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In the last decades, cities have increased the number of activities and services that depends on an efficient and reliable electricity service. In particular, households have had a sustained increase of electricity consumption to perform many residential activities. Thus, providing efficient methods to enhance the decision making processes in demand-side management is crucial for achieving a more sustainable usage of the available resources. In this line of work, this article presents an optimization model to schedule deferrable appliances in households, which simultaneously optimize two conflicting objectives: the minimization of the cost of electricity bill and the maximization of users satisfaction with the consumed energy. Since users satisfaction is based on human preferences, it is subjected to a great variability and, thus, stochastic resolution methods have to be applied to solve the proposed model. In turn, a maximum allowable power consumption value is included as constraint, to account for the maximum power contracted for each household or building. Two different algorithms are proposed: a simulation-optimization approach and a greedy heuristic. Both methods are evaluated over problem instances based on real-world data, accounting for different household types. The obtained results show the competitiveness of the proposed approach, which are able to compute different compromising solutions accounting for the trade-off between these two conflicting optimization criteria in reasonable computing times. The simulation-optimization obtains better solutions, outperforming and dominating the greedy heuristic in all considered scenarios. Fil: Rossit, Diego Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería; Argentina Fil: Nesmachnow, Sergio. Universidad de la República; Uruguay Fil: Toutouh, Jamal. Universidad de Málaga. Departamento de Lenguajes y Ciencias de la Computación; España Fil: Luna, Francisco. Universidad de Málaga. Departamento de Lenguajes y Ciencias de la Computación; España

There is significant environmental concern about chlorinated organic compounds (COCs) in wastewater, surface water, and groundwater due to their low biodegradability and high persistence. In this work, 1,2,4-trichlorobenzene (124-TCB) was selected as a model compound to study its abatement using wet peroxide oxidation at neutral pH with goethite as a heterogeneous catalyst, which was enhanced with visible monochromatic light-emitting diode (LED) light (470 nm). A systematic study of the main operating variables (oxidant and catalyst concentration and irradiance) was accomplished to investigate their influence in the abatement of 124-TCB in water. The reaction was carried out in a well-mixed reactor of glass irradiated by a visible LED light. The hydrogen peroxide concentration was tested from 0 to 18 mM, the goethite concentration within the range 0.1–1.0 g·L−1 and the irradiance from 0.10 to 0.24 W·cm−2 at neutral pH. It was found that this oxidation method is a very efficient technique to abate 124-TCB, reaching a pollutant conversion of 0.9 when using 0.1 g·L−1 of goethite, 18 mM of H2O2, and 0.24 of W·cm−2 . Moreover, the system performance was evaluated using the photonic efficiency (ratio of the moles of 124-TCB abated and the moles of photons arriving at the reactor window). The maximum photonic efficiencies were obtained using the lowest lamp powers and moderate to high catalyst loads. Fil: Lorenzo, David. Universidad Complutense de Madrid; España Fil: Santos, Aurora. Universidad Complutense de Madrid; España Fil: Sánchez-Yepes, Andrés. Universidad Complutense de Madrid; España Fil: Conte, Leandro Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Domínguez, Carmen María. Universidad Complutense de Madrid; España

This work presents an extended and age-band compartmentalised SEIR model that allows describing the spread evolution of SARS-CoV-2 and evaluating the effect of different detection rates, vaccination strategies or immunity periods. The model splits up the population into fifteen age groups of 5 years each, linked through a statistical interaction matrix that includes seventeen health states within each age group. An age-dependent transmission rate takes into account infectious between the groups as well the effect of interventions such as quarantines and mobility restrictions. Further, the proposal includes a nonlinear switched controller for model tuning purposes guarantying a simple and fast adjusting process. To illustrate the model potentials, the particular case of COVID-19 evolution in Argentina is analysed by simulation of three scenarios: (i) different detection levels combined with mobility restrictions, (ii) vaccination campaigns with re-opening of activities and (iii) vaccination campaigns with possible reinfections. The results exhibit how the model can aid the authorities in the decision making process. Fil: Inthamoussou, Fernando Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina Fil: Valenciaga, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina Fil: Nuñez, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina

La eficiencia energética consiste en lograr un menor consumo de energía frente a una misma prestación. La distinta cantidad de radiación solar que es reflejada o absorbida se debe al color de la superficie. Las tejas desarrolladas en esta investigación son de color negro, por tener partículas de caucho en su composición, que contienen negro de humo. Los colores oscuros tienen una absortividad solar mayor, por lo tanto, se analizó la alternativa de colorear las tejas con colores claros, para reducir la absorción de radiación solar. El objetivo es evaluar distintas posibilidades técnicas para la coloración de tejas a partir de la incorporación de pigmentos, y determinar el rendimiento energético. Para la fabricación, se incorporaron óxidos, masterbatch, caucho y polietileno de color. Se realizaron experiencias variando sus dosificaciones y para la determinación del comportamiento termo-físico de las tejas se testearon propiedades ópticas (albedo y emisividad) y temperatura superficial de 2 unidades muestrales -una teja coloreada en verde y una en negro-. El grupo con mejores resultados fue el número 3, donde se mezcla el caucho negro, el polietileno verde y el masterbatch. Al comparar el desempeño termo-físico de tejas recicladas color verde en relación a tejas color negro, se observó un comportamiento más eficiente en las tejas de color verde. Se registraron incrementos en el nivel de albedo del 11% y disminuciones de temperatura superficial superior a 8°C. Energy efficiency consists of achieving lower energy consumption compared to the same benefit The different amount of solar radiation that is reflected or absorbed is due to the surface color. The tiles developed in this research are black, as they have rubber particles in their composition, which contain carbon black. Dark colors have a higher solar absorptivity, therefore, the alternative of coloring the tiles with light colors was analyzed, to reduce the absorption of solar radiation. The objective is to evaluate different technical possibilities for laying tiles from the incorporation of pigments, and to determine the energy efficiency. For manufacturing, colored oxides, masterbatch, rubber and polyethylene were incorporated. Experiments were carried out varying their dosages and for the determination of the thermo-physical behavior of the tiles, optical properties (albedo and emissivity) and surface temperature of 2 sample units were tested -one tile colored in green and one in black-. The group with the best results was number 3, where black rubber, green polyethylene and masterbatch were mixed. When comparing the thermo-physical performance of recycled green tiles in relation to black tiles, a more efficient behavior was observed in green tiles. Increases in the albedo level of 11% and decreases in surface temperature greater than 8 ° C were recorded Fil: Sanchez Amono, Maria Paz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro Experimental de la Vivienda Económica; Argentina Fil: Sulaiman, Halimi Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro Experimental de la Vivienda Económica; Argentina Fil: Alchapar, Noelia Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ambiente, Hábitat y Energía; Argentina Fil: Gaggino, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro Experimental de la Vivienda Económica; Argentina Fil: Correa Cantaloube, Erica Norma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ambiente, Hábitat y Energía; Argentina

El estado, en el marco de una estrategia de desarrollo frente al riesgo y la vulnerabilidad que implican el déficit habitacional, promueve políticas de vivienda que inciden en la trasformación del espacio y en la configuración de las territorialidades de la población. Sin embargo, las prácticas y representaciones estatales sobre las problemáticas del hábitat responden al grado de hegemonía que ejerce, imponiéndose sobre las condiciones locales del hábitat y los marcos socio-culturales. En tal sentido, el trabajo analiza la lógica de territorialización derivada de las conceptualizaciones implicadas en la Ley provincial Nº 6.758/05, declarada para la producción de viviendas rurales en la provincia de Santiago del Estero. Para ello, este trabajo hizo hincapié sobre cuatro ejes: la delimitación del problema/solución habitacional, las directivas respecto al proceso de ejecución de la política, los destinatarios y la solución habitacional. Se observó que la política de vivienda rural basada en esta Ley, incidiría en el espacio implicando un proceso de desterritorialización por la modificación de las características del sistema de habitar previo y otro de reterritorialización por la ocupación del nuevo sistema. The state, within the framework of a development strategy in face of the risk and vulnerability implied by the housing deficit, promotes housing policies that influence the transformation of space and the configuration of the population’s territorialities. However, state practices and representations on habitat prob- lems respond to the degree of hegemony that it exerts, imposing itself on local habitat conditions and socio-cultural frameworks. In this sense, this work ana- lyzes the logic of territorialization derived from the conceptualizations implied in Provincial Law No. 6.758/05, enacted for the production of rural housing in Santiago del Estero province. To achieve that goal, this work focused on four axes: the delimitation of the housing problem / solution, the guidelines regarding the policy execution process, the beneficiary and the housing solution. It was observed that the rural housing policy based on this Law would affect the space, implying a process of deterritorialization due to the modification of the characteristics of the previous dwelling system and another of reterritorialization due to the occupation of the new system. O Estado, em um contexto de estratégia de desenvolvimento perante o risco e a vulnerabilidade que gera o déficit habitacional, promove políticas de moradia que incidem na transformação do espaço e na configuração das territorialidades da população. Porém, as práticas e representações sobre as problemáticas de hábitat respondem ao grau de hegemonia que exerce, impondose sobre as condições locais de hábitat e espaço sociocultural. Neste sentido, o trabalho analisa a lógica de territorialização derivada das conceptualizações da Lei Provincial N° 6758/05, declarada para a produção de moradias rurais na província de Santiago del Estero. Para isso, este trabalho pus o eixo em: a delimitação do problema/solução habitacional, as diretrizes a respeito do processo de execução da política, os destinatários e a solução habitacional. Observouse que a política da moradia rural baseada nesta Lei, influi no espaço participando de um processo de desterritorialização pelas modificações das características do sistema de habitar prévio e outro de reterritorialização pela ocupação do novo sistema. Fil: Olivarez, Joaquin Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet Noa Sur. Instituto de Estudios para el Desarrollo Social. - Universidad Nacional de Santiago del Estero. Facultad de Humanidades Ciencias Sociales y de la Salud. Instituto de Estudios para el Desarrollo Social; Argentina Fil: Rolon, Carlos Guillermo. Universidad Nacional de Tucuman. Instituto de Investigaciones Territoriales y Tecnologicas Para la Produccion del Habitat. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet Noa Sur. Instituto de Investigaciones Territoriales y Tecnologicas Para la Produccion del Habitat.; Argentina. Universidad Nacional de Tucuman. Facultad de Arquitectura y Urbanismo. Centro Regional de Inv. de Arquitectura de Tierra Cruda; Argentina

