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Objective: Sarcoidosis is a chronic inflammatory disease that affects many organs and systems, especially the lungs, lymph nodes and musculoskeletal system. Musculoskeletal system involvement patterns in sarcoidosis are not well defined and literature data are limited in terms of clinical features. This study aimed to investigate the clinical and demographic characteristics of sarcoidosis patients with musculoskeletal system involvement. Methods: One hundred and four patients with sarcoidosis who were followed up in our clinic between June 2020 and January 2024 were evaluated retrospectively. Forty-four sarcoidosis patients aged >18 years with objectively detected musculoskeletal system involvement were included in the study. The musculoskeletal system involvement patterns, clinical and laboratory findings, and demographic characteristics of the patients were analyzed. Results: Musculoskeletal involvement was found in 44 of the 104 sarcoidosis patients (42%). Of the 44 patients with musculoskeletal involvement, 37 (77.3%) were female, the mean age was 46.9±12.2 years, and the mean follow-up time was 14±11.8 months. The most common objective musculoskeletal pathology was chronic arthritis (17%), mostly in the form of chronic oligoarthritis. Wrist (50% vs. 3.8%, p=0.001) and metacarpophalangeal joint involvement (38.9% vs. 0, p=0.001) were significantly higher in patients with chronic arthritis than in patients with acute arthritis. While joint involvement starting as monoarthritis was an independent negative predictor for the development of chronic arthritis [odds ratio (OR): 0.046, 95% confidence interval (CI): 0.003-0.815, p=0.036], the presence of obesity at baseline was a positive predictor for the development of chronic arthritis (OR: 11.968, 95% CI: 1.069-133.960, p=0.044). Conclusion: Sarcoidosis can present with a wide range of musculoskeletal manifestations. The most common musculoskeletal pathologies in sarcoidosis are acute and chronic arthritis. Sarcoidosis patients presenting with monoarthritis do not usually develop chronic arthritis. Patients with chronic sarcoid arthritis initially present more hand-joint involvement. Obesity is a risk factor for the development of chronic arthritis. [ABSTRACT FROM AUTHOR]

Objective: Granulomatous dermatitis (GD) is a group of diseases grouped under two main headings: infectious and non-infectious, characterized histopathologically by granulomas and may also present with systemic findings. Granulomatous inflammation may be limited to the skin only or may occur as a symptom of a systemic disease. Material and Methods: 105 patients included who were clinically and histopathologically diagnosed with non-infectious GD in our clinic between 2006 and 2023. Results: Of the 105 patients included in our study, 79 were female and 26 were male. The mean age of the patients was 45.72 (age range 2-77). While 12 of the patients were under the age of 18, 12 patients were over the age of 65. The diagnosis of the patients were granuloma annulare (n=43), followed by sarcoidosis (n=24), necrobiosis lipoidica (n=12), interstitial GD (n=6), granulomatous rosacea (n=5), panniculitis (n=5), granuloma fasciale (n=2), Crohn’s disease (n=2), granulomatous vasculitis (n=2), piyoderma gangrenozum (n=1), post herpetic GD (n=1), lupus miliaris disseminatus faciei (n=1), granulomatous mycosis fungoides (n=1) and elastolytic giant cell granuloma (n=1). Conclusion: GDs are a heterogeneous group of diseases with varying clinical and histopathological findings. Histopathological morphology alone is rarely specific and is not sufficient to make a definitive diagnosis of the disease that plays a role in etiology. Conclusion: Differential diagnosis of GDs should be made in the light of histopathological findings, microbiological examination and clinical data. [ABSTRACT FROM AUTHOR]

Copyright of Ahi Evran Medical Journal is the property of Ahi Evran University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Namık Kemal Tıp Dergisi is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This case study describes a 67-year-old female patient who presented with shortness of breath and quick exhaustion. In 2018, initial symptoms led to a diagnostic thoracic CT scan, which confirmed sarcoidosis using endobronchial ultrasound (EBUS). Despite the diagnosis, the patient did not receive treatment. A 2023 bone marrow biopsy revealed that the disease had progressed to include heart failure and thrombocytopenia. Transthoracic echocardiography (TTE) was used for cardiological examination, which revealed impaired left ventricular wall motion. Magnetic resonance imaging (MRI) revealed severe cardiac involvement by detecting full-thickness late gadolinium enhancement (LGE) in the left ventricle. This case report emphasizes the complexity and diversity of sarcoidosis symptoms, supporting a multidisciplinary approach for correct diagnosis and individual treatment approach. [ABSTRACT FROM AUTHOR]

Aim: Sarcoidosis is a systemic inflammatory disease and characterized by the presence of non-caseating granulomas which may affect all organs in the body. Some studies suggest an association between peptides and sarcoidosis. The goal of the study was to investigate the biomarker values of serum hemokinin-1 (HK-1) and adropin levels in sarcoidosis and to assess their role in the disease course. Patients and Methods: The study was carried out in a university hospital between April 2021 and February 2022. Thirty-eight patients with diagnosed sarcoidosis (14 men and 24 women) and 38 healthy (14 men and 24 women) individuals were enrolled in the study. Demographic characteristics, age, gender, disease duration, and extrapulmonary involvement of the patients were enrolled. HK-1 and adropin levels were measured via the sandwich ELISA (enzyme linked immunosorbent assay) method. Results: HK-1 level was elevated in the sarcoidosis patients than in the healthy individuals, these differences were significant statistically (0.67±0.23 and 0.54±0.24 ng/ml, p=0.012). The serum levels of adropin were measured as 207.84±246.72 ng/L in the sarcoidosis patients group and 151.16±171.76 ng/L in the healthy individuals group. No significant differences were determined in terms of the adropin levels in the patient's group when compared to the healthy individuals group (p=0.076). Serum adropin were negatively correlated with BAL CD4+ levels (r=-,880 and p=0.002) and positively correlated with BAL CD8+ levels (r=,697 and p=0.037). Conclusions: At the study, it is determined that patients with sarcoidosis show significantly higher HK-1 levels than healthy controls, and HK-1 may be a useful non-invasive diagnostic biomarker for this disease. From the literature, serum HK-1 and adropin levels have not been investigated in sarcoidosis, yet. To clarify this topic, further and larger size studies are needed.

