences in reasons to engage in sex with one's different partners between non-consensually and consensually non-monogamous groups. This research compliments existing body of research with new reasons to engage in sex, it demonstrates that non-monogamous people engage in sex with their different partners for different reasons and reveals that these may vary depending on the type of the relationship arrangement. [ABSTRACT FROM AUTHOR]

Few spheres in life are as universally relevant for (almost) all individuals past puberty as sexuality. One important aspect of sexuality concerns individuals' sex drive—their dispositional sexual motivation. A vigorous scientific (and popular) debate revolves around the question of whether or not there is a gender difference in sex drive. Several theories predict a higher sex drive in men compared to women, with some theories attributing this difference to biased responding rather than true differences. Currently, there is little consensus on how to conceptualize sex drive, nor does a quantitative summary of the literature exist. In this article, we present a theory-driven conceptualization of sex drive as the density distribution of state sex drive, where state sex drive is defined as momentary sexual motivation that manifests in sexual cognition, affect, and behavior. We conduct a comprehensive meta-analysis of gender differences in sex drive based on 211 studies, 856 effect sizes, and 621,463 persons. The meta-analysis revealed a stronger sex drive in men compared to women, with a medium-to-large effect size, g = 0.69, 95% CI [0.58, 0.81]. Men more often think and fantasize about sex, more often experience sexual affect like desire, and more often engage in masturbation than women. Adjustment for biased responding reduced the gender difference (g = 0.54). Moderation analyses suggest that the effect is robust and largely invariant to contextual factors. There was no evidence of publication bias. The discussion focuses on validity considerations, limitations, and implications for psychological theory and people's everyday lives. Public Significance Statement: This article explains sex drive from a scientific, psychological perspective—operationalized as sexual thoughts, desire, and masturbation frequency—and provides support using a meta-analytic review that men have a stronger sex drive than women. Some but not all of these gender differences may be caused by men overreporting and/or women underreporting their sex drive. These findings advance our understanding of sexual dynamics in interpersonal relationships and society at large. [ABSTRACT FROM AUTHOR]

This study compared motivations of individuals in non-monogamous relationships to engage in sex with their different partners (n = 596, out of which 103 non-consensual non-monogamous, 135 polyamorous, 204 swinging, 154 in open relationships; women—38.8%, men—59.7%, other gender—1.5%; age range: from 18 to 65+ years; 86% of respondents between 25 and 54 years old; majority of the respondents are in a long-term relationship). The research aim was to identify whether there are differences in reasons to engage in sex with respondents’ primary versus secondary partners. Presented with 17 reasons to engage in sexual activity, the respondents rated the frequency with which they engage in sex for each reason with their different partners. Questions for 14 reasons to engage in sex were created based on the YSEX? questionnaire and three questions were created specifically for non-monogamous population. The three new questions addressed the desire for a specific type of sex (such as kink, fetish, etc.), desire to have sex with a partner of another gender than one’s primary partner, and desire to experience the thrill of the forbidden. The results indicated that there are significant differences in motivation to engage in sex with one’s primary versus secondary partner for most of the reasons. Additionally, this study investigated whether there are differences in motivation to engage in sex with different partners depending on the relationship arrangement. The data analysis shows that there are differences in reasons to engage in sex with one’s different partners between non-consensually and consensually non-monogamous groups. This research compliments existing body of research with new reasons to engage in sex, it demonstrates that non-monogamous people engage in sex with their different partners for different reasons and reveals that these may vary depending on the type of the relationship arrangement.

The aim of this article is to draw attention to an issue that has a long history: the problem of hate crimes in the United States of America. There is no doubt that hate crimes are the type of crime that attack the very principle of individuality that is an entitlement under the equal protection of the law (in the U.S.). Bearing the foregoing in mind the above, and that the number of such crime has increased at an alarming rate, this article describes and discusses types of hate crimes such as: Racist and Religious Hate Crimes, Sexual Orientation-Based Hate Crimes and Disability Hate Crimes as an extended projection of the analysis, several solutions have been proposed to mitigate tensions and combat the prevalence and severity of hate crime in all its forms.

Early and recent studies show that dopamine through its neuronal systems and receptor subtypes plays different roles in the control of male sexual behavior. These studies show that (i) the mesolimbic/mesocortical dopaminergic system plays a key role in the preparatory phase of sexual behavior, e.g., in sexual arousal, motivation and reward, whereas the nigrostriatal system controls the sensory-motor coordination necessary for copulation, (ii) the incertohypothalamic system is involved in the consummatory aspects of sexual behavior (penile erection and copulation), but evidence for its role in sexual motivation is also available, (iii) the pro-sexual effects of dopamine occur in concert with neural systems interconnecting the hypothalamus and preoptic area with the spinal cord, ventral tegmental area and other limbic brain areas and (iv) D2 and D4 receptors play a major role in the pro-sexual effects of dopamine. Despite some controversy, increases or decreases, respectively, of brain dopamine activity induced by drugs or that occur physiologically, usually improves or worsens, respectively, sexual activity. These findings suggest that an altered central dopaminergic tone plays a role in mental pathologies characterized by aberrant sexual behavior, and that pro-erectile D4 receptor agonists may be considered a new strategy for the treatment of erectile dysfunction in men. [ABSTRACT FROM AUTHOR]