Microbial food alterations lead to unfit products for consumption, and their discarding, to significant economic losses for the food industry. During storage, fresh foods offer available niches for the survival and growth of undesirable microorganisms. In dairy products, data regarding spoilage and/or pathogenic bacteria is better documented than those for molds and yeasts. Dairy products are less susceptible to mold's contamination than products such as fruits and vegetables, due to their refrigerated storage; their elaboration from heat-treated milk and, for fermented ones, the dominant microbiota that acidifies the medium. However, even cheeses and yogurts may be susceptible to mold contamination. Atypical cases of yogurt samples containing spoilage microorganisms not previously reported (molds producing gas and bacteria of the genus Gluconobacter) in Argentinean fermented milks are presented here. For yogurt, in particular, the “classic” altering organisms were always being yeasts, and in other countries, molds belonging to the genus Aspergillus. Fil: Capra, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Frisón, Laura Noemí. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina Fil: Chiericatti, Carolina Andrea Antonia. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina Fil: Binetti, Ana Griselda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Reinheimer, Jorge Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina

En la elaboración de cerveza las levaduras cumplen un rol fundamental. Además de ser responsables de llevar a cabo la fermentación, generando principalmente etanol y dióxido de carbono, también son capaces de metabolizar y producir numerosos compuestos orgánicos que tienen un impacto determinante en el aroma y el sabor final de la cerveza. Las especies Saccharomyces cerevisiae y Saccharomyces pastorianus son utilizadas tradicionalmente para la producción de cervezas ale y lager, respectivamente. No obstante, el continuo crecimiento en el mercado de la cerveza artesanal y el aumento del interés y las exigencias de los consumidores han orientado los esfuerzos hacia la producción de cervezas diferenciales e innovadoras. En este punto, las levaduras no convencionales han cobrado gran protagonismo como herramientas para el desarrollo de nuevos productos. En el presente trabajo se describe y desarrolla la potencial aplicación en el sector cervecero de diferentes especies de levaduras no convencionales pertenecientes a los géneros Brettanomyces, Torulaspora, Lachancea, Wickerhamomyces, Pichia y Mrakia, entre otras, así como también levaduras del género Saccharomyces distintas a las levaduras cerveceras tradicionales. Se detallan las condiciones de fermentación de este tipo de levaduras y su capacidad de asimilar y metabolizar diferentes componentes del mosto y de aportar características particulares al producto final. Este trabajo provee el estado del arte sobre levaduras no convencionales, lo que resulta de gran relevancia para evaluar su aplicación en la producción de cervezas artesanales con características sensoriales diferenciales, cervezas bajas en calorías, cervezas sin alcohol y cervezas funcionales. Yeasts play a crucial role in brewing. During fermentation, besides ethanol and carbon dioxide, yeasts produce a considerable number of organic compounds, which are essential for beer flavor. In particular, Saccharomyces cerevisiae and Saccharomyces pastorianus are traditionally used in the production of ale and lager beers, respectively. Nowadays, the continuous growth of the craft beer market motivates the production of differential and innovative beers; leading specialists and brewers focus on non-conventional yeasts as tools for new product development. In this work, we describe the potential application of non-conventional yeast species such as those of the genera Brettanomyces, Torulaspora, Lachancea, Wickerhamomyces, Pichia and Mrakia in the craft brewing industry, as well as non-traditional brewing yeasts of the Saccharomyces genus. Furthermore, the fermentation conditions of these non-conventional yeasts are discussed, along with their abilities to assimilate and metabolize diverse wort components providing differential characteristics to the final product. In summary, we present a comprehensive review of the state-of-the-art of non-conventional yeasts, which is highly relevant for their application in the production of novel craft beers including flavored beers, non-alcoholic beers, low-calorie beers and functional beers. Fil: Burini, Julieta Amalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina Fil: Eizaguirre, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Loviso, Claudia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; Argentina Fil: Libkind Frati, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales. Universidad Nacional del Comahue. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales; Argentina

Purpose: To evaluate atrazine behavior in an agricultural soil (adsorption–desorption, leaching) and the effects of bioaugmentation with the Arthrobacter sp. strain AAC22, as a soil remediating strategy. Material and methods: An agricultural soil with a history of atrazine application was used. Equilibrium batch experiments allowed the investigation of the adsorption–desorption of atrazine at different soil depths, while the atrazine leaching potential was assessed using disturbed soil columns. Arthrobacter sp. strain AAC22 was selected for bioaugmentation, to remove atrazine in soil microcosms. Removal efficiency was determined by a bioassay with oat seeds. Results and discussion: Adsorption and desorption isotherms of atrazine at different soil depths were well described by the Freundlich equation (R2 > 0.99 and R2 > 0.98, respectively). The Freundlich constant (Kf) and desorption coefficient (Kfd1–3) decreased and increased, respectively, as soil depth increased. The Kf and Kfd1–3 values were correlated positively to organic carbon (r = 0.97) and negatively to pH (r = − 0.93). In this soil, 70.2% of atrazine applied (2.5 kg ha−1) was recovered in the leachate and 7.6% remained in the soil column. The higher atrazine concentration leached can be explained by the negative hysteresis of adsorption–desorption in this soil. Bioaugmentation with AAC22 enhanced atrazine removal being nearly 70% after 2 days of treatment, and it was almost complete (> 99%) after 8 days. A bioassay demonstrated that bioaugmentation was successful and toxic by-products were not detected. Conclusion: The adsorption–desorption and leaching experiments demonstrated the high mobility of the atrazine in the study soil. The bioaugmentation using the AAC22 strain is an effective strategy for atrazine removal in polluted soils. Fil: Urseler, Noelia Luján. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica. - Universidad Nacional de Villa Maria. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica.; Argentina Fil: Bachetti, Romina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica. - Universidad Nacional de Villa Maria. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica.; Argentina Fil: Morgante, Verónica. Universidad Tecnologica Metropolitana (utem); . Universidad Bernardo O’Higgins; Chile Fil: Agostini, Elizabeth. Universidad Nacional de Rio Cuarto. Facultad de Cs.exactas Fisicoquimicas y Naturales. Instituto de Biotecnologia Ambiental y Salud. - Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Biotecnologia Ambiental y Salud.; Argentina Fil: Morgante, Carolina. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica. - Universidad Nacional de Villa Maria. Instituto Multidisciplinario de Investigacion y Transferencia Agroalimentaria y Biotecnologica.; Argentina

Se desarrollaron sólidos nanoestructurados impregnados con diferentes contenidos de hierro (1; 2,5; 5 y 10% p/p) como catalizadores eficaces para degradar soluciones acuosas de glifosato en condiciones de reacción extremadamente suaves: presión atmosférica y temperatura ambien-te. Estos materiales se caracterizaron por XRD, fisisorción de N2, UVvis-DR y XPS. Se obtuvieron estructuras mesoporosas regulares típicas de los sólidos SBA-15 y se pudo ajustar la especiación de Fe variando la carga nominal del metal. Los catalizadores fueron evaluados en la reacción de degradación-fragmentación de glifosato mediante oxidación húmeda catalítica con aire, logran-do niveles de degradación del herbicida del orden del 80%. Se propuso un camino de reacción basado en la formación de un intermediario oxo-hierro (V) altamente reactivo a partir del com-plejo Fe-glifosato. De esta manera, se presenta una interesante tecnología con menor impacto ambiental y mayor sustentabilidad para la remediación de aguas contaminadas con glifosato. Nanostructured solids doped with various iron contents (1, 2.5, 5 and 10wt.%) were developed as efficient catalysts to degrade glyphosate aqueous solutions under extremely mild reaction conditions, atmospheric pressure and room temperature. These materials were characterized by XRD, N2 physisorption, UVvis-DR and XPS. Regular mesoporous structures typical of SBA-15 solids were obtained and the Fe speciation could be tuned by adjusting the metal nominal loading. The catalysts were evaluated in the glyphosate degradation-fragmentation reaction by catalytic wet oxidation with air, achieving herbicide degradation levels of the order of 80%. A reaction way based on the formation of a highly reactive oxo-iron (V) intermediary from Fe-glyphosate complex was proposed. In this manner, an interesting technology with lower environmental impact and greater sustainability for the remediation of water polluted with glyphosate is presented. Fil: Vaschetto, Eliana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Gómez, María Candelaria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Ochoa Rodríguez, Pablo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Casuscelli, Sandra Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Elías, Verónica Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Eimer, Griselda Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina

La creciente tendencia al reemplazo parcial de los combustibles derivados del petróleo por aquellos provenientes de la revalorización de biomasa ha tomado recientemente gran importancia. Es por ello que el presente trabajo propone la obtención de ésteres levulínicos mediante una reacción catalítica de esterificación del ácido levulínico, molécula plataforma, con diferentes alcoholes. Para ello se han sintetizado materiales tipo MOFs (UiO-66-NH2), constituidos por circonio como fuente metálica y ácido aminotereftálico como agente liganteorgánico. Se presenta una alternativa de síntesis mediante agitación por vía ultrasónicaa temperatura de 60 ºC. Además se varía el tiempo de síntesis en autoclave de 24, 18,12 y 6 hs. La finalidad fue lograr una síntesis en condiciones más amigables con el medioambiente y mejorar las propiedades estructurales de los catalizadores. Estos se analizaronmediante difracción de rayos X, espectroscopía infrarroja, microscopía electrónica de barrido,espectroscopia de emisión atómica de plasma de microondas, isotermas de adsorciónde N2 y espectrometría de fotoelectrones inducidos por rayos X. El progreso de la reaccióncatalítica fue seguido por cromatografía gaseosa y espectroscopía de masas. Se optimizaronparámetros como la temperatura de reacción, la masa de catalizador y la relación molar dereactivos, buscando mejorar el rendimiento catalítico. Para todos los esteres levulínicos, elMOF que presentó la mayor actividad y selectividad al producto deseado fue el obtenido conun tiempo de síntesis de 6hs, con un rendimiento de 77,54 % a levulinato de metilo, 34,58 %a levulinato de etilo y 31,41 % a levulinato de butilo. The growing trend towards partial replacement of fuels derived from petroleum by those coming from the appreciation of biomass has recently taken on great importance. That is why the present work proposes obtaining levulinic esters by means of a catalytic reaction of esterification of levulinic acid, platform molecule, with different alcohols. For this, MOFs (UiO-66-NH2) type materials have been synthesized, consisting of zirconium as a metal source and aminoterephthalic acid as an organic binding agent. An alternative synthesis is presented by ultrasonic stirring at a temperature of 60 ºC. In addition, the synthesis time in autoclave is varied from 24, 18, 12 and 6 hours. The purpose was to achieve a synthesis in more environmentally friendly conditions and to improve the structural properties of the catalysts. These were analyzed by X-ray diffraction, infrared spectroscopy, scanning electron microscopy, microwave plasma atomic emission spectroscopy, N2 adsorption isotherms, and X-ray induced photoelectron spectrometry. The progress of the catalytic reaction was followed by chromatography gas and mass spectroscopy. Parameters such as reaction temperature, catalyst mass and molar ratio of reactants were optimized, seeking to improve catalytic performance. For all levulinic esters, the MOF that presented the highest activity and selectivity to the desired product was obtained with a synthesis time of 6 hours, with a yield of 77.54% to methyl levulinate, 34.58% to ethyl levulinate and 31.41% to butyl levulinate. Fil: Bravo Fuchineco, Daiana Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Heredia, Angélica Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Crivello, Mónica Elsie. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Tecnología Química. Universidad Tecnológica Nacional. Facultad Regional Córdoba. Centro de Investigación y Tecnología Química; Argentina Fil: Rodríguez Castellón, Enrique. Universidad de Málaga; España

El caseinomacropéptido es un grupo de péptidos glicosilados que contienen ácido siálico; a los mismos se le adjudican actividad anticariogénica. En el presente estudio se formularon a escala laboratorio tres yogures (experimentales) adicionados de ingredientes fuentes de estos péptidos: concentrado de proteínas de suero al 80% y caseinomacropéptido en diferentes niveles, los cuales se compararon con un yogur (control) conteniendo sólo leche en polvo descremada. A los 21 días se determinó la composición fisicoquímica, ácido siálico y actividad anticariogénica, esta última con un test de desmineralización in vitro empleando hidroxiapatita como modelo dental y dos buffers erosivos. Los yogures presentaron parámetros fisicoquímicos normales y niveles de ácido siálico en el rango entre 28,4 y 431,7 µg/g. La protección realizada por los yogures experimentales hacia el calcio y el fósforo de la hidroxiapatita fue significativamente mayor respecto al control; el valor del pH del buffer influyó en la protección. Caseinomacropeptide is a group of peptides attached to oligosacharide chains containg sialic acid; they have biological activities of interest such as anticariogenic activity. In the present study, three yogurt formulations were made at laboratory-scale with the addition of ingredients source of caseinomacropeptide: whey protein concentrate at 80% and a commercial CMP at different levels, which were compared with a yogurt (control) containing only skim powder milk. Physicochemical composition, syalic acid content and anticariogenic activity were determined in the yogurts at 21 days. Anticariogenic activity was measured through a demineralization test using hydroxyapatite (HA) as the tooth model and two acidic buffers. Physicochemical parameters were considered normal for this thype of products. Acid syalic levels ranged between 28,4 and 431,7µg/g. The protection exherted by yogurts towards calcium and phosphours of HA was significantly higher in all experimental yogurts than in control. The pH value of buffer influenced the protection. Fil: Perret, Sofía Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Vénica, Claudia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Perotti, Maria Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina Fil: Wolf, Irma Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Lactología Industrial. Universidad Nacional del Litoral. Facultad de Ingeniería Química. Instituto de Lactología Industrial; Argentina

Background: Self-assembled drug delivery systems are of much interest since they can be produced by simple low cost and solvent-free procedures. Pharmacosomes are supramolecular-structured nanocarriers with benefits for drug stability and targeting delivery. Amphotericin B (AmB) still remains an important agent for the treatment of invasive mold infections, e.g invasive aspergillo-sis, although the challenge for new formulations is still prevailing due to high rates of toxicity. Objective: We have previously reported the incorporation of AmB into 12-hydroxystearic acid lipid-based microtubes (MTs) for topical use, herein we report the ability of AmB-MTs to self-assemble into vesicles upon dilution. Methods: AmB-MTs with different drug concentrations (1, 3, 5 mg/ml) were prepared, and size de-termination was carried out for different dilutions. Morphology was evaluated by microscopy. In vitro cytotoxicity was evaluated in Vero cells and in vitro activity against Aspergillus fumigatus and Asper-gillus flavus was assessed. Results: AmB-MTs closed upon dilution to form vesicles ranging from 200 nm to 1µm. AmB MIC (Minimum inhibitory concentration) for both Aspergillus species was 0.0625 and 0.125 µg/ml for dis-persion and reconstituted lyophilized, respectively. Conclusion: AmB pharmacosome-like vesicles are smaller structures than MTs may thus be favoura-ble for other delivery routes. We assume that this kind of pharmacosomes-like carrier is a promising model for the obtention of new vesicular carriers based on lipid MTs. Fil: Salerno, Claudia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Cuestas, María Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Manco, Karina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lucangioli, Silvia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina

La perlita es una roca de origen volcánico utilizada en múltiples industrias. En San Antonio de los Cobres (Salta-Argentina) se sitúan canteras de extracción de perlita, donde es sometida a un proceso mecánico que genera desechos del mineral llamados “finos de perlita” (FP). Este trabajo presenta el análisis de hormigones con la incorporación de FPcomo adición mineral al contenido de cemento y como reemplazo del cemento, planteando dosificaciones con el fin de comprobar si la perlita puede ser considerada como una adición activa o simplemente modifica ciertas propiedades del hormigón. Se evaluaron en estado fresco el aspecto, la consistencia y el tiempo de fraguado y en estado endurecido la resistencia a compresión, módulo de elasticidad, absorción y velocidad de pulso ultrasónico. Los resultados obtenidos con incorporación de FP hasta el 10 por ciento de reemplazo del cemento muestran que es posible la utilización de este material como adición activa. Perlite is a volcanic rockused in multiple industries. In San Antonio de losCobres (SaltaArgentina) there are perlite extraction quarries, the rock is subjected to a mechanical process that generate ore waste called "perlite fines" (PF). This research presents the analysis of concrete with the incorporation of PF as a mineral addition to the cement content and as a cement replacement, proposing dosages in order to check whether perlite can be considered as an active addition or simply as a material that modifies certain properties of concrete. In the fresh state, appearance, consistency and setting time were evaluated, and in the hardened state, compressive strength, modulus of elasticity, absorption and ultrasonic pulse velocity were measured. The results obtained with the incorporation of PF up to 10 percent replacement of cement show that it is possible to use this material as an active addition. Fil: Artigas, Verónica Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Positieri, María Josefina. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina Fil: Quintana, Maria Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Oshiro, Angel. Universidad Tecnológica Nacional. Facultad Regional Córdoba; Argentina

Polymer flooding is one of the most extensively applied techniques for enhanced oil recovery (EOR) that relies on increasing the injected fluid viscosity by adding polymers in different concentrations. The aim is to improve the mobility ratio between the oil and the displacing fluid, reducing channeling effects and boosting sweep efficiency. In this work, a mixed-integer nonlinear optimization approach is developed in order to address production planning decisions, also assessing the convenience of polymer flooding in EOR projects on screening stages. This decision-making tool allows establishing optimal polymer injection strategies, setting fluid injection rates and polymer concentrations, selecting wells, and scheduling slug change operations over the planning horizon, with the aim of maximizing the net present value of the project. We propose a novel formulation combining transport phenomenon models, well productivity forecast, and geometric abstraction of the reservoir in order to address both technical and economic decisions with low computational effort. Results show that optimized strategies may outperform typical operations by up to 17% and can be found in shorter central processing unit times in comparison to traditional reservoir simulation approaches. The model has been used to tackle problems with up to 7 wells and can be tuned to different reservoir conditions. Fil: Presser, Demian Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Cafaro, Vanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Cafaro, Diego Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

