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ABSTRACT Ageing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endometrial organoids from young and advanced age females, to elucidate the underlying mechanisms and to explore novel treatment strategies for endometrial ageing. First, we found that age‐associated decline in endometrial functions including fibrosis and diminished receptivity, already exists in reproductive age. Subsequently, based on RNA‐seq analysis, we identified several changes in molecular processes affected by age, including fibrosis, imbalanced inflammatory status including Th1 bias in secretory phase, cellular senescence and abnormal signalling transduction in key pathways, with all processes been further validated by molecular experiments. Finally, we uncovered for the first time that PI3K‐AKT‐FOXO1 signalling pathway is overactivated in ageing endometrium and is closely correlated with fibrosis and impaired receptivity characteristics of ageing endometrium. Blocking or activation of PI3K by LY294002 or 740Y‐P could attenuate the effect of ageing or accelerate dysfunction of endometrial organoids. This discovery is expected to bring new breakthroughs for understanding the pathophysiological processes associated with endometrial ageing, as well as treatment strategies to improve reproductive outcomes in women of advanced reproductive age. [ABSTRACT FROM AUTHOR]

Police resistance to research is a major barrier to the implementation of evidence-based policing. In this study, we explored how individual, educational and organisational factors affect receptivity to research evidence among both police officers and criminology students in Taiwan. We did this via a longitudinal quasi-experimental design tracking two cohorts of police officers (n = 540) and a comparison group of criminology undergraduates (n = 43). Our findings show that individual, educational and organisational factors are all significantly related to police officer receptivity to research evidence. Comparing police officers to criminology students, we find that time spent in police education significantly reduces receptivity to research evidence. Among criminology students the reverse was true. The implications of the findings for police education and evidence-based policing in Taiwan are discussed. [ABSTRACT FROM AUTHOR]

Endometrium receptivity is a multifactor-regulated process involving progesterone receptor-regulated signaling, cytokines and chemokines, and additional growth regulatory factors. In the female reproductive system, macrophages have distinct roles in the regulation of receptivity, embryo implantation, immune tolerance, and angiogenesis or oxidative stress. In the present study, we investigated the effects of PMA-activated THP-1 macrophages on the receptivity-related genes, cytokines and chemokines, growth regulators, and oxidative stress-related molecules of HEC-1A endometrium cells. We established a non-contact co-culture in which the culture medium of the PMA-activated macrophages exhibiting the pro-inflammatory phenotype was used for the treatment of the endometrial cells. In the endometrium cells, the expression of the growth-related factors activin and bone morphogenetic protein 2, the growth hormone EGF, and the activation of the downstream signaling molecules pERK1/2 and pAkt were analyzed by ELISA and Western blot. The secretions of cytokines and chemokines, which are involved in the establishment of endometrial receptivity, and the expression of matrix metalloproteinases implicated in invasion were also determined. Based on the results, the PMA-activated THP-1 macrophages exhibiting a pro-inflammatory phenotype may play a role in the regulation of HEC-1A endometrium cells. They alter the secretion of cytokines and chemokines, as well as the protein level of MMPs of HEC-1A cells. Moreover, activated THP-1 macrophages may elevate oxidative stress protection of HEC-1A endometrium cells. All these suggest that pro-inflammatory macrophages have a special role in the regulation of receptivity-related and implantation-related factors of HEC-1A cells. [ABSTRACT FROM AUTHOR]

Intelligence-led policing (ILP) approaches seek to utilize a variety of strategies capitalizing on intelligence and analysis to reduce, address, and prevent crime or harm. Often, the application of these strategies involves a top-down approach. An exception to this is the Phoenix Police Department's patrol-driven Intelligence Officer Program (IOP). This article examines the extent to which personnel from the department are receptive to this specific patrol-driven ILP approach. More specifically, responses from surveys of patrol officers, intelligence officers, and their supervisors are used to explore the perceived value of the program to patrol activities and the patrol function more broadly. Results suggest that stakeholders seem to be enthusiastic about the IOP. Importantly, it is demonstrated that more familiarity and engagement with programs can encourage greater receptivity to policing innovations such as patrol-driven ILP programs. Potential avenues for research are also discussed. [ABSTRACT FROM AUTHOR]

In internally fertilizing species, an individual's mating history (whether they have previously participated in a successful mating interaction) can influence a range of mating behaviours. For example, mating often leads to a reduction in how responsive individuals are to future mating opportunities, especially for females. This fits the prediction of sexual selection theory that unmated individuals should be highly responsive to sexual stimuli to ensure a mating. This has led many researchers to prefer to use only unmated females in mating experiments, to maximize the likelihood that females will respond to sexual stimuli. However, other studies show contrasting results, and this effect has not yet been quantified formally. There is also some evidence that males of some species become less responsive after mating. This means it is unclear how general this behavioural change is, whether it occurs in both sexes, or whether it differs across taxonomic groups. I present a formal meta-analysis of 41 studies and 38 animal (mostly arthropod) species, which confirmed that female responsiveness to future mating opportunities is significantly reduced after mating. However, I found no consistent evidence for such an effect in males. This may be due to the greater mating potential of males compared to females, meaning that males typically benefit from further matings while females do not. I also collate evidence suggesting that most mating experiments probably exclusively use only unmated females. I use this evidence to consider how male and female mating history should influence how we design mating experiments. • Mating often leads to a reduction in how sexually responsive individuals are. • I performed a meta-analysis comparing the effect of mating on responsiveness. • Across 26 species, female responsiveness is significantly reduced after mating. • I found no consistent evidence for such an effect in males. • Researchers often prefer to use only unmated females in mating experiments. [ABSTRACT FROM AUTHOR]