Aim: Sarcoidosis is a systemic inflammatory disease and characterized by the presence of noncaseating granulomas which may affect all organs in the body. Some studies suggest an association between peptides and sarcoidosis. The goal of the study was to investigate the biomarker values of serum hemokinin-1 (HK-1) and adropin levels in sarcoidosis and to assess their role in the disease course. Patients and Methods: The study was carried out in in the Chest Diseases Clinic, Faculty of Medicine hospital, Necmettin Erbakan University, Konya between April 2021 and February 2022. Thirty-eight patients with diagnosed sarcoidosis (14 men and 24 women) and 38 healthy (14 men and 24 women) individuals were enrolled in the study. Demographic characteristics, age, gender, disease duration, and extrapulmonary involvement of the patients were enrolled. HK-1 and adropin levels were measured via the sandwich ELISA (enzyme linked immunosorbent assay) method. Results: HK-1 level was elevated in the sarcoidosis patients than in the healthy individuals, these differences were significant statistically (0.67±0.23 and 0.54±0.24 ng/ml, p=0.012). The serum levels of adropin were measured as 207.84±246.72 ng/L in the sarcoidosis patients group and 151.16±171.76 ng/L in the healthy individuals group. No significant differences were determined in terms of the adropin levels in the patient’s group when compared to the healthy individuals group (p=0.076). Serum adropin were negatively correlated with BAL CD4+ levels (r=-,880 and p=0.002) and positively correlated with BAL CD8+ levels (r=,697 and p=0.037). Conclusions: At the study, it is determined that patients with sarcoidosis show significantly higher HK-1 levels than healthy controls, and HK-1 may be a useful non-invasive diagnostic biomarker for this disease. From the literature, serum HK-1 and adropin levels have not been investigated in sarcoidosis, yet. To clarify this topic, further and larger size studies are needed. [ABSTRACT FROM AUTHOR]

Objective: Fatigue is considered a frequent and characteristic feature of sarcoidosis. This study was designed to determine the prevalence of fatigue in patients with sarcoidosis and to determine its potential clinical correlations in relation to symptom severity. Methods: A total of 56 sarcoidosis patients were included. Data on patient demographics, anthropometrics, disease characteristics, pulmonary function tests, 6-min walking distance (6MWD), blood biochemistry and hemogram findings were retrieved from hospital records. Psychometric instruments involved fatigue assessment scale (FAS), Beck Depression Inventory (BDI) and Short Form-36 (SF-36) for health-related QOL (HRQOL). Results: Mean±SD patient age was 50.9±11.9 years. Of 56 patients, 44 were females and 12 were males. When compared to FAS score <22 and FAS score ≥22-34 subgroups, FAS score ≥35 (severe fatigue) subgroup was associated with significantly higher patient age and significantly lower SF-36 physical health scores. Total FAS scores were correlated positively with age (r=0.349, p=0.008) and BDI scores (r=0.515, p<0.001), while negatively with MIP (r=-0.321, p=0.019) and SF-36 physical health (r=-0.402, p=0.003) and mental health (r=-0.351, p=0.009) scores. BDI score (OR 1.146, 95% CI: 1.020 to 1.288, p=0.021) was determined to be the single independent predictor of increased likelihood of a patient with sarcoidosis to have FAS score ≥22. Conclusions: Our findings emphasize that deterioration in respiratory functions may contribute to development of fatigue among sarcoidosis patients, and besides the fatigue, depressive symptoms and anxiety should also be an integral part of the multidisciplinary management of sarcoidosis patients. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a chronic, multisystem and noncaseating granulomatous disease of unknown etiology. Its diagnosis is based on a combination of clinical and radiographic findings and the demonstration of typical granulomas, and can often be made based on the exclusion of other granulomatous diseases. There is lung involvement in 90% of cases, often in the form of parenchymal disease, while involvement in the form of an endobronchial mass is a rarer condition. Our patient underwent bronchoscopy after being diagnosed with sarcoidosis around 3 years earlier, and was followed up without treatment due to a history of pneumonia that had recurred three times in the same localization in the previous year. An endobronchial lesion was identified on bronchoscopy, while a biopsy revealed granulomatous inflammation. Progressive sarcoidosis was considered based on the clinical and radiological findings and the patient was started on steroid treatment. We present this study of a case of sarcoidosis with recurrent pneumonia in the same localization and endobronchial involvement to emphasize the need to consider sarcoidosis in the differential diagnosis of endobronchial mass lesions. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a chronic granulomatous multisystem disease that often progresses with lung, lymph nodes, skin and eye involvement, while bone involvement may occur more rarely. All bones can be affected, however, although the short bones, such as fingers and toes, are the most commonly affected, while vertebral involvement is rare. Bone involvement is usually determined incidentally due to the asymptomatic course of the disease. We present here the case of a 62-year-old female osseous sarcoidosis case who was diagnosed with pulmonary sarcoidosis seven years earlier and re-evaluated in our clinic due to recently developed low back pain. [ABSTRACT FROM AUTHOR]

Objective: Patients with sarcoidosis may present with cutaneous lesions or other systemic involvement, particularly pulmonary. In this study, we investigated our hypothesis that the clinical course of sarcoidosis patients who present with skin involvement be different. Methods: Fifty-two sarcoidosis patients who applied to our rheumatology outpatient clinic were included in the study. Data on demographics, smoking status, angiotensin converting enzyme (ACE) level at the time of diagnosis, other organ involvement and lung involvement stages were collected. We then compared the clinical and demographic characteristics of patients with and without skin involvement and patients with skin involvement at first presentation, and others separately. Results: While the initial involvement was lung involvement in 28 (53.5%) patients, 19 (36.5%) patients applied to the clinic with skin involvement as a presenting feature. In 23 (44.2%) patients, skin involvement was present at any time during the disease. In our study, the most common skin involvement was erythema nodosum observed in 9 patients (17.3%). Demographic and clinical findings of patients presenting with skin findings did not differ significantly from other patients. High ACE levels were more common in patients without skin involvement than in patients with skin involvement. Conclusion: Even if the clinical course does not differ in sarcoidosis patients presenting with cutaneous involvement, it is important to recognize the cutaneous manifestations of sarcoidosis. We would like to emphasize that detailed physical examination is important, as easily overlooked, small and asymptomatic lesions are the most appropriate site for histopathological diagnosis of sarcoidosis. [ABSTRACT FROM AUTHOR]