Tracking control of specifc variables is key to achieve a proper fermentation. This paper analyzes a fed-batch bioethanol production process. For this system, a controller design based on linear algebra is proposed. Moreover, to achieve a reliable control, on-line monitoring of certain variables is needed. In this sense, for unmeasurable variables, state estimators based on Gaussian processes are designed. Cell, ethanol and glycerol concentrations are predicted with only substrates measurement. Simulation results when the controller and estimators are coupled, are shown. Furthermore, the algorithms were tested with parametric uncertainties and disturbances in the control action, and are compared, in all cases, with neural networks estimators (previous work). Bayesian estimators show a performance improvement, which is refected in a decrease of the total error. Proposed techniques give reliable monitoring and control tools, with a low computational and economic cost, and less mathematical complexity than neural network estimators. Fil: Fernández Puchol, María Cecilia. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Pantano, Maria Nadia. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Rodriguez Aguilar, Leandro Pedro Faustino. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Scaglia, Gustavo Juan Eduardo. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina

Fil: Meza, Barbara Erica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET. Nodo Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Fil: Meza, Bárbara Erica del Valle. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Fil: Beuter, Daiana Ayelen. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina. Fil: Brumovsky, Luis Alberto. Universidad Nacional de Misiones. Facultad de Ciencias Exactas, Químicas y Naturales; Argentina. Fil: Peralta, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET. Nodo Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Fil: Peralta, Juan Manuel. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Se estudió la cinética de secado y se estimaron los coeficientes efectivos de difusión de recubrimientos con contenido reducido de azúcarelaborados con un edulcorante comercial a base de stevia. Las formulaciones se elaboraron por triplicado utilizando cacao amargo, azúcar impalpable, una solución comercial con 7% p/p de glucósidos de steviol como sustitutivo del azúcar y aceite de soja. Se evaluaron diferentes porcentajes de stevia (75% y 50%) como edulcorante en reemplazo del azúcar, tomando como control la muestra con 100% de azúcar. El proceso de secado se llevó a cabo en una estufa con convección natural a 50 (± 1)°C y humedad relativa ambiente de 17 (± 2)%. La pérdida de humedad con el tiempo fue analizada aplicando el modelo matemático de capa fina logarítmico. Para la estimación de los coeficientes efectivos de difusión, se usó un modelo matemático simplificado derivado de la segunda ley de difusión de Fick. El cálculo de las humedades de equilibrio se realizó determinando las isotermas de desorción de agua a 50°C. A partir de los resultados obtenidos, se pudieron obtener satisfactoriamente parámetros de secado y coeficientes efectivos de difusión útiles para el estudio de la transferencia de materia que pueda ocurrir durante un proceso de recubrimiento. The drying kinetics and the estimation of the effective diffusion coefficients of confectionery coatings with low-sugar content were studied, made with a commercial stevia-based sweetener. Formulations were prepared in triplicate using defatted cocoa powder, icing sugar, commercial steviol glycosides solution (7% w/w) as sugar substitute, and soybean oil. Different contents of stevia (75% and 50%) were evaluated as sugar replacement, considering the formulation with 100% sugar as control sample. The drying process was carried out in an oven with natural convection at 50 (± 1)°C and relative ambient humidity of 17 (± 2)%. The loss of moisture over time was analysed by applying the logarithmic thin layer mathematical model. For the estimation of the effective diffusion coefficients, a simplified mathematical model derived from Fick’s second diffusion law was used. The calculation of equilibrium moisture contents was performed by determining the water desorption isotherms at 50°C. The obtained results indicated that drying parameters and effective diffusion coefficients could be obtained, being useful information for further studies about mass transfer that may occur during a coating process.

Spoilage yeasts generate considerable economic losses in the wine industry, and although sulphur dioxide (SO2) is traditionally used for control, its use has become controversial because of its negative effects on health. Biocontrol has emerged as a partial alternative to SO2, and most research has focused on the selection of biocontrol yeasts and/or the mechanisms involved, while little research has been directed to the environmental conditions that make biocontrol effective for application. When there are two or more interacting yeasts, the physicochemical factors that affect their antagonism are many and therefore the application of biocontrol is complex. To reduce SO2, the present study aimed to elucidate biocontrol mechanisms of two yeast interactions and to establish optimal physicochemical conditions for biocontrol of the spoilage yeast during grape must fermentation. Through the use of statistical design, it was possible to find relevant physicochemical factors and optimise them. Wickerhamomyces anomalus “BWa156” developed an active supernatant against Zygosaccharomyces rouxii “BZr6” while supernatant from Metschnikowia pulcherrima “BMp29” was ineffective. In mixed must fermentations, the first interaction (BWa156 vs. BZr6) showed fewer physicochemical factors impacting biocontrol compared to the second interaction (BMp29 vs. BZr6). However, the fewer factors of the first interaction had a stronger effect on the decline in the spoilage population. Validations showed that the optimal conditions for biocontrol with the first interaction could be predicted. Analysis of the results with BWa156 vs. BZr6 and BMp29 vs. BZr6 suggests that the first interaction is a competition that includes a killer toxin, while the second interaction involves competition for iron resources. Response surface methodology (RSM) allowed a reduction in the number of experiments and permitted to find the optimal biocontrol conditions (SO2: 0 mg mL-1; pH: 3.7; Reducing sugars: 23 °Brix) for the interaction between BWa156 and BZr6. Fil: Kuchen, Benjamín. Departamento de Ingenieria Agronomica ; Facultad de Ingenieria ; Universidad Nacional de San Juan; Argentina Fil: Vazquez, Fabio. Universidad Nacional de San Juan; Argentina Fil: Maturano, Yolanda Paola. Departamento de Ingenieria Agronomica ; Facultad de Ingenieria ; Universidad Nacional de San Juan; Argentina Fil: Scaglia, Gustavo Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Juan; Faculta de Ingeniaría; Instituto de Ingeniería Química; Argentina Fil: Pera, Licia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina Fil: Vallejo, Martha Dina. Universidad Nacional de San Juan; Argentina

Blends of fully and partial hydrogenated soybean oil, with 50/50 and 80/20 wt %, were chemically interesterified. The composition-texture relationships were investigated and established for the set of investigated materials. The raw materials, the original and interesterified blends, were analyzed in terms of their fatty acid and triacylglycerol compositions by gas chromatography. All materials were characterized by differential scanning calorimetry (DSC), polymorphic forms were characterized by X-ray diffraction (XRD), crystalline structures were characterized by polarized light microscopy (PLM), and textures were characterized by penetration testing. Interesterification caused a rearrangement of triacylglycerol species, reducing the concentration of trisaturated, triunsaturated, and diunsaturated triacylglycerols, increasing the amount of monounsaturated triacylglycerol, and resulting in a lowering of melting points as compared with the original blends. This modification in the chemical composition clearly changed the crystallization behavior, producing reductions in crystal size, alterations in crystalline polymorphism, and increases in plasticity in the blends. Interesterified materials displayed melting and textural characteristics suited for potential mineral wax substitutes. Fil: Romero, Sandra Zulema. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina. Universidad Nacional del Litoral; Argentina Fil: Collins, Sebastián Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

In healthier reformulated meat products throughout animal fat reduction or its replacement with emulsified oil, hydrocolloids have been extensively studied and used as stabilizers. Among them, vegetable and bacterial nanocellulose are available to be employed in meat products. Each one has similar but particular characteristics, as high water-binding and oil-binding capacities, crystallinity, and rheological properties, and could act as an emulsifying and stabilizing ingredient. Therefore, they must be studied and selected according to the necessities of the different reformulated matrixes to improve their characteristics. Several studies have evaluated the nanocellulose addition in meat products with different fat levels or pre-emulsified oil as emulsion stabilizer or fat-replacer. This review aims to discuss the main applications of nanocellulose types in healthier meat products. Fil: Marchetti, Lucas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina Fil: Andres, Silvina Cecilia. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; Argentina

Objective(s): The role of lipoproteins (LDL) as active molecules with preferential tumor interaction, but limited drug delivery capacity, has been previously reported. On the other hand, in a previous report, we demonstrated the high capacity of monosialogangliosides (GM1) micelles as drug transporters. Materials and Methods: In this work, GM1 was loaded with high doses of oncologic drugs such Paclitaxel or Doxorubicin and binded to LDL lipoproteins to form GM1-drug-LDLwater soluble complex. Evidence suggests that both, hydrophobic and electrostatic forces, participate in the interaction, regulated by conditions such as pH, temperature and ionic strength. Results: Results of DLS and TEM show that GM1-LDL complexes are considerably larger than the sum of their individual compounds, with a high charge of electronegative surface (-55.9 mV). In addition, the cytotoxic effect on cell cultures is greater when drugs are contained in GM1-LDL complexes than when loaded in GM1 micelles. Conclusion: The results suggest the participation of active energy-dependent mechanism in the uptake of GM1-LDL drug, probably linked to the LDL receptor by the tumor cells. However, we could not confirm that the transport through LDL receptors is the only one that participates in the cellular uptake of the micelles. Fil: Garro, Ariel Gustavo. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina Fil: Alasino, Roxana Valeria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Leonhard, Victoria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina Fil: Heredia, Valeria. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina Fil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina

Pachyrhizus ahipa is an unexploited crop known to be rich in proteins compared to other edible roots and tubers. These proteins are not prolamins, thus ahipa represents an interesting new source of ingredients for gluten-free foods. In this work, ahipa proteins (AP) were extracted and partially characterized in pursuit of their use as food ingredients. The effect of ultrasound treatment on protein extraction efficiency was evaluated. AP were characterized by their size, amino acid composition, surface hydrophobicity, intrinsic fluorescence, FTIR spectra, solubility, and thermal and emulsifying properties. AP were efficiently removed from the vegetal tissue using PBS or water, regardless of the use of ultrasound, but not easily recovered by precipitation. This protein fraction was composed of small proteins, with sizes ranging from 9 to 30 kDa, and highly polar. AP resulted particularly rich in aspartic acid (59% of the total amino acid content), for which they can be classified as Asp-rich proteins. Their elevated content of acidic groups was evidenced in the ATR-FTIR spectrum. The amide I band deconvolution as well as the low surface hydrophobicity and denaturation enthalpy indicated that these proteins are mainly unordered structures. The emulsifying properties of AP were enhanced when the concentration was increased from 0.1 to 1% (w/v) but resulted lower than those of soy protein. The high polarity, small size, and low isoelectric point make AP particularly suitable for acidic food matrices., Centro de Investigación y Desarrollo en Criotecnología de Alimentos