Through the literary explorations and poetry of Alice Oswald, and through analysis of detailed clinical material from a Kleinian perspective, the authors expand the bounds of reverie as it is usually construed in psychoanalytic consulting rooms. The authors draw attention to the presence of a relationship to the more-than-human world as an integral aspect of our internal experience, and to the value of consideration of the quality and dynamic meaning of connections to the natural world in ordinary analytic work. The relationship to the primary object heavily influences the form taken by the relationship to the natural world, but once established, this connection has the possibility for a life of its own, that can provide a different kind of containment than the human variety, allow experimentation with new ways of being, and can strengthen the ego. The authors address the clinical implications of listening enhanced by an ear for affiliation to the natural world. [ABSTRACT FROM AUTHOR]

Handwritten tasks are better suited than digital ones to assess higher-order mathematics skills, as students can express themselves more freely. However, maintaining reliability and providing feedback can be challenging when assessing high-stakes, handwritten mathematics exams involving multiple assessors. This paper discusses a new semi-automated grading approach called 'checkbox grading'. Checkbox grading gives each assessor a list of checkboxes consisting of feedback items for each task. The assessor then ticks those feedback items which apply to the student's solution. Dependencies between the checkboxes can be set to ensure all assessors take the same route on the grading scheme. The system then automatically calculates the grade and provides atomic feedback to the student, giving a detailed insight into what went wrong and how the grade was obtained. Atomic feedback consists of a set of format requirements for mathematical feedback items, which has been shown to increase feedback's reusability. Checkbox grading was tested during the final high school mathematics exam (grade 12) organised by the Flemish Exam Commission, with 60 students and 10 assessors. This paper focuses on students' perceptions of the received checkbox grading feedback and how easily they interpreted it. After the exam was graded, all students were sent an online questionnaire, including their personalised exam feedback. The questionnaire was filled in by 36 students, and 4 of them participated in semi-structured interviews. Findings suggest that students could interpret the feedback from checkbox grading well, with no correlation between students' exam scores and feedback understanding. Therefore, we suggest that checkbox grading is an effective way to provide feedback, also for students with shaky subject matter knowledge. [ABSTRACT FROM AUTHOR]

Abstract Background Thailand aimed to eliminate malaria by 2024, and as such is planning for future prevention of re-establishment in malaria free provinces. Understanding the receptivity of local areas to malaria allows the appropriate targeting of interventions. Current approaches to assessing receptivity involve collecting entomological data. Forest coverage is known to be associated with malaria risk, as an environment conducive to both vector breeding and high-risk human behaviours. Methods Geolocated, anonymized, individual-level surveillance data from 2011 to 2021 from the Thai Division of Vector-Borne Disease (DVBD) was used to calculate incidence and estimated Rc at village level. Forest cover was calculated using raster maps of tree crown cover density and year of forest loss from the publicly available Hansen dataset. Incidence and forest cover were compared graphically and using Spearman’s rho. The current foci classification system was applied to data from the last 5 years (2017–2021) and forest cover for 2021 compared between the classifications. A simple risk score was developed to identify villages with high receptivity. Results There was a non-linear decrease in annual cases by 96.6% (1061 to 36) across the two provinces from 2011 to 2021. Indigenous Annual Parasite Index (API) and approximated Rc were higher in villages in highly forested subdistricts, and with higher forest cover within 5 km. Forest cover was also higher in malaria foci which consistently reported malaria cases each year than those which did not. An Rc > 1 was only reported in villages in subdistricts with > 25% forest cover. When applying a simple risk score using forest cover and recent case history, the classifications were comparable to those of the risk stratification system currently used by the DVBD. Conclusions There was a positive association between forest coverage around a village and indigenous malaria cases. Most local transmission was observed in the heavily forested subdistricts on the international borders with Laos and Cambodia, which are where the most receptive villages are located. These areas are at greater risk of importation of malaria due to population mobility and forest-going activities. Combining forest cover and recent case surveillance data with measures of vulnerability may be useful for prediction of malaria recurrence risk.

Background: Thailand aimed to eliminate malaria by 2024, and as such is planning for future prevention of re-establishment in malaria free provinces. Understanding the receptivity of local areas to malaria allows the appropriate targeting of interventions. Current approaches to assessing receptivity involve collecting entomological data. Forest coverage is known to be associated with malaria risk, as an environment conducive to both vector breeding and high-risk human behaviours. Methods: Geolocated, anonymized, individual-level surveillance data from 2011 to 2021 from the Thai Division of Vector-Borne Disease (DVBD) was used to calculate incidence and estimated Rc at village level. Forest cover was calculated using raster maps of tree crown cover density and year of forest loss from the publicly available Hansen dataset. Incidence and forest cover were compared graphically and using Spearman's rho. The current foci classification system was applied to data from the last 5 years (2017–2021) and forest cover for 2021 compared between the classifications. A simple risk score was developed to identify villages with high receptivity. Results: There was a non-linear decrease in annual cases by 96.6% (1061 to 36) across the two provinces from 2011 to 2021. Indigenous Annual Parasite Index (API) and approximated Rc were higher in villages in highly forested subdistricts, and with higher forest cover within 5 km. Forest cover was also higher in malaria foci which consistently reported malaria cases each year than those which did not. An Rc > 1 was only reported in villages in subdistricts with > 25% forest cover. When applying a simple risk score using forest cover and recent case history, the classifications were comparable to those of the risk stratification system currently used by the DVBD. Conclusions: There was a positive association between forest coverage around a village and indigenous malaria cases. Most local transmission was observed in the heavily forested subdistricts on the international borders with Laos and Cambodia, which are where the most receptive villages are located. These areas are at greater risk of importation of malaria due to population mobility and forest-going activities. Combining forest cover and recent case surveillance data with measures of vulnerability may be useful for prediction of malaria recurrence risk. [ABSTRACT FROM AUTHOR]