The sexual behavior of the female rat has been extensively studied and used as a model for human female sexuality. The development of models that focus on sexual interaction from the female's perspective has demonstrated the complexity of this behavior, in which motivational and affective aspects have great relevance. This review describes, from a historical perspective, some of the studies that have shed light on this complexity and presents the potential of two periods in the female's life to expand our understanding of sexual behavior: adolescence and postpartum estrus. Cycling adolescent female rats can express sexual behavior even though some of the underlying circuitry is still developing. Therefore, this is an ideal time for studying the ontogeny of sexual behavior, the interaction of sexual and social motivations, and the neuroendocrine changes that lead to adult behavior. Female rats also show a fertile estrus a few hours after parturition. During this period, rats are simultaneously sexually and maternally motivated, making postpartum estrus an excellent model for exploring the interaction of these two social motivations. What we know so far about female sexual behavior in these unique periods of life reaffirms its richness and shows that much remains to be known. [ABSTRACT FROM AUTHOR]

There are ongoing debates about conflicting models on how to conceptualize compulsive sexual behavior. At the heart of these discussions is the question about the sexual motivations underlying compulsive sexual behavior, as different models assume different motivations. The aim of the present study was to understand sexual motivations underlying compulsive sexual behavior and their relation to the most prominent conceptualizations of compulsive sexual behavior (eg, compulsive sexual behavior disorder [CSBD], sex addiction). We used self-reported data from 2 large samples of Hungarian and German populations (N = 9814). The Sexual Motivation Scale (SexMS), a 24-item self-report measure based on self-determination theory, was used to assess a diverse set of sexual motivations. Compulsive sexual behavior was assessed with the 19-item Compulsive Sexual Behavior Disorder Scale (CSBD-19), that is based on the ICD-11 diagnostic guidelines of CSBD. We used structural equation modeling to examine the hypothesized associations between sexual motivations and compulsive sexual behavior and examined potential gender differences in these associations. Compulsive sexual behavior was assessed in relation to a set of sexual motivations. Amotivation had the strongest positive association with compulsive sexual behavior, but integrated, introjected, and intrinsic motivations were also positively related to it. Importantly, these associations did not differ for women and men, and between the 2 samples. Future research and treatment should also consider sexual motivations that are not listed among the ICD-11 guidelines for CSBD, including high levels of sexual interest, continuing the behavior despite having little satisfaction from it and coping with sex. Although we used large samples of general populations in 2 Western countries, this motivational background of compulsive sexual behavior awaits replication in a clinical sample of individuals experiencing CSBD. The identified sexual motivations underlying compulsive sexual behavior are relevant for assessing and treating patients as motivations may be integrated into psychotherapeutic interventions. Koós M, Fuss J, Klein V, et al. Sexual Motivations Underlying Compulsive Sexual Behavior in Women and Men From Germany and Hungary. J Sex Med 2022;19:170–181. [ABSTRACT FROM AUTHOR]

Background: One of the less explored effects of diabetes mellitus (DM) is female sexual dysfunction. Females of different species have been used as models., Aim: To analyze the information of animal models of DM and female sexual response (FSR)., Methods: The literature of FSR in models of DM was reviewed., Outcomes: Paradigm- and diabetes-dependent changes have been found in various aspects of the FSR., Results: Females in a type 1 DM (DM1) model show a decrease in the number of proestrus events, and ovariectomized females treated with sex hormones have been used. In these females, a reduction in lordosis has been reported; in proceptivity, the data are contradictory. These females present a decrease in sexual motivation that was restored after exogenous insulin. In the type 2 DM (DM2) model, females show regular estrous cycles, normal levels of lordosis behavior, and, depending on the paradigm, decreased proceptivity. These females display normal preference for sexually active males or their olfactory cues when having free physical contact; they lose this preference when tested in paradigms where physical interaction is precluded., Clinical Translation: Preclinical data showing the high deleterious effects of a DM1 model and the less drastic effects under a DM2 model are in accordance with clinical data revealing a much higher prevalence of sexual dysfunction in women with DM1 than DM2., Strengths and Limitations: The main strength is the analysis of the changes in various components of FSR in 2 models of DM. The main limitation is the difficulty in extrapolating the data on FSR from rats to women and that most studies focus on evaluating the impact of severe or chronic-moderate hyperglycemia/hyperinsulinemia on the sexual response, without considering other pathophysiologic alterations generated by DM., Conclusion: Females with severe hyperglycemia have a decrease in FSR, while those with moderate hyperglycemia show much less drastic effects., (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society of Sexual Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)