A versatile platform for the production of metal-oxide composites is reported in this work. A La0.25Ce0.52Nd0.17Pr0.06O2 – 3Ni composite is selected for this study. The composite is fabricated in a two-step method including mechanical milling of the metals/alloys and thermal treatment in air and H2. The mechanism of synthesis includes the structural transformation from cubic to hexagonal of the polymorphs present in the starting La0.25Ce0.52Nd0.17Pr0.06 alloy. The transformation is induced by milling. As a part of the analysis, the enthalpy of formation of the La0.25Ce0.52Nd0.17Pr0.06O2 compound is reported. The work reports a platform for the synthesis of composites. The microstructure of the composites is tunable for the use in different technological applications. Fil: Avalos, Agustín. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín. Instituto Sabato; Argentina Fil: Zelaya, Maria Eugenia. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones No Nucleares. Gerencia de Física (Centro Atómico Bariloche); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina Fil: Esquivel, Marcelo Ricardo Oscar. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Universidad Nacional del Comahue; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina

In this work, the corrosion behavior of bare nitinol (NiTi) alloy in Ringer's solution containing different concentrations of sodium bis(2-ethylhexyl) sulfosuccinate (AOT) was first studied in order to determine whether the surfactant acts as a corrosion inhibitor. Results of potentiostatic and potentiodynamic experiments allowed concluding that AOT is a pitting corrosion inhibitor for NiTi. In a second stage of this research work, NiTi was treated under potentiostatic control (2.00 V) for 1 h in 0.10 M AOT solutions of pH 8.4 and 12. Static and rotating electrodes were used. The influence exerted by this treatment on the passive behavior of the alloy was studied in Ringer's solution using different electrochemical and surface analysis techniques. The best anticorrosion performance was obtained using a rotating electrode and AOT solution of pH 8.4. The thin oxide layer grown potentiostatically consists of TiO2, while no Ni was found in the outermost layer. The presence of this oxide layer allows reducing the amount of Ni and Ti released at open circuit potential conditions and at very positive potentials where pitting corrosion of the bare alloy occurs. Fil: Saugo, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química. Instituto de Ingeniería Electroquímica y Corrosión; Argentina Fil: Flamini, Daniel Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química. Instituto de Ingeniería Electroquímica y Corrosión; Argentina Fil: Saidman, Silvana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química. Instituto de Ingeniería Electroquímica y Corrosión; Argentina

The present work has been conducted in order to introduce a novel approach for the design of mechanical devices conceived to manipulate the displacements field in linear elastic materials subjected to thermal gradients. Such an approach involves the solution of a topology optimization problem where the objective function defines the error in achieving a prescribed displacement field, and the mechanical device consists of two macroscopically distinguishable isotropic candidate materials. The material distribution is defined as a continuous function by following the solid isotropic microstructure (or material) with penalization (SIMP) method. The so-designed devices are easy to manufacture, since the design variables dictate the candidate materials distribution. Based on such an approach it is not necessary to devise further ways to simultaneously mimicking several thermal and mechanical effective properties, as required by coordinates transformation-based metamaterial design methods. Although the candidate materials are isotropic, the mechanical device behaves as a metamaterial allowing the desired manipulation of the displacements field. As an example, this topology optimization-based approach is applied to the design of an elastostatic cloaking device subjected to thermal gradients, considering also thermo-dependent mechanical properties. Fil: Álvarez Hostos, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina. Universidad Central de Venezuela; Venezuela Fil: Fachinotti, Victor Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Peralta, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina. Universidad Tecnológica Nacional; Argentina

Cartilage tissue engineering (CTE) has the general objective of restoring and improving damaged cartilage. A very interesting strategy of CTE is to combine different polymers to obtain a viscoelastic material. In the present study we have evaluated the applicability of Poly(2-hydroxyethyl methacrylate) networks semi-interpenetrated with sodium alginate for CTE. Alginate-containing hydrogels show an increase in scaffold porosity and swelling capacity, when compared with nonporous poly(2-hydroxyethyl methacrylate) scaffolds. Primary chondrocytes from young rats were cultured on the hydrogels, and an increase in chondrocyte proliferation and chondrocytic markers was observed in alginate-containing hydrogels. Chondrocytic phenotype was preserved on hydrogels containing the lowest amount of crosslinker and initiator (SEMI 3 and SEMI 4). In addition, Nitric oxide production by RAW264.7 macrophages grown on hydrogels was tested and none of the hydrogels showed high levels of this inflammatory marker after 2 days. These results indicate that our alginate-containing hydrogels could be useful for CTE., Laboratorio de Investigación en Osteopatías y Metabolismo Mineral, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas

The management of the collection of Municipal Solid Waste is a complex task for local governments since it consumes a large portion of their budgets. Thus, the use of computer-aided tools to support decision-making can contribute to improve the efficiency of the system and reduce the associated costs, especially in developing countries, which usually suffer from a shortage of resources. In the present work, a simulated annealing algorithm is proposed to address the problem of designing the routes of waste collection vehicles. The proposed algorithm is compared to a commercial solver based on a mixed-integer programming formulation and two other metaheuristic algorithms, i.e., a state-of-the-art large neighborhood search and a genetic algorithm. The evaluation is carried out on both a well-known benchmark from the literature and real instances of the Argentinean city of Bahía Blanca. The proposed algorithm was able to solve all the instances, having a performance similar to the large neighborhood procedure, while the genetic algorithm showed the worst results. The simulated annealing algorithm was also able to improve the solutions of the solver in many instances of the real dataset. Fil: Rossit, Diego Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería; Argentina Fil: Toncovich, Adrián Andrés. Universidad Nacional del Sur. Departamento de Ingeniería; Argentina Fil: Fermani, Matías. Universidad Nacional del Sur. Departamento de Ingeniería; Argentina

Digital-to-analog converters (DACs) with bandwidths larger than 70 GHz and sampling rates in excess of 170 GS/s will soon be required in ultra-high speed communication applications such as coherent optical transceivers operating at symbol rates of 140 GBd and beyond. Frequency interleaving has been proposed as a way to break the bandwidth bottleneck in such applications. Splitting the input signal into multiple frequency bands reduces the required bandwidth per interleaved DAC and therefore it enables the synthesis of greater bandwidth signals in the reconstructed output. Elaborate digital signal processing (DSP) is required to seamlessly stitch together the sub-bands and compensate the errors of the analog signal path, which would otherwise severely degrade the performance of the communication system. Adaptive DSP techniques are required to automatically compensate errors caused by process, voltage, and temperature variations in the technology (e.g., CMOS, SiGe, etc.) implementations of the data converters, and therefore ensure high manufacturing yield. These techniques must operate in background mode to avoid interfering with the normal operation of the communication system. This work introduces an adaptive background compensation scheme for frequency interleaved DACs (FI-DACs). The primary application example is a 128 GBd QAM16 coherent optical transceiver. However, the technique is applicable to other types of communication transceivers, and it can be generalized to arbitrary signals, as long as they are stationary or quasi-stationary and have a wideband continuous spectrum. The key elements of the proposed technique are a MIMO equalizer and the backpropagation algorithm. Numerical simulation results for the aforementioned application example show that the signal to noise and distortion ratio (SNDR) of the FI-DAC is boosted by more than 25 dB when the proposed compensation technique is applied in the presence of typical analog mismatches. Furthermore, the optical signal to noise ratio penalty of the optical transceiver is reduced from 6 dB to 0.1 dB. Fil: Galetto, Agustín C.. Fundación Fulgor; Argentina Fil: Reyes, Benjamín Tomás. Fundación Fulgor; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Morero, Damián Alfonso. Universidad Nacional de Córdoba; Argentina Fil: Hueda, Mario Rafael. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Estudios Avanzados en Ingeniería y Tecnología. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Estudios Avanzados en Ingeniería y Tecnología; Argentina

En este trabajo se presenta la evaluación del impacto ambiental y la resistencia a compresión deBloques de Tierra Comprimida (BTC) estabilizados con cal aérea hidratada y cemento Portland.Para esa labor, se fabricaron 12 series de bloques estabilizados con diferentes proporciones decal y cemento y se empleó la metodología del Análisis de Ciclo de Vida (ACV). Tras la realizaciónde los ensayos y las simulaciones pudo concluirse que, usando suelos y arena característicos de laciudad de Santa Fe (Argentina), estabilizados con determinados porcentajes de cemento Portland-comprendidos entre el 5 y el 10% en peso- pueden producirse BTC con niveles de resistenciasuficientes para ser utilizados en muros de carga y, de esa forma, minimizar el impacto ambientalnegativo asociado a su fabricación. Se concluye, además, que la estabilización con cal aéreano incrementa la resistencia a compresión de los BTC y aumenta, por el contrario, de manerasignificativa el impacto negativo de éstos sobre el medio ambiente. This work presents the evaluation of the environmental impact and compressive strength of Compressed Earth Blocks (CEB) stabilized with hydrated aerial lime and Portland cement. For this, 12 series of blocks stabilized with different proportions of lime and cement were manufactured and the Life Cycle Analysis (LCA) methodology was used. After conducting these assays and simulations, it could be concluded that, using earth and sand typical of the city of Santa Fe (Argentina), stabilized with certain percentages of Portland cement between 5 and 10% in weight, CEB can be produced with sufficient levels of strength for them to be used in load-bearing walls, in this way minimizing the negative environmental impact associated with their manufacturing. It is also concluded that the stabilization with aerial lime does not increase the CEB’s compressive strength and, on the contrary, significantly increases their negative impact on the environment. Fil: Cabrera, Santiago Pedro. Universidad Tecnologica Nacional. Facultad Reg.santa Fe. Departamento de Ingeniería Civil.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina Fil: Aranda Jiménez, Yolanda Guadalupe. Universidad Autónoma de Tamaulipas; México Fil: Suárez Domínguez, Edgardo Jonathan. Universidad Autónoma de Tamaulipas; México Fil: Rotondaro, Rodolfo. Universidad de Buenos Aires. Facultad de Arquitectura, Diseño y Urbanismo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