This paper studies the local receptivity of the Mack-mode instability to localized unsteady blowing and suction (UBS) in a chemical non-equilibrium (CNE) hypersonic boundary layer. The five-species CNE model is employed, and the receptivity efficiency is formulated by use of the residual theorem. Compared with the results for the calorically perfect gas (CPG) model, we find that the real-gas effect enhances the receptivity efficiency remarkably in the majority of the second-mode frequency band, and the enhancement is mainly attributed to the modification of the base flow due to the CNE effect, which is akin to the cold-wall effect in hypersonic boundary layers. Combined with the destabilizing role of the CNE effect on the Mack second mode, it is concluded that the CNE effect would lead to a greater linearly accumulated perturbation amplitude, implying premature of transition to turbulence in a high-enthalpy hypersonic boundary layer subject to localized perturbations. [ABSTRACT FROM AUTHOR]

The disturbances generated by external turbulence in the shear layer on a flat plate suddenly set in motion are found. As the initial conditions, turbulent flow found using direct numerical simulation of the development of isotropic homogeneous turbulence is used. The solution obtained models laminar-turbulent transition in the boundary layer on a flat plate under relatively low free-stream turbulence when the transition is caused by Tollmien–Schlichting waves. The solution makes it possible to describe the process of generating various disturbances, namely, low-frequency streaky structures and instability waves and also their development in the initial stage of laminar-turbulent transition. Based on the processing of the obtained results, a simple model is proposed that relates the spectra of instability waves in the boundary layer and turbulent pulsations in free-stream flow. The dependences of the initial amplitude of instability waves and their critical amplification factors (N-factors) on the degree of flow turbulence are also obtained. [ABSTRACT FROM AUTHOR]

The expression and function of various subtypes of cells in the endometrium are crucial for maintaining normal endometrial function and providing an environment for embryo implantation. In recent years, the single-cell omics has gradually become an important tool for the basic research and clinical application related to endometrium, as it can perform the high-throughput sequencing of endometrium from different sources and stages at the single-cell level. This article provides a systematic review of existing studies on the single-cell omics related to the endometrium, including the physiological status of the endometrium, as well as the single-cell differences and intercellular interactions in pathological conditions such as recurrent spontaneous abortion, endometriosis, adenomyosis, thin endometrium, intrauterine adhesions, repeated implantation failures and endometrial cancer. The deeper understanding of the application of single-cell omics of endometrium is helpful for us to reveal the pathophysiological mechanisms of the endometrium-related diseases. [ABSTRACT FROM AUTHOR]

Preventing and countering potential far-right radicalisation within police forces is a major concern in many countries. Specific interventions such as anti-racism or intercultural competence training programmes for police officers are seen as key to build resilience against the lures of extremist ideologies and milieus. However, a dearth of empirical research investigating the factors that influence receptivity or rejection by the target group – police officers – impedes the design and implementation of effective interventions. This study presents findings from a formative evaluation accompanying a pilot project within the state police of the southern German state of Baden-Wuerttemberg called 'Strategy Sponsorship for Democracy and Tolerance'. Drawing on three focus groups, five individual problem-centred interviews, and 603 feedback reports, the study finds that peer-to-peer approaches, voluntary participation, leadership support, freedom in topic selection and intervention planning, as well as budgetary independence positively impact the acceptance of interventions and motivation to engage. Age of participants, resource constraints and administrative challenges, as well as reservations about project aims and contents were found to increase the risk of rejection. Implications for optimising interventions for police forces are discussed. [ABSTRACT FROM AUTHOR]

In this paper I show my painting process. That is, how I arrange my emotional and physical space together with my medium to allow a receptive and responsive experience of painting. I describe how my use of color allowed me to access previously unavailable aspects of my psychoanalytic work with a patient. Through showing as closely as possible my process as a painter, I hope that the reader will find resonance to their psychoanalytic work. [ABSTRACT FROM AUTHOR]

Objectives: The downregulation of anti-adhesive regulatory proteins and upregulation of adhesive genes are critical for the receptive endometrium. This study was designed to determine whether switching between the anti-adhesive podocalyxin (PDX) and adhesive HOXA10 receptivity modulator occurs in the endometrium of women with recurrent implantation failure (RIF). Methods: Twenty-four patients with RIF who could not conceive for three or more cycles despite good-quality embryo transfer constituted the study group. Twenty-four patients with unexplained infertility (UEI) matched for age, BMI, and infertility duration were included in the control group. Twenty women scheduled to undergo intrauterine device (IUD) placement for birth control were included in the comparative group. Endometrial tissue was collected from patients with RIF and UEI during egg retrieval after ovarian stimulation using the GnRH antagonist protocol. In the fertile group, endometrial tissues were collected during IUD insertion. HOXA10 mRNA expression was analyzed by qRT-PCR and PDX protein expression was analyzed by ELISA. The relative expression of endometrial HOXA10 mRNA was calculated using the 2−ΔΔCt equation. Results: The relative expression of HOXA10 mRNA in the RIF group was significantly lower than that in the UEI group (p < 0.001). HOXA10 mRNA expression in the fertile group was significantly higher than that in the RIF group and was similar to that in the UEI group. PDX expression in the RIF group was significantly higher than that in the UEI group (p < 0.001). PDX expression in the fertile group was significantly lower than in the RIF and UEI groups. A negative correlation was detected between the anti-adhesive PDX protein and adhesive HOXA10 (r = −0.797, p < 0.001). Although there was a positive correlation between endometrial thickness recorded on the day of hCG administration and HOXA10 (r = 0.590, p < 0.01), endometrial thickness was negatively correlated with PDX (r = −0.529, p < 0.01). Conclusions: The failed physiological downregulation of the anti-adhesive PDX protein in patients with RIF prevented the upregulation of adhesive HOXA10 mRNA.