Aim: Chest radiography and thoracic computed tomography (CT) play an important role in the diagnosis and prognosis of sarcoidosis, a systemic granulomatous disease characterized by non-caseating granulomas. Pulmonary hypertension, a rare complication of the disease, can be seen in all stages. There is a strong correlation between pulmonary hypertension (PH) and an increase in the diameter of the main pulmonary artery (MPAD). In this study, we aimed to evaluate MPAD with multislice computed tomography (CT) examination for the early diagnosis of PH in patients with stag e II sarcoidosis. Patients and Methods: We measured the diameter of the main pulmonary artery on thorax CT in patients with stage II sarcoidosis, who were followed up in our hospital with a diagnosis of sarcoidosis between January-2018 and December-2021, with hilar lymphadenopathy and parenchymal changes in their imaging, and compared them with the control group, whose chest X-ray was normal and thorax CT scan was performed with nonspecific symptoms. We evaluated the relationship between the pulmonary artery pressures obtained by echocardiography and the diameter of the main pulmonary artery in patients with stage II sarcoidosis Results: We found a significant correlation between the increase in MPAD and pulmonary artery pressure measured by ECHO in patients with sarcoidosis compared to the control group, and the pulmonary artery diameter measured by CT in this patient group. Conclusion: We think that CT evaluation of pulmonary artery diameter in patients with sarcoidosis can guide the development of PH and therefore offer an opportunity for early intervention. [ABSTRACT FROM AUTHOR]

The differential diagnosis of silicosis includes sarcoidosis, berylliosis, hypersensitivity pneumonia, malignancy, tuberculosis and other granulomatous infections. Sarcoidosis is a systemic granulomatous disease with an unknown etiology, although it is thought that occupational exposure to such substances as silica and beryllium may be a trigger. An incomplete occupational history may lead to a diagnosis of sarcoidosis rather than pneumoconiosis in many cases, although various associations of these two diseases, such as the coexistence and detection of one before or after the other, have been reported in literature. The coexistence of sarcoidosis and silicosis is discussed in the present study with reference to five cases who applied to the Occupational Diseases department of a university hospital. Active pulmonary tuberculosis and lung malignancy were excluded in all cases, and histopathologic examinations of all samples were reported as non-caseating granulomatous inflammation. In the specimen of one case, a birefringent body was identified upon polarized microscopy. In the light of these cases, it is aimed to draw attention to the usefulness of a wellreceived occupational history in the differential diagnosis and etiology of sarcoidosis and silicosis. [ABSTRACT FROM AUTHOR]

We report here on the successful management of a patient who developed dyspnea after an elective arthroscopic procedure and who was diagnosed with Negative Pressure Pulmonary Edema (NPPE). A 29-year-old male patient with no known medical history was admitted to our hospital due to a rotator cuff tear sustained during a military operation. An arthroscopic procedure under general anesthesia was performed; however, the patient developed dyspnea 2 hours after extubation. He was desaturated, tachypneic and began to produce frothy pink sputum. Pulmonary computed-tomography angiography revealed widespread ground-glass opacities in both lungs suggesting non-cardiogenic pulmonary edema without acute pulmonary thromboembolism. The patient was thus diagnosed with NPPE and treated with non-invasive mechanical ventilation, intravenous furosemide and inhaled short-acting beta-agonists. Significant recovery was observed in a couple of days, and the patient discharged after his respiratory symptoms abated. NPPE should immediately be suspected in individuals who develop respiratory failure following extubation, as it can be life threatening. [ABSTRACT FROM AUTHOR]

Objective: Cardiac sarcoidosis (CS) can manifest with different clinical signs and has a poor prognosis, but the heart is rarely affected alone. We aim to evaluate the arrhythmogenic effects of sarcoidosis by using electrocardiography (ECG) in patients with or without cardiac involvement. Materials and Methods: A total of 61 patients under follow-up for pulmonary sarcoidosis were retrospectively reviewed and 50 healthy volunteers were enrolled in the study. Sarcoidosis patients were also grouped as with or without cardiac involvement (n=11/ n=35). QRS, QT, Tp-e, P wave morphology were measured manually. Then, Tp-e/QT, Tp-e/QTc, QT/QRS (index of cardiac electrophysiological balance), and QTc/QRS ratios were calculated and compared between groups. Results: Heart rate on ECG, QT/QTc interval, Tp-e intervals and Tp-e/QT ratio and PWD were significantly higher (p values < 0.018) and iCEB or iCEBc values, obtained with the QT/QRS ratio, were lower in the sarcoidosis group (p = 0.001). And we could not find a relationship between non-cardiac and CS and ECG parameters including QTc, Tp-e/QT ratio and iCEB (p= 0.501, p= 0.753 and p=0.490, respectively). Conclusion: The present study demonstrated a lower iCEB value and higher repolarization findings in sarcoidosis patient. However, there are no differences between with or without cardiac involvement.

Sarcoidosis is a disease of unknown etiology which can affect the lungs and lymph nodes, skin, eyes and other organs and, in rare cases, bones and bone marrow cells. We present a case of a 39-year-old male patient with an iliac bone involvement of sarcoidosis mimicking malignancy. Lymphoma and metastatic cancer proved a challenge to discard in differential diagnosis. He underwent multiple biopsies including tru-cut lung parenchyma and iliac bone biopsies. All of the biopsy specimens were reported as non-necrotising granulomatous inflammation. He underwent corticosteroid treatment. His response to the steroid treatment was insufficient so methotrexate was added to the corticosteroid therapy. Afterwards, clinical and radiological improvement was recorded. We aimed to highlight the utilization of taking new biopsies and histopathological re-evaluations in order to confirm the diagnosis and distinguish a benign disease from a malignant one. [ABSTRACT FROM AUTHOR]

