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Bank Maluku Malut (Malut) is a bank operating in the Malukuku region which also experiences "Non-Performing Loans (NPLs)" problems which can affect the bank's performance and financial health. This study tries to answer the topic of how bank health changes before and after credit restructuring as a form of implementation of OJK policies on the overall health of the bank using a statistical process. The data analysis method applied in measuring the health level of banks is through the use of the "RGEC (Risk Profile, Good Corporate Governance, Earnings, and Capital)" method, where the data is analyzed quantitatively descriptively in evaluating the health levels of banks on each factor and its components. The results of the study show that the level of financial health of capital-based banking before and following credit restructuring varies. The level of health of banking is improving in line with credit restructuring. The findings of this study can inform policymakers and financial institutions about the effectiveness of credit restructuring strategies in maintaining bank health and enhancing compliance with regulatory frameworks. It also offers a framework for assessing the implications of similar policies in other banking contexts, potentially guiding future reforms and strategies in the industry. [ABSTRACT FROM AUTHOR]

Objectives: Schizophrenia is associated with an increased risk of suicide. Few studies have investigated the risk of suicide across different ages, likely due to limitations around sample size. Methods: From the National Health Insurance Research Database in Taiwan, this study identified 195,787 patients with schizophrenia from January 1, 2000, to December 31, 2019. During the study period, 3848 patients died from suicide. We calculated the standardized mortality ratio (SMR) for suicide stratified by age. In this age‐stratified, nested case–control study, risk set sampling was used to match each case with 4 living controls by age, sex, and the year of the first diagnosis with schizophrenia. Conditional logistic regression was used for estimating age‐stratified risk profiles. Results: The SMR was the highest in the <25 years age group (52.8) and inversely correlated with age. Unemployment was associated with an increased risk of suicide in the 25 to 34, 35 to 44, 45 to 54, and 55 to 64 years age groups. Depressive and sleep disorders before suicide were more common among suicide cases with schizophrenia than among controls across all age groups. Drug‐induced and alcohol‐induced mental disorders were significantly associated with suicide but were observed only in the age group younger than 54. Heart disease, pneumonia, and moderate or severe renal disease were risk factors for suicide in the age groups less than 65. Conclusions: The risk factors for suicide differ by age. This study's findings can be used to optimize health‐care interventions for preventing suicide in patients with schizophrenia. [ABSTRACT FROM AUTHOR]

Abstract Background Interventions for preventing or reducing the development of lifestyle-related disorders should be investigated as these conditions are becoming increasingly prevalent and having large effects on quality of life and life expectancy globally. The aim of this pilot study was to prepare for a full-scale randomised controlled trial by evaluating the short-term changes resulting from a function-based preventive intervention aimed at lifestyle-related disorders on a small group of physically inactive 40-year-old people. Change in objectively measured physical activity, functional capacity according to a risk profile, and goal attainment were main outcomes. Methods Participants (n = 27) underwent functional examinations including tests of fitness, strength, mobility, balance, and posture as well as standard medical examinations including weight measures, blood pressure and blood tests and were randomised to two groups. The intervention group (n = 15) received feedback from all the examinations and lifestyle counselling based on a functional profile. The control group (n = 12) received feedback only from the standard medical examination. Follow-up was at 3–4 months. Changes in physical activity measured with accelerometers, functional levels on the functional profile, goal attainment and subjective assessments of health-related quality of life, motivation, function, and physical activity were examined, as were standard medical parameters. Results Change in mean time in moderate or more intense physical activity was 9 min higher in the intervention group (95% confidence interval -6.35, 24.51) and change in sedentary time was 42 min lower (-95.24, 11.32). The intervention group showed a higher increase in motivation for change 1.58 on 10-point scale (0.20, 2.97) and indicated more improvement on the functional risk levels concerning fitness (-0.06, 0.90). Correlation between objectively measured and self-assessed physical activity and function increased after the intervention. Most participants in the intervention group achieved some or all of their goals. Conclusions This small-scale pilot intervention with functional examinations and lifestyle counselling showed positive tendencies for change in short-term physical activity level. It seemed to lead to better understanding of personal functional capacity and increased motivation for lifestyle changes. Setting and fulfilling meaningful goals for lifestyle-related changes seemed to influence levels on the functional profile in positive directions. Research on larger and more diverse populations will be necessary to better understand the implications of the intervention. Trial registration ClinicalTrials.gov: NCT05535296 first posted on 10/09/2022.

Background Methods Results Conclusion Older adults often require surgical care and are at elevated risk of delirium. We explored delirium risk profiles across the population of U.S. older adults who underwent one of 10 common noncardiac surgeries.We analyzed Health and Retirement Study (HRS) participants linked with Medicare billing data who underwent the following 10 noncardiac surgeries from 2000 to 2018 at age 65 or more: total knee arthroplasty (TKA), total hip arthroplasty (THA), spine surgery, cholecystectomy, colorectal surgery, hernia repair (ventral, umbilical, or incisional), endarterectomy, prostatectomy, transurethral resection of the prostate (TURP), and hysterectomy. Demographic and health covariates were obtained from the HRS dataset. Latent cognitive ability was calculated from cognitive testing, proxy reports, and demographics at the preoperative HRS interview. We compared standardized differences for delirium risk factors across the 10 surgeries and qualitatively clustered them into phenotypical subgroups.We analyzed 7424 older adults (mean age 76 ± 6 years, 45% male). Endarterectomy patients presented with the highest burden of nearly all health and cognitive factors, implying higher delirium risk (e.g., stroke, 22%; depressive symptoms, 30%; high school or less education, 73%; frailty, 42%; lowest latent cognitive ability). A second “general surgery” phenotype, including cholecystectomy, colorectal, and hernia surgery patients, experienced more frailty (29%–32%) and depressive symptoms (24%–26%), with moderate comorbidity burden. A third “pain” phenotype, which included TKA, THA, and spine surgery patients, commonly reported moderate or severe pain (47%–53%) and impairment in activities of daily living (ADL, 23%–30%), but fewer comorbid medical conditions. The remaining surgery types (hysterectomy, prostatectomy, TURP) were not phenotypically grouped and generally had lower risk features for delirium.In an epidemiological cohort of US older adults, we identified clinically meaningful heterogeneity in delirium risk profiles across different surgical types, which may have implications for delirium risk stratification and delirium prevention or treatment. [ABSTRACT FROM AUTHOR]