STUDY QUESTION How do plasma progesterone (P) and dydrogesterone (D) concentrations together with endometrial histology, transcriptomic signatures, and immune cell composition differ when oral dydrogesterone (O-DYD) or micronized vaginal progesterone (MVP) is used for luteal phase support (LPS)? SUMMARY ANSWER Although after O-DYD intake, even at steady-state, plasma D and 20αdihydrodydrogesterone (DHD) concentrations spiked in comparison to P concentrations, a similar endometrial signature was observed by histological and transcriptomic analysis of the endometrium. WHAT IS KNOWN ALREADY O-DYD for LPS has been proven to be noninferior compared to MVP in two phase III randomized controlled trials. Additionally, a combined individual participant data and aggregate data meta-analysis indicated that a higher pregnancy rate and live birth rate may be obtained in women receiving O-DYD versus MVP for LPS in fresh IVF/ICSI cycles. Little data are available on the pharmacokinetic (PK) profiles of O-DYD versus MVP and their potential molecular differences at the level of the reproductive organs, particularly at the endometrial level. STUDY DESIGN, SIZE, DURATION Thirty oocyte donors were planned to undergo two ovarian stimulation (OS) cycles with dual triggering (1.000 IU hCG + 0.2 mg triptorelin), each followed by 1 week of LPS: O-DYD or MVP, in a randomized, cross-over, double-blind, double-dummy fashion. On both the first and eighth days of LPS, serial blood samples upon first dosing were harvested for plasma D, DHD, and P concentration analyses. On Day 8 of LPS, an endometrial biopsy was collected for histologic examination, transcriptomics, and immune cell analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS All oocyte donors were <35 years old, had regular menstrual cycles, no intrauterine contraceptive device, anti-Müllerian hormone within normal range and a BMI ≤29 kg/m2. OS was performed on a GnRH antagonist protocol followed by dual triggering (1.000 IU hCG + 0.2 mg triptorelin) as soon as ≥3 follicles of 20 mm were present. Following oocyte retrieval, subjects initiated LPS consisting of MVP 200 mg or O-DYD 10 mg, both three times daily. D, DHD, and P plasma levels were measured using liquid chromatography–tandem mass spectrometry. Histological assessment was carried out using the Noyes criteria. Endometrial RNA-sequencing was performed for individual biopsies and differential gene expression was analyzed. Endometrial single-cell suspensions were created followed by flow cytometry for immune cell typing. MAIN RESULTS AND THE ROLE OF CHANCE A total of 21 women completed the entire study protocol. Subjects and stimulation characteristics were found to be similar between groups. Following the first dose of O-DYD, the average observed maximal plasma concentrations (C max) for D and DHD were 2.9 and 77 ng/ml, respectively. The C max for D and DHD was reached after 1.5 and 1.6 h (= T max), respectively. On the eighth day of LPS, the first administration of that day gave rise to a C max of 3.6 and 88 ng/ml for D and DHD, respectively. For both, the observed T max was 1.5 h. Following the first dose of MVP, the C max for P was 16 ng/ml with a T max of 4.2 h. On the eighth day of LPS, the first administration of that day showed a C max for P of 21 ng/ml with a T max of 7.3 h. All 42 biopsies showed endometrium in the secretory phase. The mean cycle day was 23.9 (±1.2) in the O-DYD group versus 24.0 (±1.3) in the MVP group. RNA-sequencing did not reveal significantly differentially expressed genes between samples of both study groups. The average Euclidean distance between samples following O-DYD was significantly lower than following MVP (respectively 12.1 versus 18.8, Mann–Whitney P  = 6.98e−14). Immune cell profiling showed a decrease of CD3 T-cell, γδ T-cell, and B-cell frequencies after MVP treatment compared to O-DYD, while the frequency of natural killer (NK) cells was significantly increased. LIMITATIONS, REASONS FOR CAUTION The main reason for caution is the small sample size, given the basic research nature of the project. The plasma concentrations are best estimates as this was not a formal PK study. Whole tissue bulk RNA-sequencing has been performed not correcting for bias caused by different tissue compositions across biopsies. WIDER IMPLICATIONS OF THE FINDINGS This is the first study comparing O-DYD/MVP, head-to-head, in a randomized design on a molecular level in IVF/ICSI. Plasma serum concentrations suggest that administration frequency is important, in addition to dose, specifically for O-DYD showing a rapid clearance. The molecular endometrial data are overall comparable and thus support the previously reported noninferior reproductive outcomes for O-DYD as compared to MVP. Further research is needed to explore the smaller intersample distance following O-DYD and the subtle changes detected in endometrial immune cells. STUDY FUNDING/COMPETING INTEREST(S) Not related to this work, C.Bl. has received honoraria for lectures, presentations, manuscript writing, educational events, or scientific advice from Abbott, Ferring, Organon, Cooper Surgical, Gedeon-Richter, IBSA, and Merck. H.T. has received honoraria for lectures, presentations, manuscript writing, educational events, or scientific advice from Abbott, Ferring, Cooper Surgical, Gedeon-Richter, Cook, and Goodlife. S.M. has received honoraria for lectures, presentations, educational events, or scientific advice from Abbott, Cooper Surgical, Gedeon-Richter, IBSA, and Merck and Oxolife. G.G. has received honoraria for lectures, presentations, educational events, or scientific advice from Merck, MSD, Organon, Ferring, Theramex, Gedeon-Richter, Abbott, Biosilu, ReprodWissen, Obseva, PregLem, Guerbet, Cooper, Igyxos, and OxoLife. S.V.-S. is listed as inventor on two patents (WO2019115755A1 and WO2022073973A1), which are not related to this work. TRIAL REGISTRATION NUMBER EUDRACT 2018-000105-23 [ABSTRACT FROM AUTHOR]