Introduction: The etiology and pathogenesis of sarcoidosis, a systemic granulomatous lung disease affecting many people, still remain unknown. Sarcoidosis is diagnosed by demonstrating non-caseous granulomas and ruling out granulomatous diseases. Therefore, sensitive biomarkers used in diagnosis and follow-up processes are needed. Our aim is to investigate diagnostic value of plasma protachykinin-1 (TAC1) levels in sarcoidosis patients.Methods: Forty-two sarcoidosis patients followed-up by the department of chest diseases, and 38 controls were included into the study. Clinical, radiological and laboratory data of patients were recorded, and plasma TAC1 levels were analyzed in patients and healthy controls.Results: Plasma TAC1 levels of sarcoidosis patients and controls were found as 1124.25±1117.25 ng/L and 1319.37±1357.38 ng/L, respectively. Although not statistically significant (p=0.338), a decrease was found in TAC1 levels of sarcoidosis patients. Additionally, patients’ lymphocyte levels were also found significantly lower than controls (p=0.007). No statistically significant correlation was found between other laboratory findings, including leukocyte, neutrophil, monocyte, eosinophil count, cluster of differentiation 4 (CD4) CD4 +, CD8 +, bronchoalveolar lavage (BAL) CD4 +, BAL CD8 + and neutrophil/lymphocyte ratio (NLR), and plasma TAC1 levels.Conclusions: To the best of our knowledge, our study is the first to investigate plasma TAC1 levels as a biomarker in sarcoidosis patients. Although plasma TAC1 levels were slightly decreased in sarcoidosis patients, the decrease was not statistically significant, and no adequate data were provided for the use of plasma TAC1 level as a biomarker. We consider more comprehensive research are needed to elucidate the entity.

A pathophysiological link may exist between Birt-Hogg-Dubé syndrome (BHD) and pulmonary sarcoidosis such that the folliculin protein encoded by the FLCN gene may lead to the development of sarcoidosis through the upregulation of T- helper 1 cell activation. We present here a rare case of coexisting BHD and sarcoidosis. Enlarged mediastinal lymphadenopathy may be underdiagnosed in patients with BHD, and so both the mediastinal and lung window of a thoracic CT scan should be evaluated carefully and a biopsy should be performed if pathologic lymphadenopathies are indicated. [ABSTRACT FROM AUTHOR]

Aim: The decision of treatment in sarcoidosis is made based on clinical and radiological findings and changes in pulmonary function test findings during follow-up, and more useful tools are needed. F-18 fluorodeoxyglucose (18F-FDG) positron required important tomography/computed tomography (PET/CT) contains information about the extent of sarcoidosis. Neutrophil/lymphocyte ratio (NLR) opens as a prognostic marker for inflammation. This study evaluated the relationship between the 18F-FDG PET/CT findings of sarcoidosis and NLR and other clinical findings. Patients and Methods: The data of patients who were diagnosed with sarcoidosis after 18F-FDG PET/CT scan in our clinic between January 2017 and December 2019 were reviewed retrospectively. Patients' age, gender, NLR values, smoking status, extrathoracic involvement and symptoms, and 18F-FDG PET/CT findings were compared. Results: This study consisted of 41 patients. There were strong correlations between NLR and whole body total lesion glycolysis (TLG), and moderate correlation between MAIA (r values: 0.852, 0.660, both of them p value: <0.001, respectively). There were significant differences between thoracic involvement and extrathoracic involvement with MAIA, TLG and NLR values (p values,: 0.002, 0.001 and, 0.003, respectively). According to the symptoms of the patients, there was no significant difference between the groups with SUVmax, MAIA, TLG and NLR values. Median values were found to be significantly higher in the elderly group (p values: 0.037 and 0.040, respectively). Were no significant differences in both PET/CT parameters and NLR values. Conclusion: The close relationship between the NLR value, which is accepted as a prognostic indicator in sarcoidosis, and the 18F-FDG PET/CT findings which show the involvement of the disease in the whole body, may provide the clinicians with significant benefits in treatme nt management. [ABSTRACT FROM AUTHOR]

Aim: Sarcoidosis is a multifactorial disease with unknown aetiology and characterized by non-caseous granulomatous inflammation. The pathogenesis of sarcoidosis is defined as inflammation and autoimmune activation. Here, we aimed to evaluate plasma clusterin (CLU) and a-klotho levels in those with sarcoidosis. Patients and Methods: Forty patients with sarcoidosis (mean age: 52.10±12.60 years; 12 males, 28 females) and 40 healthy volunteers (mean age: 37.40±18.20 years; 12 males, 28 females) between November 2019-March 2020 were enrolled into the study. Blood samples were drawn from both groups, and plasma CLU and α-klotho levels were investigated by enzyme-linked immunosorbent assay (ELISA) technique. Results: Patients with sarcoidosis had significantly higher plasma CLU levels (309.73±40.68 ng/mL), compared with healthy controls (117.86±102.03 ng/mL) (p=0.005). The plasma levels of α-klotho were measured as 5.34±7.30 in the sarcoidosis patients and 7.21±9.84 ng/mL in the controls. A minimal decrease was observed, but there was no statistically significant difference (p=0.338). The hemoglobin levels of sarcoidosis patients were decreased, when compared with the control group (12.93±1.02 g/dL vs 14.06±1.50 g/dL) (p=0.012). Conclusion: We concluded that sarcoidosis is associated with high levels of CLU. Plasma CLU may be a potential biomarker of sarcoidosis. Based on literature and to the best of our knowledge, this is the first study to provide insight in the determination of plasma levels of CLU and α-klotho in sarcoidosis. Further and comprehensive investigations are needed to clarify the entity. [ABSTRACT FROM AUTHOR]