Background: Interventions for preventing or reducing the development of lifestyle-related disorders should be investigated as these conditions are becoming increasingly prevalent and having large effects on quality of life and life expectancy globally. The aim of this pilot study was to prepare for a full-scale randomised controlled trial by evaluating the short-term changes resulting from a function-based preventive intervention aimed at lifestyle-related disorders on a small group of physically inactive 40-year-old people. Change in objectively measured physical activity, functional capacity according to a risk profile, and goal attainment were main outcomes. Methods: Participants (n = 27) underwent functional examinations including tests of fitness, strength, mobility, balance, and posture as well as standard medical examinations including weight measures, blood pressure and blood tests and were randomised to two groups. The intervention group (n = 15) received feedback from all the examinations and lifestyle counselling based on a functional profile. The control group (n = 12) received feedback only from the standard medical examination. Follow-up was at 3–4 months. Changes in physical activity measured with accelerometers, functional levels on the functional profile, goal attainment and subjective assessments of health-related quality of life, motivation, function, and physical activity were examined, as were standard medical parameters. Results: Change in mean time in moderate or more intense physical activity was 9 min higher in the intervention group (95% confidence interval -6.35, 24.51) and change in sedentary time was 42 min lower (-95.24, 11.32). The intervention group showed a higher increase in motivation for change 1.58 on 10-point scale (0.20, 2.97) and indicated more improvement on the functional risk levels concerning fitness (-0.06, 0.90). Correlation between objectively measured and self-assessed physical activity and function increased after the intervention. Most participants in the intervention group achieved some or all of their goals. Conclusions: This small-scale pilot intervention with functional examinations and lifestyle counselling showed positive tendencies for change in short-term physical activity level. It seemed to lead to better understanding of personal functional capacity and increased motivation for lifestyle changes. Setting and fulfilling meaningful goals for lifestyle-related changes seemed to influence levels on the functional profile in positive directions. Research on larger and more diverse populations will be necessary to better understand the implications of the intervention. Trial registration: ClinicalTrials.gov: NCT05535296 first posted on 10/09/2022. [ABSTRACT FROM AUTHOR]

With the increasing prevalence of cybercrime victimization there is a growing need for prevention. Previous studies have attempted to uncover risk factors associated with cybercrime victimization in the areas of personal characteristics and online routine activities. This article aims to take the field a step further by including actual self-protective online behavior, obtained through a population-based survey experiment (N = 1886), as a risk factor for cybercrime victimization. In wave 1 of our longitudinal design, personal characteristics, online routine activities, and actual self-protective online behavior concerning password strength, clicking behavior, sharing personal information, and handling phishing emails were measured. In wave 2, cybercrime victimization of several types of cyber-enabled and cyber-dependent cybercrimes was measured one year later. Results indicate that few personal characteristics, online routine activities, and self-protective online behaviors are related to the odds of becoming a cybercrime victim. This furthermore illustrates the heterogeneity of cybercrime victimization, since most significant factors only seem to be related to the risk of one particular type of cybercrime. These results indicate that to explain cybercrime victimization, the research field needs to shift its focus and adapt to new online developments. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Animal Production & Processing Technology / JurnalIlmu Produksi dan Teknologi Hasil Peternakan is the property of IPB University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The subject of research in this paper is the investor’s risk profile as a characteristic of his behavior in the stock market. The purpose of the study is to assess the investor’s risk profile in the form of a risk ratio in a model with a linear convolution of expected return and variance. A financial consultant can use this information to create a portfolio offinancial instruments that corresponds with an investor’s acceptance of risk. This makes the study relevant because it addresses the problem of minimizing potential risks in the management of an investment portfolio, which is related to the investor’s attitude toward risk. The scientific novelty lies in the development of a mathematical approach to solving the problem of determining the risk profile based on the relationship between the solutions of two problems of choosing an investment portfolio, expressed as conditions on the parameters under which the solutions of these problems exist and coincide. Wherein, mathematical programming methods were used, as well as the Python programming language. As a result, the risk coefficient is expressed in terms of the model parameter with a constraint on profitability; a classification of the risk profile according to the acceptable value of the risk coefficient is proposed; the method is implemented as a set of programs and demonstrated on the example of the Russian stock market. The conclusion is made about the possibilities of trust managers using this approach when making decisions on choosing the best portfolio.

Background: Beneath the surface of the acute ST-elevation myocardial infarction (STEMI) iceberg lies a hidden peril, obscured by the well-known cardiovascular risk factors that tip the iceberg. Before delving into the potential time bomb these risk factors represent, it is crucial to recognize the obscured danger lurking under the surface. What secrets does the STEMI iceberg hold? To unveil these mysteries, a closer look at the pathophysiology of STEMI is imperative. Inflammation, the catalyst of the STEMI cascade, sets off a chain reaction within the cardiovascular system. Surprisingly, the intricate interplay between red blood cells (RBC) and lymphocytes remains largely unexplored in previous research. Materials and methods: The study encompassed 163 patients diagnosed with STEMI. Utilizing linear and logistic regression, the lymphocyte-to-red blood cell ratio (LRR) was scrutinized as a potential predictive biomarker. Results: There was a statistically significant correlation between LRR and the prognosis of STEMI patients. Building upon this discovery, an innovative scoring system was proposed that integrates LRR as a crucial parameter. Conclusions: Uncovering novel predictive markers for both immediate and delayed complications in STEMI is paramount. These markers have the potential to revolutionize treatment strategies by tailoring them to individual risk profiles, ultimately enhancing patient outcomes. [ABSTRACT FROM AUTHOR]

This article develops a theoretical framework on the propensity for risk applied to litigation. From this theoretical framework, it follows that the risk prone will initiate legal proceedings more than those averse to it; that when the risk prone are sued, their propensity to risk does not decrease in the face of low variability chance of loss in comparison with previous chances of loss of greater variability; and that furthermore, they generate greater legal expenses than people of other risk profiles. The aforementioned causes greater social losses on increasing the negative externalities of litigation due to the greater divergence between its private and social benefits. The latter shall be examined regarding the issues of permanent courts and the possibility of reaching agreements. [ABSTRACT FROM AUTHOR]

Long-term forensic psychiatric care and its population form a specific group within the forensic psychiatric field. The treatment goals, characteristics, and needs of this group are different from those of the wider forensic population. The focus of treatment for this group changes from risk reduction to quality of life and managing risk in the current context. In Belgium, forensic psychiatric care started slowly. This has resulted in a late onset of long-term forensic care. Consequently, there is a potentially large group of long-term forensic patients. The population of the long-stay unit in Flanders, Belgium, is described in this study. Clinical data of forensic long-stay patients were collected. The result was a description of the population in terms of risk profile and sociodemographic data. Compared to other studies, the results show an older population with more sexual offences and mostly a medium/high risk profile. Our findings suggest that the long-stay forensic population has specific challenges that require specific responses in the form of adapted care. [ABSTRACT FROM AUTHOR]

BackgroundThere is a difference in the incidence of spontaneous subarachnoid hemorrhage (SAH) between sexes, with the majority of cases occurring in female patients. Although this phenomenon has been studied from a medical perspective, the reasons for the predominance of female cases are still unclear. Non-medical factors, such as a patient’s socioeconomic situation, can differ between female and male patients, with health implications. The aim of the study was to identify socioeconomic profiles for both sexes that may be vulnerable to developing SAH. This information could potentially be used for active preventive health efforts.MethodsThis study was based on a 7-year consecutive cohort of 890 patients with SAH treated at Uppsala University Hospital, along with a sex- and age-matched 5:1 control group from Statistics Sweden. The collected information included demographic data, income that was analyzed through “earnings” (EAs), which is defined as the sum of income and other economic compensations related to work, and “disposable income” (DI), which is the net amount that an individual can use. Pension and sickness-related absence from work were measured using early pension (EP), old age pension (OAP), sickness absence (SA), and disability pension (DP). Univariate and multivariate analyses were used.ResultsAmong the women, the socioeconomic risk profile for SAH included lower education, unemployment, being registered as living single, residing in a sparsely populated municipality, and increased age. For the men, the risk profile included residing in a sparsely populated municipality and changes in civil status. Both women and men with SAH had lower EAs and DI compared to the controls. Notably, a significantly higher proportion of the women with SAH received DP compared to the controls.ConclusionResiding in a sparsely populated area was associated with an increased risk for SAH for both women and men. The women with SAH were more economically vulnerable, whereas the men faced a different type of vulnerability related to changes in civil status. We suggest that healthcare organizations use this information to identify individuals at risk and actively implement preventive measures according to stroke guidelines for both groups.

