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9 results on '"sehi"'

6. Secondary electron hyperspectral imaging: nanostructure and chemical analysis for the LV-SEM.

Author

Nohl, James F.

Subjects
*SCANNING electron microscopes, *NANOSTRUCTURES, *CARBON, *SURFACE analysis, *SECONDARY electron emission
Abstract

Materials engineers have increasing control over nanoscale chemical composition and nanostructures. The latter can be easily analysed by the scanning electron microscope (SEM) yet nanoscale chemical analysis in the SEM poses challenges. Nevertheless, nanoscale chemical analysis capabilities have been developed in the LV-SEM by secondary electron hyperspectral imaging (SEHI). In this article, the insights that SEHI has provided into well characterised semiconductor, photovoltaic, polymer and hard carbon materials are reviewed. Instrument and experimental considerations for the obtainment of secondary electron hyper-spectra are discussed and recommendations for future analyses in the LV-SEM by SEHI are made. [ABSTRACT FROM AUTHOR]

Published
2020
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7. Expression of fatty acid synthase and inflammation severity evaluation in peripheral blood of patients with ACS and intervention effect of sEHi

Author

Wei Wang, Yue-Xi Wang, De-Chao Zhong, Dan Li, and Mao Chen

Subjects
Inflammation, lcsh:R, lcsh:Medicine, sEHi, ACS, Fatty acid synthase
Abstract

Objective: To analyze fatty acid synthase expression and inflammation degree evaluation in peripheral blood of patients with ACS and intervention effect of sEHi. Methods: Inclusion time of all research subjects was from January 2013 to February 2015, 132 cases of patients with acute coronary syndrome included 68 cases of patients with acute ST segment elevation myocardial infarction (STEMI) and 64 cases of patients with non-ST segment elevation acute coronary syndrome (NSTE-ACS), 78 cases of healthy subjects who received physical examination in our hospital were selected as healthy control group, fatty acid synthase expression and inflammation degree in peripheral blood of three groups were detected, and differences in levels of fatty acid synthase, inflammatory factors and blood lipid in patients with ACS before and after sEHi intervention were compared. Results: Serum FASN, CRP, IL-6, IL-12, IL-18 and IL-23 levels of STEMI group were higher than those of NSTE-ACS group and healthy control group; serum FASN level of patients with ACS after sEHi intervention was lower than that before intervention, and values of inflammatory factors CRP, IL-6, IL-12, IL- 18 and IL-23 were also dramatically lower than those before intervention; TC, TG and LDL-C levels of patients with ACS after sEHi intervention were lower than those before intervention, and HDL-C levels were higher than those before intervention. Conclusion: Fatty acid synthase expression and inflammation degree increase in peripheral blood of patients with ACS, levels of fatty acid synthase, inflammation and blood lipid are optimized after sEHi intervention, and it is an effective way to treat ACS.

Published
2016

8. Soluble epoxide hydrolase inhibition: a novel therapeutic strategy in alcoholic liver disease.

Author

Warner, Jeffrey Barr

Subjects
sEH, sEHi, epoxyeicosanoid, eicosanoid, ALD, TUCB, Medical Pharmacology
Abstract

Emerging evidence suggests that soluble epoxide hydrolase (sEH) inhibition is a valuable therapeutic strategy for the treatment of numerous diseases. sEH rapidly degrades cytochrome P450-produced epoxygenated lipids (epoxy-fatty acids, epFAs), which generally exert beneficial effects on several cellular processes. sEH hydrolysis of epoxy-fatty acids produces dihydroxy-fatty acids which are typically less biologically active than their parent epoxide. sEH inhibition has shown efficacy in treating numerous pathologies associated with non-alcoholic liver disease, yet no efforts to date have tested the efficacy of sEH inhibition in alcoholic liver disease (ALD). Herein, we measured the levels of sEH expression and epFAs in human ALD, and assessed the efficacy of the sEH inhibitor t-TUCB in multiple pre-clinical mouse models of ALD. Mice exposed to ethanol but treated with t-TUCB had decreased liver injury, inflammation, and endoplasmic reticulum (ER) stress compared to controls, an observation that was reproduced in whole-body sEH knockout mice. In vitro, individual epFAs (17,18-EpETE and 19,20-EpDPA) prevented hepatocyte apoptosis/ER stress and endotoxin-induced pro-inflammatory cytokine production in macrophages. These results suggest the ability of sEH inhibition to prevent alcohol-associated liver injury, inflammation, and ER stress, that is potentially mediated by specific epFAs. Future work will determine the efficacy of sEH inhibition in a treatment paradigm of sEH inhibitor administration and further elucidate molecular mechanisms.

Published
2020

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