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Copyright of Current Retina Journal / Güncel Retina Dergisi is the property of Anadolu Kitabevi Basim Yayim Medikal Turizm Kirtasiye Tic. Ltd. Sti. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Amaç: Literatürde “büyük taklitçi” olarak anılan inflamatuar bir hastalık olan sarkoidoz olgularında semptomlar ve tutulan organlar açısından cinsiyete göre farklılıklar bildirilmiştir. Bu çalışmada sarkoidoz olgularındaki semptom ve bulguların cinsiyete ve hastalığın evrelerine göre farklılıkları araştırıldı.Gereç ve Yöntemler: Bu retrospektif gözlemsel kohort çalışmamızda sarkoidoz tanılı olgular başvuru semptomlarına göre; asemptomatik, pulmoner semptomlar, ekstrapulmoner semptomlar, pulmoner ve ekstrapulmoner semptom birlikteliği olarak gruplandırıldı. Her iki cinsiyet bulguların sıklığı açısından karşılaştırıldı.Bulgular: Çalışmaya alınan 338 hastanın %71’i kadın olup yaş ortalaması 42,5±11,6 idi. Olguların %86’sı başvuru anında semptomatik olup, semptomların %31’i yalnız pulmoner, %23’ü yalnız ekstrapulmoner, %32’sinde ise hem pulmoner hem de ekstrapulmoner semptomlar birlikte idi. Kadın ve erkeklerde öksürük (sırasıyla %45; %42; p=0,620), balgam çıkarma (sırasıyla %9; %11; p=0,535), hemoptizi (sırasıyla %2; %1; p=0,678), ateş (sırasıyla %4; %4; p=0,999) bulguları açısından cinsiyete göre anlamlı farklılık bulunamadı. Dispne kadınlarda erkek olgulara göre anlamlı olarak daha sık izlendi (sırasıyla %33; %22; p=0,048). Kadın hastalarda erkeklere kıyasla göğüs ağrısı anlamlı olarak daha az görüldü (sırasıyla %7; %20; p=0,001). Aşırı terleme erkeklerde kadınlara göre anlamlı olarak daha fazla görülürken (p=0,004), eritema nodosum kadınlarda erkeklere göre fazla bulundu (p=0,003). Terleme dışındaki konstitüsyonel yakınmalarda cinsiyet farkı izlenmedi.Sonuç: Sarkoidozlu kadınlar daha yaşlıdır ve nefes darlığı ile eritema nodosum, kadınlarda erkeklere göre anlamlı oranda sık bulunmuştur. Erkeklerde ise terleme ve göğüs ağrısı belirgin yüksek tespit edilmiştir.

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Objective: The aim of this present study was to investigate the eating attitudes of sarcoidosis patients. Methods: 50 patients with sarcoidosis and 45 healthy individuals without chronic disease were included to study. All participants evaluated for metabolic syndrome (MetS) according to National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) criteria. Eating Attitude Test (EAT) and Beck Depression Inventory (BDI) were applied to all participants. All participants evaluated for metabolic syndrome (MetS). The cut-off scores of the tests were 30 for BDI and 17 for BDI. Results: When sarcoidosis cases and control group were evaluated according to EAT and BDI cut-off scores; it was found that the prevalence of deterioration in eating behavior was higher in patients with sarcoidosis than healthy controls but the prevalence of depression was not higher (p=0.018, p=0.874 respectively).We found that total EAT scores were significantly higher in sarcoidosis patients who has MetS. MetS(-); EAT: 15±7, MetS(+); EAT: 27±10 p<0.001. Conclusions: This study is important to show connection between the sarcoidosis and disordered eating attitudes. It is not adequate to establish the presence of comorbidities alone. Defining risk factors leading to comorbidities is also important in patients with sarcoidosis. If causative factors are detected, controlling them by a multidisciplinary approach will prevent the onset of comorbidities and also provide satisfactory management of sarcoidosis. [ABSTRACT FROM AUTHOR]

Elli dokuz yaşında kadın hasta 3 haftadır devam eden kuru öksürük ve 2 aydır olan efor dispnesi (MRC 2) ile polikliniğimize başvurdu. Son 3 ay içerisinde 5 kg kaybı mevcuttu. Hiç sigara içmemişti. Mesleği ev hanımı idi. Hastanın postero-anterior akciğer grafisinde sağ alt zonda sağ atriyum kenarını silen opasite olması üzerine çekilen toraks bilgisayarlı tomografisinde; her iki akciğer üst loblarda büyüğü 5 mm olmak üzere birkaç adet nodül, solda lingula ve sağda orta lobda yine yaygın retikülonodüler dansiteler izlendi. Hastanın malignite ön tanısıyla istenen pozitron emisyon tomografisinde; nazofarenks dorsal duvarında, bilateral servikal lenfadenopatilerde, her iki akciğerde parankim nodüllerinde, sağ akciğer hiler alanda, sol akciğerde retiküler dansitelerde, gastroözafagial bileşkede, mide fundus ve büyük kurvaturunda, karaciğerde, iliak istasyonlarda multipl lenfadenopatilerde, sağ skapula ve sol iliak kemik iliğinde yoğun hipermetabolik tutulum saptandı. Yapılan axiller lenf nodu diseksiyonu granülomatöz lenfadenit olarak saptandı. Hasta sarkoidoz olarak kabul edildi, inhale steroid tedavisi başlandı ve takibe alındı.

Sarcoidosis is a disease characterized by noncaseating granulomas that can affect many tissues and organs, especially the lungs. In sarcoidosis, osteopenia, osteoporosis and pathological bone fractures can be seen with the direct effect of granulomas, osteoclast activating factors such as 1.25-dihydroxyvitamin D released from macrophages, and the use of glucocorticoids. Bone involvement of sarcoidosis produces typical cystic structures in the hands and feet. Vertebral involvement is rare and may cause lytic, sclerotic or mixed lesions. It should be differentially diagnosed from metastatic lesions. [ABSTRACT FROM AUTHOR]