Abstract Background The enormous effect of lifestyle-related disorders on health of the global population warrants the development of preventive interventions. Focusing on musculoskeletal health and physical activity may be a way to encourage necessary lifestyle changes by making them more concrete and understandable. The aims of the current study were to develop a function-based preventive intervention aimed at lifestyle-related disorders in physically inactive 40-year-old people and to investigate the feasibility of the intervention. The feasibility study aimed to solve practical and logistical challenges and to develop the intervention based on the experiences of participants and involved clinical personnel according to defined criteria. Methods Development of the standardised functional examination was based on literature-validated tests and clinical reasoning. Development of a risk profile was based on the functional examination and similar profiles which have already proved feasible. The feasibility of the functional examination and risk profile, together with function-based lifestyle counselling was tested on 27 participants in a pilot study with two physiotherapist examinations over a four-month period. Practical results and feedback from participants and collaborating personnel were examined. Results The functional examination consists of 20 established tests not requiring specialised equipment or training which were deemed relevant for a middle-aged population and a sub-maximal ergometer test. The risk profile consists of seven functional dimensions: cardiovascular fitness, strength in upper extremity, lower extremity and trunk, mobility, balance and posture, and three non-functional dimensions: weight, self-assessed physical activity and pain. Each dimension contains at least two measures. The participants appreciated the intervention and found it motivating for making lifestyle changes. They found the tests and risk profile understandable and could see them as tools to help achieve concrete goals. The examination required 60–75 min for one physiotherapist. The recruitment rate was low and recruited participants were highly motivated to making lifestyle changes. Conclusion This project developed a functional test battery and risk profile aimed at inactive 40-year-olds which fulfilled our feasibility criteria. Functional screening and lifestyle counselling were found to be of value to a sub-group of inactive 40-year-olds who were already motivated to improve their health situations. Trial registration ClinicalTrials.gov: NCT05535296 first posted on 10/09/2022.

Introduction: The pathophysiology of chronic subdural hematoma (CSDH) remains to be fully understood. Basic knowledge of the composition and features of cells in the CSDH fluid may contribute to the understanding of the seemingly complex processes involved in CSDH formation and recurrence. This study is the first to examine the composition of cells and of cellular features in both systemic blood and subdural fluid from CSDH patients. We hypothesized that the cellular composition and features in the hematoma fluid may be; 1) different from that in the systemic blood; 2) different between patients with and without recurrence; 3) and different between the first and second operation in patients with recurrent CSDH. Methods: Systemic blood and subdural hematoma fluid were collected from CSDH patients with and without recurrent CSDH at the time of primary and secondary surgery. Analyses of cells and cellular features included total number of white blood cells, erythroblasts, reticulocytes, platelets, neutrophilocytes, lymphocytes, monocytes, eosinophils, basophils, reticulocytes, immature granulocytes, mean corpuscular cell volume (MCV), mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, hemoglobin and hematocrit. Results: Of the 85 included patients, 20 patients were operated for a recurrent CSDH within 90 days follow-up. All cells found in the systemic blood were present in the CSDH fluid, but the composition was different (p < 0.0001). MCV was higher in the hematoma fluid from the primary operation of patients later developing a recurrent CSDH compared to patients not developing recurrence (p = 0.009). Also, the percentage distribution of inflammatory cells in hematoma fluid from patients with recurrent CSDH was different between the first and second operation (p = 0.0017). Conclusion: This study is the first to investigate the cellular composition of CSDH fluid. Compared to systemic blood and to a reference distribution, an increased number of immune cells were present in the hematoma fluid, supporting an inflammatory component of the CSDH pathophysiology. MCV was higher in the subdural fluid at time of the first operation of CSDH patients later developing recurrence. Clinical trial registration: The study was approved by the Scientific Ethical Committee of the Capital Region of Denmark (Journal no. H-20051073. [ABSTRACT FROM AUTHOR]

This paper analyzes the soundness of government-owned Islamic banks before and after a merger. The research variables consist of Risk Profile as measured by Non-Performing Financing (NPF) and Financing to Deposit Ratio (FDR), Good Corporate Governance as measured by Net Open Position (NOP), Earnings as measured by Return on Assets (ROA), Return on Equity (ROE)) and Operational Efficiency Ratio (OER), and Capital as measured by the Capital Adequacy Ratio (CAR). Three government-owned Islamic banks before merger, namely Bank Rakyat Indonesia (BRI) Sharia, Bank Negara Indonesia (BNI) Sharia, Bank Sharia Mandiri (BSM) and one bank after merger namely Bank Sharia Indonesia (BSI) were selected as research objects. The study uses secondary data for the first quarter of 2019 to the third quarter of 2022. The hypothesis was tested with the Paired Sample T-Test and the Wilcoxon Signed Rank Test. The results show that the ratios of NPF, NOP, ROA, ROE, and OER have significant differences before and after the merger. Meanwhile, the ratios of FDR and CAR have no significant difference before and after the merger. This condition indicates that the ability of Islamic banks to manage FDR and CAR is quite good and remain in the soundness category before and after the merger. This study concludes that some of the soundness ratios of government-owned sharia banks are better after the merger. However, there are two ratios that are not significantly different either before or after the merger. The implication of this research is that the ability of the manager of a government-owned Islamic bank in managing the soundness of a bank greatly determines the sustainability of an Islamic bank. For further research, it is suggested to add the timeframe of the research. [ABSTRACT FROM AUTHOR]

Background: The enormous effect of lifestyle-related disorders on health of the global population warrants the development of preventive interventions. Focusing on musculoskeletal health and physical activity may be a way to encourage necessary lifestyle changes by making them more concrete and understandable. The aims of the current study were to develop a function-based preventive intervention aimed at lifestyle-related disorders in physically inactive 40-year-old people and to investigate the feasibility of the intervention. The feasibility study aimed to solve practical and logistical challenges and to develop the intervention based on the experiences of participants and involved clinical personnel according to defined criteria. Methods: Development of the standardised functional examination was based on literature-validated tests and clinical reasoning. Development of a risk profile was based on the functional examination and similar profiles which have already proved feasible. The feasibility of the functional examination and risk profile, together with function-based lifestyle counselling was tested on 27 participants in a pilot study with two physiotherapist examinations over a four-month period. Practical results and feedback from participants and collaborating personnel were examined. Results: The functional examination consists of 20 established tests not requiring specialised equipment or training which were deemed relevant for a middle-aged population and a sub-maximal ergometer test. The risk profile consists of seven functional dimensions: cardiovascular fitness, strength in upper extremity, lower extremity and trunk, mobility, balance and posture, and three non-functional dimensions: weight, self-assessed physical activity and pain. Each dimension contains at least two measures. The participants appreciated the intervention and found it motivating for making lifestyle changes. They found the tests and risk profile understandable and could see them as tools to help achieve concrete goals. The examination required 60-75 min for one physiotherapist. The recruitment rate was low and recruited participants were highly motivated to making lifestyle changes. Conclusion: This project developed a functional test battery and risk profile aimed at inactive 40-year-olds which fulfilled our feasibility criteria. Functional screening and lifestyle counselling were found to be of value to a sub-group of inactive 40-year-olds who were already motivated to improve their health situations. [ABSTRACT FROM AUTHOR]

