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2 results on '"pyroglutamylated apelin 13"'

1. The effects of apelin treatment on a rat model of type 2 diabetes

Author

Raziye Akcılar, T. Olgun Özcan, Vildan Caner, Aydın Akcılar, Levent Elmas, Sebahat Turgut, and Ceylan Ayada

Subjects
Male, blood pressure measurement, medicine.medical_treatment, insulin blood level, Blood Pressure, Type 2 diabetes, angiotensin II, Wistar rat, Receptors, G-Protein-Coupled, molecular pathology, renin angiotensin aldosterone system, Alloxan, Insulin, Glucose homeostasis, rat, animal, genetics, glucose, pyroglutamylated apelin 13, Apelin Receptors, Glucose metabolism, vascular tissue, messenger RNA, non insulin dependent diabetes mellitus, General Medicine, Apelin, Apelin receptor (APJ), Type II diabetes, Glucose, apelin receptor, unclassified drug, apelin, antidiabetic activity, real time polymerase chain reaction, Animals, Blood Pressure/drug effects, Diabetes Mellitus, Type 2/*blood/*drug therapy/metabolism, Hypoglycemic Agents/metabolism/therapeutic use, Insulin/blood, Intercellular Signaling Peptides and Proteins/genetics/metabolism/*therapeutic use, RNA, Messenger/metabolism, Rats, Rats, Wistar, Receptors, G-Protein-Coupled/genetics, Intercellular Signaling Peptides and Proteins, angiotensin blood level, heart weight, medicine.medical_specialty, APLNR protein, human, APLN protein, human, animal experiment, Adipokine, G protein coupled receptor, heart, Article, animal tissue, peptide derivative, body weight, blood, Diabetes mellitus, Internal medicine, medicine, Hypoglycemic Agents, endothelin 1, signal peptide, controlled study, RNA, Messenger, Autocrine signalling, Apelin receptor, nonhuman, business.industry, animal model, antidiabetic agent, medicine.disease, enzyme linked immunosorbent assay, angiotensinogen, glucose blood level, Endocrinology, Diabetes Mellitus, Type 2, protein blood level, drug effects, gene expression, business, metabolism, Blood pressure
Abstract

Purpose: Apelin is an adipokine that plays a role in the regulation of many biological functions in mammals including the neuroendocrine, cardiovascular, immune systems, glucose homeostasis and obesity. It can act via autocrine, paracrine, endocrine, and exocrine signaling. We aimed to identify the role of apelin pathophysiology of diabetes. Material/methods: 37 male Wistar Albino rats aged 8-10 weeks were divided in four experimental groups as: control group (C) control + apelin group (C + A), diabetic group (D) diabetic + apelin group (D + A). Apelin and apelin receptor mRNA gene expressions in heart and aorta tissue were determined by real-time polymerase chain reaction. The plasma levels of insulin and plasma apelin were determined by ELISA. Results Plasma levels of insulin, glucose, blood pressure levels were significantly lower in D + A group. There was no statistically significant difference for level of apelin between diabetic groups. On the other hand, differences for apelin and APJ mRNA expression in heart and vascular tissue were found significant between groups. Conclusions: Apelin can be used as a therapeutic agent in the treatment of type II diabetes in the future. © 2014 Medical University of Bialystok., 2011 SBE001, This study was supported by Pamukkale University Research Fund (Project No.: 2011 SBE001).

Published
2015

2. Apelin effects on blood pressure and RAS in DOCA-salt-induced hypertensive rats

Author

Raziye Akcılar, Levent Elmas, Vildan Caner, Aydın Akcılar, T. Olgun Özcan, Ceylan Ayada, and Sebahat Turgut

Subjects
Male, systolic blood pressure, Physiology, blood pressure measurement, Angiotensinogen, drinking, Blood Pressure, angiotensin II, Deoxycorticosterone acetate-salt hypertension, Receptors, G-Protein-Coupled, Renin-Angiotensin System, rat, Aorta, pyroglutamylated apelin 13, Apelin Receptors, Endothelin-1, messenger RNA, tap water, article, General Medicine, protein function, Hypertensive heart disease, Apelin, apelin receptor, unclassified drug, apelin, real time polymerase chain reaction, sodium chloride, Hypertension, Blood pressure, Intercellular Signaling Peptides and Proteins, Angiotensin-Converting Enzyme 2, Apelin receptor (APJ), Cardiac function curve, medicine.medical_specialty, animal experiment, dipeptidyl carboxypeptidase, heart, Peptidyl-Dipeptidase A, animal tissue, deoxycorticosterone acetate, body weight, Desoxycorticosterone Acetate, Internal medicine, Renin–angiotensin system, Internal Medicine, medicine, Animals, endothelin 1, controlled study, RNA, Messenger, Rats, Wistar, plasma, Apelin receptor, nonhuman, treatment duration, business.industry, Myocardium, Deoxycorticosterone acetate (DOCA), medicine.disease, Angiotensin II, Rats, drug efficacy, Endocrinology, protein analysis, Pathophysiology of hypertension, protein blood level, aorta tissue, business, recombinant protein
Abstract

Apelin, a novel multifunctional peptide implicated in the regulation of the cardiovascular system, including blood pressure and cardiac function control, has been postulated to be involved in the pathophysiology of hypertension and hypertensive heart disease. The aim of this study was to investigate, for the first time, whether the effects of apelin's chronic application might be involved in deoxycorticosterone acetate-salt-induced hypertensive rats (DOCA-salt rats). In this study, 8-10-week-old male Wistar rats were divided into four groups: control, control + apelin, DOCA-salt rats, DOCA-salt rats + apelin. Deoxycorticosterone Acetate (25 mg/kg of body weight) was injected subcutaneously, twice a week for 4 weeks. These rats received NaCl 1% instead of tap water for drinking during the experimental period. Later, rats were randomly treated with pyroglutamylated apelin-13 (200 µg. kg-1. day-1 intraperitonealy) for 17 days. The concentrations of apelin, endothelin-1, angiotensin-converting enzyme, angiotensinogen, and angiotensin II were analyzed in the plasma. The mRNA level of apelin and apelin receptor were determined in the heart and aorta tissue by real-time polymerase chain reaction, respectively. It was found that apelin reduces blood pressure in DOCA-salt rats. Apelin can be used as a therapeutic agent in the treatment of hypertension in the future. © 2013 Informa Healthcare USA, Inc., 2011 SBE001, This study was supported by Pamukkale University Research Fund (Project no: 2011 SBE001).

Published
2013

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