Objective: The association of lymphopenia detected in patients with sarcoidosis with disease activity was investigated in the present study. Methods: Patients who were diagnosed as having sarcoidosis and healthy volunteers/individuals with no diagnosis of active disease between July 2016 and June 2017 were included in this study. Patients who were detected to have an absolute lymphocyte count (ALC) of <1.3 × 10?/mm? were accepted as lymphopenic patients. The detection rates of lymphopenia were compared between two groups. The respiratory function testing-diffusing capacity of the lungs for carbon monoxide (RFT-DLCO) levels and the high-resolution computed tomography (HRCT) results of patients with and without lymphopenia in the sarcoidosis group were compared. Results: In the sarcoidosis group, 77 patients were included, and in the control group, 41 patients were included. The number of lymphopenic patients in the sarcoidosis group was 21 (27.2%), and that in the control group was 1 (2.4%) (p=0.001). The percentaged DLCO value of 33 patients (28%) was below 80%; however, the percentaged DLCO value of 44 patients was higher than 80% in the sarcoidosis group. The mean ALC of patients in the sarcoidosis group who had a DLCO value of <80% was 1.6±0.7; however, the mean ALC of patients who had a DLCO value of >80% was 2±0.7 (p=0.016). A positive correlation was detected between ALC and DLCO% (p=0.044, r=0.230). Although lymphopenia was detected in 42% of patients whose DLCO value was <80%, lymphopenia was detected in 15% of patients whose DLCO value was >80% (p=0.01). No significant association was detected among the sarcoidosis stage, symptom, and radiologic findings of the patients with the absolute lymphocyte count (p>0.05). Conclusion: Lymphopenia is frequently detected in patients with sarcoidosis. Lower DLCO values may be detected in patients with lymphopenic sarcoidosis. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a granulomatous disease of unknown origin, which affects many organs and systems, and is often seen in young adults. The most common organ involved in sarcoidosis is the lung and various radiological features are observed. Bilateral hilar lymph node enlargement is the most common finding, followed by interstitial lung disease. Primer cavitary sarcoidosis is very rare. In this article, we present a case of sarcoidosis diagnosed by mediastinoscopy who had a history of contact with tuberculosis and diffuse cavitary lung lesions and hilar lymphadenopathies on thoracic computed tomography. Sarcoidosis should be kept in mind in the differential diagnosis of cavitary lesions of lung. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Internal Medicine / Türkiye Klinikleri İç Hastalıkları Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: The aim of this study was to investigate the diagnostic value of endobronchial ultrasonography (EBUS) and factors associated with diagnosis in patients with lung sarcoidosis. Methods: In this prospective study, EBUS transbronchial needle aspiration (TBNA) was performed for patients with a clinical and radiological suspicion of pulmonary sarcoidosis with enlarged hilar/mediastinal lymph nodes detected on a computerized tomography scan of the chest between January 2014 and September 2015. Results: During the study period, 107 patients underwent EBUS-TBNA and 1 patient underwent transesophageal endoscopic ultrasonography with fine needle aspiration (EUS-FNA). Four cases determined to be non-sarcoidosis (tuberculosis) were excluded from the study. Of the 104 cases definitively diagnosed as sarcoidosis, 28.8% were male patients and 71.2% were female, with a mean age of 44.3±13.1 years. A total of 92.3% of the patients (n=96) were diagnosed with EBUS-TBNA and 1% (n=1) was diagnosed based on EUS-FNA results. EBUS was nondiagnostic in 7 patients and sarcoidosis was diagnosed by mediastinoscopy in 6 patients and by right supraclavicular lymph node biopsy in 1 patient. The sensitivity of EBUS-TBNA was 92.3%, with a specificity of 100%. Conclusion: EBUS-TBNA has a high sensitivity and specificity for demonstrating granulomatous inflammation in cases of suspected sarcoidosis. Given the high diagnostic rate of EBUS-TBNA, additional invasive procedures may be unnecessary. [ABSTRACT FROM AUTHOR]

Copyright of Turkiye Klinikleri Journal of Health Sciences / Türkiye Klinikleri Sağlık Bilimleri Dergisi is the property of Turkiye Klinikleri and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sarkoidoz sistemik granülomatöz bir hastalıktır ve en sık akciğerleri tutar, nadir olarak kemik iliği tutulumu ile seyredebilir. Kemik iliği tutulumu olan hastalarda hematolojik anormallikler saptanabilmektedir. 47 yaşında bel ağrısı, yürümede güçlük ve çift taraflı alt ekstremitelerde güçsüzlük şikayetleri olan bayan hastada bisitopeni ve L2-L3 vertebrada lezyon saptandı. Hasta opere edildi. Lezyonun patolojik incelemesi sonucu sarkoidoz tanısı kondu. Yapılan diğer incelemeler sonucunda Akciğerde sarkoidoz tutulumu saptandı. 74 yaşında halsizlik ve yorgunluk şikayetleri olan bayan hastada yapılan tetkiklerde pansitopeni saptanması üzerine kemik iliği biyopsisi yapıldı. Kemik iliğinin patolojik olarak incelemesi sonucunda sarkoidozla uyumlu non-kazeifiye granülom saptandı. Yapılan diğer incelemelerde başka bir tutulum saptanmadı. Burada nadir görülen kemik iliği sarkoidozu saptanan iki olguyu sunduk.

Sarcoidosis and amyloidosis can affect many organs, including the heart. The diagnosis of cardiac sarcoidosis and amyloidosis is very important because the prognosis of the patient depends on cardiac involvement and early treatment. Radionuclide molecular imaging plays an important role in the evaluation of these patients. Advances in noninvasive imaging methods have reduced the need for endomyocardial biopsy in patients with sarcoidosis and amyloidosis. Early diagnosis and appropriate treatment of cardiac sarcoidosis improve the prognosis of patients. F-18 fludeoxyglucose positron emission tomography (PET) imaging in patients with cardiac sarcoidosis is useful in diagnosis, prediction of risk and prognosis, choice of treatment, and in monitoring the response to treatment. PET imaging with somatostatin analogues in cardiac sarcoidosis shows promising results. Identification of myocardial involvement in amyloidosis and discrimination of amyloid subtypes is the most important step. Bone scintigraphy and PET imaging with amyloidspecific tracers may be an appropriate choice to identify cardiac amyloidosis and differentiate subtypes. In this review, radionuclide molecular imaging in cardiac sarcoidosis and cardiac amyloidosis is described. [ABSTRACT FROM AUTHOR]

A 60-year-old female with no significant medical history presented with hematuria. A computed tomography (CT) scan revealed extensive lymphadenopathy with hypodensities in the liver and spleen, and she was referred for an 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/CT (PET/CT) study to assess for malignancy of unknown primary. PET/CT revealed extensive 18F-FDG avid lymphadenopathy as well as innumerable intensely 18F-FDG avid lung, liver and splenic nodules, highly concerning for malignancy. A PET-guided bone marrow biopsy of the posterior superior iliac spine revealed several nonnecrotizing, well-formed granulomas, consistent with sarcoidosis. The patient was managed conservatively and remained clinically well over the subsequent 9 years of follow-up. [ABSTRACT FROM AUTHOR]