Introduction: Suboptimal cardiovascular health is associated with adverse pregnancy outcomes and long-term cardiovascular risk. The authors examined trends in cardiovascular risk factors and correlates of suboptimal cardiovascular risk profiles among reproductive-aged U.S. women. Methods: With data from 335,959 women in the Behavioral Risk Factor Surveillance System (2015–2020), the authors conducted serial cross-sectional analysis among nonpregnant reproductive-aged women (18–44 years) without cardiovascular disease who self-reported information on 8 cardiovascular risk factors selected on the basis of Life's Essential 8 metrics. The authors estimated the prevalence of each risk factor and suboptimal cardiovascular risk profile (≥2 risk factors) and examined trends overall and by age and race/ethnicity. Using multivariable Poisson regression, the authors assessed the sociodemographic correlates of suboptimal cardiovascular risk profile. Results: The weighted prevalence of women aged

The relevance of this study arises from products being fixed as an independent object for state sanitary-epidemiological control in law. The contemporary stage of the public regulation involves the following: administrative pressure on economic entities ought to be easer but the best possible protection of citizens’ life and health should be provided. In this study, our aim was to test approaches to developing the risk-based model for control of food products on the consumer market in the country. The study relied on using the fundamental methodical approaches to the risk-based control model used by the Sanitary Service of Russia. A potential health risk was determined as a combination of likely violations of legal requirements to a certain product, severity of health outcomes due to such violations, and coefficients that described a scale of undesirable consequences. Food products were assigned into one of the following categories as per health risks: objects of extremely high risk, high risk, considerable risk, moderate risk, medium risk, or low risk. We suggest a fundamental scheme describing how to organize risk-based control of food products as an independent control object. It includes several basic elements, namely, creating a register of consumer food products; identifying priority groups of food products as per risk criteria at the federal level; identifying regional priorities. We provide substantiation for advisability of profound risk assessment performed for food products in each group considering specific frequency of sanitary violations, scales in which a certain food product in consumed in different regions, and priority consumer demands. Our suggestion is to integrate risk profiles of products and risk-based laboratory support for control into the general model. We’d like to highlight the relevance of creating a unified database to keep the results of all the control and surveillance activities including data obtained by laboratory tests of products bound to manufacturers, distributors, and sellers. It is also quite relevant to include algorithms and mathematical methods of science-intensive analysis of the data sets into software modules of the Rospotrebnadzor’s Unified Information System.

This study aims to provide empirical evidence of millennials' investment behaviors, considering their risk profiles as a moderating factor. It also explores the financial literacy and behaviors of millennials. Predictions from the Central Bureau of Statistics (Badan Pusat Statistik/BPS) suggest that millennials will form the majority in Indonesia's demographic structure, thereby shaping the country's future. The study involved 168 millennials, recruited through convenience sampling, with data collection occurring in June-July 2021. The data was analyzed using exploratory factor analysis and a structural equation model, revealing that financial literacy and behavior significantly and positively impact investing; however, while risk profile moderation affects financial literacy, it does not moderate financial behavior. The study faced limitations, including a sample size of 168 respondents—barely meeting the minimum requirements for SEM analysis—and the geographic limitation of respondents being from Palembang city. Future studies are recommended to explore a broader region with a larger sample size to enhance understanding of the moderating effect of risk profiles in financial planning.

Orientation: Investors are overwhelmed with Collective Investment Schemes (CIS) portfolio options. Research purpose: The study set out to assess the emerging themes considered essential and prevalent in establishing a risk profile, establishing a framework for risk assessment tools, and evaluating existing risk assessment tools used in the industry. Motivation for the study: In 2020, newly amended legislation confirmed the importance of a risk assessment. This legislation made it mandatory and compulsory for financial planners to conduct a risk profile analysis concerning investment products in South Africa. Consequently, CIS have implemented various risk assessment tools to establish the investor risk profile. Research approach/design and method: Documentary research methodology was employed, where secondary data were analysed qualitatively. Twelve risk assessment tools were collected, and the established framework was used to evaluate existing risk assessment tools. Main findings: A sound theoretical framework for risk assessment tools, which is comprehensive in nature and include demographic factors, risk categorisation, and regulatory factors, was established. The results indicate that current tools used in the industry are inconsistent and do not address all the factors required to establish an investor risk profile. Practical/managerial implications: The study is significant in that it guides the financial services industry into the elements of assessment in establishing an investor risk profile. Contribution/value-add: A risk profile analysis is compulsory for financial planning. Financial planners and policymakers can consider the established framework to implement a standardised, comprehensive, holistic, risk assessment tool.

Data on epidemiology trends of paediatric tuberculosis (TB) are limited in China. So, we investigated the clinical and epidemiological profiles in diagnosed TB disease and TB infection patients at Beijing Children's Hospital. Of 3 193 patients, 51.05% had pulmonary TB (PTB) and 15.16% had extrapulmonary TB (EPTB). The most frequent forms of EPTB were TB meningitis (39.05%), pleural TB (29.75%), and disseminated TB (10.33%). PTB patients were significantly younger and associated with higher hospitalization frequency. Children aged 1–4 years exhibited higher risk of PTB and TB meningitis, and children aged 5–12 years had higher risk of EPTB. The proportion of PTB patients increased slightly from 40.9% in 2012 to 65% in 2019, and then decreased to 17.8% in 2021. The percentage of EPTB cases decreased from 18.3% in 2012 to 15.2% in 2019, but increased to 16.4% in 2021. Among EPTB cases, the largest increase was seen in TB meningitis. In conclusion, female and young children had higher risk of PTB in children. TB meningitis was the most frequent forms of EPTB among children, and young children were at high risk of TB meningitis. The distribution of different types of EPTB differed by age. [ABSTRACT FROM AUTHOR]