A Long Period Grating (LPG) is a structure inscribed in an optical fiber that is of great interest in the field of communications and sensors. At Centro de Investigaciones Ópticas (CIOp), an LPG manufacturing process was implemented. It is based on use of electric arcs produced with an optical fiber splicer to generate a series of physical disturbances that modify optical fiber behavior as a light transmission guide. Since transmission response of LPG is sensitive to fiber environment conditions, it can be used to detect changes in certain physical and chemical parameters. In particular, it enables the implementation of optical sensors sensitive to temperature, surrounding medium refractive index and axial deformation. Characterization of locally generated LPGs is essential for future design of sensors applicable in many engineering areas. In this article, typical LPG sensitivities to the three mentioned parameters are reported Fil: Alustiza, Diego Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina. Universidad Tecnológica Nacional. Facultad Regional La Plata. Departamento de Ciencias Básicas; Argentina Fil: Mineo, Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina Fil: Russo, Nelida Araceli. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina

El consumo de la energía en la edificación se ve incrementado por el aumento de la población urbana, la fuerte expansión de las ciudades y las actividades antropogénicas, especialmente en los países en desarrollo, siendo principalmente dependiente de las condiciones del clima urbano y de la morfología urbano-edilicia. El estudio tiene como objetivo profundizar el conocimiento de las variables forma y orientación de las manzanas urbanas ya que las mismas intervienen en el potencial solar de entornos urbanos típicos del área metropolitana de Mendoza (AMM), condicionando la posibilidad de utilizar estrategias de diseño bioclimático y limitando la posibilidad de acceso a los recursos que ofrece el clima en distintas épocas del año.Metodológicamente, se calculó la orientación del eje principal para la totalidad de las manzanas urbanas del AMM, en sistemas de información geográfica (SIG), y de su forma como proporción de lados de las unidades predominantemente rectangulares, lo que permitieron obtener resultados y desarrollar modelos estadísticos. Los resultados presentan limitaciones propias relacionadas con la orientación principalmente en áreas de crecimiento y densificación urbana que están llevando a una situación crítica tanto en lo ambiental como en lo energético. La investigación permitirá a futuro identificar e implementar propuestas de crecimiento y renovación urbana indispensables para una aproximación a la consecución de la sostenibilidad ambiental y energética del tejido urbano, definiendo lineamientos y estrategias. The energy consumption in the building is increased by the increase of the urban population, the strong expansion of cities and anthropogenic activities, especially in developing countries, being mainly dependent on the conditions of the urban climate and morphology urbanedilicia. The study aims to deepen the knowledge of the variables urban form and orientation since it intervenes in the solar potential of urban environments typical of the metropolitan area of Mendoza (AMM), conditioning the possibility of using bioclimatic design strategies and limiting the possibility of access to the resources offered by the climate at different times of the year. Methodologically, the orientation of the main axis for all the buildings constructed for the urban blocks of the AMM and its shape (as a proportion of sides of the predominantly rectangularunits) was calculated, using the geographic information systems (GIS). These informations allowed obtaining results and developing statistical models. The results present own limitations related to the orientation mainly in the areas of urban growth and densification that are leading to a critical situation both environmentally and energyly. The research will allow the future to identify and implement proposals for urban growth and renewal that are essential for an approach to the achievement of the environmental and energy sustainability of the urban fabric, defining guidelines and strategies Fil: Arboit, Mariela Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Ciencias Humanas, Sociales y Ambientales; Argentina Fil: Maglione, Dora Silvia. Universidad Nacional de la Patagonia Austral; Argentina Fil: Fontanive, Manuela. Politecnico di Torino; Italia

En este trabajo se presenta una metodología para la programación de operaciones de procesos "batch" en instalaciones multiproducto multietapa. El modelo matemático empleado es de tipo mixto-entero lineal (MILP) y utiliza una representación de ranuras de tiempo ("time slots"). El modelo se complementa con un algoritmo iterativo, basado en la resolución de una secuencia de subproblemas, que permite identificar y fijar la programación de la etapa cuello de botella en cada paso. La metodología propuesta apunta a obtener soluciones de buena calidad para problemas de escala industrial en tiempos de cómputo razonables. Fue aplicada a un caso de estudio real de la industria farmacéutica, que involucra la programación de 30 productos en una planta de 6 etapas y 17 equipos. Si bien no garantiza la optimalidad de la solución hallada, a diferencia de otros aportes de tipo heurístico provee una cota inferior rigurosa que permite medir la calidad de la solución. Fil: Zuffiaurre, Santiago. Universidad Tecnológica Nacional. Facultad Regional Santa Fe; Argentina Fil: Marchetti, Pablo Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

Desolventizing is a key process in the vegetable oil industry, aimed at removing residual hexane from solid meals resulting from the extraction stage of crushed oilseeds. Desolventizing takes place industrially in a large and complex piece of equipment called Desolventizer-Toaster, which uses large amounts of energy in the form of direct and indirect steam to strip the solvent adsorbed on the solid matrix and absorbed into the oil. Due to the signicant efect of this operation on the quality of the resulting our and the general economics of the entire oil 26 production process, a simulation tool to relate the main variables is considered highly useful for design and operation. In this work, a detailed mathematical model is proposed, which integrates three dierent sub models to represent the same number of dierent operating regimes that take place within the device. The model is implemented and solved in the R language and its results are in good agreement with available data. Fil: Coletto, Mauricio Miguel. Universidad Nacional de Rio Negro. Centro de Investigaciones y Transferencia de Rio Negro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia de Rio Negro; Argentina Fil: Bandoni, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina Fil: Blanco, Anibal Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina

Since COVID-19 pandemic, indoor air quality control has become a priority, and the development of air purification devices effective for disinfecting airborne viruses and bacteria is of outmost relevance. In this work, a photocatalytic device for the removal of airborne microorganisms is presented. It is an annular reactor filled with TiO2-coated glass rings and irradiated internally and externally by UV-A lamps. B. subtilis spores and vegetative cells have been employed as model biological pollutants. Three types of assays with aerosolized bacterial suspensions were performed to evaluate distinct purification processes: filtration, photocatalytic inactivation in the air phase, and photocatalytic inactivation over the TiO2-coated rings. The radiation distribution inside the reactor was analysed by performing Monte Carlo simulations of photon absorption in the photocatalytic bed. Complete removal of a high load of microorganisms in the air stream could be achieved in 1 h. Nevertheless, inactivation of retained bacteria in the reactor bed required longer irradiation periods: after 8 h under internal and external irradiation, the initial concentration of retained spores and vegetative cells was reduced by 68% and 99%, respectively. Efficiency parameters were also calculated to evaluate the influence of the irradiation conditions on the photocatalytic inactivation of bacteria attached at the coated rings. Fil: Zacarias, Silvia Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Manassero, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Pirola, Silvana Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Alfano, Orlando Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Satuf, María Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

The controlled synthesis of polymer nanoparticles is of great interest in the production of latexes with well defined characteristics. These products can be applied in biomedicine as carriers of biomolecules (e.g. proteins and enzymes), and in particular as latexes for immunoassays used for example in immunoagglutination test, which allow amplify the antigen–antibody reaction, being simple, quick and inexpensive diagnostic tools. The synthesis of polystyrene (PS) latex particles and of core–shell particles, with controlled size distribution, functional groups and surface charge densities is considered here. PS latexes were synthesized in the 100–1100 nm diameter range, by either emulsion or dispersion polymerization. Such latexes were then used as seeds in emulsion copolymerizations of styrene and a functional monomer (methacrylic acid or glycidyl methacrylate), thus producing particles with carboxyl or epoxy functionalities, respectively. Changes in the polymerization recipes employed under batch operation were analyzed. Latex characterization involved measurements of mean particle diameters, the polydispersity index, functional group densities and zeta potential. Finally, latexes were sensitized (by either physical adsorption or covalent coupling) with specific antigens to obtain latex–protein complexes, and one of them was tested as agglutination assay for detecting leptospirosis disease in bovine samples, as an example of the potential application of the latexes produced. Fil: Peretti, Leandro Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: González, Verónica Doris Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Clementi, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Gugliotta, Luis Marcelino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