Pneumothorax is a rare entity in the course of sarcoidosis, yet the rupture of subpleural blebs or bullae or the necrosis of subpleural granulomas may be pathogenic agents responsible for spontaneous pneumothorax. In the case presented, there was intense initial pulmonary paranchymal involvement in the bilateral lung zones. Though there was a good clinical and radiological response to systemic corticosteroid therapy, unilateral pneumothorax occurred following 2 months of treatment. A tube thoracostomy and underwater sealed drainage was performed. This case is presented with a discussion of the literature as a rare example of sarcoidosis. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a chronic granulomatous disease characterized by noncaseating granuloma formation. It usually involved the lung, skin, eye, and locomotor system, as well as exocrine glands, and can mimic the primary Sjögren syndrome. Herein we report a case of sarcoidosis diagnosed as a result of laboratory, radiological and histopathological examination applied with complaints of parotid gland swelling. [ABSTRACT FROM AUTHOR]

Objective: In cases of pulmonary sarcoidosis, extrapulmonary involvement is not uncommon. The skin, eyes, and lymph nodes are the most common sites of extrapulmonary involvement, and multiple organs may be involved at the same time. In this study, patients with extrapulmonary sarcoidosis were investigated in terms of the localization of involvement. Methods: Patients diagnosed with sarcoidosis between 1994 and 2015 were evaluated retrospectively. Demographic characteristics, symptoms, organ involvement, diagnostic methods, and the length of time between the diagnosis of sarcoidosis and additional organ involvement were recorded. The patients were consulted to the departments of dermatology, ophthalmology, and cardiology, and a chest X-ray, high-resolution computed tomography, and abdominal ultrasound examinations were performed. Results: Extrapulmonary involvement was detected in 144 of a total of 337 sarcoidosis patients. In 92% of those patients with extrapulmonary involvement, there was accompanying pulmonary involvement. Women made up 75% of the group, and the mean age was 43 years. The most commonly detected extrapulmonary involvement was of the skin (n=41), followed by erythema nodosum (n=37), and involvement of the liver (n=24), lymph nodes (n=20), spleen (n=18), and salivary/parotid gland (n=15). The most frequent diagnostic method used was mediastinoscopy (n=41), followed by a skin biopsy (n=23), and a transbronchial lung biopsy (n=19). Of the 26 (18%) patients who had multiple-organ involvement, 2 were diagnosed as stage 0, 14 were stage 1, 9 were stage 2, and 1 was stage 3. The mean length of time before a diagnosis of extrapulmonary involvement was 24 days. Conclusion: If there is extrapulmonary involvement in a case of sarcoidosis, it should be kept in mind that more than 1 organ system may be involved and the relevant additional tests may be required. [ABSTRACT FROM AUTHOR]

Sarcoidosis is a multisystemic, granulomatous disease with particular involvement in the lungs and the intrathoracic lymph nodes. Pleural fluid has been reported to occur in 0% to 5% of the cases in the literature. Diagnosis depends on the presence of noncaseating granulomas in the biopsy sample and the exclusion of other possibilities. A 77-year-old woman with complaints of shortness of breath and a dry cough was found to have non-necrotizing granulomatous inflammation in pleural biopsy and computed tomography guided transthoracic Tru-Cut biopsy specimens. This was a rare case in which partial recovery was achieved through treatment with methylprednisolone for a year in reduced doses. [ABSTRACT FROM AUTHOR]

Granulomatous diseases of the lung may be difficult to diagnose in both pathological and clinical aspects. The most common reasons for granulomatous lung are tuberculosis as an infectious source, and sarcoidosis or hypersensitivity pneumonia (HP) as non-infectious causes. Here, 2 cases of granulomatous lung disease that had been incorrectly diagnosed are described. The first was a 64-year-old female patient diagnosed as HP clinically and radiologically, and the second was a 67-year-old male diagnosed as sarcoidosis pathologically. Both had progression clinically and radiologically under corticosteroid treatment. Repeat bronchoscopic evaluation revealed Mycobacterium tuberculosis in the bronchial lavage polymerase chain reaction/BACTEC (Becton Dickinson and Co., Franklin Lakes, NJ, USA) cultures, and lung tuberculosis treatment was initiated for both patients. These cases are interesting in that granulomatous diseases may have similarities in clinical, radiological, and pathological features, and repetition of tuberculosis microbiological examination is important in the differential diagnosis. [ABSTRACT FROM AUTHOR]

Aim: Sarcoidosis is known as the 'great imitator' for its versatile manifestations which differ among genders. The objective of this study is to investigate the signs and symptoms and differences in respect to gender and phases of disease. Material and Methods: This cohort study includes patients with sarcoidosis classified as asymptomatic, with pulmonary symptoms only, extrapulmonary symptoms only and those with both together. The frequency, prevalence, and severity of the signs and symptoms were compared between gender identities. Results: This study enrolled 338 patients, of which 71% were female, and mean age was 42.5±11.6. Most patients (86%) were symptomatic on presentation, and pulmonary symptoms were noted in 31%, extrapulmonary symptoms in 23% and both in 32%. There were no significant differences between genders regarding cough (45% in women, 42% in men, p=0.620), sputum (9%, 11%, respectively, p=0.535), hemoptysis (2%, 1%, respectively, p=0.678), fever (4%, 4%, respectively, p=0.999). Dyspnea was reported significantly more common in women (33% and 22%, respectively, p=0.048) whilst chest pain was more common in men (7%, and %20 respectively, p=0.001). Excessive perspiration was significantly more common in men, and erythema nodosum in women (p=0.004 and p=0.003, respectively). Frequencies of constitutional symptoms other than perspiration did not differ between sexes. Conclusion: Women with sarcoidosis were older than men and dyspnea and erythema nodosum were seen more commonly in women. Frequencies of other symptoms were similar between sexes. [ABSTRACT FROM AUTHOR]