Background and Aims Atrial fibrillation (AF) is the most common sustained arrhythmia in adults. Investigations of risk factor profiles for AF according to age and genetic risk groups are essential to promote individualized strategies for the prevention and control of AF. Methods A total of 409 661 participants (mean age, 56 years; 46% men) free of AF at baseline and with complete information about risk factors were included from the UK Biobank cohort. The hazard ratios and population-attributable risk (PAR) percentages of incident AF associated with 23 risk factors were examined, including 3 social factors, 7 health behaviours, 6 cardiometabolic factors, 6 clinical comorbidities, and the genetic risk score (GRS), across 3 age groups (40–49, 50–59, and 60–69 years) and 3 genetic risk groups (low, moderate, and high GRS). Results After a follow-up of 5 027 587 person-years, 23 847 participants developed AF. Most cardiometabolic factors and clinical comorbidities showed a significant interaction with age, whereby the associations were generally strengthened in younger groups (P interaction <.002). However, only low LDL cholesterol, renal dysfunction, and cardiovascular disease showed a significant interaction with genetic risk, and the associations with these factors were stronger in lower genetic risk groups (P interaction <.002). Cardiometabolic factors consistently accounted for the largest number of incident AF cases across all age groups (PAR: 36.2%–38.9%) and genetic risk groups (34.0%–41.9%), with hypertension and overweight/obesity being the two leading modifiable factors. Health behaviours (PAR: 11.5% vs. 8.7%) and genetic risk factors (19.1% vs. 14.3%) contributed to more AF cases in the 40–49 years group than in the 60–69 years group, while the contribution of clinical comorbidities remained relatively stable across different age groups. The AF risk attributable to overall cardiometabolic factors (PAR: 41.9% in the low genetic risk group and 34.0% in the high genetic risk group) and clinical comorbidities (24.7% and 15.9%) decreased with increasing genetic risk. The impact of social factors on AF was relatively low across the groups by age and genetic risk. Conclusions This study provided comprehensive information about age- and genetic predisposition-related risk factor profiles for AF in a cohort of UK adults. Prioritizing risk factors according to age and genetic risk stratifications may help to achieve precise and efficient prevention of AF. [ABSTRACT FROM AUTHOR]

Carbon risk has generated significant adverse impacts on firms, investors and other stakeholders. Carbon disclosure may provide market participants with information to effectively manage risks and explore opportunities. We conduct a critical review of the growing literature in these fields and seek to examine the financial effects of carbon risk and carbon disclosure. A total of 78 papers, published in influential accounting, finance, business, economics and management journals between 2011 and 2021, are reviewed. We categorise the financial effects into four groups: financial performance, valuation relevance, cost of capital and risk profiles (measures). The proxies for carbon risk and carbon disclosure are summarised. This review demonstrates inconclusive relationships between carbon risk (carbon disclosure) and firms' financial measures. These inconclusive findings may result from different carbon risk (carbon disclosure) measures, financial performance measures, sample geographies, sizes and periods, and model specifications. This review further identifies and highlights future research opportunities in relevant areas and calls for more research work to understand the influence of climate change on firms' value and activities. [ABSTRACT FROM AUTHOR]

Many bioaccumulative and toxic contaminants are known to co-occur in fish tissue, yet this covariance has not been explicitly incorporated into model-based risk assessments that inform fish consumption advisories. We utilize available U.S. EPA datasets to statistically model the covariance among contaminant concentrations in fish tissue and the dependence of this covariance on waterbody and watershed conditions. We find that most contaminants positively covary, whether fish were collected in rivers, lakes, or coastal waters. Mercury in lakes and mercury, PFCs, and heptachlor in rivers covary negatively with the other contaminants. While much of the variance and covariance in contaminants can be statistically related to fish characteristics and watershed and waterbody conditions, a large amount remains in model residuals. This implies that single contaminant models, even if highly precise, can misestimate total health risk by neglecting the substantial covariance with other contaminants that is left unmodelled. [ABSTRACT FROM AUTHOR]

The purpose of this study is to analyze the effect of risk profile variables both on the fulfillment of core capital adequacy and to find out which risk variables have a dominant influence on core capital adequacy in bank books 1 and 2. This research is included in quantitative analysis. This study uses purposive sampling, and data collection is carried out using the documentation method by looking at the annual financial reports on the OJK (Financial Services Authority) website, BI (Bank Indonesia) website, and the Bank's website object of research. The results of this study using the level of capital ratios by banks, namely the ratio of CAR, ROA, OEOI, NIM, LDR, and RAR, show good results. Because the standard deviation reflects very high variations, the distribution of data shows expected results and does not cause bias. Assessment of the Bank's Soundness Level using a risk approach (Risk-based Bank Rating) is executed based on a thorough analysis of the Bank's performance, risk profile, problems, and development prospects of the Bank since the purpose of maintaining the soundness of banks through consideration of the aspect of capital adequacy is the most significant part in order to gain public trust.

Context: There is no evidence regarding the effect of the FIFA 11+ on landing kinematics in male soccer players, and few studies exist regarding the evaluating progress of interventions based on the initial biomechanical profile. Objective: To investigate the effect of the FIFA 11+ program on landing patterns in soccer players classified as at low or high risk for noncontact anterior cruciate ligament injuries. Design: Randomized controlled trial. Setting: Field-based functional movement screening performed at the soccer field. Participants: A total of 24 elite male youth soccer players participated in this study. Intervention: The intervention group performed the FIFA 11+ program 3 times per week for 8 weeks, whereas the control group performed their regular warm-up program. Main Outcome Measures: Before and after the intervention, all participants were assessed for landing mechanics using the Landing Error Scoring System. Pretraining Landing Error Scoring System scores were used to determine risk groups. Results: The FIFA 11+ group had greater improvement than the control group in terms of improving the landing pattern; there was a significant intergroup difference (F1,20 = 28.86, P <.001, η p 2 =.591). Soccer players categorized as being at high risk displayed greater improvement from the FIFA 11+ program than those at low risk (P =.03). However, there was no significant difference in the proportion of risk category following the routine warm-up program (P = 1.000). Conclusions: The present study provides evidence of the usefulness of the FIFA 11+ program for reducing risk factors associated with noncontact anterior cruciate ligament injuries. The authors' results also suggest that soccer players with the higher risk profile would benefit more than those with lower risk profiles and that targeting them may improve the efficacy of the FIFA 11+ program. [ABSTRACT FROM AUTHOR]

Background Chronic kidney disease (CKD) is common but heterogenous and is associated with multiple adverse outcomes. The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD cohort was established to investigate risk factors for clinically important outcomes in persons with CKD referred to secondary care. Methods Eligible participants with CKD stages G3–4 or stages G1–2 plus albuminuria >30 mg/mmol were enrolled from 16 nephrology centres in England, Scotland and Wales from 2017 to 2019. Baseline assessment included demographic data, routine laboratory data and research samples. Clinical outcomes are being collected over 15 years by the UK Renal Registry using established data linkage. Baseline data are presented with subgroup analysis by age, sex and estimated glomerular filtration rate (eGFR). Results A total of 2996 participants was enrolled. Median (interquartile range) age was 66 (54–74) years, eGFR 33.8 (24.0–46.6) mL/min/1.73 m2 and urine albumin to creatinine ratio 209 (33–926) mg/g; 58.5% were male. Of these participants, 1883 (69.1%) were in high-risk CKD categories. Primary renal diagnosis was CKD of unknown cause in 32.3%, glomerular disease in 23.4% and diabetic kidney disease in 11.5%. Older participants and those with lower eGFR had higher systolic blood pressure and were less likely to be treated with renin–angiotensin system inhibitors (RASi) but were more likely to receive a statin. Female participants were less likely to receive a RASi or statin. Conclusions NURTuRE-CKD is a prospective cohort of persons who are at relatively high risk of adverse outcomes. Long-term follow-up and a large biorepository create opportunities for research to improve risk prediction and to investigate underlying mechanisms to inform new treatment development. [ABSTRACT FROM AUTHOR]