Sex steroids are converted to bioactive metabolites and vice versa by endometrial steroid-metabolising enzymes. Studies indicate that alterations in this metabolism might affect endometrial receptivity. This pilot study determined whether the endometrial formation and inactivation of 17β-oestradiol differed between the supposedly embryo-receptive endometrium and non-receptive endometrium of women undergoing IVF/intracytoplasmic sperm injection (ICSI). Endometrial biopsies were obtained from IVF/ICSI patients 5–8 days after ovulation in a natural cycle, prior to their second IVF/ICSI cycle with fresh embryo transfer (ET). Endometrial biopsies from patients who achieved clinical pregnancy after fresh ET (n = 15) were compared with endometrial biopsies from patients that did not conceive after fresh ET (n = 15). Formation of 17β-oestradiol (oxidative 17β-hydroxysteroid dehydrogenases (HSDs)), oestrone (reductive HSD17Bs) and inhibition of HSD17B1 activity were determined by high-performance liquid chromatography. The endometrial transcriptome was profiled using RNA sequencing followed by principal component analysis and differentially expressed gene analysis. The false discovery rate-adjusted P < 0.05 and log fold change >0.5 were selected as the screening threshold. Formation and inactivation of 17β-oestradiol resulted similar between groups. Inhibition of HSD17B1 activity was significantly higher in the non-pregnant group when only primary infertile women (n = 12) were considered (27.1%, n = 5 vs 16.2%, n = 7, P = 0.04). Gene expression analysis confirmed the presence of HSD17B1 (encoding HSD17B1), HSD17B2 (encoding HSD17B2) and 33 of 46 analysed steroid metabolising enzymes in the endometrium. In the primary infertile subgroup (n = 10) 12 DEGs were found including LINC02349 which has been linked to implantation. However, the exact relationship between steroid-metabolising enzyme activity, expression and implantation outcome requires further investigation in larger, well-defined patient groups.

More than 28 million people in the United States visited their dentists but not a physician in 2018, yet only a few states allow dentists to administer vaccines to patients, and those vaccines are limited to influenza, COVID-19, and human papillomavirus. To assess the receptiveness of adult dental patients and caregivers of pediatric dental patients to receive necessary vaccines during their dental appointment, a survey was distributed to patients attending a dental visit at a rural federally qualified health center from June 28, 2021, through December 31, 2021. Among the responses from 643 adult patients and 625 pediatric caregivers, approximately one-half (54.2% and 49.9%, respectively) reported being receptive to receiving vaccines in the dental clinic, with 28.5% and 21.8% not being receptive to vaccines, respectively. Primary language, age group, number of children, and primary care center all were associated significantly with reported likelihood of receiving vaccines (P <.05). The most reported concern about receiving vaccines at a dental clinic was a preference for their primary care physician to provide all vaccinations, according to 22.2% of adult patients and 39.8% of pediatric caregivers. The authors' findings support efforts to administer vaccines during dental visits to improve immunization rates among adults and children. Ongoing communication with primary care physicians regarding administration of vaccines in the dental clinic could reduce concerns by adult patients and pediatric caregivers. Strategies and policies that establish protocols to ensure the safe and effective administration of vaccines in dental visits should be implemented and supported. [ABSTRACT FROM AUTHOR]

This study examined whether an educational television show would affect young Haitian children’s gender perceptions. We first collected data on children’s beliefs about male and female characteristics and roles. Among 862 participating 6- and 7-year-olds from urban, peri-urban, and rural settings, we saw gender stereotypical beliefs about activities, traits, and occupations. We conducted a school-based intervention over a 10-week period, in which children were randomly assigned to watch a children’s television program in either of two groups: one that watched Lakou Kajou or one that watched Dora the Explorer. Each group saw 21 episodes of its assigned show, spread over 3 screenings of 7 episodes each. Lakou Kajou is an educational television show created in Haiti that purposely incorporates overt counter-stereotypical gender messaging. Among those children who watched Lakou Kajou and recalled more characters from the show, beliefs around gender became less stereotypical. In countries like Haiti, where pronounced gender disparities and biases exist, it is encouraging to see that a locally produced educational television show can change beliefs. [ABSTRACT FROM AUTHOR]

Objective: In this retrospective study, we analyzed factors influencing the ongoing pregnancy rate (PR) in women with repeated implantation failure (RIF) undergoing embryo transfer with endometrial receptivity array (ERA). Methods: Eighty-three consecutive personalized embryo transfers (pETs) with ERA, from 54 women with RIF, were selected from June 2020 to April 2022. Vitrified blastocyst transfer was timed based on ERA results. Results: The ongoing PR per pET was 33.7%. Using ERA, the endometrium was identified as pre-receptive in 26 cycles, early receptive in 25 cycles, receptive in 31 cycles, and late receptive in one cycle. With cycles categorized into three receptivity phases (pre-receptive, early receptive, or receptive), no significant differences were found in the clinical PR (27.3%, 55.6%, and 40%, respectively) or ongoing PR (9.1%, 55.6%, and 40%, respectively) after a single blastocyst transfer. Similarly, no significant differences were observed in the clinical PR or ongoing PR after the transfer of two or more blastocysts. Among women with ongoing pregnancy relative to those without, age at first pET was significantly lower (35 years vs. 39 years, p=0.001), while blastocyst score (23 vs. 18, p=0.012) and the proportion of blastocyst scores >18 (71.4% vs. 38.9%, p=0.005) were significantly higher. In multiple logistic regression analysis, the woman's age (odds ratio [OR], 0.814; 95% confidence interval [CI], 0.706 to 0.940; p=0.005) and blastocyst score >18 (OR, 3.052; 95% CI, 1.075 to 8.665; p=0.036) were identified as significant factors influencing ongoing pregnancy. Conclusion: In pET with ERA, ongoing pregnancy was closely associated with woman's age and blastocyst quality. [ABSTRACT FROM AUTHOR]

Numerical simulation of the receptivity of a supersonic boundary layer on a flat pointed plate with respect to model acoustic disturbances that propagate in the free-stream flow (Mach number is equal to 5) and are characteristic of the background noise of shock wind tunnels is carried out within the framework of the full Navier–Stokes equations. Spectral analysis of the perturbations induced in the boundary layer is carried out. A method for restoring the amplitude of an acoustic disturbance in free-stream flow by measuring the pressure fluctuations on the plate surface is discussed. [ABSTRACT FROM AUTHOR]

We defend in this essay Paul Ricœur’s hermeneutics of suspicion against Toril Moi’s debunking of it as a misguided interpretation of the practice of critical inquiry, and we relate the practice of a rigorous and critical empathy to the hermeneutics of suspicion. For Ricœur, empathy would not be a mere psychological mechanism by which one subject transiently identifies with another, but the ontological presence of the self with the Other as a way of being —listening as a human action that is a fundamental way of being with the Other in which “hermeneutics can stand on the authority of the resources of past ontologies.” In a rational reconstruction of what a Ricœur-friendly approach to empathy would entail, a logical space can be made for empathy to avoid the epistemological paradoxes of Husserl and the ethical enthusiasms of Levinas. How this reconstruction of empathy would apply to empathic understanding, empathic responsiveness, empathic interpretation, and empathic receptivity is elaborated from a Ricœurian perspective.

In speech act theory, we say there has been successful uptake of a speech act when a hearer has understood what the speaker was trying to say to them. I argue that it is possible to be understood without having what you say taken seriously. For a speech act to be without defect, then, hearers must not only take up the speech act, but also be open to responding to it in appropriate ways. I call this kind of openness receptivity and argue that it should be analysed as a kind of responsiveness to reasons. A receptive hearer takes the speaker's speech act as appropriately reason giving, while an unreceptive hearer does not. This analysis reveals subtle forms of communicative breakdown that bear similarities to phenomena such as illocutionary silencing and distortion but are both posterior to, and compatible with, uptake. The analysis also helps us understand how illocutionary acts give rise to specific perlocutionary effects by way of the hearer's practical reasoning. [ABSTRACT FROM AUTHOR]

LIF is crucial in regulating embryo implantation, while HOXA10 is a marker gene for uterine receptivity. However, the specific mechanism of LIF regulating HOXA10 during cow embryo implantation has not been fully understood. To address this knowledge gap, the experiment involved treating bovine endometrial epithelial cells (BEECs) with LIF to investigate the relationship between LIF, miRNA, and HOXA10. The experimental findings revealed that applying LIF resulted in a substantial increase in the proliferation of endometrial epithelial cells. Moreover, the expressions of PI3K , AKT , HOXA10, CDK4 , cyclinD1 , and cyclinE1 were significantly elevated. Conversely, the expression of p21Cipl was significantly reduced. In the group that received a combination of LIF and a STAT3 inhibitor, the expression of PI3K/AKT remained significantly increased, but there was no significant change in the expression of HOXA10. When miRNA-27a-3p was overexpressed, it resulted in a decrease in both the RNA and protein expression of HOXA10. Conversely, inhibiting miRNA-27a-3p increased the RNA and protein expression of HOXA10. In the presence of LIF treatment, the expression of miRNA-27a-3p was reduced, while the expression of HOXA10 was increased. However, when LIF and a STAT3 inhibitor were combined, there was no significant change in the expression of miRNA-27a-3p or HOXA10. Consequently, LIF facilitated cell proliferation by activating the PI3K/AKT pathway. LIF controlled the expression of miRNA-27a-3p and HOXA10 in endometrial epithelial cells through STAT3, with miRNA-27a-3p negatively regulating the expression of HOXA10. • LIF promotes cell proliferation by activating the PI3K/AKT pathway. • LIF regulates the expression of miRNA-27a-3p and HOXA10 in endometrial epithelial cells through STAT3 pathway. • miRNA-27a-3p negatively regulates the expression of HOXA10. [ABSTRACT FROM AUTHOR]

In the paper (Theoret Comput Fluid Dyn 36:705–722, 2022), we analyzed acoustic receptivity of the boundary layer on a flat plate in Mach 6 flow at various angles of attack (AoA). It was shown that slow and fast acoustic waves passing through: a bow shock at AoA = - 5 ∘ , a weak shock induced by the viscous–inviscid interaction at AoA = 0 ∘ , or an expansion fan at AoA = 5 ∘ , excite dominant modes F and S in a small vicinity of the plate leading edge. The present paper extends this analysis to the cases of receptivity to entropy and vorticity waves. Similar to the case of acoustic receptivity, modes F and S of about equal amplitude are excited in a small vicinity of the plate leading edge. These modes propagate downstream in accord with the two-mode approximation model accounting for the mean-flow nonparallel effects and the intermodal exchange mechanism. Cross-comparisons of the initial amplitudes of excited modes help to evaluate the relative role of acoustic, entropy and vorticity waves in the second-mode dominated transition. [ABSTRACT FROM AUTHOR]

Starting from Edmund Husserl's last book Experience and Judgement, this paper explores the notions of "passivity" and "receptivity" in phenomenology and psychoanalysis. Both sciences agree that receptivity differs from passivity, but they have developed different conceptualizations about the very nature of the rudimentary "ego-activity" which is the source of receptivity. In phenomenological terms, "pre-predicative" experience roots in a primary presence and openness of the ego towards the world, whilst psychoanalysis has emphasized the role of projective and introjective processes which are close to bodily experiences and unconscious phantasy. The second part of the paper draws some conclusions concerning the analytic situation, in particular the shift among receptivity, empathy, curiosity and creative imagination as central features of the analytic attitude from a mainly Kleinian point of view. The paper argues that receptivity is a field where phenomenological and psychoanalytic approaches can mutually enrich and learn from each other. [ABSTRACT FROM AUTHOR]

