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3 results on '"rectal body temperature"'

2. Hypogonadism alters cecal and fecal microbiota in male mice

Author

Naoki Harada, Hiroshi Inui, Takeshi Izawa, Kazuki Hanada, Ryoichi Yamaji, and Ryo Hanaoka

Subjects
0301 basic medicine, Microbiology (medical), Male, medicine.medical_specialty, obesity, rectal body temperature, medicine.drug_class, Biology, Gut flora, Microbiology, metabolic syndrome, sarcopenia, 03 medical and health sciences, Cecum, chemistry.chemical_compound, Feces, Mice, fluids and secretions, Internal medicine, androgen receptor, medicine, Animals, Humans, Testosterone, stool, cecum, Bacteria, gut microbiota, Hypogonadism, Gastroenterology, type 2 diabetes mellitus (T2DM), medicine.disease, Androgen, biology.organism_classification, Obesity, Gastrointestinal Microbiome, Addendum, Androgen receptor, Mice, Inbred C57BL, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Endocrinology, Castration, chemistry, Cardiovascular Diseases, Sarcopenia, Metabolic syndrome, non-alcoholic fatty liver disease (NAFLD)
Abstract

Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Here, we show that changes in cecal microbiota (e.g., an increased Firmicutes/Bacteroidetes ratio and number of Lactobacillus species) were consistent with changes in feces and that there was a decreased cecal content secondary to castration in HFD mice. Castration increased rectal body temperature and plasma adiponectin, irrespective of diet. Changes in the gut microbiome may provide novel insight into hypogonadism-induced cardiovascular diseases.

Published
2016

3. Hypogonadism alters cecal and fecal microbiota in male mice.

Author

Harada N, Hanaoka R, Hanada K, Izawa T, Inui H, and Yamaji R

Subjects
Animals, Bacteria classification, Bacteria genetics, Cardiovascular Diseases etiology, Cardiovascular Diseases metabolism, Humans, Hypogonadism complications, Hypogonadism metabolism, Male, Mice, Mice, Inbred C57BL, Obesity etiology, Obesity metabolism, Testosterone metabolism, Bacteria isolation & purification, Cecum microbiology, Feces microbiology, Gastrointestinal Microbiome, Hypogonadism microbiology
Abstract

Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Here, we show that changes in cecal microbiota (e.g., an increased Firmicutes/Bacteroidetes ratio and number of Lactobacillus species) were consistent with changes in feces and that there was a decreased cecal content secondary to castration in HFD mice. Castration increased rectal body temperature and plasma adiponectin, irrespective of diet. Changes in the gut microbiome may provide novel insight into hypogonadism-induced cardiovascular diseases.

Published
2016
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