Objective: To determine if two pre‐race screening tools (abbreviated tool of two open‐ended pre‐race medical screening questions [ABBR] vs. a full pre‐race medical screening tool [FULL]) identify running race entrants at higher risk for medical encounters (MEs) on race day. Methods: 5771 consenting race entrants completed both an ABBR and a FULL pre‐race screening questionnaire for the 2018 Comrades Marathon (90 km). ABBR tool questions were (1) allergies, and (2) known medical conditions and/or prescription medication use. The FULL tool included multiple domains of questions for chronic diseases including cardiovascular disease (CVD), symptoms, risk factors, allergies and medication use. ABBR responses were manually coded and compared to the FULL tool. The prevalence (%: 95%CI), and the test for equality of prevalence of entrants identified by the ABBR vs. FULL tool is reported. Results: The ABBR identified fewer entrants with allergies (ABBR = 7.9%; FULL = 10.4%: p = 0.0001) and medical conditions/medication use (ABBR = 8.9%; FULL = 27.4%: p = 0.0001). The ABBR tool significantly under‐reported entrants with history of cardiovascular disease (CVD), CVD risk factors, other chronic diseases and prescription medication vs. the FULL tool (p = 0.0001). The ABBR tool identified fewer entrants in the "high" (ABBR = 3.4%; FULL = 12.4%) and "very high" risk (ABBR = 0.5%; FULL = 3.4%) categories for race day MEs (p = 0.0001). Conclusions: An abbreviated pre‐race screening tool significantly under‐estimates chronic medical conditions, allergies, and race entrants at higher risk for MEs on race day, compared with a full comprehensive screening tool. We recommend that a full pre‐race medical screening tool be used to identify race entrants at risk for MEs. [ABSTRACT FROM AUTHOR]

Background: Eustachian tube balloon dilation (ETBD) has been Food and Drug Administration (FDA) approved for refractory Eustachian tube dysfunction since 2016. While ETBD is generally seen as safe, the complication profile has not been well defined. Objective: The objective of this study was to utilize the FDA manufacturer and user facility device experience (MAUDE) database to better assess adverse events (AE) related to ETBD. Methods: This is a study of a multiinstitutional database maintained by the U.S. FDA. A database analysis was performed via the collaboration of multiple clinicians at tertiary referral centers. The FDA MAUDE database was queried for all medical device reports (MDR) related to ETBD devices from January 2012 to November 2022. Eighty-eight unique MDR were identified, 16 of which met inclusion criteria. Results: Three MDRs were classified as device-related (18.8%); none resulted in an AE. Thirteen MDRs (81.3%) were patient-related; all were classified as AEs. The most common AE was postoperative subcutaneous emphysema (n = 6, 46.2%). Of the patients with subcutaneous emphysema, there was a wide range of severity. The most severe AE (n = 1, 6.3%) was postoperative stroke secondary to carotid artery dissection. Conclusion: Though ETBD is generally seen as a safe procedure, there have been several concerning AEs reported to date. Increased awareness of ETBD complications can serve as a primer for improved patient education and counseling during the informed consent process and aid surgeons in clinical decision-making. Future studies with standardized reporting protocols are warranted to create a central registry for ETBD. [ABSTRACT FROM AUTHOR]

Establishing an enterprise risk management (ERM) system is widely viewed as providing firms with the tools and processes needed to build resilience and expertise, enabling them to manage the consequences of crises that have led to the collapse of major firms across different industries globally. Intended for use in advanced accounting, auditing, and finance courses, this case study (of a true event) describes the development and implementation of an ERM system for a U.S. multinational nonprofit firm during the 2015–2021 period. The case study's main learning objectives are several-fold. First, couched within the recent economic environment, it informs students on some of the more important academic and applied research on corporate risk management. Second, students will learn to analyze the content of a questionnaire designed to capture the integrated effects of the firm's risk culture, risk structure, risk governance, and control for establishing its risk profile. Third, they will learn to create and apply multi-dimensional risk indices to measure and prioritize the firm's risk exposures. Finally, the last learning outcome focuses on strategies to triangulate the firm's overall risk profile and risk prioritization results to construct mitigation strategies that build resilience and create value through risk diversification, information signaling, the exploitation of natural hedges, and enhancing the board's governing efficiency. The nonprofit nature of the firm in this case study introduces no methodological or conceptual constraints or limitations in applying the proposed risk management methodologies to for-profit or publicly traded firms. [ABSTRACT FROM AUTHOR]

A delirium can be encountered in almost all hospital sectors. The prevalence varies between 20 and 40 % in internal medicine and surgical wards and between 50 and 60 % in palliative care and intensive care units. A delirium is characterized by impaired attention, consciousness, and cognitive impairment with acute onset and fluctuating course. People with delirium have inferior clinical outcomes, including higher mortality and more need for long-term care after discharge. This article first reviews the clinical and pathophysiologic basis of delirium, followed by a detailed description of individual risk profiles based on a prospective, hospital-wide cohort study (Delir-Path) conducted at the University Hospital Zurich. We will then give a brief update on diagnosis and management of delirium and an outlook on how neurophysiology and blood biomarkers can complement delirium care in the future. [ABSTRACT FROM AUTHOR]

Objective To explore; th(i preeliertive; value; of machine learning methods for hyperlipidemia in the e;lele;rly, and analyze; the; risk factors for hyperlipidemia in the; clelcrly. Methods The; stratified random edustcr sampling meitheiel was uscel te» se;le;e;t 5 759 edelcrly people; aged 60 anel above; in 27 communities in 9 e'ountics anel municipalities of Weifang City, anel the; health examination data of these; edelcrly people; in 2020 was collected. Missing or unusual data were; excluelcel, anel 4 534 edeler adults were; eventually inedueicel in the; stuely. Ten important risk factors we;re; scree;ne;el out by univariate; analysis, which was used to construct support vce;tor machines, decision trees, XGBoost, CATBoost anel LightGBM risk preeliertion moeleds, anel AUG (Area unelcr ROC curve), accuracy, accuraeiy, recall, anel Fl value; were; uscel te) evaluate; its performance. Results The; comprehensive; performance; e»f the; CATBoost machine; learning rnoele;! was the; best anel its AUC, precision, accuraey, recall anel Fl values were; 0. 82, 76. 49%, 92. 46%, 78. 68%, anel 0. 85, respectively. In the; process of CATBoost rnoele;! prediesting the; risk e»f hypcrlipielcmia in the; edelcrly, nine; variables were; more; important for the; pre;elie;tion e»f hyperlipidemia risk, anel their importance; was in the; orde;r of high te; bottom; systedie; blooel pressure;, waist circumference, fasting blooel glucose, boely mass inelex, diastolic blooel pressure;, smoking, age;, alcohol consumptiem, anel gender. Moreover, after rnoele;! optimization, it was found that only including these; nine; factors coulel be;tte;r pre;elie;t risks. Conclusion The; risk preeliertion mode;! of hypcrlipielcmia in the; clelcrly based on the; CATBoost machine; learning me;thod has a gejeiel prediction e;ffe;ct, which can provide; a reference; for the; pre;ve;ntie)n anel treatment of hypcrlipielcmia in the; clelcrly. [ABSTRACT FROM AUTHOR]

The extended-spectrum β-lactamase (ESBL)-producing Enterobacterales (ESBL-EB) encompass several important human pathogens and are found on the World Health Organization (WHO) priority pathogens list of antibiotic-resistant bacteria. They are a group of organisms which demonstrate resistance to third-generation cephalosporins (3GC) and their presence has been documented worldwide, including in aquaculture and the aquatic environment. This risk profile was developed following the Codex Guidelines for Risk Analysis of Foodborne Antimicrobial Resistance with the objectives of describing the current state of knowledge of ESBL-EB in relation to retail shrimp and salmon available to consumers in Canada, the primary aquacultured species consumed in Canada. The risk profile found that Enterobacterales and ESBL-EB have been found in multiple aquatic environments, as well as multiple host species and production levels. Although the information available did not permit the conclusion as to whether there is a human health risk related to ESBLs in Enterobacterales in salmon and shrimp available for consumption by Canadians, ESBL-EB in imported seafood available at the retail level in Canada have been found. Surveillance activities to detect ESBL-EB in seafood are needed; salmon and shrimp could be used in initial surveillance activities, representing domestic and imported products. [ABSTRACT FROM AUTHOR]

Based on the observations, the background of this study is that there are several financial ratios that experience fluctuations and contrary the theory and to find out level of bank health in Panin Dubai Syariah Bank period 2017-2021. This study aims to find out the health level of Panin Dubai Syariah Bank for the period 2017-2021 using the RGEC method. The valuation factors used are Risk Profile, Good Corporate Governance, Earning and Capital factors. The object of this research is the financial statements of research used is quantitative with a descriptive approach. The type of data used in this study is secondary data. The results showed that the health level of Panin Dubai Syariah Bank based on Risk Profile factors gets a healthy predicate, Good Corporate Governance gets a healthy predicate, Earning gets an unhealthy predicate and Capital gets a very healthy predicate.

Abstract Cuprotosis is a novel and unique form of cell death that is of great value in a variety of cancers. However, the prognostic role of cuprotosis-related genes (CRGs) in lung cancer remains undetermined. We compared the expression profile of CRGs in lung adenocarcinoma (LUAD) patients, revealing the genetic alterations and inter-gene correlations of CRGs. Based on 13 CRGs, LUAD patients could be well differentiated into two molecular subgroups, and the differentially expressed genes (DEGs) in these molecular subtypes were identified. Furthermore, 10 cuprotosis pattern-related DEGs with a significant prognostic value were obtained for constructing a prognostic model. Through validation in an external validation set, the prognostic model based on the CRGs-risk score showed the robust and effective predictive ability and served as an independent prognostic indicator for LUAD patients. Therefore, combining the CRGs-risk score with multiple factors such as clinicopathological characteristics, a quantitative nomogram was developed to predict the survival and prognosis of LUAD patients, improving the clinical application value of the CRGs-risk score. In the low CRGs-risk score group, the related immune cell infiltration was increased and the immune function was activated in LUAD patients. This study may add to the knowledge of CRGs in LUAD, partly contribute to evaluating the prognosis of LUAD patients, and provide direction for the development of targeted therapy and immunotherapy.

Background: Renal hyperparathyroidism results from pathophysiologic changes induced and maintained by terminal renal failure. Surgical treatment is possible using various resection strategies. Aim of the work (research question): The aim of this work is to illustrate the indications, techniques and resection strategies for surgical treatment of renal hyperparathyroidism. Material and methods: National and international guidelines regarding the surgical treatment of renal hyperparathyroidism were analyzed. Furthermore, our own practical experience was integrated into the article. Results: While the indications for surgery according to the Surgical Working Group Endocrinology (CAEK) guidelines are given in cases of clinical impairment and renal hyperparathyroidism that cannot be controlled by medication, international guidelines additionally refer to the absolute parathyroid hormone level for deciding for surgery. Discussion: Individual patient consultation is necessary in the case of renal hyperparathyroidism in order to determine the right time for surgical treatment as well as the most suitable surgical technique, taking into account the individual risk profile and other therapeutic perspectives, including renal transplantation. [ABSTRACT FROM AUTHOR]

Introduction: Understanding the specific risk profile for distinct forms of dating aggression (DA) is very informative to define cross-cutting interventions. The study aims to evaluate whether specific profiles of risk defined using a person-oriented approach predicted physical, sexual, and psychological DA after 6 months. Methods: Eight hundred sixty-six Spanish adolescents were interviewed at two time points (50.5% male; average age = 15.04). Latent profile analysis at T1 was used to delineate profiles of individual and relational risk. Results: A three-class model best represents the data: a "normative" class (N = 768; 88%); a "highly aggressive" class characterized by acceptance of violent norms, bullying behaviors, and anger dysregulation (N = 13, 1.5%); a "jealous-conflictual" class characterized by cognitive and emotional jealousy, negative couple quality, and anger dysregulation (N = 85, 10%). Controlling for age, sex, and longitudinal stability, physical DA was predicted significantly by the "highly aggressive" profile (β =.11; p <.05), psychological DA by the "jealous-conflictual" profile (β =.16; p <.01), and sexual DA by the "jealous-conflictual" (β =.20; p <.001) and "highly aggressive" profile as a trend (β =.08; p =.071). Conclusions: Specific risk profiles differentially predict risk for physical, sexual, and psychological DA perpetration. A general aggressive pattern predicts physical DA and sexual DA weakly, whereas psychological and sexual DA are associated with a couple of risks, where the dimension of jealousy, control, and conflict characterizes the dynamic between partners. Policy Implications: Findings suggested that physical DA, and at a lower level sexual DA, should be prevented using cross-cutting strategies on general aggression. Psychological and sexual DA might require more contextually based interventions. [ABSTRACT FROM AUTHOR]

Introduction: Little is known about risk factors of dementia in Latin American countries. We aimed to identify socio-demographic, health and lifestyle risk factors of incident dementia in Cuban older adults. Methods: Data were from 1,846 participants in the Cuban cohort of the 10/66 Dementia Research Group. Participants completed questionnaires, health examinations, and cognitive tests at baseline (2003-2006) and 4.5 years later (2007-2010). Associations between risk factors (baseline) and incident dementia (follow-up) were examined using logistic regression. Results: Just over 9% of participants developed dementia. Overall, older age and low physical activity were associated with incident dementia. In those 65-74 years of age, depression, stroke and low physical activity were associated with incident dementia. In those ≥75 years of age, low physical activity, never eating fish, and smoking were associated with incident dementia. Conclusions: Modifiable lifestyle factors play an important role in developing dementia in Cuban older adults. This knowledge opens up opportunities for preventive strategies.

The object of research is the risk appetite of an IT project. It is important for the implementation of an IT project to determine the critical values of indicators important for the activity, which predetermines the need to define and manage risk appetite. Risk appetite management in the implementation of an IT project directly affects its successful implementation and requires theoretical and methodological foundations for its consideration in the project management system. By establishing risk appetite, the project manager determines how much risk s/he is willing to take in order to achieve the key goals of the project. The definitions of “risk appetite”, “risk tolerance”, “risk appetite” in the implementation of IT projects have been clarified. It is determined that risk appetite should be considered as an integral set of IT project risk, which affects the achievement of the set goals: completion of the project in time, volume and budget that have been agreed. Risk tolerance defines acceptable limits for individual operational risks of the project. This will allow project participants to understand the limits of their authority and responsibility in risk management. A survey of project managers was conducted on their understanding of risk appetite and its use in project management. As a result, the most significant risks and the most used indicators and methods for establishing the risk appetite of IT projects were identified. This made it possible to generalize the experience of establishing and using risk appetite in IT projects. Also, based on the results of the study, an integrated risk appetite management system for the implementation of an IT project is proposed. This will allow balancing the permissible risk limits and the desired goals of its implementation during the implementation of the IT project. At the same time, an important place is occupied by taking into account the interests of stakeholders and their vision of the results, taking into account the risks. The findings reported here could make it possible to systematize risk management of IT projects and determine it as part of a single integrated project management process [ABSTRACT FROM AUTHOR]

Bank Indonesia Regulation No.13/1/PBI/2011 requires banks to conduct regular self-assessments using the RBBR (Risk-based Bank Rating) risk approach at both individual and consolidated levels. This health assessment is known as RGEC (Risk Profile, Good Corporate Governance, Earnings, and Capital). The aim of this research is to determine the effect of bank soundness on firm value by analyzing the relationship between Risk Profile, Good Corporate Governance, Earnings, and Capital in conventional banks listed on the Indonesian Stock Exchange from 2019 to 2021. The study used purposive sampling, selecting conventional banking companies that were registered and published complete annual financial statements and did not merge during 2019-2021. The final sample size was 40 banks that met the predetermined criteria. Data analysis was performed using Microsoft Excel 2019, and the hypothesis was tested using panel data regression analysis with the EViews version 12.0 program, with a significance level of 5%. The study results showed that (1) Risk Profile using Non-Performing Loan had no significant effect on firm value, (2) Good Corporate Governance had a positive effect on firm value, (3) Earnings using Return on Assets had no significant effect on firm value, and (4) Capital using Capital Adequacy Ratio had a positive effect on firm value. The implications of this research for banks are that to increase company value, conventional banks need to pay attention to RGEC to improve their performance, and for investors, it serves as a reflection of good information to invest. However, there are limitations to this study, such as some banking companies not publishing complete financial statements, and research variables, namely profile risk and earnings, that do not support the theory, requiring further research. [ABSTRACT FROM AUTHOR]

Household waste represents a major source of energy, nutrients, and recyclable material. In order to exploit benefits and avoid hazards in the context of circular economy, the risk profile towards human and the environment should be assessed. Here, we investigated the presence of micropollutants by quantitative target analysis, suspect and non-target screening and evaluated changes in the chemical fingerprint upon anaerobic digestion. Extracts were analyzed by reversed phase liquid chromatography high-resolution mass spectrometry (LC-HRMS) and gas chromatography mass spectrometry (GC–MS). Thirty-one of 51 target micropollutants were detected in low ng/mL levels except for few detections at µg/mL levels. The micropollutants quantified in this study included the following: pharmaceuticals (salicylic acid, amitriptyline, carbamazepine); biocides (triclocarban, 2-phenylphenol); industrial compounds used in, e.g., paper industry (pentachlorphenol, PFOS, PFOA, bisphenol A); aromatics, polycyclic aromatics, and heteroaromatics, and their alkylated, hydroxylated, or carboxylated analogues. Fifty of 206 compounds from the suspect screening list were tentatively identified. These included phthalates, methylparaben, phenol, benzophenone, and pharmaceuticals, e.g., ibuprofen. Most compounds detected by GC–MS decreased more than twofold in peak height or remained unaffected by the anaerobic digestion, and very few increased more than twofold, e.g., p-cresol, menthol, and octadecanal. From the LC-HRMS non-target screening analysis, 250 chemical components were resolved using the multiway curve resolution technique PARAFAC2; of these, carbidopa was the only identified unknown. [ABSTRACT FROM AUTHOR]

Tea is popular at home and abroad for its unique flavor and bioactive substances that are beneficial to human health. However， as a special economic crop with a long production chain， the background of microorganisms involved in the production process of tea is still unclear， and potentially harmful microorganisms and mycotoxins are present in tea. Nowadays， the investigation shows that the risk of mycotoxin exposure caused by tea drinking is very low， but the monitoring of fungi and mycotoxin contamination in tea and the source of related harmful secondary metabolites need to be solved urgently. In this paper， the research on the contamination situation， prevention and control of fungi and mycotoxin in tea is reviewed. The potential contamination risk of mycotoxin in tea is analyzed and discussed in order to provide reference for the assessment and control of mycotoxin contamination in tea and promote the establishment of good tea quality management and hygiene control systems.

Cuprotosis is a novel and unique form of cell death that is of great value in a variety of cancers. However, the prognostic role of cuprotosis-related genes (CRGs) in lung cancer remains undetermined. We compared the expression profile of CRGs in lung adenocarcinoma (LUAD) patients, revealing the genetic alterations and inter-gene correlations of CRGs. Based on 13 CRGs, LUAD patients could be well differentiated into two molecular subgroups, and the differentially expressed genes (DEGs) in these molecular subtypes were identified. Furthermore, 10 cuprotosis pattern-related DEGs with a significant prognostic value were obtained for constructing a prognostic model. Through validation in an external validation set, the prognostic model based on the CRGs-risk score showed the robust and effective predictive ability and served as an independent prognostic indicator for LUAD patients. Therefore, combining the CRGs-risk score with multiple factors such as clinicopathological characteristics, a quantitative nomogram was developed to predict the survival and prognosis of LUAD patients, improving the clinical application value of the CRGs-risk score. In the low CRGs-risk score group, the related immune cell infiltration was increased and the immune function was activated in LUAD patients. This study may add to the knowledge of CRGs in LUAD, partly contribute to evaluating the prognosis of LUAD patients, and provide direction for the development of targeted therapy and immunotherapy. [ABSTRACT FROM AUTHOR]

R&D investments in response to performance feedback have been extensively studied. We show that both firm risk profile (i.e. low vs high risk) and business strategy (i.e. Prospector vs Defender), two aspects understudied in this context, have incremental moderating effects (both separate and joint) on this R&D-performance feedback relationship. Using a sample of US listed firms from 2000 to 2019, we observe that, when performance relative to aspiration level decreases (increases), without controlling for moderating effects of risk and strategy, firms tend to increase (decrease) R&D investments. However, as risk profile changes from low to high risk, responses to performance feedback tend to change from decreasing R&D or maintaining status quo to increasing R&D investments. We also find that, in response to performance deviation from aspiration level (regardless of the direction), Defenders tend to decrease R&D investments, regardless of risk profile, whereas Prospectors tend to increase R&D investments (maintain status quo) when their performance relative to aspiration level decreases (increases). [ABSTRACT FROM AUTHOR]