Giriş: Sarkoidoz başta akciğerler olmak üzere sistemik tutulum yapan granülomatöz bir hastalıktır. Göz oldukça sık tutulan bir organ olup en sık anterior üveit şeklindedir. Olgu: Altmış yaşında kadın hasta polikliniğimize geçirilmiş granülomatöz panüveit atağı öyküsü ile başvurdu. Tanı ve ayırıcı tanıya yönelik yapılan sorgulamada özellik yoktu. Paterji testi negatifti. Laboratuvar incelemesinde rutin biyokimyasal testleri normal, ANA, ANA profili, antidsDNA, ANCA profili, anti CCP ve RF negatifti. Kompleman düzeyleri (C3, C4) normaldi. Serum anjiyotensin dönüştürücü enzim (ACE) seviyesi 71 mg/dL (normal: <40 mg/dL) olarak bulundu. Toraks BT incelemesinde subkarinal alanda en büyüğü 14x10,5 mm boyutlarında olan lenf nodları saptandı. Lenf nodu biyopsisi non-spesifik olarak geldi. Hastaya sarkoidoz tanısı ile 100 mg/gün azatiyopürin ve 64 mg/gün metilprednizolon tedavisi başlandı ancak azatiyopürin tedavisi intolerans nedeni ile sonlandırıldı. Tedaviye 40 mg/2 hafta adalimumab ve 12,5 mg/hafta metotreksat ile devam edildi. Tedavinin dördüncü ayında iki hafta ara ile hasta iki kez daha üveit atağı geçirdi. Bunun üzerine tedavi rituksimab ile değiştirildi. Hastaya şimdiye kadar toplamda 2 gr rituksimab tedavisi uygulanmış olup iki aydır remisyondadır. Sonuç: Sarkoidozun göz tutulumu en sık anterior üveit şeklinde olsa da panüveit tablosu ile prezentasyon olabilir. Dirençli sarkoidoz olgularında anti TNF'lerin kullanımı son yıllarda artış göstermekle beraber tedavi altındayken gelişen paradoksal sarkoidoz olguları literatürde mevcuttur. Bu olgularda farklı etki mekanizmasına sahip biyolojik ajan kullanımı önerilse de rituksimab tedavisi ile ilgili veriler oldukça sınırlı ancak umut vericidir. Tanımladığımız olguda hastanın hem göz hem sistemik bulgularında remisyon sağladığımız için bu olguların tedavisinde rituksimab tedavisini önermekteyiz. [ABSTRACT FROM AUTHOR]

The purpose of reporting this case is to raise the awareness of the rapid worsening clinical presentation of acute pancreatitis in an older patient, unexpected encounter with pancreatic lymphoma, and sarcoidosis-lymphoma syndrome. An 80-year-old woman was diagnosed with sarcoidosis 16 years ago. Following recent hospitalization because of acute pancreatitis, non-obstructive and non-invasive pancreatic mass was found on radiological images. Histopathology confirmed the mass to be diffuse large B-cell lymphoma. We report this case because of its complicated the etiology of acute pancreatitis in an older patient, presentation of pancreatic lymphoma, and immune pathogenesis of sarcoidosis-lymphoma syndrome. [ABSTRACT FROM AUTHOR]

Objective: While the incidence of sarcoidosis peaks between 20 and 39 years, it is comparatively low in elderly subjects. We sought to determine whether there are age-dependent differences in the demographic and laboratory characteristics of patients with sarcoidosis. Materials and Methods: We retrospectively collected information from our database using the International Classification of Disease (ICD) diagnostic code D86 between 2008 and 2014. Patients were divided into three groups: 20-39 years old (Group 1), 40-59 years old (Group 2), and 60-80 years old (Group 3). Results: A total of 3988 patients with code of D86 were included in the study. After the exclusion of non- eligible patients, the number of cases in Groups 1, 2, and 3 were 276, 641, and 352, respectively. The groups were compared according to demographic characteristics, ICD diagnostic codes, and laboratory parameters. The ratio of female patients was significantly higher in Group 3 than in Groups 1 and 2 (p=0.000). There was no difference in diagnostic codes of the ICD subgroups between groups (p=0.19). While the level of blood- urea nitrogen was significantly higher in Group 3 patients than in other groups (p=0.000), serum angiotensin-converting enzyme (ACE) values were found to be significantly low in Group 3 (p=0.010). The mean ACE values did not differ between females and males (50.8±39.3 and 59.1±45.5 mg/dL, respectively) (p=0.18). Conclusion: The majority of patients with sarcoidosis were female in all age groups and pulmonary sarcoidosis was the most common presentation of the disease. Elderly patients (≥60 years) with sarcoidosis had lower serum ACE levels than younger patients. [ABSTRACT FROM AUTHOR]

Objective: We aimed to investigate the importance of mean platelet volume (MPV) as a marker for the activation and severity of disease in patients with pulmonary sarcoidosis. Methods: The data of 84 patients diagnosed with pulmonary sarcoidosis in our clinic between 2011 and 2014 were evaluated retrospectively. Patients were divided into groups according to the activation status (active or in remission), acute or chronic disease, stage according to chest X-ray, and extrapulmonary involvement. The correlation of the initial MPV and ACE levels was evaluated. Results: Sixty-three of the patients were female, with an average age of 44 (38-52) years. Fifty-two of the patients (62%) were in stage 1, and 32 (38%) were in stage 2. The median ACE level was 59.6 (42.6-92), and the MPV level was 10.1 (9.7-10.7). Bronchoalveolar lavage was applied to 24 patients; all of these had predominant lymphocytes, and the median CD4/CD8 rate of the patients was 4.8 (3.2-12.5). A significant negative correlation was detected between ACE and MPV independently of the groups (p<0.038). There were no significant differences in MPV levels between patients whose activation status was active or in remission, between acute or chronic patients, between patients in stage 1 or stage 2, or between patients with or without extrapulmonary involvement (p>0.05 for all). Conclusion: According to our data, MPV is not a significant marker for inflammation or activation of disease and is not suitable for use as a diagnostic and follow-up indicator in pulmonary sarcoidosis. [ABSTRACT FROM AUTHOR]

Tuberculosis (TB) and sarcoidosis are granulomatous diseases with different etiologies and management; however, they have similar clinical and histological characteristics. Coexistence of TB and sarcoidosis is extremely rare. Presently described is a case of coexistence of pulmonary tuberculosis and sarcoidosis confirmed microbiologically and histopathologically. [ABSTRACT FROM AUTHOR]