In this article, we analyze the leaching kinetics with phosphoric acid of LiCoO2 samples from spent Li-ion batteries and commercial LiCoO2. The purpose was to study the mechanism by which the extraction reaction of cobalt and lithium is produced from the solid samples. The experimental results showed that raising the temperature and the reaction time contributed to improving both the extraction of Li and Co from the structure. The leaching rate of the metals from both samples in the phosphoric acid solution could be expressed as: ln (1 − X) = −b1 [ln (1 + b2t) − 1+b2bt2t]. The morphology of the solid revealed that the dissolution reaction of the samples develops from preferential growth of active sites, points susceptible to chemical interaction, occurring in one direction, giving rise to the start and progress of the reaction. The generation of these sites in the LCO-H3PO4 reaction system is of the "sequential type". The apparent activation energy values for the leaching of Co and Li would indicate that the surface chemical reaction is the rate-controlling step during this dissolution process. Fil: Pinna, Eliana Guadalupe. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; Argentina Fil: Drajlin Gordón, Diego Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; Argentina Fil: Toro, Norman. Universidad Católica del Norte; Chile. Universidad Politécnica de Cartagena; España. Universidad Arturo Prat; Chile Fil: Rodriguez, Mario Humberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Interdisciplinario de Ciencias Básicas. - Universidad Nacional de Cuyo. Instituto Interdisciplinario de Ciencias Básicas; Argentina

A strategy for the implementation of the output impedance in single-phase inverters connected in parallel with droop control for uninterruptible power supply applications is proposed in this study. The proposal allows the load current to be distributed in proportion to the power capacity of the inverters connected in parallel, by establishing the magnitude and phase of the output impedance at the fundamental frequency and its harmonics, when the voltage control is performed through odd harmonic repetitive controllers. This is accomplished through the design of an output impedance profile based on the transfer function of a second-order high-pass filter and a virtual impedance loop. The proposal achieves a correct operation of the droop control strategy and the proper sharing of the harmonics of the non-linear load current between the inverters connected in parallel, obtaining reduced values of individual harmonic content and harmonic distortion in the output voltage with reduced processing requirements. The validity of the proposal is verified through a 2 kVA experimental prototype, considering the requirements of the international quality standards IEC62040-3 and IEC61000-2-2, in terms of output voltage regulation, individual harmonic content, and harmonic distortion for inverters operating both in islanded-mode and in parallel. Fil: Astrada, Juan Carlos. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina Fil: de Angelo, Cristian Hernan. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina

This work studied for the first time the acid-induced aggregation and gelation of heat-treated chia protein isolates obtained by extraction at pH 10 or 12 (CPI10 and CPI12, respectively). The aggregation state of proteins was modified during acidification. The size of the aggregates was reduced for both samples when the pH decreased but below pH 4.5 further protein aggregation took place for CPI12. Gelation of CPI12 was completed after about 30 min of acidification with glucone-δ-lactone. By contrast, this period was not enough to reach a constant value in G′ for CPI10. When gelation was ensured, confocal laser scanning micrographs from those gels revealed a coarse and irregular structure with large pores (median size of diameters: 30 μm). Instead, micrographs from CPI12 cold gels showed a more regular and interconnected network, with smaller pores (median size of diameters: 9 μm). These differences are consistent with a higher elastic behaviour ((Formula presented.) = 13.6 ± 0.1 Pa). Fil: López, Débora Natalia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química y Física. Área Fisicoquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Química e Ingeniería-Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Ingrassia, Romina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química y Física. Área Fisicoquímica; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Busti, Pablo Andres. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química y Física. Área Fisicoquímica; Argentina Fil: Wagner, Jorge Ricardo. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Boeris, Valeria. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química y Física. Área Fisicoquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Química e Ingeniería-Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Spelzini, Darío. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química y Física. Área Fisicoquímica; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Química e Ingeniería-Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina

The phenomenon of phase inversion occurs in liquid-liquid dispersions foundin a variety of chemical engineering fields. From simple oil-water mixtures tocomplex polymeric systems, the operating variables that affect this physicalphenomenon are discussed in this work. The contribution on this matter by alarge number of researchers is critically assessed, outlining both coherent andconflicting results. A detailed review of the mechanisms by which phase inversiontakes place is also provided. While this subject has been studied for thepast 50 years, this multivariate nonlinear process is not yet comprehensivelyunderstood, and this review article aims to describe the conclusions so farreached to provide insight for future research. Fil: Maffi, Juan Martín. Instituto Tecnológico de Buenos Aires; Argentina Fil: Meira, Gregorio Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina

Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on edge contact. Herein, by leveraging on van der Waals coupling and energy level matching between two-dimensional Ruddlesden-Popper perovskite and graphene, we show that the plane-contacted perovskite and graphene interface presents a lower barrier than gold for charge injection. Electron tunneling across the interface occurs via a gate-tunable, direct tunneling-to-field emission mechanism with increasing bias, and photoinduced charge transfer occurs at femtosecond timescale (~50 fs). Field effect transistors fabricated on molecularly thin Ruddlesden-Popper perovskite using graphene contact exhibit electron mobilities ranging from 0.1 to 0.018 cm2V−1s−1 between 1.7 to 200 K. Scanning tunneling spectroscopy studies reveal layer-dependent tunneling barrier and domain size on few-layered Ruddlesden-Popper perovskite., Insulating molecular layers on the basal plane of 2D perovskite is a major bottleneck for charge injection that limiting device performance. Here, the authors show that plane-contacted graphene functions as a low barrier and gate-tunable contact to overcome this limitation.

Cloud Manufacturing (CMFg) is a novel production paradigm that benefits from Cloud Computing in order to develop manufacturing systems linked by the cloud. These systems, based on virtual platforms, allow direct linkage between customers and suppliers of manufacturing services, regardless of geographical distance. In this way, CMfg can expand both markets for producers, and suppliers for customers. However, these linkages imply a new challenge for production planning and decision-making process, especially in Scheduling. In this paper, a systematic literature review of articles addressing scheduling in Cloud Manufacturing environments is carried out. The review takes as its starting point a seminal study published in 2019, in which all problem features are described in detail. We pay special attention to the optimization methods and problem-solving strategies that have been suggested in CMfg scheduling. From the review carried out, we can assert that CMfg is a topic of growing interest within the scientific community. We also conclude that the methods based on bio-inspired metaheuristics are by far the most widely used (they represent more than 50% of the articles found). On the other hand, we suggest some lines for future research to further consolidate this field. In particular, we want to highlight the multi-objective approach, since due to the nature of the problem and the production paradigm, the optimization objectives involved are generally in conflict. In addition, decentralized approaches such as those based on game theory are promising lines for future research. Fil: Halty, Agustín. Universidad de la República; Uruguay Fil: Sánchez, Rodrigo. Universidad de la República; Uruguay Fil: Vázquez, Valentín. Universidad de la República; Uruguay Fil: Viana, Víctor. Universidad de la República; Uruguay Fil: Piñeyro, Pedro. Universidad de la República; Uruguay Fil: Rossit, Daniel Alejandro. Universidad Nacional del Sur. Departamento de Ingeniería; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Matemática Bahía Blanca. Universidad Nacional del Sur. Departamento de Matemática. Instituto de Matemática Bahía Blanca; Argentina

The entire route from anodic oxidation and surface characterization, including in vitro experiments and finally in vivo osseointegration assays were performed with the aim to evaluate nanotubular and crystalline annealed titanium oxides as a suitable surface for grade 2 titanium permanent implants. Polished titanium (T0) was compared with anodized surfaces obtained in acidic media with fluoride, leading to an ordered nanotubular structure of titanium oxide on the metal surface, characterized by tube diameter of 89 ± 24 nm (Tnts). Samples were thermally treated in air (TntsTT) to increase the anatase crystalline phase on nanotubes, with minor alteration of the structure. Corrosion tests were performed to evaluate the electrochemical response after 1, 14, and 28 days of immersion in simulated body fluid. Based on the in vitro results, heat-treated titanium nanotubes (TntsTT) were selected as a promissory candidate to continue with the osseointegration in vivo assays. The in vivo results showed no major improvement in the osseointegration process when compared with untreated Ti after 30 days of implantation and there also was a lower increase in the development of new osseous tissue. Fil: Gomez Sanchez, Andrea Valeria. Universidad Tecnológica Nacional; Argentina Fil: Katunar, María R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Pastore, Juan Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Científicas y Tecnológicas en Electrónica. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones Científicas y Tecnológicas en Electrónica; Argentina Fil: Tano de la Hoz, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina Fil: Ceré, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina

BACKGROUND: Red beet plants are cultivated worldwide for the consumption of their roots, generating large amounts of unexploited by-products. In particular, beet leaves (BLs) represent about 50% of the whole plant and are usually discarded as waste. This constitutes not only an economic issue, since multiple resources invested in the production will be wasted, but also an environmental problem because of the pollution associated with their disposal. However, BLs comprise an important source of functional compounds (polyphenols and betalains) that could be recovered from the raw material, representing a sustainable solution for the underutilization of this by-product. This study proposes the recovery of polyphenols and betalains using an aqueous ultrasound-assisted extraction (UAE) process at different powers (35, 50, and 100 W) that was characterized and optimized. RESULTS: UAE significantly enhanced the recovery of bioactive compounds and shortened the time required for extraction in comparison with traditional macerations (35 < 50 < 100 W). During UAE, the temperature of the systems increased as a function of the power applied, favouring the recovery of these phytochemicals. Additionally, a Box–Behnken design and response surface methodology were employed to optimize UAE conditions (90 W ultrasound power, 1:20 solid:liquid ratio, 16 min extraction time), under which the yields were 14.9 mg g−1 (polyphenols), 949.1 μg g−1 (betaxanthins), and 562.2 μg g−1 (betacyanins), consistent with the values predicted by the models. CONCLUSION: This study enabled the development of a green-solvent UAE process that constitutes an effective post-harvest by-products strategy to minimize losses and increase biomass utilization through the recovery of bioactive compounds from BLs, promoting sustainability in the agri-food chain. Fil: Nutter, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina Fil: Fernandez, María Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina Fil: Jagus, Rosa Juana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina Fil: Agüero, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina

Aspergillus: is a genus of filamentous and cosmopolitan fungi that includes important species for medical mycology, food, basic research and agro-industry areas. Aspergillus section Nigri are efficient producers of hydrolytic enzymes such as cellulases that are employed in the cellulose conversion. Hence, the search of new cellulolytic isolates and their correct identification is important for carrying out safe biotechnological processes. This study aimed to characterise the cellulolytic potential of Aspergillus sp. LBM 134, isolated from the Paranaense rainforest (Argentina) and to identify the isolate through a polyphasic approach. The fungus was identified as Aspergillus niger and its cellulolytic potential was evaluated by using Congo red technique and fluorescence plate assays for carboxymethyl cellulase, β-glucosidase and cellobiohydrolase, respectively. All three cellulase activities were positive; this bio-prospective positioned A. niger LBM 134 as a promising alternative for industries that require organisms capable of carrying out cellulosic biomass processing. Fil: Díaz, Gabriela Verónica. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina Fil: Coniglio, Romina Olga. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones; Argentina Fil: Chungara, Clara Inés. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina Fil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina. Universidad Nacional de Misiones; Argentina Fil: Villalba, Laura Lidia. Universidad Nacional de Misiones; Argentina Fil: Fonseca, Maria Isabel. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina

In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but also intra-patient variations related to daily insulin sensitivity (SI) changes. To overcome the large inter-subject variability, the model can also be personalized based on a priori patient information. The structure is amenable for linear parameter varying (LPV) controller design, and represents the dynamics from the subcutaneous insulin input to the subcutaneous glucose output. The efficacy of this model is evaluated in comparison with a previous control-orientedmodel which in turn is an improvement of previous models. Both models are compared in terms of their open- and closed-loop differences with respect to the UVA/Padova model. The proposed model outperforms previous T1DM control-oriented models, which could potentially lead to more robust and reliable controllers for glycemia regulation., Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales

Conventional manufacturing methods for oral administration forms are adapted to produce large batches of tablets of identical dosage form (same geometry, size and dosage). These methods are inflexible or not economically feasible to be adapted to the production of small, customized batches, either for special groups of patients or special geometries . In recent decades, additive manufacturing, more commonly known as 3D printing (3DP), has become a promising tool in many production processes, including the medical and pharmaceutical industry. This technology enables on demand, layer-by-layer fabrication of 3D objects of almost any shape and size based on digital designs. In this way, it is easy to manufacture individualized objects, custom made . This technology allows precise doses to be deposited, based on the initial ?ink? concentration and the physical dimensions of the formulation . Pharmaceutical industry interest in 3DP has grown continuously since the US FDA approval of a 3D-printed drug in August 2015. The potential of 3DP in the pharmaceutical field is enormous. 3DP simplifies the traditional manufacturing process by reducing the usual steps (grinding, wet granulation, dry granulation, compression, coating, etc.) and allows for the variation of the sizes and geometry of the tablets; and it also allows the combination of materials of different nature . Although this type of production cannot match the speed (it is 60-times slower) or the costs of large-scale production methods, the 3D printers? ability to produce different parts with enormous flexibility would allow the manufacture of pharmaceutical forms on demand, that is, to individualize drugs according to the needs of each patient, as well as it would allow combining different active ingredients (multidose tablets) Fil: Coggiola, Vivian Natali. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Real, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina Fil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina

In this article, we present a new approach to the detection of Loss-Of-Excitation (LOE), a typical failure of synchronous generators. Unlike most of the algorithms proposed in the literature, which only use the information available at the point of connection, we also take advantage of prior knowledge of the generator model. To track the field voltage and the other state variables, we have chosen the Constrained Unscented Kalman Filter (CUKF) as the core estimation technique, with phasor measurements as the input for this filtering algorithm. Detection of LOE is then performed by using the Faulty Modes Detection and Diagnosis (FMDD) algorithm, which combines the normal operation and a LOE-based model to decide in real-time whether an LOE has occurred or not. Results of simulations using a small two-area power system and the IEEE 39-bus system show that LOE detection times can be significantly reduced as compared to conventional and state-of-the-art approaches. Moreover, we observe that the new fault detection signal used to trip the generator can avoid short-term voltage stability problems. Fil: Marchi, Pablo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina Fil: Gill Estevez, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina Fil: Messina, Francisco Javier. Mc Gill University; Canadá Fil: Galarza, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Simulación Computacional para Aplicaciones Tecnológicas; Argentina

Mathematical models are an important tool in pharmaceutical formulationsdevelopment, to evaluate in vitro and in vivo drug release processes and to optimize the design of new systems. Dome Matrix technology allows the combination of modules with different types of drugs, doses, and releases kinetics. This work aimed to design drug release systems based on DomeMatrix technology, with different swelling and erosion properties, to obtain complex drug release profiles and analyze them with simple mathematical models. Most of the release profiles followed a sigmoid curve, with an inflection point corresponding to a change in the release rate behavior. The experimental data were fitted with a simple model recently developed, named the Dual Releasemodel, which consists in the combination of a modified Korsmayer-Peppas model from the beginning to the inflection point and the Lumped model from there until the end. This approach allowed determining relevant pharmaceutical parameters, such as the maximum release rate and the dissolution efficiency, among others. The use of the Dual Release model and the pharmaceutical parameters that characterize the different Dome Matrix modules allows optimizing the choice of the composition and the configuration during the development of a drug delivery system. Fil: Cid, Alicia Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Sonvico, Fabio. Università di Parma; Italia Fil: Bettini, Ruggero. Università di Parma; Italia Fil: Colombo, Paolo. Università di Parma; Italia Fil: Gonzo, Elio Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina Fil: Bermudez, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina

This paper aims to characterize a natural sediment from Bahía Blanca estuary (Argentina) as a new clay source and determine the catalytic capacity after its structural modification by an acid activation process. The acid treatment was performed by employing H2SO4 at different concentrations at 353 K and 60 min. The raw material and acid-activated samples were characterized by XRD, XRF, FTIR, N2 physisorption, TGA, SEM, EDX, potentiometric titration and pyridine adsorption monitored by FTIR. Moreover, the catalytic activity on lauric acid esterification with methanol was evaluated as a test reaction. From the structural characterization, it was determined that the material studied contains mainly Ca-montmorillonite, illite, albite and quartz. Likewise, the results obtained showed that the acid-treatment impacts the material characteristics, predominantly surface acidity and textural properties. Particularly, it was evidenced that the samples treated under medium acid activation conditions lead to an increase in acid site number and strength and specific surface area and consequently improve the catalytic activity. The results obtained evidenced that this low cost and widely available raw material presents an interesting mineralogical composition with a high clay mineral content. Additionally, the catalytic performance showed a good conversion in the test reaction regarding other heterogeneous catalysts. Hence, considering these results, this natural sediment merits further research on its purification and application. Fil: Reinoso, Deborath Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina Fil: Angeletti, Sabrina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Cervellini, Patricia Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Ciencias Biológicas y Biomédicas del Sur. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia. Instituto de Ciencias Biológicas y Biomédicas del Sur; Argentina Fil: Boldrini, Diego Emmanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina

Graphite oxide (GO) was used to anchor [PdCl2(TDA)2] and [RhCl(TDA)3] (TDA = NH2(CH2)12CH3) with 2wt % of metal load. Elemental analysis (EA), FTIR, XPS, XRD and atomic absorption spectroscopy (AA) were the techniques employed for characterization. FTIR and XRD revealed that both complexes were mainly immobilized on the GO surface. The partial hydrogenation of 1-heptyne was the test reaction to evaluate the catalytic behavior of these heterogenized complexes under mild conditions of temperature and pressure in a semi continuous process. The results were compared with those obtained with the Wilkinson catalyst under the same operational conditions. AA analysis revealed that there is no leaching of the complexes during the heterogeneous catalytic evaluations. [RhCl(TDA)3]/GO was the best catalyst due to electronic and steric effects as well as the influence of the support. Fil: Liprandi, Domingo Antonio. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina Fil: Cagnola, Edgardo Alberto. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina Fil: Mastalir, A.. University Of Szeged; Hungría Fil: Szabó, A.. University Of Szeged; Hungría Fil: Paredes, J.. Universidad Nacional del Litoral. Facultad de Ingeniería Química; Argentina Fil: Martínez Bovier, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentina Fil: Betti, Carolina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentina Fil: Badano, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentina Fil: Lederhos, Cecilia Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentina Fil: Quiroga, Monica Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; Argentina

The moisture absorption behavior of flax fiber-reinforced epoxy composites is deliberated to be a serious issue. This property restricts their usage as outdoor engineering structures. Therefore, this study provides an investigation of moisture in flax fibers on the performance of the flax/epoxy composite materials based on their shear responses. The ±45° aligned flax fibers exposed to different relative humidities (RH) and the vacuum infusion process was used to manufacture the composite specimens. The optimum shear strength (40.25 ± 0.75 MPa) was found for the composites manufactured with 35% RH-conditioned flax fibers, but the shear modulus was reduced consistently with increasing RH values. Although shear strength was increased because of fiber swelling with increased moisture absorption rate until 35% RH environments with good microstructures, nonetheless, strength and modulus both started to decrease after this range. A very poor microstructure has been affirmed by the SEM images of the composite samples conditioned at 90% RH environments. Fil: Moudood, Abdul. Griffith University; Australia Fil: Rahman, Anisur. Griffith University; Australia Fil: Öchsner, Andreas. University Of Applied Sciences. Hochschule Esslingen; Alemania Fil: Islam, Md Mainul. University Of Southern Queensland; Australia Fil: Ali, Mohammad Yeakub. Universiti Teknologi Brunei; Brunéi Fil: Francucci, Gaston Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina