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Here, a new‐rising technology (DNA storage) in which the binary digital information/data is converted into a DNA sequence composed of distinct nucleotides, providing a dense, stable, energy‐efficient, and sustainable data storage solution is studied. In principle, this technology offers substantial data density. However, the theoretical limit of DNA storage has not been achieved yet. In this study, a new DNA storage system is proposed based on hydrogels with SiO2 layer (their pore size can be regulated). The highest data density of the hydrogels is obtained to be 6.3 × 109 GB g−1. Further, by coupling them with digital polymerase chain reaction (dPCR), the recovery limit reaches five copies of DNA. Subsequently, three‐dimensional (3D) printing is used to explore the effect of macrostructures on the DNA storage capacity. Finally, bionic‐structure thermally‐responsive robust (Best) hydrogels with four different structures are developed, which achieve a data density of 1.04 × 1010 GB g−1. [ABSTRACT FROM AUTHOR]

Abstract Here, a new‐rising technology (DNA storage) in which the binary digital information/data is converted into a DNA sequence composed of distinct nucleotides, providing a dense, stable, energy‐efficient, and sustainable data storage solution is studied. In principle, this technology offers substantial data density. However, the theoretical limit of DNA storage has not been achieved yet. In this study, a new DNA storage system is proposed based on hydrogels with SiO2 layer (their pore size can be regulated). The highest data density of the hydrogels is obtained to be 6.3 × 109 GB g−1. Further, by coupling them with digital polymerase chain reaction (dPCR), the recovery limit reaches five copies of DNA. Subsequently, three‐dimensional (3D) printing is used to explore the effect of macrostructures on the DNA storage capacity. Finally, bionic‐structure thermally‐responsive robust (Best) hydrogels with four different structures are developed, which achieve a data density of 1.04 × 1010 GB g−1.