Purpose: Investigate whether local angiotensin II (AngII) and its AngII type 1 and 2 receptors (AT1R, AT2R) in the endometrium are different and correlate with microvessel density in women with reproductive failure and pregnancy outcomes. Methods: Endometriumduring the window of implantation from40 women with recurrent miscarriage (RM) and 40 with recurrent implantation failure (RIF) were compared with 27 fertile women. Peri-implantation endometrium from 54 women prior to euploid embryo transfer were collected and compared in women with successful pregnancy and unsuccessful pregnancy. Results: Compared with fertile women, expression of AT2R was significantly lower, while AT1R/AT2R expression ratio was significantly higher in the stroma of the RIF group. Endometriumarteriole MVD was significantly lower and negatively correlated with the AT1R/AT2R expression ratio in the stroma of the RIF group. No significant differences and correlations were found in the RM group. Compared with the pregnancy group, expression of AT1R and AT2R were significantly lower in all compartments, but only AT1R/AT2R ratio was significantly higher in the stroma of the non-pregnancy group. Similarly, endometrium arteriole MVD was also significantly lower and negatively correlated with the AT1R/AT2R ratio in the stroma of the non-pregnancy group. Conclusion: Local renin-angiotensin system is dysregulated in peri-implantation endometrium and associated with abnormal angiogenesis in RIF and poor implantation outcome after embryo transfer. [ABSTRACT FROM AUTHOR]

Endometrial scratching (ES) has been widely used in assisted reproductive technology to possibly improve pregnancy rates, but its exact mechanism is still not understood or investigated, and its benefits are controversially discussed. Hypothetically, ES may trigger a local immune response, leading to an improved endometrial receptivity. So far, it has been shown that ES affects the gene expression of cytokines, growth factors, and adhesive proteins, potentially modulating inflammatory pathways and adhesion molecule expression. Our pilot study applying proteomic analysis reveals that ES probably has an impact on the proteins involved in immune response pathways and cytoskeleton formation, which could potentially increase endometrial receptivity. Specifically, proteins that are involved in the immune response and cytoskeleton regulation showed a trend toward higher abundance after the first ES. On the other hand, proteins with a decreasing abundance after the first ES play roles in the regulation of the actin cytoskeleton and cellular processes such as intracellular transport, apoptosis, and autophagy. These trends in protein changes suggest that ES may affect endometrial tissue stiffness and extracellular matrix remodeling, potentially enhancing the embryos' implantation. To our knowledge, this pilot study provides, for the first time, data investigating potential changes in the endometrium due to the scratching procedure that might explain its possible benefit for patients in infertility treatment. Furthermore, the proteome of a group of patients suffering from repeated implantation failure was compared to that of the fertile group in order to transfer the basic science to clinical routine and application. [ABSTRACT FROM AUTHOR]

The effect of external nozzle geometry on the emission of screech tones was studied experimentally. Four conical reflector surfaces, with half-angles ranging from 60° to 90°, were installed around the exit of a round convergent nozzle. The investigation focused on two closely spaced fully-expanded Mach numbers, M j = 1.32 and 1.34. The acoustic far-field was surveyed by a microphone phased array that included a continuously-scanning microphone, the latter enabling high spatial resolution. The isolated jets contained well-known screech mode B and its harmonics. Addition of the reflectors caused significant changes in the modal emission pattern, with tones traditionally linked to mode C occurring at M j = 1.34 but not at M j = 1.32. Tonal components associated with new modes E and F emerge at both Mach numbers when the cone half-angle is 60° or 70°. The noise source distribution generally elongates with decreasing cone angle. Some modes show clear scattering from the reflectors, while others do not. The study underscores the complexity that initial conditions can impart on the modal structure of screech and demonstrates the capability of the continuous-scan beamforming technique in resolving fine features of the source. [ABSTRACT FROM AUTHOR]

In ecumenical social action and mission it is common to hear phrases like, 'denomination doesn't matter', and 'we are all just Christians'. This reflects a wider tension with modern ecumenism between doctrinal and practice-based approaches to ecumenism. In this theological action research project on Methodists and Catholics engaging together in social action many espoused this pragmatic approach to action over ecclesial tradition. However, in practice they engaged with the complexities of ecumenical life and ecclesial tradition, many in significant ways. Drawing on the themes of receptivity, identity and practical wisdom seen in their practice and their understanding of ecumenism as something which is 'lived' rather than 'done', I offer a receptive ecumenical missiology. This ecumenical missiology, based in a pneumatological receptivity, offers an integrated way forward, overcoming many of the tensions between practice, mission and doctrine felt within modern ecumenism. [ABSTRACT FROM AUTHOR]

Copyright of Ricoeur Studies / Etudes Ricoeuriennes is the property of University of Pittsburgh, University Library System and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Austral de Ciencias Sociales is the property of Facultad de Filosofia y Humanidades, Intituto de Ciencias Sociales, Universidad Austral de Chile and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This essay explores the challenge that men's experiences of uncertainty, vulnerability and dependency pose for phallic masculinity. The theory of the little boy's disidentification from the mother is revisited to account for a fear of drowning in a sea of overwhelming affect, as exemplified by my own experiences as father and psychoanalytic candidate. I argue that men's ability to tolerate the unconscious depends on their relationship to the maternal, which is forged on the threshold between preoedipal and oedipal functioning. The importance of receptive fathers to help men integrate the maternal is illustrated by a case discussion in which an early impasse is resolved in supervision. [ABSTRACT FROM AUTHOR]

Purpose: To investigate the possibility that altered actions of endogenous progesterone affect receptivity and contribute to unexplained infertility (UI). Methods: Two authors electronically searched MEDLINE, CINAHL and Embase databases from inception to 6 July 2022 and hand-searched according to Cochrane methodology. We included all published primary research reporting outcomes related to endogenous progesterone in natural cycles in women with UI. Studies were assessed for risk of bias using a modified Newcastle–Ottawa Score or NHLBI Score. We pooled results where appropriate using a random-effects model. Findings were reported as odds ratios or mean differences. Results: We included 41 studies (n = 4023). No difference was found between the mid-luteal serum progesterone levels of women with UI compared to fertile controls (MD 0.74, − 0.31–1.79, I2 36%). Women with UI had significantly higher rates of 'out-of-phase' endometrium than controls. Nine out of 10 progesterone-mediated markers of endometrial receptivity were significantly reduced in women with UI compared to fertile controls (the remaining 1 had conflicting results). Resistance in pelvic vessels was increased and perfusion of the endometrium and sub-endometrium reduced in UI compared to fertile controls in all included studies. Progesterone receptor expression and progesterone uptake were also reduced in women with unexplained infertility. Conclusions: End-organ measures of endogenous progesterone activity are reduced in women with UI compared to fertile controls. This apparently receptor-mediated reduction in response affects endometrial receptivity and is implicated as the cause of the infertility. Further research is required to confirm whether intervention could overcome this issue, offering a new option for treating unexplained infertility. Trial registration: PROSPERO registration: CRD42020141041 06/08/2020. [ABSTRACT FROM AUTHOR]

To reveal whether hysteroscopic removal of the International Federation of Gynecology and Obstetrics (FIGO) types 0 and 1 fibroids makes any changes in the expression of homeobox genes (HOXA10 , HOXA11), leukemia inhibitory factor, and nuclear factor-kappa B (NF-kB). A case-control study. University-based in vitro fertilisation center. This study consisted of a total of 29 participants, 21 with FIGO types 0 and 1 fibroids and 8 with normal uterine cavity without fibroids. Patients in FIGO types 0 and 1 fibroids group underwent hysteroscopic myomectomy. The patients in the control group underwent laparoscopic tubal ligation. Endometrial cells were collected by flushing method from all participants before and 3 months after myomectomy. Real-time polymerase chain reaction was used to detect HOXA10, HOXA11, and LIF mRNA expressions in endometrial flushing samples. The relative expressions of homeobox and LIF mRNA were calculated with comparative ΔCt method. Endometrial NF-kB concentration was measured quantitatively by enzyme-linked immunosorbent assay. To compare endometrial HOXA10, HOXA11, and LIF mRNA expressions as well as endometrial NF-kB concentration before and after myomectomy. Premyomectomy NF-kB levels of type 0 (4.22 ± 1.02 ng/mL) and type 1 fibroid (6.44 ± 2.30 ng/mL) were significantly higher than the values of control group (0.54 ± 0.10 ng/mL). Surgical removal of type 0 and 1 fibroids resulted in a significant decrease in endometrial NF-kB levels (1.33 ± 0.02 ng/mL vs 1.65 ± 0.27 ng/mL, respectively). In type 0 fibroid group, after myomectomy, there was a 11.1-fold increase in HOXA10 mRNA, 4.23-fold in HOXA11 mRNA, and 7.63-fold in LIF mRNA. In the type 1 fibroid group, after myomectomy, there was a 16.3-fold increase in HOXA10 mRNA, 8.34-fold in HOXA11 mRNA, and 9.38-fold in LIF mRNA. A nonsignificant change was detected in homeobox and LIF mRNA after tubal sterilization. A negative and significant correlation was found between endometrial NF-kB and HOXA10 (r=-0.67), HOXA11 (r=-0.71) and LIF (r=-0.54). High proinflammatory NF-kB concentration and low homeobox and LIF mRNA expressions were detected in the presence of type 0 or 1 fibroids that returned to normal values after hysteroscopic myomectomy. [ABSTRACT FROM AUTHOR]

Successful embryo implantation into a receptive endometrium requires mutual endometrial-embryo communication. Recently, the function of extracellular vehicles (EVs) in cell-to-cell interaction in embryo-maternal interactions has been investigated. We explored isolated endometrial-derived EVs, using RL95-2 cells as a model of a receptive endometrium, influenced by the menstrual cycle hormones estrogen (E2; proliferative phase), progesterone (P4; secretory phase), and estrogen plus progesterone (E2P4; the receptive phase). EV sized particles were isolated by differential centrifugation and size exclusion chromatography. Nanoparticle tracking analysis was used to examine the different concentrations and sizes of particles and EV proteomic analysis was performed using shotgun label-free mass spectrometry. Our results showed that although endometrial derived EVs were secreted in numbers independent of hormonal stimulation, EV sizes were statistically modified by it. Proteomics analysis showed that hormone treatment changes affect the endometrial EV's proteome, with proteins enhanced within the EV E2P4 group shown to be involved in different processes, such as embryo implantation, endometrial receptivity, and embryo development, supporting the concept of a communication system between the embryo and the maternal endometrium via EVs. [ABSTRACT FROM AUTHOR]

Laminar-to-turbulent transition in a swept flat-plate boundary layer is caused by the breakdown of the crossflow vortex via high-frequency secondary instability and is promoted by the wall-surface roughness and the freestream turbulence (FST). Although the FST is characterized by its intensity and wavelength, it is not clear how the wavelength affects turbulent transitions and interacts with the roughness-induced transition. The wavelength of the FST depends on the wind tunnel or in-flight conditions, and its arbitrary control is practically difficult in experiments. By means of direct numerical simulation, we performed a parametric study on the interaction between the roughness-induced disturbance and FST in the Falkner–Skan–Cooke boundary layer. One of our aims is to determine the critical roughness height and its dependence on the turbulent intensity and peak wavelength of FST. We found a suppression and promotion in the transition process as a result of the interaction. In particular, the immediate transition behind the roughness was delayed by the long-wavelength FST, where the presence of FST suppressed the high-frequency disturbance emanating from the roughness edge. Even below the criticality, the short-wavelength FST promoted a secondary instability in the form of the hairpin vortex and triggered an early transition before the crossflow-vortex breakdown with the finger vortex. Thresholds for the FST wavelengths that promote or suppress the early transition were also discussed to provide a practically important indicator in the prediction and control of turbulent transitions due to FST and/or roughness on the swept wing. [ABSTRACT FROM AUTHOR]